- Laboratory and diagnostic tests with nursing implications. 8th ed. — Lead medical surveillance [algorithm] (119)
- Lead molecules from natural products : discovery and new trends — Lewin, Weinstein, and Riddell's Gastrointestinal pathology and its clinical implications. 2nd ed. (119)
- Lewin's Genes. X — Little SAS book for Enterprise Guide 4.2 (119)
- Liver and biliary tract surgery : embryological anatomy to 3D-imaging and transplant innovations — Lysosomes and lysosomal diseases (119)
- 2010Joyce LeFever Kee.
- 2009 ScienceDirectPaul Flecknell.Preparing for anaesthesia -- Anaesthesia -- Anaesthetic management -- Special techniques -- Analgesia and post-operative care -- Anaesthesia of common laboratory species : special considerations.
- 2015 ScienceDirectedited by James G. Fox, editor-in-chief, Lynn C. Anderson, Glen M. Otto, Kathleen R. Pritchett-Corning, Mark T. Whary.
- 2014 ScienceDirectedited by Kathryn Bayne, Patricia V. Turner.Laboratory Animal Welfare provides a comprehensive, up-to-date look into the new science of animal welfare within laboratory research. Animals specifically considered include rodents, cats and dogs, nonhuman primates, agricultural animals, avian animals and aquatic animals. The book examines the impact of experiment design and environment on animal welfare, as well as emergency situations and euthanasia practices. Readers will benefit from a review of regulations and policy guidelines concerning lab animal use, as well as information on assessing animal welfare. With discussions of the history and ethics of animals in research, and a debate on contemporary and international issues, this book is a go-to resource for laboratory animal welfare.
- 2014 ScienceDirectJavier Guillén.1. Same principles, some differences / Javier Guillen and Patri Vergara -- 2. Oversight of research animal welfare in the United States / John F. Bradfield, B. Taylor Bennett, and Cynthia S. Gillett -- 3. Canada's oversight of animal use in science / Gilly Griffin and Michael Baar -- 4. Laboratory animal science legislation in Latin America / Ekaterina Akimovna Botovchenco Rivera [and three others] -- 5. The European framework on research animal welfare regulations and guidelines / Javier Guillen [and three others] -- 6. Israeli legislation and regulation on the use of animals in biological and medical research / Rony Kalman [and three others] -- 7. Animal experimentation in Africa : legislation and guidelines / Amanda R. Hau [and five others] -- 8. Laws, regulations, and guidelines shaping research animal care and use in India / Syed SYH Qadri and Christian E. Newcomer -- 9. Oversight of animal research in China / Kathryn Bayne and Jianfei Wang -- 10. Laws, regulations, guidelines, and principles pertaining to laboratory animals in Far East Asia / Tsutomu Miki-Kurosawa, Jae Hak Park, and Chou-Chu Hong -- 11. Laws, regulations, guidelines, and principles pertaining to laboratory animals in Southeast Asia / Montip Gettayacamin [and eight others] -- 12. Laboratory animals regulations and recommendations for global collaborative research : Australia and New Zealand / John Schofield [and three others].
- 2007 CRCnetBASEReynolds M. Salerno, Jennifer Gaudioso.
- 2001 ScienceDirectJohn Dempster.
- 2010 Thieme eNeurosurgery[edited by] Brigitte Wildemann, Patrick Oschmann, Hansotto Reiber ; with contributions by J. Brettschneider [and others]."Up-to-date, comprehensive, and beautifully illustrated, Laboratory Diagnosis in Neurology presents all the measuring parameters and methods relevant to the analysis of cerebrospinal fluid, serum, and tissues affected by neurologic disease and syndromes. Following an introduction to basic concepts, the book guides clinicians through the methods of CSF analysis, neurochemical examinations, clinical applications of neuroimmunology, microbiology and virology, neurogenetic tests, and evaluation of biopsies. Readers will learn about the equipment and various procedures, and how to effectively differentiate similar methods. In the final section of the book, the authors provide a systematic introduction to the pathophysiology and laboratory findings for specific clinical disorders, indications for particular test methods, and criteria for diagnostic interpretation"--Provided by publisher.
- 2012 CRCnetBASEC. Andrew Matchett ... [et al.]."This book deals with the care and humane treatment of the laboratory ferret. Renowned for its inquisitive nature, the ferret is helping advance the current state of medical knowledge because its biological characteristics have allowed it to emerge as an important laboratory animal model for the study of human viral respiratory diseases such as influenza"--Provided by publisher.
- Witthaus, R. A.Also available: Print – 1886-
- 2008 Springeredited by Nenad Blau, Marinus Duran and K. Michael Gibson.
- 2015 SpringerSterling T. Bennett, Christopher M. Lehman, George M. Rodgers, editors ; with contributions by Kristi J. Smock and Robert C. Blaylock.
- 2007 SpringerSterling T. Bennett, Christopher M. Lehman, George M. Rodgers, editors ; with contributions by Catherine Thompson and Robert C. Blaylock.
- 2002 CRCnetBASEChristine Paszko, Elizabeth Turner.1. Historical Perspective -- 2. LIMS Fundamentals: Overview of Laboratory Information System Development and Project Planning -- 3. Data Management and Basic LIMS: Functional Requirements and Features -- 4. Data Management and Advanced LIMS: Functional Requirements and Features -- 5. Life Cycle of LIMS Software Development -- 6. Regulatory Requirements -- 7. Hardware and Operating System Requirements -- 8. Obtaining Laboratory Personnel Input -- 9. Critical Elements in Preparing a Request for Proposal -- 10. LIMS Evaluations -- 11. Enhancing Data Quality with LIMS -- 12. LIMS Validation -- Appendix A: Sample Request for Proposal -- Appendix B: Sample Scripted Demonstration -- Index.
- v. 1-5, 1973.editor, George J. Race.v. 1. Clinical chemistry -- v. 2. Hematology and blood banking. Medical microbiology, serology, and immunology -- v. 3. Special techniques -- v. 4. Body fluids, including urine. Cytology and cytogenetics. Laboratory management and function -- v.  Index.
- 2012 ScienceDirect[edited by] P. Michael Conn.Cell biology spans among the widest diversity of methods in the biological sciences. From physical chemistry to microscopy, cells have given up with secrets only when the questions are asked in the right way! This new volume of Methods in Cell Biology covers laboratory methods in cell biology, and includes methods that are among the most important and elucidating in the discipline, such as transfection, cell enrichment and magnetic batch separation. Covers the most important laboratory methods in cell biology Chapters written by experts in their fields.
- 2013 ScienceDirect[edited by] P. Michael Conn.Structural dynamics of nucleic acids by single-molecule FRET / Asger Christian Krüger, Lasse Lava Hildebrandt, Sofie Louise Kragh, Victoria Birkedal -- Visualizing the location and the dynamics of gene expression in living animals through bioluminescence imaging / Xiaojuan Chen -- Quality control protocol for confocal system / Anda Cornea -- Electron microscopy of bone / V. Everts, K.A. Hoeben -- Immunostaining : detection of signaling protein location in tissues, cells and subcellular compartments / Biswanath Maity, David Sheff, Rory A. Fisher -- Bimolecular fluorescence complementation (BiFC) analysis of protein-protein interaction : how to calculate signal-to-noise ratio / Yutaka Kodama, Chang-Deng Hu -- Immunohistochemical detection of neuropeptides/transmitters in mammalian brain / Lothar Jennes -- Intravital imaging of autoreactive T. cells in living animals / Naoto Kawakami, Ingo Bartholomäus, Marija Pesic, Nikolaos I. Kyratsous -- Genetically encoded click chemistry for single-molecule FRET of proteins / Swati Tyagi, Edward A. Lemke -- High-throughput methods for the detection of protein overexpression using fluorescence markers / Mads Gabrielsen, Andrew J. Roe, Karen McLuskey -- Correlative microscopy / Alexander A. Mironov, Galina V. Beznoussenko -- Stereology of the lung / Jan Philipp Schneider, Matthias Ochs -- Quantitative 3D cell-based assay performed with cellular spheroids and fluorescence microscopy / Nariman Ansari, Stefanie Müller, Ernst H.K. Stelzer, Francesco Pampaloni -- Optimizing fluorescence excitation and detection for intravital two-photon microscopy / Dan Suan, Henry R. Hampton, Michio Tomura, Osami Kanagawa, Tatyana Chtanova, Tri Giang Phan -- Two-dimensional crystallization by dialysis for structural studies of membrane proteins by the cryo-EM method electron crystallography / Matthew C. Johnson, Ingeborg Schmidt-Krey -- In situ hybridization / Chung-Jui Tsai, Scott A. Harding -- RNA imaging : tracking in real-time RNA transport in neurons using molecular beacons and confocal microscopy / Angélica Zepeda, Clorinda Arias, Fabian Flores-Jasso, Luis Vaca.
- 2013 ScienceDirectedited by Jon Lorsch.Section I. Cell protocols : basic microbiological techniques. Pouring agar plates and streaking or spreading to isolate individual colonies / Elizabeth Eyler ; Storage of bacteria and yeast / Cheryl M. Koh -- Section II. Cell protocols : cellular fractionation. Cellular fractionation : mammalian cells / Joerg von Hagen and Uwe Michelsen ; Cellular fractionation : yeast cells / Joerg von Hagen and Uwe Michelsen -- Section III. Cell protocols : Knock-outs and gene replacements. Yeast-gene replacement using PCR products / Megan Bergkessel, Christine Guthrie, and John Abelson ; Measuring RNAi knockdown using qPCR / Stuart Milstein, Michael Nguyen, Rachel Meyers, and Antonin de Fougerolles ; Recombineering : using drug cassettes to knock out genes in vivo / James A. Sawitzke, Lynn C. Thomason, Mikhail Bubunenko, Xintian Li, Nina Costantino, and Donald L. Court ; Gene knockouts, in vivo site-directed mutagenesis and other modifications using the delitto perfetto system in Saccharomyces cerevisiae / Samantha Stuckey and Francesca Storici ; Gene targeting and site-specific recombination in mouse ES cells / Konstantinos Anastassiadis, Frank Schnütgen, Harald von Melchner, and A. Francis Stewart ; Recombineering : highly efficient in vivo genetic engineering using single-strand oligos / James A. Sawitzke, Lynn C. Thomason, Mikhail Bubunenko, Xintian Li, Nina Costantino, and Donald L. Court -- Section IV. Cell protocols : microbiological media. Growth media for E. coli / Juliane C. Lessard ; Saccharomyces cerevisiae growth media / Jessica S. Dymond --Section V. Cell protocols : preparation of slides for microscopy. Immunohistochemistry on freely floating fixed tissue sections / Julia Bachman ; Preparation of slides for microscopy from frozen tissue sections / Julia Bachman ; Preparation of formalin-fixed paraffin-embedded tissue for immunohistochemistry / Kirstie Canene-Adams ; Preparation of cells for microscopy using cytospin / Cheryl M. Koh ; Preparation of cells for microscopy using chamber slides and coverslips / Cheryl M. Koh ; Preparation of cells for microscopy using 'cell blocks' / Cheryl M. Koh -- Section VI. Lipid and carbohydrate protocols. Enzymatic deglycosylation of glycoproteins / Min-Sung Kim and Dan Leahy -- Section VII. Lipid and carbohydrate protocol : making vesicles and micelles. Preparation of fatty acid or phospholipid vesicles by thin-film rehydration / Ting F. Zhu, Itay Budin, and Jack W. Szostak ; Vesicle extrusion through polycarbonate track-etched membranes using a hand-held mini-extruder / Ting F. Zhu, Itay Budin, and Jack W. Szostak ; Preparation of fatty acid micelles / Ting F. Zhu, Itay Budin, and Jack W. Szostak -- Section VIII. Other protocols. Reverse-phase HPLC analysis and purification of small molecules / Kirstie Canene-Adams ; Thin layer chromatography / Marina Santiago and Scott Strobel ; ATP and GTP hydrolysis assays (TLC) / Vaishnavi Rajagopal and Jon R. Lorsch.
- 2013 ScienceDirectedited by Jon Lorsch.Explanatory chapter: PCR primer design / Rubén Álvarez-Fernández -- How plasmid preparation kits work / Laura Koontz -- Introducing exogenous DNA into cells / Laura Koontz -- Agarose gel electrophoresis / Laura Koontz -- Analysis of DNA by southern blotting / Gary Glenn and Lefkothea-Vasiliki Andreou -- Purification of DNA oligos by denaturing polyacrylamide gel electrophoresis (PAGE) / Sara Lopez-Gomollon and Francisco Esteban Nicolas -- Molecular cloning / Juliane C. Lessard -- Rapid creation of stable mammalian cell lines for regulated expression of proteins using the Gateway® recombination cloning technology and Flp-In T-REx® lines / Jessica Spitzer, Markus Landthaler, and Thomas Tuschl -- Restrictionless cloning / Mikkel A. Algire -- Isolation of plasmid DNA from bacteria / Lefkothea-Vasiliki Andreou -- Preparation of genomic DNA from bacteria / Lefkothea-Vasiliki Andreou -- Preparation of genomic DNA from Saccharomyces cerevisiae / Jessica S. Dymond -- Isolation of genomic DNA from mammalian cells / Cheryl M. Koh -- Sanger dideoxy sequencing of DNA / Sarah E. Walker and Jon Lorsch -- Preparation of fragment libraries for next-generation sequencing on the applied biosystems SOLiD platform / Srinivasan Yegnasubramanian -- Next generation sequencing / Srinivasan Yegnasubramanian -- Generating mammalian stable cell lines by electroporation / Patti A. Longo, Jennifer M. Kavran, Min-Sung Kim, and Daniel J. Leahy -- Transient mammalian cell transfection with polyethylenimine (PEI) / Patti A. Longo, Jennifer M. Kavran, Min-Sung Kim, and Daniel J. Leahy -- Site-directed mutagenesis / Julia Bachman -- PCR-based random mutagenesis / Jessica S. Dymond -- Megaprimer method for mutagenesis of DNA / Craig W. Vander Kooi -- Troubleshooting PCR / Kirstie Canene-Adams -- Quantitative PCR / Jessica S. Dymond -- General PCR / Kirstie Canene-Adams -- Colony PCR / Megan Bergkessel and Christine Guthrie -- Chemical transformation of yeast / Megan Bergkessel and Christine Guthrie -- Transformation of E. coli via electroporation / Juliane C. Lessard -- Transformation of chemically competent E. coli / Rachel Green and Elizabeth J. Rogers.
- pt. A-D, 2014-15. ScienceDirectpt. B ScienceDirectpt. C ScienceDirectpt. D ScienceDirectedited by Jon Lorsch.
- 2013 ScienceDirectedited by Jon Lorsch.Computational prediction of RNA secondary structure -- Reverse-transcription PCR (RT-PCR) -- Northern blotting -- Explanatory chapter: nuclease protection assays -- In vitro transcription from plasmid or PCR-amplified DNA -- Measurement of in vivo synthesis rates -- Method for measuring mRNA decay rate in saccharomyces cerevisiae -- Analysis of polysomes from bacteria -- Polysome profile analysis - yeast -- Polysome analysis of mammalian cells -- Polysome analysis for determining mRNA and ribosome association in saccharomyces cerevisiae -- Oligo(dT)-primed RT-PCR isolation of polyadenylated RNA degradation intermediates -- Circularized RT-PCR (cRT-PCR): analysis of the 5' ends, 3' ends, and poly(A) tails of RNA -- RNA radiolabeling -- Fluorescently labeling synthetic RNAs -- Analysis of RNA by analytical polyacrylamide gel -- RNA purification by preparative polyacrylamide gel -- Explanatory chapter: nucleic acid concentration determination -- RNA purification-precipitation methods -- Reverse transcriptase dideoxy sequencing of RNA -- RNA structure experimental analysis-chemical modification -- Structural analysis of RNA backbone using in-line probing.
- 2001 CRCnetBASEMark A. Suckow, Peggy Danneman, Cory Brayton.
- 2012 ScienceDirectedited by Hans J. Hedrich.
- 2002 CRCnetBASEJeffey D. Fortmann, Terry A. Hewett, and B. Taylor Bennett.
- 2005 ScienceDirectedited by Sonia Wolfe-Coote.
- 2014 CRCnetBASEPrakash Singh Bisen, Emeritus Scientist, Defense Research Development Establishment, Defense Research Development Organization, Ministry of Defense, Government of India, Gwalior, India .Microscopy -- Microtome -- pH and Buffers -- Spectrophotometer -- Centrifugation -- Radiation Biology -- Chromatography -- Separation Technology -- Histochemical Techniques -- Cytogenetics -- Biomolecules -- Enzymology -- Membranes -- Photosynthesis and Respiration -- Microbiology -- Soil Biology -- Virology -- Immunochemical Methods -- Genetic Engineering -- Molecular Biology -- Biosensors -- Enzyme Immobilization -- Plant Tissue Culture -- Animal Cell Science and Technology -- Bioprocess Engineering -- Environmental Biology -- Bioinformatics
- 2013 SpringerVijai Kumar Gupta, Maria G. Tuohy, editors ; Manimaran Ayyachamy, Kevin M. Turner, Anthonia O'Donovan, associate editors.Laboratory Protocols in Fungal Biology presents the latest techniques in fungal biology. This book analyzes information derived through real experiments, and focuses on cutting edge techniques in the field. The book comprises 57 chapters contributed from internationally recognised scientists and researchers. Experts in the field have provided up-to-date protocols covering a range of frequently used methods in fungal biology. Almost all important methods available in the area of fungal biology viz. taxonomic keys in fungi; histopathological and microscopy techniques; proteomics methods; genomics methods; industrial applications and related techniques; and bioinformatics tools in fungi are covered and complied in one book. Chapters include introductions to their respective topics, list of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting. Each chapter is self-contained and written in a style that enables the reader to progress from elementary concepts to advanced research techniques. Laboratory Protocols in Fungal Biology is a valuable tool for both beginner research workers and experienced professionals.
- 2012 ScienceDirectedited by Mark A. Suckow, Karla A. Stevens, Ronald P. Wilson.The Laboratory Rabbit, Guinea Pig, Hamster, and Other Rodents is a single volume, comprehensive book sanctioned by the American College of Laboratory Animal Medicine (ACLAM), covering the rabbit, guinea pig, hamster, gerbil and other rodents often used in research. This well illustrated reference includes basic biology, anatomy, physiology, behavior, infectious and noninfectious diseases, husbandry and breeding, common experimental methods, and use of the species as a research model. With many expert contributors, this will be an extremely valuable publication for biomedical researchers, laboratory animal veternarians and other professionals engaged in laboratory animal science. A new gold standard publication from the American College of Laboratory Animal Medicine series One stop resource for advancements in the humane and responsible care of: rabbit, guinea pig, hamster, gerbil, chinchilla, deer mouse, kangaroo rat, cotton rat, sand rat, and degu Includes up-to-date, common experimental methods Organized by species for easy access during bench research.
- 2013 CRCnetBASEPatrick Sharp and Jason Villano.Important biological features -- Husbandry -- Management -- Veterinary care -- Experimental methodology.
- 2006 ScienceDirectedited by Mark A. Suckow, Steven H. Weisbroth, Craig L. Franklin.Historical foundations / J. Russell Lindsey and Henry J. Baker -- Ethical and legal perspectives / Beverly J. Gnadt -- Taxonomy and stocks and strains / Hans J. Hedrich -- Morphophysiology / John Hofstetter, Mark A. Suckow, and Debra L. Hickman -- Clinical pathology of the rat / Bruce D. Car ... [et al.] -- Reproduction and breeding / Jeffrey J. Lohmiller and Sonya P. Swing -- Assisted reproductive technologies and genetic modifications in rats / Yuksel Agca and John K. Critser -- Analysis of behavior in laboratory rats / Ian Q. Whishaw ... [et al.] -- Nutrition / Sherry M. Lewis ... [et al.] -- Housing and environment / Robert E. Faith and Jack R. Hessler -- Bacterial, mycoplasmal and mycotic infections / Steven H. Weisbroth, Dannis F. Kohn, and Ron Boot -- Viral disease / Robert O. Jacoby and Diane J. Gaertner -- Parasitic diseases / David G. Baker -- Neoplastic disease / Gary A. Boorman and Jeffrey I. Everitt -- Metabolic, traumatic, and miscellaneous diseases / William W. King and Steven P. Russell -- Medical management and diagnostic approaches / Glen Otto and Craig L. Franklin -- Occupational health and safety / Sanford H. Feldman and David N. Easton -- Experimental modeling and research methodology / Michael A. Koch -- Anesthesia and analgesia / George A. Vogler -- Euthanasia and necropsy / Jeffrey I. Everitt and Elizabeth A. Gross -- Integrating biology with rat genomic tools / Carol Moreno-Quinn and Howard J. Jacob -- Gnotobiotics / Philip b. Carter and Henry L. Foster -- Spontaneous, surgically and chemically induced models of disease / Dwight R. Owens -- The nude rat / Martha A. Hanes -- Gerontology and age-associated lesions / Nancy L. Nadon -- Cardiovascular research / Peter G. Anderson, Sanford P. Bishop, and J. Thomas Peterson -- Toxicology / Thomas E. Hamm, Mary Ann Vasbinder, and Angela King-Herbert -- Embryology and teratology / Carol Erb -- Immunology / Veronica Jennings and Dirck Dillehay -- Wild and black rats / Marc Hulin and Robert Quinn.
- 2014 ScienceDirectby Anders Kallner.Laboratory Statistics: Handbook of Formulas and Terms presents common strategies for comparing and evaluating numerical laboratory data. In particular, the text deals with the type of data and problems that laboratory scientists and students in analytical chemistry, clinical chemistry, epidemiology, and clinical research face on a daily basis. This book takes the mystery out of statistics and provides simple, hands-on instructions in the format of everyday formulas. As far as possible, spreadsheet shortcuts and functions are included, along with many simple worked examples. This book is a must-have guide to applied statistics in the lab that will result in improved experimental design and analysis. Comprehensive coverage of simple statistical concepts familiarizes the reader with formatted statistical expressionSimple, worked examples make formulas easy to use in real lifeSpreadsheet functions demonstrate how to find immediate solutions to common problemsIn-depth indexing and frequent use of synonyms facilitate the quick location of appropriate procedures.
- 2013 ClinicalKeyedited and authored by Cynthia C. Chernecky, Barbara J. Berger."Look no further for quick, complete answers to questions such as which laboratory tests to order or what the results might mean. Laboratory Tests And Diagnostic Procedures, 5th Edition covers more tests than any other reference of its kind, with over 900 lab tests and diagnostic procedures in all. In Part I, you'll find a unique, alphabetical list of hundreds of diseases, conditions, and symptoms, including the tests and procedures most commonly used to confirm or rule out a suspected diagnosis. Part II presents key information on virtually every laboratory and diagnostic test available. All test entries are up-to-date, concise, complete, and consistently presented, making this resource the perfect choice for students or practitioners who need fast, accurate information on diagnostic tests."--Publisher's website.
- 2010Sherril L. Green."Even though Xenopus is one of the two most popular non-mammalian animals used in biomedical research, their value in the lab suffers from a lack of standardization regarding their optimal care, breeding, and housing." "Filling the need for such a reference, The Laboratory Xenopus sp. provides researchers and lab managers with a practical, step-by-step manual that emphasizes the humane care and use of captive clawed frogs in basic as well as biomedical, and toxicological research." "Supported with hypothesis-driven research, this well-organized manual explores the full range of responsibilities facing individuals who work with this species. The content is divided into intentionally brief sections that allow for the quick retrieval of essential information regarding important biological features and experimental methodology, as well as compliance and veterinary care, husbandry, housing, and water quality management."--BOOK JACKET.
- 2001 CRCnetBASERick Bitter, Taqi Mohiuddin, Matt Nawrocki.
- 2006 Springeredited by Adam J. Cohen, Michael Mercandetti, Brian G. Brazzo.Anatomy of the lacrimal system -- Gender and racial variations of the lacrimal system -- Nasal anatomy and evaluation -- Congenital etiologies of lacrimal system obstructions -- Acquired etiologies of lacrimal system obstructions -- Evaluation of the tearing patient -- Imaging and clinical evaluation of the lacrimal drainage system -- The tear-deficient patient -- Surgery of the punctum and canaliculus -- Lacrimal trauma -- Primary external dacryocystorhinostomy -- Primary endonasal dacryocystorhinostomy -- Transcanalicular dacryocystorhinostomy -- Conjunctivodacryocystorhinostomy -- Endoscopic conjunctivodacryocystorhinostomy -- Pediatric balloon catheter dacryocystoplasty -- Balloon-assisted dacryoplasty in adults -- Balloon-assisted lacrimal surgery -- Nine-millimeter endoscopic balloon dacryocystorhinostomy: a new, less-invasive procedure for tearing in adults -- Radiofrequency dacryocystorhinostomy -- Powered endoscopic dacryocystorhinostomy -- Laser dacryocystorhinostomy: part 1. laser-assisted endonasal endoscopic dacryocystorhinostomy -- Laser dacryocystorhinostomy: part 2. laser-assisted endonasal endoscopic dacryocystorhinostomy with the holmium:YAG laser -- Laser dacryocystorhinostomy: part 3. laser-assisted endonasal endoscopic dacryocystorhinostomy with the potassium titanyl phosphate laser -- Revision dacryocystorhinostomy -- The adjunctive use of mitomycin C in dacryocystorhinostomy -- The Griffiths nasolacrimal catheter -- The Sisler lacrimal canalicular trephine.
- 2015 Springeredited by Adam J. Cohen, Michael Mercandetti, Brian Brazzo.While there are books that review lacrimal system disorders and surgery as a section of comprehensive oculoplastic textbooks, The Lacrimal System: Diagnosis, Management and Surgery solely addresses Lacrimology in one concise, practical volume. Building off of the success of the first edition, this text includes significantly updated information, new authors from around the world as well as new chapters that are complete with high quality images and illustrations. Lacrimal surgeries are commonly performed by oculoplastic surgeons and range from alleviating lacrimal system obstructions in children with congenital dysmorphology to minimally invasive lacrimal system reconstruction. The second edition of this book meets the needs of practicing physicians, fellows, and residents who are managing the tearing patient clinically and surgically.
- v. 1-4, 1974-78.edited by Bruce L. Larson and Vearl R. Smith.v. 1. The mammary gland: development and maintenance -- v. 2. Biosynthesis and secretion of milk. Diseases -- v. 3. Nutrition and biochemistry of milk. Maintenance.
- 2012 CRCnetBASE[edited by] Sampo Lahtinen, Arthur C. Ouwehand, Seppo Salminen, Atte von Wright."Updated with the substantial progress made in lactic acid and bacteria research since the third edition, this fourth volume discusses improved insights in genetics and new molecular biological techniques. Thoroughly reorganized, this book incorporates the recent changes in new molecular techniques and the mechanistic understanding of probiotic functionality. The book remains firmly grounded in the basics of lactic acid bacteria; their genetics and taxonomy, their application in food and feed preparation, their health properties, and the legal issues associated with their use"--Provided by publisher.
- 2012 SpringerYoshiharu Takayama."Lactoferrin was first identified as an iron-binding glycoprotein abundantly found in milk. It has been considered to play important roles in host defense, since lactoferrin shows broad spectrum of anti-bacterial and anti-viral activities, arising from its iron-chelating property. Furthermore, lactoferrin can regulate the function of innate and adaptive immune cells and exhibits immuno-modulating properties. These activities of lactoferrin implicate that potential use of lactoferrin as a wound healing agent. In addition, this book shows that lactoferrin is a potent regulator of dermal fibroblasts and epidermal keratinocytes, and promotes skin or corneal epithelial wound healing by increasing their proliferation, migration or deposition of extracellular matrix (ECM) components such as collagen and hyaluronan. This book provides the scientific background on use of lactoferrin as a wound healing agent. Indeed, lactoferrin exerts its biological effects by binding to specific lactoferrin receptors on target cells. This book also covers the in-depth information on roles of lactoferrin as a signaling molecule."--Publisher's website.
- 2010Jared Starman.Cone-beam computed tomography (CBCT), which uses much of the same hardware as traditional 2-D x-ray fluoroscopy, is now being used during patient treatment. The ability to perform CBCT scans has been driven by the development of amorphous silicon (a-Si) digital flat-panel (FP) x-ray detector technology. These detectors were originally designed for radiography and fluoroscopy, but because of their compactness, flexibility, low spatial distortion, and relative low-cost, are also practical for CBCT. One factor limiting the CBCT image quality for a-Si x-ray detectors is detector lag, stemming from charge trapping in the a-Si layer. Lag is defined as residual signal present in the detector, and can lead to a range of image artifacts in CBCT reconstructions, such as severe image shading for elliptical or off-center objects that could potentially obscure anatomy of interest. Current lag correction methods for a-Si FP detectors assume that the detector is linear and time invariant (LTI) and determine a temporal impulse response for the system. The detector output is deconvolved with the measured impulse response to compute the lag-corrected data. However a conventional FP is neither linear nor time invariant. Different techniques for measuring the FP impulse response are examined, as well as their effect on the final CBCT image reconstruction. A range of results are achieved by the different techniques, highlighting the non-linearity and time variance of the system. A novel non-LTI algorithm is then presented that better describes the x-ray detector dynamics, gives exposure independent results, and provides significant error reduction in CBCT for large objects where lag artifacts are most severe. A second method to reduce lag based on a hardware change to the a-Si detector is also described in this dissertation. The photodiode at each detector pixel is briefly operated in a forward bias mode to maintain saturation of charge trap states. Detector measurements and CBCT scans with and without the detector forward biasing are made to show image improvement and the trade-offs of using the hardware method.
- 2006by Kenneth F. Schulz, David A. Grimes ; foreword by Richard Horton.
- 2006edited by Richard M. Rocco.
- 2010edited by Reuben D. Johnson, Alexander L. Green.Neurovascular neurosurgery / A.L. Green, R.D. Johnson, R.S.C. Kerr -- Neuro-oncology / R.D. Johnson, K.J. Drummond, K.J.O.L. Khu, M. Bernstein -- Head injury / R.D. Johnson, T. Santarius, J.E. Wilberger -- Spinal surgery / R.D. Johnson, J.C.D. Leach, W.A. Liebenberg, N. Maartens, S.A. Cudlip -- Functional and epilepsy neurosurgery / A.L. Green, R.D. Johnson, A. Astradsson, R.J. Stacey, T.Z. Aziz -- Paediatric neurosurgery / R.D. Johnson, P. Richards, J. Jayamohan, S. Sinha.
- 2009Shantanu Banik, Rangaraj M. Rangayyan, Graham S. Boag.
- 2006[edited by] Joel S. Goldberg.
- 2006[edited by] Joel S. Goldberg.
- 2006[edited by] Joel S. Goldberg.Review of hundreds of commonly tested diseases. Covers diseases and syndromes likely to be tested on the USMLE step 2 exam.
- 2006Joel S. Goldberg.
- 2007Yashesh Patel, Barry J. Goldlist.Cardiology -- Skin -- Endocrinology -- Gastroenterology -- Hematology -- Oncology -- Diseases of the nervous system -- Kidneys -- Muscles and joints -- Infection -- Immunology and allergy -- Diseases of the respiratory system -- Clinical pharmacology -- Comprehensive review.
- 2007 AccessSurgery, Users must register and sign in to take a test[edited by] C. Gene Cayten, Nanakram Agarwal, Max Goldberg, Simon Wapnick.Surgical critical care/pre and post operative care / Nanakram Agarwal and Akella Chendrasekhar -- Skin, soft tissue, and breast / Aloysius Smith and Andrew Ashikari -- Endocrine, head, and neck / Alan S. Berkower and Prakashchandra Rao -- Cardiac and thoracic / Marshall D. Kramer and E.A. Bonfils-Roberts -- Stomach, duodenum, and esophagus / Soula Priovolos and Max Goldberg -- Small and large intestins and appendix / Evelyn Irizarry and Nicholas A. Balsano -- Pancreas, biliary tract, liver, and spleen / Valerie L. Katz and Akella Chendrasekhar -- Hernia / Max Goldberg and Nanakram Agarwal -- Male and female genitourinary systems / Sean Fullerton and David Samadi -- Vascular / Nilesh N. Balar and Mayank V. Patel -- Neurosurgery / Kamran Tabaddor -- Trauma / C. Gene Cayten and Rao R. Ivatury -- Pediatric surgery / Tyr Ohling Wilbanks and Meno Lueders -- Practice test / James E. Barone and C. Gene Cayten.Also available: Print – 2007
- 2008[edited by] Carlyle H. Chan.Internal medicine / Ann M. Mcguire and Michael Bonner -- Obstetrics and gynecology / E. James Aiman and Michael R. Lund -- Pediatrics / Rainer G. Gedeit -- Preventive medicine / Stephen K. Liu -- Psychiatry / Jon A. Lehrmann -- Surgery / Kelli Brown and Travis Webb -- Practice test block 1 -- Practice test block 2 -- Practice test block 3 -- Practice test block 4 -- Practice test block 5 -- Practice test block 6 -- Practice test block 7 -- Practice test block 8.
- 2006Louis A. Vontver ... [et al.].
- Access to 3000+ exam questions.
- Langman's Medical embryology : T.W. Sadler ; original illustrations by Jill Leland ; computer illustrations by Susan L. Sadler-Redmond ; scanning electron micrographs by Kathy Tosney and Jennifer Burgoon ; ultrasound images by Nancy Cheschier and Hytham Imseis.. 10th ed.2006Sadler, T. W.; Langman, Jan.Embryology : old and new frontiers and an introduction to molecular regulation and signaling -- Gametogenesis : conversion of germ cells into male and female gametes -- First week of development : ovulation to implantation -- Second week of development : bilaminar germ disc -- Third week of development : trilaminar germ disc -- Third to eighth weeks : the embryonic period -- Third month to birth : the fetus and placenta -- Birth defects and prenatal diagnosis -- Skeletal system -- Muscular system -- Body cavities -- Cardiovascular system -- Respiratory system -- Digestive system -- Urogenital system -- Head and neck -- Central nervous system -- Ear -- Eye -- Integumentary system.
- 2010T.W. Sadler ; original illustrations by Jill Leland ; computer illustrations by Susan L. Sadler-Redmond ; scanning electron micrographs by Kathy Tosney ; ultrasound images by Nancy Chescheir and Hytham Imseis.Embryology : old and new frontiers and an introduction to molecular regulation and signaling -- Gametogenesis : conversion of germ cells into male and female gametes -- First week of development : ovulation to implantation -- Second week of development : bilaminar germ disc -- Third week of development : trilaminar germ disc -- Third to eighth weeks : the embryonic period -- Third month to birth : the fetus and placenta -- Birth defects and prenatal diagnosis -- Skeletal system -- -- Muscular system -- Body cavities -- Cardiovascular system -- Respiratory system -- Digestive system -- Urogenital system -- Head and neck -- Central nervous system -- Ear -- Eye -- Integumentary system.
- 2013edited by Michael A. Arbib."This book explores the relationships between language, music, and the brain by pursuing four key themes and the crosstalk among them: song and dance as a bridge between music and language; multiple levels of structure from brain to behavior to culture; the semantics of internal and external worlds and the role of emotion; and the evolution and development of language. The book offers specially commissioned expositions of current research accessible both to experts across disciplines and to non-experts. These chapters provide the background for reports by groups of specialists that chart current controversies and future directions of research on each theme." -- [Publisher-supplied data]
- 2011 SpringerJens-Uwe Stolzenburg, Ingolf A. Türk, Evangelos N. Liatsikos (editors).Upper Urinary Tract (Kidney, Ureter and Adrenal Gland) / Jens-Uwe Stolzenburg, Rowan Casey, Jens Mondry, Minh Do and Anja Dietel, et al. -- Lympadenectomy / Ingolf A. Türk, Rowan Casey, Jens-Uwe Stolzenburg, Panagiotis Kallidonis and Minh Do, et al. -- Urinary Bladder and Prostate / Thilo Schwalenberg, Jochen Neuhaus, Panagiotis Kallidonis, Evangelos N. Liatsikos and Jens-Uwe Stolzenburg, et al. -- Paediatric Urology / Holger Till, Jens-Uwe Stolzenburg and Ulrike Waldschmidt -- Miscellaneous / Jens-Uwe Stolzenburg, Evangelos N. Liatsikos, Thilo Schwalenberg, Tim Häfner and Minh Do, et al.
- 2014 SpringerFerdinando Agresta, Fabio Cesare Campanile, Nereo Vettoretto, editors."his book, written by expert surgeons, offers a comprehensive and up-to-date overview of all aspects of laparoscopic cholecystectomy. Coverage includes the indications for surgery, anesthesia, establishment of pneumoperitoneum, surgical technique, and the prevention and management of complications. Performance of laparoscopic cholecystectomy in the specific contexts of biliary tree stones and acute cholecystitis is described. Extensive reference is made to the latest clinical evidence, and the real benefits of the laparoscopic approach, for example in terms of outcomes and day surgery, are carefully assessed. New technologies, including SILS, NOTES, robotic surgery, and miniaturized instruments, are reviewed. The learning curve and training are also extensively discussed, and an individual chapter is devoted to the views of international experts in the field. Some 20 years after the National Institutes of Health Consensus Conference first published recommendations regarding indications for laparoscopic cholecystectomy, it remains the gold standard approach and continues to evolve."--Publisher's website.
- 2006 SpringerJeffrey W. Milsom, Bartholomäus Böhm, Kiyokazu Nakajima.Also available: Print – 2006
- 2012 SpringerAndrea Tinelli, editor.Anatomy of the abdominal wall and vaginal entry in relation to complications of access and injury in laparoscopy / Tom A.J. Schneider -- Surgical technique of traditional laparoscopic access / Gernot Hudelist and Jorg Keckstein -- Laparoscopic abdominal entry by the ternamian threaded visual system / Artin Ternamian -- Initial access to the peritoneal cavity for laparoscopic surgery in obese patients / Charlotte Rabl and Guilherme M. Campos -- The direct optical access: a feasible, reliable, and safe laparoscopic entry / Andrea Tinelli -- Robotic assisted surgery and related abdominal entry / Crisitina Falavolti, Roberto Angioli, Patrizio Damiani, and Maurizio Buscarini -- Robotic assisted surgery entry into gynecological oncology / Farr R. Nezhat and Shao-Chun R. Chang-Jackson -- Single access surgery: less is more? / Tahar Benhidjeb, Michael Stark, Jakob R. Izbicki, and Oliver Mann -- Reduced port surgery: single port access to the abdominal and pelvic cavity / Paul G. Curcillo II, Stephanie A. King, and Erica R. Podolsky -- The evolution of minimally invasive gynecological surgery: gas-less laparoscopic inspection and single hole surgery (GLISHS) / Nicola Gasbarro, Maurizio Brusati, Pietro Lupo, Sandro Gerli, and Gian Carlo Di Renzo -- First abdominal access in gynecological laparoscopy: comparison of techniques / Antonio Malvasi and Andrea Tinelli -- Blind entry at gynecological laparoscopy is substituted by entry under sight: complications in conventional laparoscopic entry / Liselotte Mettler, Wael Sammur, and Antonio Malvasi -- Natural orifice surgery: surgical procedures through natural body openings / Michael Stark and Tahar Benhidjeb -- Access in natural orifice transvaginal endoscopic surgery / Daniel A. Tsin.
- 2015 SpringerChang-Ming Huang, Chao-Hui Zheng, editors.
- 2011 Springerauthor, Karl Miller ; assisted by Birgit Wahl ... [et al.].
- 2015 SpringerXiujun Cai.Anatomy of the Liver in the Laparoscopic Situation -- Instruments for Laparoscopic Hepatectomy by Curettage and Aspiration -- Laparoscopic Left Lateral Segmentectomy -- Laparoscopic Left Hemihepatectomy -- Laparoscopic Right Hemihepatectomy -- Laparoscopic Resection of Caudate Lobe -- Laparoscopic Non-Anatomical Liver Resection -- Two-Stage Completely Laparoscopic Hemihepatectomy -- Laparoscopic Radical Resection of Gallbladder Cancer -- Other Techniques for Laparoscopic Hepatectomy.
- 2016 SpringerGiusto Pignata, Umberto Bracale, Fabrizio Lazzara, editors.Esophagus and Stomach -- Liver, Gallbladder, and Biliary Tree -- Abdominal Wall -- Colon, Rectum, and Appendix -- Kidney, Adrenal Gland, Ureter, and Varicocele -- Spleen and Pancreas -- Bariatic Surgery -- Gynecology.
- 2009 Springerby Bertrand Guillonneau, Inderbir S. Gill, Günter Janetschek, Ingolf A. Tuerk.
- 2005 SpringerJean J.M.C.H. de la Rosette, Inderbir S. Gill, editors.
- 2013 SpringerFelix Schier, Salmai Turial.When Laparoscopy in Children was first published in 2003, it quickly became popular with pediatric surgeons worldwide owing to its clear schematic drawings and concise text. This new edition has been revised and enlarged to cover the new procedures and other advances that have emerged in the intervening period, during which the number of operations has almost doubled. Now, the vast majority of indications for laparoscopy in children are presented and discussed. Each operation is systematically described and illustrated step by step, providing the reader with the technical guidelines required to perform laparoscopy safely even in small children. Laparoscopy in Children will be an invaluable guide for all surgeons who perform, or plan to perform, such operations.
- 2014 CRCnetBASEeditors, Sherif Sakr, Mohamed Medhat Gaber."This book provides a central source of reference on the various data management techniques of large scale data processing and its technology application. This book presents chapters written by leading researchers, academics, and practitioners in the field, all of which have been reviewed by independent reviewers. The book covers the latest research discoveries and applications. Coverage includes cloud data management architectures, big data analytics visualization, data management, analytics for vast amounts of unstructured data, clustering, classification, link analysis of big data, scalable data mining, and machine learning techniques"-- Provided by publisher.
- 2006Cyrus Abraham Wilson.
- 2003 NAPSharyl J. Nass and Bruce W. Stillman, editors ; Committee on Large-scale Science and Cancer Research, National Cancer Policy Board and Division on Earth and Life Studies, National Research Council.Also available: Print – 2003
- 2012Yann Chong Tan.Despite tremendous progress in understanding immune responses, the ability to characterize functional antibody responses remains limited. I developed a method that utilizes barcoding to enable high-throughput sequencing of paired heavy-chain and light-chain immunoglobulin sequences. This approach enables us to generate dendrograms of functional affinity-matured antibody responses, and express selected antibodies for functional characterization. This method was applied to a human who received an influenza vaccine, humans with Staphylocuccus aureus infection, a human with rhuematoid arthritis, an autoimmune disease, and a human who has lung adenocarcinoma, and is a long term non-progressor. These are examples in vaccination, infection, autoimmune disease and cancer, respectively. In each case, we show that we were able to obtain paired heavy and light chain sequences. We expressed selected antibodies for functional characterization and showed that we were able to obtain functional antibodies that bound to target antigens in each of the above indications. Furthermore, we also showed that large clonal families dominate in influenza vaccination, and that larger antibody clonal families have higher binding affinities. Taken together, the approach provides a method to directly characterize functional antibody responses that could advance our understanding of protective and pathogenic immune responses in health and disease.
- 2011 SpringerZvi Laron, John J. Kopchick, editors.Laron syndrome (LS), or primary growth hormone (GH) insensitivity, was first described in 1966. Since then, many patients worldwide have been diagnosed with LS, which involves defects in the GH receptor that cause combined congenital deficiency of GH and IGF-I activities. In this comprehensive book the authors draw upon 50 years of multidisciplinary clinical and investigative follow-up of the large Israeli cohort of LS patients. The genetic basis of the syndrome is fully considered, and all aspects of the pathophysiology of IGF-I deficiency are described. Data derived from the recently generated mouse model of LS are reviewed and compared with the human LS experience. Valuable advice is provided on treatment, and treatment effects, such as metabolic effects, adipose tissue alterations, and impact on aging, are fully explored. Together, this book condenses, consolidates, compares, and contrasts data derived from the human and mouse LS experiences and provides a unique resource for clinical and basic scientists to evaluate and compare IGF-I and GH actions.
- 2015 ClinicalKeyGary C. Schoenwolf, Steven B. Bleyl, Philip R. Brauer, Philippa H. Francis-West.Gametogenesis, fertilization, and first week -- Second week : becoming bilaminar and fully implanting -- Third week : becoming trilaminar and establishing body axes -- Fourth week : forming the embryo -- Principles and mechanisms of morphogenesis and dysmorphogenesis -- Fetal development and the fetus as patient -- Development of the skin and Its derivatives -- Development of the musculoskeletal system -- Development of the central nervous system -- Development of the respiratory system and body cavities -- Development of the heart -- Development of the vasculature -- Development of the gastrointestinal tract -- Development of the urinary system -- Development of the pharyngeal apparatus and face -- Development of the ears -- Development of the eyes -- Development of the limbs.
- 2009Gary C. Schoenwolf, Steven B. Bleyl, Philip R. Brauer, Philippa H. Francis-West.Gametogenesis, fertilization, and first week -- Second week: becoming bilaminar and fully implanting -- Third week: becoming trilaminar and establishing body axes -- Fourth week: forming the embryo -- Principles and mechanisms of morphogenesis and dysmorphogenesis -- Fetal development and the fetus as patient -- Development of the skin and its derivatives -- Development of the musculoskeletal system -- Development of the central nervous system -- Development of the peripheral nervous system -- Development of the respiratory system and body cavities -- Development of the heart -- Development of the vasculature -- Development of the gastrointestinal tract -- Development of the urogenital system -- Development of the pharyngeal apparatus and face -- Development of the ears and eyes -- Development of the limbs.
- 2011 SpringerChristian Raulin, Syrus Karsai (editors).Part 1 Basics -- Basic Laser Physics -- Laser-Tissue Interactions -- Intense Pulsed Light Technology -- Part 2 Indications -- Benign Tumors and Organoid Nevi -- Facial Rejuvenation and Other Clinical Applications of Intense Pulsed Light -- Inflammatory Dermatoses: Acne -- Inflammatory Dermatoses: Other than Acne Vulgaris -- Laser-Assisted Liposuction -- Photoepilation of Unwanted Hair Growth -- Pigmentation and Hypopigmentation: Benign Pigmented Lesions -- Pigmentation and Hypopigmentation: Vitiligo and Other Disorders -- Precancerous Conditions and Malignant Tumors -- Scars, Keloids, and Stretch Marks -- Laser Treatment of Tattoos and Other Dyschromia -- Varicose Veins: Endovenous Laser Treatment -- Common Vascular Lesions -- Vascular Lesions: Port Wine Stains -- Vascular Lesions: Hemangiomas -- Rare Vascular Lesions -- Viral Infections -- Wrinkles and Acne Scars: Ablative and Nonablative Facial Resurfacing -- Wrinkles and Acne Scars: Technology-Based Treatment of Periorbital Wrinkles -- Wrinkles and Acne Scars: Fractional Ablative Lasers -- Wrinkles and Acne Scars: Fractional Nonablative Lasers -- Part 3 Special Aspects -- Complications in Laser Surgery and IPL Treatment -- Cooling Techniques -- Ethical Considerations in Aesthetic Medicine -- Photodynamic Therapy -- Quality Standards in Aesthetic Medicine -- Safety/Eye Protection -- Part 4 Afterword -- The Business of Laser Surgery How Our Lives are Challenged by Healthcare Regulations, the FDA, and Quackery -- The Hall of Shame.
- 2011 Springer Protocolsedited by Graeme I. Murray.Laser capture microdissection : methods and applications / Kristen DeCarlo . [and others] -- Laser microdissection for gene expression profiling / Lori A. Field [and others] -- Gene expression using the PALM system / Jian-Xin Lu and Cheuk-Chun Szeto -- Immunoguided microdissection techniques / Michael A. Tangrea [and others] -- Optimized RNA extraction from non-deparaffinized laser-microdissected material / Danny Jonigk [and others] -- Laser capture microdissection for analysis of gene expression in formalin-fixed paraffin-embedded Tissue / Ru Jiang, Rona S. Scott, and Lindsey M. Hutt-Fletcher -- MicroRNA profiling using RNA from microdissected immunostained tissue / Clemens L. Bockmeyer [and others] -- Profiling solid tumor heterogeneity by LCM and biological MS of fresh-frozen tissue sections / Donald J. Johann [and others] -- Amplification testing in breast cancer by multiplex ligation-dependent probe amplification of microdissected tissue / Cathy B. Moelans, Roel A. de Weger, and Paul J. van Diest -- Detection and quantification of MicroRNAs in laser-microdissected formalin-fixed paraffin-embedded breast cancer tissues / Sarkawt M. Khoshnaw [and others] -- Laser capture microdissection applications in breast cancer proteomics / Rene B.H. Braakman [and others] -- Proteomic analysis of laser microdissected ovarian cancer tissue with SELDI-TOF MS / Isabelle Cadron [and others] -- LCM Assisted biomarker discovery from archival neoplastic gastrointestinal tissues / Patricia A. Meitner and Murray B. Resnick -- Purification of diseased cells from Barrett's esophagus and related lesions by laser capture microdissection / Masood A. Shammas and Manjula Y. Rao -- Laser microdissection of intestinal epithelial cells and downstream analysis / Benjamin Funke -- Application of laser microdissection and quantitative PCR to assess the response of esophageal cancer to neoadjuvant chemo-radiotherapy / Claus Hann von Weyhern and Bjorn L.D.M. Brucher -- Oligonucleotide microarray expression profiling of contrasting invasive phenotypes in colorectal cancer / Christopher C. Thorn, Deborah Williams, and Thomas C. Freeman -- Evaluation of gastrointestinal mtDNA depletion in mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) / Carla Giordano and Giulia d'Amati -- Laser microdissection for gene expression study of hepatocellular carcinomas arising in cirrhotic and non-cirrhotic livers / Maria Tretiakova and John Hart -- Laser capture microdissection of pancreatic ductal adeno-carcinoma cells to analyze EzH2 by western blot analysis / Aamer M. Qazi [and others] -- Laser-capture microdissection of renal tubule cells and linear amplification of RNA for microarray profiling and real-time PCR / Susie-Jane Noppert, Susanne Eder, and Michael Rudnicki -- Subcellular renal proximal tubular mitochondrial toxicity with tenofovir treatment / James J. Kohler and Seyed H. Hosseini -- Application of laser-capture microdissection to study renal carcinogenesis / Kerstin Stemmer and Daniel R. Dietrich -- Laser-capture microdissection and transcriptional profiling in archival FFPE tissue in prostate cancer / Ajay Joseph and Vincent J. Gnanapragasam -- Quantitative analysis of the enzymes associated with 5-Fluorouracil metabolism in prostate cancer biopsies / Tomoaki Tanaka -- Microdissection of gonadal tissues for gene expression analyses / Anne Jørgensen, Marlene Danner Dalgaard, and Si Brask Sonne -- Duplex real-time PCR assay for quantifying mitochondrial DNA deletions in laser microdissected single spiral ganglion cells / Adam Markaryan, Erik G. Nelson, and Raul Hinojosa -- Neuronal type-specific gene expression profiling and laser-capture microdissection / Charmaine Y. Pietersen . [et al.] -- Region-specific in situ hybridization-guided laser-capture microdissection on postmortem human brain tissue coupled with gene expression quantification / Rene Bernard, Sharon Burke, and Ilan A. Kerman -- UV-laser microdissection and mRNA expression analysis of individual neurons from postmortem Parkinson's disease brains / Jan Grundemann, Falk Schlaudraff, and Birgit Liss -- Transcriptome profiling of murine spinal neurulation using laser capture microdissection and high-density oligonucleotide microarrays / Shoufeng Cao, Boon-Huat Bay, and George W. Yip -- Probing the CNS microvascular endothelium by immune-guided laser-capture microdissection coupled to quantitative RT-PCR / Nivetha Murugesan [and others] -- Laser-capture microdissection for factor VIII-expressing endothelial cells in cancer tissues / Tomoatsu Kaneko [and others] -- Laser-capture microdissection and analysis of liver endothelial cells from patients with Budd-Chiari syndrome / Selcuk Sozer and Ronald Hoffman -- Laser-capture microdissection of hyperlipidemic/ApoE-/- mouse aorta atherosclerosis / Michael Beer [and others] -- Gene expression profiling in laser-microdissected bone marrow megakaryocytes / Kais Hussein -- Specific RNA collection from the rat endolymphatic sac by laser-capture microdissection (LCM) : LCM of a very small organ surrounded by bony tissues / Kosuke Akiyama [and others] -- Use of laser capture microdissection on adult human articular cartilage for gene expression analysis / Naoshi Fukui, Yasuko Ikeda, and Nobuho Tanaka -- Laser-capture microdissection of developing barley seeds and cDNA array analysis of selected tissues / Johannes Thiel, Diana Weier, and Winfriede Weschke -- Quantitative RT-PCR gene expression analysis of a laser microdissected placenta : an approach to study preeclampsia / Yuditiya Purwosunu [and others].
- 2002 ScienceDirectedited by P. Michael Conn.Also available: Print – 2002
- 2013 SpringerDavid J. Goldberg, editor.This is the second edition of a well-received book that has been revised and updated to reflect the state of the art in laser and light source technology. After an initial chapter describing the latest understanding of laser physics and safety, subsequent chapters consider laser treatment of vascular lesions, laser treatment of pigmented lesions and tattoos, laser removal of unwanted hair, ablative and non-ablative fractional resurfacing, and use of laser treatment for medical purposes. The book is extremely practical and reader friendly. All chapters are very well illustrated, include quick and clear bullet points, and feature a homogeneous structure covering core concepts, currently available technologies, indications and contraindications, an example of a consent form, and the author's personal treatment approaches. The authors are without exception world experts in the field from North America or Europe.
- 2007 ScienceDirectedited by Michael W. Berns, Karl Otto Greulich.Also available: Print – 2007
- 2014 Springer Protocolsedited by Lidia Bakota, Department of Neurobiology, University of Osnabrück, Osnabrück, Germany, Roland Brandt, Department of Neurobiology, University of Osnabrück, Osnabrück, Germany.
- 2016 Thieme-Connect[edited by] William H. Truswell.
- 2009 ClinicalKeyedited by David J. Goldberg.Vascular Lesions -- Leg Veins -- Pigmented Lesions and Tattoos -- Laser Treatment for Scars -- Treatment of Actinic Keratoses and Nonmelanoma Skin Cancer -- Acne -- Psoriasis -- Photodynamic Therapy-Cosmetic -- Laser Hair Removal.
- 2013 ClinicalKeyedited by George J. Hruza, Mathew M. Avram.Now available as one streamlined volume, Lasers and Lights provides the most advanced treatments for rejuvenation, skin resurfacing, scars, and hair removal. You'll focus on procedural how-to's and get step-by-step advice on proper techniques, pitfalls, and tricks of the trade, so you can incorporate the very latest in lasers and lights into your busy practice! Expand your repertoire and refine your skills with Lasers and Lights, which contains a wealth of color illustrations and photographs depicting cases as they appear in practice.
- 2009 ClinicalKeyedited by Barry DiBernardo, Jason N. Pozner.Aging skin: intrinsic aging and chronic photoaging -- CO₂ laser applications: new fractional and traditional CO₂ laser resurfacing and CO₂ laser blepharoplasty -- Erbium and other ablative technologies -- Fractionated lasers -- Intense pulsed light -- Radiofrequency -- Laser hair removal -- Laser acne treatment -- Advances in light-emitting diodes (LED) technology and therapy -- Laser lipolysis --Non-invasive body contouring -- Low level laser therapy in hair loss -- Clinical photography for laser and light-based therapies.
- 2015 SpringerO. Topaz, editor.Preface -- Laser physics and laser sources for cardiovascular applications -- Optic fibers and mechanical properties of laser catheters -- Landmarks along the introduction of laser to cardiovascular therapy -- Laser-thrombus interaction: from basic research to clinical utilization in the management of cardiovascular diseases -- Laser for treatment of acute coronary syndromes -- Laser for management of ST-elevation acute myocardial infarction -- Laser for revascularization of complex targets: old SVGs, CTO, left main disease, stent restenosis -- Laser utilization for synergistic technology strategy for coronary revascularization: laser and directional rotablation; laser combined with drug eluting balloon -- Laser for revascularization of peripheral arterial disease- SFA, renal, subclavian, carotid arteries -- Laser for infra-popliteal revasculariztion -- TMR- physiology, pathology and basic research concepts -- TMR-endovascular and surgical techniques and clinical outcomes -- Laser application for venous thrombosis -- Laser for IVC filter removal -- Laser for interventional electrophysiology ? extraction and removal of pacemaker and AICD leads -- Laser for treatment of cardiac arrhythmias -- Laser application for treatment of congenital heart disease -- Nursing perspectives of cardiovascular laser procedures -- Laser safety in the cardiovascular suite and the operation room -- Laser induced cardiovascular complications : mechanisms, recognition and management -- Laser in cardiovascular veterinary medicine.
- 2011 SpringerKeyvan Nouri (editor).Laser-Tissue Interactions -- Laser Safety: Regulations, Standards and Practice Guidelines -- Lasers for Treatment of Vascular Lesions -- Laser for Scars -- Laser Treatment of Leg Veins -- Lasers and Lights for Treating Pigmented Lesions -- Laser Treatment of Tattoos -- Laser for Hair Removal -- Lasers for Resurfacing -- Fractional Photothermolysis -- Plasma Resurfacing -- Sub-Surfacing Lasers -- Non-invasive Rejuvenation/Skin Tightening: Light-Based Devices -- Laser and Light Therapies for Acne -- Lasers for Psoriasis and Hypopigmentation -- Lasers and Lights for Adipose Tissue and Cellulite -- Intense Pulse Light (IPL) -- Photodynamic Therapy -- Light-Emitting Diode Phototherapy in Dermatological Practice -- Laser and Light for Wound Healing Stimulation -- Lasers in Hair Growth and Hair Transplantation -- Reflectance-Mode Confocal Microscopy in Dermatological Oncology -- Laser Clinical and Practice Pearls -- The Selection and Education of Laser Patients -- Anesthesia for Laser Surgery -- Laser Application for Ethnic Skin -- Laser Applications in Children -- Dressings/Wound Care for Laser Treatment -- Prevention and Treatment of Laser Complications -- Ethical Issues -- Medicolegal Issues (Documentation/Informed Consent) -- Psychological Aspects to Consider Within Laser Treatments -- Photography of Dermatological Laser Treatment -- Online Resources for Dermatologic Laser Therapies -- Starting a Laser Practice -- Research and Future Directions -- Laser/Light Applications in Ophthalmology: Visual Refraction -- Laser/Light Applications in Ophthalmology: Posterior Segment Applications -- Laser/Light Application in Ophthalmology: Control of Intraocular Pressure -- Laser/Light Application in Dental Procedures -- Laser/Light Applications in Otolaryngology -- Laser/Light Applications in Gynecology -- Laser/Light Applications in General Surgery -- Laser/Light Applications in Urology -- Lasers in Cardiology and Cardiothoracic Surgery -- Laser/Light Applications in Neurology and Neurosurgery -- Laser/Light Applications in Anesthesiology.
- 2002 CRCnetBASEedited by Ronald W. Waynant ; foreword by the late Dr. Leon Goldman.Also available: Print – 2002
- 2007 SpringerMarkolf H. Niemz.
- 2010Christopher Koerner Sramek.Since its introduction nearly 40 years ago, laser photocoagulation has been the standard of care for treatment of numerous retinal pathologies. Recently, new approaches have been introduced for more selective targeting of various retinal layers, including patterned scanning photocoagulation, selective retinal therapy, and sub-lethal treatment. Despite its broad use in clinical practice, there remains a need for the quantitative description of laser-tissue interactions involved in retinal phototherapy. A unified description of various treatment regimes and associated mechanisms of tissue damage would allow for optimization of laser parameters to improve selectivity and safety of retinal photocoagulation, and for avoidance of undesirable collateral damage. The presented work describes an investigation into the dynamics of the retinal response to hyperthermia and vaporization. A finite-element computational model of photocoagulation and rupture was constructed based on experimental measurements of laser interactions with tissue, and verified in vivo in the millisecond time domain. Two approaches towards improvement of tissue heating uniformity were studied: spatial and temporal modulation of the treatment beam. After optimization using the computational model, beam shaping and pulse modulation systems were constructed. Experimental studies in vivo confirmed improvements in safety of the retinal treatment, potentially allowing for reductions in treatment time, thermal damage extent, and perceived pain. In addition, tissue response to sub-lethal thermal stress in the retina was explored using expression of heat shock protein in an animal model. Computational modeling of the corresponding treatment regime demonstrated that a similar response is likely to occur in clinical application of sub-lethal exposures. Photo-mechanical interactions in the retina were investigated in model systems and in vivo with microsecond-range exposures. The dominant mechanisms of tissue damage were identified and the corresponding limits of the safe therapeutic window were computed over a broad range of pulse durations - from microseconds to seconds. An understanding of the thermal and mechanical interactions involved in laser heating of the retina allows for the realization of safer and more selective treatment regimes. All three mechanisms investigated in the current study -- photocoagulation, photomechanical interactions and sub-lethal hyperthermia -- play a role in clinical treatment. The developed quantitative models of these interactions have immediate applicability to clinical practice, providing guidance towards optimization of retinal phototherapy, evaluation of retinal safety, and development of new clinical applications.
- 2007 Ovideditors, Robert S. Feder, Christopher J. Rapuano.Ch. 1 Basic LASIK -- Ch. 2 Equipment -- Ch. 3 Role of mitomycin-c in keratorefractive surgery -- Ch. 4 Retreatment of patients after primary refractive surgery -- Ch. 5 LASIK complications and management -- Ch. 6 Alternatives to LASIK refractive surgery -- Ch. 7 Case selection -- Ch. 8 Self-assessment test.
- 2013 Ovideditor, Robert S. Feder.Section I. LASIK fundamentals -- section II. Diagnostic equipment -- section III. Flap-making equipment -- section IV. Excimer lasers -- section V. Management of postsurgical problems -- section VI. Other surgical considerations -- section VII. Study section -- section VIII. International perspectives in refractive surgery.
- 2011Adam Richard Rosenblatt.Last Rights is a political, historical, and philosophical study of the scientific investigation of mass graves in the wake of genocides and other mass killings. In the mid-1980s, an independent group of anthropologists formed in Argentina to exhume the anonymous graves of "disappeared" victims of state repression. Since then, a number of human rights organizations have built on this model, assembling teams of forensic anthropologists, archaeologists, pathologists, geneticists, and other experts capable of documenting evidence of war crimes and identifying dead victims. In the 1990s, after genocidal violence erupted in both Rwanda and the disintegrating Yugoslavia, international tribunals called upon forensic experts from Latin America, the United States, and Europe to exhume mass graves in both countries, making the forensic investigation of human rights violations a global project. Since then, expectations have steadily grown among survivor communities, as well as international institutions and observers, that mass graves will be exhumed, evidence gathered, and bodies identified. Using case studies from Argentina, the former Yugoslavia, Poland, Spain, and other post-conflict nations, as well as reports, articles, memoirs, and interviews with forensic experts, this dissertation paints a detailed portrait of the purposes international forensic investigations serve. Courts and tribunals, transitional governments, victims' families and other mourners all have different stakes in discovering the truths buried in mass graves, and thus place different expectations and demands on forensic teams. This complex landscape of stakeholders has added a whole new set of priorities to the traditional conception of forensics as science used in the service of the law: among them the "humanitarian" effort to discover the fate of missing persons and return their bodies to families, the construction of an objective and scientific historical narrative, and training local forensic experts and authorities to deal with the legacy of violence. Yet forensic teams have also met with fierce objections from some families of the missing and other communities around mass graves. These objections pose a challenge to the universalism of global forensic investigation--the idea that forensic science can serve the same purposes in every post-conflict setting. However, a detailed study of the specific arguments behind these challenges can create opportunities to develop clearer explanations of what forensic investigations accomplish, as well as foster more nuanced and democratic interactions with local stakeholders. In its final chapters, the dissertation pursues a new dimension of ethical inquiry, asking what forensic investigations do for the dead victims of atrocity. Drawing on various approaches from political and moral theory, it first explores the ethical framework most familiar to international forensic teams: human rights. Human rights are a powerful language for describing the violations that have been inflicted on the now-dead victims, as well as the claims of living mourners. As a description of the guarantees that can be made to dead bodies, however, they overreach. Dead bodies can, however, be cared for in various ways, even when they are unidentified or incomplete. Many of the practices of forensic experts are already directed towards this care-giving relationship with the dead, an intimate and powerful attempt to reestablish the connections between their bodies, possessions, and their mourners, as well as to reverse the effects of violence upon them.
- 2010David G. Hunter, Constance E. West.Basic principles -- Vergence, lenses, objects, and images -- The model eye -- Visual acuity testing -- Refraction and optical dispensing -- Lens effectivity and vertex distance -- Accommodation, presbyopia, and bifocals -- Astigmatism -- Aberrations, distortions, and irregularities -- Contact lenses -- Intraocular lenses -- Refractive surgery -- Magnification and telescopes -- Low vision -- Mirrors -- Prisms and diplopia -- Instruments -- Good people, bad optics : the dissatisfied patient -- Important formulas.
- 2011 ClinicalKey[edited by] Chummy S. Sinnatamby.Upper limb -- Lower limb -- Thorax -- Abdomen -- Head and neck and spine -- Central nervous system -- Osteology of the skull and hyoid bone.
- 2006[edited by] Chummy S. Sinnatamby.
- 2008 SpringerP. Rubin, L.S. Constine, L.B. Marks, P. Okunieff, (eds.).
- 2009 Springeredited by Stewart Goldman, Christopher Turner.Part I. Overview of brain tumor survivorship -- Introduction to brain tumor survivorship and historical perspective / Stewart Goldman and Christopher D. Turner -- Late effects of neurosurgery / Arthur J. DiPatri, Martin Pham, and Kenji Muro -- Late effects of CNS radiation therapy / Helen A. Shih, Jay S. Loeffler, and Nancy J. Tarbell -- Late effects of chemotherapy / Sridharan Gururangan -- Late effects of stem cell transplantation in brain tumor survivors / Karina Danner-Koptik, David A. Jacobsohn, and Kimberley J. Dilley -- Effect of cancer treatment on neural stem and progenitor cells / Jörg Dietrich and Santosh Kesari -- The pediatric brain tumor late effects clinic / Kimberly J. Dilley and Barbara Lockart -- Part II. Medical late effects of brain tumor treatment -- Neurological complications in adults / Michelle Monje and Patrick Y. Wen -- Neurological complications in children / Sonia Partap and Paul Graham Fisher -- Strokes among childhood brain tumor survivors / Daniel C. Bowers -- Endocrine late effects: manifestations and treatments / Jason R. Fangusaro and Elizabeth Eaumann Littlejohn -- Ocular consequences and late effects of brain tumor treatments / María E. Echevarría and Joanna L. Weinstein -- Auditory late effects of chemotherapy / Anna K. Meyer and Nancy M. Young -- Reproductive health issues in survivors of childhood and adult brain tumors / Tress Goodwin, B. Elizabeth Delasobera, and Paul Graham Fisher -- Cancer predisposition syndromes / Joanna L. Weinstein, Kanyalakshmi Ayyanar, and Melody A. Watral -- Secondary neoplasms following treatment for brain tumors / Joanna L. Weinstein, Kanyalakshmi Ayyanar, and Melody A. Watral.Also available: Print – 2009
- Late sodium current : emerging involvement in cardiovascular disease and role as a target for potential new therapies in angina2006 HighWireedited by P.A. Poole-Wilson, L. Tavazzi.
- 2007 Springeredited by Janos Minarovits, Eva Gonczol, Tibor Valyi-Nagy.
- 2009 SpringerRaphael C. Wong, Harley Y. Tse, editors.
- 2013 SpringerUri Gophna, editor."Although the phenomenon of lateral gene transfer has been known since the 1940s, it was the genomics era that has really revealed the extent and many facets of this evolutionary/genetic phenomenon. Even in the early 2000s with but a handful of genomes available, it became clear that the nature of microorganisms is full of genetic exchange between lineages that are sometimes far apart. The years following this saw an explosion of genomic data, which shook the "tree of life" and also raised doubts about the most appropriate species concepts for prokaryotes. This book represents the manyfold contributions of LGT to the evolution of micro and, to an extent, macroorganisms by focusing on the areas where it has the largest impact: metabolic innovations and adaptations and speciation." Back cover.
- 2014 SpringerSheryl Coombs, Horst Bleckmann, Richard R. Fay, Arthur N. Popper, editors.The Lateral Line System provides an overview of the key concepts and issues surrounding the development, evolution, neurobiology, and function of the lateral line, a fascinating yet somewhat enigmatic flow-sensing system. The book examines the historical precedence for linking the auditory and lateral line systems, its structure and development, use of the lateral line system of zebrafish as a model system, physical principles governing the response properties of the lateral line, the behavioral relevance of this sensory system to the lives of fish, and an examination of how this information
- 2008 Springeredited by Havid́́án Rodríguez, Sáenz, Rogelio, Cecilia Menjívar ; with forewords by Clara E. Rodríguez, Douglas S. Massey.Theoretical and methodological issues of Latina/o research / Nestor Rodríguez -- New Latino destinations / Manuel A. Vásquez, Chad E. Seales, and Marie Friedmann Marquardt -- Latino incorporation in the United States in local and transnational contexts / Robert Courtney Smith -- Demographic patterns : age structure, fertility, mortality, and population growth / Jorge del Pinal -- Through children's eyes : families and households of Latino children in the United States / Jennifer E. Glick and Jennifer Van Hook -- U.S. Latinos/as and the "American dream" : diverse populations and unique challenges in housing / Eileen Diaz McConnell -- Latino health paradoxes : empirical evidence, explanations, future research, and implications / Dolores Acevedo-Garcia and Lisa M. Bates -- Latino crime and delinquency in the United States / Ramiro Martinez, Jr. -- The educational experiences of Latinos in the United States / William Vélez -- Latinos in the United States labor market / Lisa Catanzarite and Lindsey Trimble -- Latino/a entrepreneurship in the United States : a strategy of survival and economic mobility / Zulema Valdez -- Income, earnings, and poverty : a portrait of inequality among Latinos/as in the United States / Alberto Dávila, Marie T. Mora, and Alma D. Hales -- Mapping the dynamic terrain of U.S. Latina/o media research / Isabel Molina Guzmán -- As the Latino/a world turns : the literacy and cultural production of transnational latinidades / Ana Patircia Rodríguez -- Religion and religiosity / Miguel A. De La Torre -- Latinos/os (in) on the border / Emily Skop, Brian Gratton, and Myron P. Gutmann -- Entre nosotras/os : theorizing, researching, and constructing cross-Latina/o relations in the United States / Gilda L. Ochoa -- Beyond gender dichotomies : toward a new century of gendered scholarship in the Latina/o experience / Maura I. Toro-Morn -- Adelante mujer : Latina activism, feminism, and empowerment / Denise A. Segura and Elisa Facio -- Latinas and Latinos, sexuality, and society : a critical sociological perspective / Gloria González-Lopez and Salvador Vidal-Ortiz -- Latino partisanship, political activity and vote choice / Kim Geron and Melissa R. Michelson -- Political orientations and Latino immigrant incorporation / Sarah Allen Gershon and Adrian D. Pantoja -- Political mobilization and activism among Latinos/as in the United States / Christian Zlolniski -- Unions and the unionization of Latinas/os in the United States / Héctor L. Delgado.
- 2014a poll conducted by the Harvard School of Public Health, the Robert Wood Johnson Foundation and NPR.
- 2014a poll conducted by the Harvard School of Public Health, the Robert Wood Johnson Foundation and NPR.
- 2008 SpringerDeepayan Sarkar.
- 2006Jie Jack Li.Cancer drugs: from nitrogen mustards to Gleevec -- Drugs to kill germs -- Cardiovascular drugs: from nitroglycerin to Lipitor -- Sex and drugs -- Drugs of the mind -- Diabetes drugs -- Anesthetics -- Anti-inflammatory drugs -- Reflections.
- 2002 CRCnetBASEedited by Maria Lis-Balchin.
- 2010Christopher Scott Hemphill.This dissertation examines the law and economics of generic drug entry, and the problems that arise from specific U.S. regulatory arrangements that govern innovation and competition in the market for patented pharmaceuticals. As Chapter 1 explains, competitive entry by generic drug makers is limited by both patents and industry-specific regulation, which together provide the means for brand-name drug makers to avoid competition and thereby recoup large investments in research, development, and testing. At the same time, the complex rules of the Hatch-Waxman Act furnish a pathway by which generic drug makers may challenge the validity or scope of brand-name patents, with a view to entering the market with a competing product prior to patent expiration. The subsequent chapters examine several aspects of the competitive interaction between brand-name and generic drug makers. Chapter 2 analyzes settlements of patent litigation between brand-name and generic drug makers, in which the brand-name firm pays the generic firm in exchange for delayed market entry. Such pay-for-delay settlements are an important, unresolved question in U.S. antitrust policy. The analysis reveals that the pay-for-delay settlement problem is more severe than has been commonly understood. Several specific features of the Act--in particular, a 180-day bounty granted to certain generic drug makers as an incentive to pursue pre-expiration entry--widen the potential for anticompetitive harm from pay-for-delay settlements, compared to the usual understanding. In addition, I show that settlements are "innovation inefficient" as a means of providing profits and hence ex ante innovation incentives to brand-name drug makers. To the extent that Congress established a preferred tradeoff between innovation and competition when it passed the Act, settlements that implement a different, less competition-protective tradeoff are particularly problematic from an antitrust standpoint. Chapter 3 synthesizes available public information about pay-for-delay settlements in order to offer a new account of the extent and evolution of settlement practice. The analysis draws upon a novel dataset of 143 such settlements. The analysis uncovers an evolution in the means by which a brand-name firm can pay a generic firm to delay entry, including a variety of complex "side deals" by which a brand-name firm can compensate a generic firm in a disguised fashion. It also reveals several novel forms of regulatory avoidance. The analysis in the chapter suggests that, as a matter of institutional choice, an expert agency is in a relatively good position to conduct the aggregate analysis needed to identify an optimal antitrust rule. Chapter 4 examines the co-evolution of increased brand-name patenting and increased generic pre-expiration challenges. It draws upon a second novel dataset of drug approvals, applications, patents, and other drug characteristics. Its first contribution is to chart the growth of patent portfolios and pre-expiration challenges. Over time, patenting has increased, measured by the number of patents per drug and the length of the nominal patent term. During the same period, challenges have increased as well, and drugs are challenged sooner, relative to brand-name approval. The analysis shows that brand-name sales, a proxy for the profitability of the drug, have a positive effect on the likelihood of generic challenge, consistent with the view that patents that later prove to be valuable receive greater ex post scrutiny. The likelihood of challenge also varies by patent type and timing of expiration. Conditional on sales and other drug characteristics, drugs with weaker patents, particularly those that expire later than a drug's basic compound patent, face a significantly higher likelihood of challenge. Though the welfare implications of Hatch-Waxman patent challenge provisions are complicated, these results suggest these challenges serve a useful purpose, in promoting scrutiny of low quality and late-expiring patents.
- 2006 ScienceDirectby Graham Dukes.
- 2007 CRCnetBASEDaniel A. Bronstein.
- Charles Calleros.
- issued by Physical Therapy Examining Committee, Board of Medical Quality Assurance.Also available: Print – 1979-
- 2012 Springer Protocolsedited by Loralie J. Langman and Chistine L.H. Snozek.Introduction to drug testing : the expanding role of mass spectrometry / Catherine Hammett-Stabler and Steven W. Cotten -- LC-MS vs. GC-MS, online extraction systems, advantages of technology for drug screening assays / Pierre Marquet -- LC-MS/MS techniques for high-volume screening of drugs of abuse and target drug quantitation in urine/blood matrices / Jeff C. Eichhorst [and others] -- Benzodiazepines and metabolites from biological fluids by liquid chromatography electrospray tandem mass spectrometry / Cynthia L. Morris-Kukoski, Jason E. Schaff, and Louis J. Reda -- Opiate screening and quantitation in urine/blood matrices using LC-MS/MS techniques / Jeff C. Eichhorst [and others] -- Synthetic opioid analysis by LC-MS/MS / David M. Garby and Lynn A. Cheryk -- Determination of cannabinoids using liquid chromatography with mass spectrometric detection / Oscar Quintela and Dennis J. Crouch -- Cocaine and metabolites by LC-MS/MS / Christine L.H. Snozek, Matthew W. Bjergum, and Loralie J. Langman -- Quantitation of amphetamine-type stimulants by LC-MS/MS / Robert A. Middleberg and Joseph Homan -- Detection of prohibited substances by liquid chromatography tandem mass spectrometry for sports doping control / Brian D. Ahrens, Borislav Starcevic, and Anthony W. Butch -- LC-MS/MS screen for xenobiotics and metabolites / Francois-Ludovic Sauvage and Pierre Marquet -- Qualitative identification of rodenticide anticoagulants by LC-MS/MS / Robert A. Middleberg and Joseph Homan -- Hypoglycemic agent screening by LC-MS/MS / Eric W. Korman, Loralie J. Langman, and Christine L.H. Snozek -- LC-MS/MS method for the detection of common laxatives / Robert A. Middleberg and Joseph Homan -- Simultaneous determination of cyclosporine, sirolimus, and tacrolimus in whole blood using liquid chromatography-tandem mass spectrometry / Uttam Garg, Ada Munar, and C. Clinton Frazee III -- Quantification of tricyclic antidepressants using UPLC-MS/MS / Kamisha L. Johnson-Davis [and others] -- Quantitation of first- and second-generation antipsychotics by LC-MS/MS / Elizabeth R. Kiely and Heather M. Antonides -- Analysis of selected anticonvulsants by high performance liquid chromatography-tandem mass spectrometry / Jennifer A. Collins and Gregory C. Janis -- Therapeutic drug monitoring of tamoxifen using LC-MS/MS / Simone M. Tchu, Kara L. Lynch, and Alan H.B. Wu.
- 2010 Springer Protocolsedited by Pedro R. Cutillas, John F. Timms.Approaches and applications of quantitative LC-MS for proteomics and activitomics / Pedro R. Cutillas and John F. Timms -- Overview of quantitative LC-MS techniques for proteomics and activitomics / John F. Timms and Pedro R. Cutillas -- Instrumentation for LC-MS/MS in proteomics / Robert Chalkley -- Bioinformatics for LC-MS/MS-based proteomics / Richard J. Jacob -- Analysis of post-translational modifications by LC-MS/MS / Hannah Johnson and Claire E. Eyers -- In-depth analysis of protein phosphorylation by multidimensional ion exchange chromatography and mass spectrometry / Maria P. Alcolea and Pedro R. Cutillas -- Mapping of phosphorylation sites by LC-MS/MS / Bertran Gerrits and Bernd Bodenmiller -- Analysis of carbohydrates on proteins by offline normal-phase liquid chromatography MALDI-TOF-MS/MS / Theodora Tryfona and Elaine Stephens -- Selected reaction monitoring applied to quantitative proteomics / Reiko Kiyonami and Bruno Domon -- Basic design of MRM assays for peptide quantification / Andrew James and Claus Jorgensen -- Proteome-wide quantitation by SILAC / Kristoffer T.G. Rigbolt and Blagoy Blagoev -- Quantification of proteins by iTRAQ / Richard D. Unwin -- Quantification of proteins by label-free LC-MS/MS / Yishai Levin and Sabine Bahn -- Protocol for quantitative proteomics of cellular membranes and membrane rafts / Andrew J. Thompson and Ritchie Williamson -- Organelle proteomics by label-free and SILAC-based protein correlation profiling / Joern Dengjel, Lis Jakobsen, and Jens S. Andersen -- Mapping protein-protein interactions by quantitative proteomics / Joern Dengjel, Irina Kratchmarova, and Blagoy Blagoev -- Analysis of serum proteins by LC-MS/MS / Sarah Tonack, John P. Neoptolemos, and Eithne Costello -- Urinary proteome profiling using 2D-DIGE and LC-MS/MS / Mark E. Weeks -- Analysis of peptides in biological fluids by LC-MS/MS / Pedro R. Cutillas -- Quantification of protein kinase activities by LC-MS / Maria P. Alcolea and Pedro R. Cutillas -- A protocol for top-down proteomics using HPLC and ETD/PTR-MS / Sarah R. Hart.
- 2011 ScienceDirectPaul Mushak.The book presents a detailed assessment of the health science of lead and the human health risk assessment models for lead's human health impacts, followed by an account of various regulatory efforts in the United States and elsewhere to eliminate or reduce human toxic exposures to lead. The science of lead as presented here covers releases of lead into the environment, lead's movement through the environment to reach humans who are then exposed, and the spectrum of toxic effects, particularly low-level toxic effects, on the developing central nervous system of the very young child. The section on human health risk assessment deals with quantifying not only the dose-response relationships that underlie toxic responses to lead in sensitive populations but also with the likelihood of toxic responses vis-vis environmental lead at some level of exposure. This section includes a treatment of computer models of lead exposure, particularly those that use lead in whole blood as a key measure. Various models convert lead intake via various body compartments into measures of body lead burden. Such measures are then directly related to severity of injury. The final section of the book deals with past and present regulatory efforts to control lead releases into the human environment. Current control efforts present a mixed picture. The most problematic issue is the continued presence of lead paint in older housing and lead in soils of urban and mining industry communities. Comprehensive assessment of the three major facets of the public health problem of lead: the voluminous science, the risk assessment approaches, and approaches to controlling lead as a public health problem. Integration of the above three elements to provide a coherent whole Provides a single source of information that will be extremely valuable to all professionals working in areas impacted by this toxic substance.
- 2016 NLM
- Laboratory and diagnostic tests with nursing implications. 8th ed. — Lead medical surveillance [algorithm] (119)
- Lead molecules from natural products : discovery and new trends — Lewin, Weinstein, and Riddell's Gastrointestinal pathology and its clinical implications. 2nd ed. (119)
- Lewin's Genes. X — Little SAS book for Enterprise Guide 4.2 (119)
- Liver and biliary tract surgery : embryological anatomy to 3D-imaging and transplant innovations — Lysosomes and lysosomal diseases (119)
- Harrison's Principles of Internal Medicine
- AAP Red Book Online
- Robbins & Cotran Pathologic Basis of Disease
- Sabiston Textbook of Surgery
- Nelson's Textbook of Pediatrics
- Surgical Exposures in Orthopaedics
- Mandell, Douglas, & Bennett's Principles & Practice of Infectious Diseases
- Red Book Online
- ICU Book
- Primary Care Medicine
- Campbell-Walsh Urology
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