Lane Medical Library

The Continuing Fascination with Jaks and Stats: An Introduction /Thomas Decker and Mathias Müller --Regulation of JAKs: Insights Gleaned from the Functional Protein Domains /Claude Haan, Daniela Ungureanu, Tuija Pekkala, Olli Silvennoinen and Serge Haan --Nuclear Functions of the Janus Kinases /Mark A. Dawson and Andrew J. Bannister --Self-association of STAT Proteins from Monomers to Paracrystals /Mathias Droescher and Uwe Vinkemeier --How Stats Interact with the Molecular Machinery of Transcriptional Activation /Amanda M. Jamieson, Matthias Farlik and Thomas Decker --Nongenomic Functions of STAT3 /Daniel J. Gough, Pravin Sehgal and David E. Levy --Evolution of Jak and Stat Proteins /Claus Vogl, Priyank Shukla and Ingo Ebersberger --JAK/STAT and Chromatin Regulation in Drosophila /Kriti Gaur and Willis X. Li --JAK/STAT Signaling and Invertebrate Immune Responses /Feng Zhou and Hervé Agaisse --Stat5 as a Hematopoietic Master Regulator for Differentiation and Neoplasia Development /Harini Nivarthi, Katrin Friedbichler and Richard Moriggl --Regulation of Dendritic Cell Development by STATs /Haiyan S. Li and Stephanie S. Watowich.STAT Transcription Factors: Controlling All Aspects of NK Cell Biology /Eva Maria Putz, Eva Zebedin and Veronika Sexl --Function of JAKs and STATs in Lymphocytes: Bench to Bedside /Alejandro Villarino, Xiang-Ping Yang, Kiyoshi Hirahara, Yuka Kanno and John J. O' Shea, et al. --The Role of Janus Kinases in Hematopoietic Malignancies /Damla Olcaydu and Robert Kralovics --Activation of Janus Kinases During Tumorigenesis /Jeffrey W. Schmidt and Kay-Uwe Wagner --STAT1 and STAT3 Transcription Factors in Inflammation-associated Colon Cancer /Paulina Rampetsreiter and Robert Eferl --Universal and Specific Functions of STAT3 in Solid Tumours /Lidia Avalle, Gabriella Regis and Valeria Poli --Impact of STAT5 on Normal Tissue Development and Cancer /Maria M. Caffarel and Christine J. Watson --Crosstalk with the Jak-STAT Pathway in Inflammation /Lionel B. Ivashkiv --Activation and Inhibition of JAK-STAT Signal Transduction by RNA Viruses /Curt M. Horvath --Multifaceted Antiviral Actions of Interferon-stimulated Gene Products /Birgit Strobl, Nicole R. Leitner and Mathias Müller --Interferon Regulation of the Innate Response to Bacteria /Ali Abdul-Sater and Christian Schindler.

Basic concepts in immunology -- Innate immunity -- Antigen recognition by B-cell and T-cell receptors -- The generation of lymphocyte antigen receptors -- Antigen presentation to T lymphocytes -- Signaling through immune system receptors -- The development and survival of lymphocytes -- T cell-mediated immunity -- The humoral immune response -- Dynamics of adaptive immunity -- The mucosal immune system -- Failures of host defense mechanism -- Allergy and hypersensitivity -- Autoimmunity and transplantation -- Manipulation of the immune response -- Evolution of the immune system.

History and present status of gamma knife radiosurgery in Japan / S. Otto -- Dose selection for optimal treatment results and avoidance of complications / H. Nagano ... [et al.] -- Gamma knife radiosurgery for arteriovenous malformations: the furukawa experience / H. Jokura ... [et al.] -- Radiosurgery for cavernous malformations in basal ganglia, thalamus and brainstem / Y. Kida -- Radiosurgery for dural arterio-venous fistula / Y. Kida -- Gamma knife radiosurgery for vestibular schwannomas / S. Fukuoka ... [et al.] -- Long-term results of gamma knife radiosurgery for 100 consecutive cases of craniopharyngioma and a treatment strategy / T. Kobayashi -- Long-term results of stereotactic gamma knife radiosurgery for pituitary adenomas : specific strategies for different types of adenoma / T. Kobayashi --Gamma knife radiosurgery for skull-base meningiomas / M. Takanshi -- Other skull-base tumors / H.K. Inoue -- Radiosurgery for intracranial gliomas / Y. Kida, M. Yoshimoto, T. Hasegawa -- Gamma knife radiosurgery for other primary intra-axial tumors / Y. Iwai, K. Yamanaka-- Metastatic brain tumors : lung cancer / T. Serizawa -- Gamma knife radiosurgery for brain metastases of non-lung cancer origin : focusing on multiple brain lesions / M. Yamamoto, B.E. Barfod, Y. Urakawa -- Treatment of functional disorders with gamma knife thalamotomy / C. Ohye, T. Shibazaki -- Trigeminal neuralgia / M. Hayashi.

Introduction -- Fundamentals of neuronal excitability relevant to seizures and epilepsy -- Mechanisms of seizures susceptibility and epileptogenesis -- Epilepsy genes and development -- Epilepsy therapeutics.

"The science and practice of medicine has undergone a fundamental change as a result of large-scale genome projects that led to the sequencing of a number of important microbial, plant and animal genomes in the last 5 years. This book aims to combine industry standard software engineering and design principles, genomics and bioinformatics and cancer research. It focuses on creating and integrating practical, useful tools for the scientific community in the context of real-life, real-value biomedical problems that researchers face on a routine basis, rather than being just a didactic exercise in learning a programming platform. The book leverages technologies for molecular biology, genomics and bioinformatics and cancer research developed by the NIH, NCI-Center for Bioinformatics (NCICB), the National Center for Biotechnology Information (NCBI, a division of the National Library of Medicine (NLM) at the NIH) and Stanford University."--Publisher.

Part I. Getting started with JavaScript -- Part II. JavaScript tutorial -- Part III. Document objects reference -- Part IV. JavaScript core language reference -- Part V. Appendixes -- Part VI. Bonus chapters.

Introduction to JavaScript -- Core JavaScript -- Client-side JavaScript -- Core JavaScript reference -- Client-side JavaScript reference -- W3C DOM reference -- Class, property, method, and event handler index.

Air Force-related jet fuel toxicology research (1991-2010) / Walter J. Kozumbo -- Jet fuel composition / Tim Edwards -- The toxicity and underlying mechanism of jet propulsion fuel-8 on the respiratory system / Simon S. Wong and Mark L. Witten -- Neurotoxicological and neurobehavioral effects from exposure to jet fuels / Glenn D. Ritchie -- Differential protein expression following JP-8 jet fuel exposure / Frank A. Witzmann and Mark L. Witten -- Immune modulation by dermal exposure to jet fuel / Gerardo Ramos and Stephen E. Ullrich -- Absorption, penetration, and cutaneous toxicity of jet fuels and hydrocarbon components / James E. Riviere, Alfred O. Inman, and Nancy Monteiro-Riviere -- Methods of assessing skin irritation and sensitization of jet fuels / R. Jayachandra Babu, Ram Patlolla, and Mandip Singh -- Understanding systemic and local toxicity of JP-8 after cutaneous exposures / James N. McDougal, James V. Rogers, and Richard Simman -- The effects of aerosolized JP-8 jet fuel exposure on the immune system: a review / David T. Harris -- The involvement of poly(ADP-ribosyl)ation in defense against JP-8 jet fuel and other chemical toxicants / Luis A. Espinoza ... [et al.] -- Evaluation of methods used to generate and characterize jet fuel vapor and aerosol for inhalation toxicology studies / Raphaël T. Tremblay, Sheppard A. Martin, and Jeffrey W. Fisher -- Genetic damage in the blood and bone marrow of mice treated with JP-8 jet fuel / Vijayalaxmi -- Computational analyses of JP-8 fuel droplet and vapor depositions in human upper airway models / Clement Kleinstreuer and Zhe Zhang -- Human exposure to Jet Propellant-8 / Raymond H. Tu and Terence H. Risby.

Preoperative assessment / Maryhelen Miller and Glenn Beauman -- Cardiovascular pharmacological agents / Paul K. Simmonds, Jr., Danial Nyhan, and Dan E. Berkowitz -- Coronary artery disease / Tain-Yen Hsia, Eric A. Peck, and John V. Conte -- Valvular heart disease / David J. Caparelli and John V. Conte -- Diseases of the aorta / Glen D. Quigley, Jason A. Williams, and John V. Conte -- Surgical treatment of cardiac arrhythmias / Ashish S. Shah and William A. Baumgartner -- Heart transplantation and treatment of end-stage heart disease / Jason A. Williams and Brian T. Bethea -- Mechanical devices / Pramod Bonde and John V. Conte -- Postoperative hemodynamic management / Todd Dorman and Daniel Nyhan -- Hemostasis, coagulopathy, and tamponade / Ala' Sami Haddadin Nauder Farraday -- Fluid, electrolyte, and renal function / Jeffrey M. Dodd-O -- Postoperative myocardial ischemia / Edward W. Verde -- Postoperative pulmonary management / Kelly Grogan -- Management of postoperative cardiac arrhythmias / Elizabeth Martinez ... [et al.] -- Postoperative infection in cardiac surgery / Theresa L. Hartsell -- Neurologic sequelae of cardiac surgery / James Weller -- Anticoagulation / Sue Aumick, Valerie Elliot, and Gloria Peithman -- Physical rehabilitation / Melissa Trottman and Amy Pippenger -- Special care issues / Jennifer Moyer, Christina Cafeo, and Mary Lohmann-Edwards.

I. Women's Health Care -- Primary and Preventive Care -- Breast Diseases -- Critical Care -- Preconception Counseling and Prenatal Care -- II. Obstetrics -- Normal Labor and Delivery, Operative Delivery, and Malpresentations -- Fetal Assessment -- Complications of Labor and Delivery -- Gestational Complications -- Preterm Labor and Preterm Premature Rupture of Membranes -- Third-Trimester Bleeding -- Perinatal Infections -- Congenital Anomalies -- Endocrine Disorders of Pregnancy -- Hypertensive Disorders of Pregnancy -- Cardiopulmonary Disorders of Pregnancy -- Renal Disorders, Gastrointestinal Disorders, and Systemic Lupus Erythematosus in Pregnancy -- Hematologic Disorders of Pregnancy -- Alloimmunization -- Surgical Disease and Trauma in Pregnancy -- Postpartum Care and Breast-feeding -- HIV in Pregnancy -- Obstetric Anesthesia -- III. Gynecology -- Anatomy of the Female Pelvis -- Perioperative Care and Complications of Gynecologic Surgery -- Infections of the Genital Tract -- Ectopic Pregnancy -- Chronic Pelvic Pain -- Urogynecology and Reconstructive Pelvic Surgery -- Fertility Control: Contraception, Sterilization, and Abortion -- Domestic Violence and Sexual Assault -- Pediatric Gynecology -- IV. Reproductive Endocrinology and Infertility -- Infertility and Assisted Reproductive Technologies -- Miscarriage and Recurrent Pregnancy Loss -- Uterine Leiomyomas -- Menstrual Disorders: Endometriosis, Dysmenorrhea, and Premenstrual Dysphoric Disorder -- Evaluation of Amenorrhea -- Abnormal Uterine Bleeding -- Hyperandrogenism -- Female Sexual Response and Sexual Dysfunction -- Menopause -- V. Gynecologic Oncology -- Diseases of the Vulva and Vagina -- Cervical Intraepithelial Neoplasia -- Cervical Cancer -- Cancer of the Uterine Corpus -- Ovarian Cancer -- Gestational Trophoblastic Disease -- Chemotherapy and Radiation Therapy -- Palliative Care.

Sex -- Gender and sexuality -- Reproductive messengers -- Testicular function in the adult -- Ovarian function in the adult -- Regulation of gonadal function -- Puberty and the maturation of the hypothalamic-pituitary-gonadal axis -- Actions of steroid hormones in the adult -- Coitus and fertilization -- Implantation and the establishment of the placenta -- Maternal recognition and support of pregnancy -- The fetus and its preparations for birth -- Parturition -- Lactation and maternal behaviour -- Fertility.

Anatomy for the electromyographer / Denise L. Davis and Ernest W. Johnson -- The essentials of the needle EMG exam / Vivek Kadyan, Ernest W. Johnson, and Denise L. Davis -- Basic nerve conduction techniques / Robert J. Weber and Margaret Turk -- Electrophysiology / Jun Kimura -- Instrumentation / Sanjeev D. Nandedkar -- Advanced needle EMG methods / Erik Stålberg -- Quality improvement and reporting in electrodiagnostic medicine / William S. Pease -- Pictorial guide to muscles and surface anatomy / Henry L. Lew and Su-Ju Tsai -- Pictorial guide to nerve conduction techniques / Henry L. Lew and Su-Ju Tsai -- Entrapment neuropathies and other focal neuropathies (including carpel tunnel syndrome) / Lawrence R. Robinson --Evaluation of the patient with suspected peripheral neuropathy / James W. Albers -- Electrodiagnostic approach to patients with suspected radiculopathy / Timothy R. Dillingham -- Evaluation of the patient with suspected myopathy / Albert C. Clairmont, Bakri Elsheikh, and Yousef M. Mohammad -- Neuromuscular complications of critical illness: evaluation of the patient with a suspected critical illness neuromuscular disorder / Daniel M.Clinchot -- Evaluation of the patient with suspected neuromuscular junction disorder / William J. Litchy -- Pediatric considerations in electromyography / Rosalind J. Batley.

"Preface Joint models for longitudinal and time-to-event data have become a valuable tool in the analysis of follow-up data. These models are applicable mainly in two settings: First, when focus is in the survival outcome and we wish to account for the effect of an endogenous time-dependent covariate measured with error, and second, when focus is in the longitudinal outcome and we wish to correct for nonrandom dropout. Due to their capability to provide valid inferences in settings where simpler statistical tools fail to do so, and their wide range of applications, the last 25 years have seen many advances in the joint modeling field. Even though interest and developments in joint models have been widespread, information about them has been equally scattered in articles, presenting recent advances in the field, and in book chapters in a few texts dedicated either to longitudinal or survival data analysis. However, no single monograph or text dedicated to this type of models seems to be available. The purpose in writing this book, therefore, is to provide an overview of the theory and application of joint models for longitudinal and survival data. In the literature two main frameworks have been proposed, namely the random effects joint model that uses latent variables to capture the associations between the two outcomes (Tsiatis and Davidian, 2004), and the marginal structural joint models based on G estimators (Robins et al., 1999, 2000). In this book we focus in the former. Both subfields of joint modeling, i.e., handling of endogenous time-varying covariates and nonrandom dropout, are equally covered and presented in real datasets"--Provided by publisher.

Kinematics and introduction to kinetics -- Kinetics: considering rotatory and translatory -- Materials used in human joints -- General properties of connective tissue -- Human joint design -- Joint function -- Changes with age, disease, injury, immobilization and exercise -- Elements of muscle structure -- Muscle function -- Effects of immobilization, injury, and aging -- Patient case -- General structure and function -- Regional structure and function -- Muscles of the vertebral column -- Effects of aging -- General structure and function -- Rib cage -- Muscles associated with the rib cage -- Coordination and integration of ventilatory motions -- Developmental aspects of structure and function -- Pathological changes in structure and function -- General functions -- Structure -- Function -- Dysfunctions -- Patient case -- Components of the shoulder complex -- Integrated function of the shoulder complex -- Patient case -- Structure: elbow joint (humeroulnar and humeroradial articulations) -- Function: elbow joint (humeroulnar and humeroradial articulations) -- Structure: radioulnar joints (superior and inferior articulations) -- Function: radioulnar joints -- Mobility and stability: elbow complex -- Effects of age and injury -- The wrist complex -- The hand complex -- Prehension -- Functional position of the wrist and hand -- Structure of the hip joint -- Function of the hip joint -- Hip joint forces and muscle function in stance -- Hip joint pathology -- Definitions of motions -- Ankle joint -- The subtalar joint -- Transverse tarsal joint -- Tarsometatarsal joints -- Metatarsophalangeal joints -- Interphalangeal joints -- Plantar arches -- Muscles of the ankle and foot -- Deviations from normal structure and function -- Static and dynamic posture -- Kinetics and kinematics of posture -- Analysis of standing posture -- Analysis of sitting postures -- Analysis of lying postures -- Effects of age, pregnancy,occupation, and recreation on posture -- General features -- Patient case -- Gait initiation -- Kinematics -- Kinetics -- Kinematics and kinetics of the trunk and upper extremities -- Stair and running gaits -- Effects of age, gender, assistive devices, orthoses -- Abnormal gait.

The Mad objects of fin-de-siècle Vienna : journeys, contexts, and dislocations in the exhibition 'Madness and modernity' / Leslie Topp -- Solving riddles : Freud, Vienna, and the historiography of madness / Steven Beller -- Symphonies and psychosis in Mahler's Vienna / Gavin Plumley -- Creating an appropriate social milieu : journeys to health at a sanatorium for nervous disorders / Nicola Imrie -- Travel to the spas : the growth of health tourism in Central Europe 1850-1914 / Jill Steward -- Vienna's most fashionable neurasthenic : Empress Sisi and the cult of size zero / Sabine Wieber -- Peter Altenberg : authoring madness in Vienna circa 1900 / Gemma Blackshaw -- Hell is not interesting, it is terrifying : a reading of the madhouse chapter in Robert Musil's The man without qualities -- Reason dazzled : Klimt, Krakauer, and Eyes of the Medusa / Luke Heighton -- Mapping the sanatorium : Heinrich Obersteiner and the art of psychiatric patients in Oberdbling around 1900 / Anna Lehninger -- The Wuerttemberg Asylum of Schussenried : a psychiatric space and its encounter with literature and culture from the outside / Thomas Mueller and Frank Kuhn.

How science works -- Origin of the theory of evolution: time and change -- Origin of the theory of evolution: social aspects -- Molecular basis of evolutionary theory -- History of the earth and the origin of life -- Origin of species -- Evolution of humans.