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all 953 "I" titles

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  • 2013
    Trantow, Brian M.; Trost, Barry M.; Waymouth, Robert M.; Wender, Paul A.
    The ability of organic chemists to design and synthesize functional molecules has revolutionized the ways in which we can probe biological systems. From catalysts capable of releasing bioactive molecules from bioinactive precursors to oligomers that enable or enhance the uptake of molecules across cell membrane and cell wall barriers, the work described herein emphasizes the power of designing for function. These new tools allow for control over the location of many biologically relevant molecules, including drugs, probes, imaging agents, metabolic modulators, and pesticides, with ramifications for a variety of biochemical, agricultural, and medicinal applications. Chapter 1 reviews the development of selective catalysts designed for use in biological systems. The catalysts have primarily been used for bioconjugations, expanding the classical repertoire of bioconjugation techniques to allow for selective chemistries at many more functional groups than was traditionally possible. Emerging strategies for imaging in biological systems using transition metal catalysis are also reviewed, as are transition metal-based catalytic therapeutics. The synthesis and evaluation of a novel bioorthogonal ruthenium catalyst designed for release of biologically active molecules from inactive precursors is the focus of Chapter 2. Although the challenges associated with using transition metals in biological systems are apparent, creative design ultimately led to the development of a useful bioorthogonal catalyst / substrate pair. This system allows for real-time visualization of transition metal catalysis to generate a biologically active compound that releases photons when it encounters its intracellular enzyme target. Chapters 3 and 4 detail the synthesis and application of molecular transporter scaffolds. Chapter 3 introduces a novel organocatalytic ring-opening oligomerization of guanidinylated cyclic carbonates to access molecular transporter scaffolds in 1 step. This strategy allows for rapid access to molecular transporters of varying lengths. In addition, the synthesis allows for concomitant probe or drug attachment and the carbonate-based backbones of the resulting transporters are biodegradable on a timescale allowing for cellular uptake and intracellular degradation. The ability of molecular transporters to cross not only cell membranes, but also cell walls, is discussed in Chapter 4. These studies focused on the delivery of small molecules and proteins across the algal cell wall and cell membrane barriers using D-octaarginine-based molecular transporters. With this method, it was shown that fluorescein-octaarginine conjugates were able to cross these barriers in a variety of algal species from the class Chlorophyceae, although several species showed no uptake or only cell surface staining. It was also shown in the algal model organism Chlamydomonas reinhardtii that octaarginine-protein conjugates could cross the cell wall and cell membrane barriers to deliver a functional protein to the intracellular algal space.
  • 2013
    Senechal, Marjorie.
    "In the vein of A Beautiful Mind, The Man Who Loved Only Numbers, and Rosalind Franklin: The Dark Lady of DNA, this volume tells the poignant story of the brilliant, colorful, controversial mathematician named Dorothy Wrinch. Drawing on her own personal and professional relationship with Wrinch and archives in the United States, Canada, and England, Marjorie Senechal explores the life and work of this provocative, scintillating mind. Senechal portrays a woman who was learned, restless, imperious, exacting, critical, witty, and kind. A young disciple of Bertrand Russell while at Cambridge, the first women to receive a doctor of science degree from Oxford University, Wrinch's contributions to mathematical physics, philosophy, probability theory, genetics, protein structure, and crystallography were anything but inconsequential. But Wrinch, a complicated and ultimately tragic figure, is remembered today for her much publicized feud with Linus Pauling over the molecular architecture of proteins. Pauling ultimately won that bitter battle. Yet, Senechal reminds us, some of the giants of mid-century science--including Niels Bohr, Irving Langmuir, D'Arcy Thompson, Harold Urey, and David Harker--took Wrinch's side in the feud. What accounts for her vast if now-forgotten influence? What did these renowned thinkers, in such different fields, hope her model might explain? Senechal presents a sympathetic portrait of the life and work of a luminous but tragically flawed character. At the same time, she illuminates the subtler prejudices Wrinch faced as a feisty woman, profound culture clashes between scientific disciplines, ever-changing notions of symmetry and pattern in science, and the puzzling roles of beauty and truth" -- Provided by publisher. "A biography of Dorothy Wrinch" -- Provided by publisher.
  • 2014 Springer
    Gullberg, Donald E.
    "The integrin family is composed of 24 members and approximately ten years ago (2003) we published a book devoted to the nine I domain integrin subunits. In this second edition, I am pleased that most of the original authors have been able to contribute to the updated version. I domain containing integrins include collagen receptors and leukocyte receptors. In 2003 the knockout mouse phenotypes for all of the I domain integrins had not yet been published; they are now, and are summarized and discussed in this edition. Interestingly, a recent 10 integrin mutation in dogs has indicated that collagen-binding integrins in the musculoskeletal system might have much more severe phenotypes in larger animals/humans compared to the mild integrin phenotypes observed in collagen-binding integrin deficient mice. This finding is further discussed in the book. In the cancer field, the microenvironment is taking center stage, and here collagen receptors on fibroblasts are predicted to play important roles in paracrine signaling, in regulating tissue stiffness and matrix remodeling. New technologies, new mouse models in combination with analyses of I integrins in larger animals/humans are thus predicted to increase our knowledge about this group of receptors. With this in mind we look forward to another 10 years of research with I domain integrins."--Publisher's wevsite.
    Also available: Print – 2014
  • 2012
    Edwards, Sarah J. L.; Rees, Geraint; Richmond, Sarah.
    Introduction / Sarah Richmond -- pt. 1. Brain imaging and mindreading : current progress and conceptual questions. The social brain hypothesis : an evolutionary perspective on the neurobiology of social behaviour / Susanne Shultz and R.I.M. Dunbar -- Brain reading / John-Dylan Haynes -- How to read minds / Tim Bayne -- Predicting human behaviour from brain structure / Geraint Rees and Ryota Kanai -- pt. 2. Medical applications of mindreading through brain imaging. When thoughts become actions : neuroimaging in non-responsive patients / Adrian M. Owen -- Where in the brain is pain? : evaluating painful experiences in non-communicative patients / Athena Demertzi and Steven Laureys -- Practicioners' views on neuroimaging : mental health, patient consent, and choice / Emily Borgelt, Daniel Buchman, and Judy Illes -- Brain imaging in clinical psychiatry : why? / Brendan D. Kelly -- Overcoming self-report : possibilities and limitations of brain imaging in psychiatry / David Linden -- pt. 3. Criminal justice and national security : brain imaging in criminal trials and defence. The neurobiology of violence : science and law / Colin Campbell and Nigel Eastman -- Diminished capacity, neuroscience, and just punishment / Stephen J. Morse -- National security, brain imaging, and privacy / Jonathan D. Moreno and Sonya Parashar -- pt. 4. Mindreading as a threat to privacy : evaluating the risks and protecting privacy. Brain imaging and the transparency scenario / Sarah Richmond -- Neuroscience v. privacy? : a democratic perspective / Annabelle Lever -- Regulating brain imaging : questions of privacy, informed consent, and human dignity / Roger Brownsword -- Protecting privacy interests in brain images : the limits of consent / Sarah J.L. Edwards -- Conclusion / Sarah J.L. Edwards and Geraint Rees.
  • Brene Brown.
    PrintStatus: Not Checked OutLane Catalog Record
  • v.1, 1986-
    Preger, Leslie.
    PrintStatus: Not Checked OutLane Catalog Record
  • 2015 Springer
    Justus, Roberto.
    PREVENTION OF WHITE SPOT LESIONS (WSLs): Background: Incidence & Prevalence -- Detection -- Treatment -- Prevention -- Clinical Recommendations. MAINTENANCE OF PERIODONTAL HEALTH AND PREVENTION OF PERIODONTAL DETERIORATION: Extraction vs. non-extraction treatment -- Functional appliances vs. headgear -- Diagnosis and treatment of anterior open bite -- The importance of chin projection -- Stability and Post-treatment retention -- Clinical Recommendations. PREVENTION OF EXTERNAL APICAL ROOT RESORPTION (EARR): Etiologic Factors -- Controversies -- Genetic predisposition -- Evidence -- Root-Sparing Treatment Strategies -- Clinical recommendations.
  • pt. 1. A-K-Pt. 2. L-Z, 2001-
    Wayenborgh, Jean-Paul; Keeler, C. Richard; Mishima, Saiichi.
    PrintStatus: Not Checked OutLane Catalog Record
    Pt. 1. A-K -- Pt. 2. L-Z
  • 2012 Springer
    Rainsford, K. D.
    Ibuprofen is one of the most successful drugs used worldwide for the treatment of mild to moderate pain and various inflammatory conditions, even in a low-dose form for over-the-counter (OTC), non-prescription sale. Over the past 40 years, ibuprofen has been proven to be as safe or safer and just as effective as established non-steroidal anti-inflammatory drugs (NSAIDs) or coxibs. This book reviews the pharmacology, clinical uses and adverse effects of ibuprofen. Its disposition and unique modes of action in relation to clinical effects are discussed as well as various formulations and the impact of food and other variables on its actions and gastro-intestinal safety. The use of combinations of ibuprofen with other drugs (e.g. paracetamol, codeine and caffeine) are critically assessed. There are already some indications of potential therapeutic benefits of the drug combinations in treating certain painful conditions, while still retaining the relative safety benefits of ibuprofen (at least at OTC dosages). The impact of natural products and Chinese Medicines on the safety of ibuprofen is also reviewed. The book is written in a more general style, including explanatory diagrams, for anyone interested in the properties, actions and uses of ibuprofen.
  • Hall, Alan H.
  • 2010- WHO
    Online version includes browsable tabular headings with search capability and instruction manual as well as links to older versions.
  • Ovid, Click on ICD-9-CM tab under Tools
    2004 Natl Cent Health Stat
    v. 1. Diseases, tabular list -- v. 2. Diseases, alphabetic index.
    Also available: Print – v. 1-2, 1991-
  • 2010 Karger
    Elias, Peter M.
    The various manifestations of ichthyoses are classified either by their appearance or their molecular genetics. This volume focuses on generalized, inherited disorders of cornification, which constitute an ever-enlarging group of monogenic diseases caused by a large number of genes that affect a broad array of cellular functions. The authors' overview reflects their unique perspective that the clinical phenotype in the inherited ichthyoses mirrors a 'best attempt' by a metabolically compromised epidermis to maintain a barrier sufficiently impermeable for survival in a desiccating external environment. The basis for threats to survival is illuminated, and the systemic problems, including growth failure, also reflect a compromised barrier. A new consensus classification of these disorders is provided, and the distinguishing clinical features of each disorder are described. Further, the latest molecular genetic information is succinctly reviewed with up-to-date and comprehensive references. Yet, the major emphases of this volume are on disease pathogenesis and on the identification of key ultrastructural features. This publication will prove an invaluable aid to dermatologists, pediatric dermatologists and pediatricians dealing with patients with inherited ichthyoses. In addition, clinical geneticists and dermatopathologists will find it interesting reading.
  • 2007 Ovid
    Marino, Paul L.; Gast, Patricia; Sutin, Kenneth M.
    Also available: Print – 2007
  • 2012 Springer
    Chawla, Rajesh; Todi, Subhash.
    Pt. I. Respiratory system -- pt. II. Cardiovascular system -- pt. III. Nervous system -- pt. IV. Gastrointestinal system -- pt. V. Renal system -- pt. VI. Infectious diseases -- pt. VII. Endocrine and Metabolic system -- pt. VIII. Oncology -- pt. IX. Trauma and burn -- pt. X. Toxicology, envenomation and thermo dysregulation -- pt. XI. Obstetrics -- pt. XII. Perioperative care -- pt. XIII. General issues -- pt. XIV. Pediatrics -- pt. XV. ICU Procedures.
  • 2013 Springer
    Crippen, David.
    Part I: Contrasts in Global Health Care Resource Allocation -- Australia: Where Have We Been? -- Brazil: Where Have We Been? -- Canada: Where Have We Been? -- Germany: Where Have We Been? -- India: Where Have We Been? -- Israel: Where Have We Been? -- Italy: Where Have We Been? -- The Netherlands: Where Have We Been? -- New Zealand: Where Have We Been? -- South Africa: Where Have We Been? -- United Kingdom: Where Have We Been? -- United States-Private Practice: Where Have We Been? -- United States-Academic Medicine: Where Have We Been? -- Australia: Where Are We Going? -- Brazil: Where Are We Going? -- Canada: Where Are We Going? -- Germany: Where Are We Going? -- India: Where Are We Going? -- Italy: Where Are We Going? -- The Netherlands: Where Are We Going? -- New Zealand: Where Are We Going? -- South Africa: Where Are We Going? -- United Kingdom: Where Are We Going? -- United States-Private Practice: Where Are We Going? -- United States-Academic Medicine: Where Are We Going? -- Re fl ections on the Demand for Critical Care in the Global Medical Village -- First Critique of Buchman and Chalfin's Analysis -- Second Critique of Buchman and Chalfin's Analysis -- Third Critique of Buchman and Chalfin's Analysis -- Fourth Critique of Buchman and Chalfin's Analysis -- Part II: The Fair and Equitable Health Care Act -- The Fair and Equitable Health Care Act -- First Critique of the Fair and Equitable Health Care Act -- Fixing the Foundation of Critical Care at the End-Stage of Life: Second Critique of the Fair and Equitable Health Care Act -- Third Critique of the Fair and Equitable Health Care Act -- Part III: Legal and Nursing Viewpoints -- Medical Judgment Versus Capitulation -- Nursing Aspects of Inappropriate Patient Care -- Part IV: Conclusions -- Where Is "Universal" Health Care Headed in the Global Village? -- The New Shape of Intensive Care In the USA -- Health Care in the Year 2050.
  • 2007/2008
    Jarvis, Lesley Ann.
    PrintStatus: Not Checked OutLane Catalog Record
  • 2010
    Piccione, Emily C.; Kuo, Calvin Jay; Mitchell, Beverly S.; Sweet-Cordero, E. Alejandro; Wong, Albert J.
    The epidermal growth factor receptor (EGFR) is essential to multiple physiologic and neoplastic processes via signaling by its tyrosine kinase domain and subsequent activation of transcription factors. We identified a novel splice variant of the EGFR called mini-LEEK (mLEEK) which represents a deletion of exons 2-22 but maintains the open reading frame and generates a novel glycine codon at the junction. This variant deletes the extracytoplasmic domain, transmembrane region, and most of the tyrosine kinase domain of the EGFR. mLEEK is localized to the nucleus in most cells and since it contains a previously characterized strong transactivation domain, we hypothesized that mLEEK functions to regulate transcription. Microarray studies revealed upregulation of several molecular chaperone proteins, including GRP78 (also known as BiP) and GRP94, in response to mLEEK expression. Overexpression of mLEEK resulted in increased transcription from GRP78 and GRP94 luciferase reporter plasmids as well as an increase in endogenous GRP78 and GRP94 protein levels, suggesting a direct effect on transcription. Furthermore, mLEEK utilizes the cis-regulatory ER stress response element (ERSE) found in both the GRP78 and GRP94 promoters to activate transcription as mutation of the ERSE elements in the GRP78 promoter abolishes the activation of transcription by mLEEK. Chromatin immunoprecipitation experiments demonstrate that mLEEK physically interacts in a complex with the ERSE-containing region of the GRP78 promoter. Additionally, mLEEK co-precipitates with ATF6, a transcription factor known to be part of the ERSE-mediated activation of chaperones. Molecular chaperone transcription is induced as a downstream effector of the unfolded protein response (UPR). The UPR is a mechanism that increases the cellular capacity for protein folding. Cellular demands for protein folding increase upon physiological conditions that create endoplasmic reticulum (ER) stress. Interestingly, mLEEK specifically upregulates molecular chaperones required for the UPR and does not activate other arms of the UPR. Splicing of XBP1 precursor mRNA, which is uniquely triggered upon ER stress, was reduced in cells overexpressing mLEEK. Another molecular readout for UPR induction is the activation of CHOP transcription. Cells overexpressing mLEEK demonstrated reduced activation of CHOP transcription in the presence of ER stress inducing agents. Moreover, knockdown of mLEEK results in enhanced sensitivity to ER stress. Collectively, these data suggest that expression of mLEEK and the subsequent upregulation molecular chaperones primes cells to accommodate the increased need for protein folding upon ER stress and prevents induction of the UPR. mLEEK is also essential for cell viability, as mLEEK knockdown lead to reduced viability and increased activation of caspases. We found that mLEEK is present at the RNA and protein level in a high percentage of tumors relative to normal tissue. Preliminary data suggest that mLEEK expression does not lead to transformation of NIH3T3 cells. The potential contribution of mLEEK to tumorigenesis will be revisited in the future using knockdown strategies that were subsequently developed. Other preliminary data have shown that mLEEK is secreted into the media and taken up by neighboring cells, leading to increased GRP94 transcription in recipient cells. Collectively, our work describes the discovery and characterization of a novel EGFR variant. These findings reveal an unexpected function for an EGFR variant and represent a new mechanism for the upregulation of molecular chaperones required for the UPR that could be exploited for therapeutic purposes. Our findings also suggest a potential role for mLEEK in cancer and a novel method of cell communication mediated by a secreted protein. These possibilities await future studies.
  • 2005/2006
    Hsieh, Christine Linda.
    PrintStatus: Not Checked OutLane Catalog Record
  • 2012
    Dowlatshahi, Dara Patrick; Kopito, Ron; Nachury, Maxence; Nelson, W. J.; Wandless, Thomas.
    The covalent attachment of ubiquitin (Ub), a 76-amino-acid protein, to another protein is a highly occurring and conserved post-translational modification. Ub functions in a plethora of diverse signaling pathways including proteasomal degradation, endocytosis and trafficking of membrane receptors and DNA repair when conjugated to substrate proteins. Ub is unique in that it can also be conjugated to itself to create an assortment of polyubiquitin chains, through either its amino terminus or any of its seven internal lysines, where a large part of its diverse signaling is ascribed to these polyubiquitin chains. Previous work has identified proteins, which specifically recognize these different types of Ub linkages to contain domains or motifs termed Ub binding domains (UBDs). Studies on the various and diverse roles of Ub signaling along with its own diversity of conjugates present on substrates and their recognition by UBDs have uncovered the existence of a Ub syntax or code. The main goal of the work entailed in this thesis was to contribute to decryption of this code by identifying new linkage specific polyubiquitin binding proteins and characterizing their function and mechanism of polyubiquitin recognition. We developed and used a K63 linkage specific polyubiquitin affinity reagent in conjunction with shotgun LC-MS/MS to identify novel polyubiquitin binding proteins. We found that the majority of polyubiquitin dependent identified proteins were previously known Ub binders as well as a few previously unidentified Ub interacting proteins, demonstrating this as a valid approach for the identification of polyubiquitin binding proteins. One such previously unidentified protein we identified was ALIX, a a component of the Endosomal Sorting Complex Required for Transport (ESCRT) machinery known to be involved in Human Immunodeficiency Virus (HIV) budding. We characterized ALIX and found that it binds directly and selectively to K63-linked polyubiquitin via two potential Ub binding sites on a single [alpha]-helical surface within a coiled-coil region, where mutation of these sites impaired retroviral release. Our study demonstrates ALIX as the first example of a K63 chain specific polyubiquitin receptor in the endosomal sorting pathway that supplies evidence for a functional link between K63 polyubiquitin binding and ESCRT function, specifically in retrovirus budding. In summary the findings in our study contribute to the understanding of the role of K63-linked polyubiquitin in the ESCRT pathway. Our work also demonstrates the power of using unbiased affinity capture and tandem mass spectrometry to identify polyubiquitin receptor proteins to further decryption of the Ub code.
  • 2010
    Biller, Steven James; Burkholder, William; Grossman, Arthur R.; Hanawalt, Philip C.; Spormann, Alfred M.
    Dividing cells must ensure that their DNA is accurately replicated and that both copies of the chromosome are faithfully segregated into the new daughter cells before cell division completes. Here, I describe the identification and characterization of mechanisms that contribute to the coordination of cell division with DNA replication in the Gram-positive soil bacterium Bacillus subtilis. I developed a genetic screen to isolate mutations that increase the frequency with which B. subtilis cells erroneously divide over their chromosome when DNA replication is perturbed. Seventeen mutations were isolated in genes involved in a range of cellular processes including DNA repair, chromosome organization, cell wall structure, and central carbon metabolism. Six mutations affecting cell cycle coordination in B. subtilis were characterized, including detailed studies of the mechanism by which the DNA translocase SftA promotes chromosome separation at nascent division septa. I also investigated the role of YycJ, a putative metallo-beta-lactamase, in regulating cell division.
  • 2009 Springer
    Gil-Perotín, Sara; Álvarez-Buylla, Arturo; García-Verdugo, José Manuel.
    Adult neurogenesis has been questioned for many years. In the early 1900s, a dogma was established that denied new neuron formation in the adult brain. Adult neural stem cells are undifferentiated cells that are present in the adult brain and are capable of dividing and differentiating into glia and new neurons.
  • 2009
    Gontang, Allison Camille.
    PrintStatus: Not Checked OutLane Catalog Record
  • 2011
    Firestone, Ari Joseph; Chen, James K.; Meyer, Tobias; Nelson, W. J.; Scott, Matthew P.
    Proper activation of Hh signaling is a critical mediator of metazoan development whereas aberrant activation, in post-embryonic tissues, is associated with initiation or progression of numerous common tumors. In chapter 1 of this dissertation I review the history, development, and status of extant small-molecule Hh inhibitors. I discuss limitations in the current approaches utilized in the discovery of these compounds, and the successes and challenges associated with tackling this pathway with targeted therapeutics. In chapter 2, I detail our progress using high-throughput screening to discover new small-molecule inhibitors of Hh signaling by specifically targeting elements of the pathway downstream of the transmembrane protein Smoothened (Smo), the target of the vast majority of existing inhibitors. These efforts resulted in the identification and preliminary characterization of four small molecules, each of which displays a distinct and novel combination of effects on various downstream signaling processes including formation of the primary cilia, the Hh-dependent regulation of Gli proteolytic-processing, and activation of Gli transcription factors. These compounds therefore represent valuable probes for further dissection of mechanisms of Hh signaling downstream of Smo and possible leads in the development of mechanistically novel Hh targeted chemotherapeutics. The third chapter continues with an in depth study of the Hh antagonist capable of preventing formation of primary cilia. We name this compound and its structurally and functionally related congeners ciliobrevins. We observe that acute treatment of cells with ciliobrevins leads to an accumulation of proteins in the distal tips of primary cilia, a phenotype that is consistent with inhibition of dynein-dependent retrograde protein trafficking. Ciliobrevin treatment also causes defects in mitotic spindle formation and the subcellular movement of organelles that are reminiscent of those observed under dynein loss of function conditions. Finally we show that ciliobrevins inhibit dynein-dependent microtubule gliding and dynein ATPase activities in vitro, demonstrating that this motor protein represents the critical physiological target of these small-molecule Hh inhibtors. This dissertation is concluded by a broader review of the use and development of small-molecules to control additional developmental signaling pathways and processes such as differentiation and self-renewal. Alterations in fate choice are central to a plethora of human diseases and chemically manipulating these will be a critical aspect in the advancement of medical technology from the treatment of tumors, to the advent of regenerative therapies.
  • 2006
    Bay, Joseph Michael.
    PrintStatus: Not Checked OutLane Catalog Record
  • 2006
    Cooper, Sara Joan.
    PrintStatus: Not Checked OutLane Catalog Record
  • 2005 ScienceDirect
    Chowdhury, Swapan K.
  • 2006
    Ray, Emily Elizabeth.
    PrintStatus: Not Checked OutLane Catalog Record
  • 2003 Wiley
    Westwick, David T.; Kearney, Robert E.
    ch. 1. Introduction, p. 1-12 -- ch. 2. Background, p. 13-38 -- ch. 3. Models of Linear Systems, p. 39-56 -- ch. 4. Models of Nonlinear Systems, p. 57-101 -- ch. 5. Identification of Linear Systems, p. 103-123 -- ch. 6. Correlation-Based Methods, p. 125-167 -- ch. 7. Explicit Least-Squares Methods, p. 169-206 -- ch. 8. Iterative Least-Squares Methods, p. 207-250.
  • 2003 ScienceDirect
    Ortner, Donald J.
  • 2011
    Riordan, Daniel Patrick; Brown, Patrick O.; Fire, Andrew Z.; Herschlag, Daniel; Sidow, Arend; Stearns, Tim.
    The unique post-transcriptional behavior of each mRNA is thought to be largely determined by features present in its molecular sequence, representing a type of RNA regulatory code. However, the details by which distinct regulatory outcomes are programmed into the sequences of different transcripts are mostly unknown. We set out to identify features of yeast mRNAs that influence their post-transcriptional fates. Using bioinformatic and in vitro selection approaches, we characterized several RNA recognition elements involved in mediating specific interactions with individual yeast RNA-binding proteins (RBPs). Most of the RNA elements we uncovered were associated with significant mRNA expression changes and were phylogenetically conserved in related yeasts, providing insights into the function and evolution of the corresponding interactions. We also analyzed RNA-protein interaction sites for the yeast Puf3 RBP by high-throughput sequencing under different growth conditions. These results provided high-resolution experimental evidence for Puf3 binding at consensus RNA elements in the transcriptome, and enabled detailed comparisons of individual interaction sites. Finally, we developed complementary methods for transcriptome-wide mapping of potential sites of RNA 2'-O-methylation. Application of these methods to the yeast transcriptome successfully recovered known sites of RNA modification and suggested that ribose methylation of functionally-related transcripts may occur and influence the regulation of endogenous yeast mRNAs. Overall, these results contribute to understanding of how RNA sequence features help to specify global differences in gene expression characteristics.
  • 2007
    MacFarlane, Ryan Cousteau.
    PrintStatus: Not Checked OutLane Catalog Record
  • 2009 Springer
    Brock, Stephen E.; Hansen, Robin L.; Jimerson, Shane R.
    ADHD is the most commonly diagnosed childhood behavioral disorder. Moreover, many students receiving special education assistance are reported to have ADHD. This book offers guidance on conducting psycho educational assessments of children with ADHD. It is suitable for school psychologists, and mental health professionals.
  • 2009 Springer
    Christo, Catherine; Brock, Stephen E.; Davis, John M.
    "As many as one in four children experiences problems with reading. Dyslexia, the most common learning disability leads to well-documented negative effects on school and, ultimately, adult success. Therefore, it is critical that school professionals provide early and effective assessment and intervention. This volume equips practitioners with in-depth understanding of the disorder and a wealth of practical information for meeting student needs." "As the duties of school psychologists and related education professionals become more complex, recognizing and providing services for students with learning disorders has become progressively more demanding. Identifying, Assessing, and Treating Dyslexia at School offers practitioners an accessible and easy-to-read reference that they will use for years to come."--BOOK JACKET.
  • 2008
    Meissner, Geoffrey Wilson.
    PrintStatus: Not Checked OutLane Catalog Record
  • 2008
    Hillenmeyer, Maureen Elizabeth.
    PrintStatus: Not Checked OutLane Catalog Record
  • 2014 Springer
    Meyer, Keith C.; Nathan, Steven D.
    Idiopathic Pulmonary Fibrosis: A Comprehensive Clinical Guide delivers a concise review of our current understanding of disease pathogenesis and provides current evidence in the medical literature regarding its diagnosis and management. Each chapter includes key points and a summary aiming to update clinicians about various issues concerning the diagnosis and management of IPF. In addition to outlining the current state of knowledge, each chapter also provides a summary of ongoing research and identifies the needs for future research in the field. Idiopathic Pulmonary Fibrosis: A Comprehensive Clinical Guide is an important new text that provides its readers with a better understanding of the pathobiology and natural history of IPF as it continues to evolve.
  • 2010 Thieme eNeurosurgery
    Betz, Randal R.; Dickson, Robert A.; Harms, Jürgen; Newton, Peter O.; O'Brien, Michael F.; Shufflebarger, Harry L.
    Based on over a decade of research and observation conducted by the members of the Harms Study Group and other spinal deformity experts from around the world, this must-have clinical reference provides focused coverage of the most current evaluation and treatment guidelines for idiopathic scoliosis. It draws on case studies to guide readers through specific surgical and nonoperative approaches to the multiple types of adolescent idiopathic spinal deformity, including practical information on the rationale for each approach, techniques, and results. Chapters on key treatment decisions, such as the selection of fusion levels, that teach readers how to critically address clinical questions. More than 600 high-quality illustrations, including numerous full-color clinical photographs, detailed line drawings, and complementary high-resolution radiographs. This state-of-the-art text is ideal for orthopaedic surgeons, neurosurgeons, and spine fellows, and is an invaluable companion for any practitioner involved in the surgical and nonsurgical care of patients with spinal deformity.
  • 2006 HighWire
    Fernʹandez-Avilʹes, Francisco.
  • 2005 HighWire
    Fernández-Avilés, Francisco.
    Also available: Print – 2005
  • 2007 HighWire
    Fernʹandez-Avilʹes, Francisco.
  • 2007 Karger
    Tomino, Yasuhiko.
    Also available: Print – 2007
  • 2015 Springer
    Curotto de Lafaille, Maria A.; Lafaille, Juan José.
    Biology of IgE production: IgE cell differentiation and the memory of IgE responses / Jin-Shu He, Sriram Narayanan, Sharrada Subramaniam, Wen Qi Ho, Juan J. Lafaille and Maria A. Curotto de Lafaille -- Molecular mechanisms of IgE class switch recombination / Pei Tong and Duane R. Wesemann -- Anti-IgE therapy: clinical utility and mechanistic insights / Stephanie L. Logsdon and Hans C. Oettgen -- New insights on the signaling and function of the high-affinity receptor for IgE / Ryo Suzuki, Jörg Scheffel and Juan Rivera -- Helminth-induced IgE and protection against allergic disorders / Firdaus Hamid, Abena S. Amoah, Ronald van Ree and Maria Yazdanbakhsh -- IgE immunotherapy against cancer / Lai Sum Leoh, Tracy R. Daniels-Wells and Manuel L. Penichet -- Index.
  • 2013
    Kim, Beomkyu; Jardetzky, Theodore; Jones, Patricia; Puglisi, Joseph D.; Weis, William I.
    IgE antibodies interact with the high affinity IgE Fc receptor (Fc [epsilon] RI) expressed on mast cells and basophils, and the low affinity IgE Fc receptor (CD23) on B cells. These interactions are directly involved in triggering the allergen-specific activation of inflammatory responses. The IgE-Fc region, comprising the C-terminal domains of the IgE heavy chain, binds Fc [epsilon] RI and the crystal structures of the human IgE-Fc alone and IgE-Fc complexes exhibited IgE-Fc conformational flexibility. In addition, the crystal structure of IgE-Fc bound to CD23 indicated a preference of CD23 for a closed conformation of the IgE-Fc incompatible with Fc [epsilon] RI binding. These observations suggested the importance of IgE conformational dynamics for its receptor binding mechanism and the potential to identify non-classical or allosteric inhibitors for IgE-receptor interactions. To investigate IgE dynamics and its role in receptor binding and inhibition, I have employed 5 experimental approaches: 1) IgE-Fc mutants trapped by an engineered disulfide bond, blocking Fc [epsilon] RI but not IgE inhibitor binding, 2) a fluorescence assay for IgE-Fc:Fc [epsilon] RI binding and inhibition that can distinguish IgE-inhibitors based on their proximity to the Fc [epsilon] RI binding site, 3) the determination of the E2_79 crystal structure showing that the IgE inhibitor E2_79 binds IgE-Fc outside the Fc [epsilon] RI-binding site and acts through a facilitated dissociation mechanism to block receptor binding, 4) the development of a TR-FRET assay suitable for high-throughput screening for small molecule inhibitors of IgE-receptor binding, and 5) a single-molecule FRET approach to characterize the conformational states of the IgE-Fc3-4 and observe changes upon Fc [epsilon] RI, CD23, and E2_79. These experiments revealed different conformational requirements for IgE binding, identified a disruptive inhibitor that actively dissociates preformed receptor complexes, and provided direct observation of receptor binding-induced IgE-Fc conformational changes. This work provides a new perspective on the role of IgE dynamics in receptor binding and inhibition, and makes possible the development of new disruptive inhibitors for IgE-receptor binding acting through non-classical or allosteric mechanisms.
  • 2005 Karger
    Cianfarani, Stefano; Clemmons, David R.; Savage, M. O.
    The IGF system: new developments relevant to pediatric practice / Rosenfeld, R.G. -- Clinical relevance of systemic and local IGF-I / Yakar, S. ... [et al.] -- Cartilage disorders: potential therapeutic use of mesenchymal stem cells / Spagnoli, A., Longobardi, L., O'Rear, L. -- Treatment in animal models / Guan, J. ... [et al.] -- Insulin-like growth factor-I and risk of type 2 diabetes and coronary heart disease: molecular epidemiology / Sandhu, M.S. -- Quantitative measurement of IGF-I and its use in diagnosing and monitoring treatment of disorders of growth hormone secretion / Clemmons, D.R. -- IGF-I and IGFBP-3 assessment in the management of childhood onset growth hormone deficiency / Cianfarani, S., Liguori, A., Germani, D. -- IGFs and IGFBPs in clinical management of adult growth hormone deficiency / Aimaretti, G. ... [et al.] -- Monitoring of insulin-like growth factors during growth hormone treatment: adulthood growth hormone deficiency / Monson, J.P. -- IGFs and IGFBPs in clinical management: GH insensitivity / Savage, M.O. ... [et al.] -- Childhood and adol[e]scent diabetes / Dunger, D.B., Regan, F.M., Acerini, C.L. -- Insulin resistance and type 2 diabetes mellitus: is there a therapeutic role for IGF-1? / Moses, A.C. -- Insulin-like growth factors in the treatment of neurological disease / Leinninger, G.M., Feldman, E.L. -- Insulin-like growth factor system in amyotrophic lateral sclerosis / Wilczak, N., De Keyser, J.
  • 2010 Springer
    Christen, Yves; Clemmons, David R.; Robinson, Iain C. A. F.
  • 2014 Springer
    Kawa, Shigeyuki; Kawano, Mitsuhiro; Okazaki, Kazuichi; Stone, John H.; Umehara, Hisanori.
    IgG4-related disease is a new systemic disease that has only recently been identified and characterized. However, most clinical practitioners are not yet familiar with it and thus are likely to misdiagnose it. The purpose of this book is to raise awareness of this disease and its diagnostic pitfalls. A wealth of radiological and histopathological images helps clinicians to understand its characteristics in various organs as well as their clinical and basic medical backgrounds. All of the authors are experts who have published numerous important papers in the field. This book will be useful to physicians in various disciplines such as gastroenterology, rheumatology, ophthalmology, otolaryngology, urology, hematology, and respiratory medicine, not only as a textbook but as an authoritative and comprehensive reference work as well.
  • 2010 Springer
    Gaist, Paul A.
  • 2013 Springer
    Di Padova, Franco; Quesniaux, Valérie; Ryffel, Bernhard.
    The knowledge of Th17 cells and other cell populations which secrete IL-17A, and/or IL-22 has expanded tremendously since the publication of the first edition "Th17 Cells: Role in Inflammation and Autoimmune Disease" in 2008. The present volume has been completely revised with the addition of new chapters on the IL-17 receptor family and signaling, and an in-depth review of IL-22 and innate lymphoid cells. The differentiation of naïve T cells into regulatory T cells and Th17 cells as well as the plasticity of Th17 cells is discussed.
    Also available: Print – 2013
  • 2012 Springer
    Trecca, Antonello.
    Ileoscopy has proven to be very useful for the diagnosis of celiac, inflammatory, and infectious diseases of the small intestine. This endoscopic procedure is one of the most technically challenging steps of diagnostic colonoscopy but it also represents the best documented proof of a complete examination. This book covers all aspects of the endoscopic exploration of the terminal ileum, from the technique itself to the clinical diagnosis and management of the main pathologies that occur in this region of the digestive tract. A wide selection of magnified and non-magnified diagnostic images accompanies the text. Intended as an update on the imaging and management of ileal disease, the book provides an invaluable tool for improving the endoscopist's technique and for enhancing the clinician's knowledge of small-bowel diseases.
  • 2011
    Layton, Blythe Anderson; Boehm, Alexandria; Criddle, Craig; Francis, Christopher.
    This work takes a multi-disciplinary approach to ocean and human health research by investigating illness/climate relationships through time series modeling and evaluating two microbial source tracking tools for human specificity. In each case the subject of the work is the California coast. In the first project, associations were characterized and modeled between four gastrointestinal illnesses and a number of climate factors across an eleven-year time series of data from Orange County, CA. The results suggest that incidence of gastrointestinal illness in Orange County may increase as a result of rising temperatures due to global climate change. The second project evaluated the use of Enterococcus species differentiation as a microbial source tracking tool in California recreational waters. The results indicate that no single Enterococcus species is a reliable indicator of the host fecal source; however, Enterococcus species composite 'fingerprints' may offer auxiliary evidence for bacterial source identification. The third project evaluated the distribution of the enterococcal surface protein (esp) gene in E. faecium in the Pacific coast environment as well as the distribution and diversity of the gene in Northern California animal hosts. The gene was found to be widespread in non-human animal feces and DNA sequence analysis revealed that esp gene sequences were not divergent between hosts. Overall, the work presented here indicates that gastrointestinal illness rates in California may increase over time, and that Enterococcus-based microbial source tracking methods are insufficient tools to assess risk from recreational water exposure.
  • 2010
    Tsai, Hsing-Chen; Deisseroth, Karl; Huguenard, John R.; Malenka, Robert C.; Palmer, Theo D.
    This thesis examines a neural substrate (i.e. dopaminergic signaling) of reward, by integrating techniques designed to manipulate and quantify changes in behavior, neural activity, and neurotransmitter release in freely-moving animals. Dopaminergic signaling is essential to the brain's reward system. The majority of dopaminergic neurons reside in the ventral tegmental area (VTA) and project to diverse brain regions including the nucleus accumbens (NAc), one of the major integrative hubs of reward signals. Dopaminergic neurons are known to fire in two distinct modes (phasic, > 15Hz; tonic, < 10Hz) under different behavioral conditions. Both firing modes are known to be involved in multiple reward-related behaviors in normal and neuropsychiatric conditions. However, the casual role of dopaminergic neuron activity in reward-related behaviors remains unclear, largely due to a lack of technologies to selectively control dopaminergic neuron signaling in freely-moving animals during reward-related behavioral tasks. To solve this problem, we first developed a set of optogenetic technologies to selectively control dopaminergic neuron activity in vivo. By targeting a light-sensitive microbial opsin, channelrhodopsin-2 (ChR2), to the VTA dopaminergic neurons we were able to modulate dopaminergic neuron activity in freely-moving mice during behavioral tasks. We accomplished this using a thin optical fiber to deliver precisely-timed trains of light flashes directly into the VTA. We found that phasic and not tonic firing evoked by light in dopaminergic neurons is sufficient to mediate a strong conditioned place preference in rodents in the absence of other reward. Similarly, phasic dopaminergic neuron firing reinforces the lever-pressing behavior during an operant conditioning task. Phasic firing also induced substantial transient dopamine release in NAcc, as measured by fast scan cyclic Voltammetry (FSCV). Together, our behavioral and electrochemical data demonstrate a causal role of phasic dopaminergic neuron firing in behavioral conditioning. The integration of cell-specific targeting techniques with electrophysiological, behavioral, and biochemical readout methods proves to be a powerful approach to studying the role of dopaminergic signaling in the brain reward system and is likely to prove effective in the study of neuropsychiatric disorders such as depression and addiction.
  • 2007 Springer
    Rifkin, Erik; Bouwer, Edward; Sheff, Bob.
  • 2012 Springer
    Nomori, Hiroaki; Okada, Morihito.
    "Advances in computed tomography have made it possible to detect small lung cancers, which has changed lung cancer surgery from lobectomy to a lesser lobar resection such as a segmentectomy or wedge resection. Although wedge resection is a simple procedure, it has a higher risk of hilar lymph node or surgical margin recurrence than does a lobectomy. On the other hand, segmentectomy is a well-known curative surgery for small lung cancers. It is difficult to perform accurately, however, because of its anatomical complexity, which makes surgeons hesitant to use it. Illustrated Anatomical Segmentectomy for Lung Cancer provides readers a detailed explanation of segmentectomy with numerous easy-to-understand color illustrations showing the precise segmental anatomies for each pattern of the procedure. To better illustrate an accurate anatomical segmentectomy, the text shows details of anatomy during the procedure. Up to 25 patterns can be involved, each of which is shown in approximately 10 illustrations."--publisher's website
  • 2005 CRCnetBASE
    Koren, Herman.
    Also available: Print – 2005
  • 2006
    Mallory, Susan B.
    PrintStatus: Not Checked OutLane Catalog Record
  • 2009 CRCnetBASE
    Cruse, Julius M.; Lewis, R. E.
    Also available: Print – 2009
  • Virtual Hospital
    Afifi, Adel K.; Bergman, Ronald A.; Miyauchi, Ryosuke.
  • 2014 Springer
    Al-Salem, Ahmed H.
    Written in a simple point by point style for ease of use, this volume covers all aspects of pediatric surgery with emphasis on important points for diagnosis and management. Each chapter covers a topic with emphasis on the most common conditions in neonatal and general pediatric surgery. The text is well illustrated with clinical, operative, radiological, and histopathological color figures and illustrations. The book also presents some of the rare conditions encountered in pediatric surgery, as well as common pediatric urology conditions. An Illustrated Guide to Pediatric Surgery is a useful reference to pediatric surgeons, specialists, fellows and residents, as well as general surgeons, pediatricians, neonatologists, medical students and interns interested in pediatric surgery.
  • 2011 Thieme Book
    Reichl, Franz-Xaver; Ritter, Leonard.
    This book serves as a hands-on guide to various poison treatments and offers supplemental public health information. Each two-page unit features concise text on the left complemented by full-color illustrations on the opposing page. The expert author distinguishes harmful toxic substances and catalogues their specific effects on the human body, plants, animals, and the surrounding environment. The handbook also addresses other topics, including biological warfare, modern toxicological methods, and threshold values. Features include: succinct, user-friendly organization so readers can navigate the content with ease; over 600 detailed images and diagrams arranged on 150 full-color plates illustrate exposures and toxicological effects on humans, plants, and animals; well-researched, objective risk analysis on toxic exposures accompanied by relevant images; extensive glossary of key toxicological terms that provide readers with the accurate information they need to avoid dangerous confusion.
  • 2009 ClinicalKey
    Evans, Ronald C.
    "Used as a definitive assessment resource by orthopedic practitioners and students alike, this text continues to be known and trusted for both its depth of coverage and its accessible, accurate information. The third edition retains practical features such as gamuts, clinical pearls, and cross-reference tables, while adding more than 500 new illustrations, the majority in full color."--Jacket.
  • 2006
    Orazi, Attilio; Arber, Daniel A.; O'Malley, Dennis P.
    PrintStatus: Not Checked OutLane Catalog Record
    The normal bone marrow and an approach to bone marrow evaluation of neoplastic and proliferative process -- Granulomatous and histiocytic disorders -- The aplasias -- The hyperplasias -- Other non-neoplastic marrow changes -- Myelodysplastic syndromes -- Acute leukemia -- Chronic myeloproliferative disorders and systemic mastocytosis -- Myelodysplastic/myeloproliferative disorders -- Chronic lymphoproliferative disorders and malignant lymphoma -- Immunosecretory disorders/plasma cell disorders and lymphoplasmacytic lymphoma -- Metastatic lesions -- Post-therapy bone marrow changes.
  • 2012 ClinicalKey
    Clayden, Graham; Lissauer, Tom.
    Child in society -- History and examination -- Normal child development, hearing and vision -- Developmental problems and the child with special needs -- Care of the sick child -- Paediatric emergencies -- Accidents, poisoning and child protection -- Genetics -- Perinatal medicine -- Neonatal medicine -- Growth and puberty -- Nutrition -- Gastroenterology -- Infection and immunity -- Allergy -- Respiratory disorders -- Cardiac disorders -- Kidney and urinary tract disorders -- Genitalia -- Liver disorders -- Malignant disease -- Haematological disorders -- Emotions and behaviour -- Skin disorders -- Endocrine and metabolic disorders -- Musculoskeletal disorders -- Neurological disorders -- Adolescent medicine.
  • 2010 Springer
    Chen, Herbert.
    I. Endocrine surgery -- II. Breast surgery -- III. Esophageal and gastric surgery -- IV. Small bowel and appendix surgery -- V. Colorectal surgery -- VI. Anorectal surgery -- VII. Hernia surgery -- VIII. Hepatobiliary surgery -- IX. Pancreatic surgery.
  • 2011
    Red Eagle, A.; Barsh, Gregory Stefan; Brunet, Anne; Chawla, Ajay; Vollrath, Douglas E.
    Obesity is recognized as a state of chronic inflammation associated with the development of insulin resistance and type 2 diabetes. Macrophages play an important role in this process by homing to adipose tissue and perpetuating this inflammatory state. In the setting of obesity, there is a recruitment of "classically activated, " or inflammatory macrophages. However, macrophages are present throughout the body in important metabolic organs such as adipose tissue and the liver before the development of obesity. Resident tissue macrophages in these metabolic organs reside in a state of "alternative activation, " an anti-inflammatory activation state driven by the Interleukin-4/STAT6 signaling pathway. Alternatively activated macrophages activated by the IL-4/STAT6 axis rely on fatty acid metabolism to drive their metabolic demand. Peroxisome proliferatoractivated receptors, or PPARs are fatty acid sensors that drive metabolic processes in a variety of tissues. In the first two chapters, we demonstrate that PPAR[lowercase Gamma] and PPAR[lowercase Delta] are required for alternative macrophage activation in adipose tissue macrophages and Kupffer cells of the liver respectively. Absence of either transcription factor in macrophages leads to the development of obesity induced insulin resistance. Macrophage co-culture experiments with adipocytes or hepatocytes demonstrate the important metabolic impact that PPAR[lowercase Gamma] and PPAR[lowercase Delta] play in macrophages from these two tissues. The IL-4/STAT6 axis also plays an important role in metabolic tissues as well as tissue macrophages. In the final chapter, we demonstrate that IL-4 is capable of activating STAT6 is the liver. We demonstrate that IL-4 acts through STAT6 to repress the transcriptional activity of PPAR[Alpha] in the liver and improves insulin sensitivity in the setting of obesity. Induction of an inflammatory response producing IL-4 also leads to an improvement in insulin sensitivity, indicating that not all inflammation is deleterious to insulin signaling. Together, these results demonstrate that the IL-4/STAT6 signaling pathway plays an important role in both the immune system and metabolic tissues to improve insulin sensitivity.
  • 2014 CRCnetBASE
    Ng, Y. K. Eddie.
    "The human eye is a complex and important organ that works similarly to the conventional camera. Many advanced image-processing algorithms have been proposed to analyze the subtle changes in the eye to diagnose eye abnormalities efficiently. Digital fundus images have been used efficiently for the diagnosis of diabetes retinopathy and glaucoma. Infrared imaging provides a temperature profile that depicts changes in the vascular tissues, which helps to study the ocular surface temperature (OST) and ocular diseases like dry eye and cataracts. This book covers the detection of diabetes retinopathy, glaucoma, and anterior segment eye abnormalities; instruments for the detection of glaucoma; and the development of a human eye model using computational fluid dynamics and heat transfer principles to predict inner temperatures of the eye from its surface temperature. Ultrasound biomicroscopy (UBM) is one of the imaging systems that allow visualization of the anatomy and pathology of the anterior segment. It is particularly beneficial in evaluating regions of the eye behind the iris such as the ciliary body, lens zonular attachment, and lens periphery, which are obscured in other anterior scanning systems. In glaucoma imaging, UBM plays a significant role in objective assessment of peripheral anterior chamber angle morphology, which is useful in angle closure glaucoma diagnosis and management. Chapter 1 presents a UBM system for anterior chamber angle imaging. Chapter 2 describes both the formal design and development of an automated anterior segment eye disease classification system. The proposed system can be used for early disease diagnosis and treatment management"-- Provided by publisher.
  • 2006
    Maglogiannis, Ilias G.; Karpouzis, Kostas; Wallace, Manolis.
    E-health is closely related with networks and telecommunications when dealing with applications of collecting or transferring medical data from distant locations for performing remote medical collaborations and diagnosis. In this book we provide an overview of the fields of image and signal processing for networked and distributed e-health applications and their supporting technologies. The book is structured in 10 chapters, starting the discussion from the lower end, that of acquisition and processing of biosignals and medical images and ending in complex virtual reality systems and techniques providing more intuitive interaction in a networked medical environment. The book also discusses networked clinical decision support systems and corresponding medical standards, WWW-based applications, medical collaborative platforms, wireless networking, and the concepts of ambient intelligence and pervasive computing in electronic healthcare systems.
  • 2014 Springer
    Bard, Robert Laurence.
    Image-Guided Prostate Cancer Treatments is a comprehensive reference and practical guide on the technology and application of ultrasound and MRI in the male pelvis, with special attention to the prostate. The book is organized into three main sections, the first of which is devoted to general aspects of imaging and image-guided treatments. The second section provides a systematic overview of the application of ultrasound and MRI to the diagnosis and treatment of diseases of the lower urinary tract. Performance of the ultrasound and MRI studies is explained, and the normal and abnormal pathological anatomy is reviewed. Correlation with the ultrasound in the same plane is provided to assist in understanding the MRI sequences. Biopsy and interventional procedures, ultrasound-MRI fusion techniques, and image-guided therapies, including focused ultrasound, photodynamic therapy, microwave and laser ablation, are all fully covered. The third section focuses on securing treatment effectiveness and the use of follow-up imaging to ensure therapeutic success and detect tumor recurrence at an early stage, which is vital given that prompt focal treatment of recurrence is very successful. Here, particular attention is paid to the role of Doppler ultrasound and DCE-MRI technologies. This book, containing a wealth of high-quality illustrations based on high-end equipment, will acquaint beginners with the basics of prostate ultrasound and MRI, while more advanced practitioners will learn new skills, means of avoiding pitfalls, and ways of effectively relating the imaging and image-guided treatments to the clinical situation.
  • 2002 CRCnetBASE
    Russ, John C.
    This essential resource covers binary image processing, color images, depth resolution, image interpretation problems, thresholding multiband images, among many other areas of image analysis and processing.
  • 2014 CRCnetBASE
    Brock, Kristy Kay.
    "This book provides complete descriptions of the techniques involved in medical image processing, using sufficient descriptions and practical references. Chapters cover topics of deformable registration, segmentation, image reconstruction, and integration of these practices into the radiation therapy environment. The four sections provide an overview of the image segmentation and reconstruction techniques using image processing across all modalities, and applications of these approaches in radiation therapy. The book also addresses the applications of registration, segmentation, and image reconstruction for radiation therapy, including adaptive radiotherapy, monitoring and tracking of treatment delivery, quantifying accuracy, and visualizing results"--Provided by publisher.
  • 2008 Springer
    Bartolozzi, C.; Caramella, D.; Neri, E.
  • Click LINK above for Print location/circulation status.
    2002 CRCnetBASE
    Javidi, Bahram.
  • 2009
    Pratx, Guillem; Hanrahan, P. M.; Levin, Craig; Pauly, John M.
    Molecular imaging can interrogate subtle molecular disease signatures non-invasively in living subjects. Positron emission tomography (PET), one particular molecular imaging modality, is able to sense molecular signals deep within tissue. Although PET is well suited for imaging signals associated with cancerous lesions in humans, it is still unable to resolve very small (< 2 mm) structures. Improving the spatial resolution of PET is an active area of research driven by many potential applications. However, the new generation of high-resolution PET systems raise new challenges for image reconstruction. In this dissertation, several strategies and algorithms are proposed to enable accurate and practical image reconstruction for high-resolution PET. Reconstruction is performed directly from the list-mode data via maximum-likelihood estimation. A shift-varying model of the imaging process is incorporated in the reconstruction. For fast reconstruction, the calculations are implemented using highly-parallel graphics processing units (GPU). A Bayesian sequence reconstruction algorithm is also used to position the annihilation photons that deposit energy in multiple detection elements. We show that the reconstruction provides near-uniform spatial resolution throughout the field-of-view, enhanced trade-off between noise and contrast, and better image quantitative accuracy. Furthermore, thanks to the computing power of graphics hardware, reconstruction times are practical for clinical applications.
  • 2010
    Timmerman, Robert D.; Xing, Lei.
    PrintStatus: Not Checked OutLane Catalog Record
    Introduction to image-guided and adaptive radiotherapy / Martin J. Murphy and Tianfang Li -- Image guided adaptive radiation therapy and practical perspectives / Lei Xing, Louis Lee, and Robert Timmerman -- Errors, margins, localization, and correction / Jan-Jakob Sonke and Marcel van Herk -- Use of implanted fiducial markers in IGRT / Daniel Low and James Balter -- Management of respiratory motion in radiation therapy / Gig S. Mageras and Paul J. Keall -- Image guided stereotactic radiosurgery and stereotactic body radiation therapy / T.D. Solberg, B. Kavanagh, and P.M. Medin -- Three-dimensional conformal brachytherapy : current trends and future promise / Jeffrey F. Williamson and Robert Cormack -- Target definition and localization / Daniel R. Gomez, K.S. Clifford Chao, and Nancy Y. Lee -- PET/CT and biologically conformal radiation therapy / Marco Trovo, Jeffrey Bradley, and Mitchell Machtay -- Head and neck cancers / Ping Xia and Quynh-Thu Le -- Lung cancers / Steve Jiang, Loren Mell, and Ajay Sandhu -- Breast cancers / Sua Yoo ... [et al.] -- Liver malignancies / Kristy K Brock and Laura A. Dawson -- Non-hepatic gastrointestinal malignancies / Daniel T. Chang, Devin S. Schellenberg, and Albert C. Koong -- Genitourinary cancers / Lei Dong and Jeff M. Michalski -- Gynecologic malignancies / Loren K. Mell ... [et al.] -- Central nervous system tumors / Yoshiya Yamada ... [et al.] -- Pediatric cancers / Thomas Merchant and Chris Beltran -- Platforms for image-guided and adaptive radiation therapy / Warren Kilby ... [et al.] -- Quality assurance of image-guided adaptive radiation / Douglas J. Moseley ... [et al.] -- Information systems and data management / Sam Brain and Bruce H. Curran -- Image-guided and adaptive radiation therapy billing and reimbursement / Chet Szerlag, Luis Canovas, and Claire Mendenhall.
  • 2013 Springer
    Dupuy, Damian E.; Fong, Yuman; McMullen, William N.
    Image-Guided Cancer Therapy: A Multidisciplinary Approach provides clinicians with in-depth coverage of the growing, dynamic field of interventional oncology. Combining the knowledge of expert editors and authors into one powerhouse reference, this book looks at tumor ablation, HIFU, embolic therapies, emerging technologies, and radiation therapy throughout the body (liver, bone, breast, gynecologic and prostate cancers, to name just a few), and includes discussion of different imaging modalities. In the words of Peter Mueller, MD, author of the books Foreword: The senior authors are all world renowned experts in interventional oncology, which is another example of the high quality authorship and experience that is brought to this book. The later chapters discuss therapies that are simply not covered in any other source. Everyone who is doing or wants to do ablation therapies and interventional oncology will face a time when they will be asked to use their expertise in less used and less investigated areas. There is nowhere else where the reader can get information on the prostate, breast, and gynecologic areas, and especially pediatrics. This book is an outstanding contribution to the literature and will become a must read for all physicians who are interested in Interventional Oncology.
  • 2006 Springer
    Bortfeld, Thomas.
  • 2008 Springer
    Cleary, Kevin R.; Peters, Terry M.
    Procedural similarities / Douglas Fenton and Jeffrey J. Peterson -- Shoulder injections / Jeffrey J. Peterson -- Elbow injections / Jeffrey J. Peterson and Douglas Fenton, and Leo Czervionke -- A surgeon's perspective / Peter M. Murray -- Wrist and hand injections / Jeffrey J. Peterson and Douglas Fenton, and Leo Czervionke -- Hip injections / Jeffrey J. Peterson -- A surgeon's perspective / Gavan P. Duffy -- Knee injections / Jeffrey J. Peterson -- A surgeon's perspective / Cedric J. Ortiguera -- Ankle and foot injections / Jeffrey J. Peterson -- A surgeon's perspective / James K. DeOrio -- Percutaneous image-guided biopsy and radiofrequency ablation / Jeffrey J. Peterson and Douglas Fenton, and Leo Czervionke -- A surgeon's perspective / Mary I. O'Connor.
  • 2014 ClinicalKey
    Mauro, Matthew A.
    Brief history of image-guided therapy -- Noninvasive vascular diagnosis -- Invasive vascular diagnosis -- Diagnostic catheters and guidewires -- Balloon catheters -- Stents -- Thrombectomy devices -- Embolic protection devices -- Atherectomy devices -- Embolization agents -- Aortic stent-grafts -- Inferior vena cava filters -- Endovascular laser therapy -- Intellectual property management -- Clinical vascular examination -- Treatment of medical emergencies -- Radiation safety and protection in the interventional fluroscopy environment -- Management of risk factors for peripheral artery disease -- Principles of intraprocedural analgesics and sedatives -- Contrast agents -- Principles of thrombolytic agents -- Antiplatelet agents and anticoagulants -- Vasoactive agents -- Antibiotic prophylaxis in interventional radiology -- Angioplasty -- Restenosis -- Principles of arterial access -- Closure devices -- Principles of venous access -- Vascular anatomy of the upper extremity -- Anatomy of the lower limb -- Acute arterial occlusive disease of the upper extremity -- Acute lower extremity ischemia -- Chronic upper extremity ischemia and revascularization -- Aortoiliac revascularization -- Endovascular management of chronic femoropopliteal disease -- Infrapopliteal revascularization -- Subintimal angioplasty -- Management of extremity vascular trauma -- Management of postcatheterization pseudoaneurysms -- Endovascular treatment of peripheral aneurysms -- management of vascular artheritides -- Congential vascular anomalies: classification and terminology -- Management of low-flow vascular malformations -- Management of high-flow vascular anomalies -- Abdominal aorta and the inferior vena cava -- Aortic endografting -- Fenestrated stent-grafting of juxtarenalaortic aneurysms -- Management of thoracoabdominal aneurysms by branched endograft technology -- Endoleaks: classification, diagnosis, and treatment -- Endovascular treatment of dissection ot the aorta and its branches -- Alimentary tract vasculature -- Management of upper gastrointestinal hemorrhage -- Management of lower gastrointestinal bleeding -- Acute mesenteric ischemia -- Chronic mesenteric ischemia -- Renal vasculature -- Renovascular interventions -- Acute renal ischemia -- Renal artery embolization -- Management of renal angiomyolipoma -- Transvenous renal biopsy -- Transjugular liver biopsy -- Chemoembolization of hepatocellular carcinoma -- Radioembolization for hepatocellular carcinoma -- Embolotherapy for the management of liver malignancies other than hepatocellular carcinoma -- Radioembolization of liver metastases -- Bland embolization for hepatic malignancies -- Portal vein embolization -- Vascular intervention in the liver transplant patient -- Management of trauma to the liver and spleen -- Splenic embolization in nontraumatized patients -- Management of visceral aneurysms -- Intraarterial ports for chemotherapy -- Vascular anatomy of the pelvis -- Uterine fibroid embolization -- Peripartum hemorrhage -- Management of pelvic hemorrhage in trauma -- Management of male varicocele -- Management of female venous congestion syndrome.
  • 2008 ClinicalKey
    Czervionke, Leo F.; Fenton, Douglas S.; Peterson, Jeffrey J.
    Procedural similarities / Douglas Fenton and Jeffrey J. Peterson -- Shoulder injections / Jeffrey J. Peterson -- Elbow injections / Jeffrey J. Peterson and Douglas Fenton, and Leo Czervionke -- A surgeon's perspective / Peter M. Murray -- Wrist and hand injections / Jeffrey J. Peterson and Douglas Fenton, and Leo Czervionke -- Hip injections / Jeffrey J. Peterson -- A surgeon's perspective / Gavan P. Duffy -- Knee injections / Jeffrey J. Peterson -- A surgeon's perspective / Cedric J. Ortiguera -- Ankle and foot injections / Jeffrey J. Peterson -- A surgeon's perspective / James K. DeOrio -- Percutaneous image-guided biopsy and radiofrequency ablation / Jeffrey J. Peterson and Douglas Fenton, and Leo Czervionke -- A surgeon's perspective / Mary I. O'Connor.
    Also available: Print – 2008
  • 2012 CRCnetBASE
    Bourland, J. Daniel.
    "Preface This book presents key image-guided radiation treatment (IGRT) technologies for external beam radiotherapy and caps a multidecade phase of technology development in the realm of conformal, customized radiation treatment. This development phase has been somewhat brief and vigorous, with new IGRT innovations such as increased image fidelity and adaptive radiotherapy continuing through the present day. IGRT had been in development in earnest since the early 1990s as a desired companion to intensity-modulated radiation treatment (IMRT). It was known at the time that beam-intensity modulation would be proven to enable beamlets of radiation dose to be formed and delivered to give highly conformal treatment to target volumes, while at the same time providing avoidance of even nearby normal structures. IMRT was being developed with pathways that were based on particular technological features of each vendor's designs for their multileaf collimators (MLCs) and linear accelerators, e.g., leaf design (width, height, focus, speed, etc.), dose rate control, error checking, and gantry motion control. In a previous decade, the 1980s into the mid-1990s, three-dimensional conformal radiation treatment (3D-CRT) had been developed such that for the first time, using static pretreatment 3D images from computed tomography (CT), anatomical volumes could be identified and segmented for the target, normal structures, and the external contour. As 3D-CRT and IMRT technologies developed, it was recognized that confirming "correct" treatment geometry for every individual fraction might be important, since daily variations in treatment position and the locations of internal structures would lead to blurring (degradation) of the cumulative dose distribution"--Provided by publisher.
  • 2010 Springer
    Golovac, Stanley; Mathis, John M.
  • 2002 CRCnetBASE
    Strickland, Robin N.
  • 2009 Springer
    Jacquier, Alexis.
  • 2012 Springer
    Bott, Simon.
    Introduction -- The Production of Radiological and Histopathological Images -- Kidneys and Ureters -- The Adrenal -- The Retroperitoneum -- The Bladder -- The Prostate -- The Testes and Their Adnexae -- The Penis -- Urodynamics.
  • Fred, Herbert L.; Van Dijk, Hendrik A.
  • 2013 Springer
    Polascik, Thomas J.
    Imaging and Focal Therapy of Early Prostate Cancer evaluates the scientific evidence for the evolving trend to treat low to intermediate risk, clinically localized prostate cancer in a focally ablative manner with novel gland-preserving, focal therapy methods. Various ablative devices such as high intensity focused ultrasound, irreversible electroporation, photodynamic therapy, cryotherapy and laser ablation, among others, are discussed in regard to their strengths and limitations as a therapeutic modality. Emphasis is placed on tumor stage shift towards early stage disease with an increase in unilateral versus bilateral cancers validated by final pathology assessment of large prostatectomy series. Current and new approaches to image cancer foci within the prostate (3-Dimensional contrast-enhanced transrectal ultrasonography, multiparametric magnetic resonance image with spectroscopy, ETC) are presented along with biopsy techniques to map prostate cancer. Patient selection, treatment strategy, outcomes and safety concerns that may provide acceptable cancer control and improved quality of life for patients are all covered in detail. Written by experts in the field and lavishly illustrated with detailed line-art and photographs, Imaging and Focal Therapy of Early Prostate Cancer is a resourceful volume beneficial to practitioners specializing in the treatment and management of prostate cancer.
  • 2013
    Nicolson, Malcolm; Fleming, John E. E.
    PrintStatus: Not Checked OutLane Catalog Record
    1. Introcution : historiographies of obstetrics -- 2. Diagnostic ultrasound before Thomas Brown -- 3. Ian Donald before ultrasound I : St. Thomas's Hospital and the Royal Air Force -- 4. Ian Donald before ultrasound II : Hammersmith and Glasgow -- 5. A-scope investigations in Glasgow -- 6. The First contact scanner -- 7. The Automatic scanner and the diasonograph -- 8. "Behind the Iron Curtain" : ultrasound and the fetus -- 9. Diffusion, controversy, and commodification -- 10. Ian Donald after ultrasound : contraception and abortion -- 11. Maternity and technology.
  • 2015 Springer
    Capelli, Paola; D'Onofrio, Mirko; Pederzoli, P.
    Although interest in pancreatic pathology is very high in the radiological and gastroenterological communities, it is still the case that less is known about pathology of the pancreas than about liver pathology, for example. Diagnosis depends on the structure of the pancreatic lesion, which can be directly visualized on US, CT or MR images. This atlas, which encompasses both the imaging and the pathology of pancreatic neoplasms, will therefore be invaluable in enabling radiologists and sonographers to understand the underlying pathology and in allowing pancreatic pathologists to understand the imaging translation. The emphasis in the atlas is very much on the pathological and imaging appearances, with most of the text concentrated at the beginning of the chapters. A comprehensive overview is provided of typical and atypical presentations and diverse aspects of common and uncommon pancreatic neoplasms, including ductal adenocarcinoma, neuroendocrine neoplasms, intraductal papillary mucinous neoplasms, cystic neoplasms, metastases and lymphoma.
  • 2012 ScienceDirect
    Conn, P. Michael.
    Section 1. Viruses, microbes, and parasites. Microbial cells analysis by atomic force microscopy / David Alsteens ; Understanding parasite transmission through imaging approaches / Mirko Singer and Freddy Frischknecht ; Multiphoton microscopy applied for real-time intravital imaging of bacterial infections in vivo / Ferdinand X. Choong ... [et al.] ; Analysis of virus entry and cellular membrane dynamics by single particle tracking / Helge Ewers and Mario Schelhaas ; Imaging of live malaria blood stage parasites / Christof Grüring and Tobias Spielmann ; Escherichia coli K1 invasion of human brain microvascular endothelial cells / Lip Nam Loh and Theresa H. Ward -- Section 2. Disease states. Real-time imaging after cerebral ischemia : model systems for visualization of inflammation and neuronal repair / Pierre Cordeau and Jasna Kriz ; In vivo real-time visualization of leukocytes and intracellular hydrogen peroxide levels during a zebrafish acute inflammation assay / Luke Pase, Cameron J. Nowell, and Graham J. Lieschke ; Imaging protein oligomerization in neurodegeneration using bimolecular fluorescence complementation / Federico Herrera, Susana Gonçalves, and Tiago Fleming Outeiro ; 3D/4D functional imaging of tumor-associated proteolysis : impact of microenvironment / Kamiar Moin ... [et al.] -- Section 3. Other techniques. Live cell imaging in live animals with fluorescent proteins / Robert M. Hoffman ; Protein activation dynamics in cells and tumor micro arrays assessed by time resolved Förster resonance energy transfer / Véronique Calleja, Pierre Leboucher, Banafshe ́Larijani ; Imaging stem cell differentiation for cell-based tissue repair / Zhenghong Lee ... [et al.] ; Understanding the initiation of B cell signaling through live cell imaging / Angel M. Davey ... [et al.] ; A quantitative method for measuring phototoxicity of a live cell imaging microscope / Jean-Yves Tinevez ... [et al.] ; High content screening of defined chemical libraries using normal and glioma-derived neural stem cell lines / Davide Danovi ... [et al.] ; High-throughput screening in primary neurons / Punita Sharma ... [et al.] ; Live imaging fluorescent proteins in early mouse embryos / Panagiotis Xenopoulos, Sonja Nowotschin, and Anna-Katerina Hadjantonakis ; Methods for three-dimensional analysis of dendritic spine dynamics / Enni Bertling ... [et al.] ; Imaging cell competition in Drosophila imaginal discs / Shizue Ohsawa ... [et al.] ; Live cell imaging of the oviduct / Sabine Kölle -- Computational quantification of fluorescent leukocyte numbers in zebrafish embryos / Felix Ellett and Graham J. Lieschke -- Four-dimensional tracking of lymphocyte migration and interactions in lymph nodes by two-photon microscopy / Masahiro Kitano and Takaharu Okada.
  • 2012 ScienceDirect
    Conn, P. Michael.
    Monitoring cytoskeletal dynamics in living neurons using fluorescence photoactivation / Anne Gauthier-Kemper ... [et al.] -- Red/far-red fluorescing DNA-specific anthraquinones for nucl:cyto segmentation and viability reporting in cell-based assays / Roy Edward -- Methods to measure actin treadmilling rate in dendritic spines / Mikko Koskinen, Enni Bertling, and Pirta Hotulainen -- Live-cell imaging of clathrin coats / Comert Kural and Tom Kirchhausen -- Imaging the mitotic spindle / Paul S. Maddox ... [et al.] -- Modeling of spatial intracellular signaling events in neurons / Wendy C. Wenderski and Susana R. Neves -- Imaging chromosome dynamics in meiosis in plants / Moira J. Sheehan and Wojciech P. Pawlowski -- Analyzing lysosomes in live cells / Paul R. Pryor -- Detection and quantification of biomolecular association in living cells using single-molecule microscopy / Mario Brameshuber and Gerhard J. Schütz -- Visualizing cardiac ion channel trafficking pathways / James W. Smyth and Robin M. Shaw -- Live cell imaging of the cytoskeleton / Eve G. Stringham ... [et al.] -- Fluorescence single-molecule imaging of actin turnover and regulatory mechanisms / Naoki Watanabe -- Analysis of cell dispersion and migration by video-microscopy / Bonnomet Arnaud ... [et al.] -- Real time qualitative and quantitative GLUT4 translocation assay / Maleppillil Vavachan Vijayakumar and Manoj Kumar Bhat -- Advanced imaging of cellular signaling events / Marek Cebecauer, Jana Humpolíčková, and Jerémie Rossy -- Dynamic imaging of homo-FRET in live cells by fluorescence anisotropy microscopy / Subhasri Ghosh ... [et al.] -- Time-resolved luminescence resonance energy transfer imaging of protein-protein interactions in living cells / Harsha E. Rajapakse and Lawrence W. Miller -- Imaging of corticosteroid receptors in live cells / Mayumi Nishi -- Investigating second messenger signaling in vivo / Rüdiger Rudolf, Mathias Hafner, and Marco Mongillo -- Probes for intracellular RNA imaging in live cells / Philip J. Santangelo ... [et al.] -- Imaging the glycome in living systems / Boyangzi Li, Feiyan Mock, and Peng Wu -- Intracellular magnesium detection by fluorescent Indicators / Valentina Trapani ... [et al.] -- Illuminating mobile zinc with fluorescence : from cuvettes to live cells and tissues / Zhen Huang and Stephen J. Lippard -- Quantitative fluorescent live cell Imaging of intracellular Ca2+ and H+ ions in malaria parasites / Petra Rohrbach.
  • 2012 ScienceDirect
    Conn, P. Michael.
    Laser-induced radiation microbeam technology and simultaneous real-time fluorescence imaging in live cells / Stanley W. Botchway ... [et al.] -- A cell biologist's guide to high resolution imaging / Graeme Ball ... [et al.] -- Applications of fluorescence lifetime spectroscopy and imaging to lipid domains in vivo / André E.P. Bastos ... [et al.] -- Detecting and tracking nonfluorescent nanoparticle probes in live cells / Gufeng Wang and Ning Fang -- Fluorescence lifetime microscopy of tumor cell invasion, drug delivery, and cytotoxicity / Gert-Jan Bakker ... [et al.] -- Measuring membrane protein dynamics in neurons using fluorescence recovery after photobleach / Inmaculada M. González-González ... [et al.] -- Fluorescent speckle microscopy in cultured cells / Marin Barisic, António J. Pereira, and Helder Maiato -- Green-to-red photoconvertible mEosFP-aided live imaging in plants / Jaideep Mathur ... [et al.] -- Methods for cell and particle tracking / Erik Meijering, Oleh Dzyubachyk, and Ihor Smal -- Correlative light-electron microscopy : a potent tool for the imaging of rare or unique cellular and tissue events and structures / Alexander A. Mironov and Galina V. Beznoussenko -- Optical techniques for imaging membrane domains in live cells (live-cell palm of protein clustering) / Dylan M. Owen ... [et al.] -- Single live cell topography and activity imaging with the Shear-Force-Based Constant-Distance Scanning Electrochemical Microscope / Albert Schulte, Michaela Nebel, and Wolfgang Schuhmann -- Visualization of TGN-endosome trafficking in mammalian and drosophila cells / Satoshi Kametaka and Satoshi Waguri -- Live cell imaging with chemical specificity using dual frequency CARS microscopy / Iestyn Pope ... [et al.] -- Imaging intracellular protein dynamics by Spinning Disk Confocal microscopy / Samantha Stehbens ... [et al.] -- Visualizing dynamic activities of signaling enzymes using genetically encodable FRET-based biosensors : from designs to applications / Xin Zhou, Katie J. Herbst-Robinson, and Jin Zhang -- Live-cell imaging of Aquaporin-4 supramolecular assembly and diffusion / A.S. Verkman, Andrea Rossi, and Jonathan M. Crane -- Coiled-coil tag-probe labeling methods for live-cell imaging of membrane receptors / Yoshiaki Yano ... [et al.] -- Monitoring protein interactions in living cells with fluorescence lifetime imaging microscopy / Yuansheng Sun ... [et al.] -- Open source tools for fluorescent imaging / Nicholas A. Hamilton -- Nanoparticle PEBBLE sensors in live cells / Yong-Eun Koo Lee and Raoul Kopelman.
  • 2012 Springer
    Eardley, Ian; O'Flynn, Kieran; Payne, S. R.
    Part 1. Imaging: Radiology -- Principles of X-Ray Production and Radiation Protection / Christopher T. L. Wilkinson -- How to Perform a Clinical Radiograph and Use a C-Arm / Christopher T. L. Wilkinson -- Contrast Agents / Paul M. Taylor -- How to Do an IVU / Paul M. Taylor -- Dual Energy X-Ray Absorptiometry (DXA) / Richard Whitehouse -- The Physics of Ultrasound / Paul M. Taylor -- How to Ultrasound a Suspected Renal Mass / Michael J. Weston -- How to Ultrasound a Painful Testis and a Testicular Mass / Michael J. Weston -- How to Perform a Transrectal Ultrasound Scan and Prostate Biopsy / Fady Youssef and John B. Anderson -- How to Manage a Hydronephrotic Kidney / Michael J. Weston -- Principles of Computed Tomography (CT) / Catherine O'Dwyer -- How to Do a CT Urogram (CTU) / Paul M. Taylor -- How to Do a CT in a Patient with Presumed Upper Tract Trauma / Jonathan Smith -- Principles of Magnetic Resonance Imaging (MRI) / Jonathan Smith -- How to Do an MRI of the Pelvis / Jonathan Smith -- Magnetic Resonance Angiography (MRA) / Kieran O'Flynn -- Vascular Embolisation Techniques in Urology / Alistair Cowie. Part 2. Imaging: Nuclear Medicine -- Radionuclides and Their Uses in Urology / Richard Lawson -- Counting and Imaging in Nuclear Medicine / Richard Lawson -- Principles of Positron Emission Tomography (PET) Scanning / Heather A. Williams -- How to Do a Renogram / Mary Prescott -- How to Do a Diuresis Renogram / Mary Prescott -- How to Do a DMSA Scan / Jackie James -- How to Do a Radioisotope Glomerular Filtration Rate Study / Richard Lawson -- How to Do a Bone Scan / Mary Prescott -- How to Do a Transplant Renogram / Mary Prescott -- Dynamic Sentinel Lymph Node Biopsy in Penile Cancer / Hussain M. Alnajjar and Nicholas A. Watkin -- Part 3. Technology: Diagnostic -- Urinalysis / David G. Ross -- Principles of Urine Microscopy and Microbiological Culture / Chinari P. K. Subudhi -- Measurement of Glomerular Filtration Rate (GFR) / Stephen Brown -- Metabolic Assessment of Urinary Tract Stones / Adrian D. Joyce -- Principles of Pressure Measurement / Ian Pearce -- Principles of Measurement of Urinary Flow / Richard Napier-Hemy -- How to Carry Out a Videocystometrogram (VCMG) / Alexander Springer, Ian Eardley and Ramnath Subramaniam -- The Whitaker Test / Jeremy Oates and Kieran O'Flynn -- Sphincter Electromyography (EMG) / Katherine E. Burnett and Christopher D. Betts -- Tumour Markers / Richard Khafagy and William Cross -- Urine Cytology / William Cross and Richard Khafagy -- Histopathological Processing, Staining, and Immuno-histochemistry / Lorna McWilliam. Part 4. Technology: Operative -- Principles of Urological Endoscopes / Luke Gordon -- Rigid Endoscope Design / Luke Gordon -- Light Sources, Light Leads, and Camera Systems / Stuart N. Lloyd and Adrian D. Joyce -- Peripherals for Endoscopic Use / Stuart N. Lloyd and Steve Payne -- Peripherals for Laparoscopic Use / Andrew Sinclair -- Peripherals for Mechanical Stone Manipulation / Karyee Chow -- Contact Lithotripters / Steve Payne -- Endoscopic Use of Laser Energy / Omar Al Kadhi and Tev Aho -- Double J Stents and Nephrostomy / Steve Payne -- Urinary Catheters, Design, and Usage / Dave Shackley -- Prostatic and Urethral Stents / Ian Eardley -- Urological Prosthetics / Duncan J. Summerton and Ian Eardley -- Meshes in Stress Urinary Incontinence and Pelvic Organ Prolapse / Neil Harris -- Biological Meshes / Ian Eardley, Giulio Garaffa and David J. Ralph -- Principles of Tissue Transfer in Urology / Giulio Garaffa, David J. Ralph and Ian Eardley -- Theatre Design and Patient Safety / Pat McHugh and Steve Payne -- Deep Venous Thrombosis (DVT) Prevention / Pat McHugh -- Principles of Decontamination / Geoff J. H. Sjogren and Ralph Beard -- Operative Tissue Destruction / Steve Payne -- Sutures and Clips / Derek Fawcett -- Monopolar Diathermy / Kieran O'Flynn -- Bipolar Diathermy / Kieran O'Flynn -- Alternatives to Electrosurgery / Adrian D. Joyce -- Haemostatic Agents, Sealants, and Adhesives / Ian Eardley -- Irrigation Fluids and Their Hazards / Stuart N. Lloyd -- Insufflants and Their Hazards / Stephen Bromage and Andrew Sinclair -- Laparoscopic Ports / Ben Sherwood and Dan Burke -- Setting up a Robot / Ben Sherwood and Dan Burke. Part 5. Technology: Interventional -- Neuromodulation by Sacral Nerve Stimulation / Cecile Tawadros, Katherine E. Burnett and Christopher D. Betts -- Principles of Extracorporeal Shockwave Lithotripsy (ESWL) / Richard Napier-Hemy and Steve Payne -- How to Carry Out Shockwave Lithotripsy / David G. Ross -- Prostatic Hyperthermia / Ian Pearce -- Ablative Therapies: High-Intensity Focused Ultrasound (HIFU), Cryotherapy, and Radio-Frequency Ablation (RFA) / Stephen Brown -- Principles of Radiotherapy / John P. Logue -- Electro-Motive Drug Administration (EMDA) / Vijay Sangar -- Part 6. Technology of Renal Failure -- Principles of Renal Replacement Therapy (RRT) / Colin D. Short -- Principles of Peritoneal Dialysis / Philip A. Kalra -- Haemodialysis / Rosie Donne -- Principles of Renal Transplantation / Neil R. Parrott -- Part 7. Assessment of Technology -- Randomised Controlled Trials (RCTs) / Kieran O'Flynn -- Health Technology Assessment / Robert Pickard, Michael Drinnan and Luke Vale.
  • 2013 Springer Protocols
    Turksen, Kursad.
    Primary Culture and Live Imaging of Adult Neural Stem Cells and Their Progeny / Felipe Ortega, Benedikt Berninger, and Marcos R. Costa -- Labeling and Tracking of Human Mesenchymal Stem Cells Using Near-Infrared Technology / Marie-Therese Armentero, Patrizia Bossolasco, and Lidia Cova -- High Content Imaging and Analysis of Pluripotent Stem Cell-Derived Cardiomyocytes / Gábor Földes and Maxime Mioulane -- A High Content Imaging-Based Approach for Classifying Cellular Phenotypes / Joseph J. Kim, Sebastián L. Vega, and Prabhas V. Moghe -- Conversion of Primordial Germ Cells to Pluripotent Stem Cells: Methods for Cell Tracking and Culture Conditions / Go Nagamatsu and Toshio Suda -- Imaging and Tracking of Bone-Marrow-Derived Immune and Stem Cells / Youbo Zhao [and four others] -- Co-Visualization of Methylcytosine, Global DNA, and Protein Biomarkers for In Situ 3-D DNA Methylation Phenotyping of Stem Cells / Jian Tajbakhsh -- Noninvasive Imaging of Myocardial Blood Flow Recovery in Response to Stem Cell Intervention / HuaLei Zhang and Rong Zhou -- Live Imaging of Early Mouse Embryos Using Fluorescently Labeled Transgenic Mice / Takaya Abe, Shinichi Aizawa, and Toshihiko Fujimori -- Live Imaging, Identifying, and Tracking Single Cells in Complex Populations In Vivo and Ex Vivo / Minjung Kang [and four others] -- Quantitative Evaluation of Stem Cell Grafting in the Central Nervous System of Mice by In Vivo Bioluminescence Imaging and Postmortem Multicolor Histological Analysis / Kristien Reekmans [and eight others] -- Micro-CT Technique for Three Dimensional Visualization of Human Stem Cells / Andrea Farini [and four others] -- Noninvasive Multimodal Imaging of Stem Cell Transplants in the Brain Using Bioluminescence Imaging and Magnetic Resonance Imaging / Annette Tennstaedt [and three others] -- Magnetic Resonance Imaging and Tracking of Stem Cells / Hossein Nejadnik, Rostislav Castillo, and Heike E. Daldrup-Link -- Whole Body MRI and Fluorescent Microscopy for Detection of Stem Cells Labeled with Superparamagnetic Iron Oxide (SPIO) Nanoparticles and DiI Following Intramuscular and Systemic Delivery / Boris Odintsov, Ju Lan Chun, and Suzanne E. Berry -- Molecular Imaging and Tracking Stem Cells in Neurosciences / Toma Spiriev, Nora Sandu, and Bernhard Schaller -- Bioluminescence Imaging of Human Embryonic Stem Cells-Derived Endothelial Cells for Treatment of Myocardial Infarction / Weijun Su [and four others].
  • 2010 Springer
    Patel, Uday.
    Part 1. The Bladder -- The Normal Bladder -- Imaging Modalities Used for Assessment of the Bladder -- Congenital Anomalies of the Bladder -- Intraluminal Abnormalities of the Bladder -- Abnormalities of the Bladder Wall or Mural Abnormalities -- Staging of Bladder Cancer -- Abnormal Bladder Contour or Size -- Functional Abnormalities of the Bladder -- Part 2. The Urethra -- The Normal Urethra -- Congenital Anomalies of the Urethra -- Intraluminal Abnormalities and Filling Defects of the Urethra -- Intrinsic Abnormalities of the Urethral Wall -- Lower Urinary Tract Trauma -- Neoplasms of the Urethra.
  • 2015 Springer
    Fong, Yuman.
    Basis of practice -- Lighting in the Operative Room: Current Technologies and Considerations -- Modalities for Intraoperative Imaging -- Fluorescents Probes -- Detectors for Intraoperative Molecular Imaging: From Probes to Scanners -- Isotopes and Procedural Imaging -- Radiologically Imageable Nanoparticles -- Flat Panel CT and the Future of OR imaging and Navigation -- Cerenkov Luminescence Imaging -- Organ Deformation and Navigation -- Clinical Milestones for Optical Imaging -- 3D in the Minimally Invasive Surgery (MIS) Operating Room: Cameras and Displays in the Evolution of MIS -- Molecular Tumor Marker Recognition: Nanotechnology for On-Line Diagnostics in the OR -- Ultra Small Fluorescent Silica Nanoparticles as Intraoperative Imaging Tools for Cancer Diagnosis and Treatment -- Image Processing Technologies for Motion Compensation -- Current Clinical Applications -- Near Infra-red Imaging in Robotic Surgery -- New Preoperative Images, Surgical Planning and Navigation -- New Generation Radiosurgery -- Breast Lesion Localization -- Intraoperative Breast Imaging and Image-Guided Treatment Modalities -- Sentinel Lymph Node Mapping: Current Practice and Future Developments -- Narrow Band Cystoscopy -- Fluorescence Imaging of Human Bile and Biliary Anatomy -- PET Guided Interventions from Diagnosis to Treatment.
  • 2011 ClinicalKey
    Weir, Jamie.
    Head, neck, and brain -- Vertebral column and spinal cord -- upper limb -- Thorax -- Abdomen and pelvis- cross-sectional -- Abdomen and pelvis- non cross-sectional -- Lower limb -- Nuclear medicine.
  • 2008 Springer
    Pescatori, Mario.
  • 2013 Springer
    Freeman, Walter J.; Quian Quiroga, Rodrigo.
    The scalp and cortex lie like pages of an open book on which the cortex enciphers vast quantities of information and knowledge. They are recorded and analyzed as temporal and spatial patterns in the electroencephalogram and electrocorticogram. This book describes basic tools and concepts needed to measure and decipher the patterns extracted from the EEG and ECoG. This book emphasizes the need for single trial analysis using new methods and paradigms, as well as large, high-density spatial arrays of electrodes for pattern sampling. The deciphered patterns reveal neural mechanisms by which brains process sensory information into percepts and concepts. It describes the brain as a thermodynamic system that uses chemical energy to construct knowledge. The results are intended for use in the search for the neural correlates of intention, attention, perception and learning; in the design of human brain-computer interfaces enabling mental control of machines; and in exploring and explaining the physicochemical foundation of biological intelligence.
  • 2012 Springer
    Anzidei, Michele; Catalano, C.; Napoli, Alessandro.
    Angio-TC / Michele Anzidei, Guendalina Menichini and Carlo Catalano -- Angio-RM / Michele Anzidei, Guendalina Menichini and Carlo Catalano -- Post-processing / Pietro Sedati, Fulvio Zaccagna and Carlo Augusto Mallio -- La placca aterosclerotica / Ilaria Iacucci, Luca Saba and Michele Anzidei -- Il circolo intracranico / Eytan Raz, Emanuele Tinelli, Francesca Caramia and Ferdinando D'Ambrosio -- Arterie carotidi / Beatrice Cavallo Marincola, Eugenio Marotta and Michele Anzidei -- Aorta toracica / Nicola Galea, Matteo Mangia and Ilaria Iampieri -- Circolo polmonare / Alessandro Napoli, Federica Ciolina and Luca Bertaccini -- Circolo coronarico / Marco Francone, Francesco Vullo, Bettina Conti and Giuseppe Cannavale -- Aorta addominale / Eugenio Marotta, Maurizio Del Monte and Carlo Catalano -- Arterie renali e vasi splancnici / Pietro Sedati, Fulvio Zaccagna and Riccardo Rosati -- Arti superiori / Alessandro Napoli, Gaia Cartocci and Pier Luigi Di Paolo -- Arti inferiori / Beatrice Cavallo Marincola, Giulia Brachetti and Carlo Catalano -- Whole body / Alessandro Napoli, Fulvio Zaccagna, Luisa Di Mare and Flavio Malpassini -- Malformazioni artero-venose / Fabrizio Fanelli, Pierleone Lucatelli and Massimiliano Allegritti -- Vasculiti / Chiara Zini, Vincenzo Noce and Fabrizio Boni -- Sistema venoso / Francesco Fraioli, Goffredo Serra and Matteo Paoletti.
  • 2007 Springer
    Frischknecht, Friedrich; Shorte, Spencer L.
    Considerations for routine imaging -- Entering the portal: understanding the digital image recorded through a microscope -- Quantitative biological image analysis -- The open microscopy environment: a collaborative data modeling and software development project for biological image informatics -- Design and function of a light-microscopy facility -- Advanced methods and concepts -- Quantitative colocalisation imaging: concepts, measurements, and pitfalls -- Quantitative FRET microscopy of live cells -- Flourescence photobleaching and flourescence correlation spectroscopy: two complementary technologies to study molecular dynamics in living cells -- Single fluorescent molecule tracking in live cells -- From live-cell microscopy to molecular mechanisms: deciphering the functions of kinetochore proteins -- Cutting edge applications & utilities -- Towards imaging the dynamics of protein signalling -- New technologies for imaging and analysis of individual microbial cells -- Imaging parasites in vivo -- Computer-assisted systems for dynamic 3D reconstruction and motion analysis of living cells -- High-throughput/high-content automated image acquisition and analysis -- Cognition network technology: a novel multimodal image analysis technique for automatic identification and quantification of biological image contents -- High-content phenotypic cell-based assays.
  • 2013 Springer
    Dowe, David A.; Fioranelli, Massimo; Pavone, Paolo.
    Clinical anatomy of the coronary circulation -- Basic techniques in the acquisition of cardiac images with CT -- Examination of the coronary arteries -- Image reconstruction -- Coronary pathophysiology -- Clinical classification of coronary artery disease : who should be treated? -- Intravascular ultrasound : from gray-scale to virtual histology -- Identification and characterization of the atherosclerotic plaque using coronary CT angiography -- Coronary CT angiography : evaluation of stenosis and occlusion -- Current strategies in cardiac surgery -- Coronary CT angiography : evaluation of coronary artery bypass grafts -- Coronary stents -- CT angiography of coronary stents -- X-ray exposure in coronary CT angiography -- Optical coherence tomography in the cathlab -- Triple rule out : the use of cardiac CT in the emergency room -- Contraindications to coronary CT angiography -- Prognostic value of coronary CT -- Clinical cases.
  • 2014 Springer
    Crowe, Tim; Nicholls, Stephen J.
    This book presents a comprehensive overview of the major approaches to the imaging of the coronary arteries. These modalities, which include traditional angiography as well as intravascular and non-invasive imaging techniques, are used to diagnose and quantify the extent of obstructive disease due to atherosclerosis. Featuring contributions from leading authorities in the field, Imaging Coronary Atherosclerosis describes the visualization of coronary atherosclerosis through state-of the art techniques such as intravascular ultrasound, coronary near-infrared spectroscopy, computed tomography angiography, magnetic resonance imaging, and molecular imaging. This authoritative resource discusses how these modalities enhance the understanding of the disease process and the ways in which cardiologists can integrate them into clinical practice.
  • 2009 Springer
    Caudana, Roberto; Defilippi, Claudio; Martino, Fabio.
  • 2009 Springer
    Alcala Mata, L.; Luna, A.; Ribes, Ramón; Ros, Pablo R.
  • 2012 Springer
    Avni, E. F.
    Imaging Endocrine "Diseases" in the Fetus / F. E. Avni, F. Rypens, M. Cassart -- Hypophysis and Hypothalamus / Pierre Bessou, Sylviane Hanquinet -- Imaging of the Thyroid and Parathyroid Gland / Rick R. van Rijn, Hein J. Verberne -- Adrenals / Anne M. J. B. Smets, Eline E. Deurloo -- Ambiguous Genitalia / Cinzia Orazi, Marco Cappa, Paolo M. S. Schingo -- Female Pelvis: Precocious Puberty--Primary Amenorrhea / Laurent Garel -- Imaging Endocrine Diseases in Children / K. Rosendahl -- Pancreas / Philippe Petit.
  • 2007
    Brody, Alan S.; Rosenfeld, Margaret; Tiddens, Harm A. W. M.
  • 2011 Thieme Book
    Dunnebier, Erwin A.
    Radiological techniques and interpretation -- Radiological anatomy of the temporal bone -- Pathology of the temporal bone -- Radiological anatomy of the skull base -- Pathology of the skull base -- Radiological anatomy of the nasal cavity and paranasal sinuses -- Pathology of the nasal cavity and paranasal sinuses -- Radiological anatomy of the neck -- Pathology of the neck.
  • 2007
    Lisle, David.
    PrintStatus: Not Checked OutLane Catalog Record
  • 2013 Springer Protocols
    Shav-Tal, Yaron.
    As imaging technologies and approaches have evolved, the scope of certain imaging techniques has moved far beyond the production of purely illustrative images or appealing time-lapse movies to providing the scientist with a rich range of ways to measure and quantify the biological process and outcome of gene expression. In Imaging Gene Expression: Methods and Protocols, expert authors offer up-to-date approaches and protocols that scientists in the field have developed, which would benefit the broader scientific community. Divided in three convenient parts, this detailed book covers the output of a gene, namely the RNA molecules that are transcribed from the gene and the way by which these molecules can be tracked or quantified in fixed or living cells, protocols that focus on the gene, DNA, or chromatin, as well as a variety of ways by which nuclear processes intertwined with gene expression can be followed and quantified in living cells as well as approaches for studying several sub-nuclear structures found in eukaryotic cells. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective subjects, lists of materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and up-to-date, Imaging Gene Expression: Methods and Protocols will serve researchers working toward imaging in the context of complete organisms.
  • 2012 Springer
    Scarabino, T.
    This atlas is a detailed guide to the imaging appearances of gliomas following treatment with neurosurgery, radiation therapy, and chemotherapy. Normal and pathological findings are displayed in detailed MR images that illustrate the potential modifications due to treatment. Particular emphasis is placed on characteristic appearances on the newer functional MR imaging techniques, including MR spectroscopy, diffusion-weighted imaging, and perfusion imaging. These techniques are revolutionizing neuroradiology by going beyond the demonstration of macroscopic alterations to the depiction of preceding metabolic changes at the cellular and subcellular level, thereby allowing earlier and more specific diagnosis. A key section comprising some 40 clinical cases and more than 500 illustrations offers an invaluable clinical and research tool not only for neuroradiologists but also for neurosurgeons, radiotherapists, and medical oncologists.
  • pt. A-B, 2004. ScienceDirect
    pt. B ScienceDirect
    Conn, P. Michael.
    Also available: Print – pt. A-B, 2004.
  • 2013 CRCnetBASE
    Abdul Rahim, Nur Aida; Yu, Hanry.
    "This book covers the full range of available imaging modalities and optical methods used to help evaluate material and biological behavior. It also highlights a wide range of optical and biological applications. Each chapter in the text describes a specific application and discusses relevant instrumentation, governing physical principles, data processing procedures, as well as advantages and disadvantages of each modality. Following a broad introduction to key topics, the main chapters are divided between in vitro and in vivo applications. The final section focuses on methods for data processing and analysis"--Provided by publisher.
  • 2014 Springer
    Gouliamos, Athanasios D.
    Part I. Introduction to oncologic imaging -- Part II. Bone and soft tissue tumors -- Part III. CNS tumors -- Part IV. Lung cancer -- Part V. Head and neck cancer -- Part VI. Lymphomas -- Part VII. Gynecologic cancer -- Part VIII. Breast cancer -- Part IX. Gastrointestinal cancer -- Part X. Neuroendocrine tumors -- Part XI. Urogenital cancer -- Part XII. Melanoma.
  • 2010 Springer
    Borsook, David.
  • 2013 Springer
    Giussani, Augusto; Hoeschen, Christoph.
    This volume addresses a wide range of issues in the field of nuclear medicine imaging, with an emphasis on the latest research findings. Initial chapters set the scene by considering the role of imaging in nuclear medicine from the medical perspective and discussing the implications of novel agents and applications for imaging. The physics at the basis of the most modern imaging systems is described, and the reader is introduced to the latest advances in image reconstruction and noise correction. Various novel concepts are then discussed, including those developed within the framework of the EURATOM FP7 MADEIRA research project on the optimization of imaging procedures in order to permit a reduction in the radiation dose to healthy tissues. Advances in quality control and quality assurance are covered, and the book concludes by listing rules of thumb for imaging that will be of use to both beginners and experienced researchers.
  • 2009 Springer
    Harisinghani, Mukesh G.; Manyak, Michael J.; Rosette, Jean J. M. C. H. de la; Wijkstra, Hessel.
  • 2008 Springer
    Blake, Michael A.; Kalra, M. K.
    Anatomic, physiologic and metabolic imaging in neuro-oncology / Sanjeev Chawla, Harish Poptani, and Elias R. Melhem -- Imaging of spinal tumors / Izlem Izbudak ... [et al.] -- PET imaging of brain tumors / Alan J. Fischman -- Extracranial head and neck neoplasms: role of imaging / Myria Petrou and Suresh K. Mukherji -- Imaging of thoracic malignancies / Subba R. Digumarthy and Suzanne L. Aquino -- Imaging of mediastinal tumors / Scott Moore, Hetal Dave-Verma, and Ajay Singh -- Imaging cardiac tumors / Mannudeep K. Kalra and Suhny Abbara -- Diagnostic imaging and image-guided interventions of hepatobiliary malignancies / Unni Udayasankar ... [et al.] -- Recent advances in imaging of pancreatic neoplasms / Chad B. Rabinowitz, Hima B. Prabhakar, and Dushyant V. Sahani -- Imaging of colorectal carcinoma / Jorge A. Soto -- Imaging of primary malignant tumors of peritoneal and retroperitoneal origin / J. Louis Hinshaw and Perry J. Pickhardt -- Imaging of urinary tract tumors / Michael A. Blake and Mannudeep K. Kalra -- Current status of imaging for adrenal malignant involvement / Michael A. Blake and Mannudeep K. Kalra -- Recent advances in imaging of male reproductive tract malignancies / Jurgen J. Fütterer and J. Roan Spermon -- Imaging of malignant skeletal tumors / Jay Pahade, Aarti Sekhar, and Sanjay K. Shetty -- Radiology of soft tissue tumors including melanoma / M.J. Shelly, P.J. MacMahon, and S. Eustace -- Reticuloendothelium malignancy: current role of imaging / Sunit Sebastian and Brian C. Lucey -- Pediatric malignancies: synopsis of current imaging techniques / Sabah Servaes ... [et al.] -- Interventional radiology in oncology / O.J. O'Connor, J. M. Buckley, and M. M. Maher -- Breast tumor imaging / Deirdre Coll
    Also available: Print – 2008
  • 2012 Springer
    Cleveland, Robert H.
    Imaging in Pediatric Pulmonology is a definitive reference to imaging and differential diagnosis for pediatric pulmonology. Diseases and disorders seen in everyday clinical practice are featured, including infections, developmental disorders, airway abnormalities, diffuse lung diseases, focal lung diseases, and lung tumors. Organized to support the clinical thought process, the text begins with a series of clinical algorithms that provide a starting point for formulating a diagnosis. The physician will be able to identify the differentials by symptom complex and accordingly determine what test would be effective and how to proceed. The balance of the book is image-based and presents a comprehensive, multi-modality approach, with an emphasis on plain film and cross-sectional imaging. The imaging sections are correlated with pathology and clinical findings to help readers learn what the modality of choice can enable them to see. Edited by Robert H. Cleveland, MD, Professor of Radiology at Harvard Medical School and Chief of the Division of Diagnostic Radiology at Children's Hospital Boston, the book includes a talented group of associate editors and contributing authors who are noted experts in pathology, pulmonology, and radiology, making Imaging in Pediatric Pulmonology an ideal reference for all physicians involved in the diagnosis and treatment of pediatric pulmonary issues.
  • 2008 Springer
    Bache, E.; Johnson, K.
  • 2008 Springer
    Antretter, H.; Bankier, Alexander A.
  • 2005 Springer
    Antonelli, A. R.; Maroldi, R.; Nicolai, P.
    Also available: Print – 2005
  • 2010
    Klein, Lawrence Otto; Crabtree, Gerald R.; Davis, Mark M.; Meyer, Tobias.
    This thesis is organized in four chapters. Chapter I is intended to give a general introduction to αβ T cells, their role in the immune system, their T cell receptor (TCR), and the specific TCR transgenic system used in this work. In chapter II the TCR signaling pathway is introduced, and a photoactivation method we developed for interrogating proximal events in this pathway is described. We describe experiments using this method that defined delay times between TCR-pMHC binding and initiation of various TCR proximal signaling events. We found delays much shorter than previous measurements suggested, and propose that they may represent a feature of the pathway predicted by the kinetic-proofreading model of TCR signaling. In this chapter we also describe experiments that took advantage of the ability to precisely define a sub-cellular region of TCR stimulation to interrogate the spatial dynamics of TCR signaling. We found that the T cell membrane was compartmentalized such that even rapidly diffusible second-messengers were confined to the local region of stimulation. By stimulating distinct regions of T cells sequentially, we showed that desensitization occurred rapidly in some branches of the TCR signaling pathway but not at all in others. In chapter III we introduce previous research that sought to define properties of the TCR-pMHC interaction that determine stimulatory potency, and explain how these studies have led to interest in measuring kinetic parameters of the TCR-pMHC interaction in a native two-dimensional environment. We describe development of a new method to measure two-dimensional kinetics using a combination of our photoactivation system and direct detection of receptor-ligand binding via FRET. Using this method we showed that the rate of pMHC binding in a T cell contact interface was not influenced by a variety of cellular factors, but was defined by the kinetics of TCR-pMHC binding measured in vitro. We developed a quantitative method for analyzing our data and found that it fit very well to a simple bimolecular binding model, yielding kinetic parameters in clear agreement with 3D in vitro measurements. Our technique allowed direct, bulk measurement of 2D receptor-ligand binding and has the potential to measure kinetics too fast to measure by previous methods. Finally, in chapter IV we discuss earlier work describing molecular movements that occur during formation of the T cell-APC contact, called the immunological synapse. We describe the results of a series of experiments using our combined FRET and photoactivation assay that revealed the dynamics of TCR-pMHC interactions during immunological synapse formation. Our experiments showed that ligand binding was initiated in small clusters that were stable for tens of seconds while being actively transported toward the center of the cell. We describe the interesting observations that TCR-pMHC binding occurred in a distribution more heterogeneous than either the receptor or ligand distribution, and was regulated by cytoskeletal activity. We showed that in naïve cells this distribution was markedly different than in antigen-experienced cells, indicating that these two cell types may search for antigen in different ways. The results in this chapter indicate that molecular interactions in the synapse are actively regulated by cellular processes and are much more complex than would be expected from measurements of molecular distributions.
  • 2010 Springer
    Setou, Mitsutoshi.
  • 2008 Springer
    Grassi, Roberto; Romano, Luigia; Rotondo, Antonio; Scaglione, Mariano.
  • 2012 Springer
    Gevenois, P. A.; Keyzer, Caroline.
  • 2015 Springer
    Pinto, Antonio; Romano, Luigia.
    This book provides an overview on the critical role of diagnostic imaging in the assessment of patients with suspected alimentary tract perforation, an emergent condition that requires prompt surgery. With the aid of numerous high-quality images, it is described how different imaging modalities, including plain film X-ray, ultrasonography, and multidetector row computed tomography (MDCT), permit correct diagnosis of the presence and cause of the perforation and of associated pathologies. Particular attention is paid to MDCT, with full description of its role in a range of scenarios at various levels of the alimentary tract. Imaging of GI tract perforation in different patient groups, such as pediatric patients, the elderly, and oncologic patients, is also addressed. This volume will greatly assist residents in radiology, radiologists, and physicians who are daily involved in the management of patients with clinically suspected alimentary tract perforation.
  • 2009 ClinicalKey
    Weissman, Barbara N. W.
    Get state-of-the-art coverage of the full range of imaging techniques available to assist in the diagnosis and therapeutic management of rheumatic diseases. Written by acknowledged experts in musculoskeletal imaging, this richly illustrated, full-color text presents the latest diagnostic and disease monitoring modalities - MRI, CT, ultrasonography, nuclear medicine, DXA, as well as interventional procedures. You'll find comprehensive coverage of specific rheumatic conditions, including osteoarticular and extraarticular findings. This superb new publication puts you at the forefront of imaging in arthritis and metabolic bone disease, a must have reference for the clinician and imaging specialist. Includes all imaging modalities relevant to rheumatic disease, and applications and contraindications of each, for balanced coverage. Incorporates a user-friendly, consistent full-color format for quick and easy reference. Provides osteoarticular and extra-articular features and findings to show how imaging benefits diagnosis and management of complex rheumatologic conditions. Creates a one-stop shop with comprehensive coverage of imaging for all rheumatic conditions, including metabolic conditions and pediatric disorders. Presents interventional techniques, injections, arthrography, radiofrequency ablation, to create the perfect diagnostic and interventional clinical tool.
  • 2009 Springer
    Davies, A. M.; James, S. L. J.; Sundaram, Murali.
  • 2011 Springer
    Drevelegas, Antonios.
    Epidemiology, histologic classification, and clinical course of brain tumors -- Imaging modalities in brain tumors -- Molecular abnormalities in gliomas -- The clinical applicability of fMRI and DTI in patients with brain tumors -- Low-grade gliomas -- High-grade gliomas -- Pineal tumors -- Embryonal tumors -- Tumors of the cranial nerves -- Meningeal tumors -- Central nervous lymphomas and hemopoietic neoplasms -- Masses of the sellar and junxtasellar region -- Brain metastasis -- Scintigraphy for brain tumors.
  • 2007 Springer
    Schaller, Bernhard.
  • 2010 ClinicalKey
    Hansell, David M.; Armstrong, Peter; Bankier, Alexander A.; Lynch, David A.; McAdams, H. Page.
    Technical considerations -- The normal chest -- Basic patterns in lung disease -- Basic HRCT patterns of lung disease -- Infections of the lungs and pleura -- The immunocompromised patient -- Pulmonary vascular diseases and pulmonary edema -- Inhalational lung disease -- Drug- and radiation-induced lung disease -- Idiopathic interstitial pneumonias and immunologic diseases of the lungs -- Idiopathic diffuse lung diseases -- Diseases of the airways -- Neoplasms of the lungs, airways, and pleura -- Mediastinal and aortic disease -- Pleura and pleural disorders -- Congenital anomalies -- Chest trauma.
    Also available: Print – 2010
  • 2014 Springer
    Pinto, Antonio; Romano, Luigia.
    Most ingested foreign bodies pass through the gastrointestinal tract without a problem. However, both ingested and inserted foreign bodies may cause serious complications, such as bowel obstruction or perforation. Foreign body aspiration is common in children, especially those under 3 years of age, and in these cases chest radiography and CT are the main imaging modalities. This textbook provides a thorough overview of the critical role of diagnostic imaging in the assessment of patients with suspected foreign body ingestion, aspiration, or insertion. A wide range of scenarios are covered, from the common problem of foreign body ingestion or aspiration in children and mentally handicapped adults through to drug smuggling by body packing and gunshot wounds. Guidance is offered on diagnostic protocols, and the value of different imaging modalities in different situations is explained. Helpful management tips are also provided. This textbook will prove invaluable for residents in radiology, radiologists, and physicians who are involved on a daily basis, within an emergency department, in the management of patients with suspected ingestion, aspiration, or insertion of foreign bodies.
  • 2012 Springer
    Blair, Joanne C.; Garden, A. S.; Mann, Gurdeep S.
    Diagnostic imaging techniques -- Embryology of the female reproductive tract -- Disorders of sex development -- Gynaecological disorders in the neonate and young child -- Structural abnormalities of the female reproductive tract -- Normal growth and puberty -- Delayed precocious puberty -- Menstrual disorders and vaginal discharge -- Gynaecological causes of pelvic pain -- Gynaecological neoplasia -- Breast disorders -- Index.
  • 2006 Springer
    Guermazi, Ali.
  • 2015 Springer
    Sencha, A. N.
    This book is devoted to the diagnosis and treatment of male breast pathology. It provides a comprehensive overview of current strategies for the diagnosis of breast malignancies in men, with a focus on imaging modalities. Ultrasound of male breast abnormalities is discussed in particular depth, but the roles of other imaging techniques, genetic tests, and interventional diagnostic modalities are also carefully covered. Special attention is paid to differential diagnosis of malignant and benign lesions, and the most important benign breast diseases are described and illustrated with high-quality images. A special chapter analyzes treatment strategy in men with breast malignancies and principles of follow-up after breast surgery. Individual chapters are also devoted to the diagnosis of recurrent cancer and cancer metastases. This up-to-date and richly illustrated book will interest and assist specialists in ultrasound diagnostics, radiologists, oncologists, and surgeons.
  • 2001 CRCnetBASE
    Ronot, Xavier; Usson, Yves.
  • 2005 Springer
    De Vuyst, P.; Gevenois, P. A.
    Also available: Print – 2005
  • 2006 Springer
    Müller-Forell, W. S.
    General Part -- 1 Ophthalmologic imaging methods / Wolfgang E. Lieb, Wibke S. Müller-Forell, Werner Wichman -- 1.1 Color Doppler ultrasonography of the eye and orbit / Wolfgang Lieb -- 1.2 Computed tomography / Wibke S. Müller-Forell -- 1.3 Magnetic resonance imaging (MRI) Werner Wichmann -- 2 Anatomy / Werner Wichmann and Wibke S. Müller-Forell -- 3 Neuro-ophthalmology: a short primer / Urs Schwarz -- 4 Functional magnetic resonance imaging of the human visual system / Spyros S. Kollias -- Special part 5 Optic pathway pathology in children / Eugen Boltshauser and Ernst Martin -- 6 Orbital pathology / Wibke S. Müller-Forell and Susanne Pitz -- 7 Intracranial pathology of the optic pathway / Wibke S. Müller-Forell -- Subject index -- List of anatomic structures -- List of acronyms -- List of contributors.
  • 2009
    Berquist, Thomas H.
    PrintStatus: Not Checked OutLane Catalog Record
    Imaging techniques -- Common orthopaedic terminology and general fixation devices -- Spinal instrumentation -- The pelvis and hips -- The femoral shaft -- The knee -- Tibial and fibular shafts -- The foot and ankle -- The shoulder -- Humeral shaft fractures -- The elbow -- The radius and ulna -- Hand and wrist -- Musculoskeletal neoplasms.
  • 2007 Springer
    Gielen, J. L.; Maas, M.; Vanhoenacker, F.
  • 2010 ClinicalKey
    Waldman, Steven D.; Campbell, Robert S. D.
    Noted pain management authority Steven D. Waldman, MD, JD, and Robert Campbell, MD, a well-respected radiologist at Royal Liverpool Hospital in the UK, have combined their expertise to bring you Imaging of Pain. This first-of-its-kind reference helps you select the most appropriate imaging studies to evaluate more than 200 pain conditions so you can implement the most effective management approaches. You₂ll gain a clear understanding of how and when to use a given modality for a particular pain disorder, whether it involves bone, soft tissue, or the spinal cord. At expertconsult.com you'll access the complete contents online, fully searchable, with links to Medline and PubMed abstracts, for rapid, easy consultation from any computer. Access the fully searchable text online at expertconsult.com. Get the most definitive guidance available from leading authorities Drs. Waldman and Campbell. Know how and when to use each modality to confirm or deny a diagnosis for more than 200 pain conditions in all body regions. Provide the most effective pain relief by accurately identifying its underlying source. Find the information you need quickly thanks to a consistent, high-yield format.
  • 2007 Springer
    Abd-el Bagi, M. E.; Haddad, Maurice C.; Tamraz, J. C.
  • 2011 Springer
    Caudana, Roberto; Defilippi, Claudio; Martino, Fabio.
  • 2013 Springer
    Maconi, Giovanni; Tonolini, Massimo.
    This practical volume is intended for all radiologists, gastroenterologists, and surgeons who are responsible for, or interested in, the diagnosis and care of patients with diseases of the anal and perianal region. After an introductory section focusing on surgical, MRI, and US anatomy, up-to-date clinical and therapeutic information is provided on the full range of perianal inflammatory conditions, with special attention to Crohn's disease, ulcerative colitis, and sexually transmitted diseases. Physical and surgical examination is carefully discussed, with consideration of limitations, results, clinical needs, and the questions likely to be posed of imaging. The subsequent three sections provide detailed information on the different imaging modalities: transanal and transperineal ultrasound, contrast-enhanced MRI, and CT. Techniques, diagnostic accuracy, common and unusual disease patterns, artifacts, and pitfalls are clearly presented.
  • 2014 Springer
    Albanese, Carlina V.; Faletti, Carlo.
    An increasing percentage of the population has at least one prosthetic joint. Imaging is required for both initial assessment and routine follow-up of the implant, and this book is intended as an informative and up-to-date guide to the subject. After an introductory section covering a range of background topics, the level of information offered by different imaging techniques in presurgical planning and postimplantation assessment is analyzed. The application of imaging to different joints is then carefully explored in chapters devoted to the foot and ankle, hip, knee, shoulder, and elbow, wrist and hand. In addition, two innovative chapters focus on periprosthetic DXA as the gold standard in monitoring implant survival and on the role of drug therapy in helping to ensure the durability of the prosthesis. A central feature of the book is its combination of the clinical and radiological perspectives; it will be of value to radiologists and orthopedic specialists, as well as residents in these disciplines.
  • 2007 Ovid
    Franquet, Tomás; Lee, Kyung Soo; Müller, Nestor Luiz; Silva, C. Isabela S.
    Pulmonary infection: basic concepts -- Bacterial pneumonia -- Pulmonary tuberculosis -- Nontuberculous mycobacterial pulmonary disease -- Viruses, mycoplasma, and chlamydia -- Fungal and parasitic infection -- Acquired immunodeficiency syndrome -- Immunocompromised host.
    Also available: Print – 2007
  • 2014 Springer
    Paolantonio, Pasquale; Dromain, Clarisse.
    The new series A-Z Notes in Radiological Practice and Reporting provides practical guides for residents and general radiologists, organized alphabetically, primarily according to disease or condition. All booklets are designed so as to cover a large spectrum of topics referring to different anatomical regions of interest. Entries typically include a short description of pathological and clinical characteristics, guidance on selection of the most appropriate imaging technique, a schematic review of potential diagnostic clues, and useful tips and tricks. The present booklet, enriched by illustrations and schemes, is devoted to gastrointestinal imaging. Major topics in CT and MR imaging of the small bowel, colon, rectum, and anus are treated concisely in alphabetical order. For each topic a brief review of clinical features and pathology is presented, followed by a short description of imaging technique and an accurate review of imaging findings and signs which are useful in the differential diagnosis of gastrointestinal disease.
  • 2006 Ovid
    Kransdorf, Mark J.; Murphey, Mark D.
    Origin and classification of soft tissue tumors -- Soft tissue tumors in a large referral population: prevalence and distribution of diagnoses by age, sex, and location -- Imaging of soft tissue tumors -- Lipomatous tumors -- Vascular and lymphatic tumors -- Benign fibrous and fibrohistiocytic tumors -- Malignant fibrous and fibrohistiocytic tumors -- Muscle tumors -- Neurogenic lesions -- Synovial tumors -- Extraskeletal osseous and cartilaginous lesions -- Tumors of uncertain histogenesis -- Masses which may mimic soft tissue tumors -- Compartmental anatomy.
    Also available: Print – 2006
  • 2014 Ovid
    Kransdorf, Mark J.; Murphey, Mark D.
    Origin and classification of soft tissue tumors -- Soft tissue tumors in a large referral population: prevalence and distribution of diagnoses by age, sex, and location -- Imaging of soft tissue tumors -- Lipomatous tumors -- Vascular and lymphatic tumors -- Fibrous and fibrohistiocytic tumors -- Muscle tumors -- Neurogenic tumors -- Synovial tumors -- Extraskeletal osseous and cartilagenous tumors -- Tumors of uncertain histogenesis -- Superficial soft tissues masses -- Mass which may mimic soft tissue tumors -- Compartmental anatomy.
  • 2006 Springer
    Schepper, A. M. A. de.
  • 2013 ClinicalKey
    Castillo, Mauricio; Cha, Soonmee; Naidich, Thomas P.; Smirniotopoulos, James G.
    Section 1. Techniques for imaging -- section 2. Image and pattern analysis -- section 3. Scalp, skull, and meninges -- section 4. Normal brain anatomy -- section 5. Cerebrovascular anatomy and disease -- section 6. Craniocerebral trauma -- section 7. Cysts and tumors -- section 8. The phakomatoses -- section 9. Infection and inflammation -- section 10. Aging and degeneration -- section 11. Toxic and metabolic conditions -- section 12. Hydrocephalus -- section 13. Epilepsy.
  • 2013 Springer
    Swischuk, Leonard E.
    Developmental Anatomy -- Normal Variations -- Anomalies -- Anomalies and Normal Variations of the Dens -- Trauma -- Miscellaneous Cervical Spine Problems.
  • v.1-2=, 2008 ClinicalKey
    Müller, Nestor Luiz; Silva, C. Isabela S.
    Normal Chest Radiograph -- Normal Computed Tomography of the Chest -- Ultrastructure of the Pulmonary Parenchyma -- Consolidation -- Atelectasis -- Nodules and Masses -- Interstitial Patterns -- Decreased Lung Density -- Airway and Parenchymal Anomalies -- Congenital Malformations of the Pulmonary Vessels in Adults -- Community-Acquired Pneumonia -- Bacterial Pneumonia -- Pulmonary Tuberculosis -- Nontuberculous (Atypical) Mycobacterial Infection -- Fungal Infections -- Mycoplasma pneumoniae -- Chlamydia -- Viruses -- Parasites -- Acquired Immunodeficiency Syndrome (AIDS) -- Immunocompromised Host (Non-AIDS) -- Lung Cancer: Overview and Classification -- Screening for Lung Cancer -- Lung Cancer: Radiologic Manifestations and Diagnosis -- Pulmonary Carcinoma: Staging -- Carcinoid Tumors, Pulmonary Tumorlets, and Neuroendocrine Hyperplasia -- Neoplasms of Tracheobronchial Glands -- Pulmonary Hamartoma -- Inflammatory Pseudotumor -- Pulmonary Metastases -- Pulmonary Lymphoid Hyperplasia and Lymphoid Interstitial Pneumonia (Lymphocytic Interstitial Pneumonia) -- Non-Hodgkin's Lymphoma -- Hodgkin's Disease -- Idiopathic Pulmonary Fibrosis -- Nonspecific Interstitial Pneumonia -- Cryptogenic Organizing Pneumonia (Bronchiolitis Obliterans Organizing Pneumonia) -- Acute Interstitial Pneumonia -- Sarcoidosis -- Hypersensitivity Pneumonitis -- Pulmonary Langerhans Cell Histiocytosis -- Smoking-Related Interstitial Lung Disease Respiratory Bronchiolitis and Respiratory Bronchiolitis-Associated Interstitial Lung Disease -- Lymphangioleiomyomatosis and Tuberous Sclerosis -- Rheumatoid Arthritis -- Systemic Sclerosis (Scleroderma) -- Systemic Lupus Erythematosus -- Polymyositis/ Dermatomyositis -- Sjögren's Syndrome -- Mixed Connective Tissue Disease -- Relapsing Polychondritis -- Wegener Granulomatosis -- Churg-Strauss Syndrome -- Goodpasture Syndrome (Anti-Basement Membrane Antibody Disease) -- Microscopic Polyangiitis -- Behçet's Disease -- Takayasu Arteritis -- Simple Pulmonary Eosinophilia (Löffler Syndrome) -- Chronic Eosinophilic Pneumonia -- Acute Eosinophilic Pneumonia and Hypereosinophilic Syndrome -- Metabolic and Storage Lung Diseases -- Acute Pulmonary Embolism -- Chronic Pulmonary Thromboembolism -- Nonthrombotic Pulmonary Embolism -- Pulmonary Arterial Hypertension -- Permeability Pulmonary Edema -- Hydrostatic Pulmonary Edema -- Tracheal Abnormalities: Tracheal Stenosis -- Tracheal Abnormalities: Tracheal Neoplasms -- Tracheal Abnormalities: Tracheomalacia -- Tracheal Abnormalities: Relapsing Polychondritis -- Tracheal Abnormalities: Tracheomegaly -- Tracheal Abnormalities: Tracheobronchopathia Osteochondroplastica -- Bronchial Abnormalities -- Specific Causes of Bronchiectasis -- Asthma -- Bronchiolitis -- Emphysema -- Silicosis and Coal Workers' Pneumoconiosis -- Asbestos-Related Disease -- Uncommon Pneumoconioses -- Aspiration -- Drug-Induced Lung Disease -- Radiation-Induced Lung Disease -- Blunt Thoracic Trauma -- Postoperative Complications -- Chest Radiography in the Intensive Care Unit -- Pneumothorax -- Pleural Effusion -- Benign Pleural Thickening -- Pleural Neoplasms -- Pneumomediastinum -- Mediastinitis -- Anterior Mediastinal Masses -- Middle and Posterior Mediastinal Masses -- Paravertebral Masses -- Diaphragm -- Chest Wall.
  • 2011
    Berquist, Thomas H.
    PrintStatus: Not Checked OutLane Catalog Record
    "Revised and updated for its Third Edition, this highly acclaimed volume is a definitive guide to the clinical imaging of foot and ankle disorders. The title of this edition has changed from Radiology of the Foot and Ankle to Imaging of the Foot and Ankle to reflect a greater emphasis on multimodality imaging approaches to solve diagnostic challenges, specifically the increased use of ultrasound, MR imaging, CT, and diagnostic interventional techniques. The book features increased coverage of ultrasound, PET, and the diabetic foot and upgraded MR and CT images. New syndromes such as impingement have been added to the chapter on soft tissue trauma and overuse. The fractures and dislocations chapter includes OTA classifications and additional MR and CT scans of complications. Other highlights include up-to-date information on new fixation devices and prostheses and state-of-the-art interventional and vascular techniques including use of MRA. This book provides a comprehensive reference for radiologists, radiologists in training, and clinicians who treat foot and ankle disorders including podiatrists, orthopaedic surgeons, rheumatologists, and emergency room physicians"--Provided by publisher.
  • 2013 Springer
    Davies, A. M.; Grainger, Andrew J.; James, S. L. J.
  • 2005 Thieme Book
    Mafee, Mahmood F.; Becker, M.; Valvassori, Galdino E.
    More than 3,700 illustrations and systematic coverage of the latest technical developments make the new edition of Valvassori's text a complete guide to head and neck imaging. Fully revised and updated to include a wider range findings in both adults and children, the book provides in-depth discussions of the eye and orbit, lacrimal drainage system, skull base, mandible and maxilla, temporomandibular joint, and suprahyroid and infrahyroid neck. CT and MRI scans acquired with the most advanced high-resolution equipment show all anatomic structures and pathological conditions, with actual cases clarifying every concept. With thorough coverage of the newest imaging modalities, an abundance of high-quality graphics, and the expertise of worldwide leaders in the field, this is the reference of choice on head and neck imaging for experienced practitioners and residents-in-training.
  • 2006 Springer
    Davies, A. M.; Johnson, K.; Whitehouse, Richard W.
  • 2014 ScienceDirect
    Madras, Bertha; Seeman, Philip.
    "Modern imaging techniques have allowed researchers to non-invasively peer into the human brain and investigate, among many other things, the acute effects and long-term consequences of drug abuse. Here, we review the most commonly used and some emerging imaging techniques in addiction research, explain how the various techniques generate their characteristic images and describe the rational that researchers use to interpret them. In addition, examples of seminal imaging findings are highlighted that illustrate the contribution of each imaging modality to the expansion in our understanding of the neurobiological bases of drug abuse and addiction, and how they can be parlayed in the future into clinical and therapeutic applications"--Provided by publisher.
  • 2009 Springer
    Armatura, Giulia; Balthazar, Emil J.; Megibow, Alec J.; Mucelli, Roberto Pozzi.
    Part 1. Acute Pancreatitis -- Pathophysiology of Acute Pancreatitis / Peter Shamamian, Peter Kingman, John Mallen-St. Clair and Dafna Bar-Sagi -- Clinical Aspects of Acute Pancreatitis: Features, Prognosis and Use of Imaging Findings in Therapeutic Decision Making / Richard S. Kwon, Koenraad J. Mortele and Peter A. Banks -- The Role of Ultrasound in Acute Pancreatitis / Costanza Bruno, Salvatore Minniti and Giacomo Schenal -- The Role of Computed Tomography / Emil J. Balthazar -- Magnetic Resonance Imaging of Acute Pancreatitis / Elizabeth Hecht -- Part 2. Pancreatic Trauma -- Pancreatic Trauma / Alec J. Megibow -- Part 3. Chronic Pancreatitis -- Pathophysiology of Chronic Pancreatitis / Giorgio Cavallini and Luca Frulloni -- Clinical Aspects of Chronic Pancreatitis: Features and Prognosis / Luca Frulloni and Giorgio Cavallini -- The Role of Ultrasound / Mirko D'Onofrio -- The Role of Computed Tomography / Rossella Graziani, Daniela Cenzi, Francesca Franzoso, Daniela Coser and Marinella Neri -- The Role of MR Imaging in Chronic Pancreatitis / Lorenzo Cereser, Maria Antonietta Bali, Myriam Delhaye and Celso Matos -- The Role of Endoscopic Retrograde Cholangiopancreatography (ERCP) / Myriam Delhaye -- Part 4. Complications of Acute and Chronic Pancreatitis -- Pathology of Chronic Pancreatitis / Giuseppe Zamboni, Paola Capelli and Günter Klöppel -- Clinical Aspect of Complications: Features and Prognoses / Claudio Bassi, Giovanni Butturini, Nora Sartori, Massimo Falconi and Paolo Pederzoli -- Imaging of Pancreatic Pseudocyst / Giovanni Carbognin, Carlo Biasiutti, Chiara Calciolari, Giovanni Foti and Roberto Pozzi Mucelli -- Imaging of Biliary and Vascular Complications / Giancarlo Mansueto, Daniela Cenzi, Giulia Armatura, Riccardo Sante Murano and Alessia Tognolini -- Imaging of Local Extension and Fistulas / Giovanni Carbognin, Chiara Calciolari and Giovanni Foti -- Chronic Pancreatitis vs Pancreatic Tumors / Alessandro Guarise, Niccolò Faccioli, Giovanni Morana and Alec J. Megibow -- The Role of Endoscopy in Acute and Chronic Pancreatitis / David L. Diehl -- Surgical and Interventional Perspective in Chronic Pancreatitis / Massimo Falconi, Letizia Boninsegna, Nora Sartori, Claudio Bassi and Paolo Pederzoli.
  • 2005 Springer
    Davies, A. M.; Hodler, Jürg.
  • 2011 ClinicalKey
    Naidich, Thomas P.
    pt. 1. Introduction -- pt. 2. Paraspinal structures -- pt. 3. Normal spinal column and cord -- pt. 4. Normal spinal aging and degeneration -- pt. 5. Normal vascularization and ischemia -- pt. 6. Spinal trauma -- pt. 7. Spinal vascular malformations -- pt. 8. Spinal cysts and tumors -- pt. 9. Metabolic conditions -- pt. 10. Spinal infection -- pt. 11. Spinal inflammation -- pt. 12. Operative considerations -- pt. 13. The brachial and sacral plexuses.
  • 2007 Springer
    Jurik, Anne Grethe.
  • 2009 Thieme Book
    Loevner, Laurie A.; Swartz, Joel D.
    Temporal bone imaging technique -- The external auditory canal and pinna -- The middle ear and mastoid -- Temporal bone vascular anatomy, anomalies, and disease, with an emphasis on pulsatile tinnitus -- The inner ear and otodystrophies -- Temporal bone trauma -- Anatomy and development of the facial nerve -- The vestibulocochlear nerve, with an emphasis on the normal and diseased internal auditory canal and cerebellopontine angle.
    Also available: Print – 2009
  • 2014 Springer
    Tonolini, Massimo.
    During the past decade, the medical and surgical treatment of ulcerative colitis has undergone dramatic advances, including the widespread use of immunomodulators, biological drugs, and restorative proctocolectomy. In order to correctly balance the risks and benefits of medical therapies and surgical procedures, there is a need for improved diagnosis of colonic disease, acute complications, extraintestinal manifestations, and early and delayed postoperative complications. Cross-sectional imaging techniques are therefore playing an increasing role in the assessment of ulcerative colitis and provide an essential complement to clinical data and endoscopy. This practical, illustrated volume on the role of cross-sectional imaging is aimed at radiologists, gastroenterologists, and surgeons who are engaged or interested in the diagnosis and care of patients with inflammatory bowel disease, particularly ulcerative colitis. After an overview of diagnostic imaging techniques, state-of-the-art assessment of colorectal inflammatory disease with CT colonography using water enema and bowel MRI is discussed, followed by description of the plain radiographic and CT findings in patients with acute exacerbations and surgical complications. Subsequent chapters review the diagnostic findings and role of cross-sectional imaging in the assessment of sclerosing cholangitis (with emphasis on MR cholangiopancreatography), vascular complications (particularly portal and mesenteric thrombosis), colitis-associated colorectal cancer and perianal inflammatory disease. Normal postoperative appearances and early and delayed complications in patients treated with proctocolectomy and ileal pouch-anal anastomosis are also comprehensively reviewed.
  • 2014 Springer
    Builov, Vladimir M.
    1. Diagnostics of pelvicalyceal diverticula -- 2. Diagnostics of ureteral diverticula -- Diagnostic Imaging of urinary bladder diverticula -- 4. Urethral diverticula -- Appendix.
  • 2009 Springer
    Grazioli, Luigi; Olivetti, Lucio.
  • 2011 ClinicalKey
    Czervionke, Leo F.; Fenton, Douglas S.
    Section 1. Normal computed tomography and magnetic resonance imaging anatomy -- section 2. Painful spine disorder.
  • 2008 Springer
    DeLancey, John O. L.; Stoker, J.; Taylor, S. A.
  • 2010 Springer
    Passariello, R.; Simonetti, G.
  • 2014 Springer
    Pollice, Saverio; Scarabino, T.
    This book reviews in detail the role of neuroradiological imaging in the evaluation of patients who have undergone surgery or interventional radiology procedures, and particularly its value in the documentation of normal and pathological post-treatment changes, detection of complications, and follow-up. The opening sections describe pretreatment images in various conditions, including trauma, degenerative disc disease, and osteoporosis, and the different types of neurosurgical and interventional treatment that may be used. The post-treatment appearances of normal sequelae and complications on conventional radiography, CT, and MRI are then documented in detail on the basis of a large series of clinical cases, with a wealth of images. Guidance is provided on selection of one or a combination of imaging modalities. This book will be an invaluable clinical and research tool not only for neuroradiologists but also for neurosurgeons, and interventional radiologists.
  • 2006 Thieme Book
    Maeurer, Juergen.
    Functional anatomy of the knee joint -- Traumatic disorders -- Degenerative diseases -- Inflammatory diseases -- Tumors and tumorlike lesions of the knee joint -- Endocrine/metabolic disorders and crystal-induced diseases -- Ischemic diseases -- Hematologic diseases -- Neuropathic osteoarthropathy -- Pediatric radiology.
  • 2013 Springer
    Casanova, Manuel F.; El-Baz, Ayman S.; Suri, Jasjit S.
    Data compiled by the Center for Disease Control and Prevention indicates an alarming and continuing increase in the prevalence of autism. Despite intensive research during the last few decades, autism remains a behavioral defined syndrome wherein diagnostic criteria lack in construct validity. And, contrary to other conditions like diabetes and hypertension, there are no biomarkers for autism. However, new imaging methods are changing the way we think about autism, bringing us closer to a falsifiable definition for the condition, identifying affected individuals earlier in life, and recognizing different subtypes of autism. The imaging modalities discussed in this book emphasize the power of new technology to uncover important clues about the condition with the hope of developing effective interventions. Imaging the Brain in Autism was created to examine autism from a unique perspective that would emphasize results from different imaging technologies. These techniques show brain abnormalities in a significant percentage of patients, abnormalities that translate into aberrant functioning and significant clinical symptomatology. It is our hope that this newfound understanding will make the field work collaborative and provide a path that minimizes technical impediments.
  • 2010 Springer
    Roe, Anna Wang.
  • 2014 Springer
    Falter, Florian; Screaton, Nicholas J.
    Work in intensive care is dynamic and often requires swift decision-making to achieve the best patient outcome. This book serves as a practical guide for professionals working in this demanding area of medicine. It reviews diagnostic options as well as strengths and weaknesses of imaging techniques in clinical scenarios familiar to most ICU clinicians. The concise format allows rapid access to key information. Imaging the ICU Patient is a true collaboration between critical care and radiology. It demystifies the process of deciding when and how to image the critically ill patient. Using a symptom-orientated approach, it addresses techniques as well as patient safety issues. It is meant to be used by critical care clinicians and radiologists and aims to foster a better appreciation of the concerns both specialties have when imaging critically ill patients.
  • 2015 Springer
    Miele, Vittorio; Trinci, Margherita.
    This book provides a detailed and comprehensive overview of the role of diagnostic imaging in the assessment and management of trauma and polytrauma in children. The coverage includes imaging of injuries to the head, thorax, abdomen, bone and musculoskeletal system, with careful attention to the newest imaging techniques, imaging during the course of recovery, and imaging of complications. A series of illustrative cases underline the prognostic value of imaging. In addition, an individual chapter is devoted to diagnostic imaging in cases of child abuse. The book concludes by discussing informed consent and medicolegal issues related to the imaging of pediatric traumatic emergencies. Imaging Trauma and Polytrauma in Pediatric Patients will be invaluable in enabling radiologists and clinicians to identify the main features and signs of injuries on a wide range of imaging techniques, including X-ray, ultrasonography, computed tomography, and magnetic resonance imaging.
  • 2010 ebrary
    Serlin, David.
    From seventeenth-century broadsides about the handling of dead bodies, printed during London's plague years, to YouTube videos about preventing the transmission of STDs, public health advocacy and education has always had a powerful visual component. Imagining Illness explores the diverse visual culture of public health, broadly defined, from the nineteenth century to the present. Contributors to this volume examine historical and contemporary visual practices-Chinese health fairs, documentary films produced by the World Health Organization, illness maps, fashions for nurses, and live surgery.
  • v. 1-2, 2011.
    PrintStatus: Not Checked OutLane Catalog Record
    v.1 : 1. Introduction, assumptions, and principles of this manual -- 2. Quick Check and emergency treatments -- 3. Approach to the severly ill patient (after the Quick Check) -- 4. Trauma: approach to the acutely injured patient -- 5. Approach to laboratory investigations -- 6. Infection prevention and control -- 7. Procedures -- 8. Medicines/therapies -- v.2 : 9. HIV diagnosis -- 10. Acute and subacute by sympton -- 11. Multisystem communicable diseases, renal and HIV-related cancers (in alphabetical order) -- 12. Chronic and long-term care -- 13. Chronic HIV care, antiretroviral therapy (ART), and prevention -- 14. PMTCT, HIV prevention, care and treatment during pregnancy, and family planning -- 15. Tuberculosis -- 16. Assessment and therapy for alcohol use disorders -- 17. Substance use -- 18. General principles of geriatric care -- 19. Prevention services for adolescents, adults and health workers -- 20. Palliative care: sympton management and end-of-life care -- 21. Patient monitoring and reporting including reporting outbreaks and pharmacovigilance.
  • 2002 ScienceDirect
    Kaczmarek, L.; Robertson, Harold A.
    Also available: Print – 2002
  • 2006 Springer
    Pinaud, Raphael; Tremere, Liisa A.
    Also available: Print – 2006
  • 2006 Springer Protocols
    Guisan, Jose M.
  • 2013 Springer Protocols
    Guisan, Jose M.
    New opportunities for immobilization of enzymes / Jose M. Guisan -- Immobilization of enzymes : a literature survey / Beatriz Brena, Paula González-Pombo, and Francisco Batista-Viera -- Glutaraldehyde-mediated protein immobilization / Fernando López-Gallego, Jose M. Guisán, and Lorena Betancor -- Immobilization of enzymes on monofunctional and heterofunctional epoxy-activated supports / Cesar Mateo, Valeria Grazu, and Jose M. Guisan -- Stabilization of enzymes by multipoint covalent immobilization on supports activated with glyoxyl groups / Fernando López-Gallego ... [et al.] -- Oriented covalent immobilization of enzymes on heterofunctional-glyoxyl supports / Cesar Mateo ... [et al.] -- Reversible covalent immobilization of enzymes via disulfide bonds / Karen Ovsejevi, Carmen Manta, and Francisco Batista-Viera -- Immobilization of Candida rugosa lipase on superparamagnetic Fe3O4 nanoparticles for biocatalysis in low-water media / Joyeeta Mukherjee, Kusum Solanki, and Munishwar Nath Gupta -- Immobilization of enzymes by bioaffinity layering / Veena Singh, Meryam Sardar, and Munishwar Nath Gupta -- Immobilization of enzymes on magnetic beads through affinity interactions / Audrey Sassolas, Akhtar Hayat, and Jean-Louis Marty -- Tips for the functionalization of nanoparticles with antibodies / Ester Polo ... [et al.] -- Design and characterization of functional nanoparticles for enhanced bio-performance / Pablo del Pino, Scott G. Mitchell, and Beatriz Pelaz -- Immobilization of enzymes on ethynyl-modified electrodes via click chemistry / Akhtar Hayat ... [et al.] -- Modification of carbon nanotube electrodes with 1-pyrenebutanoic acid, succinimidyl ester for enhanced bioelectrocatalysis / Guinevere Strack ... [et al.] -- Enzyme immobilization by entrapment within a gel network / Audrey Sassolas, Akhtar Hayat, and Jean-Louis Marty -- Practical protocols for lipase immobilization via sol-gel techniques / Manfred T. Reetz -- Improving lipase activity by immobilization and post-immobilization strategies / Jose M. Palomo ... [et al.] -- High activity preparations of lipases and proteases for catalysis in low water containing organic solvents and ionic liquids / Ipsita Roy ... [et al.] -- Biomedical applications of immobilized enzymes : an update / Marta Pastor, Amaia Esquisabel, and José Luis Pedraz -- Immobilization of whole cells by chemical vapor deposition of silica / Susan R. Sizemore ... [et al.] -- Encapsulation of cells in alginate gels / Pello Sánchez ... [et al.] -- Microalgal immobilization methods / Ignacio Moreno-Garrido -- Therapeutic applications of encapsulated cells / Argia Acarregui ... [et al.] -- Whole cell entrapment techniques / Jorge A. Trelles and Cintia W. Rivero.
  • ScienceDirect
    Mosbach, Klaus.
    Also available: Print – 1987
  • ScienceDirect
    Mosbach, Klaus.
    Also available: Print – 1987
  • ScienceDirect
    Mosbach, Klaus.
    Also available: Print – 1988
  • 2009
    Skloot, Rebecca.
    PrintStatus: Not Checked OutLane Catalog Record
    Her name was Henrietta Lacks, but scientists know her as HeLa. She was a poor Southern tobacco farmer, yet her cells--taken without her knowledge--became one of the most important tools in medicine. The first "immortal" human cells grown in culture, they are still alive today, though she has been dead for more than sixty years. HeLa cells were vital for developing the polio vaccine; uncovered secrets of cancer and viruses; helped lead to in vitro fertilization, cloning, and gene mapping; and have been bought and sold by the billions. Yet Henrietta Lacks is buried in an unmarked grave. Her family did not learn of her "immortality" until more than twenty years after her death, when scientists began using her husband and children in research without informed consent. The story of the Lacks family is inextricably connected to the dark history of experimentation on African Americans, the birth of bioethics, and the legal battles over whether we control the stuff we are made of--From publisher description.
  • 2011
    Vasey, Adrianne Elizabeth; Chawla, Ajay; Engleman, Edgar G.; Negrin, Robert S.; Utz, Paul J.
    Allogeneic hematopoietic cell transplantation (HCT) is an excellent model for the controlled study of adoptively transferred cells in the induction and progression of numerous immune responses in vivo, with the added benefit that these cells can be tracked, identified, and re-isolated. Using this model, we conducted four distinct sets of studies related to the trafficking and function of immune cells in allogeneic responses. In our first project, we focused on the early events of T cell activation leading to the induction of Graft-versus-Host Diesease (GVHD) in a murine model of major histocompatibility complex (MHC)-matched transplantation. Although it is well known GVHD occurs in MHC-matched transplants, little is known about donor T cell activation kinetics in minor-mismatched models. Yet, because these models better approximate clinical transplantation, it is critical to understand how GVHD develops across minor barriers. To investigate temporal and spatial events of GHVD development, side-by-side transplants were conducted into major and minor-mismatched recipients using hematopoietic cells from the same donor mouse strain. In both models, T cells home to nodal sites by day 3, proliferate, and exit to GVHD target tissues by day 6. Additionally, expression of homing and activation markers was equivalent for all markers examined on day 3. However, tissue migration and proliferation were reduced in the minor model. And by day 6, minor-mismatched T cells had increased CD62L retention and reduced P-selectin and CD44 expression. We also found fewer MHC-matched T cells producing interferon-[gamma] (IFN-[gamma]) and tumor necrosis factor-[alpha] (TNF-[alpha]). Our data show that very early events of donor T cell activation are similar in both models, suggesting that delays in GVHD onset across minor barriers arise from temporal differences in the effector phase, rather than the initiation phase, of GVHD. For our second project, we examined the ability of transplanted natural killer (NK) cells to impact GVHD in MHC-matched transplants as allogeneic NK cells are already known to suppress GVHD in transplants across major histocompatibility barriers. Since NK cells can lyse host antigen-presenting cells (APCs) in these transplants due to disparities in MHC class I expression between the recipient and donor, thus reducing the activation of donor T cells, it is thought that this is primary mechanism of NK-mediated reductions in GVHD. However, in MHC-matched transplants, MHC class I expression is shared between donor and host, protecting host APCs from lysis. Previous work from our laboratory has shown that NK cells can also reduce GVHD, in MHC-mismatched transplants, through the inhibition and lysis of autologous donor T cells that have upregulated expression of NKG2D activating ligands. As such, we wondered whether this mechanism may also reduce GVHD in transplants across minor histocompatibility barriers. Our data demonstrate that donor NK cells are able to improve survival and reduce GHVD disease severity in the more clinically relevant model of MHC-matched transplantation. As allorecognition and lysis of MHC-mismatched host APCs is not possible in this model, NK cells must be mediating their benefits through alternate mechanisms. Although we did find that NK cells were capable of reducing the proliferation of syngeneic T cells in an MLR using irradiated MHC-matched splenocytes as stimulators, we were unable to find evidence for the direct inhibition, or lysis, of donor T cells by NK cells in vivo. It seems likely that this was at least partially due to the much lower number of NK cells used in these studies compared to the previous reports. Additionally, as NK cells may impact T cells that are homeostatically proliferating differently then they impact T cells proliferating in response to antigen, it will be critical for future studies to clearly separate these two populations, especially given the reduced frequency of alloreactive T cells in MHC-matched models. Perhaps then we will be able to identify the mechanisms of donor NK mediated reductions in GVHD. In our third project, we studied the in vivo ability of NK cells to clear tumor. NK cells have natural cytotoxicity and cytokine production capabilities, and are known to mount potent responses against both viruses and tumor cells. Preclinical data in combination with results from clinical trials of haploidentical killer immunoglobulin-like receptor (KIR)-ligand mismatched bone marrow transplantation led to interest in the use of adoptive NK immunotherapy for the treatment of malignancy. Recent early-phase clinical trial results have shown that allogeneic NK cells can be safely administered after chemotherapy and/or irradiation but have also demonstrated limited persistence of the infused NK cells. Additionally, in the absence of control arms, it has been difficult to determine whether tumor clearance is due to the preparative regimen, or due to actual immune mediated effects. Here, using several murine models of NK-sensitive hematologic malignancy, we trace the fate of adoptively infused NK cells and show that NK cells traffic to tumor sites but fail to control tumor growth. NK cells rapidly down-regulate effector functions and activating receptor expression upon homeostatic proliferation and upon tumor exposure in syngeneic as well as allogeneic settings. This dysfunction is likely cell-intrinsic as it is accompanied by down-regulation of the canonical transcription factors Eomesodermin and T-bet, and is not impacted by depletion of regulatory T cells from the tumor milieu. These results demonstrate that NK cell capability is intrinsically limited and cannot be relied upon for adoptive anti-tumor immunotherapy. As such, novel approaches may be required in order to circumvent the described dysfunction phenotype. Lastly, we attempted to deplete dendritic cells (DCs) within the host to study impacts on the development of GVHD. To try to delineate whether there is a critical time window during which host DCs cells need to initiate GVHD, we conducted MHC-mismatched transplants into BALB/c mice that were chimeric for the CD11c DTR-GFP transgene in their hematopoietic system, to be able to control the deletion of host DCs at specific time points. Despite initial problems with DT lethality in the original transgenic mice, we were able to achieve successful, transient, depletion of host DCs using these chimeric mice made from the BM of transgenic donors. Although we found that DT treatment of transgenic mice 24 hours to harvesting their spleens for use as stimulators in an MLR greatly reduced allogeneic T cell proliferation, DT treatment of transgenic chimeric recipients prior to irradiation and transplantation with allogeneic T cells did not provide any protection from the development of GVHD, even with up to a 4 day delay in T cell administration and titrating T cell doses down to 1 x 105. In contrast, DT treated mice actually had reduced survival compared to transgenic chimeras given only PBS, suggesting that DC depletion may somehow enhance T cell proliferation. This may be partially due to negative impacts on the activation, expansion, and function of Tregs, which are known to have important cross-talk with DCs. These studies were further complicated by the fact that the chimeric transgenic mice had all previously undergone lethal TBI, as we found that previously irradiated recipients had reduced survival when transplanted with allogeneic T cells, regardless of whether or not they were transgenic of WT or whether they received DT or PBS, compared to mice that had never been irradiated previously. Additionally, since DC depletion is not 100% in these animals, we were unable to precisely determine the contribution of remaining cell types in the outcomes we observed. As such we were unable to conclude anything about the role of host DCs in the development of GVHD from these studies.
  • 2013 Springer Protocols
    Lenardo, Michael; Snow, Andrew L.
    Quantitating lymphocyte programmed cell death in vitro using simple kill assays / Lixin Zheng -- Fluorescence-activated cell sorting-based quantitation of T cell receptor restimulation-induced cell death in activated, primary human T cells / Gil Katz and Andrew L. Snow -- Evaluation of IL-2-withdrawal-induced apoptosis in human T lymphocytes / Joao Bosco Oliveira -- Determination of apoptosis sensitivity in specific T cell subsets from human peripheral blood by utilizing a multiparameter fluorescence-activated cell sorting-based technique / Bernice Lo and Madhu Ramaswamy -- Visualization of fas-mediated death-inducing signaling complex formation by immunoprecipitation / Nelia Cordeiro and Nicolas Bidere -- Analyses of programmed cell death in dendritic cells / Min Chen, Lily Huang, and Jin Wang -- Detection of necrosis by release of lactate dehydrogenase Activity / Francis Ka-Ming Chan, Kenta Moriwaki, and Maria Jose De Rosa -- Assessment of CD4+ and CD8+ T cell responses using MHC class I and II tetramers / Sema Kurtulus and David Hildeman -- Homeostatic proliferation of mature T cells / Christopher E. Martin [and others] -- Quantitating lymphocyte homeostasis in vivo in humans using stable isotope tracers / Liset Westera [and others] -- Real-time quantitative (RQ- )PCR approach to quantify the contribution of proliferation to B lymphocyte homeostasis / Menno C. van Zelm [and others] -- Molecular measurement of T cell receptor excision circles / Heather E. Lynch and Gregory D. Sempowski -- Isolation of RNA and the synthesis and amplification of cDNA from antigen-specific T cells for genome-wide expression analysis / R. Anthony Barnitz [and others] -- Designs for massively parallel sequencing approaches to identify causal mutations in human immune disorders / Yu Zhang and Helen C. Su -- Flow cytometric measurement of SLAM-associated protein and x-linked inhibitor of apoptosis / Rebecca A. Marsh, Jack J. Bleesing, and Alexandra H. Filipovich -- In vitro suppression assay for functional assessment of human regulatory T cells / Dat Q. Tran.
  • 2009 Springer
    Krause, Walter; Naz, Rajesh K.
  • 2006 Springer
    Blumberg, R. S.; Neurath, M.
    Structure and function of the gut mucosal immune system / Reinhard Pabst and Hermann J. Rothkutter -- Functional aspects of the mucosal immune system / Cathryn Nagler-Anderson -- Recent progress in inflammatory bowel disease genetics / Judy H. Cho -- Microbial and dietary factors in the pathogenesis of chronic, immune-mediated intestinal inflammation / R. Balfour Sartor -- Experimental models of mucosal inflammation / Warren Strober and Ivan J. Fuss -- Overview of role of the immune system in the pathogenesis of inflammatory bowel disease / Thomas T. MacDonald and Giovanni Monteleone -- The role of the epithelial barrier in inflammatory bowel disease / Edward E.S. Nieuwenhuis and Richard S. Blumberg -- Involvement of dendritic cells in the pathogenesis of inflammatory bowel disease / Francisco Leon ... [et al.] -- Alterations of T lymphocytes in inflammatory bowel diseases / Charles O. Elson, Yingzi Cong and Casey T. Weaver -- The B-cell system in inflammatory bowel disease / Per Brandtzaeg, Hege S. Carlsen and Trond S. Halstensen -- Alterations of mesenchymal and endothelial cells in inflammatory bowel diseases / Claudio Fiocchi ... [et al.] -- Role of mast cells and eosinophils in neuroimmune interactions regulating mucosal inflammation in inflammatory bowel disease / Stephan C. Bischoff and Thomas Gebhardt -- Multiparameter analysis of immunogenetic mechanisms in clinical diagnosis and management of inflammatory bowel disease / Jonathan Braun and Stephan R. Targan -- The role of probiotics and antibiotics in regulating mucosal inflammation / Rainer Duchmann -- From immunogenic mechanisms to novel therapeutic approaches in inflammatory bowel disease / Martin H. Holtmann and Markus F. Neurath.
    Also available: Print – 2006
  • 2014 Springer
    Pleyer, Uwe.
    These guidelines, compiled by a panel of clinicians and scientists with a high level of expertise, aim to provide readers with the most up-to-date and comprehensive instructions on the treatment and prevention of ocular inflammation. All of the recommendations are explicitly linked to supporting evidence and graded according to the strength of that evidence, and the editors have made every effort to ensure that chapters are of a consistently high methodological quality. The guidelines for each treatment include dose and the frequency and mode of delivery. Significant side-effects of treatment are identified and distinguished from those of the disease in question. Suggestions are presented for the prevention both of the disease itself and of the treatment-related complications. In addition, likely future directions in treatment and prevention are identified. These guidelines will be of great practical value for all clinicians and clinical scientists with an interest in the subject.
  • 2011 Springer Protocols
    Booth, James W. D.; Rast, Jonathan Patrick.
    Screening for ligands of c-type lectin-like receptors / Elwira Pyz and Gordon D. Brown -- Yeast surface display of lamprey variable lymphocyte receptors / Gang Xu, Satoshi Tasumi, and Zeev Pancer -- Identification of scavenger receptor ligands / Claudine Neyen, Annette Pluddemann, and Siamon Gordon -- Construction, expression, and purification of chimeric protein reagents based on immunoglobulin Fc regions / John P. Cannon, Marci O'Driscoll, and Gary W. Litman -- Innate immune receptors for nucleic acids / Andrea Stutz, Damien Bertheloot, and Eicke Latz -- Analysis of receptor-ligand interactions by surface plasmon resonance / Kimiko Kuroki and Katsumi Maenaka -- Cell-based reporter assay to analyze activation of Nod1 and Nod2 / Birte Zurek, Harald Bielig, and Thomas A. Kufer -- Determining FceRI diffusional dynamics via single quantum dot tracking / Diane S. Lidke [and others] -- Ratiometric analysis of subcellular recruitment of Fc receptors during phagocytosis / Patricia Mero and James W.D. Booth -- Assessment of the recycling of the membrane-bound chemokine, CX3CL1 / Sajedabanu Patel, Ilya Mukovozov, and Lisa A. Robinson -- Measuring immune receptor mobility by fluorescence recovery after photobleaching / Kristen Silver and Rene E. Harrison -- Probing the plasma membrane structure of immune cells through the analysis of membrane sheets by electron microscopy / Bjorn F. Lillemeier and Mark M. Davis -- Rapamycin-based inducible translocation systems for studying phagocytosis / Michal Bohdanowicz and Gregory D. Fairn -- Micropatterned ligand arrays to study spatial regulation in Fc receptor signaling / Alexis J. Torres, David Holowka, and Barbara A. Baird -- CELLISA : reporter cell-based immunization and screening of hybridomas specific for cell surface antigens / Peter Chen, Aruz Mesci, and James R. Carlyle -- Use of colloidal silica-beads for the isolation of cell-surface proteins for mass spectrometry-based proteomics / Yunee Kim [and others] -- Transfection-based genomic readout for identifying rare transcriptional splice variants / Larry J. Dishaw [and others] -- Characterizing somatic hypermutation and gene conversion in the chicken DT40 cell system / Nagarama Kothapalli and Sebastian D. Fugmann -- Characterizing immune receptors from new genome sequences / Katherine M. Buckley and Jonathan P. Rast.
  • 2010
    Linderman, Jessica A.; Mellins, Elizabeth; Miklos, David; Robinson, William H.; Shizuru, Judith A.; Weissman, Irving L.
    Infections resulting from poor immunity remain a major complication after hematopoietic cell transplantation (HCT) and this thesis focuses on two main aspects of immune reconstitution post-HCT. First, the role of adoptively transferred mature donor cells in supplementing immunity is addressed. We report that, while animals receiving whole bone marrow transplants have higher levels of immune cells in the blood and no overt manifestations of clinical illness, there is reduced lymph node cellularity after allogeneic transplantation, destruction of lymph node architecture after fully MHC-disparate transplant and poor proliferative responses to a novel antigen. We conclude that the problems associated with subclinical graft-versus-host disease outweigh any benefits of adoptive transfer of mature cells in this setting. The second main area of investigation focuses on the ability of T cells to provide help to donor B cells and induce antibody production to T-dependent antigens after purified hematopoietic stem cell transplant (HSCT). We report that antibody production to a T-dependent antigen is limited to host B cells in fully MHC-disparate chimeras until 12 weeks post-transplant. In contrast, donor and host-derived B cells produce antibody to a T-independent antigen at six weeks in all chimeras studied and to a T-dependent antigen in MHC-matched and haploidentical chimeras where donor and host share an MHC allele. This delayed reconstitution of cells able to provide help to B cells presenting only donor MHC occurs despite the functional development of donor-derived T-Follicular Helper cells, the subset of T cells believed to provide B cell help, at 6 weeks post-HSCT. These data suggest that reconstitution of donor-restricted T cell function may be delayed in fully MHC-disparate hematopoietic chimeras. However, functional donor-restricted responses do eventually develop in the absence of any graft-versus-host disease. We believe that these findings provide important insights into immune reconstitution after MHC-disparate HSCT, and suggest that graft-versus-host disease rather than MHC-disparity may be the major obstacle to immune function after HCT. This work also provides important insights into the function and development of T-Follicular Helper cells.
  • 2007 Springer
    Zhang, Jingwu.
  • 2006 ScienceDirect
    Mak, Tak W.; Saunders, Mary E.
  • 2007 Karger
    Also available: Print – 2007
  • 2015 Springer
    Ekdahl, Kristina N.; Lambris, J. D.; Nilsson, Bo; Ricklin, Daniel.
    1. Thromboinflammation in therapeutic medicine -- 2. Complement interactions with blood cells, endothelial cells and microvesicles in thrombotic and inflammatory conditions -- 3. Role of complement on broken surfaces after trauma -- 4. Complement involvement in periodontitis: molecular mechanisms and rational therapeutic approaches -- 5. The lectin pathway of complement and biocompatibility -- 6. Foreign body reaction to subcutaneous implants -- 7. Molecular characterization of macrophage-biomaterial interactions -- 8. Heparan sulfate proteoglycan metabolism and the fate of grafted tissues -- 9. Xenotransplantation of cells, tissues, organs and the Greman research foundation Transregio Collaborative Research Centre 127 -- 10. Macroencapsulated pig islets correct induced diabetes in primates up to 6 months -- 11. Regulation of instant blood mediated inflammatory reaction (IBMIR) in pancreatic islet xeno-transplantation: points for therapeutic interventions -- 12. Cell surface engineering for reguation of immune reactions in cell therapy -- 13. Complement interception across humoral incompatibility in solid organ transplantation: a clinical perspective -- Index.
    Also available: Print – 2015
  • 2008 Springer
    Graca, Luis.
    Also available: Print – 2008
  • Parham, P.
    PrintStatus: Not Checked OutLane Catalog Record
  • 2009
    Parham, P.; Janeway, Charles.
    PrintStatus: Not Checked OutLane Catalog Record
    Elements of the immune system and their roles in defense -- Innate immunity -- Principles of adaptive immunity -- Antibody structure and the generation of B-cell diversity -- Antigen recognition by T lymphocytes -- The development of B lymphocytes -- The development of T lymphocytes -- T cell-mediated immunity -- Immunity mediated by B cells and antibodies -- The body's defenses against infection -- Failures of the body's defenses -- Over-reactions of the immune system -- Disruption of healthy tissue by the immune response -- Vaccination to prevent infectious disease -- Transplantation of tissues and organs -- Cancer and its interactions with the immune system.
  • 2011 CRCnetBASE
    Alexander, Michael A.
    Which cells control the anti-cancer T cell immune response? -- Antigen presentation -- T cells and cancer cells : components of immune-based anti-cancer therapy -- Anti-cancer vaccines : new approaches -- How and why do we get cancer and can immune-based anti-cancer therapy save us? -- Immunotherapeutic approaches to the treatment of leukemia -- Cancer-induced autoimmunity -- Can we solve the cancer stem cell program and cure cancer using T cell-based immunotherapy? -- Translational immunology and its impact on anti-cancer T cell immunity and the development of immunotherapeutic treatments for cancer -- Dendritic cells, immunotherapy, and the anti-cancer T cell response -- Regulatory T cells, dendritic cells, and the success of immunotherapeutic treatments for cancer -- NK cells and their role in the development of immune-based anti-cancer therapy -- How cancer cells influence the anti-cancer T cell imune response and why this is a problem during the immunotherapeutic treatment of cancer -- The T cell anti-cancer response, T cell regulation, and immunotherapy of neural crest cancers -- The immunological hole : will we fall in?
  • 2007 Springer
    Shurin, Michael R.; Smolkin, Yuri S.
    Also available: Print – 2007
  • 2009. Karger
    Pourmand, Rahman.
    Acute neuropathies / Bromberg, M.B. -- Chronic neuropathies : chronic inflammatory demyelinating neuropathy and its variants / Ramchandren, S., Lewis, R.A. -- Nonsystemic vasculitic neuropathy : update on diagnosis, classification, pathogenesis, and treatment / Collins, M.P., Periquet-Collins, I. -- Dysimmune neuropathy / Kwan, J.Y. -- Autoimmune autonomic ganglionopathy / Winston, N., Vernino, S. -- Myasthenia gravis with anti-acetylcholine receptor antibodies / Meriggioli, M.N. -- Muscle-specific receptor tyrosine kinase antibody-positive and seronegative myasthenia gravis / Muppidi, S., Wolfe, G.I. -- Lambert-Eaton myasthenic syndrome / Pourmand, R. -- Idiopathic inflammatory myopathies / Dimachkie, M.M., Barohn, R.J. -- Stiff person syndrome / Duddy, M.E., Baker, M.R.
  • 2003 ScienceDirect
    Berczi, Istvan; Szentivanyi, Andor.
  • 2008 Springer
    Vajdy, Michael.
  • 2013 Cold Spring Harb Lab Press
    O'Garra, Anne.
    Development and antigen receptor gene assembly: TET proteins and 5-methylcytosine oxidation in the immune system / Ageliki Tsagaratou, Anjana Rao ; Control of antigen receptor diversity through spatial regulation of V(D)J recombination / Anja Ebert, Jasna Medvedovic, Hiromi Tagoh, Tanja A. Schwickert, Meinrad Busslinger ; Establishment and maintenance of B cell identity / Rudolf Grosschedl ; Transcriptional establishment of cell-type identity : dynamics and causal mechanisms of T-cell lineage commitment / Ellen V. Rothenberg, Ameya Champhekar, Sagar Damle, Marissa Morales Del Real, Hao Yuan Kueh, Long Li, Mary A. Yui ; The epigenetics of early lymphocyte development / C. Murre -- Gene regulation: Regnase-1, a ribonuclease involved in the regulation of immune responses / Shizuo Akira ; Toward an understanding of the gene-specific and global logic of inducible gene transcription / Stephen T. Smale, Scott E. Plevy, Amy S. Weinmann, Liang Zhou, Vladimir R. Ramirez-Carrozzi, Scott D. Pope, Dev M. Bhatt, Ann-Jay Tong ; Tolerization of inflammatory gene expression / John J. Seeley, Sankar Ghosh -- The 'histone mimicry' by pathogens / Uwe Schaefer, Jessica S.Y. Ho, Rab K. Prinjha, Alexander Tarakhovsky -- Development and function of myeloid subsets: Myb-independent macrophages : a family of cells that develops with their tissue of residence and is involved in its homeostasis / Elisa Gomez Perdiguero, Frederic Geissmann ; The molecular choreography of IRF4 and IRF8 with immune system partners / Harinder Singh, Elke Glasmacher, Abraham B. Chang, Bryan Vander Lugt -- The IRF family transcription factors at the interface of innate and adaptive immune responses / Hiroaki Ikushima, Hideo Negishi, Tadatsugu Taniguchi -- T-cell differentiation and function: IL-1b strikingly enhances antigen-driven CD4 and CD8 t-cell responses / S.Z. Ben-Sasson, K. Wang, J. Cohen, W.E. Paul ; A modified model of t-cell differentiation based on mTOR activity and metabolism / Jonathan D. Powell, Emily B. Heikamp, Kristen N. Pollizzi, Adam T. Waickman ; Novel tools to dissect the dynamic regulation of TCR signaling by the kinase Csk and the Phosphatase CD45 / Ying Xim Tan, Julie Zikherman, Arthur Weiss -- NK cells and innate lymphoid cells: Dissection of signaling in inflammation : three novel inflammatory regulators / Thorsten Berger, Mary E. Saunders, Tak W. Mak ; Tissue-resident natural killer cells / Wayne M. Yokoyama, Dorothy K. Sojka, Hui Peng, Zhigang Tian -- Microbial immunity: Immunology taught by human genetics / Jean-Laurent Casanova, Laurent Abel, Lluis Quintana-Murci ; Systems approach to understand the immune response in tuberculosis : an iterative process between mouse models and human disease / Anne O'Garra ; The zebrafish guide to tuberculosis immunity and treatment / Lalita Ramakrishnan ; Microbiota : host interactions in mucosal homeostasis and systemic autoimmunity / Randy S. Longman, Yi Yang, Gretchen E. Diehl, Sangwon V. Kim, Dan R. Littman ; The promised land of human immunology / Laura F. Su, Arnold Han, Helen M. McGuire, David Furman, Evan W. Newell, Mark M. Davis -- Tolerance, TREGS, and inflammasome: Transcriptional control of regulatory t-cell differentiation / Joris van der Veeken, Aaron Arvey, Alexander Rudensky -- miR-181 and metabolic regulation in the immune system / Adam Williams, Jorge Henao-Mejia, Christian C.D. Harman, Richard A. Flavell ; Encoding immunological memory in the initiation of b-cell receptor signaling / Susan K. Pierce, Wanli Liu -- Tumor immunology and genome stability: Programmed cell death 1-directed immunotherapy for enhancing t-cell function / Koichi Araki, Ben Youngblood, Rafi Ahmed ; Immune surveillance of unhealthy cells by natural killer cells / Alexandre Iannello, David H. Raulet ; Studying Epstein-Barr virus pathologies and immune surveillance by reconstructing EBV infection in mice / Tomoharu Yasuda, Tristan Wirtz, Baochun Zhang, Thomas Wunderlich, Marc Schmidt-Supprian, Thomas Sommermann, Klaus Rajewsky -- Closing lecture: Pathogen-sensing, regulatory t cells, and responsiveness-tuning collectively regulate foreign- and self-antigen mediated t-cell responses / William E. Paul, Joshua D. Milner, Zvi Grossman.
  • 2013 Springer
    Malyshev, Igor.
    A General Description of HSPs, The Molecular Structure of HSP70 and The HSP70 Cycle -- The Functions of HSP70 in Normal Cells -- HSP70 in Damaged Cells -- Mechanisms of Activation and Inactivation of HSP70 Synthesis -- HSP70 in the Immune Responses -- HSP70 in Carcinogenesis -- HSP70 in aging -- The role of HSP70 in the protection of: (A) The brain in alzheimer's disease and (B) The heart in cardiac surgery.
  • 2002 NAP
    Almario, Donna A.; McCormick, Marie C.; Stratton, Kathleen R.
  • 2003 NAP
    Almario, Donna A.; McCormick, Marie C.; Stratton, Kathleen R.; Wizemann, Theresa.
  • 2002 NAP
    McCormick, Marie C.; Stratton, Kathleen R.; Wilson, Christopher B.
  • 2003 NAP
    Almario, Donna A.; McCormick, Marie C.; Stratton, Kathleen R.; Wizemann, Theresa.
  • 2013 Springer
    Selvarajoo, Kumar.
    Immuno Systems Biology aims to study the immune system in the more integrated manner on how cells and molecules participate at different system levels to the immune function. Through this book Kumar Selvarajoo introduces to physicists, chemists, computer scientists, biologists and immunologists the idea of an integrated approach to the understanding of mammalian immune system. Geared towards a researcher with limited immunological and computational analytical experience, the book provides a broad overview to the subject and some instruction in basic computational, theoretical and experimental approaches.
  • 2007 CRCnetBASE
    Van Emon, Jeanette M.
    Integrating bioanalytical capability in an environmental analytical laboratory / Jeanette M. Van Emon ... [et al.] -- Directed evolution of ligand-binding proteins / K. Kramer, H. Geue, and B. Hock -- In vitro monoclonal antibody production: academic scale / Frances Weis-Garcia -- Antibodies to heavy metals: isolation, characterization, and incorporation into microplate-based assays and immunosensors / Diane A. Blake ... [et al.] -- Molecular imprinting for small molecules / Z. Cobb and L. I. Andersson -- Aptamer-based bioanalytical methods / Sara Tombelli, Maria Minunni, and Marco Mascini -- Surface imprinting: integration of recognition and transduction / Yanxiu Zhou, Bin Yu, and Kalle Levon -- Phage as biospecific probes / Valery A. Petrenko and Jennifer R. Brigati -- Upconverting phosphors for detection and identification using antibodies / David E. Cooper ... [et al.] -- Mathematical aspects of immunoassays / James F. Brady -- Immunochemical techniques in biological monitoring / Raymond E. Biagini, Cynthia A. F. Strile, and John E. Snawder -- Target and non-targeted approaches for detecting genetically modified organisms / Farid E. Ahmed -- Bioanalytical diagnostic test for measuring prions / Loredana Ingrosso, Maurizio Pocchiari, and Franco Cardone -- Environmental applications of immunoaffinity chromatography / Annette Moser, Mary Anne Nelson, and David S. Hage -- Sol-gel immunoassays and immunoaffinity chromatography / Miriam Altstein and Alisa Bronshtein -- Electrochemical immunoassays and immunosensors / Niina J. Ronkainen-Matsuno, H. Brian Halsall, and William R. Heineman -- Biosensors for environmental monitoring and homeland security / Kanchan A. Joshi, Wilfred Chen, and Ashok Mulchandani -- Bioarrays: current applications and concerns for developing, selecting and using array technology / Joany Jackman -- Microelectrode protein microarrays / Kilian Dill ... [et al.] -- Bioconjugated quantum dots for sensitive and multiplexed immunoassays / Xiaohu Gao ... [et al.] -- Nanotechnology and the future of bioanalytical methods / Lon Porter.
  • NCBI Bookshelf
    Janeway, Charles.
  • 2006 Springer
    Colonna, M.; Vivier, E.
    Also available: Print – 2006
  • 1978-
    Atassi, M. Z.; Stavitsky, Abram Benjamin.
  • ScienceDirect
    Langone, John J.; Van Vunakis, Helen.
    Also available: Print – 1981
  • ScienceDirect
    Langone, John J.; Van Vunakis, Helen.
    Also available: Print – 1981
  • ScienceDirect
    Langone, John J.; Van Vunakis, Helen.
    Also available: Print – 1982
  • ScienceDirect
    Langone, John J.; Van Vunakis, Helen.
    Also available: Print – 1983
  • ScienceDirect
    Langone, John J.; Van Vunakis, Helen.
    Also available: Print – 1983
  • ScienceDirect
    Di Sabato, Giovanni; Langone, John J.; Van Vunakis, Helen.
    Also available: Print – 1984
  • ScienceDirect
    Di Sabato, Giovanni; Langone, John J.; Van Vunakis, Helen.
    Also available: Print – 1985
  • ScienceDirect
    Langone, John J.; Van Vunakis, Helen.
    Also available: Print – 1986
  • ScienceDirect
    Di Sabato, Giovanni; Everse, Johannes.
    Also available: Print – 1986
  • ScienceDirect
    Di Sabato, Giovanni.
    Also available: Print – 1987
  • pt. L-M, 1988. ScienceDirect
    pt. M ScienceDirect
    Di Sabato, Giovanni.
    Also available: Print – pt. L-M, 1988.
  • 2010 Springer
    Burry, Richard W.
  • 2015 Springer Protocols
    Lossi, Laura; Merighi, Adalberto.
    Machine generated contents note: 1.The Evolution of Immunocytochemistry in the Dissection of Neural Complexity / Laura Lossi -- pt. I Immunocytochemistry in Non-Mammalian Brain -- 2.Immunofluorescence and Genetic Fluorescent Labeling Techniques in the Drosophila Nervous System / Christian Wegener -- 3.Immunohistochemical Analysis of Neuronal Networks in the Nervous System of Octopus vulgaris / Graziano Fiorito -- 4.Genetic Mosaic Labeling and Immunofluorescence Techniques in Zebrafish Brain / Yoshihiro Yoshihara -- pt. II Detection of Cell Proliferation and Neurogenesis -- 5.Immunocytochemical Phenotype of Differentiating Neurons / Antonio Carai -- 6.Immunocytochemical Identification of Mammalian Differentiating Neurons in the Process of Adult Neurogenesis in the Hippocampal Dentate Gyrus / Oliver von Bohlen und Halbach -- 7.Identification of Proliferating and Migrating Cells by BrdU and Other Thymidine Analogs: Benefits and Limitations / Pasko Rakic --
  • 2011 Springer
    Eisenbarth, George S.
  • 2010
    Grabenstein, John D.
    PrintStatus: Not Checked OutLane Catalog Record
  • 2008
    Grabenstein, John D.
    PrintStatus: Not Checked OutLane Catalog Record
  • 2006 Springer
    Brassat, David; Oksenberg, Jorge R.
    HLA and autoimmunity : structural basis of immune recognition / Kai W. Wucherpfennig -- Genomic variation and autoimmune disease / Silke Schmidt and Lisa F. Barcellos -- Endocrine diseases : type I diabetes mellitus / Regine Bergholdt, Michael F. McDermott, and Flemming Pociot -- Endocrine diseases : Graves' and Hashimoto's diseases / Yoshiyuki Ban and Yaron Tomer -- Central and peripheral nervous system diseases / Dorothée Chabas, Isabelle Cournu-Rebeix, and Bertrand Fontaine -- Immunogenetics of rheumatoid arthritis, systemic sclerosis, and systemic lupus erythematosus / Allison Porter and J. Lee Nelson -- Gastroenterologic and hepatic diseases / Marcela K. Tello-Ruiz, Emily C. Walsh, and John D. Rioux -- Inflammatory myopathies : dermatomyositis, polymyositis, and inclusion body myositis / Renato Mantegazza and Pia Bernasconi -- Hematologic diseases : autoimmune hemolytic anemia and immune thrombocytopenic purpura / Mattias Olsson ... [et al.] -- Genetics of autoimmune myocarditis / Mehmet L. Guler, Davinna Ligons, and Noel R. Rose.
  • 2008 Springer
    Møller, Eva Horn; Weert, Marco van de.
  • 2010 Springer
    Buchwalow, Igor B.; Böcker, W.
  • 2008 Springer
    Brusic, Vladimir; Ranganathan, Shoba; Schönbach, Christian.
    IMGT-ONTOLOGY, IMGT databases, tools, and web resources for immunoinformatics / Marie-Paule Lefranc -- IMGT standardization for molecular characterization of the T cell receptor/peptide/MHC complexes / Quentin Kaas ... [et al.] -- Structural immunoinformatics / Choba Ranganathan, Joo Chuan Tong, and Tin Wee Tan -- In silico QSAR-based predictions of class I and class II MHC epitopes / Channa K. Hattotuwagama ... [et al.] -- Allergen bioinformatics / Bernett T.K. Lee and Vladimir Brusic -- Immunoinformatics applied to modifying and improving biological therapeutics / Anne S. De Groot ... [et al.] -- Plasticity of dentritic cell transcriptional responses to antigen: functional states of dendritic cells / Paul Kellam and Antonia Kwan -- Understanding the immune system sytem by computer-aided modeling / Massimo Bernaschi and Filippo Castiglione -- Simulation of HIV-1 molecular evolution in response to chemokine coreceptors and antibodies / Jack da Silva -- MUTANT MOUSE: bona fide biosimulator for the functional annotation of gene and genome networks / Yoichi Gondo.
  • 2007 Springer Protocols
    Flower, Darren R.
  • 2011 Springer
    Marincola, Francesco M.; Wang, Ena.
    pt. 1. Preamble -- pt. 2. The immune biology of rejection : basic principles -- pt. 3. Circulating patterns associated with chronic and acute immune pathology -- pt. 4. Tissue-specific patterns associated with chronic inflammatory processes -- pt. 5. Signatures associated with acute rejection.
  • 2013 Springer
    Fairchild, Paul J.
    Recent years have witnessed numerous advances in stem cell research that have suggested novel strategies for the treatment of the chronic and regenerative diseases that pose a growing challenge to the provision of healthcare in the 21<sup>st</sup> century. Nevertheless, there is little doubt that related disciplines have failed to keep pace with such developments, of which the immunology of transplant rejection is perhaps the most relevant to the nascent field of regenerative medicine. Indeed, given that after decades of research into the mechanisms of organ allograft rejection, we remain wholly dependent on immune suppression to ensure acceptance of foreign tissues, we might legitimately ask whether there is any reason why tissues differentiated from stem cells might not suffer the same fate. This volume seeks to address this issue by drawing on the principles of alloantigen recognition to assess the validity of early convictions that embryonic stem cell-derived tissues may prove invisible to the immune system of the host and the more recent belief that induced pluripotent stem cells, derived in a fully autologous manner, will circumvent the issue of immunogenicity. Having debunked such assumptions and established the magnitude of the immunological barriers to be overcome, this book then draws on the expertise of internationally-recognised laboratories around the world to provide a critical assessment of the likely success of applying strategies such as stem cell banking, silencing of genes that confer immunogenicity, and the induction of transplantation tolerance to overcoming the immunological barriers in the future. Indeed, it is only through reaching a consensus in the field that enduring solutions to such an intractable problem may ultimately emerge.
  • 2014 Springer
    Chen, Jun.
    Recent research has revealed the importance of immunological mechanisms and inflammation in delaying damage and/or promoting repair after an acute injury to the central nervous system. This book provides a comprehensive and up-to-date overview of the role of immunological mechanisms and therapies for treating acute neurological injuries such as cerebral ischemia, hemorrhage, and brain and spinal cord trauma. In several sections, the contributing authors provide a review of immunological mechanisms involved in neurological injury and of various translational and clinical research aimed at harnessing those mechanisms for better patient outcomes.
  • 2010 Springer
    Batista, Facundo; Saito, Takashi.
    Insights into function of the immunological synapse from studies with supported planar bilayers / M.L. Dustin -- Immunological synapses within context: patterns of cell-cell communication and their application in T-T interactions / J. Doh and M.F. Krummel -- Molecular and cellular dynamics at the early stages of antigen encounter: the B-cell immunological synapse / Y.R. Carrasco -- Inhibitory and regulatory immune synapses / P. Eissmann and D.M. Davis -- The immunological synapse, TCR microclusters, and T cell activation / T. Yokosuka and T. Saito -- Signaling amplification at the immunological synapse / A. Viola, R.L. Contento and B. Molon -- Multiple microclusters: diverse compartments within the immune synapse / S.C. Bunnell -- A conformation-induced oligomerization model for B cell receptor microclustering and signaling / P. Tolar and S.K. Pierce -- Co-receptors and recognition of self at the immunological synapse / N.R. Gascoigne ... [et al.] -- Vesicle traffic to the immunological synapse: a multifunctional process targeted by lymphotropic viruses / A. Alcover and M.I. Thoulouze -- Plasticity of immunological synapses / S. Valitutti and L. Dupre -- APC, T cells, and the immune synapse / P. Reichardt, B. Dornbach and M. Gunzer.
    Also available: Print – yyyy
  • 2007 Springer Protocols
    Fairchild, Paul J.
  • 2002 NCBI Bookshelf
    Frank, Steven A.
  • 2005 Springer
    Langhorne, J.
    The dissection of CD8 T cells during liver-stage infection / U. Krzych and R.J. Schwenk -- Early interactions between blood-stage Plasmodium parasites and the immune system / B.C. Urban, R. Ing, and M.M. Stevenson -- Longevity of the immune response and memory to blood-stage malaria infection / A.H. Achtman ... [et al.] -- Experimental models of cerebral malaria / C. Engwerda ... [et al.] -- Glycosylphosphatidylinositols in malaria pathogenesis and immunity : potential for therapeutic inhibition and vaccination / C.S. Boutlis ... [et al.] -- The immunology and pathogenesis of malaria during pregnancy / J.G. Beeson and P.E. Duffy.
    Also available: Print – 2005
  • 2015 Springer
    Müller, N.; Myint, Aye-Mu; Schwarz, Markus J.
    Psychiatric disorders are one of the most dramatic burdens for humankind. The role of immune dysfunction in the pathophysiology of these disorders has emerged during the last years, because there has been tremendous progress in psychoneuroimmunological research. Many results are presented here by pioneers in the field. The book addresses various effects of the immune system on the pathophysiology and course of psychiatric disorders and highlights the possible future impact on treatment decisions of various psychiatric disorders, including schizophrenia and depression. The contributions cover the role of in utero immune challenges on the development of schizophrenia, the role of infections, and autoimmune diseases and mild immune activation in the development of depression and schizophrenia, the influence of immune responses in other disorders such as Tourette's, Alzheimer's, and OCD, the connections between mental and physical pain as well as between anti-inflammatory and antipsychotic drugs.
  • 2009
    Turgeon, Mary Louise.
    PrintStatus: Not Checked OutLane Catalog Record
  • 2009
    Playfair, J. H. L.; Chain, B. M.
    PrintStatus: Not Checked OutLane Catalog Record
  • 2012 ScienceDirect
    Flaherty, Dennis K.
    With a new pharmacy-specific approach to immunology, Immunology for Pharmacy prepares pharmacists for practice by providing a complete understanding of the basis of immunology and the consequences of either suppressing or enhancing immune function. It covers key subjects such as prophylaxis and vaccination, antibodies as therapeutic and diagnostic agents, biological modifiers, and the rationale for use and mechanisms of therapeutic agents. Written by experienced author and educator Dennis Flaherty, this book presents topics with a logical, step-by-step approach, explaining concepts and their practical application. A companion Evolve website reinforces your understanding with flashcards and animations. Pharmacy-specific coverage narrows the broad field of immunology to those areas most pertinent and clinically relevant to pharmacy students. 165 full-color illustrations help to illuminate difficult concepts. Factors That Influence the Immune Response chapter covers biological agents including bacteria, viruses, and fungi, and their related toxins and how they relate to the immune system. Three chapters on vaccinations prepare you for this important part of the pharmacist's role by discussing cancer treatment with whole tumor vaccines, cell vaccines, and viral vector vaccines, describing other vaccines such as recombinant vaccines and plant vaccines, and examining how diseases such as diphtheria, whooping cough, and tetanus respond to vaccinations. A summary of drugs used in treating each condition helps you understand typical treatments and their immunological mechanisms, so you can choose proper treatments. Integrated information makes it easier to understand how various parts of the immune system work together, leading to a better understanding of immunology as a whole. A unique focus on practical application and critical thinking shows the interrelationship of concepts and makes it easier to apply theory to practice. Information on AIDS covers the identification and treatment of both strains of HIV as well as AIDS, preparing you for diseases you will see in practice. Unique student-friendly features simplify your study with learning objectives and key terms at the beginning of each chapter, bulleted summaries and self-assessment questions at the end of each chapter, and a glossary at the back of the book. Over 60 tables summarize and provide quick reference to important material. A companion Evolve website includes animations and pharmacy terminology flashcards.
  • 2014 Springer
    Massoud, Ahmad; Rezaei, Nima.
    An Introduction on the old age and aging of the immune system -- The immune system, a marker and modulator of the rate of aging -- Age-associated alterations of pleiotropic stem cell and the therapeutic implication of stem cell therapy in aging -- A role for epigenetic modulation of the innate immune response during aging -- Basophil, eosinophil and neutrophil functions in the elderly -- Dendritic cells and dysregulated immunity in the elderly -- Natural killer cell immunosenescence and cancer in the elderly -- Pattern recognition receptors and aging -- Impact of ageing on T cell repertoire and immunity -- T cell mediated immunity in the immunosenescence process -- Biological and phenotypic alterations of T cells in aging -- T cells seen from the metabolic and aging perspective -- Age-related alterations in regulatory T cells -- Effects of aging on B cells -- The role of MicroRNAs in immunosenescence process -- Immunogenetics of Aging -- Aging immunity and infection -- Influenza infection in the elderly -- Optimising response to vaccination in the elderly -- Nutrition, immunity and aging -- Diet and immunosenescence -- Dietary Intake and impact of zinc supplementation on the immune functions in elderly: nutrigenomic approach -- Physiological and pathological role of reactive oxygen species in the immune cells -- Oxidative stress in aging -- Skin aging and the immune system -- Aging immunity and the impact of physical exercise.
  • 2007 Springer
    Brown, Gordon D.; Netea, Mihai G.
  • 2005 Karger
    Markert, Udo R.
    Also available: Print – 2005
  • 2006
    Manyonda, Isaac T.
    PrintStatus: Not Checked OutLane Catalog Record
  • 2010 ScienceDirect
    Kabelitz, Dieter; Kaufmann, S. H. E.
    1. The Immune Response to Infectious Agents / Stefan H.E. Kaufmann, Dieter Kabelitz -- 2. Immunomagnetic Isolation of Subcellular Compartments / Vladimir Tchikov, Jürgen Fritsch, Dieter Kabelitz, Stefan Schütze -- 3. Use of Bioinformatics to Predict MHC Ligands and T-Cell Epitopes: Application to Epitope-Driven Vaccine Design / Anne S. De Groot, Tobias Cohen, Matthew Ardito, Lenny Moise, Bill Martin, Jay A. Berzofsky -- 4. Genetics of Susceptibility and Resistance to Infection / Aurelie Cobat, Marianna Orlova, Alexandre Alcaїs, Erwin Schurr -- 5. Proteomic Approaches to Study Immunity in Infection / Gustavo A.de Souza, Harald G. Wiker -- 6. Isolation and Characterization of Human Epithelial Antimicrobial Peptides and Proteins / Jens.-M. Schröder -- 7. Visualization and Functional Evaluation of Phagocyte Extracellular Traps / Maren von Köckritz-Blickwede, Ohn Chow, Mariam Ghochani, Victor Nizet -- 8. Killer Cell Assays / Patricia Graef, Veit R. Buchholz, Dirk H. Busch -- 9. Analysis of Intestinal T Cell Populations and Cytokine Productions / Jun Kunisawa, Hiroshi Kiyono -- 10. Isolation and Measuring the Function of Professional Phagocytes: Murine Macrophages / Leanne Peiser, Subhankar Mukhopadhyay, Richard Haworth, Siamon Gordon -- 11. Measuring Immune Responses In Vivo / Stefan Ehlers, Norbert Reiling, Christoph Hölscher, Sahar Aly -- 12. Murine and Guinea Pig Models of Tuberculosis / Diane J. Ordway, lan M. Orme -- 13. The Leishmaniasis Model / Pascale Kropf, Ulrich D. Kadolsky, Matthew Rogers, Thomas E. Cloke, Ingrid Müller -- 14. Animal Models of Mucosal Candida Infections / Flavia De Bernardis, Silvia Arancia, Silvia Sandini -- 15. Mucosal Immunity and Inflammation / Ulrich Steinhoff, Alexander Visekruna -- 16. CD8 T-Cell Immunotherapy of Cytomegalovirus Disease in the Murine Model / Niels A.W. Lemmermann, Jürgen Podlech, Christof K. Seckert, Kai A. Kropp, Natascha K.A. Grzimek, Matthias J. Reddehase, Rafaela Holtappels -- 17. Measuring Immune Responses In Situ: Immunofluorescent and Immunoenzymatic Techniques / Antje Müller, Torsten Goldmann, Ulrike Seitzer -- 18. Measuring Human Cytokine Responses / Hans Yssel, John Wijdenes, René de Waal Malefyt, Jean-François Mathieu, Jérôme Pène -- 19. Human Dendritic Cell Subsets / Hideki Ueno, Eynav Klechevsky, A. Karolina Palucka, Jacques Banchereau.
  • 2006 Springer
    Mor, Gil.
    Evolution of the mammalian reproductive tract and placentation / Susan Richman and Frederick Naftolin -- Toll-like receptors and pregnancy / Vikki M. Abrahams and Gil Mor -- IL-10 and pregnancy / Shaun P. Murphy and Surendra Sharma -- Th1/Th2 balance of the implantation site in humans / Shigeru Saito, Satomi Miyazaki, and Yasushi Sasaki -- The regulation of human trophoblast apoptosis and survival during pregnancy / Shawn L. Straszewski-Chavez and Gil Mor -- Macrophages and pregnancy / Gil Mor, Roberto Romero, and Vikki M. Abrahams -- Potential role of glucocorticoids in the pathophysiology of intrauterine growth restriction (IUGR) / Seth Guller, Yuehong Ma, and Men-Jean Lee -- NK cells and pregnancy / Mikael Eriksson, Satarupa Basu, and Charles L. Sentman -- The role of corticotropin-releasing hormone (CRH) on implantation and immunotolerance of the fetus / Sophia N. Kalantaridou ... [et al.] -- Indoleamine 2,3 dioxygenase-dependent T cell suppression and pregnancy / Babak Baban, Phillip R. Chandler, and Andrew L. Mellor -- Leukemia inhibitory factor in reproduction / Levent M. Senturk and Aydin Arici -- Characterization of human dendritic cells at the materno-fetal interface / Ulrike Kämmerer ... [et al.] -- MHC molecules of the preimplantation embryo and trophoblast / Martina Comiskey, Carol M. Warner, and Danny J. Schust -- Actions of seminal plasma cytokines in priming female reproductive tract receptivity for embryo implantation / Sarah A. Robertson ... [et al.] -- B7 family molecules in the placenta / Margaret G. Petroff -- The role of regulatory T cells in materno-fetal tolerance / Varuna R. Aluvihare and Alexander G. Betz -- The eutherian fetoembryonic defense system hypothesis: an update / Gary F. Clark ... [et al.] -- The nature and role of the decidual T cells / Lucia Mincheva-Nilsson and Vladimir Baranov -- Trophoblast cells as immune regulators / Gil Mor and Vikki M. Abrahams -- Inherited thrombophilias and early pregnancy loss / Jens Langhoff-Roos ... [et al.] -- Bi-directional cell trafficking during pregnancy: long-term consequences for human health / Kristina M. Adams and J. Lee Nelson -- Term and preterm parturition / Roberto Romero ... [et al.] -- Interleukin-1 and implantation / Jan-S. Krüssel ... [et al.] -- Immunology and pregnancy losses: HLA, autoantibodies and cellular immunity / Joanne Kwak-Kim, Joon Woo Kim, and Alice Gilman-Sachs.
  • 2005 Karger
    Markert, Udo R.
    Also available: Print – 2005
  • 2014 Springer
    Weissenbacher, E. R.
    Fundamentals of immunology: Concepts of innate and specific immunity -- Mucosal immunology -- General immunology of the genital tract: Distinct features of the genital mucosal tissue -- Functions and regulation of innate immune responses in the human reproductive tract -- Functions and regulation of adaptive humoral and cell-mediated immunity in the female genital tract -- Immunization studies -- Immunology of menstruation {u2013} menstruation as an inflammatory process -- Immunology of genital tract infections: Viral infections of the genital tract -- Bacterial infections of the genital tract -- Candidiasis -- Trichomoniasis -- Immunology in reproductive medicine: Immunology of pregnancy -- Immunologic infertility -- Immunocontraceptive approaches.
  • 2013 Springer
    Santambrogio, Laura.
    Immunology of the Lymphatic System is a comprehensive study of the lymphatic system and its immunological role. It begins with lymphatic capillaries, their origin and development. It addresses lymph circulation, in general, with a special emphasis on lymph circulation in parenchymal organs. The next section focuses on lymph nodes, subcortical circulation and the conduit system. It discusses organs with no lymphatic system, such as the brain. Finally, it covers lymph composition and cells in the lymph. While primarily basic research, the volume touches upon elements of the clinical, as well, broadening its scope and appeal.
  • 2008 Springer
    Beutler, Bruce.
    The forward genetic dissection of afferent innate immunity / B. Beutler and E.M. Moresco -- Genetic analysis of resistance to infections in mice: A/J meets C57BL/6J / J.F. Marquis and P. Gros -- Host defenses against human papillomaviruses: lessons from epidermodysplasia verruciformis / G. Orth -- Innate resistance to flavivirus infections and the functions of 2'-5' oligoadenylate synthetases / T. Mashimo, D. Simon-Chazottes and J.L. Guenet -- Cmv1 and natural killer cell responses to murine cytomegalovirus infection / A.A. Scalzo and W.M. Yokoyama -- Genetic dissection of host resistance to Mycobacterium tuberculosis: the sst1 locus and the Ipr1 gene / I. Kramnik -- Scurfy, the Foxp3 locus, and the molecular basis of peripheral tolerance / M.W. Appleby and F. Ramsdell -- Fevers, genes, and innate immunity / J.G. Ryan and D.L. Kastner -- Itchy mice: the identification of a new pathway for the development of autoimmunity / L.E. Matesic, N.G. Copeland and N.A. Jenkins -- TIM gene family and their role in atopic diseases / D.T. Umetsu ... [et al.].
    Also available: Print – 2008
  • 2013 ClinicalKey
    Male, David K.
    This textbook teaches the basic and clinical immunology concepts.
  • 2006
    Brostoff, Jonathan; Male, David K.; Roitt, Ivan Maurice; Roth, David B.
    PrintStatus: Not Checked OutLane Catalog Record
  • 2013 Springer
    Flower, Darren R.; Perrie, Yvonne.
    This book seeks to expand the horizons of vaccine design and discovery by highlighting cutting edge work in three areas of vaccinology: the rational discovery of subunit vaccines, the identification of adjuvants, and the delivery of vaccines via state-of-the-art nanotechnology.
  • v. 2-, 2009- Springer
  • 2014 CRCnetBASE
    Aggarwal, Bharat B.; Heber, David.
    Chapter 1. Evolution of innate and adaptive immunity / David Heber and Bharat B. Aggarwal -- chapter 2. Cellular mechanisms of cytokine activation / David Heber and Bharat B. Aggarwal -- chapter 3. Cellular lipids and inflammation / David Heber and Susanne Henning -- chapter 4. Biomarkers of inflammation and the Western diet / David Heber and Susanne Henning -- chapter 5. Phytochemicals and immune function / David Heber -- chapter 6. Genetic and environmental modifiers of immune function / David Heber -- chapter 7. Cancer and inflammation / David Heber -- chapter 8. Abdominal obesity : pathophysiology and related metabolic complications / Ana F.T.A. Junqueria and Caroline M. Apovian -- chapter 9. Type 2 diabetes and inflammation / Zhaoping Li and David Heber -- chapter 10. Heart disease and inflammation / Kaveh Daniel Navab -- chapter 11. Chronic kidney disease and inflammation / Karl J. Neff and Carel Le Roux -- chapter 12. Alzheimer's disease and inflammation / Stephen T. Chen and Gary W. Small -- chapter 13. Nutrition in autoimmunity : a focus on systemic lupus erythematosus and rheumatoid arthritis / Maureen McMahon -- chapter 14. Asthma and inflammation / Andre Nel and David Heber -- chapter 15. Muscle and immune function / Anthony Thomas and David Heber -- chapter 16. Approaches to reducing abdominal obesity / Zhaoping Li and David Heber -- chapter 17. Barriers to fruit and vegetable consumption and practical strategies for increasing fruit and vegetable intake / Susan Bowerman -- chapter 18. Healthy fats and oils : balancing omega-3 and omega-6 acids in tissues / Bill Lands -- chapter 19. Spices and dietary supplements with anti-inflammatory activity / Bharat B. Aggarwal and David Heber.
  • 2015 Karger
    Coukos, George; Michielin, Olivier.
    Immunotherapies in early and advanced renal cell cancer / Kasenda, B., Larkin, J., Gore, M. -- Immunotherapy of brain tumors / Dutoit, V., Migliorini, D., Walker, P.R., Dietrich, P.-Y. -- Immunotherapy of melanoma / Snyder, A., Zamarin, D., Wolchok, J.D. -- Immunotherapy of breast cancer / Criscitiello, C., Curigliano, G. -- Current developments in actively personalized cancer vaccination with a focus on RNA as the drug format / Diken, M., Kreiter, S., Kloke, B., Sahin, U. -- Immune checkpoint inhibitors / Haanen, J.B.A.G., Robert, C. -- Radiotherapy and immunotherapy : improving cancer treatment through synergy / Reynders, K., De Ruysscher, D. -- Combinations therapies / Reinmuth, N., Reck, M. -- Promise of immunotherapy in lung cancer / Shanker, A., Dikov, M.M., Carbone, D.P. -- T cell engineering / Pircher, M., Schirrmann, T., Petrausch, U.
  • 2008 Springer
    Khan, Manzoor M.
  • 2006 ScienceDirect
    O'Hagan, Derek T.; Schijns, Virgil E. J. C.
    Microparticles as vaccine delivery systems / Derek T. O'Hagan -- MF59: a safe and potent adjuvant for human use / Audino Podda, Giuseppe Del Giudice, and Derek T. O'Hagan -- Development and evaluation of AS04, a novel and improved adjuvant system containing MPL and aluminium salt / Nathalie Garçon, Marcelle van Mechelen, and Martine Wettendorff -- Virosomes for vaccine delivery / Ian C. Metcalfe and Reinhard Glück -- The ISCOMATRIX adjuvant / Debbie Drane and Martin J. Pearse -- Mineral adjuvants / Erik B. Lindblad -- Mucosal adjuvants based on cholera toxin and E. coli heat-labile enterotoxin / Jan Holmgren ... [et al.] -- Transcutaneous immunization using the heat-labile enterotoxin of E. coli as an adjuvant / Richard T. Kenney and Gregory M. Glenn -- T cell adjuvants and novel strategies for their identification / Laurence Van Overvelt and Philippe Moingeon -- Vaccination to treat noninfectious diseases: surveying the opportunities / Stephen W. Martin and Martin F. Bachmann -- Clinical evaluation of adjuvants / Jakub K. Simon and Robert Edelman -- Regulatory considerations in the nonclinical safety assessment of adjuvanted preventive vaccines / Elizabeth M. Sutkowski and Marion F. Gruber. Unravelling "the immunologist's dirty little secret" / Virgil E.J.C. Schijns -- Dendritic cells as targets and tools in vaccines / Imerio Capone, Paola Rizza, and Filippo Belardelli -- Host-derived molecules as adjuvants / Tom Barr, Jennifer Carlring, and Andrew W. Heath -- Innate immune mechanisms and the identification of immune potentiators as vaccine adjuvants / Achal Pashine, Jeffrey B. Ulmer, and Nicholas M. Valiante -- CpG oligodeoxynucleotides as vaccine adjuvants / Michael J. McCluskie and Risini D. Weeratna -- Toll-like receptor 4 agonists as vaccine adjuvants / David H. Persing ... [et al.] -- Immunomodulatory adjuvants from Quillaja saponaria / Charlotte Read Kensil --
    Also available: Print – 2006
  • 2013 Springer Protocols
    Fulton, Kelly M.; Twine, Susan M.
    Introduction to the immune system / Scott McComb ... [et al.] -- Immunoproteomics : current technology and applications / Kelly M. Fulton and Susan M. Twine -- Antigen identification using SEREX / Ugur Sahin and Özlem Türeci -- Antigen discovery using whole-genome phage display libraries / Elisa Beghetto and Nicola Gargano -- Methods and applications of serological proteome analysis / Kelly M. Fulton ... [et al.] -- Pre-absorbed immunoproteomics : a novel method for the detection of bacterial surface proteins / Guangjin Liu, Wei Zhang, and Chengping Lu -- Identification of the antigen content of electroimmunoprecipitates / N. Helena Beyer and Niels H.H. Heegaard -- Immunoproteomics approach to screen the antigenicity of the influenza virus / Kevin M. Downard -- In vivo microbial antigen discovery (InMAD) to identify diagnostic proteins and polysaccharides that are circulating during microbial infections / Sindy J. Chaves ... [et al.] -- Chemo-enzymatic production of O-glycopeptides for the detection of serum glycopeptide antibodies / Alexander Nøstdal and Hans H. Wandall -- Enrichment and characterization of glycopeptide epitopes from complex mixtures / Luc Tessier, Kelly M. Fulton, and Susan M. Twine -- Whole-cell MALDI-TOF mass spectrometry : a tool for immune cell analysis and characterization / Richard Ouedraogo ... [et al.] -- Cell-based arrays for the identification of interacting polypeptide domains or epitopes / Richard H. Maier, Christina J. Maier, and Kamil Önder -- Identification and quantitation of MHC class II-bound peptides from mouse spleen dendritic cells by immunoprecipitation and mass spectrometry analysis / Leonia Bozzacco and Haiqiang Yu -- Construction and screening of an antigen-derived peptide library displayed on yeast cell surface for CD4+ T cell epitope identification / Fei Wen and Huimin Zhao -- Profiling of cytokine and chemokine responses using multiplex bead array technology / Greg Harris and Wangxue Chen -- Preparation of the low molecular weight serum proteome for mass spectrometry analysis / Timothy J. Waybright ... [et al.] -- Identification of protein biomarkers in human serum using iTRAQ and shotgun mass spectrometry / Theodoros A. Koutroukides ... [et al.] -- Genome-based bioinformatic prediction of major histocompatibility complex (MHC) epitopes / Simon J. Foote -- Structure-based prediction of major histocompatibility complex (MHC) epitopes / Andrew J. Bordner -- Prioritization of therapeutic targets of inflammation using proteomics, bioinformatics, and in silico cell-cell interactomics / Arsalan S. Haqqani and Danica B. Stanimirovic -- Commercial considerations for immunoproteomics / Scott M. Ferguson.
  • 2015 Springer Protocols
    Shaw, Albert C.
    Isolation of lipid rafts from human neutrophils by density gradient centrifugation / Carl Fortin and Tamas Fülöp -- Flow cytometry analysis of NK cell phenotype and function in aging / Raquel Tarazona ... [et al.] -- Flow cytometric identification of fibrocytes in the human circulation / Xinyuan Hu, Erin M. DeBiasi, and Erica L. Herzog -- Experimental approaches to tissue injury and repair in advanced age / Aleah L. Brubaker, Stewart R. Carter, and Elizabeth J. Kovacs -- Multicolor digital flow cytometry in human translational immunology / Samit R. Joshi, Subhasis Mohanty, and Albert C. Shaw -- Flow cytometry-based methods to characterize immune senescence in nonhuman primates / Christine Meyer ... [et al.] -- Multiparameter phenotyping of human PBMCs using mass cytometry / Michael D. Leipold, Evan W. Newell, and Holden T. Maecker -- Imaging immunosenescence / Feng Qian and Ruth R. Montgomery -- Activation-induced cytidine deaminase and switched memory B cells as predictors of effective in vivo responses to the influenza vaccine / Daniela Frasca, Alain Diaz, and Bonnie B. Blomberg -- Analyzing the effect of aging on CD8+ T-cell phenotype using flow cytometry / Min Sun Shin and Insoo Kang -- Cell-mediated immune response to influenza using ex vivo stimulation and assays of cytokine and granzyme B responses / Janet E. McElhaney and Beth Gentleman -- Assays for monitoring macroautophagy activity in T cells / Yair Botbol and Fernando Macian -- Fluorescence-based approaches for quantitative assessment of protein carbonylation, protein disulfides, and protein conformation in biological tissues / Asish R. Chaudhuri ... [et al.] -- Monitoring the DNA damage response at dysfunctional telomeres / Rekha Rai and Sandy Chang -- Single-cell analysis of T-cell receptor Αβ repertoire / Pradyot Dash, George C. Wang, and Paul G. Thomas -- Assessment of B cell repertoire in humans / Yu-Chang Wu, David Kipling, and Deborah Dunn-Walters -- Laboratory and data analysis methods for characterization of human B cell repertoires by high-throughput DNA sequencing / Chen Wang ... [et al.] -- Discovery of novel microRNAs in aging Caenorhabditis elegans / Alexandre de Lencastre and Frank Slack -- Analysis of DNA methylation by pyrosequencing / Colin Delaney, Sanjay K. Garg, and Raymond Yung.
  • 2012 Springer
    Thiel, Andreas.
  • 2013 Springer
    Bosch, Jos A.; Lord, Janet M.; Phillips, Anna C.
    This book presents the first multi-disciplinary approach to the understanding of immune aging, or immunosenescence; it combines biological data and clinical observations with psychological, social, and behavioral perspectives and is thus a valuable and timely contribution to the literature in this area. Contributors, all eminent scholars in their respective fields, review thoroughly the state of the art in research that examines how psychological and behavioral factors influence the rate and extent of immune system aging.
  • 2012 Future Med
    Cervera, Ricard; Meroni, Pier-Luigi; Shoenfeld, Yehuda.
    Immunotherapeutic agents for SLE / Yehuda Shoenfeld, Pier Luigi Meroni & Ricard Cervera -- Immunopathogenesis of SLE and drug targets / Arvind Kaul, David D'Cruz & Graham R.V. Hughes -- Rituximab in SLE / Cándido Díaz-Lagares, Manuel Ramos-Casals & Munther A. Khamashta -- Belimumab in SLE / Ricard Cervera & Gerard Espinosa -- Epratuzumab in SLE / David M. Goldenberg & Daniel J. Wallace -- Intravenous immunoglobulin therapy for SLE / Ziv Rozman & Gisele Zandman-Goddard -- Other novel immunotherapeutic agents in the pipeline and future directions / Ana M. Bertoli & Graciela S. Alarcón -- Index.
  • 2007 Springer
    Radbruch, A.
  • 2015 ScienceDirect
    Fisher, Paul B.; Wang, Xiang-Yang.
  • 2006 Springer
    Disis, Mary L.
    Discovery of target molecules for cancer immunotherapy by genetic and bioinformatic approaches -- Current strategies for the identification of immunogenic epitopes of tumor antigens -- Current and future role of natural-killer cells in cancer immunotherapy -- The role of immune monitoring in evaluating cancer immunotherapy -- Statistical analysis of immune response assays -- DNA vaccines for cancer immunotherapy -- Dendritic cells -- Different approaches to dendritic cell-based cancer immunotherapy -- Anti-idiotype antibody vaccines for the immunotherapy of cancer -- Autologous tumor-derived heat shock protein vaccine as a new paradigm for individualized cancer therapeutics -- Tumor-reactive T-cells for adoptive immunotherapy -- T-cell adoptive immunotherapy of cancer: from translational models to clinical significance -- Retroviral-mediated gene transfer for engineering tumor-reactive T-cells -- Harnessing the potential of graft-vs-tumor -- Tumor-induced immune suppression and immune escape: mechanisms and impact on the outcome of immunotherapy of malignant disease -- The tumor microenvironment: regulation of antitumor immunity and implications for immunotherapy -- Manipulation of lymphocyte homeostasis for enhancing antitumor immunity -- Fast-lane evolution in the tumor microenvironment -- Manipulating immunological checkpoints to maximize antitumor immunity -- Interleukin-2 as cancer therapy -- Biological and clinical properties of the type 1 interferons -- Promising g [gamma]-chain cytokines for cancer immunotherapy: interleukins-7, -15, and -21 as vaccine adjuvants, growth factors -- The therapeutic use of natural-killer cells in hematological malignancies -- Antibody therapy for solid tumors -- Antibody therapy for non-Hodgkin's lymphoma -- Approaches to in vivo imaging of cancer immunotherapy -- Design issues for early-stage clinical trials for cancer vaccines -- Monoclonal antibody therapy for cancer.
  • 2010 Springer Protocols
    Yotnda, Patricia.
    Hypoxic tumors and their effect on immune cells and cancer therapy / Patricia Yotnda, Danli Wu, and Anna May Swanson -- Characterization of regulatory T cells in tumor suppressive microenvironments / Guangyong Peng -- Generation of cytotoxic T lymphocytes for immunotherapy of EBV-associated malignancies / Corey Smith and Rajiv Khanna -- Acquisition, preparation, and functional assessment of human NK cells for adoptive immunotherapy / Dean A. Lee, Michael R. Verneris, and Dario Campana -- Enhanced migration of human dendritic cells expressing inducible CD40 / Natalia Lapteva -- Differentiation of human embryonic stem cells into hematopoietic cells in vitro / Eun-Mi Kim and Nicholas Zavazava -- Gene therapy to improve migration of T cells to the tumor site / Antonio Di Stasi, Biagio De Angelis, and Barbara Savoldo -- Gene therapy to improve function of T cells for adoptive immunotherapy / Concetta Quintarelli, Barbara Savoldo, and Gianpietro Dotti -- Cytokine-FC fusion genes as molecular adjuvants for DNA vaccines / Daniel Hirschhorn-Cymerman and Miguel-Angel Perales -- Pharmacology of anti-CD3 diphtheria immunotoxin in CD3 positive T-cell lymphoma trials / Jung Hee Woo ... [et al.] -- Construction of human antibody gene libraries and selection of antibodies by phage display / Thomas Schirrmann and Michael Hust -- Identification of immunogenic peptides of the self-tumor antigen : our experience with telomerase reverse transcriptase / Xochitl Cortez-Gonzalez and Maurizio Zanetti -- Rescue, amplification, purification, and PEGylation of replication defective first-generation adenoviral vectors / Michael A. Barry, Eric A. Weaver, and Sean E. Hofherr -- Adenovirus-mediated interleukin (IL)-24 immunotherapy for cancer / Rajagopal Ramesh ... [et al.] -- Liposomes for gene transfer in cancer therapy / Nancy Smyth Templeton -- Oncolytic HSV as a vector in cancer immunotherapy / Hongtao Li and Xiaoliu Zhang -- Generation of chimeric T-cell receptor transgenes and their efficient transfer in primary mouse T lymphocytes / Linda J. Howland, Nicole M. Haynes, and Phillip K. Darcy -- Multi-walled carbon nanotube (MWCNT) synthesis, preparation, labeling, and functionalization / Babak Kateb ... [et al.] -- Cellular immunotherapy of cancer / Fatma V. Okur and Malcolm K. Brenner.
  • 2012 Springer
    Dietert, Rodney R.; Luebke, Robert W.
    Immunotoxicity, Immune Dysfunction, and Chronic Disease is among the first books to illustrate the linkage between environmental risk factors (e.g., chemicals, drugs, diet, lifestyles), environmentally-induced immune dysfunction and the full range of resulting chronic diseases and conditions. There is a detailed discussion of specific immune-based chronic diseases and conditions that emerge in children and adults and affect different physiological systems. The book integrates a consideration of risk factors and specific immunotoxic alterations with disease outcomes. A significant number of diseases and conditions are discussed, such as systemic allergic diseases affecting the lung, skin and gastrointestinal tract, systemic autoimmune diseases (type 1 diabetes, multiple sclerosis and lupus) and chronic conditions that are not traditionally associated with chemically-mediated immunomodulation (depression, frailty, and atherosclerosis). Inflammatory dysregulation is a common thread that connects many of the diseases and conditions discussed in this book and provides a central focus. Individual chapters are organized by disease with the addition of chapters that provide integrative information on: 1) patterns of disease comorbidities and 2) the safety testing of chemicals and drugs to reduce the risk of immune dysfunction. Each chapter contains a summary of key points as well as recommendations when appropriate. The book stresses the benefits of identifying the environmental risk factors of immune-mediated chronic disease and the potential to reduce the prevalence of these diseases and conditions. This volume is a valuable resource for researchers, clinicians, risk assessors and regulators and students.
  • 2007 CRCnetBASE
    House, Robert V.; Kimber, Ian; Luebke, Robert W.
  • v.1, 2004 ScienceDirect
    Descotes, Jacques.
    v. 1. Principles and methods of immunotoxicology.
  • 2014 Springer
    Berger, Nathan A.; Bowen, Deborah; Denis, Gerald V.
    Obesity and Cancer in Appalachia -- Disparities in Cancer Outcomes A UK Perspective -- Behavioral Differences Leading to Disparities in Energy Balance and Cancer -- Impact of obesity, race, and ethnicity on cancer survivorship -- The biology of aging: Role in cancer, metabolic dysfunction and health disparities -- Energy Balance and Multiple Myeloma in African Americans -- Single Nucleotide Polymorphisms in Obesity and Inflammatory Genes in African Americans with Colorectal Cancer -- Ethnic Differences in Insulin Resistance as a mediator of Cancer Disparities -- Role of ethnic differences in mediators of energy balance -- Community-Based Strategies to Alter Energy Balance in Underserved Breast Cancer Survivors -- The role of policy in reducing inflammation -- Cancer Prevention through Policy Interventions that Alter Childhood Disparities in Energy.
  • 2013 Springer
    El-Deiry, Wafik S.
    Novel antineoplastics targeting genetic changes in colorectal cancer / Jamal Joudeh...[et al.] -- Update on clinical trials: genetic targets in breast cancer / Bora Lim, Leah V. Cream, Harold A. Harvey -- Impace of genetic targets on cancer therapy in esophagogastric cancer / Yixing Jiang -- Impact of genetic targets on cancer therapy: hapatocellular cancer / Osama Hamed...[et al.] -- Toward the goal of personalizaed therapy in pancreatic cancer by targeting the molecular phenotype / Nelson S. Yee -- Impact of genetic markers on treatment of non-small cell lung cancer / Nicholas Lamparella, Amit Barochia, Salah Almokadem -- Impact of genetic targets on therapy in head and neck squamous cell carcinoma / Irina Chaikhoutdinov, David Goldenberg -- Tyrosine kinase targeted treatment of chronic myelogenous leukemia and other myeloproliferative neoplasms / Ajit Bisen, David F. Claxton -- Targeted tehrapy of multiple myeloma / Nathan G. Dolloff, Giampaolo Talamo -- Current and future trials of targeted therapies and cutaneous melanoma / Matthew S. Evans...[et al.] -- Current approaches to epigenetic therapy for the treatment of mantle cell lymphoma / Vikas Ghai...[et al.] -- Impact of genetic targets on primary brain tumor therapy: what's ready for prime time / O. Zalatimo...[et al.] -- Rational therapy for renal cell carcinoma based on its genetic targets / Jaime Messer, Joseph Drabick, Matthew Kang -- Molecular and genetic markers of follicular-cell thyroid cancer : etiology and diagnostic and therapeutic opportunities / Neerav Goyal...[et al.] -- Genetic targets in pediatric acute lymphoblastic leukemia / Chandrika Gowda, Sinisa Dovat -- Emerging molecular therapies for the treatment of acute lymphoblastic leukemia / Monali Vasekar...[et al.] -- Impact of genetic targets on prostate cancer therapy / Hassan Sheikh...[et al.] -- Small-cell lung cancer : an update on targeted therapues / Monika Joshi, Ayodele Ayoola, Chandra P. Belani -- Impact of genetic targets on cancer therapy in acute myelogenous leukemia / Mithun Vinod Shah, Amit Barochia, Thomas P. Loughran.
    Also available: Print – 2013
  • 2013 ebrary
    2013 CRCnetBASE
    Srinivasan, Divya.
    HIPAA : stakeholder impacts and effects of provisions of the HITECH Act -- Organizational culture : what is needed to adopt HIT across different types of hospitals? -- Health economics : organizational finance and healthcare IT -- Cost benefit analysis and funding EMRs -- Analyzing the presence of EMRs across different health providers -- EMR impacts on quality of care and cost to the patient -- The physician and perceptions : medical malpractice and impacts from HIT usage -- Reduction in bioterrorism through the usage of EMRs -- The direction of health informatics and the future : the E-health industry.
  • 2008 Springer
    Faye, Bernard; Sinyavskiy, Yuriy.
  • 2014 Springer
    Berger, Nathan A.; Redline, Susan.
    This volume on the Impact of Sleep and Sleep Disturbances on Obesity and Cancer continues the transdisciplinary approach of this series with chapters authored by the leading experts in this field, focused on the normal regulation of the restorative sleep associated processes across the lifespan, the major mechanisms of sleep and circadian rhythm disturbances and the behavioral, physiologic, biochemical and molecular consequences of sleep disturbances. These areas, in turn, are discussed in relationship to their effects on cancer incidence and progression. Students and research scientists involved in all aspects of energy balance and cancer research and patient care should find this volume useful to better understand the causes, contributions and consequences of sleep and circadian rhythm disturbances and their relation to cancer. The volume outlines many exciting areas where research is needed. In addition to its value for researchers, it should be useful to all physicians and health care personnel who care for cancer patients and cancer survivors to better understand the importance of sleep, consequences of sleep disturbances and benefits of their correction.
  • 2009 Springer
    Anscher, Mitchell S.; Molls, M.; Nieder, C.; Vaupel, Peter.
  • 2012
    Prolo, Laura Marie; Barres, Ben A.; Garner, Craig C.; Reimer, Richard J.; Steinman, Lawrence.
    Lysosomal storage disorders are inherited diseases caused by defects in lysosomal function. The free sialic acid storage disorders are allelic diseases that are caused by mutations in the gene encoding a lysosomal membrane protein called sialin. This protein transports the acidic sugar, sialic acid, out of lysosomes after it has been cleaved off of glycoconjugates undergoing degradation. Accumulation of sialic acid in lysosomes defines these disorders, but it is not known how this biochemical defect leads to the clinical manifestations. Significant advances in our understanding of the pathophysiology and in treatment have been hindered by the lack of an animal model. In the studies described here I characterize a sialin deficient mouse and provide evidence that it faithfully models important aspects of the human disease. A major finding in the human disease and in the sialin-/- mouse is impaired central nervous system (CNS) myelination. To investigate potential mechanisms underlying CNS hypomyelination, I studied oligodendrocyte development and myelination in optic nerves of the sialin deficient mice. I found reduced numbers of myelinated axons, but the myelin that was present appeared grossly normal. Migration and density of oligodendrocyte precursor cells (OPCs) were normal; however, I observed a marked decrease in the number of postmitotic oligodendrocytes and an associated increase in the number of apoptotic cells during the later stages of myelinogenesis. These findings suggest that a defect in maturation of cells in the oligodendrocyte lineage leads to increased apoptosis and underlies the myelination defect associated with sialin loss. I hypothesized that improper metabolism of sialic acid containing proteins and lipids (gangliosides) may explain some aspects of the disease phenotype. I found a delay in the developmentally regulated reduction in expression of polysialic acid-neural cell adhesion molecule (PSA-NCAM), a glycoconjugate that inhibits myelin formation, which provides a potential molecular mechanism for the impaired myelination and reduction in oligodendrocyte number. Further, I found elevated levels of gangliosides in the sialin-/- mouse brain with the most noticeable change in the level of ganglioside GM2. To further studies of the myelination defect, I have established a cerebellar slice-OPC coculture myelination assay. This ex vivo system will allow investigators to test specific hypotheses about the cellular and molecular basis of the myelination defect and can eventually be used to assess potential treatments.
  • 2009 IngentaConnect
    Kichigina, Galina.
    Part I. The German laboratory and 'scientific medicine' in the late 1850s and early 1860s: a Russian view -- 1. The Old-new tradition -- 2. Physiologist-physicists: foundation of the discipline -- 3. A Viennese prelude: Sechenov's research at Ludwig's laboratory -- 4. Berlin wins over Paris and Vienna: Botkin's view on European clinics -- 5. 'Alt Heidelberg, du feine ...' -- Part II. The St Petersburg Medico-Surgical Academy and experimental science -- 6. Military medical education: the aftermath of the Crimean War -- 7. The Winds of change: reformation of the Medico-Surgical Academy -- 8. The 'Medico-Chemical Academy': Zinin's laboratory -- 9. Synthesis and symphonies: Borodin's laboratory -- 10. 'Scientific medicine': Botkin's teaching clinic and laboratory -- 11. The New discipline of Russian physiology: Sechenov's labortory 12. A Few steps further: the operation of the physiological laboratory under Cyon -- Part III. From physics and chemistry of the body to physical chemistry: Sechenov's research on blood gases and salt solutions -- 13. Russian universities in the sea of change, 1870-1886 -- 14. Sechenov at Novorossiisk University: new laboratory, new challenges -- 15. A Simple model: transition from blood-gas research to studies on salt solutions -- 16. Sechenov at St Petersburg: 'Galvanic studies'-- a final proof -- 17. The Context to Sechenov's study of solution: the Mendeleev-Ostwald debate on the theory of solutions -- The Universal law: expectations and disappointments.
    Also available: Print – 2009
  • 2010 ClinicalKey
    Garg, Arun K.
    Get the practical information you need to add dental implants to your practice! Dr. Arun Garg, a leading dental implant educator, clinician, and researcher, uses a clear, succinct writing style to inform and guide you through the full scope of dental implantology. A patient-focused approach covers surgical templates and techniques, sterilization, pharmacology, bone biology, complications, and more. A robust appendix offers handy information including insurance codes, consent forms, surgical tray set-ups, and food recipes for patients recovering from surgery. A practical yet comprehensive approach covers all aspects of implant dentistry from patient history to post-operative care, with minimal use of jargon, in an easy-to-read format. Outstanding photos help you visualize and understand patient outcomes. An appendix on post-operative instructions includes a unique section on delicious yet recovery-specific recipes.
  • 2015 Springer
    Albrektsson, Tomas; Jimbo, Ryo; Wennerberg, Ann.
    This book provides the reader with the knowledge required in order to understand the chemical, physical, mechanical, and topographical aspects of implant surfaces, as well as their impact on the biological response. Common ways to modify implant surfaces are described, and methods for the evaluation of surface properties are presented in an easy-to-read style. Experimental results that have contributed to surface modifications relevant for commercial available implants are presented, with emphasis on in vivo and clinical studies. While the focus is primarily on surface modifications at the micrometer and nanometer levels, alterations at the millimeter level are also covered, including thread designs and their possible influence on stress distribution. In addition, it is analyzed how surface alterations have changed the clinical long-term results for certain groups of patients. Care is taken to ensure that assessments are well balanced and draw attention to the potential disadvantages of different surfaces; for example, surfaces that may be more prone to biofilm accumulation are identified, with discussion of the clinical evidence.
  • 2011 Karger
    Caversaccio, Marco-Domenico; Kompis, Martin.
    Historical background of bone conduction hearing devices and bone conduction hearing aids / Mudry, A., Tjellström, A. -- Acoustic and physiologic aspects of bone conduction hearing / Stenfelt, S. -- An overview of different systems : the bone-anchored hearing aid / Dun, C.A.J. ... [et al.] -- The ponto bone-anchored hearing system / Westerkull, P. -- Partially implantable bone conduction hearing aids without a percutaneous abutment (otomag) : technique and preliminary clinical results -- Siegert, R. -- Surgery for the bone-anchored hearing aid / Arnold, A., Caversaccio, M.-D., Mudry, A. -- Paediatric baha / McDermott, A.-L., Sheehan, P. -- Complications of bone-anchored hearing devices / Wazen, J.J., Wycherly, B., Daugherty, J. -- Audiological results with Baha in conductive and mixed hearing loss / Pfiffner, F.; Caversaccio, M.-D.; Kompis, M. -- Conductive hearing loss and bone conduction devices : restored binaural hearing? / Agterberg, M.J.H. ... [et al.] -- Bone-anchored devices in single-sided deafness / Stewart, C.M.; Clark, J.H.; Niparko, J.K. -- Factors influencing the decision for baha in unilateral deafness : the Bern benefit in single-sided deafness questionnaire / Kompis, M. ... [et al.] -- Challenges and recent developments in sound processing for Baha / Flynn, M.C. -- Headbands, testbands and softbands in preoperative testing and application of bone-anchored devices in adults and children / Zarowski, A.J. ... [et al.] -- Bone-anchored hearing aids versus conventional hearing aids / Banga, R. ... [et al.] -- The future of bone conduction hearing devices / Håkansson, B.
  • 2013 Springer
    Korpas, David.
    History and development of pacing -- Basic principles of cardiac pacemaker technology -- Heart anatomy and physiology -- Pharmacological treatment of cardiac rhythm disorders -- Pacing modes -- Indications for implantable system treatment -- Leads -- Pacing systems -- Pacemaker timing -- Implantable cardioverter-defibrillators -- Cardiac resynchronization therapy -- Implantation, explantation, and replacement of devices and leads -- Patient follow-up -- Electromagnetic compatibility and technical requirements.
  • 2007 Springer
    Jordaens, L.; Theuns, Dominicus Anna Margaretha Johannes.
  • 2010
    O'Sullivan, Thomas Daniel; Gambhir, Sanjiv Sam; Harris, J. S.; Levi, Ofer.
    Molecular imaging is an established technique used to visualize and quantify functional information about biological processes in living systems. In vivo fluorescence imaging, in particular, is a molecular imaging technique capable of quantitatively imaging one or more fluorophores at high spatial and temporal resolution with high sensitivity, either at microscopic or macroscopic (whole-body) scales. While current fluorescent imaging technologies have led to key advances in the understanding of biology and biochemistry, there are limitations. Modern in vivo fluorescence imagers are bulky, and typically take snapshots, and only sample discrete points of continuous, dynamic processes. In order to overcome these obstacles and enable long-term, continuous fluorescence imaging in live animals, we have miniaturized the components of the optical imaging system, allowing for direct implantation. Miniature fluorescence sensors have been fabricated to match a particular fluorescent probe utilizing semiconductor processing technology and appropriate materials. We present the design and fabrication of a monolithically integrated semiconductor (GaAs-based) sensor for far-red to near infrared (NIR) in vivo fluorescence sensing. The sensor incorporates three basic components of a fluorescence system, including: a 675nm vertical-cavity surface-emitting laser (VCSEL) excitation source, a GaAs PIN photodiode, and a fluorescence emission filter. We have packaged the sensors in several integrated configurations, and developed readout mechanisms that include a system that can be implanted in small rodents. We have utilized this device to demonstrate that in vivo fluorescence imaging is possible with miniaturized, un-cooled semiconductor devices, including a demonstration of sensing in a freely-moving rodent. Such miniaturized, implantable biomedical devices have the potential to accelerate pre-clinical research and revolutionize clinical care by providing an inexpensive means for diagnosis, monitoring disease progression, and evaluating long-term treatment efficacy. By integrating this implantable sensor with the appropriate read-out electronics and wireless telemetry, un-tethered operation can ultimately be achieved.
  • 2014 Springer
    Mankekar, Gauri.
    Hearing loss can vary in type ranging from conductive, mixed to sensorineural, as well as in degree from mild, moderate, severe to profound. There could also be multiple permutations and combinations like moderate mixed hearing loss or severe conductive hearing loss. In addition, the hearing loss could be unilateral or bilateral. While cochlear implants were devised for bilateral profound sensorineural hearing loss, various other devices have been invented for other types of hearing losses. Research continues to design a suitable implant which would amplify sound for patients who cannot be candidates for cochlear implants.
  • 2013
    Peters, David H.; Adam, Taghreed; Tran, Nhan T.
    Also available: Print – 2013
  • 2014 WHO
    Also available: Print – 2014
  • 2005 Springer
    Bieber, Eric J.; Richards, Frank; Walker, James M.
    Organizational climate -- Needs assessment -- Vendor selection and contract negotiation -- Infrastructure -- Workflow assessment and redesign -- Staffing and managing implementation teams -- Usability -- Training -- Clinical decision support -- Translating scope of practice into effective EHR workflows -- System integration -- Production support -- Managing the client-vendor partnership -- Phased implementation -- Optimizing primary-care practices -- Special-purpose software -- Optimizing inpatient care -- Extending EHR access to patients -- Extending EHR access to external physicians -- Summary and prospects.
  • 2008 CRCnetBASE
    Adam, Azad.
  • 2010 CRCnetBASE
    Christian, Donnell R.; Drilling, Stephanie.
  • 2014 CRCnetBASE
    Leisch, Friedrich; Peng, Roger D.; Stodden, Victoria.
    Part 1. Tools -- part 2. Practices and guidelines -- part 3. Platforms.
  • 2008
    PrintStatus: Not Checked OutLane Catalog Record
  • 2005 NAP
    Hernandez, Lyla M.
  • 2005 NAP
    Coussens, Christine M.; Goldman, Lynn.
  • 2010 Karger
    Lucas, Alan; Makrides, Maria; Ziegler, Ekhard E.
    Growth and later health : a general perspective / Lucas, A -- Early infancy as a critical period for development of obesity and related conditions / Gillman, M.W -- Leptin, nutrition, and the programming of hypothalamic feeding circuits / Bouret, S.G -- Early growth and ageing / Chen, J.-H., Cottrell, E.C., Ozanne, S. -- Does early growth affect long-term risk factors for cardiovascular disease? / Singhal, A. -- Developing world perspective : the importance of growth for short-term health / Adair, L.S. -- Postnatal growth and development in the preterm and small for gestational age infant / Cooke, R.J. -- Interrelationship between growth and development in low and middle income countries / Martorell, R., Nguyen, P. -- Role of long-chain polyunsaturated fatty acids in neurodevelopment and growth / Makrides M., Gibson, R.A. -- Growth and development of the brain and impact on cognitive outcomes / Hüppi, P. -- Benefits and harms of iron supplementation in iron-deficient and iron-sufficient children / Domell'f, M. -- Effects of selective dropout on infant growth standards / Van Buuren, S. -- The 2000 centers for disease control and prevention growth charts : several insights after 8 years / Ogden, C.L. ... [et al.] -- Growth charts compared / Ziegler, E.E., Nelson, S.E. -- Body composition in infancy : impact on health later in life / Ellis, K.J. -- Endocrinology of growth / Rosenfeld, R.G.
  • 2013 Karger
    Makrides, Maria; Ochoa, Juan B.; Szajewska, Hania.
    Arginine and asthma / C.R. Morris -- Changes in arginine metabolism during sepsis and critical illness inÿchildren de betue, C.T.I. / N.E.P. Deutz -- Arginine deficiency caused by myeloid cells : importance, identification and treatment / J.B. Ochoa -- Glutamine supplementation in neonates : is there a future? / J. Neu -- Insulin in human milk and the use of hormones in infant formulas / R. Shamir, N. Shehadeh -- Diet, gut enterotypes and health : is there a link? / F.D. Bushman, J.D. Lewis, G.D. Wu -- Understanding immunomodulatory effects of probiotics / B. Pot, B. Folign, C. Daniel, C. Grangette -- Transforming growth factor and intestinal inflammation : the role of nutrition / F.M. Ruemmele, H. Garnier-Lenglin -- Microbiota modulation: can probiotics prevent/treat disease inÿpediatrics? -- / H. Szajewska -- Membrane composition and cellular responses to fatty acid intakes and factors explaining the variation in response / C. Agostoni, P. Ris, F. Marangoni -- Docosahexaenoic acid and its derivative neuroprotectin D1 displayÿneuroprotective properties in the retina, brain and centralÿnervous system / N.G. Bazan, J.M. Calandria, W.C. Gordon -- Branched-chain fatty acids in the neonatal gut and estimated dietary intake in infancy and adulthood / R.R. Ran-Ressler, R.P. Glahn, S. Bae, J.T. Brenna -- Clinical overview of effects of dietary long-chain polyunsaturated fatty acids during the perinatal period / S.A. Scholtz, J. Colombo, S.E. Carlson -- Dietary n-3 LC-PUFA during the perinatal period as a strategy to minimize childhood allergic disease / M. Makrides, A.W. Gunaratne, C.T. Collins.
  • 2002 WHO
    Chapter 1. Introduction -- Chapter 2. A Short History of Involvement in Drug Safety Monitoring by WHO -- Chapter 3. Partners in Pharmacovigilance -- Chapter 4. Pharmacovigilance in Drug Regulation -- Chapter 5. Pharmacovigilance in Clinical Practice -- Chapter 6. Pharmacovigilance in International Health -- Chapter 7. Conclusion and Considerations for the Future.
  • 2007 HighWire
    Gómez Sánchez, M.A; Torbicki, A.
  • 2002 ScienceDirect
    Aronson, Joshua Michael.
    Self and self-belief in psychology and education : a historical perspective / Frank Pajares and Dale H. Schunk -- Pygmalion effect and its mediating mechanisms / Robert Rosenthal -- Messages that motivate : how praise molds students' beliefs, motivation, and performance (in surprising ways) / Carol S. Dweck -- Paradox of achievement : the harder you push, the worse it gets / Edward L. Deci and Richard M. Ryan -- Improving the academic performance of college students with brief attributional interventions / Timothy D. Wilson, Michelle Damiani, and Nicole Shelton -- Self-handicapping and school : academic self-concept and self-protective behavior / Frederick Rhodewalt and Michael W. Tragakis -- Wisdom of practice : lessons learned from the study of highly effective tutors / Mark R. Lepper and Maria Woolverton -- Students' motivation during the middle school years / Allan Wigfield and Jacquelynne S. Eccles -- Self-efficacy and self-regulated learning : the dynamic duo in school performance / Pamela J. Gaskill and Anita Woolfolk Hoy -- Building empathy, compassion, and achievement in the jigsaw classroom / Elliot Aronson. Intelligence is not just inside the head : the theory of successful intelligence / Robert J. Sternberg -- Being and becoming a good person : the role of emotional intelligence in moral development and behavior / David A. Pizarro and Peter Salovey -- Mozart and the mind : factual and fictional effects of musical enrichment / Frances H. Rauscher -- Stereotype threat : contending and coping with unnerving expectations / Joshua Aronson -- Barrier of mistrust : how negative stereotypes affect cross-race mentoring / Geoffrey L. Cohen and Claude M. Steele -- Toward a resolution of an American tension : some applications of the helping model of affirmative action to schooling / Anthony R. Pratkanis, Marlene E. Turner, and Stanley B. Malos -- Social exclusion in the classroom : teachers and students as agents of change / Amanda W. Harrist and K. Denise Bradley.
  • 2005 NAP
    Ball, John; Nass, Sharyl J.
  • 2013
    The National Plan to Address Alzheimer's Disease requires the U.S. Department of Health and Human Services (HHS) Office of the Assistant Secretary for Planning and Evaluation (ASPE) and the Administration for Intellectual and Developmental Disabilities (AIDD) within the HHS Administration for Community Living (ACL) to establish a task force to create a plan of action to address the needs of specific populations disproportionally affected by Alzheimer's disease. These populations include people with younger-onset dementia, racial and ethnic minorities, and persons with Down syndrome and other intellectual disabilities. This report summarizes input and recommendations received from a wide variety of stakeholders for consideration by the members of the Federal Interagency Task Force.
  • 2008
    Lynn, Joanne; Schuster, Janice Lynch; Simon, Lin Noyes; Wilkinson, Anne M.
    PrintStatus: Not Checked OutLane Catalog Record
    Introduction: continuous quality improvement for better end-of-life care -- How to make improvement happen -- Preventing, assessing and treating pain -- Managing dyspnea and ventilator withdrawal -- Beyond the living will: advance care planning for all stages of health and disease -- Supporting people in difficult times: relationships, spirituality, and bereavement -- Continuity of care: improving transitions, continuity, and coordination of care in the health care system -- Caring for caregivers: helping staff to provide good care -- Hospital-based palliative care consults and units -- Law , policy, and finance -- Alzheimer's and other dementias: opportunities to honor life -- Opportunites to improve care for cancer patients -- Offering end-of-life services to patients with advanced heart or lung failure -- Depression and delirium -- Conclusion: getting started.
  • 2015 NAP, User has to register to download.
    Video NAP
    Ball, John; Balogh, Erin; Miller, Bryan T.
    Getting the right diagnosis is a key aspect of health care -- it provides an explanation of a patient's health problem and informs all subsequent health care decisions. The diagnostic process is a complex, collaborative activity that involves clinical reasoning and information gathering to determine a patient's health problem. According to Improving Diagnosis in Health Care, diagnostic errors -- inaccurate or delayed diagnoses -- persist throughout all settings of care and continue to harm an unacceptable number of patients. It is likely that most people will experience at least one diagnostic error in their lifetime, sometimes with devastating consequences. Diagnostic errors can lead to negative health outcomes, psychological distress, and financial costs. If a diagnostic error occurs, inappropriate or unnecessary treatment may be given to a patient or appropriate (and potentially lifesaving) treatment may be withheld or delayed.Improving Diagnosis in Health Care, a continuation of the landmark Institute of Medicine reports To Err is Human: Building a Safer Health System (2000) and Crossing the Quality Chasm: A New Health System for the 21st Century (2001) finds that diagnosis -- and, in particular, the occurrence of diagnostic errors -- has been largely unappreciated in efforts to improve the quality and safety of health care. Without a dedicated focus on improving diagnosis, diagnostic errors will likely worsen as the delivery of health care and the diagnostic process continue to increase in complexity. Just as the diagnostic process is a collaborative activity, improving diagnosis will require collaboration and a widespread commitment to change among health care professionals, health care organizations, patients and their families, researchers, and policy makers. The recommendations of Improving Diagnosis in Health Care contribute to the growing momentum for change in this crucial area of health care quality and safety
  • 2011 ebrary
    "Many Americans believe that the United States has one of the best health-care systems in the world and that consequently Americans enjoy better health than most of the world's populations. The data, however, do not support that belief. In fact, the United States is ranked 32nd in the world in life expectancy even though it is ranked third in total expenditures on health care as a percentage of gross domestic product (GDP). Clearly, good health is determined by more than money spent on the health-care system. In fact, a growing body of research indicates that living conditions - including such factors as housing quality, exposure to pollution, and access to healthy and affordable foods and safe places to exercise - have a greater effect on health. That research highlights the importance of considering health in developing policies, programs, plans, and projects, including ones that may not appear at first to have an obvious relationship to health. Health impact assessment (HIA) has arisen as an especially promising way to factor health considerations into the decision-making process. It has been defined in various ways but essentially is a structured process that uses scientific data, professional expertise, and stakeholder input to identify and evaluate public-health consequences of proposals and suggests actions that could be taken to minimize adverse health impacts and optimize beneficial ones"--Publisher's description.
  • 2005 Springer
    Hyman, David.
  • 2008 Springer
    Lamster, Ira B.; Northridge, Mary E.
    Part I: Population health and well-being -- The aging U.S. population / Steven M. Albert -- The Oral disease burden faced by older adults / Ira B. Lamster and Natalie D. Crawford -- Social disparities in oral health and health care for older adults / Luisa N. Borrell -- Access, place of residence and interdisciplinary opportunities / Janet A. Yellowitz -- Part II: Health and medical considerations -- Movement disorders in dental practice / Nina M. Browner and Steven Frucht -- Cognitive impairment / James M. Noble and Nikolaos Scarmeas -- Musculoskeletal conditions / Jennifer L. Kelsey -- Cardiovascular, cerebrovascular diseases and diabetes mellitus: co-morbidities that affect dental care for the older patient / Neerja Bhardwaj ... [et al.] -- Geriatric pharmacology: principles and implications for oral health / Brian C. Scanlan -- Management of alcohol and tobacco dependence in older adults / David A. Albert -- Part III: Oral health and dental considerations -- Normal oral mucosal, dental, periodontal, and alveolar bone changes associated with aging / Stefanie L. Russell and Jonathan A. Ship -- The relationship between periodontal disease and systemic disease in the elderly / Dana L. Wolf and Panos N. Papapanou -- Caries, tooth loss, and conventional tooth replacement for older patients / Ejvind Budtz-Jørgensen and Frauke Müller -- Implant dentistry as an approach to tooth replacement for older adults / Hans-Peter Weber -- Saliva and the salivary glands in the elderly / Louis Mandel -- Mastication, nutrition, oral health and health in older patients / Angus W.G. Walls -- Orofacial pain and neurological disorders affecting the head and neck / Ali Makki and Susan Roche -- Oral pathology affecting older adults / David J. Zegarelli, Victoria L. Woo, and Angela J. Yoon -- Part IV: Professional recommendations and future needs -- Educating the dental profession / Lynn M. Tepper -- Dental services among elderly Americans: utilization, expenditures, and their determinants / L. Jackson Brown -- Conclusion: interdisciplinary planning to meet the oral health care needs of older adults / Mary E. Northridge and Ira B. Lamster.
  • 2015 Springer
    Ganz, Patricia.
    In collaboration with the Breast Cancer Research Foundation (BCRF), this timely volume provides a comprehensive review on all areas of breast cancer survivorship research, highlighting research that is underway or in development. The range of topics covered include the biology and management of fatigue and cognitive dysfunction on breast cancer survivorship, the biology and management of Neuropathy and Arthralgias, the ongoing research on the biology of diet and lifestyle interventions in survivors, and more. With the tremendous growth in the number of breast cancer survivors, researchers have moved beyond describing the outcomes of breast cancer treatments and are focusing their research on understanding the mechanisms underlying the development of the late effects of breast cancer treatment, as well as the development and evaluation of interventions to mitigate some of the persistent symptoms--topics which are also explored in this volume. In addition, current research on how to improve survivorship and reduce recurrence of breast cancer through behavioral and lifestyle modifications is also discussed.
    Also available: Print – 2015
  • 2012
    Osheroff, Jerome A.
    PrintStatus: Not Checked OutLane Catalog Record
  • 2013 Wiley
    Davis, David A.; Eccles, Martin; Grol, Richard; Wensing, Michel.
    As innovations are constantly being developed within health care, it can be difficult both to select appropriate new practices and technologies and to successfully adopt them within complex organizations. It is necessary to understand the consequences of introducing change, how to best implement new procedures and techniques, how to evaluate success and to improve the quality of patient care. This comprehensive guide allows you to do just that. Improving Patient Care, 2nd edition provides a structure for professionals and change agents to implement better practices in health care.
  • 2010 Springer
    Bosworth, Hayden B.
    Introduction -- Physical activity and adherence -- Improving dietary adherence -- Medication adherence -- Smoking cessation and adherence -- Cancer screening adherence -- Hormonal contraceptives and adherence -- Chronic pain and adherence -- Adherence and psychotherapy -- Adherence to treatment for depression -- Adherence in the treatment of HIV and other infectious diseases -- Adherence and substance use -- Special considerations of medication adherence in childhood and adolescence -- Special considerations of adherence in older adults.
  • 2007
    Bodenheimer, Thomas; Grumbach, Kevin.
    PrintStatus: Not Checked OutLane Catalog Record
    Primary care home -- New practice model for primary care -- Patient-centered care: finding the balance -- Improving primary care for patients with chronic illness -- Self-management support for people with chronic illness -- Improving timely access to primary care -- Alternatives to the 15-minute visit -- Computerizing the primary care home -- Health care teams in primary care -- Diagnosing and treating the primary care practice -- Payment for primary care -- Conclusion -- Some organizations and resources demonstrating innovative primary care practices -- Assessing your practice -- Diagnosing problems in your practice -- Primary care patient survey -- Primary care staff satisfaction survey -- Resources on cultural competence and health literacy -- Office visit cycle time -- Interruptions in the day's work -- Group visit starter kit -- Resources available from improving chronic illness care -- Patient assessment of chronic care -- Self-management support tools -- Self-management support assessment -- Review of evidence on the chronic care model -- Review of evidence on primary care teams.
  • 2012
    Pitt, John I.
    PrintStatus: Not Checked OutLane Catalog Record
    "Mycotoxins are fungal toxins that contaminate many of the most frequently consumed foods and feeds worldwide, including staple foods consumed by many of the poorest and most vulnerable populations in the world. Therefore, human and animal exposure to one or more of this broad group of toxins is widespread. Mycotoxins have the potential to contribute to a diversity of adverse health effects in humans, including cancer, even at low concentrations. Economic burdens resulting from crop contamination are added to those on health. Given the ubiquitous nature of exposure in many countries, an urgent need exists for a coordinated international response to the problem of mycotoxin contamination of food. This book aims to sensitize the international community to the mycotoxin problem in a format that is accessible to a wide audience and is useful to decision-makers across a broad spectrum of disciplines, including agriculture, public health, marketing, and economics. The editors hope that this book will be a stimulus to governments, nongovernmental and international organizations, and the private sector to initiate measures designed to minimize mycotoxin exposure in high-risk populations. The book not only provides a scientific description of the occurrence and effects of mycotoxins but also goes further by outlining approaches to reduce mycotoxin exposure aimed at improving public health in low-income countries." -- WHO website
  • 2006 CRCnetBASE
    Buttriss, Judith; Williams, Christine M.
    pt. 1. Dietary fats and health -- pt. 2. Reducing saturated fatty acids in food -- pt. 3. Using polyunsaturated and other modified fatty acids in food products.
  • 2010
    PrintStatus: Not Checked OutLane Catalog Record
    "Civil registration systems are used to record vital events -- including births, deaths, and marriages -- and have the potential to serve as the main source of national vital statistics. However, in many developing countries, civil registration and vital statistics systems are weak or nonexistent; as a result, key demographic, fertility and mortality statistics are not available on a continuous basis and do not cover large segments of the population. A first step in addressing such weaknesses is to undertake a review of current status with a view to identifying areas requiring improvement and prioritizing actions. This package of materials -- referred to as the World Health Organization (WHO) guidance tool -- provides comprehensive guidance on how to systematically evaluate the quality and functioning of civil registration and vital statistics systems. The package consists of two components: a detailed assessment tool, plus a rapid assessment tool available as text or as a spreadsheet, for ease of compilation of data. Both tools have been extensively peer reviewed by technical experts, and field tested in three countries. The aim is to help responsible authorities obtain a clear and comprehensive understanding of the strengths and weaknesses of their civil registration and vital statistics systems, and generate the evidence base for corrective action. The detailed assessment tool reviews the main aspects of the civil registration and vital statistics systems. These include the legal and regulatory framework; registration, certification and coding practices; and the compilation, tabulation and use of the resulting data. The tool comprises both a roadmap, which outlines the main steps in conducting the review, starting with the formation of a review committee of key stakeholders, and an assessment framework, which serves as a template for the detailed review. The focus throughout is on births, deaths and causes of death, because these are the fundamental events that countries need to know about in order to guide public health programmes, monitor population dynamics and measure key health indicators. The approach described in this guidance tool is largely directed to those countries where civil registration is established but is subject to inadequacies in terms of coverage, quality or both. Countries where civil registration is not established may find the approach useful, even though not all sections of the assessment framework will be relevant. If the extent of completeness or coverage of the vital statistics data is known, even incomplete information can yield valuable insights on mortality patterns and the main causes of death. The guidance tool emphasizes the importance of critically evaluating data quality by, for example, carrying out consistency and plausibility checks, and comparing the outputs of the systems with data from other sources on mortality and fertility levels and patterns. Statisticians, health planners and others compiling and analysing vital statistics should be strongly encouraged and helped to develop such critical appraisal skills as an essential component of overall system development. Countries or local governments using these materials will be better informed about the strengths and weaknesses of their current systems, and will be able to identify the processes or aspects that need to be improved. The outcome should be improved and more useful vital statistics to support health sector reforms and development policies and programmes"--Executive summary.
  • 2008
    Small, Jacquelyn.
    PrintStatus: Not Checked OutLane Catalog Record
  • 2012 AccessMedicine
    2012 AccessEmergency Medicine
    Iserson, Kenneth V.
    "Improvised Medicine is written for healthcare providers treating patients during a crisis situation or in a primitive environment, for diseases and disorders they have little or no hands-on experience with. The book begins with situational analysis and basic needs in a crisis, then moves on to cover specific triage, diagnosis, and stabilization efforts. It then provides medical interventions for surgical and non-surgical problems"--Provided by publisher.
  • 2009
    Aboujaoude, Elias; Koran, Lorrin M.
    PrintStatus: Not Checked OutLane Catalog Record
    Compulsive buying : clinical aspects / Donald W. Black -- Compulsive buying : cultural contributors and consequences / April Lane Benson, Helga Dittmar, and Reeta Wolfsohn -- Kleptomania : clinical aspects / Lorrin M. Koran, Dana Bodnik, and Pinhas N. Dannon -- Kleptomania and the law / Brad Novak -- Pathological gambling : clinical aspects / Jon E. Grant and Brian L. Odlaug -- Pathological gambling : promoting risk, possessing ruin / Laura M. Letson -- Cash and casinos : an Indian perspective / Eileen M. Luna -- Trichotillomania : clinical aspects / Michael R. Walther, Benjamin T.P. Tucker, and Douglas W. Woods -- Trichotillomania : the view from dermatology / Drew Miller and Amy McMichael -- How to create a national advocacy organization / Christina S. Pearson -- Skin picking : clinical aspects / Celal Calikusu and Ozlem Tecer -- Skin picking : the view from dermatology / Rungsima Wanitphakdeedecha and Tina S.Alster -- Nail biting : clinical aspects / Timothy Ivor Williams -- Nail biting and other oral habits : a dental perspective / Sven E. Widmalm and Duane C. McKay -- Problematic internet use : clinical aspects / Timothy Liu and Marc N. Potenza -- Virtual violence : the games people play / Vladan Starcevic and Guy Porter -- Counseling in cyberspace : your e-therapist is on call / John H. Greist -- Hypersexuality : clinical aspects / Peer Briken, Andreas Hill, and Wolfgang Berner -- The sex industry : public vice, hidden victims / William M. Spice -- Intermittent explosive disorder : clinical aspects / Emil F. Coccaro and Michael S. McCloskey -- Violence against women : preventing a social scourge / Joan C. Chrisler and Sheila Ferguson -- Intimate partner violence : aggression at close quarters / Christy M. McKinney and Raul Caetano -- Pyromania : clinical aspects / Candice Germain and Michel Lejoyeux -- Arson : choking off the flames / Paul Schwartzman.
  • 2007 Karger
    Cavanaugh, B. D.; Meyer, John; Purdy, James A.; Timmerman, Robert D.
  • 2011 Karger
    Meyer, John.
    Over the last 4 years, IMRT, IGRT, SBRT: Advances in the Treatment Planning and Delivery of Radiotherapy has become a standard reference in the field. During this time, however, significant progress in high-precision technologies for the planning and delivery of radiotherapy in cancer treatment has called for a second edition to include these new developments. Thoroughly updated and extended, this new edition offers a comprehensive guide and overview of these new technologies and the many clinical treatment programs that bring them into practical use. Advances in intensity-modulated radiothera.
  • 2010 Springer
    Cutter, Anthony Mark; Gordijn, Bert.
    This volume assembles an interdisciplinary team of leading academics, industry figures, policymakers and NGOs to consider the legal, ethical and social issues that are raised by innovations in nanoscience and nanotechnology. By bringing together international experts from a diverse range of fields this volume addresses the implications and impact that nanotechnology has on society. Through the exploration of six key themes the contributors analyse both the impact of nanotechnology and the emergence of the concept of nanoethics. Each section includes authors from both sides of the political and scientific divide incorporating both positive and negative perspectives on nanotechnology, as well as including discussions of associated concepts such as converging technologies. The result provides for the widest and most balanced discussion of these issues to date.
  • 2007 Springer
    Flower, Darren R.; Timmis, Jonathan.
  • 2013 Springer Protocols
    Kortagere, Sandhya.
    Virtual Screening in Drug Design -- In Silico Systems Biology Approaches for the Identification of Antimicrobial Targets -- Genome Comparisons as a Tool for Antimicrobial Target Discovery -- In Silico Models for Drug Resistance -- An In Silico Model for Interpreting Polypharmacological Relationships in Drug-Target Networks -- On Exploring Structure-Activity Relationships -- Molecular Dynamics Simulations in Drug Design -- Databases and In Silico Tools for Vaccine Design -- In Silico Models for B-Cell Epitope Recognition and Signaling -- The Collaborative Drug Discovery (CDD) Database -- Recognition of Nontrivial Remote Homology Relationships Involving Proteins of Helicobacter pylori: Implications for Function Recognition -- Identification of Novel Anthrax Toxin Countermeasures Using In Silico Methods -- Rational Design of HIV-1 Entry Inhibitors -- Malarial Kinases: Novel Targets for In Silico Approaches to Drug Discovery -- Designing Novel Inhibitors of Trypanosoma brucei -- Computational Models for Tuberculosis Drug Discovery.
  • 2013 Springer Protocols
    Schneider, Maria Victoria.
    Systems biology can now be considered an established and fundamental field in life sciences. It has moved from the identification of molecular 'parts lists' for living organisms towards synthesising information from different 'omics'-based approaches to generate and test new hypotheses about how biological systems work. In Silico Systems Biology: Methods and Protocols, expert researchers in the field detail a practical set of chapters based often on actual materials used and develop for face-to-face training with examples and case studies.Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, step-by-step workflows, and key tips on troubleshooting and avoiding known pitfalls. -- Publisher website.
  • 2006 CRCnetBASE
    León, Darryl; Markel, Scott.
    Pattern matching / Scott Markel and Vinodh N. Rajapakse -- Tools for computational protein annotation and function assignment / Jaume M. Canaves -- The impact of genetic variation on drug discovery and development / Michael R. Barnes -- Mining of gene expression data / Aedin Culhane and Alvis Brazma -- Text mining / Bruce Gomes, William Hayes, and Raf Podowski -- Pathways and networks / Eric Minch and Ivayla Vatcheva -- Molecular interactions: learning from protein complexes / Ana Rojas, David de Juan, and Alfonso Valencia -- In silico siRNA design / Darryl León -- Predicting protein subcellular localization using intelligent systems / Rajesh Nair and Burkhard Rost -- Three-dimensional structures in target discovery and validation / Seán I. O'Donoghue, Robert B. Russell, and Andrea Schafferhans -- Comparative genomics / Viviane Siino, Bruce Pascal, and Christopher Sears -- Pharmacogenomics / Bahram Ghaffarzadeh Kermani -- Target identification and validation using human simulation models / Seth Michelson, Didier Scherrer, and Alex L. Bangs -- Using protein targets for in silico structure-based drug discovery / Tad Hurst -- Database management / Arek Kasprzyk and Damian Smedley -- BioIT hardware configuration / Philip Miller -- BioIT architecture: software architecture for bioinformatics research / Michael Dickson -- Workflows and data pipelines / Michael Peeler -- Ontologies / Robin A. McEntire and Robert Stevens.
    Also available: Print – 2006
  • 2011 Springer Protocols
    Hinchcliffe, Marcus; Yu, Bing.
    Accessing and selecting genetic markers from available resources / Christopher G. Bell -- Linkage analysis / Jennifer H. Barrett and M. Dawn Teare -- Association mapping / Jodie N. Painter, Dale R. Nyholt, and Grant W. Montgomery -- The ForeSee (4C) approach for integrative analysis in gene discovery / Yike Guo, Robin E.J. Munro, Dimitrios Kalaitzopoulos, and Anita Grigoriadis -- R statistical tools for gene discovery / Andrea S. Foulkes and Kinman Au -- In silico PCR analysis / Bing Yu and Changbin Zhang -- In silico analysis of the exome for gene discovery / Marcus Hinchcliffe and Paul Webster -- In silico knowledge and content tracking / Herman van Haagen and Barend Mons -- Application of gene ontology to gene identification / Hugo P. Bastos . [and others] -- Phenotype mining for functional genomics and gene discovery / Philip Groth, Ulf Leser, and Bertram Weiss -- Conceptual thinking for in silico prioritization of candidate disease genes / Nicki Tiffin -- Web tools for the prioritization of candidate disease genes / Martin Oti, Sara Ballouz, and Merridee A. Wouters -- Comparative view of in silico DNA sequencing analysis tools / Sissades Tongsima [and others] -- Mutation surveyor : an in Silico tool for sequencing analysis / Chongmei Dong and Bing Yu -- In silico searching for disease -- associated functional DNA variants / Rao Sethumadhavan, C. George Priya Doss, and R. Rajasekaran -- In silico prediction of transcriptional factor-binding sites / Dmitry Y. Oshchepkov and Victor G. Levitsky -- In silico prediction of splice-affecting nucleotide variants / Claude Houdayer -- In silico tools for qPCR assay design and data analysis / Stephen Bustin, Anders Bergkvist, and Tania Nolan -- RNA structure prediction / Stephan H. Bernhart -- In silico prediction of post-translational modifications / Chunmei Liu and Hui Li -- In silico protein motif discovery and structural analysis / Catherine Mooney [and others].
  • 2002 Springer Protocols
    Didenko, Vladimir V.
  • 2001 CRCnetBASE
    Morel, Gerard; Cavalier, Annie; Williams, Lynda.
  • 2015 Springer Protocols
    Hauptmann, Giselbert.
    Optimization of in situ hybridization and co-expression analysis in the central nervous system / Louisa Mezache ... [et al.] -- In situ hybridization methods for RNA visualization in C. elegans / Gina Broitman-Maduro and Morris F. Maduro -- Multicolored visualization of transcript distributions in Drosophila embryos / Iris Söll and Giselbert Hauptmann -- Exploring brain genoarchitecture by single and double chromogenic in situ hybridization (ISH) and immunohistochemistry (IHC) in whole-mount embryos / José Luis ... [et al.] -- Exploring brain genoarchitecture by single and double chromogenic in situ hybridization (ISH) and immunohistochemistry (IHC) on cryostat, paraffin, or floating sections / José Luis Ferran ... [et al.] -- Combined radioactive and nonradioactive double in situ hybridization (DISH) / Jong-Hyun Son and Ursula H. Winzer-Serhan -- One FISH, dFISH, three FISH : sensitive methods of whole- mount fluorescent in situ hybridization in freshwater planarians / David D. R. Brown and Bret J. Pearson -- Whole-mount in situ hybridization and immunohistochemistry in xenopus embryos / Edgar M. Pera ... [et al.] -- Manual and automated whole-mount in situ hybridization for systematic gene expression analysis in embryonic Zebrafish forebrain / Iris Söll and Giselbert Hauptmann -- Large-scale ISH on mouse brain sections for systematic gene expression analysis in developing mouse diencephalon / Tomomi Shimogori and Seth Blackshaw -- High-throughput in situ hybridization : systematical production of gene expression data and beyond / Lars Geffers and Gregor Eichele -- Analysis of embryonic gene expression patterns in the hagfish / Yasuhiro Oisi ... [et al.] -- Gene expression analysis of lamprey embryos / Fumiaki Sugahara, Yasunori Murakami, and Shigeru Kuratani -- Detection of mRNA and microRNA expression in basal chordates, amphioxus and ascidians / Simona Candiani, Greta Garbarino, and Mario Pestarino -- Analysis of gene expression in neurons and synapses by multi-color in situ hybridization / Leonid L. Moroz and Andrea B. Kohn -- Fluorescent in situ hybridization in primary hippocampal neurons to detect localized mRNAs / Jacki E. Heraud-Farlow, Tejaswini Sharangdhar, and Michael A. Kiebler -- Combining whole-mount in situ hybridization with neuronal tracing and immunohistochemistry / Jeremy S. Duncan ... [et al.] -- Fluorescent in situ hybridization detection of microRNAs in Newt tissue cryosections / Jamie Ian Morrison -- Subcellular transcript localization in Drosophila embryos and tissues visualized by multiplex-FISH / Julie Bergalet ... [et al.] -- Application of alkaline phosphatase-mediated azo dye staining for dual fluorescent in situ hybridization in Zebrafish / Giselbert Hauptmann, Gilbert Lauter, and Iris Söll -- Multiplex fluorescent RNA in situ hybridization via RNAscope / Hongwei Wang ... [et al.] -- Quantum dot-based in situ hybridization and immunohistochemistry to detect mRNA and protein at subcellular levels, comparison with studies using electron microscopy / Akira Matsuno ... [et al.] -- Quantitative multiplexed quantum dot based in situ hybridization in formalin-fixed paraffin-embedded tissue / Eleni Tholouli, Judith A. Hoyland, and Richard J. Byers -- Single and multiplexed fluorescent in situ hybridization using quantum dots nanocrystals in xenopus / Andriani Ioannou ... [et al.] -- Quantitative single-molecule mRNA fluorescent in situ hybridization in C. elegans / Remco A. Mentink ... [et al.] -- In situ detection of individual mRNA molecules with padlock probes and target-primed rolling-circle amplification in fixed mouse brain tissues / Thomas Hauling ... [et al.] -- Extended multiplexed fluorescent in situ hybridization by combinatorial encoding of individual transcripts / Lars Martin Jakt and Satoko Moriwaki -- Characterizing cellular identity at one cell resolution / Amaresh K. Ranjan, Mugdha V. Joglekar, and Anandwardhan A. Hardikar -- Transglutaminase-mediated in situ hybridization (TransISH) for mRNA detection in mammalian tissues / Katsuyuki Miyawaki, Sumihare Noji, and Noriho Kamiya -- ECHO-FISH for gene transcript detection in neuronal and other cells and subcellular compartments / Dan Ohtan Wang and Akimitsu Okamoto.
  • 2005 Springer Protocols
    Darby, Ian A.; Hewitson, Tim D.
    In situ hybridization using riboprobes on free-floating brain sections / Neil C. Owens, F. Martin Hess, and Emilio Badoer -- An in situ hybridization technique to detect low-abundance slug mRNA in adherent cultured cells / Changsun Choi ... [et al.] -- Identification of transplanted human cells in animal tissues / Daniel Benten, Kang Cheng, and Sanjeev Gupta -- In situ hybridization to plant tissues and chromosomes / Andreas Houben, Sharon J. Orford, and Jeremy N. Timmis -- Histochemical localization of cell proliferation using in situ hybridization for histone mRNA / Tim D. Hewitson, Kristen J. Kelynack, and Ian A. Darby -- Histochemical localization of apoptosis with in situ labeling of fragmented DNA / Tim D. Hewitson, Teresa Bisucci, and Ian A. Darby -- Nonradioactive in situ hybridization on frozen sections and whole mounts / Julia Asp, Alexandra Abramsson, and Christer Betsholtz -- In situ hybridization of whole mount embryos / Murray Hargrave, Josephine Bowles, and Peter Koopman -- In situ detection of Epstein-Barr virus and phenotype determination of EBV-infected cells / Gerald Niedobitek and Hermann Herbst -- PNA- situ hybridization method for detection of HIV-1 DNA in virus-infected cells and subsequent detection of cellular and viral proteins / Tomoko Hagiwara, Junko Hattori, and Tsuguhiro Kaneda -- Electron microscopy and in situ hybridization: expression of P2Y2 receptor mRNA in the cerebellum / Andrzej Loesch and Rainer Glass -- The use of combined immunohistochemical labeling and in situ hybridization to colocalize mRNA and protein in tissue sections / Malcolm D. Smith, Michael Ahern, and Mark Coleman -- Semiquantitative in situ hybridization using radioactive probes to study gene expression in motoneuron populations / Paul D. Storer and Tracey DeLucia -- Quantitative in situ hybridization of tissue microarrays / Adrian M. Jubb ... [et al.]. Treatment of tissue sections for in situ hybridization / Gregory H. Tesch, Hui Y. Lan, and David J. Nikolic-Paterson -- Preparation of template DNA and labeling techniques / Peter J. Roche -- In situ hybridization using cRNA probes: isotopic and nonisotopic detection methods / Ian A. Darby ... [et al.] -- Tyramide signal amplification for DNA and mRNA in situ hybridization / Ernst J.M. Speel, Anton H.N. Hopman, and Paul Komminoth -- Expression analysis of murine genes using in situ hybridization with radioactive and nonradioactively labeled RNA probes / Anne Chotteau-Lelièvre, Pascal Dollé, and Françoise Gofflot --
  • 2013 Springer
    Artenstein, Andrew W.
    1. Origins -- 2. The Art and Science of Germs -- 3. A Singular Disease -- 4. A Very Mortal Disease -- 5. Early Approaches at Therapy -- 6. Antibiotics and Survival of the Fittest -- 7. A Brief History of Vaccines -- 8. That Soluble Specific Substance -- 9. Towards a Vaccine -- 10. Success for Half -- 11. The Future of a Killer.
  • 2009
    Papadatou, Danai.
    Society, science, and death -- A relationship of care -- Distinct features of the helping relationship -- The accompanying process -- The wounded healer -- A model for professionals' grieving process -- The rewards of caregiving -- Caregiving organizations and death -- Team functioning in death situations -- The good-enough team -- The challenges of educating health care professionals -- Epilogue -- Appendix: Brief description of Bowlby's theory on attachment.
  • 2013
    Edwards, Laurie.
    PrintStatus: Not Checked OutLane Catalog Record
    "Thirty years ago, Susan Sontag wrote, "Everyone who is born holds dual citizenship in the kingdom of the well and the kingdom of the sick ... Sooner or later each of us is obliged, at least for a spell, to identify ourselves as citizens of that other place." Now more than 133 million Americans live with chronic illness, accounting for nearly three-quarters of all health care dollars, and untold pain and disability. There has been an alarming rise in illnesses that defy diagnosis through clinical tests or have no known cure. Millions of people, especially women, with illnesses such as irritable bowel syndrome, chronic pain, and chronic fatigue syndrome face skepticism from physicians and the public alike. And people with diseases as varied as cardiovascular disease, HIV, certain cancers, and type 2 diabetes have been accused of causing their preventable illnesses through their lifestyle choices. We must balance our faith in medical technology with awareness of the limits of science, and confront our throwback beliefs that people who are sick have weaker character than those who are well. Through research and patient narratives, health writer Laurie Edwards explores patient rights, the role of social media in medical advocacy, the origins of our attitudes about chronic illness, and much more. What The Noonday Demon did for people suffering from depression, In the Kingdom of the Sick does for those who are chronically ill"--Provided by publisher.
  • 2013 ebrary
    Horowitz, Ruth.
    Public member, researcher, and public sociologist -- How licensure became a medical institution -- The Federal bureaucracy starts a public dialogue -- The state, the media, and the shaping of public opinion -- Rhetorics of law, medicine, and public interest shape board work -- Medical and legal discourses in investigatory committees -- Hearing and sanction deliberations : transparency and fact construction issues -- Democratic deliberation and public interest.
  • 2008 Springer
    Blaszczynski, Alex; Turner, Nigel E.; Zangeneh, Masood.
    Introduction / Masood Zangeneh, Alex Blaszczynski and Nigel E. Turner -- Explaining Why People Gamble / Michael Walker, Tony Schellink, and Fadi Anjoul -- Games, Gambling, and Gambling Problems / Nigel E. Turner -- Exploring the Mind of the Gambler / Ewa Czerny, Stephanie Koenig, and Nigel E. Turner -- Individual Factors in the Development and Maintenance of Problem Gambling / Masood Zangeneh, Alex Grunfeld, and Stephanie Koenig -- Gambling / Lisa Cavion, Carol Wong, and Masood Zangeneh -- A Critical Perspective on Gambling / Amnon Jacob Suissa -- The Marketing of Gambling / Masood Zangeneh, Mark Griffiths, and Jonathan Parke -- Religiosity and Gambling Rituals / Robert Grunfeld, Masood Zangeneh, and Lea Diakoloukas -- Buying a Risk / G. E. Minchin -- Cognitive Behavioral Therapy for Problem Gamblers / Malcolm Battersby, Jane Oakes, Barry Tolchard, Angus Forbes, and Rene Pols -- Psychopharmacological Management of Pathological Gambling / Jon E. Grant, Suck Won Kim, and Marc N. Potenza -- A Transpersonal Developmental Approach to Gambling Treatment / Gary Nixon and Jason Solowoniuk -- How Science Can "Think" About Gamblers Anonymous / Peter Ferentzy and Wayne Skinner -- Problem Gambling and Anger: Integrated Assessment and Treatment / Lorne M. Korman, Emily Cripps, and Tony Toneatto -- A Treatment Approach for Adolescents with Gambling Problems / Rina Gupta and Jeffrey Derevensky -- The Evolution of Problem Gambling Helplines / Gary Clifford.
  • 2012
    Zhang, Huibin; Brunet, Anne; Fire, Andrew Z.; Li, Jin; Villeneuve, Anne.
    MicroRNAs are an important class of short RNA molecules that regulate gene expression in diverse organisms. Despite their short history, extensive research on microRNAs has revealed how microRNAs are made, their regulatory mechanisms and functions in different biological processes. In addition, novel experimental techniques and computational algorithms have been developed to study microRNAs. Our knowledge of microRNAs is constantly evolving as newer studies turn up exceptions to canonical models established by early studies. This highlights how our understanding of microRNAs is far from complete and much work is still needed to investigate unexplored aspects of the microRNA world. The founding microRNAs, C. elegans lin-4 and let-7, have well-characterized heterochronic defects in mutant animals and their target genes have been genetically validated. Combined with powerful experimental tools available in C. elegans, the microRNA function of lin-4 and let-7 in developmental timing of C. elegans is an ideal in vivo model system for testing microRNA-related hypotheses. Using functional assays to evaluate lin-4 and let-7 rescue activities in transgenic animals, we have investigated several poorly understood aspects of microRNAs, from biogenesis to functional mechanism. In this work, we first demonstrated the cell autonomous nature of lin-4 in C. elegans temporal development. Through tissue/cell-specific expression of lin-4 and the use of tissue/cell-specific reporters and microRNA sponges, we have shown that lin-4 rescue activities were limited to sites of lin-4 expression, despite its broad endogenous expression and function in many tissues. Next, we showed that intron-containing microRNAs ("inc-miRs") are functional in C. elegans, raising the possibility that mature microRNAs need not be encoded as contiguous units in the genome. This result also highlights a blindspot in our current novel microRNA discovery methods that assume inc-miRs do not exist. Lastly, we investigated the partnership between microRNA "seed" and "non-seed" sequences in providing microRNA function during C. elegans temporal development. By assessing microRNA function in transgenic mutant animals expressing lin-4 or let-7 mutant microRNA, we found contrasting results between lin-4 and let-7. While the results suggest a functional requirement for lin-4 seed sequence, mutations in either let-7 seed or non-seed sequences provided similar levels of functional activities. Using C. elegans lin-4 and let-7 as an experimental model, this work has furthered our understanding on microRNA autonomy, microRNA biogenesis and functional partnership between microRNA seed and non-seed sequence.
  • 2011
    Meyer, Carissa Bove; Pfeffer, Suzanne R.; Straight, Aaron; Theriot, Julie A.
    Eukaryotic chromosomes segregate by attaching to microtubules of the mitotic spindle through a chromosomal microtubule-binding site called the kinetochore. Kinetochores assemble on a specialized chromosomal locus termed the centromere, characterized by the replacement of histone H3 in centromeric nucleosomes with the essential histone H3 variant centromere protein A (CENP-A). CENP-A nucleosomes are believed to epigenetically specify centromere identity, thus understanding how CENP-A chromatin is assembled and maintained is central to understanding chromosome segregation mechanisms. CENP-A nucleosome assembly requires the Mis18 complex and the CENP-A chaperone HJURP. HJURP binds to pre-nucleosomal CENP-A and facilitates the deposition of new CENP-A nucleosomes into centromeric chromatin. The mechanistic roles of the Mis18 complex in CENP-A assembly and maintenance are not well understood. The Mis18 complex and HJURP localize to centromeres in telophase/G1, when new CENP-A chromatin is assembled. The molecular interactions that control their targeting are unknown. Several constitutive centromere proteins that remain associated with CENP-A chromatin throughout the cell cycle have also been implicated in CENP-A assembly, including CENP-C. Their functions in CENP-A assembly are unknown. The first chapter of this thesis work describes the development of an in vitro system for centromeric chromatin assembly in Xenopus laevis egg extracts. We show that CENP-A assembly in extract recapitulates the cell cycle dependence and HJURP requirement of CENP-A assembly in somatic cells. We then use this in vitro system to identify a novel role for CENP-C in recruiting CENP-A assembly factors to the centromere to promote CENP-A assembly, described in Chapter 2. We show that CENP-C is required to target the Mis18 complex protein M18BP1 to Xenopus sperm centromeres in metaphase. In the absence of CENP-C, M18BP1 and HJURP targeting to centromeres is disrupted and new CENP-A assembly into centromeric chromatin is inhibited. We find that CENP-C interacts directly with M18BP1 through conserved domains in the CENP-C protein. Thus, CENP-C provides a link between existing CENP-A chromatin and the proteins required for new CENP-A nucleosome assembly. Overall, this work extends our mechanistic understanding of how the pre-existing centromere directs the local assembly of new CENP-A nucleosomes to ensure stable propagation of the centromere. Furthermore, the ability to assemble centromeric chromatin in vitro will provide a valuable tool for dissecting the biochemical and cell cycle regulatory mechanisms that control new CENP-A assembly and ensure faithful centromere propagation.
  • 2010
    Chen, Michael Quay; Kovacs, Gregory T. A.; Smolke, Christina D.; Wu, Joseph C.
    The limited ability of the human heart to regenerate has made myocardial infarction and heart failure debilitating conditions. Recently, an approach using pluri- or multi-potent stem cells to repair damaged heart tissue is being explored for its potential to regenerate tissue as a tailored, patient-specific treatment. However, the mechanisms of integration remain unclear, and many cardiac grafting procedures utilizing both embryonic and adult stem cells have been met with limited success. While current evidence suggests that grafts are likely viable in host myocardium, clinical studies have reported pro arrhythmic side-effects following transplantation, which arise from disrupted propagation patterns. These issues may be attributed to grafts lacking cardiac differentiation, or possessing conduction properties inconsistent with the host tissue. Consequently, understanding the role of the electrical environment throughout the engraftment process is necessary, but infeasible due to a lack of proper tools. Elucidating the electrical aspects of stem cell transplantation aims to ensure proper integration of the transplanted cells to prevent aberrant electrical pathways in the heart. In this work, a set of in vitro tools were developed to study the potential mechanisms underlying the risk of arrhythmia following stem cell transplantation. A planar microelectrode array was first used to investigate the possibility of conduction block if undifferentiated or non cardiomyocyte stem cells, such as mesenchymal stem cells, are used as grafts. Conduction in murine cardiomyocytes was purposely blocked by co-culture with non-conducting murine fibroblasts, and a novel mathematical transform known as a co occurrence matrix was developed to quantitatively analyze the uniformity of conduction. The observed sensitivity of cardiomyocyte conduction illustrated the risk of grafting non-cardiomyocyte cell types despite any potential of differentiating into muscle-like cells. Unlike non-conducting fibroblasts, stem cell grafts are expected to electrically conduct if proper cardiac differentiation takes place. However, possible differences in the conduction properties of these grafts may still lead to arrhythmia. To perform a controlled study of such conduction mismatch, an in vitro co-culture system coupled to microelectrode arrays was developed. Spatially separated cultures representing the host and the graft were allowed to gradually merge above the microelectrode array, allowing the measurement of conduction throughout the integration process. Modeled host and graft cell populations were evaluated by analyzing the co occurrence matrix and conduction velocity for the quality and speed of conduction over time. Co cultures between murine cardiomyocytes (host) and murine skeletal myoblasts (graft) exhibited significant differences in conduction despite synchronous electrical activity. In contrast, conduction was well matched when the same host cells were co cultured with murine embryonic stem cells (mESC). A model using murine cardiomyocytes (host) and differentiating human embryonic stem cells (graft) allowed the characterization of conduction properties relevant to current trans-species animal models, and demonstrate the co-culture device as a screening platform for candidate graft cells. The limited region of the graft that supported conduction exhibited differences in the co-occurrence matrix as well as conduction velocity when compared to the host region. In an effort to improve the effects of conduction mismatch, both host and graft cell populations were electrically paced over the length of time the cultures remained viable (4-5 days). Although a difference between conduction velocities between host and graft was still observed, the overall uniformity of conduction improved in paced co-cultures, implying increased cardiac differentiation. A preliminary study of genomic changes due to paced mESCs resulted in a significant upregulation of several important cardiac genes and a significant downregulation of many embryonic genes. Further efforts are currently underway to examine gene expression with paced hESCs to optimize integration in the host-graft model, and ultimately to understand how the electrical environment influences stem cell transplantation.
  • 2012 Springer
    Ginsburg, Elizabeth S.; Racowsky, Catherine.
    In Vitro Fertilization: A Comprehensive Guide represents the next frontier in the integrated clinical and laboratory practice of ART. Uniquely balanced, the book provides the necessary understanding of the key laboratory techniques involved in ART and the complex aspects of clinical care. Featuring the contributions of world leaders in the field, the guide begins with the evaluation of the infertile woman and man. It then moves on to discuss treatment protocols and adjunctive treatments. Techniques for oocyte retrieval and insemination, embryo culture and transfer, and micromanipulation procedures are explored in detail. This comprehensive book covers all aspects of IVF and includes special sections on oocyte and embryo donation as well as gestational carriers, making it ideal for practicing clinicians. Advances such as pre-implantation genetic diagnosis and screening, in vitro maturation, and means of fertility preservation, including oocyte and ovarian tissue cryopreservation, are also covered. The book concludes with dedicated chapters on quality assessment and improvement, regulation and legal concerns, and stress and ART. Readers will gain complete in-depth knowledge of the most current therapies and techniques, enabling optimal care and counsel of their infertile patients.
  • v. 1-<5>, 1986-<88>
    Sekely, Lea I.; Webber, Mukta M.
    PrintStatus: Not Checked OutLane Catalog Record
    v. 1. Carcinomas of the esophagus and colon.--v. 2. Carcinomas of the liver and pancreas.--v. 3. Carcinomas of the mammary gland, uterus, and skin.--v. 4. Carcinomas of the urinary bladder and kidney.--v. 5. Carcinoma of the prostate and testis.
  • 2010 Springer Protocols
    Braman, Jeff.
    Mutagenesis protocols in Saccharomyces cerevisiae by in vivo overlap extension / Mibuel Alcalde -- In vitro mutagenesis of Brucella species / Thomas A. Ficht, Jianwu Pei, and Melissa Kahl-McDonagh -- Random mutagenesis strategies for Campylobacter and Helicobacter species / Duncan J.H. Gaskin and Arnoud H.M. van Vliet -- Mutagenesis of the repeat regions of herpesviruses cloned as bacterial artificial chromosomes / Yuguang Zhao and Venugopal Nair -- An efficient protocol for VZV BAC-based mutagenesis / Zhen Zhang, Ying Huang, and Hua Zhu -- A method for rapid genetic integration into Plasmodium falciparum utilizing mycobacteriophage Bxb1 integrase / Sophie H. Adjalley, Marcus C.S. Lee, and David A. Fidock -- Random mutagenesis by error-prone PCR / Elizabeth O. McCullum ... [et al.] -- A rapid and versatile PCR-based site-directed mutagenesis protocol for generation of mutations along the entire length of a cloned cDNA / Vincent Dammai -- Rapid sequence scanning mutagenesis using in silico oligo design and the megaprimer PCR of whole plasmid method (MegaWhop) / Urich Krauss, Karl-Erich Jaeger, and Thorsten Eggert -- Insertion and deletion mutagenesis by overlap extension PCR / Jehan Lee ... [et al.] -- Targeted amplification of mutant strands for efficient site-directed mutagenesis and mutant screening / Lei Young and Qihan Dong -- A modified inverse PCR procedure for insertion, deletion, or replacement of a DNA fragment in a target sequence and its application in the ligand interaction scan method for generation of ligand-regulated proteins / Oran Erster and Moti Liscovitch -- Amplification of orthologous genes using degererate primers / Samya Chakravorty and jim O. Vigoreaux -- Computational evaluation of protein stability change upon mutations / Shuangye Yin, Feng Ding, and Nikolay V. Dokholyan -- Approaches for using animal models to identify loci that genetically interact with human disease-causing point mutations / Josef D. Franke -- Using peptide loop insertion mutagenesis for the evolution of proteins / Christian Heinis and Kai Johnsson -- Massive mutagenesis : high-throughput combinatorial site-directed mutagenesis / Julien Sylvestre -- Directed in vitro evolution of reporter genes based on semi-rational design and high-throughput screening / Ai-Sheng Xiong ... [et al.] -- Ribosome display for rapid protein evolution by consecutive rounds of mutation and selection / Hayato Yanagida, Tomoaki Matsuura, and Tetsuya Yomo -- Fine-tuning enzyme activity through saturation mutagenesis / Holly H. Hogrefe -- Characterization of structural determinants of type 1 corticotropin releasing hormone (CRH) receptor signalling properties / Danijela Markovic and Dimitris K. Grammatopoulos -- Site-directed mutagenesis for improving biophysical properties of Vh domains / Mehdi Arbabi-Ghahroudi, Roger MacKenzie, and Jamshid Tanha -- Phenotype based functional gene screening using retrovirus-mediated gene trapping in quasi-haploid RAW 264.7 cells / Sung Ouk Kim and Soon-Duck Ha -- Site-directed disulfide cross-linking to probe conformational changes of a transporter during its functional cycle : Escherichia coli AcrB multidrug exporter as an example / Yumiko Takatsuka and Hiroshi Nikaido -- Site-specific incorporation of extra components into RNA by transcription using unnatural base pair systems / Michiko Kimoto and Ichiro Hirao -- Mutagen : a random mutagenesis method providing a complementary diversity generated by human error-prone DNA polymerases / Philippe Mondon ... [et al.] -- Random-scanning mutagenesis / Robert A. Smith -- Easy two-step method for randomizing and cloning gene fragments / Vivan Q. Zhang and Holly H. Hogrefe -- Random mutagenesis using a mutator strain / Ghazala Muteeb and Ranjan Sen -- En passant mutagenesis : a two step markerless red recombination system / B. Karsten Tischer, Gregory A. Smith, and Nikolaus Osterrieder.
  • 2011 Springer Protocols
    Costa, Lucio G.; Giordano, Gennaro; Guizzetti, Marina.
    In vitro neurotoxicology : an introduction / Lucio G. Costa, Gennaro Giordano, and Marina Guizzetti -- Primary neurons in culture and neuronal cell lines for in vitro neurotoxicological studies / Gennaro Giordano and Lucio G. Costa -- Determination of metal interactions with the chaperone Hspa5 in human astrocytoma cells and rat astrocyte primary cultures / Evelyn Tiffany-Castiglioni [and others] -- Microglia cell culture: a primer for the novice / Anke Witting and Thomas Möller -- Neural stem cells for developmental neurotoxicity studies / Roshan Tofighi [and others] -- Preparation, maintenance, and use of serum-free aggregating brain cell cultures / Paul Honegger [and others] -- Neurospheres as a model for developmental neurotoxicity testing / Ellen Fritsche, Kathrin Gassmann, and Timm Schreiber -- Acute hippocampal slice preparation and hippocampal slice Cultures / Pamela J. Lein, Christopher D. Barnhart, and Isaac N. Pessah -- Glia-neuron sandwich cocultures : an in vitro approach to evaluate cell-to-cell communication in neuroinflammation and neurotoxicity / ariaserena Boraso and Barbara Viviani -- In vitro models to study the blood brain barrier / Hilary Vernon, Katherine Clark, and Joseph P. Bressler -- Measurements of cell death in neuronal and glial cells / Gennaro Giordano [and others] -- Measurements of neuronal apoptosis / Gennaro Giordano and Lucio G. Costa -- Measurement of isoprostanes as markers of oxidative stress / Dejan Milatovic, Thomas J. Montine, and Michael Aschner -- Assessment of glutathione homeostasis / Gennaro Giordano, Collin C. White, and Lucio G. Costa -- Assessing neuronal bioenergetic status / Stephanie L.H. Zeiger, Jeannette N. Stankowski, and BethAnn McLaughlin -- Fluorescent assessment of intracellular calcium in individual cells / David P. Cox, Collin C. White, and Terrance J. Kavanagh -- Homeostatic regulation of glutamate neurotransmission in primary neuronal cultures / Victor Briz and Cristina Suñol -- Detection of nitric oxide formation in primary neural cells and tissues / Ronald B. Tjalkens, David L. Carbone, and Guoyao Wu -- JNK3-mediated apoptotic cell death in primary dopaminergic neurons / Won-Seok Choi, Heather M. Klintworth, and Zhengui Xia -- Measurement of proteasomal dysfunction in cell models of dopaminergic degeneration / Faneng Sun, Anumantha G. Kanthasamy, and Arthi Kanthasamy -- Cell signaling and neurotoxicity : protein kinase C in vitro and in vivo / Prasada Rao S. Kodavanti -- Cell signaling and neurotoxicity : 3H-arachidonic acid release (phospholipase A2) in cerebellar granule neurons / Prasada Rao S. Kodavanti -- Quantitative assessment of neurite outgrowth in PC12 cells / Joshua A. Harrill and William R. Mundy -- Measurements of astrocyte proliferation / Marina Guizzetti, Terrance J. Kavanagh, and Lucio G. Costa -- Quantification of synaptic structure formation in cocultures of astrocytes and hippocampal neurons / Pamela J. Roqué [and others] -- Volume measurements in cultured primary astrocytes / Michael Aschner -- Assessment of cholesterol homeostasis in astrocytes and neurons / Jing Chen, Lucio G. Costa, and Marina Guizzetti -- Dose-response or dose-effect curves in in vitro experiments and their use to study combined effects of neurotoxicants / Matteo Goldoni and Sara Tagliaferri.
  • 2007/2008
    Wrenn, Stephen Jarrett.
    PrintStatus: Not Checked OutLane Catalog Record
  • 2014 Springer Protocols
    Bal-Price, Anna; Jennings, Paul.
    In Vitro Toxicology Systems brings together important issues and considerations needed in order to develop a workable, reliable, integrated testing strategy for the replacement of animals in toxicity testing regimes. This thorough volume includes sections on in vitro models for systemic organ toxicity, neurotoxicity, sensory organs, immunotoxicity and reproductive toxicity and addresses how stem cells may be used going forward. The book also tackles difficult areas of toxicology such as carcinogenicity and nanotoxicology, with additional chapters dedicated to kinetics, metabolism, and in vitro in vivo extrapolation. The book also addresses biological processes such as stress response pathways and mechanistic biomarkers and how these can be uncovered and measured using high content approaches. Reliable and authoritative, In Vitro Toxicology Systems will be of benefit not only to students, scientists, and regulators working in the field of chemical safety assessment but also to a wider scientific audience.
  • 2007 Springer Protocols
    Grandi, Guido.
    Energy systems for ATP regeneration in cell-free protein synthesis reactions / Kara A. Calhoun and James R. Swartz -- Continuous-exchange protein-synthesizing systems / Vladimir A. Shirokov ... [et al.] -- Cell-free production of integral membrane proteins on a preparative scale / Christian Klammt ... [et al.] -- SIMPLEX : a novel method for high-throughput construction and screening of protein libraries / Suang Rungpragayphan, Tsuneo Yamane, and Hideo Nakano -- Methods for high-throughput materialization of genetic information based on the wheat germ cell-free expression system / Tatsuya Sawasaki ... [et al.] -- Exogenous protein expression in Xenopus oocytes : basic procedures / Elena Bossi ... [et al.] -- In vitro translation to study HIV protease activity / Zene Matsuda ... [et al.] -- The protein truncation test in mutation detection and molecular diagnosis / Oliver Hauss and Oliver Muller -- Creation of novel enantioselective lipases by SIMPLEX / Yuichi Koga, Tsuneo Yamane, and Hideo Nakano -- In vitro transcription and translation coupled with two-dimensional electrophoresis for bacterial proteome analysis / Nathalie Norais ... [et al.] -- In vitro screen of bioinformatically selected Bacillus anthracis vaccine candidates by coupled transcription, translation, and immunoprecipitation analysis / Orit Gat, Haim Grosfeld, and Avigdor Shafferman -- Functional expression of Type 1 rat GABA transporter in microinjected Xenopus laevis oocytes / Stefano Giovannardi ... [et al.] -- Production of protein for nuclear magnetic resonance study using the wheat germ cell-free system / Toshiyuki Kohno and Yaeta Endo.
  • 2012
    Gracey, Lia; Baker, Julie C.; Fire, Andrew Z.; Ford, James; Kay, Mark A.; Wysocka, Joanna.
    The pursuit of gene therapy to treat a wide-spectrum of diseases holds great promise, but its application in the clinic is still blocked by several barriers. Gene therapy approaches that rely on a virus to carry genetic material are plagued by problems with a host immune response and difficulty reaching therapeutic doses. Nonviral approaches have the advantage that delivering naked DNA does not illicit the same significant immune response and therapeutic levels are often initially easily attained. But, one prominent barrier to nonviral gene therapy is the lack of in vivo sustained expression from a foreign transgene. In the early stages after delivery, robust expression can be achieved from transgenic DNA, but this expression is very quickly and efficiently silenced, with loss of the desired effect of gene replacement. Our work took a two-step approach to further our understanding of how to create a better expression vector, both for gene therapy purposes as well as basic scientific goals of sustaining expression from delivered transgenic DNA. First, we studied whether we could manipulate and control the chromatin structure that a delivered gene adopts in vivo via nucleosome positioning signals on plasmid DNA in mouse liver. We developed a selective hybridization assay that allowed us to use a high-throughput sequencing approach to more rapidly screen the nucleosome occupancy and positioning of numerous constructs with varied DNA elements. We were able to transiently control the initial chromatin structure, but other forces in the cell soon overcame the thermodynamic preferences of nucleosome formation. We now believe that the use of nucleosome eviction elements may be a more promising approach: it will likely be more feasible to exclude nucleosome formation using rigid DNA sequences instead of permanently positioning a nucleosome using DNA sequence alone. Secondly, we gained a more fundamental understanding of the mechanism(s) responsible for the silencing of episomal (non-integrating) DNA constructs in mouse liver. We studied the differences between plasmid DNA and minicircle DNA, which was derived from a parental plasmid but lacked bacterial backbone sequences. At 6 weeks after delivery, plasmid DNA was effectively silenced but there was still active expression from the minicircle. We used high-throughput sequencing approaches to quantitate the levels of transcription and the enrichment of various histone modifications and RNA polymerase II (Pol II) on plasmid and minicircle. We found that Pol II appeared to stall at the transcription start site on the plasmid but was present at the 5' and 3' ends of the gene on the minicircle. This observation may explain the 28-fold higher level of transcript produced by the minicircle versus the plasmid. Though we saw enrichment of activating and silencing histone modifications on both plasmid and minicircle (likely due to our analysis of a population of cells which at any given point could have a construct that is actively expressed or silenced) we observed a striking abundance of a well-characterized histone modification associated with silencing on the plasmid and not on the minicircle. These results represent a contribution to the fields of gene therapy and chromatin biology that will help us move in the direction of achieving safe, therapeutic, and sustained expression of transgenic DNA.
  • 2007 Springer
    Price, Pat; Shields, Anthony Frank.
  • 2006 Springer
    Bendinelli, Mauro; Friedman, Herman; Specter, Steven.
  • v. 1-2, 2006. Springer
    Marshall, Lisa A.; Morgan, Douglas W.; Stevenson, Christopher S.
    Also available: Print – v. 1-2., 2006
  • 2011 Springer Protocols
    Faber, Cornelius; Schröder, Leif.
    Physical basics of NMR / Rolf Pohmann -- Spatial encoding-basic imaging sequences / Rolf Pohmann -- Basic contrast mechanisms / Leif Schröder and Cornelius Faber -- Scanner components / Volker C. Behr -- Small animal preparation and handling in MRI / Patrick McConville -- Cerebral perfusion MRI in mice / Frank Kober, Guillaume Duhamel, and Virginie Callot -- High field diffusion tensor imaging in small animals and excised tissue / Bernadette Erokwu, Chris Flask, and Vikas Gulani -- BOLD effect / Joan M. Greve -- Screening of CEST MR contrast agents / Xiaolei Song, Kannie W.Y. Chan, and Michael T. McMahon -- Hyperpolarized noble gases as contrast agents / Xin Zhou -- Hyperpolarized molecules in solution / Jan Henrik Ardenkjaer-Larsen .. [et al.] -- MR oximetry / Jeff F. Dunn -- MRI using intermolecular multiple-quantum coherences / Rosa Tamara Branca -- Experimental stroke research : the contributions of in vivo MRI / Therése Kallur and Mathias Hoehn -- Volumetry and other quantitative measurements to assess the rodent brain / Alize Scheenstra, Jouke Dijkstra, and Louise van der Weerd -- Models of neurodegenerative disease -- Alzheimer's anatomical and amyloid plaque imaging / Alexandra Petiet, Benoit Delatour, and Marc Dhenain -- MRI in animal models of psychiatric disorders / Dana S. Poole, Melly S. Oitzl, and Louise van der Weerd -- Spectroscopic imaging of the mouse brain / Dennis W.J. Klomp and W. Klaas Jan Renema -- Spinal cord -- MR of rodent models / Virginie Callot, Guillaume Duhamel, and Frank Kober -- Assessment of global cardiac function / Jürgen E. Schneider -- Plaque imaging in murine models of cardiovascular disease / Gert Klug, Volker Herold, and Karl-Heinz Hiller -- Interventional MRI in the cardiovascular system / Harald H. Quick -- MR for the investigation of murine vasculature / Christoph Jacoby and Ulrich Flögel -- MRI of the lung : non-invasive protocols and applications to small animal models of lung disease / Magdalena Zurek and Yannick Crémillieux -- Characterization of tumor vasculature in mouse brain by USPIO contrast-enhanced MRI / Giulio Gambarota and William Leenders -- Cancer models-multiparametric applications of clinical MRI in rodent hepatic tumor model / Feng Chen, Frederik De Keyzer, and Yicheng Ni -- BOLD MRI applied to a murine model of peripheral artery disease / Joan M. Greve -- Manganese-enhanced magnetic resonance imaging / Susann Boretius and Jens Frahm -- Spin echo BOLD fMRI on songbirds / Colline Poirier and Anne-Marie Van der Linden -- MRI to study embryonic development / Bianca Hogers -- Mouse phenotyping with MRI / X. Josette Chen and Brian J. Nieman -- Analysis of freshly fixed and museum invertebrate specimens using high-resolution, high-throughput MRI / Alexander Ziegler and Susanne Mueller -- Applications of hyperpolarized agents in solutions / Jan Henrik Ardenkjaer-Larsen [and others] -- Target-specific paramagnetic and superparamagnetic micelles for molecular MR imaging / Roel Straathof, Gustav J. Strijkers, and Klaas Nicolay -- Tracking transplanted cells by MRI- methods and protocols / Michel Modo -- MRI of CEST-based reporter gene / Guanshu Liu and Assaf A. Gilad.
  • 2009 CRCnetBASE
    Frostig, Ron D.
    Optical imaging of brain activity in vivo using genetically encoded probes / Matt Wachowiak and Thomas Knöpfel -- Two-photon functional imaging of neuronal activity / Fritjof Helmchen -- In vivo two-photon laser scanning microscopy with concurrent plasma-mediated ablation : principles and hardware realization / Philbert S. Tsai and David Kleinfeld -- MPScope 2.0 : a computer system for two-photon laser scanning microscopy with concurrent plasma-mediated ablation and electrophysiology / Quoc-Thang Nguyen ... [et al.] -- In vivo observations of rapid scattered light changes associated with neurophysiological activity / David M. Rector ... [et al.] -- Imaging the brain in action : real-time voltage-sensitive dye imaging of sensorimotor cortex of awake-behaving mice / Isabelle Ferezou, Ferenc Matyas, and Carl C.H. Petersen -- Flavoprotein fluorescence imaging of experience-dependent cortical plasticity in rodents / Katsuei Shibuki ... [et al.] -- Functional imaging with mitochondrial flavoprotein autofluorescence : theory, practice, and applications / T. Robert Husson and Naoum P. Issa -- Visualizing adult cortical plasticity using intrinsic signal optical imaging / Ron D. Frostig and Cynthia H. Chen-Bee -- Fourier approach for functional imaging / Valery A. Kalatsky -- Optical imaging of neuronal activity in the cerebellar cortex using neutral red / Timothy J. Ebner, Gang Chen, and Wangcai Gao -- Quantitative in vivo imaging of tissue absorption, scattering, and hemoglobin concentration in rat cortex using spatially modulated structured light / David J. Cuccia ... [et al.] -- Intraoperative optical imaging / K.C. Brennan and Arthur W. Toga -- Noninvasive imaging of cerebral activation with diffuse optical tomography / Theodore J. Huppert, Maria Angela Franceschini, and David A. Boas -- Fast optical signals : principles, methods, and experimental results / Gabriele Gratton and Monica Fabiani.
  • 2012 Springer
    Saudubray, J. M.; Van den Berghe, Georges; Walter, John.
    I. Diagnosis and Treatment: General Principles -- 1. Clinical Approach to Inborn Errors of Metabolism in Pediatrics / Jean-Marie Saudubray -- 2. Inborn Errors of Metabolism in Adults: A Diagnostic Approach to Neurological and Psychiatric Presentations / Frédéric Sedel -- 3. Newborn Screening for Inborn Errors of Metabolism / Bridget Wilcken, Piero Rinaldo, Dietrich Matern -- 4. Diagnostic Procedures: Functional Tests and Post-mortem Protocol / Guy Touati, Fanny Mochel, Daniel Rabier -- 5. Emergency Treatments / Carlo Dionisi-Vici, Hélène Ogier de Baulny -- II. Disorders of Carbohydrate Metabolism -- 6. The Glycogen Storage Diseases and Related Disorders / Pascal Laforêt, David A. Weinstein, G. Peter, A. Smit -- 7. Disorders of Galactose Metabolism / Gerard T. Berry, John H. Walter -- 8. Disorders of the Pentose Phosphate Pathway / Mirjam M.C. Wamelink, Vassili Valayannopoulos, Cornelis Jakobs -- 9. Disorders of Fructose Metabolism / Beat Steinmann, René Santer -- 10. Persistent Hyperinsulinaemic Hypoglycaemia / Pascale de Lonlay, Jean-Marie Saudubray -- 11. Disorders of Glucose Transport / René Santer, Jörg Klepper -- III. Disorders of Mitochondrial Energy Metabolism -- 12. Disorders of Pyruvate Metabolism and the Tricarboxylic Acid Cycle / Linda J. De Meirleir, Michèle Brivet, Angeles Garcia-Cazorla -- 13. Disorders of Mitochondrial Fatty Acid Oxidation and Related Metabolic Pathways / Andrew A.M. Morris, Ute Spiekerkoetter -- 14. Disorders of Ketogenesis and Ketolysis / Andrew A.M. Morris -- 15. Defects of the Respiratory Chain / Arnold Munnich, Agnès Rötig, Marlène Rio -- 16. Creatine Deficiency Syndromes / Sylvia Stöckler-Ipsiroglu, Saadet Mercimek- Mahmutoglu, Gajja S. Salomons -- IV. Disorders of Amino Acid Metabolism and Transport -- 17. Hyperphenylalaninaemia / John H. Walter, Robin H. Lachmann, Peter Burgard -- 18. 18 Disorders of Tyrosine Metabolism / Anupam Chakrapani, Paul Gissen, Patrick McKiernan -- 19. Branched-chain Organic Acidurias/Acidaemias / Hélène Ogier de Baulny, Carlo Dionisi-Vici, Udo Wendel -- 20. Disorders of the Urea Cycle and Related Enzymes / Frits A. Wijburg, Marie-Cécile Nassogne -- 21. Disorders of Sulfur Amino Acid Metabolism / Generoso Andria, Brian Fowler, Gianfranco Sebastio -- 22. Disorders of Ornithine Metabolism / Matthias R. Baumgartner, David Valle -- 23. Cerebral Organic Acid Disorders and Other Disorders of Lysine Catabolism / Georg F. Hoffmann, Stefan Kölker -- 24. Nonketotic Hyperglycinaemia (Glycine Encephalopathy) / Olivier Dulac, Marie-Odile Rolland --25. Disorders of Proline and Serine Metabolism / Jaak Jaeken -- 26. Transport Defects of Amino Acids at the Cell Membrane: Cystinuria, Lysinuric Protein Intolerance and Hartnup Disorder / Kirsti Näntö-Salonen, Harri Niinikoski, Olli G. Simell -- V. Vitamin-Responsive Disorders -- 27. Biotin-responsive Disorders / Matthias R. Baumgartner, Terttu Suormala -- 28. Disorders of Cobalamin and Folate Transport and Metabolism / David Watkins, David S. Rosenblatt, Brian Fowler -- VI. Neurotransmitter and Small Peptide Disorders -- 29. Disorders of Neurotransmission / Àngels García-Cazorla, K. Michael Gibson, Peter T. Clayton -- 30. Disorders in the Metabolism of Glutathione and Imidazole Dipeptides / Ertan Mayatepek, Jaak Jaeken -- 31. Trimethylaminuria and Dimethylglycine Dehydrogenase Deficiency / Valerie Walker, Ron A. Wevers -- VII. Disorders of Lipid and Bile Acid Metabolism -- 32. Dyslipidaemias / Annabelle Rodriguez-Oquendo, Peter O. Kwiterovich, Jr. -- 33. Disorders of Cholesterol Synthesis / Hans R. Waterham, Peter T. Clayton -- 34. Disorders of Bile Acid Synthesis / Peter T. Clayton -- 35. Disorders of Phospholipid and Glycosphingolipid Synthesis / Foudil Lamari, Fréderic Sédel, Jean-Marie Saudubray -- VIII. Disorders of Nucleic Acid and Heme Metabolism -- 36. Disorders of Purine and Pyrimidine Metabolism / Georges van den Berghe, M.-Françoise Vincent, Sandrine Marie -- 37. Disorders of Haem Biosynthesis / Charles Marquez Lourenço, Chul Lee, Karl E. Anderson -- IX. Disorders of Metal Transport -- 38. Disorders in the Transport of Copper, Iron, Magnesium, Manganese, Selenium and Zinc / Marc Bierings, Peter Clayton, Roderick H.J. Houwen -- X. Organelle-Related Disorders: Lysosomes, Peroxisomes, and Golgi and Pre-Golgi Systems -- 39. Disorders of Sphingolipid Metabolism and Neuronal Ceroid-Lipofuscinoses / Marie T. Vanier, Catherine Caillaud -- 40. Mucopolysaccharidoses and Oligosaccharidoses / J. Ed Wraith -- 41. Peroxisomal Disorders / Bwee Tien Poll-The, Patrick Aubourg, Ronald J.A. Wanders -- 42. Congenital Disorders of Glycosylation / Jaak Jaeken -- 43. Cystinosis / Michel Broyer, Patrick Niaudet -- Appendix A. Medications Used in the Treatment of Inborn Errors / JH Walter and JE Wraith.
  • 2006 Springer
    Fernandes, J.
    Diagnosis and treatment: general principles -- Disorders of carbohydrate metabolism -- Disorders of mitochondrial energy metabolism -- Disorders of amino acid metabolism and transport -- Vitamin-responsive disorders -- Neurotransmitter and small peptide disorders -- Disorders of lipid and bile acid metabolism -- Disorders of nucleic acid and heme metabolism -- Disorders of metal transport -- Organelle-related disorders: lysosomes, peroxisomes, and Golgi and pre-Golgi systems.
  • 1979-
    Altman, Philip L.; Katz, Dorothy Dittmer.
    PrintStatus: Not Checked OutLane Catalog Record
    v. 1. Mouse and rat -- v. 2. Hamster, guinea pig, rabbit, and chicken.
  • 2012
    Kumarasamy, Anicham Ponn; Lee, Hau Leung; Wein, Lawrence; Zenios, Stefanos A.
    This dissertation is composed of three essays that analyze incentive problems concerning the health care of end stage renal disease (ESRD) in the United States. The first essay is concerned with the unintended consequences of a proposed change to the system for allocating kidneys to patients on the transplant waiting list. In particular, policymakers in the United States have recently proposed to modify the kidney allocation system by assigning higher priority to patients who are on dialysis longer. The essay examines how this change may create an incentive for physicians to start their patients on dialysis prematurely and investigates how to mitigate this unintended behavior. The second essay investigates physician behavior directly from data, analyzing why the kidney function at which patients start dialysis has been rising over time in the United States. That is, why do patients seem to be starting dialysis earlier and earlier over time? The third essay is concerned with the quality of care of profit-maximizing dialysis providers. In particular, Medicare recently restructured its reimbursement system and publicly released previously confidential data on the quality of care of dialysis facilities. The essay analyzes how such policy changes influence the quality of care decisions of profit-maximizing dialysis providers. On the whole, this dissertation is intended to help policymakers as they make difficult decisions about kidney allocation policies, ESRD-related spending, dialysis reimbursement, and disclosing dialysis facility performance information.
  • 2010
    Samanez Larkin, Gregory R.; Carstensen, Laura L.; Knutson, Brian; McClure, Samuel M.; Wagner, Anthony D.
    As the proportion of older adults continues to grow rapidly here in the U.S. and across the globe, aging adults may be required to make increasingly more independent health-related and financial decisions. Thus, it is increasingly imperative to better understand the impact of age-related psychological changes on decision making. Although a growing body of research has linked age-related deficits in attention, memory, and cognitive control to changes in medial temporal and lateral prefrontal cortical function, remarkably little research has investigated the influence of aging on valuation and associated mesolimbic function in the striatum and medial prefrontal cortex. Likewise, theoretical accounts link age-related declines in a number of basic cognitive abilities to dopamine function, but research has largely neglected age differences in value-based learning and decision making which also rely on the dopamine system. Recent findings reveal age-related declines in the structure of striatal and medial frontal circuits, however it was not previously clear whether these structural declines contribute to functional deficits in incentive processing. Thus, the seven experiments presented here explored potential age differences across a range of value-based tasks from basic anticipatory and consummatory responses to reward cues (Experiments 1--2) to probabilistic value-based learning (Experiments 2--5) to investment decision making (Experiments 6--7). The studies focus on both age-related and non-age-related individual differences in learning and decision making across the adult life span. Overall, three sets of key findings emerge. The first set of experiments on anticipatory affect reveal evidence for an age-related asymmetry in the anticipation of monetary gains and losses, such that older adults appear less sensitive to the prospect of financial loss than younger adults. In a subset of adults, this anticipatory affective bias contributes to loss avoidance learning impairments through the sensitivity of the anterior insula. Thus, although a relative lack of anxiety about potential loss may contribute to increased well-being, this asymmetry may put individuals with blunted loss anticipation at risk for certain types of financial mistakes. In fact, we show that individuals who perform poorly on the laboratory-based loss avoidance learning task accrue more financial debt in the real world. The second set of experiments focus on age differences in value-based learning and reveal that although older adults show intact neural representation of the actual value of reward outcomes, there is an age-related decline in the neural representation of prediction error at outcome in the striatum and medial prefrontal cortex. Age differences in learning are magnified when choice set size is increased, but when the number of trials is extended older adults reach the same performance criterion as younger adults. The third set of experiments focus on age differences in risky financial decision making and reveal that older adults make more suboptimal choices than younger adults when choosing risky assets. Neuroimaging analyses reveal that the representation of expected value in the nucleus accumbens and medial prefrontal cortex is correlated with optimal investment decisions, and that the age-related increase in risky investment mistakes is mediated by a novel neural measure of variability in nucleus accumbens activity. The presentation of value information through visual decision aids improves investment choices in both younger and older adults. These findings are consistent with the notion that mesolimbic circuits play a critical role in optimal choice, and imply that providing simplified information about expected value may improve financial risk taking across the adult life span. Across the experiments, the findings suggest that both age-related affective biases and probabilistic learning impairments can influence decision making both in the laboratory and in the real world through insular and mesolimbic brain regions. Importantly, age-related impairments are reduced under supportive task conditions (designed to target the brain systems identified using neuroimaging). Together, the set of experiments presented here suggests that understanding how the brain processes value information may eventually inform the design of more targeted and effective behavioral interventions for investors of all ages.
  • 2008 ebrary
    Kasper, Hirschel; Sloan, Frank A.
    To find an answer, one must know the question : health economics and public policy / Henry J. Aaron -- Health capital : theory and empirical evidence / Donna Gilleskie -- What we know and don't know about the effects of cost sharing on the demand for medical care - and so what? / Joseph P. newhouse and Anna D. Sinaiko -- Adverse selection and moral hazard : implications for health insurance markets / Mark V. Pauly -- Direct-to-consumer advertising in health care : an overview of economic issues / Ernst R. Berndt and Julie M. Donohue -- Reefer Madness, Frank the Tank, or Pretty Woman : to what extent do addictive behaviors respond to incentives? / John Cawley -- Medical career choices and rates of return / Sean Nicholson -- The effects of incentives on pharmaceutical innovation / Frank A. Sloan and Chee-Ruey Hsieh -- Physician fees and behavior : implications for structuring a fee schedule / Thomas G. McGuire -- Physician pay for performance : alternative perspectives / Brian R. Golden and Frank A. Sloan -- Competition, information provision, and hospital quality / Gautam Gowrisankaran -- Summing up / Frank A. Sloan and Hirschel Kasper.
  • 2006 CRCnetBASE
    Hyatt, Nigel.
  • 2008 Springer
    Bartone, Giovanni; Crovella, Feliciano; Fei, Landino.
  • 2006 Springer
    Shively, Jessup M.
  • 2010
    Glazer, Dariya Sergiuivna; Altman, Russ B.; Cherry, Joe H.; Levitt, Michael; Sherlock, Gavin.
    Structural Genomics consortia aim to determine the structure of proteins with novel folds. In order to interpret their biological significance, it is critical to annotate the functions of these structures. Most structures are solved by X-ray crystallography experiments and represent static snapshots of the molecules. Structure-based function prediction methods do not perform well when the snapshots fail to display the relevant functional conformations. We show that coupling structure-based function prediction methods to molecular dynamics simulations considerably improves their performance in locating calcium binding sites. Our approach can be easily extended to other functions of interest. In particular, we generated short- to medium- scale molecular simulation trajectories (1ns -- 10ns) using GROMACS, a software suite developed for creating molecular dynamics simulations. Gromos 43a5, Gromos 53a6, AMBER '96, AMBER '99SB, AMBER '03, and OPLS-AA force fields were used to generate trajectories for 11 pairs of PDB structures, HOLO and APO form for the presence of calcium ions in the structures (22 structrures in total). Extracting structures at various time points over the course of the simulations we created structural ensembles which inform about the dynamic nature of each of the simulation systems. Using FEATURE, a machine learning algorithm that evaluates the presence of enriched physico-chemical properties around a site of interest, we analyzed the structural ensembles for the presence of calcium binding sites. We devised a clustering algorithm which allowed for definitive determination of the similarity of the local environments around the points identified by FEATURE as potential calcium binding site centers in different structural ensembles for each of the 22 PDB structures. Our results indicate that short scale simulations with 2 or 3 different force fields generate sufficient structural diversity to allow for improved identification of calcium binding sites. Furthermore, inclusion of calcium ions in the simulation systems does not significantly improve the performance of FEATURE. This result highlights the need for improved force fields, such that the dynamic nature of calcium binding sites can be accurately reproduced.
  • 2010 WHO
    "Half the world's people currently live in rural and remote areas. The problem is that most health workers live and work in cities. This imbalance is common to almost all countries and poses a major challenge to the nationwide provision of health services. Its impact, however, is most severe in low income countries. ... The World Health Organization (WHO) has therefore drawn up a comprehensive set of strategies to help countries encourage health workers to live and work in remote and rural areas. These include refining the ways students are selected and educated, as well as creating better working and living conditions. ... The guidelines ... complement the WHO Global Code of Practice on the International Recruitment of Health Personnel, adopted by the Sixty-third World Health Assembly in May 2010. The Code offers a framework to manage international migration over the medium to longer term. The guidelines are a tool that can be used straight away to address one of the first triggers to internal and international migration - dissatisfaction with living and working conditions in rural areas. Together, the code of practice and these new guidelines provide countries with instruments to improve workforce distribution and enhance health services." - p. i
    Also available: Print – 2010
  • 2014 Springer
    Trifilieff, Alexandre.
    Chronic obstructive pulmonary disease (COPD) is a multi-component condition that results in increasingly limited airflow, usually associated with an abnormal inflammatory response of the lung. It constitutes a major public health burden worldwide, while only very few effective therapies are available. This book provides a comprehensive overview of the development of Onbrez Breezhaler, a newly approved once-daily inhaled 2 agonist for the treatment of COPD. It reviews the current pharmacotherapy for COPD and discusses topics such as the chemical design and the pre-clinical pharmacology of the molecule, the early clinical development, the INHANCE study (which provides a successful example of the use of an adaptive design in the confirmatory setting) and the Phase III clinical efficacy study, as well as the history and performance of the Breezhaler device. Finally, a list of emerging targets is included that could well offer future treatment options for COPD.
  • v. 1-2, 1933-34.
    PrintStatus: Not Checked OutLane Catalog Record
  • Truven, Search Index nominum via the main Micromedex search screen.
    Also available: Print – <2011>
  • v. 1-2, 4, 1960-69.
    Welt, Isaac D.
    PrintStatus: Not Checked OutLane Catalog Record
    v. 1 (1931-1950) -- v. 2., pt. 1-2. (1951-1955) -- v. 3. (1956-1959).
  • 2007 Springer
    Khare, C. P.
  • 2007 CRCnetBASE
    Aswathanarayana, U.; Murty, T. S.; Nirupama, N.
    Prologue / Barbara H. Keating -- Pt. 1. Geostructural environment of tsunami genesis -- A historical account of the earthquakes and tsunamis in the Indian Ocean / B. K. Rastogi -- Impact of coastal morphology, structure and seismicity on the tsunami surge / K.S.R. Murthy ... [et al.] -- Tsunamigenic sources in the Indian Ocean: factors and impact on the Indian landmass / R.K. Chadha -- Paleo-tsunami and storm surge deposits / K. Arun Kumar, H. Achyuthan, and N. Shankar -- Overview and integration of part 1 / U. Aswathanarayana -- Pt. 2. Modelling of tsunami generation and propagation -- A review of classical concepts on phase and amplitude dispersion: application to tsunamis / N. Nirupama ... [et al.] -- A partial explanation for the initial withdrawal of the ocean during a tsunami / N. Nirupama ... [et al.] -- The energetics of the tsunami of 26 December 2004 in the Indian Ocean: a brief review / N. Nirupama ... [et al.] -- Possible amplification of the tsunami through coupling with internal waves / N. Nirupama ... [et al.] -- Numerical modeling of the Indian Ocean tsunami / Z. Kowalik ... [et al.] -- Modelling techniques for understanding the Indian Ocean tsunami propagation / V. P. Dimri and K. Srivastava -- Validation of tsunami beach run-up height predictive model based on work-energy theorem / G. Muraleedharan ... [et al.] -- Normal modes and tsunami coastal effects / N. Nirupama ... [et al.] -- Helmholtz mode and K-S-P waves: application to tsunamis / N. Nirupama ... [et al.] -- Numerical models for the Indian Ocean tsunami of 26 December 2004: a brief review / P. Chittibabu and T.S. Murty -- The Cauchy-Poisson problem: application to tsunami generation and propagation / N. Nirupama ... [et al.] -- A review and listings of tsunami heights and travel times for the 26 December 2004 event / I. Nistor ... [et al.] -- Overview and integration of part 2 / N. Nirupama -- Pt. 3. Tsunami detection and monitoring systems -- Satellite detection of pre-earthquakes thermal anomaly and sea water turbidity associated with the great Sumatra earthquake / A. K. Saraf ... [et al.] -- Possible detection in the ionosphere of the signals from earthquake and tsunamis / T. S. Murty ... [et al.] -- Seismo-electromagnetic precursors registered by DEMETER satellite / A.K. Gwal ... [et al.] -- Web-enabled and real-time reporting: cellular based instrumentation for coastal sea level and surge monitoring / A. Joseph and R. G. Prabhudesai -- Methodologies for tsunami detection / T.S. Murty ... [et al.] -- Tsunami travel time atlas for the Indian Ocean / P.K. Bhaskaran ... [et al.] -- Overview and integration of part 3 / N. Nirupama -- Pt. 4. Biophysical and socio-economic dimensions of tsunami damage -- Performance of structures affected by the 2004 Sumatra tsunami in Thailand and Indonesia / M. Saatcioglu, A. Ghobarah, and I. Nistor -- Field observations on the tsunami impact along the Kerala Coast, Southwest India / N.P. Kurian, T.N. Prakash, and M. Baba -- Ecological impact on the Indian Ocean tsunami / C.S.P. Iyer -- Tsunami damage to the south eastern coast of India / N. Chandrasekar and R. Ramesh -- Hydrophysical manifestations on the Indian Ocean tsunami / Y. Sadhuram, T.V. Ramana Murthy, and B.P. Rao -- Tsunamis and marine life / D.V. Subba Rao ... [et al.] -- Tsunami impact on coastal habitats of India / P.N. Sridhar ... [et al.] -- Overview and integration of part 4 / U. Aswathanarayana -- Pt. 5. Quo Vadis -- Protection measures against tsunami-type hazards for the coast of Tamil Nadu, India / V. Sundar -- Protective role of coastal ecosystems in the context of the tsunami in Tamil Nadu Coast, India: implications for hazard preparedness / A. Mascarenhas and S. Jayakumar -- Integrated preparedness systems / U. Aswathanarayana -- Social and political aspects of tsunami response, recovery, and preparedness planning: a transdisciplinary approach from Canada / C. Amaratunga and H. Smith Fowler -- An ideal conceptual tsunami warning system for the Indian Ocean / T.S. Murty ... [et al.] -- Overview and integration of part 5 / N. Nirupama.
  • v. 1, 1953.
    Mukerji, Bishnupada.
    PrintStatus: Not Checked OutLane Catalog Record
    1. Indigenous drugs.
  • 2011 Springer
    Bavry, Anthony A.; Kumbhani, Dharam J.
    1 Vascular anatomy -- 2 Catheters, guidewires, sheaths, and balloons -- 3 Complex coronary interventions -- 4 Fractional flow reserve and intravascular ultrasound -- 5 Peripheral interventions -- 6 Structural heart disease.
  • 2006 Springer
    Ben-Aryeh, Asher; Goerge, Robert M.
  • Google Books
    Dutton, Thomas.
    Also available: Print – 1892.
  • 2013 ScienceDirect
    Hallam, Richard S.
    Individual Case Formulation presents formulation as a process that can be taught systematically to trainee therapists. The book begins by discussing assorted theories of case formulation, and critiques their ability to be applied in real world situations. The individual case formulation approach is then defined and discussed as a way to integrate the best of what different theoretical orientations have to offer in conjunction with the expertise and clinical judgment of the therapist. The book proposes a systemic/functional framework that focuses on difficulties as defined by the client and emphasizes constructive solutions to problems rather than symptom reduction. Moving from theory to application, the book then guides therapists in how to conduct assessment interviews, how to reach a provisional formulation, how to test that formulation for accuracy and reformulate if necessary, how a therapist can make explicit what their clinical reasoning was in making the case formulation, and provides case examples and transcripts so readers will better grasp the concepts in action.
  • 2011
    Drabant, Emily Marguerite.
    PrintStatus: Not Checked OutLane Catalog Record
  • 2015 Springer
    Fischer, Tobias; Langanke, Martin; Marschall, Paul; Michl, Susanne.
    In 2009 the University Medicine Greifswald launched the "Greifswald Approach to Individualized Medicine" (GANI_MED) to implement biomarker-based individualized diagnostic and therapeutic strategies in clinical settings. Individualized Medicine (IM) has led not only to controversies about its potentials, but also about its societal, ethical and health economic implications. This anthology focusses on these areas and includes ? next to clinical examples illustrating how the integrated analysis of biomarkers leads to significant improvement of therapeutic outcomes for a subgroup of patients ? chapters about the definition, history and epistemology of IM. Additionally there is a focus on conceptual philosophical questions as well as challenges for applied research ethics (informed consent process, the IT-based consent management and the handling of incidental findings). Finally it pays attention to health economic aspects. The possibilities of IM to initiate a paradigm shift in the German health care provision are investigated. Furthermore, it is asked whether the G-DRG system is ready for the implementation of such approaches into clinical routine.
  • 2002 CRCnetBASE
    Hess-Kosa, Kathleen.
  • 2003 CRCnetBASE
    Heinsohn, Robert Jennings; Cimbala, John M.; Heinsohn, Robert Jennings.
  • 2001 CRCnetBASE
    Godish, Thad.
  • 2012 Springer
    Yildirim, Sibel.
  • 2012 Springer
    Heine, Vivi M.
  • 2011 Springer
    Aigner, K.; Stephens, Frederick O.
  • v. 1-2, 1948-49.
    Patty, F. A.; Brozek, Josef M.
    PrintStatus: Not Checked OutLane Catalog Record
  • v. 1-2, 1958-63.
    Patty, F. A.; Clayton, George D.
    PrintStatus: Not Checked OutLane Catalog Record
    v. 1. General principles -- v. 2. Toxicology.
  • 2002 Wiley
    Klefenz, Heinrich.
    ch. 1. Introduction to Functional Biotechnology, p. 1-72 -- ch. 2. Organizational Structures, p. 73-76 -- ch. 3. Markets and Factors, p. 77-78 -- ch. 4. Biotechnology and Medicine, p. 79-116 -- ch. 5. Drug Discovery, p. 117-144 -- ch. 6. Molecular Pharma-Biotechnology, p. 145-194 -- ch. 7. Research and Development, p. 195-200 -- ch. 8. Pharmaceutical Production, p. 201-238 -- ch. 9. Safety, p. 239-240 -- ch. 10. Environment, p. 241-243 -- ch. 11. Ethics, p. 245-246 -- ch. 12. Companies, Institutes, Networks, and Organizations, p. 247-261.
  • 2003 ScienceDirect
    Aalbersberg, W. Y.
  • 2005 CRCnetBASE
    Handen, Jeffrey S.
  • 2008 CRCnetBASE
    Reichert, William M.
    Overview of wound healing in different tissue types / John D. Stroncek and William M. Reichert -- Considerations for chronically implanted electrodes for brain interfacing / Warren M. Grill -- Thermal considerations for the design of an implanted cortical brain-machine-interface / Patrick D. Wolf -- In vitro models for neuroelectrodes: a paradigm for studying tissue-materials interactions in the brain / Vadim Polikov ... [et al.] -- In vivo solute diffusivity in brain tissue surrounding indwelling neural implants -- Michael J. Bridge and Patrick A. Tresco -- A molecular perspective on understanding and modulating the performance of chronic CNS recording electrodes / Wei He and Ravi V. Bellamkonda -- Soft, fuzzy, and bioactive conducting polymers for improving the chronic performance of neural prosthetic devices / Dong-Hwan Kim ... [et al.] -- Strategies for regeneration and repair in the injured CNS / Molly S. Shoichet ... [et al.].
  • 2008 Springer
    Baudisch, Annette.
  • 2013
    Abel, Emily K.
    PrintStatus: Not Checked OutLane Catalog Record
    The good death at home -- Medical professionals (sometimes) steps in -- Cultivating detachment, sidetracking care -- Institutionalizing the incurable -- "All our dread and apprehension" -- "Nothing more to do" -- A place to die -- The sacred and the spiritual.
  • 2011 Springer
    Liamputtong, Pranee.
    Infant feeding beliefs and practices across cultures: an introduction -- Managing the lactating body: the breastfeeding project in the age of anxiety -- Attitudes to breastfeeding -- The imperative to breastfeed: an Australian perspective -- Infant feeding and the problems of policy -- Shifting identities: social and cultural factors that shape decision-making around sustaining breastfeeding -- Breastfeeding under the blanket: exploring the tensions between health and social attitudes to breastfeeding in the United States, Ireland, and the United Kingdom -- Breastfeeding beliefs and practices among employed women: a Thai cultural perspective -- Good mothers and infant feeding practices among women in Northern Thailand -- Breastfeeding in sub-Saharan Africa: still the best despite the risk of HIV -- Infant feeding in the era of HIV: challenges and opportunities -- Facing competing cultures of breastfeeding: the experience of HIV-positive women in Burkina Faso -- Fluid boundaries: multiple meanings of the illness 'moto' in Northern Malawi -- From traditional to optimal breastfeeding practices: selected cases from Central and Southern Africa -- Hoki kit e ukaipo: reinstating Maori infant care practices to increase breastfeeding rates -- Infant feeding in indigenous Australian communities -- Breastfeeding, vertical disease transmission and the volition of medicines in Malawi -- Infant feeding beliefs and practices in Islamic societies: focusing on rural Turkey -- Early initiation of breastfeeding and its beneficial effects in Japan -- Socio-cultural factors influencing feeding patterns within 6 months postpartum in rural Vietnam -- Infant feeding following migration: attitudes and practices of women born in Turkey and Vietnam after migration to Australia.
  • Pastore, Lisa M.; MacDorman, Marian F.
    Also available: Print – 1995
  • 2009 Springer
    Kienapfel, Heino; Kühn, K.-D.
  • 2012 Springer
    Trebše, Rihard.
    Part 1 -- Introduction / Rihard Trebše -- Joint Replacement: Historical Overview / Rihard Trebše, Anže Mihelič -- Biomaterials in Artificial Joint Replacements / Rihard Trebše -- The Definition of Prosthetic Joint Infections (PJI) / Rihard Trebše, Andrej Trampuž -- Classification of Prosthetic Joint Infections / Rihard Trebše, Anže Mihelič -- The Epidemiology of Total Joint Arthroplasty Infections / David J. Jaekel, Kevin L. Ong, Edmund C. Lau -- Septic Complications in Arthroplasty / Gerold Labek -- Perioperative Antibiotic Prophylaxis in Total Joint Arthroplasty / Nataša Faganeli -- Risk Factors for Prosthetic Joint Infections / René Mihalič, Matevž Topolovec -- Pathogenesis of Prosthetic Joint Infections / Rihard Trebše, Jurij Štalc -- Bacteria-Biomaterial Interactions / Antti Soininen, Emilia Kaivosoja, Jaime Esteban -- Biomaterial-Host Interactions in Aseptic and Septic Conditions / Jukka Pajarinen, Yuya Takakubo, Zygmunt Mackiewicz -- Influence of Wear Particles on Local and Systemic Immune System / Emmanuel Gibon, Stuart B. Goodman -- Diagnostic Evaluations / Rihard Trebše -- Synovial Fluid Cytology / René Mihalič, Dunja Terčič -- Histological Analysis of Periprosthetic Tissue for Detecting Prosthetic Joint Infection / Andrej Cör -- Microbiological Diagnosis of Prosthetic Joint Infection / Jaime Esteban, Concepción Pérez-Jorge, Ramón Pérez-Tanoira -- Microbiological Processing of Samples in the Investigation of Suspected Prosthetic Joint Infection / David G. Partridge, Rob Towsend -- Part 2 -- Molecular Diagnosis of Prosthetic Joint Infection / Jaime Esteban, Diana Molina-Manso, Gema del-Prado -- Current Treatment Strategies in Prosthetic Joint Infections / Rihard Trebše Total Ankle Replacement Infections / Michaela Maria Schneiderbauer -- Periprosthetic Infection Issues with Osseointegrated (OI) Implant Technology in Amputees / Catherine Loc-Carrillo, Alec C. Runyon, James Peter Beck -- The Algorithm for Diagnostic Evaluation and Treatment / Rihard Trebše, Andrej Trampuž -- Bone Grafts and Bone Graft Substitutes in Infected Arthroplasty / Martin Clauss, Thomas Ilchmann.
  • 2006
    Bannister, Barbara A.; Gillespie, Stephen H.; Jones, Jane.
    PrintStatus: Not Checked OutLane Catalog Record
    The nature and pathogenesis of infection -- Structure and classification of pathogens -- Laboratory techniques in the diagnosis of infection -- Antimicrobial chemotherapy -- Infections with skin, mucosal and soft-tissue disorders -- Upper respiratory tract infections -- Lower respiratory tract infections -- Gastrointestinal infections and food poisoning -- Infections of the liver -- Infections of the urinary tract -- Childhood infections -- Infections of the cardiovascular system -- Infections of the central nervous system -- Bone and joint infections -- Genital and sexually transmitted diseases -- HIV infection and retroviral diseases -- Congenital and perinatal infections -- Tuberculosis and other mycobacterial diseases -- Bacteraemia and sepsis -- Pyrexia of unknown origin -- Post-infectious disorders -- Infections in immunocompromised patients -- Hospital infections -- Travel-associated and exotic infections -- Control of infection in the community -- Emerging and re-emerging infections.
  • 2008
    Playfair, J. H. L.; Bancroft, Gregory J.
    PrintStatus: Not Checked OutLane Catalog Record
  • 2006 Karger
    Dittmar, Thomas; Schmidt, Axel; Zaenker, Kurt S.
    In remembrance of Rudolf Virchow (1821-1902) / Schmidt, A. -- In memoriam of Rudolf Virchow: a historical retrospective including aspects of inflammation, infection and neoplasia / Schmidt, A., Weber, O.F. -- Aneuploidy and cancer: from correlation to causation / Duesberg, P. ... [et al.] -- Adult stem cell theory of the multi-stage, multi-mechanism theory of carcinogenesis: role of inflammation on the promotion of initiated stem cells / Trosko, J.E., Tai, M.-H. -- Helicobacter pylori and gastric neoplasia / Leung, W.K. -- Schistosomiasis and neoplasia / Yosry, A. -- Relevant oncogenic viruses in veterinary medicine: original pathogens and animal models for human disease / Truyen, U., L"chelt, M. -- The inflammatory tumor microenvironment and its impact on cancer development / de Visser, K.E., Coussens, L.M. -- Co-opting macrophage traits in cancer progression: a consequence of tumor cell fusion? / Pawelek, J. ... [et al.] -- Carcinogenesis driven by bone marrow-derived stem cells / Dittmar, T. ... [et al.] -- Chemokine-directed metastasis / Gomperts, B.N., Strieter, R.M. -- Involvement of chemokine receptors in organ-specific metastasis / Zlotnik, A. -- Visualization of tumor cell extravasation / Heyder, C. ... [et al.] -- Options for visualizing metastatic disease in the living body / Helms, M.W., Brandt, B.H., Contag, C. -- Infection, inflammation and neoplasia: an interdisciplinary challenge / Zaenker, K.S.
    Also available: Print – 2006
  • 2007 Springer
    Meani, E.
  • 2012 Springer
    Van Saene, H. K. F.
    pt. I. Essentials in clinical microbiology -- pt. II. Antimicrobials -- pt. III. Infection control -- pt. IV. Infections on ICU -- pt. V. Special topics.
  • 2012 Springer
    Stein-Streilein, Joan.
    The Eye as a model for immune privilege -- Immune privilege of the testis: meaning, mechanisms, and manifestations -- The Role of intrauterine immune privilege in perinatal infectious diseases -- The Liver as an immune-privileged site -- Immune homeostasis of the lung: the role of regulatory NKT cells in asthma -- Immune homeostasis of the gut.
  • 2015 Springer
    Maschmeyer, Georg; Rolston, Kenneth V. I.
  • 2006
    Petersen, Eiko E.
    PrintStatus: Not Checked OutLane Catalog Record
    Pathogens -- Defense systems -- Detection of pathogens -- Anti-infectives (antibacterials, virostatics, antimycotics, antiparasitics, antiseptics, immunoglobulins) -- Signs of Infection -- Diagnosis of infections during gynecological examination -- Gynecologic infections -- Infections during pregnancy -- Peripartal and puerperal infections -- Inflammation of the breast -- Sexually transmitted infections -- Helminthic infections -- Infections of other body regions -- Self-inflicted infections -- Prevention of infections.
  • 2013 Springer
    Humphreys, Hilary; Paul, Mical; Winter, Bob.
    Infections in critically ill patients are more common than in most other parts of the hospital, and are often the most complicated to manage. Underlying disease and the reasons for admission make the diagnosis, management and prevention of infection challenging. Developments in technology, the treatment of previously untreatable malignancies, complex surgery procedures, and an increasing age profile result in more patients vulnerable to infection and a greater number of patients needing critical care support. Infections in the Adult Intensive Care Unit is designed to help trainee and practicising physician, surgeon or other medical professional manage the acutely ill patient in the critical care unit, before transfer from the emergency department, or on the hospital ward where effective management may avoid admission to the critical care unit. It has been co-authored by a clinical microbiologist, intensivist and clinical infectious diseases physician to cover some of the major infections presenting in the adult critical care unit. It provides broad principles to be used based on the latest evidence combined with common sense and the results of many years of combined experience.
  • 2009 Am Soc Microbiol
    Schlossberg, David.
    Contributors -- Preface -- Preface to the first edition -- 1: At the shore / Mark A Clemence and Richard L Guerrant -- 2: Freshwater: from lakes to hot tubs / Bertha S Ayi and David Dworzack -- 3: Camper's uninvited guests / Gordon E Schutze and Richard F Jacobs -- 4: Infections in the garden / Burke A Cunha and Diane H Johnson -- 5: With man's best friend / Julie M Collins and Bennett Lorber -- 6: Around cats / Ellie J C Goldstein and Craig E Greene -- 7: Feathered friends / Matthew E Levison -- 8: Less common house pets / Bruno B Chomel -- 9: With man's worst friend : the rat / James G Fox -- 10: Closed due to rabies / Jesse D Blanton and John W Krebs -- 11: Sports: the infectious hazards / Arezou Minooee, Leland S Rickman, and Geeta Gupta -- 12: Traveling abroad / Martin S Wolfe -- 13: From boudoir to bordello: sexually transmitted diseases and travel / Jonathan M Zenilman -- 14: Infections from body piercing and tattoos / Mukesh Patel and C Glenn Cobbs -- 15: Infectious diseases at high altitude / Buddha Basnyat, Thomas A Cumbo, and Robert Edelman -- 16: Infectious risks of air travel / Alexandra Mangili and Mark Gendreau -- 17: Perils of the petting zoo / John R Dunn and Frederick J Angulo -- 18: Infections on cruise ships / Vivek Kak -- 19: Exotic and trendy cuisine / Jeffrey K Griffiths -- Index.
  • 2014 Ovid
    Marra, Christina M.; Scheld, W. Michael; Whitley, Richard J.
    "This clinical reference on central nervous system infections is now in its thoroughly revised, updated Fourth edition. Over 70 leading experts provide comprehensive, current information on all infections--both neural-specific and systemic--that involve the central nervous system. Areas with significant new clinical information include treatment of tuberculosis, non-tubercular mycobacterial infections, brain abscess, and Lyme disease"--Provided by publisher.
  • 2013 Springer
    Kutikhin, Anton G.; Brusina, Elena B.; Yuzhalin, Arseniy E.
    The Criteria of Inclusion of Infectious Agents in the List of Biological Carcinogens -- General Mechanisms of Biological Carcinogenesis -- The Role of Bacteria in Cancer Development -- The Role of Protozoa in Cancer Development -- The Role of Helminthes and Fungi in Cancer Development -- Organ Microbiota in Cancer Development: The Holy Grail of Biological Carcinogenesis -- Conclusions: Are We There Yet?
  • 2014 Springer
    Stosor, Valentina; Zembower, Teresa R.
    While advances in both the treatment of cancer and the management of its complications have led to significant improvement in patient survival, infections remain a significant cause of morbidity and mortality in patients with neoplastic disease. In this patient population, infection risk results from a complex interplay between the host's underlying immunodeficiencies, local tumor effects, and treatment-induced immunosuppression. New chemotherapeutic approaches and antimicrobial prophylaxis and treatment practices continue to shape the spectrum of infections in these patients. Clinicians who treat infections in cancer patients are continually challenged by the emergence of new pathogens and by the increasing antimicrobial resistance of established ones. The aim of this book, is to emphasize unique aspects of management of infectious diseases in the cancer patient. With the increasing complexity of this patient population, optimal management requires a multidisciplinary approach, and this fact is fully reflected in the contributions, all from recognized authorities in the field. Ultimately, it is hoped that this volume will assist specialists in infectious diseases and haematology/oncology in the diagnosis, management, and prevention of infection and optimization of the overall care of patients with malignancies.
    Also available: Print – 2014
  • 2009 Springer
    Norman, Dean C.; Yoshikawa, Thomas T.
    Concepts and principles of infections and aging -- Epidemiology of aging and infectious diseases -- Factors predisposing to infection -- Clinical features of infection -- Role and importance of functional assessment in infections -- Principles of antimicrobial therapy -- Common infections -- Sepsis -- Bronchitis and pneumonia -- Tuberculosis in older adults -- Infective endocarditis -- Intra-abdominal infections -- Infectious diarrhea -- Urinary tract infection -- Bacterial meningitis and brain abscess -- Osteomyelitis and septic arthritis -- Skin and soft tissues infections -- Herpes zoster -- Orofacial and odontogenic infections in the elderly -- Ocular infections -- Otitis externa, otitis media, and sinusitis -- Prosthetic joint infections in elderly patients -- Staphylococcal and enterococcal infections -- Fungal infections -- Viral infections -- Unique infectious disease problems -- Infections in the long-term care setting -- Infection control programs in nursing homes -- Infections in diabetes -- Vaccinations -- Nutrition and infection -- Sexually transmitted diseases -- Human immunodeficiency virus/acquired immunodeficiency syndrome -- SARS and West Nile virus.
  • 2010 Springer
    Sintchenko, Vitali.
    Informatics for infectious disease research and control -- Bioinformatics of microbial sequences -- Mining databases for microbial gene sequences -- Comparative genomics of pathogens -- Systems microbiology: gaining insights in transcriptional networks -- Host-pathogen systems biology -- Text mining for discovery of host-pathogen interactions -- Network approach to understanding pathogen population structure -- Computational epitope mapping -- Pangenomic reverse vaccinology -- Immunoinformatics: the next step in vaccine design -- Understanding the shared bacterial genome -- Computational grammars for interrogation of genomes -- In silico discovery of chemotherapeutic agents -- Informatics for healthcare epidemiology -- Automated, high-throughput surveillance systems for public health -- Microbial genotyping systems for infection control -- Temporal and spatial clustering of bacterial genotypes -- Infectious disease ontology -- Populations, patients, germs and genes: ethics of genomics and informatics in communicable disease control.
  • 2013 Wiley
    M'ikanatha, Nkuchia M.
    This fully updated edition of Infectious Disease Surveillance is for frontline public health practitioners, epidemiologists, and clinical microbiologists who are engaged in communicable disease control. It is also a foundational text for trainees in public health, applied epidemiology, postgraduate medicine and nursing programs. The second edition portrays both the conceptual framework and practical aspects of infectious disease surveillance. It is a comprehensive resource designed to improve the tracking of infectious diseases and to serve as a starting point in the developme.
  • 2013 Springer
    Grimes, D. Jay; Kanki, Phyllis J.
    Infectious Diseases: Selected Entries from the Encyclopedia of Sustainability Science and Technology presents authoritative, peer-reviewed contributions from leading experts on a wide range of major infectious diseases of global importance. Infectious diseases account for more than 17 million deaths each year worldwide. While modern medicine and technology have diminished the threat of many of these pathogens in high-income countries, the ever present threats of re-emerging infections, population mobility, natural disasters, and pathogen genetic variability are but some of the reasons for the dynamic threat of this broad category of risks to human health. An indispensable resource for students and scientists, the volume also covers some of the new technologies currently under development for infectious disease prevention, treatment, and eradication. The greater part of the infectious disease burden remains in the tropics, where low and middle-income countries lack the resources, infrastructure, and health systems to mount or sustain control efforts. Many contributions describe the efforts of the scientific research community and international donor agencies to achieve the integrated goals of vigilant surveillance, improved and cost-effective diagnostics, and treatment for sustainable disease control.Describes the dynamic nature of infectious disease agents and their complex interactions with the environment and their human and animal hosts Covers new technologies for antibiotics, vaccines, and treatment Features several contributions on waterborne infectious diseases, including enteric viruses and bacterial pathogens in the ocean Provides an excellent introduction for those entering the field, as well as new insights for advanced researchers and industry experts
  • 2014 Springer
    v. 2 Springer
    Adhikari, Rameshwar; Thapa, Santosh.
    The volumes address the interdisciplinary scientific approach for the systemic understanding of connections between major human diseases and their treatment regime by applying the tools and techniques of nanotechnology. It also highlights the interdisciplinary collaborative researches for innovation in Biomedical Sciences.
    Also available: Print – v. 1-2, 2014.
  • 2007 CRCnetBASE
    Jacobson, Elliott R.
  • 2005 Springer
    Bendinelli, Mauro; Friedman, Herman; Klein, Thomas W.
  • 2005 Springer
    Calisher, Charles H.; Peters, C. J.
  • 2007 Springer
    Rello, Jordi.
    Approach to the febrile patient in the intensive care unit -- Cardiovascular monitoring in severe sepsis or septic shock -- Cardiopulmonary resuscitation and infection -- Opportunistic infections in the intensive care unit: a microbiologic overview -- Infections in critically ill solid organ transplant patients -- HIV in the intensive care unit -- Fungal infections -- Using protocols to improve the outcomes of critically ill patients with infection: focus on ventilator-associated pneumonia and severe sepsis -- Microbial surveillance in the intensive care unit -- Antimicrobial prophylaxis in the intensive care unit -- Antifungal therapy in the intensive care unit -- Dose adjustment and pharmacokinetics of antibiotics in severe sepsis and septic shock -- Prescription of antimicrobial agents in patients undergoing continuous renal replacement therapy -- Methods for implementing antibiotic control in the intensive care unit -- Use of antibiotics in pregnant patients in the intensive care unit -- Immunomodulation in sepsis -- Antibiotic induced diarrhea -- Fundamentals of infection control and strategies for the intensive care unit -- Antibiotic resistance in the intensive care unit -- Epidemiology of pseudomonas aeruginosa in the intensive care unit -- How to control MRSA spread in the intensive care unit -- Epidemiology of acinetobacter baumannii in the intensive care unit -- Brain abscess -- Falciparum malaria -- Toxic shock syndromes -- Acute infective endocarditis -- Influenza -- Bloodstream infection in the intensive care unit -- Bloodstream infections in patients with total parenteral nutrition catheters -- Hemodialysis catheter-related infections -- Infection of pulmonary arterial and peripheral arterial catheters -- Prevention of catheter-related bloodstream infections in critical care patients -- Meningococcemia -- Septic shock -- Tracheobronchitis in the intensive care unit -- Sever community-acquired pneumonia -- Legionnaires' disease -- Adjunctive and supportive measures for community-acquired pneumonia -- Respiratory infection in immunocompromised neutropenic patients -- Pneumonia in non-neutropenic immunocompromised patients -- Community-acquired respiratory complications in the intensive care unit: pneumonia and acute exacerbations of COPD -- Management of hospital-associated pneumonia in the intensive care unit -- Assessment of resolution of ventilator associated pneumonia -- Invasive devices in the pathogenesis of nosocomial pneumonia -- Multiple organ dysfunction syndrome -- Sepsis in obstetrics -- Diagnosis and management of intra-abdominal sepsis -- Surgical site infection control in the critical care environment -- Severe soft tissue infections: a syndrome-based approach -- Vascular graft infections -- Acute mediastinitis -- Pancreatic infection -- Urinary tract infections -- Neurosurgical infections in intensive care unit patients -- Biliary tract infections.
  • 2010
    "THE INFECTIOUS DISEASES OF HAITI is one in a series of GIDEON e-books which summarize the status of individual infectious diseases, in every country of the world. Data are based on the GIDEON database (www.gideononline.com) which relies on standard text books, peer-review journals, Health Ministry reports and ProMED, supplemented by an ongoing search of the medical literature. Chapters are arranged alphabetically, by disease name. Each section is divided into four sections: 1. Descriptive epidemiology; 2. Summary of clinical features; 3. Status of the disease in Haiti ; 4. References. The initial items in the first section, Descriptive epidemiology, are defined as follows: Agent: Classification (e.g., virus, parasite) and taxonomic designation; Reservoir: Any animal, arthropod, plant, soil or substance in which an infectious agent normally lives and multiplies, on which it depends primarily for survival, and where it reproduces itself in such a manner that it can be transmitted to a susceptible host; Vector: An arthropod or other living carrier which transports an infectious agent from an infected organism or reservoir to a susceptible individual or immediate surroundings; Vehicle: The mode of transmission for an infectious agent. This generally implies a passive and inanimate (i.e., non-vector) mode. There are 347 generic infectious diseases in the world today. 198 of these are endemic, or potentially endemic, to Haiti. A number of other diseases are not relevant to Haiti and have not been included in this book. In addition to endemic diseases, we have included all published data regarding imported diseases and infection among expatriates from this country. The availability and quality of literature regarding specific infectious diseases varies from country to country. As such, you may find that many of the sections in this book are limited to a general discussion of the disease itself - with no data regarding the country under review. Since this book focuses on Geographic Medicine, it does not include detailed information on diagnostic testing, pathogenesis, therapy or molecular biology. Many of the diseases are generic. For example, such designations as Pneumonia bacterial and Urinary tract infection include a number of individual diseases. These appear under the subheading, Synonyms, listed under each disease. The entire book will be updated on a regular basis.
  • 2006
    Baker, Carol J.; Klein, Jerome O.; Remington, Jack S.; Wilson, Christopher B.
    PrintStatus: Not Checked OutLane Catalog Record
  • 2011
    Klein, Jerome O.; Maldonado, Yvonne; Nizet, Victor; Remington, Jack S.; Wilson, Christopher B.
    PrintStatus: Not Checked OutLane Catalog Record
  • 2010 ClinicalKey
    Calandra, Thierry; Cohen, J.; Opal, Steven M.; Powderly, William G.
    Also available: Print – v. 1-2, 2010.
  • 2004 Ovid
    Bartlett, John G.; Blacklow, Neil R.; Gorbach, Sherwood L.
    Also available: Print – 2004
  • 2007
  • 2005 Springer
    Schreiner, Christoph; Winer, Jeffery A.
  • 2013
    Beauchamp, Kyle A.; Das, Rhiju; Harbury, Pehr A. B.; Martinez, Todd J.; Pande, Vijay.
    An atomic-scale understanding of biological molecules remains a grand challenge for the physical and biological sciences. Here, I describe how molecular dynamics simulations can be used to directly connect to biophysical experiments. I first describe the use of Markov state models to connect simulated and measured protein kinetics, allowing studies of protein folding at the atomic scale. I then introduce the use of NMR measurements, such as chemical shifts and scalar couplings, for the evaluation of molecular dynamics force field quality. Finally, I propose a new statistical technique that can be used to combine both simulation and experiment into accurate models of conformational ensembles. Such models are shown to be free of force field bias and can be used to investigate the structural and equilibrium properties of biomolecules. In sum, the present work demonstrates how statistically-sound methods of inference can forge a direct connection between simulation and experiment.
  • 2013
    Lockwood, Jeffrey Alan.
    PrintStatus: Not Checked OutLane Catalog Record
    Exploring the nature of anxiety and phobia, Lockwood explores the lively debate about how much of our fear of insects can be attributed to ancestral predisposition for our own survival and how much is learned through individual experiences. Drawing on vivid case studies, Lockwood explains how insects have come to infest our minds in sometimes devastating ways and supersede even the most rational understanding of the benefits these creatures provide.
  • 2013 Springer Protocols
    De Nardo, Christine M.; Latz, Eicke.
    Assessing [beta]-amyloid-induced NLRP3 inflammasome activation in primary microglia / Mareike Schnaars, Hannes Beckert, and Annett Halle -- Activating the NLRP3 inflammasome using the amyloidogenic peptide IAPP / Clara Westwell-Roper [and others] -- Assessment and quantification of crystal-induced lysosomal damage / Peter Duewell and Eicke Latz -- Assessment of inflammasome activation in primary human immune cells / Theo S. Plantinga, Leo A.B. Joosten, and Mihai G. Netea -- NLRP3 inflammasome activation and cytotoxicity induced by particulate adjuvants / Marie Yang [and others] -- Measuring inflammasome activation in response to bacterial infection / Petr Broz and Denise M. Monack -- Detection of pyroptosis by measuring released lactate dehydrogenase activity / Manira Rayamajhi, Yue Zhang, and Edward A. Miao -- ASC speck formation as a readout for inflammasome activation / Andrea Stutz [and others] -- Immunoblotting for active caspase-1 / Christopher Jakobs [and others] -- Inflammasome activation and inhibition in primary murine bone marrow-derived cells, and assays for IL-1[alpha], IL-1[beta], and caspase-1 / Katharina S. Schneider, Christina J. Thomas, and Olaf Gross -- Reconstituting the NLRP1 inflammasome in vitro / Benjamin Faustin and John C. Reed -- Assessing ATP binding and hydrolysis by NLR proteins / Jinyao Mo and Joseph A. Duncan -- Blue native polyacrylamide gel electrophoresis to monitor inflammasome assembly and composition / Eric M. Kofoed and Russell E. Vance -- Analysis of microbiota alterations in inflammasome-deficient mice / Eran Elinav, Christoph A. Thaiss, and Richard A. Flavell -- Quantification of adipose tissue leukocytosis in obesity / Ryan Grant [and others] -- In vivo evaluation of neutrophil recruitment in response to sterile particulates / Tamiko Yanagida, Kaoru Orihashi, and Hajime Kono.
  • 2011 Springer
    Couillin, Isabelle; Martinon, Fabio; Pétrilli, Virginie.
  • 2014 ScienceDirect
    Bagchi, Debasis; Rahman, Irfan.
    The book provides a comprehensive overview to understanding the integrated impact of the concepts of cellular and molecular aspects, models, environmental factors, and lifestyle involved in premature aging. Additionally, it examines how functional food, dietary nutraceuticals or pharmacological compounds can reverse inflammation and premature aging based on personalized medicine. This book is a valuable resource for health professionals, scientists and researchers, nutritionists, health practitioners, students and for all those who wish to broaden their knowledge in the allied field.
  • 2012 Springer
    Grundtman, Cecilia; Wick, G.
    Ch. 1. Historical reflections on the inflammatory aspects of atherosclerosis -- Ch. 2. Morphology of atherosclerotic lesions -- Ch. 3. Clinical manifestations of atherosclerosis -- Ch. 4. Intra-aortic hematopoietic cells -- Ch. 5. The vascular-associated lymphoid tissue (VALT) -- Ch. 6. Vascular endothelial cells as immunological targets in atherosclerosis -- Ch. 7. The role of adhesion molecules and intimal dendritic cells in the initiation of atherosclerosis -- Ch. 8. Animal models of atherosclerosis -- Ch. 9. A Darwinian-evolutionary concept for atherogenesis: the role of immunity to HSP60 -- Ch. 10. Mediators of vascular inflammation -- Ch. 11. Pentraxins and atherosclerosis -- Ch. 12. Interleukin-33 and atherosclerosis -- Ch. 13. Proteomics of atherosclerosis -- Ch. 14. Adipokines, inflammation, and atherosclerosis -- Ch. 15. Natural antibodies and atherosclerosis -- Ch. 16. NK/NKT cells and atherosclerosis -- Ch. 17. Macrophages and atherosclerosis -- Ch. 18. Host pattern recognition receptors (toll-like receptors, RIG-I-Like receptors, NOD-like receptors) and atherosclerosis -- Ch. 19. Humoral antibodies -- Ch. 20. Adaptive T Cell immunity -- Ch. 21. Immunity to low-density lipoprotein -- Ch. 22. Extracellular matrix and smooth muscle cells -- Ch. 23. The role of infection in atherosclerosis and in plaque stability -- Ch. 24. Inflammatory biomarkers -- Ch. 25. Atherosclerosis in rheumatic diseases -- Ch. 26. Anti-inflammatory therapeutic approaches -- Ch. 27. Vaccination against atherosclerosis -- Ch. 28. Endocrinological aspects of atherosclerosis -- Ch. 29. Imaging of atherosclerosis -- Ch. 30. Future directions of atherosclerosis research and translation into clinical application -- Ch. 31. Controversies and open questions -- Index.
  • 2014 Springer
    Aggarwal, Bharat B.; Gupta, Subash Chandra; Sung, Bokyung.
    The role of inflammation in lung cancer / Mónica Gomes, Ana Luísa Teixeira, Ana Coelho, António Araújo and Rui Medeiros -- The role of inflammation in colon cancer / Naveena B. Janakiram and Chinthalapally V. Rao -- The role of inflammation in inflammatory breast cancer / Tamer M. Fouad, Takahiro Kogawa, James M. Reuben and Naoto T. Ueno -- The role of inflammation in brain cancer / James L. Sowers, Kenneth M. Johnson, Charles Conrad, Joel T. Patterson and Lawrence C. Sowers -- The role of inflammation in head and neck cancer / Marcelo Bonomi, Alexis Patsias, Marshall Posner and Andrew Sikora -- The role of inflammation in pancreatic cancer / Simone Hausmann, Bo Kong, Christoph Michalski, Mert Erkan and Helmut Friess -- The role of inflammation in prostate cancer / Karen S. Sfanos, Heidi A. Hempel and Angelo M. De Marzo -- The role of inflammation in bladder cancer / Georgios Gakis -- The role of inflammation in kidney cancer / Antonio Roma De Vivar Chevez, James Finke and Ronald Bukowski -- The role of inflammation in gastric cancer / Kazim Senol, Murat Bulut Özkan, Selahattin Vural and Mesut Tez -- The role of inflammation in sarcoma / Jürgen Radons -- The role of inflammation in lymphoma / Antonino Carbone, Claudio Tripodo, Carmelo Carlo-Stella, Armando Santoro and Annunziata Gloghini -- The role of inflammation in leukaemia / Janusz Krawczyk, Michael O'Dwyer, Ronan Swords, Ciara Freeman and Francis J Giles -- The role of inflammatory cells in angiogenesis in multiple myeloma / Domenico Ribatti and Angelo Vacca -- The role of inflammation in cervical cancer / S. Deivendran, K. Hezlin Marzook and M. Radhakrishna Pillai -- The role of inflammation in liver cancer / Anupam Bishayee -- The role of inflammation in skin cancer / Girish B. Maru, Khushboo Gandhi, Asha Ramchandani and Gaurav Kumar.
    Also available: Print – 2014
  • v. 1-2, 2009 Springer Protocols
    v. 2, 2009 Springer Protocols
    Kozlov, Serguei V.
    v. 1. Experimental models and practical approaches -- v. 2. Molecular analysis and pathways.
  • 2011 Springer
    Jankowski, Janusz A. Z.
    Basic concepts of inflammation and its role in carcinogenesis -- Inherited syndromes predisposing to inflammation and GI cancer -- Stem cells and inflammation in the intestine -- Acid reflux and oesophageal cancer -- Helicobacter pylori and gastric cancer -- Inflammatory bowel disease and colon cancer -- Primary sclerosing cholangitis -- Chronic inflammation and hepatocellular carcinoma -- Gastrointestinal cancer: current screening strategies -- Targeted drug therapies and cancer -- Genetics of inflammation in the gastrointestinal tract and how it can cause cancer -- Endoscopic methods.
  • 2010 Springer
    Adamis, Anthony P.; Lambris, J. D.
    The case for complement and inflammation in AMD : open questions / Natalia Karagianni and Anthony P. Adamis -- The role of complement in AMD / Peter F. Zipfel, Nadine Lauer, and Christine Skerka -- Multiple interactions of complement factor H with its ligands in solution : a progress report / Stephen J. Perkins ... [et al.] -- Genetic control of complement activation in humans and age related macular degeneration / Laura A. Hecker and Albert O. Edwards -- Bisretinoids of RPE lipofuscin : trigger for complement activation in age-related macular degeneration / Janet R. Sparrow -- The role of the classical complement cascade in synapse loss during development and glaucoma / Allison M. Rosen and Beth Stevens -- A role for complement in glaucoma? / Lizhen Ren and John Danias -- The ATP-binding cassette transporter ABCA4 : structural and functional properties and role in retinal disease / Yaroslav Tsybovsky, Robert S. Molday, and Krzysztof Palczewski -- Suppression of drusen formation by compstatin, a peptide inhibitor of complement C3 activation, on cynomolgus monkey with early-onset macular degeneration / Zai-Long Chi ... [et al.] -- A targeted inhibitor of the complement alternative pathway reduces RPE injury and angiogenesis in models of age-related macular degeneration / Bärbel Rohrer ... [et al.] -- Complement depletion with humanized cobra venom factor in a mouse model of age-related macular degeneration / David C. Fritzinger ... [et al.]
    Also available: Print – 2010
  • 2014 Springer
    Thomas, Madhavi.
    Inflammation in Parkinson's Disease brings advances in research together with current literature and evidence. This concise volume covers the fundamentals of neuroimmunology and inflammatory models, the interactions between pathways of neurodegeneration and follows the concept of research work undertaken from basic science to clinical trials. Researchers, clinicians, and students interested in Parkinson's Disease are provided with a comprehensive view of translational research methods and an insight needed for developing future therapies aimed at disease modulation.
  • 2013 Karger
    Halaris, Angelos; Leonard, B. E.
    Basic aspects of the immunology of neuroinflammation / Wohleb, E.S.; Godbout, J.P. -- Stress and neuroinflammation / Grippo, A.J., Scotti, M.-A.L. -- Role of inflammation in depression : implications for phenomenology, pathophysiology and treatment / Raison, C.L., Miller, A.H. -- Virus infection as a cause of inflammation in psychiatric disorders / Bechter, K. -- Inflammation, neurotoxins and psychiatric disorders / Myint, A.-M. -- Essential fatty acids as potential anti-inflammatory agents in the treatment of affective disorders / Song, C. -- The brain-gut axis : a target for treating stress-related disorders / Scott, L.V., Clarke, G., Dinan, T.G. -- The question of pro-inflammatory immune activity in schizophrenia and the potential importance of anti-inflammatory drugs / Arolt, V., Ambrée, O. -- Inflammation as the cause of the metabolic syndrome in depression / Leonard, B.E. -- Glucocorticoids and inflammation : a double-headed sword in depression? / Horowitz, M.A. ... [et al.] -- Co-morbidity between cardiovascular pathology and depression : role of inflammation -- Halaris, A. -- Inflammatory and oxidative and nitrosative stress cascades as new drug targets in myalgic encephalomyelitis and chronic fatigue syndrome -- Maes, M. -- Peripheral inflammation and cognitive aging -- Lim, A., Krajina, K., Marsland, A.L. -- Inflammation in suicidality : implications for novel treatment options / Janelidze, S., Brundin, L.
  • 2007 Springer
    Harris, Randall E.
  • 2012 CRCnetBASE
    Aggarwal, Bharat B.; Guha, Sushovan; Krishnan, Sunil.
    "Oxidative stress and inflammation are among the most important factors of disease. Chronic infections, obesity, alcohol and tobacco usage, radiation, environmental pollutants, and high-calorie diets have been recognized as major risk factors for a variety of chronic diseases from cancer to metabolic diseases. All these risk factors are linked to chronic diseases through inflammation. While short-term, acute inflammation generated by the immune system serves a therapeutic role, chronic low-level inflammation that may persist "silently" for decades is responsible for chronic diseases. Inflammation, Lifestyle, and Chronic Diseases: The Silent Link describes the role of dysregulated inflammation in persistent and recurring diseases. It investigates links to lifestyle and presents research on how the suppression of proinflammatory pathways may provide opportunities for both prevention and treatment of chronic diseases. The book covers neurodegenerative diseases, pulmonary diseases, asthma, rheumatic and arthritic diseases, skin disease, heart disease, chronic wounds, infectious disease, neuropsychiatric disorders such as depression, gastrointestinal diseases, insulin resistance, and cancer, many of which are also diseases of old age. For each chronic disease, contributors review the clinical and scientific literature and examine current and potential therapies, including conventional pharmacotherapies as well as natural products. Noting that the long-term use of steroids and nonsteroidal anti-inflammatory drugs (NSAIDs) can cause adverse side effects, many of the chapters address the role of dietary agents such as fruits, vegetables, legumes, pulses, nuts, and spices as ideal anti-inflammatory agents that can be consumed regularly. The book also suggests directions for further research. Clinical and science researchers, students, and health professionals interested in the link between inflammation, lifestyle, and chronic diseases will find this an informative resource"--Provided by publisher.
  • 2014 CRCnetBASE
    Kong, Ah-Ng Tony.
    Section I. Inflammation, oxidative stress, nutritional phytochemicals, and cancer -- section II. Signal transduction, molecular targets, and biomarkers of dietary cancer-preventive phytochemicals -- section III. In vivo absorption and pharmacokinetics of nutritional phytochemicals -- section IV. Vitamins A, D, and E cancer prevention and clinical perspective -- section V. Omega-3 and omega-6 fatty acids -- section VI. Flavonoids and polyphenols -- section VII. Garlic organosulfur compounds and crucifer glucusinolates -- section VIII. Selenium, herbal medicines, alpha lipoic acid, and cancer prevention -- section IX. Epigenetics and chronic inflammation.
  • 2003 Springer Protocols
    Willoughby, D. A.; Winyard, Paul G.
    Ikappab kinase and nf-kappab signaling in response to pro-inflammatory cytokines / M. Delhase -- Screening for inhibitors of transcription factors using luciferase reporter gene expression in transfected cells / D. Phippard and A.M. Manning -- Adhesion molecule expression on cytokine-stimulated human endothelial cells / S.L. Cuvelier and K.D. Patel -- Phagocytosis by inflammatory phagocytes: Experimental strategies for stimulation and quantification / M.R. Morris [and others] -- Cytosolic ca2+ measurement and imaging in inflammatory cells / S. Dewitt [and others] -- Detection and visualization of oxidase activity in phagocytes / M.B. Hallett, C. Cole and S. Dewitt -- Measurement of complement activation / T.E. Mollnes -- Measurement of matrix metalloproteinase activities in the medium of cultured synoviocytes using zymography / L. Troeberg and H. Nagase -- Measurement of aggrecanase-generated interglobular domain catabolites in the medium and extracts of cartilage explants using western blot analysis / C.E. Hughes, C.B. Little and B. Caterson -- In vitro model of human articular cartilage degradation / W.D. Shingleton -- Carrageenan-induced paw edema in the rat and mouse / C.J. Morris -- Pleural models of inflammation: Immune and nonimmune / A.R. Moore -- Models of acute inflammation in the ear / M. Gabor -- Migration of specific leukocyte subsets in response to cytokine or chemokine application in vivo / M. Perretti and S.J. Getting -- Inflammatory joint disease: Clinical, histological, and molecular parameters of acute and chronic inflammation and tissue destruction / N.L. McCartney-Francis, J. Chan and S.M. Wahl -- The assessment of inflammation, cartilage matrix, and bone loss in experimental monoarticular arthritis of the rat / M.P. Seed -- Collagen-induced arthritis / A.R. Moore -- Air-pouch models of inflammation and modifications for the study of granuloma-mediated cartilage degradation / P. Colville-Nash and T. Lawrence -- Quantitative analysis of angiogenesis using the murine chronic granulomatous air pouch / C.A. Alam -- Models of coronary artery occlusion and reperfusion for the discovery of novel antiischemic and antiinflammatory drugs for the heart / N.S. Wayman [and others] -- Assessment of anticolitic drugs in the trinitrobenzene sulfonic acid (tnbs) rat model of inflammatory bowel disease / B.J. Whittle, M. Cavicchi and D. Lamarque -- An in vivo model of ischemia/reperfusion and inflammation of the kidneys of the rat / P.K. Chatterjee and C. Thiemermann -- In vivo models of inflammation: Immune rejection and skin transplantation in vivo / I. Binet and K.J. Wood -- Wound healing: A model of dermal wound repair / A. Tomlinson and M.W. Ferguson -- An iconoclastic approach to pharmacodynamics in model systems: Their relevance to humans / D.R. Blake and G.J. Taylor -- Quantifying inflammation in vivo using radiolabeled antibodies and leukocytes / D. Marshall and D.O. Haskard -- Immunoperoxidase histochemistry for the detection of cellular adhesion molecule, cytokine, and chemokine expression in the arthritic synovium / Z. Szekanecz and A.E. Koch -- Roles of nitric oxide and superoxide in inflammation / D. Salvemini, H. Ischiropoulos and S. Cuzzocrea -- Analysis of nitrite and nitrate in the study of inflammation / C.A. Davies [and others] -- In vivo assays for cox-2 / C.C. Chan -- Measurement of 8-epi-pgf2alpha as a marker of lipid peroxidation in vivo by immunoaffinity extraction and gas chromatography-mass spectrometry / N.K. Gopaul and E.E. Anggard -- Laboratory assessment of the acute phase response: Using crp as a model / R.F. Ritchie and T.B. Ledue -- Assays of matrix metalloproteinases (mmps) and mmp inhibitors: Bioassays and immunoassays applicable to cell culture medium, serum, and synovial fluid / J.B. Catterall and T.E. Cawston.
  • 2015 Springer
    Scott, Ian C.; Galloway, James B.; Scott, David L.
    This evidence based book covers the key components in the diagnosis, assessment and management of inflammatory arthritis. The authors look at the epidemiology, pathology, clinical assessment and investigation of inflammatory arthritis patients, and provide an overview of currently available treatment options. With major changes seen in the way inflammatory arthropathies are diagnosed, classified, investigated and managed, Inflammatory Arthritis in Clinical Practice, Second Edition provides the reader with the most up-to-date developments in this area.
  • 2008 Springer
    Scott, David L.; Kingsley, Gabrielle H.; Scott, David L.
  • 2015 Springer
    Shaker, Reza; Stein, Daniel J.
  • 2003 Springer
    Karp, Loren C.; Shanahan, Fergus; Targan, Stephan R.
  • 2006 Springer
    Delaini, Gian Gaetano.
    Also available: Print – 2006
  • 2011 Springer
    Cohen, Russell D.
    The influence of twentieth-century biomedical thought on the origins of inflammatory bowel disease therapy / Joseph B. Kirsner -- The changing epidemiology of IBD / Anders Ekbom -- Recent advances in the genetics of IBD / Russell D. Cohen -- New paradigms in the pathogenesis of IBD / Giorgos Bamias, Theresa Pizarro, and Fabio Cominelli -- State of the art medical treatment of the adult patient with IBD : the mesalamine-based therapies / L. Campbell Levy and Corey A. Siegel -- State of the art medical treatment of the adult patient with IBD : modern use of corticosteroids / Wojciech Blonski, David Kotlyar, and Gary R. Lichtenstein -- State-of-the-art medical therapy of the adult patient with IBD : the immunomodulators / Dana Moffatt and Charles N. Bernstein -- State-of-the-art medical treatment of the adult patient with IBD : the biological therapies / Stephen B. Hanauer -- Prebiotics, probiotics, antibiotics, and nutritional therapies in IBD / Richard N. Fedorak, Levinus A. Dieleman, and Karen L. Madsen -- State-of-the-art management of the pediatric IBD patient / Marla Dubinsky -- Innovations in the surgical treatment of inflammatory bowel disease / Roger Hurst -- Clinical utility of serological markers and thiopurine drug monitoring in IBD : an evidence-based review / Raja Tamaz and Ernest G. Seidman -- Caring for women with inflammatory bowel disease / Sunanda Kane and Rebecca Kowalczyk -- Novel radiographic techniques in IBD patients / V. Anik Sahni and Koenraad J. Mortele -- Novel techniques in the diagnosis of inflammatory bowel disease / Shabana F. Pasha and Jonathan A. Leighton -- Inflammatory bowel disease pathology slideshow / Christopher R. Weber -- New findings in the diagnosis and prevention of colorectal cancer in IBD / David T. Rubin and Jami A. Rothe -- Managing the patient with a fecal diversion / Janice C. Colwell -- The new economic reality in the world of IBD / Nanda Venu and Russell D. Cohen.
  • 2013 Springer
    Arce-Salinas, Claudia; Garza-Salazar, Jaime G. de la; Meneses García, Abelardo.
    Inflammatory breast cancer is a rare and aggressive form of breast cancer that occurs in women of all ages, and, rarely, in men. Variable disease presentation means that this disease is often undetected and patients with this diagnosis have a poor prognosis.Inflammatory Breast Cancer brings together the existing clinical information on inflammatory breast cancer. The content covers epidemiology, risk factors, diagnosis, histopathology and staging, therapy and management of patients with this disease. Recent advances in therapy have improved the prognosis of this type of cancer considerably, making this text a timely addition to the literature.This book is an essential tool for medical, surgical and clinical oncologists specialising in breast cancer, who will inevitably encounter this rare but pernicious disease.
  • 2012 Springer
    Cristofanilli, Massimo; Ueno, Naoto T.
    Introduction: Why IBC Now? / Naoto T. Ueno and Massimo Cristofanilli -- Epidemiology of Inflammatory Breast Cancer / Shannon Wiggins, Sarah Taylor and Melissa Bondy -- Clinical Aspect of Inflammatory Breast Cancer: Diagnosis, Criteria, Controversy / Shaheenah Dawood and Vicente Valero -- Inflammatory Breast Cancer Registry / Jie S. Willey and Naoto T. Ueno -- Pathology: Histomorphometrical Features of IBC - Angiogenesis, Lymphangiogenesis, and Tumor Emboli / Sanford H. Barsky and Fredika M. Robertson -- Imaging for the Diagnosis and Staging of IBC / Wei Tse Yang -- Surgical Therapy for Inflammatory Breast Cancer / Sarah M. Gainer, Hideko Yamauchi and Anthony Lucci -- Radiation Therapy for Inflammatory Breast Cancer / Thomas A. Buchholz, Ian Bristol and Wendy Woodward -- Systemic and Targeted Therapy / Hideko Yamauchi, Teruo Yamauchi, Naoto T. Ueno and Vicente Valero -- Inflammatory Breast Cancer: Chemotherapy of Metastatic Disease / Anthony Gonçalves and Patrice Viens -- The Role of the Multidisciplinary Team in Inflammatory Breast Cancer / Nabila Chowdhury and Sandra M. Swain -- High-Dose Chemotherapy with Autologous Hematopoietic Stem Cell Transplantation in Inflammatory Breast Cancer / Yee Chung Cheng and Naoto T. Ueno -- Models of Inflammatory Breast Cancer / Lara Lacerda and Wendy A. Woodward -- Signaling Pathways in Inflammatory Breast Cancer / Dongwei Zhang and Naoto T. Ueno -- Molecules That Drive the Invasion and Metastasis of Inflammatory Breast Cancer / Madhura Joglekar and Kenneth L. van Golen -- Inflammatory Mediators as Therapeutic Targets for Inflammatory Breast Cancer / Fredika M. Robertson, Khoi Chu, Rita Circo, Julia Wulfkuhle and Lance Liotta, et al. -- Immunology of Inflammatory Breast Cancer / James M. Reuben and Bang-Ning Lee -- Angiogenesis and Lymphangiogenesis in IBC: Insights from a Genome-Wide Gene Expression Profiling Study / Peter B. Vermeulen, Gert Van den Eynden, Pascal Finetti, Daniel Birnbaum and Naoto T. Ueno, et al. -- Microarray Analysis Identifies an Expression Signature for Inflammatory Breast Cancer / François Bertucci, Pascal Finetti, Max Chaffanet, Patrice Viens and Daniel Birnbaum -- Cell Gene Expression Signatures in Inflammatory Breast Cancer / Wendy A. Woodward -- The Effect of Systemic Chemotherapy on Minimal Residual Disease in the Blood and Bone Marrow of Patients with Inflammatory Breast Cancer / Luc Y. Dirix, Dieter Peeters, Steven Van Laere and Peter B. Vermeulen -- Perspective of Patient Advocacy / Michelle Esteban and Patti Bradfield.
  • 2010
    Noutsias, Michel; Schultheiss, H. -P.
    PrintStatus: Not Checked OutLane Catalog Record
  • 2011 Springer
    Billings, Steven D.
    Spongiotic dermatitis -- Psoriasiform dermatitis -- Interface dermatitis -- Perivascular dermatitis -- Vasculitis and thrombotic disorders -- Nodular and diffuse dermatitis -- Palisading granulomatous dermatitis -- Sclerosing dermatitis -- Bullous dermatitis -- Panniculitis -- Infections -- Miscellaneous dermatoses: invisible dermatoses and inflammatory processes that clinically mimic tumors.
  • 2010 Springer
    Smoller, Bruce R.; Hiatt, Kim M.
    Superficial perivascular dermatitis -- Lichenoid/vacuolar dermatitis -- Superficial perivascular dermatitis with spongiotic epidermal changes -- Superficial perivascular dermatitis with psoriasiform epidermal changes -- Superepidermal blistering processes -- Intraepidermal blisters -- Granulomatous dermatitis -- Cutaneous vasculitis -- Alopecias -- Panniculitis -- Histologic mimics of cutaneous lymphoma -- Dermal pigmentary disorders -- Dermal deposition disorders without pigment.
  • 2013 Springer
    Hähnel, Stefan.
    Inflammatory diseases of the CNS are playing an increasingly important role in the clinical practice of neuroradiology. Neuroimaging contributes greatly to the differentiation of infectious (e.g., viral encephalitis and pyogenic brain abscess) and noninfectious (e.g., multiple sclerosis) inflammatory brain diseases and to the distinction between brain inflammation and other brain diseases, e.g., neoplastic or ischemic. This second, updated edition of Inflammatory Diseases of the Brain provides a comprehensive overview of the field from a neuroradiological point of view. In order to ensure a standardized approach throughout the book, each disease-oriented chapter is again subdivided into three principal sections: epidemiology, clinical presentation, and therapy; imaging; and differential diagnosis. A separate chapter addresses technical and methodological issues and imaging protocols. An important focus of the book is the current role of advanced MR imaging techniques, such as diffusion and perfusion MRI and MR spectroscopy, in the differentiation of inflammatory and other brain diseases. All of the authors are recognized experts, and the numerous high-quality and informative illustrations include some not contained in the first edition. This book will be of great value not only to neuroradiologists but also to neurologists, neuropediatricians, and general radiologists.
  • 2015 Springer
    Pokorski, Mieczyslaw.
    The mechanistic basis of chronic inflammation remains unclear. The research sheds new light on the immune cells expressing the activation markers HLA-DR and regulatory T cells (Tregs) and the cells expressing Siglec receptors as being key players in the immune system responsiveness to antigens and thus in lung tissue damage of chronic inflammation. The results help understand the mechanisms of action of common drugs used in COPD, such as formoterol, tiotropium, or corticosteroids, and point to novel drug targets. The chapters also deal with brain damaging effects, by far unrecognized, of inhaled corticosteroid therapy, a time-proven management of chronic inflammatory airway conditions; asthma being a case in point. Novel methods, likely less producing side effects, of macrolide antibiotics administration by inhalation are discussed, emphasizing not only bacteriostatic but also anti-inflammatory action.
    Also available: Print – 2015
  • 2005 Springer
    Alexander, J. Steven; Minagar, Alireza.
    Endothelial cell-leukocyte interactions during CNS inflammation / J. Steven Alexander and Alireza Minagar -- Interactions of the CNS and immune system / Monica J. Carson, Crystal S. Anglen, and Corinne Ploix -- Cytokines and brain : health and disease / Tammy Kielian and Paul D. Drew -- Chemokines and central nervous system disorders / William J. Karpus -- Circulating cell-derived microparticles in thrombotic and inflammatory disorders / Wenche Jy ... [et al.] -- Multiple sclerosis : clinical features, immunopathogenesis, and clinical management / William A. Sheremata -- Neuroprotective effects of interferon-b in multiple sclerosis / Fabrizio Giuliani, Rana Zabad, and V. Wee Yong -- Acute disseminated encephalomyelitis / Sean J. Pittock and Dean M. Wingerchuk -- Ingested type interferon in experimental autoimmune encephalomyelitis / Staley A. Brod -- Neuromyelitis optica / Dean M. Wingerchuk -- Transverse myelitis : clinical manifestations, pathogenesis, and management / Douglas A. Kerr ... [et al.] -- Optic neuritis : pathogenesis, immunology, and clinical management / Rohit Bakshi and Robert Zivadinov -- Central nervous system vasculitis : pathogenesis, immunology, and clinical management / Shariq Mumtaz ... [et al.] -- Neurosarcoidosis : pathogenesis, immunology, and clinical management / Dakshinamurty Gullapalli and Lawrence H. Phillips II -- Neuropsychiatric SLE : pathogenesis, immunology, and clinical management / Deborah Aleman-Hoey and Robin Brey -- Gene expression in HIV-associated dementia / Paul Shapshak ... [et al.] -- Human T-lymphotropic virus-associated neurological disorders : pathogenesis, immunology, and clinical treatment / Michael Lairmore ... [et al.] -- West Nile virus infection of the nervous system : pathogenesis, immunology, and clinical management / Douglas J. Lanska.
  • 2009 Springer
    Kagen, Lawrence J.
    Evaluation of the patient -- Classification of idiopathic inflammatory myopathies -- Inflammatory milieu: cells and cytokines -- Juvenile dermatomyositis: an update on clinical and laboratory findings -- Inclusion body myositis -- Role of muscle biopsy in the diagnosis of inflammatory myopathy -- Electromyography -- Magnetic resonance imaging of myopathies and myositis -- Ultrasound in the evaluation of the inflammatory myopathies -- Serological findings -- Antisynthetase syndrome -- Pulmonary manifestations of inflammatory myopathy -- Dermatological manifestations of dermatomyositis -- Differential diagnosis of inflammatory myopathy -- Outcomes and assessment for inflammatory muscle disease -- Muscle strength and exercise in patients with inflammatory myopathies -- Risk of malignancy in patients with dermatomyositis and polymyositis -- Treatment.
  • 2015 Springer
    Pugia, Michael.
    Part 1. Introduction -- 1. Impact of inflammation and the innate immunity response in obesity mediated diabetes (lit review) -- Part 2. Impact of complement on diabetic disease -- 2. Complement and Complement Regulatory Proteins in Diabetes -- Part 3. Role of C terminal fragment of adiponectin receptor in inhibition of insulin degradation -- 3. Development of adiponectin receptor C terminal fragment bioassays -- 4. Protease inhibition and biological distribution of the C terminal fragment of adiponectin receptor -- 5. Cell & biological models for the C terminal fragment of adiponectin receptor -- 6. C-Terminal fragment of adiponectin receptor clinical correlations -- Part 4. Uristatin assay for prediction of renal and other clinical events -- 7. Uristatin immunoassay usage in glomerular nephritis assessment -- 8. Acute Response of Uristatin in Surgery -- 9. Cardiovascular and metabolic syndrome impact on uristatin -- 10. Uristatin anti-inflammatory cellular signaling -- Part 5. Summary -- 11. Overview of progress in new markers for diabetes inflammation (Literatue Review).
    Also available: Print – 2015
  • 2013 Springer
    Gabriel, Edmo Atique; Gabriel, Sthefano Atique.
    Part I: General Topics. Neuroendocrine Response and Shock / Riad N. Younes, Fernando C. Abrão -- The Role of Lymphocytes in the Pathogenesis of Atherosclerosis: Focus on CD4+ T Cell Subsets / Ingrid E. Dumitriu -- Immunological Mechanisms of Inflammation / Nilo José Coêlho Duarte, Cyro Alves de Brito, Alberto José da Silva Duarte -- Part II: Carotid Diseases. Role of Lipoproteins in Carotid Arterial Disease / Efthymios D. Avgerinos, Christos D. Liapis -- Carotid Endarterectomy: Inflammatory Aspects / Sthefano Atique Gabriel, Edmo Atique Gabriel -- Endovascular Treatment of Carotid Disease: Inflammatory Aspects / Sthefano Atique Gabriel, Edmo Atique Gabriel -- Part III: Abdominal Aortic Aneurysm. Role of Matrix Metalloproteinases and Aortic Wall Degradation in Abdominal Aortic Aneurysms / George A. Antoniou, George S. Georgiadis -- Role of Haptoglobin in Abdominal Aortic Aneurysm / Valerio Napolioni -- Inflammatory Aortic Aneurysm / Guilherme Vieira Meirelles -- Endovascular Treatment of Abdominal Aortic Aneurysms: Current Approaches and New Devices / Armando de Carvalho Lobato, Robert Guimarães do Nascimento --
  • 2011
    Shluzas, Lauren Marie Aquino; Leifer, Larry J.; Linehan, John H.; Steinert, Ralf Martin; Sutton, Robert I.
    Through an inductive, multi-case analysis, this dissertation examines how design and development practices, involving physicians and medical device developers, influence the clinical and financial outcomes of early stage medical device companies. This research was motivated by an interest in understanding the role of physicians in the device development process, specifically in terms of how physician interaction influences the acceptance or rejection of new medical products. An analytic framework for case-based research was first developed based on exploratory interviews with leaders in the medical device field. Retrospective case studies were then conducted on eight entrepreneurial firms (four rival pairs) in the areas of pulse oximetry, robotic surgery, cardiac bypass surgery, and minimally invasive spine surgery. Primary data sources included interviews with engineers, physicians, and business executives from each company; product development data including device prototypes, regulatory clearance data, and intellectual property (IP); and clinical and financial outcomes data. Following the period of data collection, within-case and across-case analyses were performed. The interview data for each case was coded for design and development practices involving physician-developer interaction, using NVivo qualitative analysis software (QSR International, Version 8). Development practices were analyzed using logic models to examine causal relationships between practices, and product and company outcomes. Design and development practices were further examined and supported using a combination of qualitative and quantitative evidence. Based on the multi-case analysis, this dissertation provides an overview of physician-developer interaction characteristics throughout each phase of the medical device development process. This includes a description of the roles and responsibilities of physicians engaged in development efforts, and their corresponding team affiliations. The research also illustrates four key factors that contributed to medical device adoption for the cases studied. First, the data highlight that designing products under variable use conditions (i.e. with variable patient populations and physicians of varying skill levels), enabled firms to optimize products for widespread clinical use and to increase the predictability of product outcomes. Second, the study shows that product adoption relied on maximizing benefits for multiple product stakeholders, while minimizing required changes in physician behavior. The data further illustrate that total benefit to product stakeholders was influenced to the greatest degree by benefits afforded to hospitals and physicians, assuming patient benefit was greater than or equal to the standard of care. Third, the study highlights that managing perceptions toward product use through performance data positively influenced product adoption to a greater degree than did market demand or regulatory clearance. Fourth, rival explanations for outcomes, involving limited physician interaction, indicate that competitive advantages were achieved through maintaining dominant financial and intellectual property positions. From these findings, the Insight-Value-Perception (iVP) Model for user-centered medical device design was constructed. The model links design and development practices to outcomes, from a combination of consumer-oriented, technical, and financial perspectives. This research provides theoretical contributions to product development and user-centered design literature, and provides practical contributions for developers in the medical device field. A contribution to product development literature is made through documenting the combined benefits of maximizing product value for stakeholders while managing data-driven perceptions toward product use. For the field of user-centered design, this research captures the benefits of designing medical technology with and for a broad consortium of product end-users, as opposed to industry leaders alone. The research also documents the importance of identifying the often-conflicting needs of product stakeholders, and then optimizing devices to satisfy the needs of those with the greatest influence over product use and adoption. For medical device practitioners, this dissertation provides design, regulatory, and product-testing strategies shown to increase technology adoption across the eight cases studied. From this thesis, the author proposes future studies to inform policies and strategies for device manufacturers and the FDA, and to advance knowledge in the fields of user-centered design and product development.
  • 2007
    Beer, Shelly.
    PrintStatus: Not Checked OutLane Catalog Record
  • 2007 Springer
    Fagot-Largeault, Anne; Rahman, Shahid; Torres, Juan Manuel.
    Pt. 1. Genetics and the life sciences -- Pt. 2. Genetics and philosophy of science: the reductionism debate and beyond -- Pt. 3. Genetics and the ethical, legal and sociological debate.
  • 2013
    Kent, Susan Kingsley.
    Appearing in the midst of the First World War, the influenza virus of 1918-1919 blazed across the globe in a matter of months, leaving in its wake a death toll that would surpass that of the war itself. It appeared suddenly and with explosive impact, and defied all previous understandings of the disease: the illness struck quickly and without warning, felling people in their homes, at work, and in the streets, and unlike previous manifestations of the disease, which tended to take infants and the elderly, this strain primarily struck men and women in the prime of their lives. Especially virulent, it moved quickly through homes, military barracks, cities, and towns, first appearing in the American Midwest and quickly making its way to South America, Africa, Europe, Asia, and Australia. Doctors and other medical professionals were helpless to understand or treat it, and governments were unable to contain or manage it. By the time the virus died out in the fall of 1919, it had taken the lives of up to sixty million people. Like the war, the pandemic shook the foundations of individuals, families, and entire societies around the globe, and its impact would continue to be felt throughout the first half of the twentieth century.
  • 2014 Springer
    Compans, Richard W.; Oldstone, Michael B. A.
    This two-volume work covers the molecular and cell biology, genetics and evolution of influenza viruses, the pathogenesis of infection, resultant host innate and adaptive immune response, prevention of infection through vaccination and approaches to the therapeutic control of infection.. Experts at the forefront of these areas provide critical assessments with regard to influenza virology, immunology, cell and molecular biology, and pathogenesis. Volume I provides overviews of the latest findings on molecular determinants of viral pathogenicity, virus entry and cell tropism, pandemic risk assessment, transmission and pathogenesis in animal species, viral evolution, ecology and antigenic variation, while Volume II focuses on the role of innate and adaptive immunity in pathogenesis, development of vaccines and antivirals.
  • 2015 Springer
    Compans, Richard W.; Oldstone, Michael B. A.
    Part I. Innate immunity. The role of cytokine responses during influenza virus pathogenesis and potential therapeutic options / John R. Teijaro -- Innate immune sensing and response to influenza / Bali Pulendran and Mohan S. Maddur -- The NS1 protein: a multitasking virulence factor / Juan Ayllon and Adolfo García-Sastre -- Role of NK cells in influenza infection / Stacey Shultz-Cherry -- Host detection and the stealthy phenotype in influenza virus infection / Pradyot Dash and Paul G. Thomas -- Part II. Vaccines and adaptive immunity. Inactivated and adjuvanted influenza vaccines / Giuseppe Del Giudice and Rino Rappuoli -- Live attenuated influenza vaccine / Hong Jin and Kanta Subbarao -- Design of alternative live attenuated influenza virus vaccines / Courtney Finch, Weizhong Li and Daniel R. Perez -- Rapid production of synthetic influenza vaccines / Philip R. Dormitzer -- Influenza neuraminidase as a vaccine antigen / Maryna C. Eichelberger and Hongquan Wan -- Advances in universal influenza virus vaccine design and antibody mediated therapies based on conserved regions of the hemagglutinin / Florian Krammer, Peter Palese and John Steel -- Structural characterization of viral epitopes recognized by broadly cross-reactive antibodies / Peter S. Lee and Ian A. Wilson -- Skin immunization with influenza vaccines / Ioanna Skountzou and Richard W. Compans -- Mucosal immunization and adjuvants / Hideki Hasegawa, Elly van Reit and Hiroshi Kida -- B cell responses to influenza infection and vaccination / Christopher Chiu, Ali H. Ellebedy, Jens Wrammert and Rafi Ahmed -- Memory CD4 T cells in influenza / Kyra D. Zens and Donna L. Farber -- The effector T cell response to influenza infection / Matthew M. Hufford, Taeg S. Kim, Jie Sun and Thomas J. Braciale -- Part III. New antiviral discovery. Antiviral effects of inhibiting host gene expression / Ralph A. Tripp and S. Mark Tompkins -- Index.
  • 2002 ScienceDirect
    Potter, C. W.
  • 2014 Future Med
    Oxford, J. S.
    Influenza surveillance / John S. Oxford -- Surveillance of influenza in swine and wildfowl / Ian H. Brown -- Global influenza surveillance: advances in technology / Mila C. González & Stephen S. Morse -- Ask the expert : origins of recent pandemics and lessons for surveillance / John S. Oxford -- Global seroepidemiology : value and limitations / Karen L. Laurie, Othmar G. Engelhardt, John Wood & Maria D. Van Kerkhove -- Influenza surveillance : interrupting transmission / Alan P. Zelicoff -- Pandemic influenza preparedness / Chloe Sellwood -- Multiple choice questions : answers.
  • 2008 Springer
    Del Giudice, Giuseppe; Rappuoli, Rino.
  • 2011 Springer
    Del Giudice, Giuseppe; Rappuoli, Rino.
    pt. 1. Evolution and epidemiology -- pt. 2. Immunity and vaccine strategies -- pt. 3. Economic and social implications.
  • 2012 Springer
    Itzstein, Mark von.
  • 2014 Springer
    Berner, Eta S.
    This book reviews and defines the current state of the art for informatics education in medicine and health care. This field has undergone considerable change as the field of informatics itself has evolved. Twenty years ago almost the only individuals involved in health care who had even heard the term "informatics" were those who identified themselves as medical or nursing informaticians. Today, we have a variety of subfields of informatics including not just medical and nursing informatics, but informatics applied to specific health professions (such as dental or pharmacy informatics), as well as biomedical informatics, bioinformatics and public health informatics. Informatics Education in Health Care addresses the broad range of informatics education programs available today. The Editor and very experienced internationally recognized informatics educators who have contributed to this work have made the tacit knowledge explicit and shared some of the lessons they have learned. This book therefore represents the key reference for all involved in the informatics education whether they be trainers or trainees.
  • 2005 Springer
    Cowan, Daniel F.
  • 2012 CRCnetBASE
    Kagadis, George C.; Langer, Steve G.
    Ontologies in the radiology department / Dirk Marwede -- Informatics constructs / Steve G. Langer -- Health level 7 imaging integration / Helmut König -- DICOM / Steven C. Horii -- Integrating the healthcare enterprise IHE / Steve G. Langer -- Operating systems / Christos Alexakos and George C. Kagadis -- Networks and networking / Christos Alexakos and George C. Kagadis -- Storage and image compression / Craig Morioka, Frank Meng, and Ioannis Sechopoulos -- Displays / Elizabeth A. Krupinski -- Digital X-ray acquisition technologies / John Yorkston and Randy Luhta -- Efficient database designing / John Drakos -- Web-delivered interactive applications / John Drakos -- Principles of three-dimensional imaging from cone-beam projection data / Frédéric Noo -- Multimodality imaging / Katia Passera, Anna Caroli, and Luca Antiga -- Computer-aided detection and diagnosis / Lioner T. Cheng, Daniel J. Blezek, and Brad J. Erickson -- Picture archiving and communication systems -- Brent K. Stewart -- Hospital information systems, radiology information systems, and electronic medical records / Herman Oosterwijk -- Procurement / Boris Zavalkovskiy -- Operational issues / Shawn Kinzel ... [et al.] -- Teleradiology / Dimitris Karnabatidis and Konstantinos Katsanos -- Ethics in the radiology department / William R. Hendee -- Imaging informatics beyond radiology / Konstantinos Katsanos ... [et al.] -- Informatics in radiation oncology / George Starkschall and Peter Balter.
  • 2005 CRCnetBASE
    Srivastava, Sudhir.
    Chapter 1. The Promise of Proteomics: Biology, Applications, and Challenges / Paul D. Wagner and Sudhir Srivastava -- Chapter 2. Proteomics Technologies and Bioinformatics / Sudhir Srivastava and Mukesh Verma -- Chapter 3. Creating a National Virtual Knowledge Environment.
  • 2014 CRCnetBASE
    Siochi, R. Alfredo C.; Starkschall, George.
    "A complete overview of the subject, this book discusses the role of information in the process of radiation oncology, acquisition, communication, and display of data; infrastructure requirements; and the use of data in clinical evaluation and research. It describes essential informatics tools, including various imaging techniques and image management systems, treatment planning systems, radiation oncology management systems, and the electronic medical record. Expert contributors explain how to obtain imaging and other diagnostic information as well as treatment prescriptions, treatment setup and delivery data, and outcome reviews"--Provided by publisher.
  • 2008 Springer
    Agosti, Maristella.
  • 2011 CRCnetBASE
    Groom, Frank M.; Jones, Stephan.
    Ch. 1. Healthcare systems : Introduction / Frank M. Groom -- Ch. 2. Technology as a catalyst for health enhancement / Jane Ellery and Peter J. Ellery -- Ch. 3. Health information exchange / Dave Yoder -- Ch. 4. Universal data standards / Colleen Willis -- Ch. 5. Healthcare information exchange / Kent Supancik -- Ch. 6. Health information technology in the United States : achieving legal and regulatory results that enhance innovation and adoption / Stuart N. Brotman, Gabriel G. Brotman and Jennifer E. Paul -- Ch. 7. Healthcare regulations, privacy, security, and information age considerations / Sydney Morris -- Ch. 8. Usability : patient-physician interactions and the electronic medical record / Carolyn K. Shue and Laura L.S. O'Hara -- Ch. 9. Remembering human factors when implementing technology use : a case study in home healthcare usability / Lori A. Byers -- Ch. 10. Security and privacy : impacts of evolving technologies and legislation / Robert Faix, Chad Cagnolatti, and David Flynn -- Ch. 11. New facility planning : a healthcare focus / Todd Hollowell and Carl Fleming -- Ch. 12. Developing innovative health information for youth : communication theory for practical emerging media applications / Lou Ann Stroup, Chelsey Sigler, and Jay E. Gillette -- Ch. 13. Re-envisioning the IndianaMedicaid.com website as a member-focused portal : a case study on usability and technology for transforming healthcare communication / Jared B. Linder -- Appendix: Glossary of health care terms from IBM.
  • 2008 Springer
    Primiero, Giuseppe.
  • 2010 CRCnetBASE
    Hristidis, Vagelis.
    Overview of XML / Fernando Farfan, Vagelis Hristidis -- Electronic health records / Fernando Farfan, Ramakrishna Varadarajan, and Vagelis Hristidis -- Overview of information discovery techniques on EHRs / Vagelis Hristidis -- Data Quality and integration issues in electronic health records / Ricardo Joao Cruz-Correia ... [et al.] -- Ethical, legal, and social issues for EHR data protection / Reid Cushman -- Searching electronic health records / Ramakrishna Varadarajan ... [et al.] -- Data mining and knowledge discovery on EHRs / Donald J. Berndt, Monica Chiarini Tremblay, and Stephen L. Luther -- Privacy-preserving information discovery on EHRs / Li Xiong ... [et al.] -- Real-time and mobile physiological data analysis / Daniele Apiletti ... [et al.] -- Medical image segmentation / Xiaolei Huang and Gavriil Tschpenakis.
  • 2007 Springer
    Furon, Teddy.
  • 2001 ScienceDirect
    Halpin, T. A.
  • 2009 ScienceDirect
    Gilbert, Steven G.; Hakkinen, Pertti J.; Mohapatra, Asish; Wexler, Philip.
  • 2012
    Taduri, Siddharth S.; Law, K. H.
    The recent years have seen a tremendous growth in research and developments in science and technology, and an emphasis in obtaining Intellectual Property (IP) protection for one's innovations. Information pertaining to IP for science and technology is siloed into many diverse sources and consists of laws, regulations, patents, court litigations, scientific publications, and more. Although a great deal of legal and scientific information is now available online, the scattered distribution of the information, combined with the enormous sizes and complexities, makes any attempt to gather relevant IP-related information on a specific technology a daunting task. In this thesis, we develop a knowledge-based software framework to facilitate retrieval of patents and related information across multiple diverse and uncoordinated information sources in the US patent system. The document corpus covers issued US patents, court litigations, scientific publications, and patent file wrappers in the biomedical technology domain. A document repository is to be populated with issued US patents, court cases, scientific publications, and file wrappers in XML format. Parsers are developed to automatically download documents from the information sources. Additionally, the parser also extracts metadata and textual content from the downloaded documents and populates the XML repository. A text index is built over the repository using Apache Lucene, to facilitate search and retrieval of documents. Based on the document repository, the underlying methodology to search across multiple information sources in the patent system is discussed. The methodology is divided into two major parts. First, we develop a knowledge-based query expansion methodology to tackle domain terminological inconsistencies in the documents. Relevant knowledge is retrieved from external sources such as domain ontologies. Since our goal is to retrieve a collection of relevant documents across multiple sources, we develop a patent system ontology to provide interoperability between the different types of documents and to facilitate information integration. We discuss the Information Retrieval (IR) framework which combines the knowledge-based query expansion methodology with the patent system ontology to provide a multi-domain search methodology. A visualization tool based on term co-occurrence is developed that can be used to browse the document repository through class hierarchies of domain ontologies. The knowledge-based query expansion methodology is evaluated through formal measures such as precision and recall. A simple term-based search is used as a baseline reference for comparison. Additionally, the results from related works are also used for comparison. A series of common questions asked during patent prior art searches and infringement analysis are generated to evaluate the patent system ontology. A summary of the results and analysis is provided.
  • 2002 CRCnetBASE
    Peltier, Thomas R.
  • 2011 Springer
    Dewan, Naakesh A.; Lorenzi, Nancy M.; Luo, John S.
    pt. 1. Overview -- pt. 2. Clinical practice issues -- pt. 3. Patient and client centric technologies section -- pt. 4. Organizational issues.
  • 2015 Springer
    Berliner, Leonard; Lemke, H. U.
    Preface -- Introduction -- The Digital Patient Model and Model Guided Therapy -- Hepatocellular Carcinoma and Patient Assessment -- Imaging in Hepatocellular Carcinoma: Radiologic Assessment -- Imaging in Hepatocellular Carcinoma: PET/CT -- Personalized Chemotherapy for Hepatocellular Carcinoma -- Surgical Treatment for Hepatocellular Carcinoma.- Minimally Invasive Therapies for Hepatocellular Cancer: Ablation Technologies -- Chapter 9 Minimally Invasive Therapies for Hepatocellular Cancer: Ablation Therapies -- Minimally Invasive Therapies for Hepatocellular Cancer:Catheter-Directed Therapies -- Radiation Oncology in the Treatment of Hepatocellular Carcinoma -- Design of an IT System for Hepatocellular Carcinoma -- Outlook and Expert Recommendations for Predictive, Preventive and Personalized Medicine and Hepatocellular Carcinoma.
  • 2013 Springer
    Goundrey-Smith, Stephen.
    Over the last 30-40 years, information technology (IT) has revolutionized professional life for millions of people around the world. IT has reduced the need for bulk storage of paper records by organizations, has enabled automation of tasks that were previously repetitive and labor-intensive, and carry them out in a fast and accurate way, has enabled economies of scale, improved efficiencies and enabled new ways of working that were hitherto impossible. In parallel with the rise of IT during the last 40 years, the role of the pharmacist - and the society in which pharmacists work - has changed considerably. Pharmacists are no longer principally compounders of medicines, but they are still responsible for ensuring that the patient receives the correct medicine, ensuring that the patient understands why they should take their medicine, and helping the patient with taking the medicine and being concordant with therapy.Information Technology in Pharmacy: an Integrated Approach provides a concise and practical general introduction to pharmacy IT, discusses issues surrounding the adoption of technology and how technologies may be utlilized by the pharmacy profession to exercise new professional roles and achieve new professional aspirations. This book will be of prime interest to practicing pharmacists at all levels, pharmacy students and pharmacy educators, but also to health informaticians, hospital and health care system administrators.
  • 2006 Springer
    Duplaga, Mariusz; Ingram, David; Zieliński, Krzysztof.
  • 2008 Springer
    Kerren, Andreas.
  • 2015 Springer
    Minor, Jessica.
    Introduction -- Predictive Genetic Testing -- The History and Components of Informed Consent -- Revised Model of Informed Consent -- Application of the Revised Model -- Conclusion.
  • 2015 Springer
    El Kossi, Mohsen; El Nahas, A. Meguid; Khwaja, Arif.
    Management of ADPKD -- Secondary Glomerular Disease Lupus Nephritis -- ANCA-Associated Vasculitis -- Acute Kidney Injury -- Chronic Kidney Disease -- Anaemia in Chronic Kidney Disease (CKD) -- Lipids and Chronic Kidney Disease -- Chronic Kidney Disease with Mineral and Bone Disorder (CKD-MBD) -- Diabetic Nephropathy -- Primary Glomerular Disease -- Hemodialysis -- Peritoneal Dialysis -- Transplantation.
  • 2005 NAP
  • 2010 IARC
    Ingested nitrate and nitrite -- 1. Exposure data -- 2. Studies of cancer in humans -- 3. Studies of cancer in experimental animals -- 4. Mechanistic and other relevant data -- 5. Summary of data reported -- 6. Evaluation and rationale -- -- Cyanobacterial peptide toxins -- 1. Exposure data -- 2. Studies of cancer in humans -- 3. Studies of cancer in experimental animals -- 4. Mechanistic and other relevant data -- 5. Summary of data reported -- 6. Evaluation and rationale
    Also available: Print – 2010
  • 2010 Springer
    Ribes, Ramón; Mannucci, P. M.; Ros, Pablo R.
  • 2006 CRCnetBASE
    Gaonkar, Anilkumar G.; McPherson, Andrew.
  • 2007
    Hickey, Anthony J.
    PrintStatus: Not Checked OutLane Catalog Record
  • 2006 CRCnetBASE
    Katz, Sidney A.; Salem, Harry.
    Also available: Print – 2006
  • 2015 CRCnetBASE
    Katz, Sidney A.; Salem, Harry.
    Chapter 1. Collection and characterization of particulate matter deposition / Gregor Jereb, Sidney A. Katz, and Borut Poljésak -- chapter 2. Nose-only aerosol exposure systems : design, operation, and performance / Robert F. Phalen, Loyda B. Mendez, and Michael J. Oldham -- chapter 3. Lungs-on-a-chip / Shuichi Takayama, Joshua B. White, and Chao Zhang -- chapter 4. Human health risk assessment of inhaled materials / Rhian B. Cope, Patricia Nance, and Mike Dourson -- chapter 5. Application of inhalation toxicology concepts to risk and consequence assessments / Brian E. Hawkins, David J. Winkel, Patrick H. Wilson, and Ian C. Whittaker -- chapter 6. Time scaling of dose and time to response : the toxic load exponent / Juergen Pauluhn -- chapter 7. Improper use of Haber's Law results in erroneous fatality estimation from predictive models / Tom Ingersoll, Janet Moser, Douglas R. Sommerville, and Harry Salem -- chapter 8. Physiologically based kinetic modeling of inhalation / Harvey J. Clewell III, Jeffry D. Schroeter, and Melvin E. Andersen -- chapter 9. Nanomaterial inhalation exposure from nanotechnology-based consumer products / Yevgen Nazarenko, Paul J. Lioy, and Gediminas Mainelis -- chapter 10. Influence of physicochemical properties on the bioactivity of carbon nanotubes/nanofibers and metal oxide nanoparticles / Dale W. Porter and Vincent Castranova -- chapter 11. Inhalation toxicology of riot control agents / Harry Salem, Michael Feasel, and Bryan Ballantyne -- chapter 12. Incapacitating agents / Joseph L. Corriveau and Michael Feasel -- chapter 13. Exposure to ammonia / Finis Cavender and Glenn Milner -- chapter 14. Serpentine and amphibole asbestos / David M. Bernstein -- chapter 15. Pulmonary primary cells cocultured in a novel cell culture system, the integrated discrete multiple cell-type coculture system (IdMOC) : pulmonary cytotoxicity of eight cigarette smoke condensates and nicotine / Albert P. Li, Patricia Richter, Stephanie Cole, Janna Madren- Whalley, Jonathan Oyler, Russell Dorsey, and Harry Salem -- chapter 16. Animal models of chronic obstructive pulmonary disease (COPD) / Steven G. Kelsen -- chapter 17. Toxic inhalation injury : management and medical treatment / Arik Eisenkraft and Avshalom Falk -- Chapter 18. Transcriptomic responses to crystalline silica exposure / Pius Joseph, Christina Umbright, and Rajendran Sellamuthu -- chapter 19. Mechanisms involved in the inhalation toxicity of phosgene / Wenli Li and Juergen Pauluhn -- chapter 20. Chemical warfare agents and nuclear weapons / Terry J. Henderson, Nabil M. Elsayed, and Harry Salem -- chapter 21. Emergency response planning guidelines / Finis Cavender -- ch. 22. Safety assessment of therapeutic agents administered by the respiratory routes / Shayne C. Gad.
  • 2011 Springer
    Ellis, C. Neal.
    Obtaining and using genetic information -- Cancer and genetic counseling -- An ethos of genetic testing -- Hereditary breast cancer syndromes -- Gastrointestinal polyposis syndromes -- Familial colorectal cancer type X -- The familial atypical multiple mole melanoma (FAMMM)-pancreatic carcinoma (PC) syndrome -- Desmoid disease -- Hereditary nonpolyposis colorectal cancer -- Hereditary ovarian cancer and other gynecologic malignancies.
  • 2014 Springer
    De Laey, J. J.; Holder, Graham E.; Puech, Bernard.
    Introduction to Molecular Genetics and Genetic Testing for Retinal Dystrophies -- Electrophysiological Testing -- Dark Adaptation -- Fluorescein Angiography -- Indocyanine Green Angiography -- Fundus Autofluorescence Imaging in Retinal Dystrophies -- Spectral-Domain Optical Coherence Tomography in Hereditary Retinal Dystrophies -- Inherited Stationary Disorders of the Retina -- Retinitis Pigmentosa and Allied Disorders -- Leber Congenital Amaurosis and Early-Onset Retinal Dystrophy -- Retinitis Punctata Albescens -- Usher Syndromes -- Cone and Cone-Rod Dystrophies -- Enhanced S-Cone Syndrome -- Chorioretinopathies: Choroideraemia and Gyrate Atrophy -- Late-Onset Retinal Dystrophy (LORD) -- Stargardt Disease -- The Bestrophinopathies -- Retinal Dystrophies Associated with the PRPH2 Gene -- Alström Syndrome -- Bardet-Biedl Syndrome -- Cohen Syndrome -- Juvenile Neuronal Ceroid Lipofuscinoses (JNCL) -- Adult Refsum Disease (ARD) -- Abetalipoproteinemia -- LCHAD Deficiency -- Jalili Syndrome -- Spinocerebellar Ataxia 7 -- Dominant Cystoid Macular Dystrophy -- Autosomal Dominant Stargardt-Like Macular Dystrophy (ELOVL4) -- Spastic Paraplegia and Retinal Degeneration: Kjellin Syndrome -- Autosomal Dominant Drusen -- Cuticular Drusen -- Extensive Macular Atrophy with Pseudodrusen-Like Appearance -- Congenital Hypotrichosis with Juvenile Macular Dystrophy -- Mitochondrial Retinopathies -- Sorsby Fundus Dystrophy -- Bietti Crystalline Corneoretinal Dystrophy -- Cystinosis -- Primary Oxalosis -- Alport Syndrome -- X-Linked Retinoschisis -- Paramacular Choriocapillaris Atrophy -- Exudative Vitreoretinopathy -- Stickler Syndrome -- Wagner Syndrome -- Incontinentia Pigmenti Type II (IP2) -- Ganglion Cell Diseases -- Pseudoxanthoma Elasticum -- Aicardi Syndrome -- Microcephaly and Chorioretinopathy With or Without Mental Retardation and Lymphedema -- Alagille Syndrome -- Future Therapies for Retinitis Pigmentosa.
  • 2010 Springer
    Hoffmann, Georg F.; Nyhan, William L.; Zschocke, Johannes.
  • 2009 Springer
    Espinos, Carmen; Felipo, Vicente; Palau, Francese.
    Pathology and diagnosis of muscular dystrophies / Carmen Navarro, Susana Teijeira, Beatriz San Millan.-- Standards of care for Duehenne muscular dystrophy: brief treat-NMD recommendations / Thomas Sejerson, Kate Bushby on behalf of the TREAT-EU Network of Excellence.-- Genetics and pahtogenesis of distal muscular dystrophies / Bjarne Udd.-- Phenotype variations in early onset Pompe disease: Diagnosis and treatment results with Myozyme [RTM] / Samuel Ignacio Pascual Pascual.-- Diseases of the human mitochondrial oxidative phosphorylation system / Julio Montoya, Ester Lopez-Gallardo, Maria Dolores Herrero-Martin, Inigo Martinze-Romero, Aurora Gomez-Duran, Daivd Pacheu, Magdalena Garreras, Carme Diez-Sanchez, Manuel J. Lopez-Perez, Eduardo Ruiz-Pesini.-- Mitochondrial diseases: a cross-talk between mitrochondrial and nuclear genomes / Antonella Spinazzola, Massimo Zeviani.-- Mitochondrial disorders due to nuclear OXPHOS gene defects / Cristina Ugalde, Maria Moran, Alberto Blazquez, Joaquin Arenas, Miguel A. Martin.-- Coenzyme Q10 deficiencies in neuromuscular diseases / Rafael Artuch, Leonardo Salviati, Sandra Jackson, Michio Hirano, Placido Navas.-- The role of mitochondrial network dynamics in the pathogenesis of Charcot-Marie-Tooth disease / Francese Palau, Anna Estela, David Pla-Martin, Maribel Sanchez-Piris.-- Pathogenesis and treatment of mitochondrial disorders / Salvatore DiMauro, Michio Hirano.-- Biology of peripheral inherited neuropathies: Schwann cell axonal interactions / Michael E. Shy.-- Phenotype and clinical evolution of Charcot-Marie-Tooth disease type 1A duplication / Jose Berciano, Antonio Garcia, Elena Gallardo, Cesar Ramon, Onofre Combarros.-- Genotypes & sensory pheotypes in 2 new X-linked neuropathies (CMTX3 and dSMAX) and dominant CMT/HMN overlap syndromes.-- Natural history and treatment of peripheral inherited neuropathies / Davide Pareyson, Chiara Marchesi.-- Spinal muscular atrophy during human development: where are the early pathogenic findings / Eduardo Tizzano.-- Spinal muscular atrophy / Jeremie Vitte, Ruben Attali, Nasim Warwar, Irena Gurt, Judith Melki.-- Friedreich ataxia: an update on animal models, frataxin function and therapies / Pilar Gonzalez-Cabo, Jose Vicente Llorens, Francesc Palau, Maria Dolores Molto.-- Genetics and pathogenesis of inherited ataxias and spastic paraplegias / Carmen Espinos, Francesc Palau.
    Also available: Print – 2009
  • 2007
    Almstead, Laura L.
    PrintStatus: Not Checked OutLane Catalog Record
  • 2011
    Wei, Kevin Shao-Ang; Chang, Ching-Pin; Giaccia, Amato J.; Kim, Seung K.; Kuo, Calvin Jay.
    1. VEGF inhibition increases hematocrit by hepatic Hif-2[Alpha]-dependent erythrocytosis and Hif-2[Alpha]--independent plasma volume contraction. Vascular Endothelial Growth Factor (VEGF) is an essential regulator of angiogenesis whose pharmacological inhibition represents a promising cancer therapeutic modality. We have previously reported that high-grade inhibition of VEGF by adenoviral expression of soluble VEGF receptor (VEGFR) ectodomains and recombinant VEGF Trap protein induce hepatic Epo-dependent erythrocytosis and polycythemia. Here, we demonstrate that VEGF inhibition induces erythrocytosis in a hepatic Hif-2[Alpha]-dependent manner. Conditional inactivation of hepatic Hif-2[Alpha] in Hif2[Alpha] flox/flox mice by either adenovirus Cre injection or albumin-Cre genetic cross suppressed VEGF inhibition-induced hepatic Epo production and blunted hematocrit elevation. Interestingly, a modest rise in hematocrit (5-10%) persisted in VEGF inhibitor-treated Hif-2[Alpha] liver knockout mice despite the absence of hepatic Epo elevation or reticulocytosis. Analysis of red blood cell mass and plasma volume indicate that, in addition to erythrocytosis, VEGF inhibition significantly reduces blood plasma volume (PV) (10-30% decrease) in a EPO- and Hif-2[Alpha]-independent manner. Thus, VEGF inhibition-induced hematocrit elevation in mice is attributable to both hepatic Hif-2[Alpha]-dependent erythrocytosis and Hif-2[Alpha] --independent plasma volume contraction, with accompanying implications for human patients exhibiting elevated haemoglobin levels in response to pharmacologic VEGF inhibition. 2. VEGF Inhibitors Enhance Hepatic insulin Signaling and Ameliorates Diabetes through Activation of Hepatic HIF-2[Alpha]. In the United States, over 18 million people have diabetes and approximately 90% of these cases are the type 2 form of the disease. The central pathophysiologic defect of T2DM is insulin resistance, where tissues such as muscle, fat and liver exhibit reduced responsiveness to insulin, despite normal to elevated levels of production of the hormone. During our studies on the role of vascular endothelial growth factor (VEGF) in erythropoeisis, we made a surprising observation that VEGF inhibition reduces blood glucose in normal lean mice and significantly corrects hyperglycemia in diabetic and insulin-resistant db/db mice. Metabolic profiling of VEGF inhibitor-treated mice revealed enhanced insulin sensitivity at the liver but not at the periphery. In the liver of these mice, expression of insulin receptor substrate-2 (IRS-2) was elevated, accompanied by enhanced Akt activation and suppression of gluconeogenic genes. Hepatic insulin sensitization by VEGF inhibitors requires hypoxia-inducible factor 2-alpha (Hif-2[Alpha]) as genetic deletion of hepatic Hif-2[Alpha] abrogated insulin sensitization and normalizes blood glucose in VEGF inhbitor-treated mice. Conversely, overexpression of a constitutively active allele of Hif-2[Alpha] in liver hepatocytes reduces blood glucose and activates hepatic insulin signaling in vitro and in vivo. Analysis of the human Irs-2 sequence revealed the presence of several potential Hypoxia-Responsive-Elements (HREs) within its 5' promoter. Using a Irs-2 promoter reporter construct, we found that overexpression of Hif-2[Alpha] or addition of a hypoxia-mimetic drug deferoxamine (DFO) resulted in increased Irs-2 transcription. These data suggest Irs-2 is a hypoxia-inducible gene. In this study, we show that VEGF inhibitors improve hepatic insulin action through activation of hepatic HIF-2[Alpha]. Our results suggest Hif-2[Alpha] positively regulates insulin signaling by promoting Irs-2 expression. These data suggest a previously unsuspected link between hypoxia and insulin signaling in the liver and indicate VEGF inhibitors may be useful for the treatment of diabetes.
  • 2007 CRCnetBASE
    Smith, Paul J.; Yue, Eddy W.
  • 2005 Springer
    Alexander, Denis; Cohen, Patricia T. W.; Pinna, Lorenzo A.
  • 2011 Springer
    Bardo, Michael T.; Fishbein, Diana H.; Milich, Richard.
    Part I: Introduction -- Part II: Neurobehavioral approaches for understanding inhibitory control -- Part III: Translating research on inhibitory control to at-risk populations -- PartIV: Translating research on inhibitory control to prevention interventions -- PartV: Conclusion.
  • 2013
    Liang, Liang; Deisseroth, Karl; Luo, Liqun; Schnitzer, Mark Jacob.
    Inhibition occurs throughout the nervous system and impacts diverse neuronal processes. In this dissertation, I focus on an inhibitory circuit motif in the Drosophila olfactory system, parallel inhibition, which differs from the classical feed-forward or feedback inhibition. The Drosophila excitatory and GABAergic inhibitory projection neurons (ePNs and iPNs) each receive input from antennal lobe glomeruli and send parallel output to the lateral horn, a higher-order brain center implicated in regulating innate olfactory behavior. By incorporating in vivo two-photon calcium imaging, advanced fly genetics and optogenetic methods to manipulate and record neuronal activity, we find that iPNs selectively suppress food-related odorant responses but spare signals from pheromone channel stimulation when using specific lateral horn neurons as an olfactory readout. Co-applying food odorant does not affect pheromone signal transmission, suggesting that the differential effects likely result from connection specificity of iPNs, rather than a generalized inhibitory tone. Calcium responses in the ePN axon terminals show no detectable suppression by iPNs, arguing against presynaptic inhibition as a primary mechanism. The parallel inhibition motif may provide specificity in inhibition to funnel specific olfactory information, such as food and pheromone, into distinct downstream circuits.
  • 2008 Springer
    Darlison, Mark G.
    Also available: Print – 2008
  • 2011 Springer
    Maffei, Arianna; Woodin, Melanie A.
    pt. 1. Refinement -- pt. 2. Addiction -- pt. 3. Pain and injury -- pt. 4. Learning and memory.
  • 2012 Wiley
    Garner, Michelle; Wood, Ian.
    Initial assessment of the acute medical patient / Judith Morgan, Ian Wood -- Vulnerable adults / Louise Nelson ... [et al.] -- Sudden death / Sue Read, Jane Jervis -- Cardiac arrest / Carole Donaldson -- Shock / Judith Morgan, Ian Wood -- Altered consciousness / Ian Wood, Carole Donaldson -- Shortness of breath / Michelle Garner, Susan Hope, Ian Wood -- Chest pain / Michelle Garner -- Abdominal pain and upper gastrointestinal bleeding / Toni Jordan, Ruth Harris, Terry Wardle -- Extremity pain and swelling / Ian Wood.
  • 2011 ScienceDirect
    Silverstein, Charles.
    1. Introduction / Charles Silverstein -- 2. Scott's Interview (transcript) / Charles Silverstein -- 3. The initial psychotherapy interview / Charles Silverstein -- 4. Variations on gender and orientation in Scott's first interview / Margaret Nichols -- 5. Institutional aspects of the initial interview / Ronald E. Hellman -- 6. Death and bereavement / Michael C. Singer -- 7. An attachment perspective on the first interview (accelerated experiential dynamic psychotherapy) / Gil Tunnell -- 8. Understanding self-report of sexual abuse in an initial clinical interview / John C. Gonsiorek -- 9. Sex, drugs, and HIV (clinical issues and assessment strategies) / Peter S. Theodore -- 10. Motivational interviewing for health behavior problems / Donald Bux -- 11. Cognitive-behavioral therapy / DeMond M. Grant and LaRicka R. Wingate -- 12. Family systems (the relational contexts of individual symptoms) / Corinne Datchi-Phillips -- 13. Listening as a psychoanalyst / Ralph Roughton -- 14. Psychodrama (in searach of meaning through action) / Jacob Gershoni -- 15. Gay-affirmative psychotheraphy in real time (a first interview) / Armand R. Cerbone.
  • ScienceDirect
    Corbin, Jackie D.; Johnson, Roger A.
    Also available: Print – 1988
  • 2005 CRCnetBASE
    Burgess, Diane J.
  • 2006 Springer
    De Maio, Mauricio; Rzany, Berthold.
  • 2011 Springer
    Stitik, Todd P.
    Basic principles of joint and soft tissue injection procedures -- Pharmacotherapy of joint and soft tissue injections -- Viscosupplementation -- Low back pain: considerations of when to refer patients for interventional spine procedures -- Administrative aspects of office-based injection procedures -- The shoulder -- The elbow -- The wrist -- The hand -- The hip -- The knee and its region -- The ankle and the foot.
  • 2007
    Robertson, Leon S.
    PrintStatus: Not Checked OutLane Catalog Record
    Injury and the role of epidemiology -- Energy characteristics and control strategies -- Research objectives and usable data -- Injury severity -- Injury statistics -- National injury surveillance -- Local injury surveillance -- The use and abuse of causal analysis -- Research designs and data analysis -- Human factors -- Evaluation of programs to change human factors voluntarily -- Evaluation of laws and regulations directed at individual behavior -- Evaluation of agent, vehicle and environmental modifications -- Evaluation of post-injury treatment and rehabilitation -- Injury epidemiology and economics -- Summation of principles.
  • 2016 Springer
    Caine, Dennis John; Purcell, Laura Kathleen.
    Part I: Introduction -- The Exceptionality of the Young Athlete -- Part II: Epidemiology of Injury in Pediatric and Adolescent Sports -- Emergency Department Studies -- Epidemiology of Injury in Community Club and Youth Sport Organizations -- Epidemiology of Injury in High School Sports -- Epidemiology of Pediatric and Adolescent Injury in Adventure and Extreme Sports -- Epidemiology of Injury in Elite Youth Sports -- Part III: Overview of Common Injuries -- Overuse Injuries of the Extremities in Pediatric and Adolescent Sports -- Acute Lower Extremity Injuries in Pediatric and Adolescent Sports -- Acute Upper Extremity Injuries in Pediatric and Adolescent Sports -- Back Pain in the Young Athlete -- Part IV: Potentially Serious Injuries and Outcomes -- Concussion in Young Athletes -- Acute Catastrophic Injuries in High School Sports -- Psychological Injury in Pediatric and Adolescent Sports -- Part V: Injury Causation and Prevention -- Risk Factors for Injury in Pediatric and Adolescent Sports -- Injury Prevention in Youth Sports -- Part VI: Future Research in Pediatric and Adolescent Sports -- Injury Research in Pediatric and Adolescent Sports.
  • 2012 Springer
    Baker, Susan P.; Li, Guohua.
  • 2012
    Phillips, Lori Katherine; Andreasson, Katrin; Jones, Patricia; Martinez, Olivia; Palmer, Theo D.; Wyss-Coray, Tony.
    Stem cells and their derivatives, engineered in vitro prior to transplantation or patterned endogenously by the environment following transplant, are hailed for their promise in treating numerous diseases, from heart disease to diabetes and arthritis. However, one substantial barrier to the success of such treatments is the effect of the immunological response on survival and function of the cells. To this end, the transplantation of neural progenitor cells (NPCs) into the healthy brain provides one of the most favorable situations for graft survival, since the central nervous system is an immune privileged site and NPC are immune privileged cells. Herein, we address whether major histocompatibility complex (MHC) mismatch results in the rejection of NPC grafts placed in the murine hippocampus and investigate which immune effectors affect graft outcome. These transplantation studies reveal that while some allogeneic cells survive, MHC incompatibility strongly inhibits the differentiation and retention of graft-derived as well as endogenously produced new neurons. We also demonstrate that inhibiting innate immune activation with non-steroidal anti-inflammatory drugs decreases observed microglial activation and restores allogeneic neuron production and retention to levels seen in syngeneic grafts. Additionally, we show that MHC and activating ligand expression profiles on NPC facilitates recognition by Natural Killer (NK) cells. We utilize animals deficient for critical innate and adaptive immune receptors to establish that both NK cells and T cells influence graft survival and differentiation. Finally, we evaluate how MHC expression intrinsically influences NPC arborization in vitro. Intriguingly, MHC deficiency results in longer and more extensively branched processes. Taken together, our data suggest that MHC expression on grafted NPC facilitates NPC interaction with multiple other cell types, and consequently cannot be ignored when considering NPC transplantation clinically. Indeed, clinical application of NPC will undoubtedly place these cells into injured or diseased brains, where immune barriers may be more substantial. However, these data provide a starting point for evaluation of appropriate immune modulation strategies for such transplants.
  • 2008 Springer
    Yefenof, Eitan.
  • 2013
    Goh, Yun Pei Sharon; Chawla, Ajay; Galli, Stephen J.; Martinez, Olivia; Steinman, Lawrence.
    Eosinophil-derived IL-4 stimulates hepatocyte proliferation to promote liver regeneration Abstract It has been proposed that allergic immune responses, like those mediated by type 2 immunity, evolved to protect the host from damage caused by environmental challenges, including toxins, xenobiotics, and helminth infections (1, 2). Despite some support for this hypothesis (3, 4), the underlying mechanisms by which type 2 innate responses orchestrate the regeneration of injured tissues remain largely unknown. Here, we demonstrate a requirement for type 2 innate immunity in regeneration of liver after partial hepatectomy and toxin-mediated injury. Injury to liver results in rapid recruitment of eosinophils, which secrete IL-4 to promote the proliferation of quiescent hepatocytes. Surprisingly, signaling via the IL-4R[alpha] in macrophages, which have been implicated in tissue repair (3-5), is dispensable for hepatocyte proliferation and liver regrowth after injury. Instead, IL-4 exerts its mitogenic actions by directly activating IL-4R[alpha] in hepatocytes. Our findings have thus uncovered an unexpected mechanism by which allergic type 2 innate immunity stimulates hepatocyte proliferation to promote liver regeneration.
  • 2012 Springer
    Wang, Rong-fu.
    "There has been major growth in understanding innate immune signaling, inflammation, immune suppression and cancer immunotherapy. Innate immune regulation and cancer immunotherapy highlights emerging research about the underlying mechanisms of innate immunity and signaling regulation, inflammation and immune suppression that promote or inhibit cancer development and progression, and offers novel ideas and strategies to develop therapeutic cancer drugs or cell therapy by manipulating or blocking these negative signaling pathways and generating potent antitumor immunity. Recent studies have identified key innate immune receptors or sensors, novel signaling molecules and immune regulatory molecules that control immune responses, inflammation and immune suppression in cancer and other diseases. Major progresses in understanding of tumor antigens, immune suppressive molecules and cell population and novel vaccine strategies bring therapeutic cancer vaccines and drugs in realty. With chapters written by internationally recognized contributors, this book provides essential introduction and guide for immunologists, basic, translational and clinical cancer researchers."--Publisher's website.
  • 2013
    Nguyen, Khoa Dinh; Chawla, Ajay; Engleman, Edgar G.; Mellins, Elizabeth; Steinman, Lawrence.
    Monophagocytes are a frontline defense against anything that should not be present in the body. Being highly mobile, they infiltrate almost every tissue to consume and dispose of material that might be damaging. To fight pathogens, monocytes and macrophages are transformed into pro-inflammatory machines that secrete catecholamines. However, monocytes and macrophages also exist in alternatively activated, anti-inflammatory forms that have a wide range of physiological roles. Unlike classically activated cells, which exhibit high pro-inflammatory potential, alternatively activated monocytes and macrophages (which are promoted by the TH2-type cytokines IL-4 and IL-13) are less pro-inflammatory and have distinct secretory and functional capacities. The inherent functional plasticity as well as the omnipresence of monocytes and macrophages in all tissues enables them to sense environmental changes. My dissertation will highlight two physiological settings in which, monocytes and macrophages, act as the sensors of perturbations in the environment to activate distinct physiological programs. The first part of my dissertation will discuss the role of adipose tissue alternatively activated macrophages in sensing changes in environmental temperature and its subsequent involvement in the maintenance of body temperature. The second part of my dissertation will provide evidences to show that inflammatory monocytes can sense change in the daily light dark cycle via their interaction with the circadian clock system to generate diurnal oscillation in monocyte-mediated inflammation.
  • 2008 Springer Protocols
    Ewbank, Jonathan; Vivier, E.
    ENU mutagenesis in mice / Philippe Georgel ... [et al.] -- Innate immunity genes as candidate genes : searching for relevant natural polymorphisms in databases and assessing family-based association of polymorphisms with human diseases / Pascal Rihet -- KIR locus polymorphisms : genotyping and disease association analysis / Maureen P. Martin and Mary Carrington -- Experimental model for the study of the human immune system : production and monitoring of "human immune system" Rag2-/[gamma]c-/- mice / Nicolas Legrand, Kees Weijer, and Hergen Spits -- Bacterial artificial chromosome transgenesis through pronuclear injection of fertilized mouse oocytes / Kristina Vintersten ... [et al.] -- Bioluminescence imaging to evaluate infections and host response in vivo / Pamela Reilly Contag -- Intravital two-photon imaging of natural killer cells and dendritic cells in lymph nodes / Susanna Celli, Béatrice Breart, and Philippe Bousso -- Dissection of the antiviral NK cell response by MCMV mutants / Stipan Jonjic ... [et al.] -- Analyzing antibody-Fc-receptor interactions / Falk Nimmerjahn and Jeffrey V. Ravetch -- The isolation and identification of murine dendritic cell populations from lymphoid tissues and their production in culture / David Vremec and Ken Shortman -- Analysis of individual natural killer cell responses / Wayne M. Yokoyama and Sungjin Kim -- Isolation and analysis of human natural killer cell subsets / Guido Ferlazzo -- Innate immune function of eosinophils : from antiparasite to antitumor cells / Fanny Legrand ... [et al.] -- Ex vivo and in vitro primary mast cells / Michel Arock ... [et al.] -- Murine macrophages : a technical approach / Luisa Martinez-Pomares and Siamon Gordon -- Clinical analysis of dendritic cell subsets : the dendritogram / Anne Hosmalin, Miriam Lichtner, and Stéphanie Louis -- Clinical analysis of human natural killer cells / Pascale André and Nicolas Anfossi -- Lentiviral transduction of immune cells / Louise Swainson ... [et al.] -- Axenic mouse model / Antoine Giraud -- In vivo analysis of zebrafish innate immunity / Jean-Pierre Levraud ... [et al.] -- Reverse genetics analysis of antiparasitic responses in the malaria vector, Anopheles gambiae / Stephanie A. Blandin and Elena A. Levashina -- Drosophila immunity : methods for monitoring the activity of toll and Imd signaling pathways / Yves Romeo and Bruno Lemaitre -- Investigating the involvement of host factors involved in intracellular pathogen infection by RNAi in Drosophila cells / Hervé Agaisse -- Models of Caenorhabditis elegans infection by bacterial and fungal pathogens / Jennifer R. Powell and Frederick M. Ausubel -- Genetic analysis of Caenorhabditis elegans innate immunity / Michael Shapira and Man-Wah Tan -- Measuring cell-wall-based defenses and their effect on bacterial growth in Arabidopsis / Min Gab Kim and David Mackey.
  • 2013 Karger
    Hartmann, Gunther; Wagner, H.
    Microbiota's influence on immunity / Honda, K. ... [et al.] -- Inflammasomes and mucosal immune response / Elinav, E., Henao-Mejia, J., Flavell, R.A. -- Microbial endocrinology : an evolution-based shared mechanism determining microbiota's influence on health and disease / Lyte, M. -- Standing guard : innate lymphoid cells promote immunity and tissue homeostasis at barrier surface / Monticelli, L.A., Artis, D. -- miRNAs that shape the innate immune system : regulation through toll-like receptor signaling / Curtis, A.M., O'Neill, L.A. -- Type 2 diabetes and islet inflammation / Donath, M.Y. -- The innate immune system in Alzheimer's disease / Becker, H., Halle, A. -- Role of inflammasomes in obesity / Dixit, V.D. -- Gut-brain communication in the regulation of system metabolism / Miller, T.D., Pfliger, P.T., and Tschip, M.H. -- Metabolism and innate immunity : FOXO regulation of antimicrobial peptides in drosophila / Loch, G. ... [et al.] -- Dendritics cells orchestrate innate immunity agains bacterial kidney infection / Tittel, A.P. ... [et al.].
  • 2007
    Wanner, Adam.
  • 2008 Springer
    Heine, Holger.
    Evolution of resistance genes in plants / Shunyuan Xiao, Wenming Wang, Xiaohua Yang -- The path less explored: innate immune reactions in Cnidarians / Thomas C. G. Bosch -- Bug versus bug : humoral immune responses in Drosophila melanogaster / Deniz Ertürk-Hasdemir ... [et al.] -- Cellular immune responses in Drosophila melanogaster / Adrienne Ivory, Katherine Randle, Louisa Wu -- Immune reactions in the vertebrates' closest relatives, the urochordates / Konstantin Khalturin, Ulrich Kürn, Thomas C. G. Bosch -- Innate immune system of the zebrafish, Danio rerio / Con Sullivan, Carol H. Kim -- Toll-like receptors in the mammalian innate immune system / Andrei E. Medvedev, Stefanie N. Vogel -- NLRs : a cytosolic armory of microbial sensors linked to human diseases / Mathias Chamaillard -- Antimicrobial peptides as first-line effector molecules of the human innate immune system / Regine Gläser, Jürgen Harder, Jens-Michael Schröder -- The complement system in innate immunity / K. R. Mayilyan ... [et al.].
  • 2013 Springer
    Gidday, Jeffrey M.; Perez-Pinzon, Miguel A.; Zhang, J. H.
    Cerebral ischemia from cardiac arrest, stroke, and subarachnoid and intracerebral hemorrhage, together with trauma, epilepsy, and other CNS pathologies, continue to impose immense burdens of morbidity and mortality the world over. Despite many decades of research aimed at understanding the genetic and molecular basis of these pathologies, therapeutics developed on the basis of blocking 'known' injury mechanisms can actually claim few clinical successes. The field of CNS "preconditioning" was born from the preclinical finding more than 20 years ago that intentional activation of innate, cytoprotective factors could provide robust protection, or "tolerance" against cerebral ischemic injury. Herein, up-to-date summaries on all aspects of preconditioning for CNS disease, including the emerging topics of postconditioning and remote pre- and post-conditioning, are provided by the leading scientists in the field. The translational potential of both preclinical and clinical advances is underscored throughout, with the hope of accelerating the bench-to-bedside success of endogenous cytoprotection as a therapeutic strategy. Jeffrey M. Gidday PhD, Associate Professor of Neurosurgery at Washington University School of Medicine, has been working in the field of CNS preconditioning for 18 years, and has numerous publications on preconditioning-induced protection in the setting of several different cerebral and retinal pathologies. Miguel A. Perez-Pinzon PhD is Professor of Neurology/Neuroscience, Vice-Chair for Basic Science of Neurology at the University of Miami Miller School of Medicine. He began studies of ischemic preconditioning in 1995 and for many years prior to that worked in the field of anoxia tolerance, publishing close to 50 peer-reviewed articles and many book chapters on these topics. John H. Zhang MD PhD is Professor of Neurosurgery, Anesthesiology, and Physiology, and Vice-Chair of the Basic Science Department at the Loma Linda University School of Medicine. His research interests include stroke and medical gases, and he has published papers related to pre-, post- and remote-conditioning in subarachnoid hemorrhage, focal cerebral ischemia, and neonatal brain injury.
  • 2006 Springer
    Neuhuber, Winfried L.
  • 2015 Springer
    Ahn, Roy; Burke, Thomas F.; McGahan, Anita M.
    Innovations to address specific populations and health -- Maternal health innovations and urbanization / Melody Eckardt, Hannah L. Harp, Roy Ahn, Genevieve Purcell, Emily de Redon, Rosemary Hines, and Thomas F. Burke -- Innovations in low- and middle-income countries for newborn and child health / Brett D. Nelson, Lisa B. Collins, and Edward W.J. Pritchard -- Addressing micronutrient malnutrition in urban settings / Laura A. Rowe and David M. Dodson -- Innovations to address specific urbanization-related threats to health -- Innovations in antihuman trafficking efforts : implications for urbanization and health / Roy Ahn, Genevieve Purcell, Anita M. McGahan, Hanni Stoklosa, Thomas F. Burke, Kathryn Conn, Hannah L. Harp, Emily de Redon, Griffin Flannery, and Wendy Macias Konstantopoulos -- Securing cities : innovations for the prevention of civic violence / Horacio R. Trujillo, Elena Siegel, Malcolm Clayton, Gabe Shapiro, and David Elam -- Disaster preparedness and response innovations : implications for urbanization and health / Laura Janneck and Paul Biddinger -- Innovations to address global drug counterfeiting : implications for urbanization and health / Kendra Amico, Emily Aaronson, and Howard Zucker -- Community noise, urbanization and global health : problems and solutions / Charles M. Salter, Roy Ahn, Faiza Yasin, Rosemary Hines, Laurence Kornfield, Ethan C. Salter, and Thomas F. Burke -- Modeling vulnerable urban populations in the global context of a changing climate / Vijay Lulla, Austin Stanforth, Natasha Prudent, Daniel Johnson, and George Luber -- Urbanization and unintentional Injury in low- and middle-income countries / John D. Kraemer -- Frameworks, cases and tools to address urbanization and health through innovation -- The Millennium Cities Initiative : an experiment in integrated urban development / Susan M. Blaustein -- Diagnostic innovations in developing urban settings / Patrick Beattie, Matthew Stewart, and Charles Mace -- Innovations in global health professional education : implications for urbanization / Leana S. Wen -- The case for comprehensive, integrated, and standardized measures of health in cities / Patricia L. McCarney and Anita M. McGahan.
  • NAP
    Hanna, Kathi E.
  • 2012 Springer
    Bonavina, Luigi.
    Assessment of Surgical Innovation / Luigi Bonavina -- Clinical Impact of High-Resolution Manometry and Impedance-pH Monitoring / Marion Hädrich, Radu Tutuian -- Magnetic Augmentation of the Lower Esophageal Sphincter: Changing the Treatment Paradigm in Patients with Gastroesophageal Reflux Disease / Luigi Bonavina, Greta Saino, Davide Bona -- Transoral Esophageal Myotomy for Achalasia / Karl-Hermann Fuchs, Wolfram Breithaupt, Gábor Varga -- Radiofrequency Ablation and Antireflux Management for Non-dysplastic Barrett's Esophagus / Stephanie Fischer See, Sebastian F. Schoppmann -- Esophageal Preservation in Barrett's Esophagus with High-Grade Dysplasia and Mucosal Adenocarcinoma / Thomas J. Watson, Jeffrey H. Peters -- Cost-Effectiveness of Radiofrequency Ablation for Barrett's Esophagus / Francesca Rancati, Emanuele Meroni -- Vagal-Sparing Esophagectomy / Steven R. DeMeester -- Thoracoscopic Esophagectomy / Miguel A. Cuesta, Donald L. van der Peet -- Limited Versus Extended Lymphadenectomy / S. Michael Griffin, Shajahan Wahed -- Definitive Chemoradiation Therapy / Joel Shapiro M.D., J. Jan B. van Lanschot -- The Art and Science of Esophageal Anastomosis / Simon Law -- Rationale and Outcomes of the Kaizen Method Applied to Esophagectomy / Mark D. Iannettoni -- Perioperative Nutrition / Marco Braga -- Quality Assessment, Education and Training in Esophageal Surgery / Arnulf H. Hölscher, Ulrich K. Fetzner -- The Future of Esophageal Surgery / Tom R. DeMeester.
  • 2007
    Eaton, Margaret L.; Kennedy, Donald.
    PrintStatus: Not Checked OutLane Catalog Record
    Introduction : the need to ask questions about innovation -- Distinguishing innovative medical practice from research -- The modern history of human research ethics -- Innovation in the off-label use of drugs -- Innovative surgery -- Innovation in assisted reproduction -- Innovation in neuroimaging -- Questions, issues, and recommendations going forward -- Conclusion : final thoughts on the landscape of innovation.
  • 2012 Springer
    Baschieri, Selene.
    Prevention of infectious diseases by vaccination is one of the most significant achievements of modern medicine. During the 20th century, the average human life span in the developed world was about 70 years and it is expected to increase, with a significant portion of this increase directly attributed to vaccination. Since the first empiric vaccination trials, knowledge and technology have enormously evolved and new vaccination strategies are emerging on the market. Indeed, in spite of the great success, conventional vaccination strategies sometimes may result ineffective and, above all, may
  • 2013 Springer
    Berkowitz, Lyle; McCarthy, Chris.
    The healing edge / Lyle Berkowitz and Chris McCarthy -- Mad for method / Chris McCarthy and Christi Dining Zuber -- section 1. You have an EHR: now what?!!?!. The inflection navigator / Lyle Berkowitz -- Making "right" easier / Peter Basch -- Prevention every time / James L. Holly -- Logic rules! / John W. Trudel and Lloyd D. Fisher -- "All or none" bundle philosophy / Thomas R. Graf -- Automatically getting better / David C. Stockwell and Brian R. Jacobs -- section 2. Meet you at 01100101. The connected patient / Jonathan S. Wald -- The virtual consult / Erin DeMarce Leff ... [et al.] -- TeleVisit keeps IT local / Ajay Sood ... [et al.] -- Mommy monitor / Steve Huffman and April R. Daugherty -- Every language now / David D. O'Neill, Susan Anthony, and Margaret Laws -- Rise of the ePharmacists / Mark S. Gagnon and Janell Moerer -- section 3. On the edge of edge. The smartest room / Tamra E. Minnier and David T. Sharbaugh -- One EMR to go please / Steve Flammini and James W. Noga -- Real-time, right care / Debra J. Hurd and Brian D. Patty -- Dashboards 2.0 / George Reynolds -- The patient voice amplified / Valerie M. Sue and Karen Tsang -- The gaming edge / Alex Tam, Vivian Distler, and Bradley Kreit.
  • 2001 ScienceDirect
    Wagner, Eric F.; Waldron, Holly.
  • 2009 Springer
    Şener, Bilge.
  • 2014 Springer
    Rhodes, Scott D.
    HIV continues to be a profound challenge facing communities nationally and internationally. Until a vaccine or a cure is found, prevention remains a most crucial line of defense. However, the successes made to reduce exposure and transmission have not benefited all communities equally. HIV continues to affect vulnerable communities, and HIV-related health disparities are growing. The work documented in Innovations in HIV Prevention Research and Practice through Community Engagement spotlights the effectiveness of community involvement to reduce HIV infections in the United States. This timely resource introduces the concepts of community engagement, partnership, and community-based participatory research (CBPR). Contributors provide detailed examples of these concepts in which diverse research partners blend their unique insights and skills to arrive at an authentic understanding of phenomena and inform the translation of best practices and processes to enhance equity in HIV prevention and treatment. Equitable interactive collaboration is central to these efforts, in which community members and representatives from organizations, the scientific and medical sectors, and other relevant agencies nurture long-term health improvement through sustained teamwork. Challenges and barriers to effective engagement are identified, as are characteristics of successful partnerships. Included in the book: Details of a multigenerational HIV prevention intervention in a rural southeastern community. The challenges and successes of developing, implementing, and evaluating an intervention for higher-risk predominately heterosexual black men in college. The history of gay community involvement in HIV prevention and its contributions to the theory and current practice of engagement. Next steps in the integration of HIV-related policy change and research. Community engagement within American Indian communities. Keys to sustaining a CBPR partnership to prevent HIV within ethnic, sexual, and gender minority communities. Innovations in HIV Prevention Research and Practice through Community Engagement offers researchers and practitioners in public health, community health, and medicine guidance on community engagement that is both inspiring and realistic. 'Community engagement and knowledge continue to be essential to prevent HIV infections. This book is a compilation of the state-of-the-science of engagement and delves deeper into the meaning and utilization of community-based participatory research, with implications that reach beyond the HIV epidemic to public health and medicine in general.' - Laura C. Leviton, PhD, Senior Advisor for Evaluation, Robert Wood Johnson Foundation, Princeton, NJ
  • 2008 Springer
    Eisenmann-Klein, M.; Neuhann-Lorenz, C.
  • 2005 Springer
    Baptiste, Sue; Solomon, Patricia.
  • 2008 Springer
    Berstein, Lev M.; Santen, Richard J.
    Also available: Print – 2008
  • 2006 IARC
    Also available: Print – 2006
  • 2013 WHO
    Sheffer, Marla.
    Also available: Print – 2013
  • 2009
    Santonen, Tiina.
  • 2005 CRCnetBASE
    Sangeeta, D.; LaGraff, John R.
  • ScienceDirect
    LeGall, Jean; Peck, Harry D.
    Also available: Print – 1994
  • 2006 Springer
    Lecoq, Paul.
  • 2009 Springer Protocols
    Barker, Christopher J.
    The role of inositol and the principles of labelling, extraction, and analysis of inositides in mammalian cells / Christopher J. Barker and Per-Olof Berggren -- HPLC separation of inositol polyphosphates / Christopher J. Barker, Christopher Illies, and Per-Olof Berggren -- Molecular manipulation and analysis of inositol phosphate and pyrophosphate levels in mammalian cells / James C. Otto and John D. York -- A femtomole-sensitivity mass assay for inositol hexakisphosphate / Andrew J. Letcher, Michael J. Schell, and Robin F. Irvine -- Synthesis of InsP₇ by the inositol hexakisphosphate kinase 1 (IP6K1) / Cristina Azevedo ... [et al.] -- Protein pyrophosphorylation by diphosphoinositol pentakisphosphate (InsP₇) / J. Kent Werner Jr., Traci Speed, and Rashna Bhandari -- Synthesis and nonradioactive micro-analysis of diphosphoinositol phosphates by HPLC with postcolumn complexometry / Hongying Lin, Karsten Lindner, and Georg W. Mayr -- Diphosphosinositol polyphosphates and energy metabolism : assay for ATP/ADP ratio / Andreas Nagel ... [et al.] -- Isolation of inositol 1,4,5-triphosphate receptor-associating proteins and selective knockdown using RNA interference / Akihiro Mizutani ... [et al.] -- Phosphoinositide-specific phospholipase C [beta]1 signal transduction in the nucleus / Roberta Fiume ... [et al.] -- Methods to assess changes in the pattern of nuclear phosphoinositides / Nullin Divecha -- Measurement of phosphoinositide 3-kinase products in cultured mammalian cells by HPLC / Frank T. Cooke -- Phosphoinositide analysis by liquid chromatography-mass spectrometry / Trevor R. Pettitt -- Imaging phosphoinositide dynamics in living cells / Anne Wuttke, Olof Idevall-Hagren, and Anders Tengholm.
  • 2003. ScienceDirect
    Kuksis, Arnis.
    Also available: Print – 2003
  • 2012 ClinicalKey
    Insall, John N.; Scott, W. Norman.
    Online and in print, Insall & Scott Surgery of the Knee, edited by W. Norman Scott, MD, and 11 section editors who are experts in their fields, is your complete, multimedia guide to the most effective approaches for diagnosis and management of the full range of knee disorders affecting patients of all ages. From anatomical and biomechanical foundations, to revision total knee replacement, this authoritative reference provides the most up-to-date and complete guidance on cutting-edge surgical procedures, the largest collection of knee videos in one knee textbook. Expanded coverage and rigorous updates-including 40 online-only chapters-keep you current with the latest advances in cartilage repair and regeneration, allograft and autografts, computer robotics in total knee arthroplasty, and other timely topics. This edition is the first book ever endorsed by The Knee Society. Access the full text - including a wealth of detailed intraoperative photographs, a robust video library, additional online-only chapters, a glossary of TKR designs, quarterly updates, and more - at www.expertconsult.com. Get all you need to know about the clinical and basic science aspects of the full range of knee surgeries as well as the latest relevant information, including imaging and biomechanics; soft tissue cartilage; ligament/meniscal repair and reconstructions; partial and total joint replacement; fractures; tumors; and the arthritic knee. Master the nuances of each new technique through step-by-step instructions and beautiful, detailed line drawings, intraoperative photographs, and surgical videos. See exactly how it's done. Watch master surgeons perform Partial and Primary TKR, Revision TKR, Tumor Replacement, Fracture Treatment, and over 160 videos on the expertconsult.com. Find information quickly and easily thanks to a consistent, highly templated, and abundantly illustrated chapter format and streamlined text with many references and chapters appearing online only.
  • v. 1-2, 2006.
    Insall, John N.; Scott, W. Norman.
    PrintStatus: Not Checked OutLane Catalog Record
  • Google Books
    Blandford, George Fielding.
    Also available: Print – 1871.
  • 2010 Springer
    Thany, Steeve Herve.
    Identification of cholinergic synaptic transmission in the insect nervous system / Steeve Hervé Thany, Hélène Tricoire-Leignel, and Bruno Lapied -- The evolution of pentameric ligand-gated ion channels / Joseph A. Dent -- Diversity of insect nicotinic acetylcholine receptor subunits / Andrew K. Jones and David B. Sattelle -- Identification of critical elements determining toxins and insecticide affinity, ligand binding domains, and channel properties / Hélène Tricoire-Leignel and Steeve Hervé Thany -- Electrophysiological studies and pharmacological properties of insect native nicotinic acetylcholine receptors / Steeve Hervé Thany -- Characterisation of insect nicotinic acetylcholine receptors by heterologous expression / Neil S. Millar and Stuart J. Lansdell -- Neonicotinoid insecticides : historical evolution and resistance mechanisms / Steeve Hervé Thany -- Ecotoxicity of neonicotinoid insecticides to bees / Axel Decourtye and James Devillers -- State of the art on insect nicotinic acetylcholine receptor function in learning and memory / Monique Gauthier.
    Also available: Print – 2010
  • 2000- NCBI Bookshelf
    A collection of syntheses of the international scientific literature and recommendations on public health problems, by Inserm's expert advisory groups.
  • 2011 Springer
    Dupuy, Adam J.; Largaespada, David A.
    1. Insertional Mutagenesis: A Powerful Tool in Cancer Research -- 2. Retroviral Insertional Mutagenesis in Mouse Models of Leukemia and Lymphoma -- 3. Gene Discovery by MMTV Mediated Insertional Mutagenesis -- 4. Chicken Models of Retroviral Insertional Mutagenesis -- 5. Sleeping Beauty Models of Cancer -- 6. Insertional Mutagenesis in Hematopoietic Cells: Lessons Learned from Adverse Events in Clinical Gene Therapy Trials -- 7. Bioinformatics of High-Throughput Insertional Mutagenesis -- Index.
  • 2013 CRCnetBASE
    Fleming, Tony.
    1. Introduction -- 2. Self-field theory -- 3. Biological and cosmological evolution -- 4. Biophotons and diffusion in biology -- 5. Cell division and membrane diffusion -- 6. Electromagnetic and acoustic-based therapies.
  • 2014 Springer
    Fay, Richard R.; Koppl, Christine; Manley, Geoffrey A.; Popper, Arthur N.
    The hearing organs of non-mammals, which show quite large and systematic differences to each other and to those of mammals, provide an invaluable basis for comparisons of structure and function. By taking advantage of the vast diversity of possible study organisms provided by the "library" that is biological diversity, it is possible to learn how complex functions are realized in the inner ear through the evolution of specific structural, cellular and molecular configurations. Insights from Comparative Hearing Research brings together some of the most exciting comparative research on hearing and shows how this work has profoundly impacted our understanding of hearing in all vertebrates.
  • 2009
    Brandman, Relly.
    PrintStatus: Not Checked OutLane Catalog Record
  • 2006 Springer
    Christen, Yves; Conn, P. Michael; Kordon, Claude.
  • 2015 Springer Protocols
    García-Fruitós, Elena.
    General introduction : recombinant protein production and purification of insoluble proteins / Neus Ferrer-Miralles ... [et al.] -- Overcoming the solubility problem in E. coli : available approaches for recombinant protein production / Agustín Correa and Pablo Oppezzo -- Optimization of culture parameters and novel strategies to improve protein solubility / Ranjana Arya ... [et al.] -- Cleavable self-aggregating tags (cSAT) for protein expression and purification / Zhanglin Lin ... [et al.] -- Beyond the cytoplasm of Escherichia coli : localizing recombinant proteins where you want them / Jason T. Boock ... [et al.] -- Characterization of amyloid-like properties in bacterial intracellular aggregates / Anna Villar-Pique, Susanna Navarro, and Salvador Ventura -- Co-translational stabilization of insoluble proteins in cell- free expression systems / Lei Kai ... [et al.] -- Functional expression of plant membrane proteins in Lactococcus lactis / Sylvain Boutigny .... [et al.] -- High cell-density expression system : yeast cells in a phalanx efficiently produce a certain range of "Difficult-to-Express" secretory recombinant proteins / Yasuaki Kawarasaki, Takeshi Kurose, and Keisuke Ito -- Insect cells-baculovirus system for the production of difficult to express proteins / Judit Osz-Papai ... [et al.] -- Transient expression in HEK 293 cells : an alternative to E. coli for the production of secreted and intracellular mammalian proteins / Joanne E. Nettleship ... [et al.] -- Recombinant glycoprotein production in human cell lines / Kamilla Swiech ... [et al.] -- Soluble recombinant protein production in Pseudoalteromonas haloplanktis TAC125 / Maria Giuliani ... [et al.] -- Screening methodology for purifying proteins with aggregation problems / Mario Lebendiker, Michal Maes, and Assaf Friedler -- Solubilization and refolding of inclusion body proteins / Anupam Singh, Vaibhav Upadhyay, and Amulya K. Panda -- Bacterial inclusion body purification / Joaquin Seras-Franzoso ... [et al.] -- Characterization of intracellular aggresomes by fluorescent microscopy / Lianwu Fu and Elizabeth Sztul -- Dialysis : a characterization method of aggregation tendency / Mireia Pesarrodona, Ugutz Unzueta, and Esther Vázquez -- Applications of mass spectrometry to the study of protein aggregation / Sílvia Bronsoms and Sebastián A. Trejo -- Insoluble protein assemblies characterized by Fourier transform infrared spectroscopy / Antonino Natalello and Silvia M. Doglia -- Insoluble protein characterization by circular dichroism (CD) spectroscopy and nuclear magnetic resonance (NMR) / Shaveta Goyal ... [et al.] -- Methods for characterization of protein aggregates / Witold Tatkiewicz ... [et al.] -- Predicting the solubility of recombinant proteins in Escherichia coli / Roger G. Harrison and Miguel J. Bagajewicz -- Insoluble protein applications : the use of bacterial inclusion bodies as biocatalysts / Eva Hrabárová , Lucia Achbergerová , and Jozef Nahálka.
  • 2010 Springer
    Carney, Colleen; Edinger, Jack D.
    Insomnia is often undiagnosed, or treated as a symptom of anxiety. This is the first guidebook for clinicians that considers the evaluation and management of insomnia and related sleep disturbances that occur conjointly with the common anxiety disorders.
  • v. 1, 1986.
    McCartor, Robert L.; Tyner, G. S.
    PrintStatus: Not Checked OutLane Catalog Record
    v. 1. Eye of the storm / Robert L. McCartor and George S. Tyner.
  • 2008 ClinicalKey
    O'Connell, Theodore X.
  • 2009 ClinicalKey
    O'Connell, Theodore X.; Dor, Kathleen.
    This book is a portable pocket resource and quick refresher that helps you develop and refine your diagnostic skills. Practical and easy to use, it provides clear workup plans for the most common obstetric and gynecologic conditions, providing you with quick, focused guidance with the flexibility to adapt to each unique patient. Topics are organized alphabetically and cover the signs, symptoms, and abnormal lab readings for each condition. Replace information taken from memory or multiple references with one concise, indispensable book so you can make accurate diagnoses in less time! Covers the most commonly encountered obstetric and gynecologic conditions to provide you with a practical and useful manual for daily practice. Reflects how a patient actually presents by organizing alphabetically by presenting sign, symptom, or lab abnormality. Includes a brief background discussion on each topic, followed by lists of important related materials (such as medications that may contribute to each condition) and laboratory and/or radiographic tests to be ordered. Describes each diagnostic test so you can refresh or familiarize yourself with the purpose of the test. Provides a sound framework for building your workups using detailed treatment algorithms.
  • 2010 ClinicalKey
    O'Connell, Theodore X.
    Instant Workups: Clinical Guide to Pediatrics, by Theodore X. O'Connell, MD, is a portable pocket resource and quick refresher that helps you develop and refine your diagnostic skills. Practical and easy to use, it provides clear workup plans for the most common pediatric conditions, providing you with quick, focused guidance with the flexibility to adapt to each unique patient. Topics are organized alphabetically and cover the signs, symptoms, and abnormal lab readings for each condition. Replace information taken from memory or multiple references with one concise, indispensable book so you can make accurate diagnoses in less time! Covers the most commonly encountered pediatric conditions to provide you with a practical and useful manual for daily practice. Reflects how a patient actually presents with an organization by presenting sign, symptom, or lab abnormality. Includes a brief background discussion on each topic, followed by lists of important related materials (such as medications that may contribute to each condition) and laboratory and/or radiographic tests to be ordered. Describes each diagnostic test so you can refresh or familiarize yourself with the purpose of the test. Provides a sound framework for building a workup with algorithms for each topic.
  • NAP
  • Google Books
    Also available: Print – 1956-
  • 2012 ClinicalKey
    Safran, Marc R.; Stone, David A.; Zachazewski, James E.
  • 1. Getting started -- 2. Instrument control session -- 3. Using interface objects -- 4. Controlling instruments using GPIB -- 5. Controlling instruments using VISA -- 6. Controlling instruments using the serial port -- 7. Controlling instruments using TCP/IP and UDP -- 8. Using device objects -- 9. Using VXIplug&play drivers -- 10. Using IVI drivers -- 11. Using generic instrument drivers -- 12. Saving and loading the session -- 13. Test & measurement tool -- 14. Using the instrument driver editor -- 15. Using the instrument driver testing tool -- 16. Using the Instrument Control Toolbox block library -- A. Vendor driver requirements and limitations.
  • 2006 CRCnetBASE
    Mills, Terry.
    V. 1. Acebutolol -- Dapsone -- v. 2. Dauromycin -- Indigotin Disulfonate -- v. 3. Indole-3-Acetic Acid -- Phendimetrazine -- v. 4. Phenelzine -- Zoxazolamine -- v. 5. Raman spectra data -- Mass spectra of pesticides -- Mass spectra of derivatized drugs -- Gas chromatography/infrared spectra of drugs -- v. 6. Standard KBr infrared spectra and standard NMR solvent spectra -- Supplemental infrared spectra -- Supplemental NMR spectra -- Ultraviolet absorption maxima -- Infrared index -- Mass spectra indices of drugs -- Mass spectra indices of pesticides -- Molecular formula index -- Gas chromatographic data -- Index to specific compounds.
  • 2007
    Brooks Tighe, Shirley M.
    PrintStatus: Not Checked OutLane Catalog Record
    Instrument preparation for surgery -- General Surgery -- Female Reproductive Surgery -- Genitourinary surgery -- Orthopedic surgery -- Eye, ear, nose, and throat surgery -- Oral, maxillary, and facial surgery -- Plastic surgery -- Peripheral vascular, cardiovascular, and thoracic surgery -- pediatric surgery -- Neurosurgery.
  • 2006 Springer
    Mebazaa, Alexandre; Payen, D.
  • 2011 Springer
    Fantus, I. George.
    Insulin and the Physiology of Carbohydrate Metabolism -- Insulin/IGF-1 Signaling Nodes and their Role in Carcinogenesis -- The Mechanisms and Impact of Obesity and Insulin Resistance on Breast Cancer Incidence -- Obesity and Cancer: Epidemiology -- Insulin, Insulin Resistance, and Cancer Associations -- Animal Models of Hyperinsulinemia, Insulin Resistance, and Cancer -- Potential Mechanisms Linking Insulin to Cancer -- Actions of Insulin As a Survival and Growth Factor: Akt, mTOR, and Regulation of Translation -- AMP-Activated Protein Kinase and Cancer Cell Metabolism -- The Role of the IGF Axis in Human Malignancy: Evidence from Epidemiological Studies and Tissue Analysis -- IGF-I and Insulin Receptor Families in Cancer -- Insulin Resistance: Clinical Implications for Cancer Treatment and Prevention.
  • 2007 Springer
    Diamanti-Kandarakis, Evanthia; Nestler, John E.; Panidis, Dimitrios; Pasquali, Renato.
    1. Evaluation for insulin resistance and comorbidities related to insulin resistance in polycystic ovary syndrome / Ricardo Azziz -- 2. Fat distribution and adipose products in polycystic ovary syndrome / Enrico Carmina -- 3. Treatment of infertility in polycystic ovary syndrome: ovulation induction / Deborah S. Wachs and R. Jeffery Chang -- 4. Imaging studies in polycystic ovary syndrome / Sophie Jonard,Yann Robert, Yves Ardaens, and Didier Dewailly -- 5. Genes related to metabolic abnormalities or insulin resistance in polycystic ovary syndrome / Hector F. Escobar-Morreale -- 6. Anti-androgens / Kiirşad Ünlühizarci and Fahrettin Keleştimur -- 7. Lipid abnormalities in polycystic ovary syndrome / Djuro Macut -- 8. Serine phosphorylation, insulin resistance, and the regulation of androgen synthesis / Andrew A. Bremer and Walter L. Miller -- 9. Chronic treatment of polycystic ovary syndrome: oral contraceptive pills / Shahla Nader -- 10. Insulin-sensitizing drugs for the treatment of infertility in polycystic ovary syndrome / Cynthia S. Ryan and John E. Nestler -- 11. Diet and lifestyle factors in the etiology and management of polycystic ovary syndrome / R.J. Norman and L.J. Moran -- 12. Adrenarche: the interrelationship of androgens/insulin on the development of the metabolic syndrome/polycystic ovary syndrome / Sharon E. Oberfield, Natasha Leibel, Lauren Antler, Miriam Silfen, Lenore S. Levine, Mary Horlick, Goldy Carbunaru, Ximena Lopez, and Songya Pang -- 13. Cardiovascular disease and inflammation / Francesco Orio, Jr., Evanthia Diamanti-Kandarakis, and Stefano Palomba -- 14. Surgery and laser diathermy / Stefano Palomba, Fulvio Zullo, Evanthia Diamanti-Kandarakis, and Francesco Orio, Jr. -- 15. Late pregnancy complications in polycystic ovary syndrome / Dimitrios Panidis and Neoklis A. Georgopoulos -- 16. Glucose intolerance / Vincenzo Toscano -- 16. Hormonal and biochemical evaluation of polycystic ovary syndrome / Bulent O. Yildiz -- 18. Endometrial carcinoma in polycystic ovary syndrome / Emmanuel Diakomanolis -- 19. Statins, oxidative stress, and polycystic ovary syndrome / Pinar H. Kodaman and Antoni J. Duleba -- 20. Glucose intolerance in polycystic ovary syndrome: focus on the [beta]-cell / David A. Ehrmann -- 21. Polycystic ovary syndrome: definitions and epidemiology / Bart C.J.M. Fauser, Frank J. Broekmans, Joop S.E. Laven, Nick S. Macklon, and Basil Tarlatzis -- 22. Anovulation in polycystic ovary syndrome / Steven Franks -- 23. Nonalcoholic fatty liver disease in polycystic overy syndrome / WalterFutterweit -- 24. "Secondary" polycystic ovary syndrome / Gregory Kaltsas and George Chrousos -- 25. Long-term sequelae of polycystic ovary syndrome: association with insulin resistance and the metabolic syndrome / Richard S. Legro -- 26. The Insulin resistance of polycystic ovary syndrome / Marek Demissie, Richard S. Legro, and Andrea Dunaif -- 27. Therapeutic aspects of polycystic ovary syndrome in adolescence / George Mastorakos, Carolina Koliopoulos, and George Creatsas -- 28. Lifestyle intervention in polycystic ovarian syndrome / Onno E. Janssen, Susanne Tan, and Susanne Hahn -- 29. Involvement of the endocannabinoid system in metabolism and fertility: potential implication in the polycystic ovary syndrome / Uberto Pagotto, Alessandra Gambineri, Valentina Vicennati, and Renato Pasquali -- 30. Insulin resistance: definition and epidemiology in normal women and polycystic ovary syndrome women / Renato Pasquali and Alessandra Gambineri -- 31. Clinical evaluation of polycystic ovary syndrome / Ann E. Taylor -- 32. Pharmaceutical intervention in metabolic and cardiovascular risk factors in polycystic ovary syndrome / Evanthia Diamanti-Kandarakis -- 33. Insulin resistance and early pregnancy loss in polycystic ovary syndrome / Daniela Jakubowicz and Susmeeta T. Sharma.
  • 2013 Springer
    Strachan, Mark W. J.; Frier, Brian M.
    Diabetes is extremely common, with approximately 171 million people affected worldwide. The majority of people with diabetes are cared for in primary care. Primary health care professionals are usually adept at dealing with the lifestyle measures and tablet treatments for diabetes, but generally have limited expertise in the initiation and management of insulin therapy. Insulin therapy has also become more complex, with numerous different forms of insulin and more complex delivery devices available. In a secondary care setting, approximately 10% of in-patients will have diabetes at any one time. People with diabetes stay in hospital longer than people without diabetes, and the condition is often poorly managed during in-patient stays, often leading to clinical errors. Insulin Therapy: A Pocket Guide provides clear and concise information about the safe prescribing of insulin both subcutaneously and intravenously. It covers the different types of insulin, the delivery devices, side effects of insulin and, most importantly, guidance on rational dose adjustment.This book is an invaluable guide for general practitioners and primary care nurses with a special interest in diabetes, as well as junior hospital doctors and specialist medical trainees, advanced nurse practitioners and new diabetes nurse specialists.
  • 2012 Springer
    LeRoith, Derek.
    Epidemiology of IGF-1 and cancer / Katharina Nimptsch and Eward Giovannucci -- Aging and cancer : the IGF- I connection / Kalina Biernacka, Claire Perks, and Jeff Holly -- Obesity, type 2 diabetes and cancer / Rosalyn D. Ferguson and Derek LeRoith -- IGF system and breast cancer / Marc A. Becker and Douglas Yee -- The role of insulin-like growth factor signaling in prostate cancer development and progression / Bruce Montgomery, James Dean, and Stephen Plymate -- IGF-1 cellular action and its relationship to cancer : evidence from in vitro and in vivo studies / Rosalyn D. Ferguson ... [et al.] -- Insulin-like growth factor signaling in pediatric sarcomas / Xiaolin Wan, Su Young Kim, and Lee J. Helman -- Cancer genes, tumor suppressors, and regulation of IGF1-R gene expression in cancer / Haim Werner ... [et al.] -- Mouse models of IGF-1R and cancer / Craig I. Campbell, James J. Petrik, and Roger A. Moorehead -- Targeting the insulin-like growth factor-I receptor in cancer therapy / David R. Clemmons -- Targeting insulin-like growth factor receptor 1 (IGF-1R) and insulin receptor signaling by tyrosine kinase inhibitors in cancer / Joan M. Carboni, Mark Wittman, and Fei Huang -- Calories and cancer : the role of insulin-like growth factor-1 / Stephen D. Hursting ... [et al.] -- Cancer cell metabolism / Akash Patnaik, Jason W. Locasale, and Lewis C. Cantley -- Overlaps between the insulin and IGF-I receptor and cancer / Antonino Belfiore and Roberta Malaguarnera.
  • 2013 Springer
    Talen, Mary R.; Valeras, Aimee Burke.
    Part I: Essentials of Integrated Behavioral Health Care -- Introduction and Overview of Integrated Behavioral Health in Primary Care -- Integrated Behavioral Health and Primary Care: A Common Language -- Integrated Behavioral Health and the Patient-Centered Medical Home -- Advancing Integrated Behavioral Health and Primary Care: The Critical Importance of Behavioral Health in Health Care Policy -- Part II: Review of Integrated Systems of Care Initiatives -- The State of the Evidence for Integrated Behavioral Health in Primary Care -- Community-Based Participatory Research: Advancing Integrated Behavioral Health Care Through Novel Partnerships -- Integrated Behavioral Health in Public Health Care Contexts: Community Health and Mental Health Safety Net Systems -- The Financial History and Near Future of Integrated Behavioral Health Care -- Department of Defense Integrated Behavioral Health in the Patient-Centered Medical Home -- Part III: Review of Collaborative Behavioral Health Clinical Services -- Collaborative Partnerships Within Integrated Behavioral Health and Primary Care -- Identifi cation of Behavioral Health Needs in Integrated Behavioral and Primary Care Settings -- Screening Measures in Integrated Behavioral Health and Primary Care Settings -- Implementing Clinical Interventions in Integrated Behavioral Health Settings: Best Practices and Essential Elements -- Working with Complexity in Integrated Behavioral Health Settings -- Part IV: Connecting Concepts, Research and Practice -- Integrated Behavioral Health in Primary Care: Summarizing the Lay of the Land, Marking the Best Practices, Identifying Barriers, and Mapping New Territory.
  • 2015 PsychiatryOnline
    Raney, Lori E.
    Evidence base and core principles / Jürgen Unützer, Anna Ratzliff -- Collaborative care team in action / Lori Raney, Gina Lasky, Clare Scott -- Role of the consulting psychiatrist / Lori Raney -- Child and adolescent psychiatry in integrated settings / Barry Sarvet, Robert Hilt -- Risk management liability issues in integrated care / Kristin Lambert, Anton Bland -- Training psychiatrists for integrated care / Anna Ratzliff, Jürgen Unützer, Marcella Pascually -- The case for primary care in public mental health settings / Martha Ward, Benjamin Druss -- Providing primary care in behavioral health settings / John Kern -- Behavioral health homes / Joe Parks -- Management of leading risk factors for cardiovascular disease / Erik Vanderlip, Lydia Chwastiak.
  • 2014 Springer
    Kathol, Roger G.; Summergrad, Paul.
    Integrated Care in Psychiatry: Redefining the Role of Mental Health Professionals in the Medical Setting is a landmark title in the field, offering a clear, detailed, and cohesive call by leading experts for coordinated care for patients with concurrent psychiatric and medical conditions. The renowned editors and authors argue that what is slowly occurring, and greatly needed at a faster pace, is nothing less than a sea change in the way that psychiatric care will be delivered. The current, mostly segregated, medical and psychiatric model of care has led to the development of competing medical and psychiatric subcultures that have resulted in a lack of dialog among health providers, administrators, and payers -- and thus in less than optimal patient outcomes. To remedy this problem, the book offers a practical, insightful road map to achieving the central tenet of health reform truly coordinated, patient-centered care where the care experience for the patient, the medical care itself, and the cost outcomes improve as the system changes from fee-for-service to population-based health. An invaluable reference for all clinicians, policy makers, payers, administrators, and others interested in the debate surrounding healthcare systems, Integrated Care in Psychiatry: Redefining the Role of Mental Health Professionals in the Medical Setting is a major contribution to the literature and a gold standard resource.
  • 2008 Springer
    Bohl, Jürgen; Lackner, Karl J.; Sommer, Clemens; Torzewski, M.
  • 2002 CRCnetBASE
    Czarnik, Anthony W.; Mei, Houng-Yau.
  • 2010
    Daniels, Jonathan Spencer; Kenny, Thomas W.; Lee, Thomas H.; Pourmand, Nader.
    Affinity biosensors are important tools for detecting DNA, proteins, cells, and other biomedical analytes. Although optical readout is prevalent, impedance readout is promising for many applications due to lower cost, reduced system size, and label-free operation. Impedance biosensors detect the binding of a target biomolecule to an immobilized probe by quantifying changes in the the electrode-electrolyte interface impedance. Impedance biosensors traditionally use bulky and expensive instruments to monitor the impedance of a single electrode. We describe miniaturized and inexpensive readout circuitry for an array of such sensors. By using a sensor array, multiple analytes can be simultaneously detected and limitations inherent to individual sensors can be mitigated. Reducing the size and cost of the measurement system enables new applications. We present a measurement system for a 6x6 array of impedance biosensors built from off-the-shelf components. Experimental results with DNA probe-target pairs confirm others' reports that changes in the interface impedance can signify binding. Other experiments with proteins demonstrate that changes in the nonlinearity of the I-V relationship can also indicate probe-target binding. We show that the impedance and the nonlinearity can be quantified simultaneously by superimposing a large-amplitude tone on the impedance-measurement tone and analyzing the resulting intermodulation tones. We conclude by describing an integrated array of measurement circuits implemented in 0.18 um CMOS. Each of the 36 measurement pixels contains an impedance-measuring circuit plus tone cancellation circuitry, which enables simultaneous nonlinearity measurement. To prevent the large-amplitude excitation from saturating the amplifier output, a per-pixel digital feedback loop injects an appropriate cancelling current at the amplifier input. Impedance changes of 0.2% can be detected using the integrated measurement circuit. Each pixel occupies 0.14 mm2 and consumes 1.9 mW.
  • 2002 CRCnetBASE
    Guttman, András; Heller, Michael J.
  • 2013 Springer
    Bourke, S. J.; Peel, E. Timothy.
    This book brings together the knowledge, skills and attitudes of specialists in both Respiratory Medicine and Palliative Medicine to focus on the palliative care of patients with respiratory diseases. It deals not only with end-of-life care but also with symptom control and supportive care to improve the quality of life of those living their lives with advanced progressive lung disease.
  • 2009 Springer
    Buscombe, John R.; Gnanasegaran, Gopinath; Hall, Margaret; Movahed, Assad.
  • 2006
    Schmalz, Michael.
    PrintStatus: Not Checked OutLane Catalog Record
    Introduction to Access/Excel integration -- Using the Excel user interface -- Data access from Excel VBA -- Integration from the access interface -- Using access VBA to automate Excel -- Using Excel charts and pivot tables with access data -- Leveraging SQL server data with Microsoft Office -- Advanced Excel reporting techniques -- Using Access and Excel data in other applications -- Creating form functionality in Excel -- Building graphical user interfaces -- Tackling an integration project.
  • 2013 Springer
    Belin, Pascal; Campanella, Salvatore; Ethofer, Thomas.
    This book follows a successful symposium organized in June 2009 at the Human Brain Mapping conference. The topic is at the crossroads of two domains of increasing importance and appeal in the neuroimaging/neuroscience community: multi-modal integration, and social neuroscience. Most of our social interactions involve combining information from both the face and voice of other persons: speech information, but also crucial nonverbal information on the person's identity and affective state. The cerebral bases of the multimodal integration of speech have been intensively investigated; by contrast only few studies have focused on nonverbal aspects of face-voice integration. This work highlights recent advances in investigations of the behavioral and cerebral bases of face-voice multimodal integration in the context of person perception, focusing on the integration of affective and identity information. Several research domains are brought together. Behavioral and neuroimaging work in normal adult humans included are presented alongside evidence from other domains to provide complementary perspectives: studies in human children for a developmental perspective, studies in non-human primates for an evolutionary perspective, and studies in human clinical populations for a clinical perspective.
  • 2008 WHO
    PART 1: Primary care for mental health in context -- Chapter 1. Primary care for mental health within a pyramid of health care -- Chapter 2. Seven good reasons for integrating mental health into primary care -- -- PART 2: Primary care for mental health in practice -- Introduction -- Argentina: Physician-led primary care for mental health in Neuquén province, Patagonia region -- Australia: Integrated mental health care for older people in general practices of inner-city Sydney -- Brazil: Integrated primary care for mental health in the city of Sobral -- Chile: Integrated primary care for mental health in the Macul district of Santiago -- India: Integrated primary care for mental health in the Thiruvananthapuram District, Kerala State -- Islamic Republic of Iran: Nationwide integration of mental health into primary care -- Saudi Arabia: Integrated primary care for mental health in the Eastern Province -- South Africa: Integrated primary care services and a partnership for mental health primary care -- Ehlanzeni District, Mpumalanga Province, and Moorreesburg District, Western Cape Province -- Uganda: Integrated primary care for mental health in the Sembabule District -- United Kingdom of Great Britain and Northern Ireland: Primary care for mental health for disadvantaged communities in London -- -- Report conclusions -- -- Annex 1: Improving the practice of primary care for mental health
    Also available: Print – 2008
  • 2009
    Race, Elizabeth Anne.
    PrintStatus: Not Checked OutLane Catalog Record
  • 2007 CRCnetBASE
    Bowers, Jennifer Muir; Marian, Mary; Williams-Mullen, Pamela.
    Fundamentals of integrative nutrition / Cynthia A. Thomson and Robert Lutz -- Ayurveda: the mother of traditional medicine / Mari Clements -- Pregnancy and lactation / Amy A. Drescher, Deborah Pesicka, and Judith Shabert -- Infant and child health / Lisbeth Benoit -- Adolescence / Mary Marian, Richard Wahl, and John D. Mark -- Women's health / Pamela Echeverria and Jyotsna Sahni -- Men's health / Aaron W. Crawford -- Skeletal system and joint health / Lisa High ... [et al.] -- Cardiovascular disease / Ellen Augur and Mary Atkinson -- Nervous system / Ame Golaszewski and Leo McCluskey -- Upper gastrointestinal system / Andrea Avery and Pamela Williams -- Promoting small and large bowel health / Susan Roberts and Mary Krystofiak Russell -- Liver disease / Roschelle Heuberger -- Nutrition and the pancreas / M. Patricia Fuhrman ... [et al.] -- Immune system / Ellyn Silverman ... [et al.] -- Renal nutrition / Margaret Furtado and Carlos DaSilva -- Respiratory health / Jennifer Doley, Richard Berry, and Mary Marian -- Ear health / Duke Johnson -- Skin health / Jennifer Doley and Joseph Genebriera. Fundamentals of integrative nutrition / Cynthia Thomson and Robert Lutz -- Ayurveda: the mother of traditional medicine / Mary Clements -- Pregnancy and lactation / Amy Drescher and Judith Shabert -- Infancy & childhood / Lisbeth Benoit and Pamela Williams -- Adolescence / Mary Marian, Richard Wahl, and John D. Mark -- Women's health / Pam Echeverria and Jotysna Sani -- Men's health / Aaron Crawford -- Skeletal & joint health / Lisa High ... [et al.] -- Cardiovascular health / Ellen Augur and Mary Atkinson -- Nervous system / Ame Golaszewski and Leo McCluskey -- Upper gastrointestinal health / Andrea Avery and Pamela Williams -- Diseases of the small and large bowel / Susan Roberts and Mary Russell -- Liver health / Roschelle Heuberger -- Nutrition and the pancreas / M. Patricia Fuhrman ... [et al.] -- The immune system / Ellyn Silverman ... [et al.] -- Renal health / Margaret Furtado and Carlos DaSilva -- Respiratory health / Richard Berry -- Ear health / Duke Johnson -- Skin health / Jennifer Doley and Joseph Genebriera.
  • 2008 Springer
    Poulin, Marc J.; Wilson, Richard J. A.
    Also available: Print – 2008
  • v. 1-3, 1952-.
    French, Thomas Morton.
    PrintStatus: Not Checked OutLane Catalog Record
    v. 1. Basic postulates -- v. 2. Integrative process in dreams -- 3. The Reintegrative process in a psychoanalytic treatment.
  • 2011
    Chen, David Pei-Ann; Altman, Russ B.; Butte, Atul J.; Walker, Michael G.
    Secondary use of electronic health record (EHR) data has the potential to unlock novel insight into human pathophysiology. While EHR data has often been used in retrospective studies, management of public health, and to improve patient safety, its use in discovering underlying molecular mechanisms of human disease and pathophysiology has been limited. Much of this can be attributed to the differing priorities between healthcare providers and basic biological researchers. The advent of biobanks that collect physiological measurements as well as tissue samples and molecular measurements promises to address this issue. However, the sheer number of different biological and clinical measurement modalities hinders the generation of a truly complete view of the human organism. The increased adoption of EHRs as well as growing biological data repositories enables researchers to answer biological questions applicable to the human population. The goal is not to treat humans as experimental organisms, but rather to gain as much knowledge as possible from every patient seen. By viewing EHRs as a repository of perturbations and their associated physiological consequences we can begin to design experiments that leverage EHR data to generate hypotheses that can be further evaluated. This thesis aims to describe methods to summarize EHR biomarker data in a systematic way to enable downstream analysis as well as methods for integrating EHR data and disparate biological data. I will describe the creation of the "clinarray" and its application to specific disease populations to differentiate patients by severity and to discover latent physiological factors associated with disease. I will also describe how to aggregate and analyze clinarrays from across the EHR to build models of aging. Finally I will discuss the use of diseases to integrate EHR data with gene expression data from a disparate biological data source to discover genes related to aging and to generate hypotheses for relationships between biomarkers and genes. The integration of readily available clinical and biological data promises to improve our understanding of phenomics without impacting patient care and adding an unnecessary burden to the healthcare system. It is important for biological research to leverage the increased amount of molecular and environmental data stored in EHRs to build a more complete view of the human organism.
  • 2015
    Schafer, Peter; Calvo, Michele.
    This study reveals the many opportunities and challenges facing harm reduction providers and their healthcare provider partners as they work to improve and expand the integration of harm reduction and healthcare services. Key informant interviews, focus groups, a comprehensive literature review, and an in-depth case study of a successful co-location model of service integration uncovered effective strategies and instructive experiences to guide integration efforts.
  • 2012 Springer
    Powell, Valerie.
    Rationale and Need to Articulate Medical and Dental Data / Valerie J.H. Powell, Franklin M. Din -- HIT Considerations: Informatics and Technology Needs and Considerations / Miguel Humberto Torres-Urquidy -- Metrics and Measurements / Valerie J.H. Powell, Amit Acharya -- Broader Considerations of Medical and Dental Data Integration / Stephen Foreman, Joseph Kilsdonk -- International Perspectives / Miguel Humberto Torres-Urquidy -- An Integrated Medical-Dental Electronic Health Record Environment: A Marshfield Experience / Amit Acharya, Natalie Yoder, Greg Nycz -- Conclusion and Recommendations / Franklin M. Din, Valerie J.H. Powell.
  • 2012 Cambridge
    Bettinger, Christopher.
    Progress towards Melanin Integration in Bio-Inspired Devices. -- Bio Organic-Based Gate Dielectric Materials for Thin Film Transistors.
  • 2011
    Rorie, Alan E.; Knutson, Brian; Moore, Tirin; Newsome, William T.; Shenoy, Krishna V.
    The work presented in this dissertation primarily focuses on decision-related activity in the lateral intraparietal area (LIP) and, secondarily, the dorsolateral prefrontal cortex (DLPFC). In Chapter 1 we review the previous independent investigations indicating that these areas are separately modulated by sensory information, value information and choice appropriate to represent decisions. We argue that when both sensory and value information must be simultaneously integrated to make choices, it is unknown, if, how and when these areas integrate these factors. We present a behavioral paradigm in which animal subjects must combine sensory and value information, on a trial-to-trial basis, to make optimal choices. This paradigm is based on a well-known motion discrimination task; however, in our task the magnitude of the reward associated with each option varies from trial to trial. On some trials both options are worth equally large or small rewards. On other trials one option's reward is greater than that of the other. In Chapter 2, we demonstrate that in the unequal reward conditions subjects' choices are consistently biased towards the greater magnitude option. Additionally, we will show that this bias is independent of the motion stimulus strength and its magnitude is nearly optimal. In Chapter 3, we observe that single neurons in cortical area LIP consistently, simultaneously and dynamically represent both sensory and value information. We will argue that this representation supports an integrator model of decision making, in which sensory information is accumulated until the decision is resolved by a threshold crossing. Our results support an interpretation of this model in which value information adjusts the likelihood of a threshold crossing by iv raising or lowering the accumulator's initial state. In Chapter 4, we present a preliminary comparison between LIP and DLPFC activity, under identical conditions, suggesting they play fundamentally different roles in decision making. In Chapter 5, we discuss future lines of research.
  • 2005 Springer
    Meadows, Gary G.
    Microenvironmental effects on tumour progression and metastasis -- Role of microenvironment on gene expression, angiogenesis and microvascular function in tumors -- Imaging of angiogenesis in vivo with fluorescent proteins -- The epigenetic influence of the tumor microenvironment on melanoma plasticity -- Dynamics of cell adhesion interactions during melanoma development -- Matrix metalloproteinases: mediators of tumour-host cell interactions -- Role of brain microenvironments in brain metastases -- Influence of the bone microenvironment on breast cancer metastasis to bone -- Interaction of tumour with host stroma in hepatocellular carcinoma -- Dynamic nature of tumour-host interactions within the tumor microenvironment -- Breast cancer progression: a "vicious cycle" of pro-malignancy activities is mediated by inflammatory cells, chemokines and cytokines -- Tumor and host endothelial cell selective interactions and modulation by microenvironmental chemokines: tumor-endothelial cell cross talk specificity -- The role of chemokine receptors, in particular CXCR4, in lymphoma and carcinoma metastasis -- Energy homeostasis and the tumor/host interaction: the role of the brain -- Anti-angiogenic and pro-apoptotic effects of dietary restriction in experimental brain cancer: role of glucose and ketone bodies -- Dietary restriction of specific amino acids modulates tumor and host interactions -- Role of tumour microenvironment in chemoresistance -- Integrin-mediated resistance to chemotherapy-induced apoptosis in cancer cells -- Bone metastasis microenvironment participates in the development of androgen ablation refractoriness and chemotherapy resistance of prostate cancer cells residing in the skeleton: clinical implications -- Current and future therapeutic targets of the tumour-host microenvironment -- Bone stromal cells as therapeutic targets in osseous metastasis -- Organtropism of lung cancer metastasis and its molecular targeted therapy -- Maspin: a novel serine protease inhibitor -- Metastasis suppressor genes: a brief review of an expanding field -- Tumor-host interactions at the metastatic site: MKK4, signal transduction and the stress response.
  • 2013 Springer
    Spangenburg, Espen E.
    The purpose of Integrative Biology of Women's Health is to discuss and identify perspective areas from basic science to clinical interventions that are critical to the future of women's health. As of now there are critical knowledge gaps that exist in our understanding of physiological and cellular function in women that make the prediction of responses to specific interventions daunting. From a scientific evolution of understanding, the existence of research focused on women's health is relatively new and thus there has not been enough time for new information to integrate itself into our current scientific thought process. This book seeks to capture and disseminate our current understanding of scientific advancements relevant to women's health and provide the information to a broad audience. The scientific community has made significant advancements in understanding the unique aspects of women's health in multiple different tissues. Within this book leading researchers in three key areas: skeletal-muscle-bone function, metabolic function, and cardiovascular function have contributed chapters to enlighten or encourage new avenues of thought that would benefit women. The reader will be exposed to a wide range of experimental approaches including physiological, biochemical, molecular techniques in an effort to provide a comprehensive discussion about the biology of women's health.-- Source other than Library of Congress.
  • 2009 IOM
    Maizes, Victoria; Rakel, David P.
    Integrative medicine has emerged as a potential solution to the American health care crisis. It provides care that is patient-centered, healing oriented, emphasizes the therapeutic relationship, and uses therapeutic approaches originating from conventional and alternative medicine. Initially driven by consumer demand, the attention integrative medicine places on understanding whole persons and assisting with lifestyle change is now being recognized as a strategy to address the epidemic of chronic diseases bankrupting our economy. This paper defines integrative medicine and its principles, describes the history of complementary and alternative medicine (CAM) in American health care, and discusses the current state and desired future of integrative medical practice. The importance of patient-centered care, patient empowerment, behavior change, continuity of care, outcomes research, and the challenges to successful integration are discussed. The authors suggest a model for an integrative health care system grounded in team-based care. A primary health partner, who knows the patient well, is able to addresses mind, body and spiritual needs, and coordinates care with the help of a team of practitioners is at the centerpiece. Collectively, the team can meet all the health needs of the particular patient and forms the patient centered medical home. The paper culminates with ten recommendations directed to key actors to facilitate the systemic changes needed for a functional health care delivery system. Recommendations include creating financial incentives aligned with health promotion and prevention. Insurers are requested to consider the total costs of care, the potential cost-effectiveness of lifestyle approaches and CAM modalities, and the value of longer office visits to develop a therapeutic relationship and stimulate behavioral change. Outcomes research to track the effectiveness of integrative models must be funded, as well as feedback and dissemination strategies. Additional competencies for primary health partners, including CAM and conventional medical providers, will need to be developed to foster successful integrative practices. Skills include learning to develop appropriate health care teams that function well in a medical home, developing an understanding of the diverse healing traditions, and enhancing communication skills. For integrative medicine to flourish in the U.S., new providers, new provider models, and a realignment of incentives and a commitment to health promotion and disease management will be required.
  • 2009
    Loo, May.
    PrintStatus: Not Checked OutLane Catalog Record
  • 2012 ClinicalKey
    Rakel, David P.
    Pt. 1 Integrative medicine -- Philosophy of integrative medicine -- Creating optimal healing environments -- The healing encounter -- Pt. 2 Integrative approach to disease -- Affective disorders -- Depression -- Anxiety -- Attention deficit hyperactivity disorder -- Autism spectrum disorder -- Insomnia -- Neurology -- Alzheimer disease -- Headache -- Peripheral neuropathy -- Multiple sclerosis -- Parkinson disease -- Infectious disease -- Otitis media -- Chronic sinusitis -- Viral upper respiratory infection -- HIV disease and AIDS -- Herpes simplex virus -- Chronic hepatitis - Urinary tract infection -- Recurrent yeast infections Lyme disease -- Cardiovascular disease -- Hypertension -- Hearat failure -- Coronary artery disease -- Peripheral vascular disease -- Arrhythmias -- Allergy intolerance -- Asthma -- The allergic patient -- Multiple chemical sensitivity syndrome - Metabolic endocrine disorders -- Insulin resistance and the metabolic syndrome -- Type 2 diabetes -- Hypothroidism -- Hormone replacement in men -- Hormone replacement in women -- Polycystic ovarian syndrome -- Osteoporosis -- An integrative approach to obesity -- Dyslipidemias -- Gastroesophageal reflux disease -- Peptic ulcer disease - Cholelithiasis -- Recurring abdominal pain in pediatrics -- Constipation -- Autoimmune disorders --Fibromyalgia -- Chronic fatigue spectrum -- Rheumatoid arthritis --Inflammatory bowel disease -- Obstetrics gynecology -- Postdates pregnancy -- Labor pain management -- Nausea and vomiting in pregnancy -- Premenstrual syndrome -- Dysmenorrhea -- Uterine fibroids (Leiomyomata) -- Vaginal dryness --; Uroloogy -- Benign prostatic hyperplasia -- Urolithiasis -- Chronic prostatitis -- Erectile dysfunction -- Musculoskeletal Disorders -- Osteoarthritis -- Myofascial pain syndrome -- Chronic low back pain -- Neck pain -- Gout -- Carpal tunnel syndrom -- Epicondylitis -- Dermatology --Atopic dermatitis -- Psoriasis -- Urticaria -- Recurrent aphthous ulceration -- Seborrheic dermatitis -- Acne Vulgaris and acne rosacea -- Human papillomavirus and warts -- Cancer -- Breast cancer -- Lung cancer -- Prostate cancer -- Colorectal cancer -- Skin cancer -- End of life care -- Substance abuse -- Alcoholism and substance abuse -- Ophthalmology -- Cataracts -- Ade related macular degeneration -- Pt. 3 Tools for your practice -- Lifestyle -- Food intolerance and elimination diet -- The glycemic index load -- The antiinflammatory diet -- The DASH diet -- Writing an exercise prescription -- Breathing exercises -- Low back pain exercises -- Mind body -- Self hypnosis techniques -- Relaxatin techniques -- Enhancing heart rate variability -- Guided imagery and interactive guided imagery -- Journaling for health -- Healing through forgiveness -- recommending meditation -- Motivational interviewing -- Emotional awareness for pain -- energy psychology -- Biochemical -- Prescribing probiotics -- Prescribing botanicals -- Detoxification -- Integrative strategies for planetary health -- Biomechanical --; Counterstrain -- Acupuncture for headache -- Acupuncture for nausea and vomiting -- Saline nasal irrigation -- Bioenergetics -- Integrating spiritual assessment and care -- Therapeutic homeopathy -- Human energetic therapies -- Other therapeutic considerations -- Creating a greener clinic: the impact of global warming on health -- Creating ceremony and ritual in the medical encounter -- Appendix: laboratory testing resources in integrative medicine.
  • 2009
    Lake, James.
    PrintStatus: Not Checked OutLane Catalog Record
    The context of integrative mental health care -- Evaluating a client from an integrative perspective : the intake interview, assessment, and formulation -- Recommending treatment and making referrals -- Moderate and severe depression -- Cyclic mood changes and mania -- Anxiety and panic -- Hyperactivity and distractibility -- Psychotic symptoms and schizophrenia -- Mild cognitive impairment and dementia -- Alcohol and drug abuse -- Insomnia and fatigue.
  • 2012
    Schaub, Marc Andreas; Batzoglou, Serafim; Butte, Atul J.; Dill, David.
    Genome Wide Association Studies (GWAS) have identified over 4,500 common variants in the human genome that are statistically associated with diseases and other phenotypical traits. Most identified associations, however, only have a small effect on disease risk, and their relevance in a clinical setting remains the subject of extensive debate. In this thesis I present three integrative analysis directions that extend on GWAS by developing new methods, by using genotyping data to ask new questions, and by integrating additional types of data to generate functional hypotheses about the biological processes underlying associations. First, I introduce a new classifier-based methodology that identifies similarities in the genetic architecture of diseases. This method can successfully identify both known and novel relationships between common diseases. Second, I show how control individuals from a GWAS can be used to detect genetic differences between the pseudoautosomal regions of chromosomes X and Y in the general population. Finally, I present an approach that integrates experimental data generated by the ENCODE consortium in order to identify functional Single Nucleotide Polymorphisms (SNPs). These functional SNPs are associated with a phenotype, either directly or through linkage disequilibrium, and overlap a functional region of the genome such as a transcribed region or a transcription factor binding site. Up to 80% of all associations previously reported in a GWAS can be mapped to a functional SNP.
  • 2010
    Ouyang, Zhengqing; Feldman, Marcus W.; Petrov, Dmitri A.; Wong, Wing Tak.
    High-throughput genomics has been increasingly generating the massive amount of genome-wide data. With proper modeling methodologies, we can expect to archive a more comprehensive understanding of the regulatory mechanisms of biological systems. This work presents integrative approaches for the modeling and analysis of gene regulatory systems. In mammals, gene expression regulation is combinatorial in nature, with diverse roles of regulators on target genes. Microarrays (such as Exon Arrays) and RNA-Seq can be used to quantify the whole spectrum of RNA transcripts. ChIP-Seq is being used for the identification of transcription factor (TF) binding sites and histone modification marks. RNA interference (RNAi), coupled with gene expression profiles, allow perturbations of gene regulatory systems. Our approaches extract useful information from those genome-wide measurements for effectively modeling the logic of gene expression regulation. We present a predictive model for the prediction of gene expression from ChIP-Seq signals, based on quantitative modeling of regulator-gene association strength, principal component analysis, and regression-based model selection. We demonstrate the combinatorial regulation of TFs, and their power for explaining genome-wide gene expression variation. We also illustrate the roles of covalent histone modification marks on predicting gene expression and their regulation by TFs. We present a dynamical model of gene expression profiling, and derive the perturbed behaviors of the ordinary differential equation (ODE) system. Based on that, we present a regularized multivariate regression method for inferring the gene regulatory network of a stable cell type. We model the sparsity and stability of the network by a regularization approach. We applied the approaches to both a simulation data set and the RNAi perturbation data in mouse embryonic stem cells.
  • 2008 Springer
    Cohen, Lorenzo; Markman, Maurie.
    Introduction -- A word of caution: risk of harm associated with alternative complementary/integrative approaches in cancer management and the critical need for quality research to understand and decrease that risk -- Using legal and ethical principles to guide clinical decision making in complementary/integrative cancer medicine -- Communicating with patients about the use of complementary and integrative medicine in cancer care -- The integrative medicine program at The University of Texas M. D. Anderson Cancer Center -- The integrative medicine service at Memorial Sloan-Kettering Cancer Center -- Integrative oncology-Leonard P. Zakim Center: the Dana-Farber Cancer Institute experience -- The Johns Hopkins complementary and integrative medicine service -- Integrative oncology at Mayo Clinic: research informing practice -- Mind-body research in cancer -- Herbs and other botanicals: interactions with pharmaceuticals -- Acupuncture in cancer care at Dana-Farber Cancer Institute: an integrative medical practice -- Acupuncture for the side effects of cancer treatments.
  • 2008 Springer
    Audette, Joseph F.; Bailey, Allison.
  • 2012 Springer
    Längler, Alfred; Mansky, Patrick J.; Seifert, Georg.
    This practice-oriented handbook covers complementary and alternative medicine (CAM) practices in pediatric oncology worldwide, with a focus on methods used in Western countries. Provides a road map for establishing integrative pediatric oncology worldwide.
  • 2005 Springer
    Walz, Wolfgang.
  • 2003 ScienceDirect
    Romeo, John T.
    The enzymatic basis of flavonoid biodiversity / Ragai K. Ibrahim and Dominique Anzellotti -- Structural, functional and evolutionary basis for methylation of plant small molecules / Joseph P. Noel ... [et al.] -- Regulation of anthocyanin pigmentation / Niloufer G. Irani, J. Marcela Hernandez and Erich Grotewold -- Localization of plant myrosinases and glucosinolates / Erik Andreasson and Lise Bolt Jorgensen -- Glucosinolate hydrolysis and its impact on generalist and specialist insect herbivores / Ute Wittstock ... [et al.] -- A novel myrosinase-glucosinolate defense system in cruciferous specialist aphids / John T. Rossiter, Alexnadra M. Jones and Atle M. Bones -- Multiple levels of control in the regulation of alkaloid biosynthesis / Peter J. Facchini ... [et al.] -- Biochemistry and molecular biology of indole alkaloid biosynthesis : the implication of recent discoveries / Vincenzo de Luca -- Chemical ecology of alkaloids exemplified with the pyrrolizidines / Dietrich Ober -- The chemical wizardry of isoprenoid metabolism in plants / Bryan T. Greenhagen ... [et al.] -- The sabath family of MTS in Arabidopsis Thaliana and other plant species / John C. D'Auria, Feng Chen, Eran Pichersky -- Xochipilli updated, terpenes from Mexican plants / Edmundo Lozoya-Gloria.
  • 2006 ScienceDirect
    Romeo, John T.
    Terpene indole alkaloid biosynthesis / Sarah E. O'Connor, Elizabeth McCoy -- Pathways to diverse ergot alkaloid profiles in fungi / Daniel G. Panaccione, Christopher L. Schardl, Christine M. Coyle -- Compartmentalization of plant secondary metabolism / Nailish Samanani, Peter J. Facchini -- Comparative genomics of the shikimate pathways in Arabidopsis, Populus trichocarpa and Oryza sativa : shikimate pathway gene family structure and identification of candidates for missing links in pehnylalanine biosynthesis / Björn Hamberger ... [et al.] -- Tomato glandular trichomes as a model system for exploring evolution of specialized metabolism in a single cell / Eyal Fridman ... [et al.] -- Anacardic acid biosynthesis and bioactivity / David J. Schultz, Nalinie S. Wickramasinghe, Carolyn M. Klinge -- Molecular and biochemical investigations of sorgoleone biosynthesis / Daniel Cook ... [et al.] -- Biosynthesis of terpenophenolic metabolites in hop and cannabis / Jonathan E. Page, Jana Nagel -- Engineering pathway enzymes to understand the function and evolution of sterol structure and activity / Pruthvi Jayasimha ... [et al.] -- Methylation and demethylation of plant signaling molecules / Yue Yang ... [et al.] -- Recent advances in auxin biosynthesis and conjugation / Amber Kei Bowers, Yunde Zhao -- Auxin biology and biosynthesis / Jessica Calio, Yuen Yee Tam, Jennifer Normanly -- Translational opportunities in plant biochemistry / Cecilia A. McIntosh.
  • 2012 Springer
    Chlan, Linda; Hertz, Marshall I.
    Overview of integrative therapies and healing practices -- Evaluation of integrative therapies for research and practice -- Integrative therapies in chronic pulmonary conditions -- Integrative therapies for people with asthma -- Integrative therapies for people with asthma -- Integrative therapies for people with chronic obstructive pulmonary disease -- Integrative therapies for people with interstitial lung disease, idiopathic pulmonary fibrosis, and pulmonary arterial hypertension -- Integrative therapies for people with cystic fibrosis -- Integrative therapies for people with lung cancer -- Integrative therapies for lung transplantation recipients -- Integrative therapies in critical care and sleep disorders -- Integrative therapies in the management of critically ill patients -- Integrative therapies to promote sleep in the intensive care unit -- Future application of integrative therapies for sepsis: bench and experimental animal models -- Integrative therapies to manage acute and chronic sleep disorders -- Integrative therapies to promote lung health -- Integrative therapies for tobacco cessation -- Integrative therapies to support palliative and end-of-life care in lung disease -- Whole medical systems in lung health and sleep: focus on traditional Chinese medicine -- Counseling patients with chronic lung disease: interdisciplinary strategies for reducing distress.
  • 2014 CRCnetBASE
    Blush, Joel A.
    "This book provides practical hands-on advice on the use of alternative methods of hypertension treatment. It describes mechanisms of high blood pressure and hypertension, common causes of hypertension, and standard medications used to treat the disease and their side effects. The book details alternative methods of treating hypertension, emphasizing their mechanisms of action, similarities to standard medications, and practical implementation advice. Finally, it outlines guidelines for blood pressure goals, categorizes each treatment as medicine or alternative, and suggests ways of implementing an integrative approach to hypertension treatment"--Provided by publisher.
  • 2014 Springer
    Cheskin, Lawrence J.; Matarese, Laura E.; Mullin, Gerard E.
    Integrative Weight Management: A Guide for Clinicians intends to educate physicians and nutritionists about the wide ranges of approaches to weight control from non-traditional sources. The options for weight management in conventional practices are limited to a small number of medications, a confusing array of dietary approaches and surgical procedures with their inherent risks and complications. Unfortunately medical practitioners are not exposed to nutrition and weight control principles during training and thus are reluctant to manage their patients weight control issues. This volume is structured into 4 sections: Introduction to Weight Management Disorders; Morbidity and Mortality of Obesity; Therapy of Obesity; and Integrative Medicine and Obesity. Integrative Weight Management: A Guide for Clinicians represents a powerful collaboration of dozens of leading experts in the fields of nutrition, weight management and integrative medicine who have managed countless numbers of patients and summarized the research from thousands of articles to create an up-to- date state of the art guide for healthcare practitioners, allied health professionals and public health authorities who manage those who are overweight/obese along with the associated metabolic consequences.
  • 2011 Springer Protocols
    Shimaoka, Motomu.
    Overview : assays for studying integrin-dependent cell adhesion / Alexandre Chigaev and Larry A. Sklar -- Cell adhesion assays / Gabriele Weitz-Schmidt and Stephanie Chreng -- Real-time analysis of integrin-dependent transendothelial migration and integrin-independent interstitial motility of leukocytes / Ziv Shulman and Ronen Alon -- Lentiviral gene transfer method to study integrin function in T lymphocytes / Daliya Banerjee and Motomu Shimaoka -- Surface plasmon resonance biosensing in studies of the binding between b2 integrin I domains and their ligands / Thomas Vorup-Jensen -- Cell-free ligand-binding assays for integrin LFA-1 / Koichi Yuki -- Overview : structural biology of integrins / Guanyuan Fu, Wei Wang, and Bing-Hao Luo -- Protein expression and purification of integrin I domains and IgSF ligands for crystallography / Hongmin Zhang and Jia-huai Wang -- Electron microscopic imaging of integrin / Kenji Iwasaki -- NMR method to study protein-protein interactions / Noritaka Nishida and Ichio Shimada -- Single-molecule methods to study cell adhesion molecules / Joonil Seog -- Overview : imaging in the study of integrins / Christopher V. Carman -- Live imaging of LFA-1-dependent T-cell motility and stop signals / Andrew J. Wiemer, Sarah Wernimont, and Anna Huttenlocher -- Monitoring integrin activation by fluorescence resonance energy transfer / Craig T. Lefort, Young-Min Hyun, and Minsoo Kim -- High-resolution fluorescence microscopy to study transendothelial migration / Christopher V. Carman -- Multiphoton intravital microscopy to study lymphocyte motility in lymph nodes / Thomas T. Murooka and Thorsten R. Mempel -- Overview of integrin signaling in the immune system / Tatsuo Kinashi -- Rap1 and integrin inside-out signaling / Koko Katagiri and Tatsuo Kinashi -- Isolation of focal adhesion proteins for biochemical and proteomic analysis / Jean-Cheng Kuo [and others] -- Talin and signaling through integrins / Mohamed Bouaouina, David S. Harburger, and David A. Calderwood -- Proteomics method for identification of pseudopodium phosphotyrosine proteins / Yingchun Wang and Richard L. Klemke -- Overview : studying integrins in vivo / Clifford A. Lowell and Tanya N. Mayadas -- Method for the generation of conditional gene-targeted mice / Masahiro Yamamoto and Kiyoshi Takeda -- T-cell homing to the gut mucosa : general concepts and methodological considerations / Jaime De Calisto [and others] -- In vivo quantitative proteomics : the SILAC mouse / Sara Zanivan, Marcus Krueger, and Matthias Mann -- Analysis of chemotaxis in Dictyostelium / Huaqing Cai [and others] -- Integrins in tumor angiogenesis and lymphangiogenesis / Philippe Foubert and Judith A. Varner -- PET-radioimmunodetection of integrins : imaging acute colitis using a 6464Cu-labeled anti-B7 integrin antibody / Jason L.J. Dearling and Alan B. Packard -- Integrin-targeted nanoparticles for siRNA delivery / Noa Ben-Arie, Ranit Kedmi, and Dan Peer -- Humanized mice for studying human leukocyte integrins in vivo / Sang-Soo Kim [and others].
  • 2007 ScienceDirect
    Cheresh, David A.
    Also available: Print – 2007
  • 2010 Springer
    Arcangeli, Annarosa; Becchetti, Andrea.
    Integrin structure and functional relation with ion channels / Annarosa Arcangeli and Andrea Becchetti -- Introduction to ion channels / Chiara Di Resta and Andrea Becchetti -- Biochemical methods to study the interactions between integrins and ion channels / Olivia Crociani -- Optical methods in the study of protein : protein interactions / Alessio Masi ... [et al.] -- Integrins and signal transduction / -- Sara Cabodi ... [et al.] -- Physical and functional interaction between integrins and herg1 channels in cancer cells / Serena Pillozzi and Annarosa Arcangeli -- Coordinated regulation of vascular Ca2+ and K+ channels by integrin signaling / Peichun Gui ... [et al.] -- Adhesion : dependent modulation of macrophage K+ channels / Margaret Colden-Stanfield -- Integrin receptors and ligand : gated channels / Raffaella Morini and Andrea Becchetti -- Integrins and ion channels in cell migration : implications for neuronal development, wound healing and metastatic spread / Andrea Becchetti and Annarosa Arcangeli.
    Also available: Print – 2010
  • 2014 Springer
    Brougher, Joanna T.
    Introduction to intellectual property -- Obtaining, enforcing and defending patents -- The patent-eligibility of genes -- Medical procedure patents -- Rights and roles of universities and inventors -- Drug development : balancing innovation, access and profits -- Patent battles part I : small-molecule drugs -- Patent battles part II : the Biosimilars Act and biologics -- International patent law, trade law, and access to drugs.
  • 2008 CRCnetBASE
    Burnham, Keith J.; Haas, Olivier.
  • 2002 Wiley
    Mann, Steve.
    ch. 1. Humanistic Intelligence as a Basis for Intelligent Image Processing, p. 1-14 -- ch. 2. Where on the Body is the Best Place for a Personal Imaging System?, p. 15-63 -- ch. 3. The EyeTap Principle: Effectively Locating the Camera Inside the Eye as an Alternative to Wearable Camera Systems, p. 64-102 -- ch. 4. Comparametric Equations, Quantigraphic Image Processing, and Comparagraphic Rendering, p. 103-178 -- ch. 5. Lightspace and Antihomomorphic Vector Spaces, p. 179-232 -- ch. 6. VideoOrbits: The Projective Geometry Renaissance, p. 233-294 -- Appendix A. Safety First! (page 295 -- Appendix B. Multiambic Keyer for Use While Engaged in Other Activities, p. 296-318 -- Appendix C. WearCam GNUX Howto, p. 319-324 -- Appendix D. How to Build a Covert Computer Imaging System into Ordinary Looking Sunglasses, p. 325-331.
  • 2013 ScienceDirect
    Ahamed, Syed V.
    This textbook offers an insightful study of the intelligent Internet-driven revolutionary and fundamental forces at work in society. Readers will have access to tools and techniques to mentor and monitor these forces rather than be driven by changes in Internet technology and flow of money. These submerged social and human forces form a powerful synergistic foursome web of (a) processor technology, (b) evolving wireless networks of the next generation, (c) the intelligent Internet, and (d) the motivation that drives individuals and corporations. In unison, the technological forces can tear human lives apart for the passive or provide a cohesive set of opportunities for the knowledgeable to lead and reap the rewards in the evolved knowledge society. The book also provides in-depth coverage of the functions embedded in modern processors and intelligent communication networks. It focuses on the convergence of the design of modern processor technologies with the switching and routing methodologies of global intelligent networks. Most of the concepts that are generic to the design of terra-flop parallel processors and the terra-bit fiber-optic networks are presented. This book also highlights recent developments in computer and processor technologies into the microscopic and macroscopic medical functions in hospitals and medical centers. Examination of the latest technologies and innovations presented from academic and industrial perspectives of the concurrent dynamic changes in computer and communication industries. An up-to-date and coherent perspective of the developments in the wireless and fiber optic network technologies based on the experience and developments in the older copper, cable and hybrid fiber-coaxial communication systems. Provides a set of novel concepts and methodologies for the innovators in industry -- Source other than Library of Congress.
  • 2005 Springer
    Silverman, Barry G.
    Computerization of clinical guidelines : an application of medical document processing / Gersende Georg -- Case-based medical informatics / Stefan V. Pantazi, José F. Arocha and Jochen R. Moehr -- Analysis and architecture of clinical workflow systems using agent-oriented lifecycle models / James P. Davis and Raphael Blanco -- Virtual communities in health care / George Demiris -- Evidence based telemedicine / George Anogianakis ... [et al.] -- Current status of computerized decision support systems in mammography / G.D. Tourassi -- Medical diagnosis and prognosis based on the DNA microarray technology / Y. Fukuoka, H. Inaoka and I.S. Kohane -- Wearable devices in healthcare / Constantine Glaros and Dimitrios I. Fotiadis.
  • 2001 CRCnetBASE
    Hopgood, Adrian A.
  • 2003 ScienceDirect
    Bouchon-Meunier, B.; Foulloy, L.; Yager, Ronald R.
  • 2001 CRCnetBASE
    Webb, Steve.
  • 2015 Springer
    Komaki, Ritsuko; Nishimura, Yasumasa.
    Successful clinical use of intensity-modulated radiation therapy (IMRT) represents a significant advance in radiation oncology. Because IMRT can deliver high-dose radiation to a target with a reduced dose to the surrounding organs, it can improve the local control rate and reduce toxicities associated with radiation therapy. Since IMRT began being used in the mid-1990s, a large volume of clinical evidence of the advantages of IMRT has been collected. However, treatment planning and quality assurance (QA) of IMRT are complicated and difficult for the clinician and the medical physicist. This book, by authors renowned for their expertise in their fields, provides cumulative clinical evidence and appropriate techniques for IMRT for the clinician and the physicist. Part I deals with the foundations and techniques, history, principles, QA, treatment planning, radiobiology and related aspects of IMRT. Part II covers clinical applications with several case studies, describing contouring and dose distribution with clinical results along with descriptions of indications and a review of clinical evidence for each tumor site. The information presented in this book serves as a valuable resource for the practicing clinician and physicist.
  • 2005 Springer
    Gullo, A.; Lumb, Philip D.
  • 2009 Springer
    Besso, José; Gullo, A.; Lumb, Philip D.; Williams, Ged E.
  • 2008 ClinicalKey
    Hinds, C. J.; Watson, D.
    Planning, organization, and management -- Outcome and costs -- Applied cardiovascular and respiratory physiology -- Assessment and monitoring of cardiovascular function -- Shock, sepsis and multiple-organ failure -- Assessment and monitoring of respiratory function -- Respiratory support -- Respiratory failure -- Myocardial ischaemia, cardiopulmonary resuscitation and management of arrhythmias -- Trauma -- General aspects of managing critically ill patients -- Infection in the critically ill -- Acute renal failure -- Acute liver failure -- Neurological disorders -- Gastrointestinal disorders -- Endocrine emergencies -- Obstetric intensive care -- Poisoning -- Disturbances of body temperature -- Transporting the critically iii.
    Also available: Print – 2008
  • 2005-2010. Springer
  • 2008 Springer
    Vincent, J. L.
  • 2006 Springer
    Fink, M. P. (Mitchell P.), 1948-; Sibbald, William J.; Suter, P. M.
    Also available: Print – 2006
  • 2014 ClinicalKey
    Hanson, C. William; Kohl, Benjamin A.; Lanken, Paul N.; Manaker, Scott.
    Approach to Acute Respiratory Failure -- Approach to Mechanical Ventilation -- Noninvasive Ventilation -- Liberation and Weaning from Mechanical Ventilation and Extubation -- Sedation and Analgesia during Mechanical Ventilation -- Use of Neuromuscular Blocking Agents -- Assessment and Monitoring of Hemodynamic Function -- Cardiogenic Shock and Other Pump Failure States -- Hemorrhagic Shock -- Septic Shock -- Vascular Access Issues and Procedures -- Approach to Supportive Care and Noninvasive Bedside Monitoring -- Management of the Critical Care Patient -- Health Care-Associated Infections -- Nutritional Therapy -- Nutrition-Related Access Procedures -- Pharmacokinetic Alterations in the Critically Ill -- Rational Use of Antimicrobials -- Rational Use of Blood Products -- Renal Replacement Therapy -- Rehabilitation Interventions and Recovery from Critical Illness -- Swallowing and Communication Disorders -- Care of the Patient Infected with Human Immunodeficiency Virus Infection -- Care of the Cancer Patient with Neutropenia or Thrombocytopenia -- Care of the Challenge-to-Wean Patient -- Care of the Patient with End-Stage Renal Disease -- Care of the Patient with End-Stage Liver Disease -- Care of the Maternal-Fetal Unit -- Care of the Patient with Morbid Obesity -- Airways and Emergency Airway Management -- Alcohol Withdrawal: Diagnosis and Management -- Allergies to Antibiotics -- Arrhythmias (Bradycardias) -- Arrhythmias (Tachycardias) -- Barotrauma and Chest Tubes -- Change in Mental Status -- Delirium in the Intensive Care Unit: Diagnosis and Treatment -- Diarrhea Developing in the Intensive Care Unit Patient -- Electrolyte Disorders -- Ileus -- Increased Intracranial Pressure -- Pressure Ulcers: Prevention and Management -- Skin Rashes -- Sleep Disturbances in the Intensive Care Unit -- Thrombocytopenia -- Transfusion Reactions -- Ventilator Alarm Situations -- Weakness Developing in the Intensive Care Unit Patient -- Advanced Cardiac Life Support (ACLS) and Therapeutic Hypothermia -- Chest Pain and Myocardial Ischemia -- Thoracic Aortic Aneurysms and Dissections -- Acute Heart Failure Syndromes -- Hypertensive Crisis and Management of Hypertension -- Pericardial Tamponade -- Hypothermia and Hyperthermia -- Smoke Inhalation and Carbon Monoxide Poisoning -- Drug Overdoses and Toxic Ingestions -- Acute Pancreatitis -- Acute Liver Failure -- Lower Gastrointestinal Bleeding and Colitis -- Upper Gastrointestinal Bleeding -- Hemolytic Anemia -- Idiopathic and Thrombotic Thrombocytopenias -- Acute Central Nervous System Infections -- Community-Acquired Pneumonia -- Necrotizing Fasciitis and Related Soft Tissue Infections -- Acute Neuromuscular Weakness -- Brain Death and Management of Potential Organ Donors -- Neurologic Assessment and Prognosis after Cardiopulmonary Arrest -- Status Epilepticus -- Stroke -- Obstetric and Postobstetric Complications -- Acute Lung Injury and Acute Respiratory Distress Syndrome -- Alternative Modes of Ventilation in Acute Lung Injury -- Acute Respiratory Failure Due to Asthma -- Acute Respiratory Failure Due to Chronic Obstructive Pulmonary Disease -- Deep Venous Thrombosis and Pulmonary Embolism -- Diffuse Alveolar Hemorrhage -- Massive Hemoptysis -- Obesity Hypoventilation Syndrome and Other Sleep-Related Breathing Disorders -- Acute Kidney Injury and Rhabdomyolysis -- Diabetic Ketoacidosis, Hyperglycemic Hyperosmolar State, and Alcoholic Ketoacidosis -- Metabolic Acidoses and Alkaloses -- Disorders of Water Homeostasis: Hyponatremia and Hypernatremia -- Thyroid and Adrenal Disorders in the Intensive Care Unit -- Perioperative Approach to the High-Risk Surgical Patient -- Management of Postoperative and Other Acute Pain -- Cardiac Surgery -- Craniotomy -- Major Abdominal Surgery: Postoperative Considerations -- Major Tissue Flaps -- Major Vascular Procedures -- Perioperative Care of the Morbidly Obese Patient -- Thoracic Surgical Patient -- Approach to the Trauma Patient -- Critical Care for the Orthopedic Patient -- Abdominal Trauma -- Extremity and Major Vascular Trauma -- Head Trauma -- Thoracic Trauma -- Spinal Injury -- Ethical Principles, Communication, and End-of-Life Care -- Teamwork and Collaborative Practice in the Intensive Care Unit -- Family-Centered Care and Communication with Families of Intensive Care Unit Patients -- Providing Culturally Competent Care -- Sleep Deprivation and Sleepiness in Medical Housestaff and Appropriate Countermeasures -- Medical Errors and Patient Safety -- Medical Malpractice, Risk Management, and Chart Documentation -- Long-Term Acute Care in the Spectrum of Critical Care Medicine -- Rapid Response Systems: Rapid Response Teams and Medical Emergency Teams -- Telemedicine Applied to the Intensive Care Unit -- Transporting the Intensive Care Unit Patient.
  • 2007 Springer
    Malva, João O.
  • 2014 Springer
    Klink, Magdalena.
    The tumor environment is a dynamic network that includes cancer cells, immune cells, fibroblasts, endothelial cells, extracellular matrix, cytokines and receptors. The aim of this book is to summarize the role of these components, especially immune cells, in tumor suppression and/or progression and describe in detail why tumor cells can survive and spread in spite of the antitumor response of immune cells. Since immunotherapy is an attractive approach to cancer therapy, this book also provides information on the two main strategies: monoclonal antibodies and adaptive T cell immunotherapy, with a focus on recent human clinical trials. The book provides a state-of-the-art, comprehensive overview of immune cells in cancer and is an indispensable resource for scientists and medical doctors working and/or lecturing in the field of cancer research and immunology.
  • 2006/2007
    Fouts, Ashley E.
    PrintStatus: Not Checked OutLane Catalog Record
  • 2012 Springer
    Hall, Gerri S.
    Antifungal agents -- Antifungal susceptibility testing: Clinical Laboratory and Standards Institute (CLSI) methods -- Antifungal susceptibility testing methods: non-CLSI methods for yeast and moulds -- Susceptibility testing of dermatophytes -- Usual susceptibility patterns of common yeasts -- Usual susceptibility patterns of common moulds and systemic fungi -- Usual susceptibility patterns for systemic dimorphic fungi -- Utility of antifungal susceptibility testing and clinical correlations.
  • 2008
    Rimmerman, Curtis M.; Jain, Anil K.
    PrintStatus: Not Checked OutLane Catalog Record
  • 2014 CRCnetBASE
    Pessione, Enrica.
    "This book underlines the importance of reciprocal interactions between probiotics and humans in terms of stress induction, epigenetic control of cellular responses, oxidative status, bio-active molecules biosynthesis, moonlighting proteins secretion, endogenous toxins neutralization, and several other biological functions. It explores how these responses can affect metabolism and metabolic-related disorders, gutbrain axis balance, mood, inflammatory, allergic and anti-infective reactions, cancer, and ageing. The book explores how probiotics create a dynamic and "fluid" network of signals able to control the balance between healthy and altered human status"--Provided by publisher.
  • 2011 ClinicalKey
    Bradshaw, Ralph A.; Dennis, Edward A.
    "Cell signaling, which is also often referred to as signal transduction or, in more specialized cases, transmembrane signaling, is the process by which cells communicate with their environment and respond temporally to external cues that they sense there. All cells have the capacity to achieve this to some degree, albeit with a wide variation in purpose, mechanism, and response. At the same time, there is a remarkable degree of similarity over quite a range of species, particularly in the eukaryotic kingdom, and comparative physiology has been a useful tool in the development of this field. The central importance of this general phenomenon (sensing of external stimuli by cells) has been appreciated for a long time, but it has truly become a dominant part of cell and molecular biology research in the past three decades, in part because a description of the dynamic responses of cells to external stimuli is, in essence, a description of the life process itself. This approach lies at the core of the developing fields of proteomics and metabolomics, and its importance to human and animal health is already plainly evident"--Provided by publisher.
  • 2013 Springer
    Groschner, Klaus; Wakabayashi, Ichiro.
    This book provides an introduction to the principles of both cardiovascular epidemiology and molecular pathophysiology; as a unique aspect, it also outlines and discusses the molecular concepts underlying epidemiological observations. This first volume is focused on the genetic and molecular basis of pathogenesis and the role of environmental factors triggering cardiovascular dysfunctions. The book promotes the use of interdisciplinary approaches in the field of preventive medicine based on recent advances in molecular and cellular pathophysiology. The book offers a valuable resource work for researchers in basic biomedical fields and clinical scientists alike, as well as guidelines for novel avenues of research in both basic pathophysiology and cardiovascular therapy and prevention.
  • 2013 Springer
    Groschner, Klaus; Wakabayashi, Ichiro.
    This book provides an introduction to the principles of both cardiovascular epidemiology and molecular pathophysiology; as a unique aspect, it also outlines and discusses the molecular concepts underlying epidemiological observations.
  • 2014 Springer
    Groschner, Klaus; Wakabayashi, Ichiro.
    This book provides an introduction to the principles of both cardiovascular epidemiology and molecular pathophysiology; as a unique aspect, it also outlines and discusses the molecular concepts underlying epidemiological observations. This third volume is focused on the most common cardiovascular events to provide an overview on pathogenesis and clinical aspects. The book promotes the use of interdisciplinary approaches in the field of preventive medicine based on recent advances in molecular and cellular pathophysiology. The book offers a valuable resourcefor researchers in basic biomedical fields and clinical scientists alike, as well as guidelines for novel avenues of research in both basic pathophysiology and cardiovascular therapy and prevention.
  • 2001 CRCnetBASE
    Hooker, Neal H.; Murano, E. A.
  • 2005 Springer
    Christakos, George.
    Toward an interdisciplinary methodology -- Stochastic modelling -- Black Death: the background -- Mathematical formulation of the knowledge bases -- Spatiotemporal mapping of the epidemic -- Epea pteroenta.
  • 2011
    Lin, Der-Song; Howe, Roger T.; Kenny, Thomas W.; Khuri-Yakub, Butrus T.
    Capacitive micromachined ultrasonic transducers (CMUTs), have been widely studied in academia and industry over the last decade. CMUTs provide many benefits over traditional piezoelectric transducers including improvement in performance through wide bandwidth, and ease of electronics integration, with the potential to batch fabricate very large 2D arrays with low-cost and high-yield. Though many aspects of CMUT technology have been studied over the years, packaging the CMUT into a fully practical system has not been thoroughly explored. Two important interfaces of packaging that this thesis explores are device encapsulation (the interface between CMUTs and patients) and full electronic integration of large scale 2D arrays (the interface between CMUTs and electronics). In the first part of the work, I investigate the requirements for the CMUT encapsulation. For medical usage, encapsulation is needed to electrically insulate the device, mechanically protect the device, and maintain transducer performance, especially the access of the ultrasound energy. While hermetic sealing can protect many other MEMS devices, CMUTs require mechanical interaction to a fluid, which makes fulfilling the previous criterion very challenging. The proposed solution is to use a viscoelastic material with the glass-transition-temperature lower than room temperature, such as Polydimethylsiloxane (PDMS), to preserve the CMUT static and dynamic performance. Experimental implementation of the encapsulated imaging CMUT arrays shows the device performance was maintained; 95 % of efficiency, 85% of the maximum output pressure, and 91% of the fractional bandwidth (FBW) can be preserved. A viscoelastic finite element model was also developed and shows the performance effects of the coating can be accurately predicted. Four designs, providing acoustic crosstalk suppression, flexible substrate, lens focusing, and blood flow monitoring using PDMS layer were also demonstrated. The second part of the work, presents contributions towards the electronic integration and packaging of large-area 2-D arrays. A very large 2D array is appealing for it can enable advanced novel imaging applications, such as a reconfigurable array, and a compression plate for breast cancer screening. With these goals in mind, I developed the first large-scale fully populated and integrated 2D CMUTs array with 32 by 192 elements. In this study, I demonstrate a flexible and reliable integration approach by successfully combining a simple UBM preparation technique and a CMUTs-interposer-ASICs sandwich design. The results show high shear strength of the UBM (26.5 g), 100% yield of the interconnections, and excellent CMUT resonance uniformity ([lowercase Sigma] = 0.02 MHz). As demonstrated, this allows for a large-scale assembly of a tile-able array by using an interposer. Interface engineering is crucial towards the development of CMUTs into a practical ultrasound system. With the advances in encapsulation technique with a viscoelastic polymer and the combination of the UBM technique to the TSV fabrication for electronics integration, a fully integrated CMUT system can be realized.
  • 2012 Springer
    Sasaki, Keiichi; Stashenko, P.; Suzuki, O.; Takahashi, Nobuhiro.
  • 2015 Springer
    Sasaki, Keiichi; Suzuki, O.; Takahashi, Nobuhiro.
    The Tohoku University Graduate School of Dentistry first introduced the concept of ℓ́ℓInterface Oral Health Scienceℓ́ℓ, designed to establish and maintain healthy oral cavities, which are home to a number of mixed systems. Included in those systems are: (1) host tissues such as teeth, mucosa, muscle and bone, (2) parasites and microorganisms cohabiting the surfaces of the oral cavity, and (3) biomaterials that are used for the rehabilitation of oral functions. In addition, (4) these systems are subject to severe and complex mechanical forces. Therefore, it is critical to promote dental studies that integrate a wide range of interdisciplinary research as medicine, agriculture, material science, engineering, and pharmacology. With this incentive, international symposiums for interface oral health science have been held several times in the past. The concept has since refined and expanded, the result being the ℓ́ℓBiosis-Abiosis Intelligent Interface,ℓ́ℓ and projects aiming at the creation of highly functional and autonomic intelligent interfaces are ongoing. This book brings together a number of studies on incentives and projects by leading authors. Topics include biosis-abiosis interface of dental implants, biomaterials in interface science, biomedical engineering interface, and cell manipulation and tissue regeneration. Readers not only from the field of dentistry but also many related areas will find this book a valuable resource.
  • 2010 Springer
    Sasano, T.; Stashenko, P.; Suzuki, O.
  • 2007 Springer
    Pitha, Paula M.
    Also available: Print – 2007
  • 2005 Springer Protocols
    Carr, Daniel J. J.
    Also available: Print – 2005
  • ScienceDirect
    Pestka, Sidney.
    Also available: Print – 1981
  • ScienceDirect
    Pestka, Sidney.
    Also available: Print – 1981
  • ScienceDirect
    Pestka, Sidney.
    Also available: Print – 1986
  • 2014 Springer
    Fillatreau, Simon; O'Gara, Anne.
    " This volume provides a set of reviews dedicated to the biology of Interleukin (IL)-10. It includes chapters on its importance for maintaining immune homeostasis in humans, its role in intestinal immunity and its functions during viral and bacterial infections. In addition, it presents reviews on the mechanisms linking innate microbial recognition to the production of IL-10 and on how IL-10 recognition by its receptor functions. The roles of T and B cells as relevant sources of IL-10 are also discussed, with an emphasis on the clinical opportunities offered by IL-10-producing Tr1 cells for the suppression of unwanted immunity. Finally, the functions of other cytokines of the IL-10 family are presented. Collectively, these articles provide a comprehensive overview of our current knowledge on one of the most important anti-inflammatory cytokines known to date."--Publisher's website.
  • 2008
    Bledsoe, Bryan E.; Cherry, Richard A.; Porter, Robert S.; Snyder, Scott R.
    PrintStatus: Not Checked OutLane Catalog Record
  • 2006 Springer
    Paramio, Jesús M.
    Desmin and other intermediate filaments in normal and diseased muscle / Denise Paulin and Zhigang Xue -- Intermediate filaments in astrocytes in health and disease / Milos Pekny and Ulrika Wilhelmsson -- Neuronal intermediate filaments and neurodegenerative diseases / Gee Y. Ching and Ronald K.H. Liem -- Neurofilaments: phosphorylation and signal transduction / Sashi Kesavapany, Richard H. Quarles and Harish C. Pant -- Keratin intermediate filaments and diseases of the skin / E. Birgitte Lane -- The keratin K6 minifamily of genes / Manuel Navarro -- Transcriptional regulation of keratin gene expression / Miroslav Blumenberg -- Simple epithelial keratins: expression, function and disease / M. Llanos Casanova, Ana Bravo and José L. Jorcano -- Keratins as targets in and modulators of liver diseases / Kurt Zatloukal ... [et al.] -- The search for specific keratin functions: the case of keratin K10 / Mirentxu Santos ... [et al.].
  • 2006 ProQuest Safari
    Schwartz, Randal L.; Foy, Brian D.; Phoenix, Tom.
    Also available: Print – 2006
  • 2006
    Enderle, John D.; Farden, David Charles; Krause, Daniel J.
  • 2002 HighWire
    Brevetti, G.
    Also available: Print – 2002
  • 2012 Springer
    Serebrovskaya, Tatiana V.; Xi, Lei.
    Part 1. Intermittent Hypoxia and Cardiovascular Disorders -- Sleep-Disordered Breathing and Cardiac Arrhythmias: Role of Intermittent Hypoxia / Thomas Bitter -- Effects of Chronic Intermittent Hypoxia on Cardiac Rhythm Transcriptomic Networks / Sanda Iacobas and Dumitru Andrei Iacobas -- Intermittent Hypoxia and Atherosclerosis / Demet Tekin, Elisa Chong and Lei Xi -- Protective Effects of Chronic Intermittent Hypoxia Against Myocardial Ischemia/Reperfusion Injury / Huang-Tian Yang, Yi Zhang, Zhi-Hua Wang and Zhao-Nian Zhou -- Role of Mitochondrial Permeability Transition Pore in Intermittent Hypoxia-Induced Cardiac and Neuronal Protection / Galina Vavilova, Tatyana Shimanskaya, Nataliya Strutynska, Sergey Talanov and Vadim Sagach -- Intermittent Hypoxia Alters the Function of Cardiovascular Neurons and Reflex Pathways in the Brainstem / David D. Kline and David Mendelowitz. Part 2. Intermittent Hypoxia and Respiratory Disorders -- Effect of Intermittent Hypoxia on Breathing Stability in Individuals with Sleep Apnea / Jason H. Mateika -- Activation of Inflammatory Circulating Factors by Intermittent Hypoxia in Sleep Apnea Syndrome / Larissa Dyugovskaya and Andrey Polyakov -- Beneficial Effects of Intermittent Normobaric Hypoxic Training on Respiratory Function in Patients with Chronic Pulmonary Diseases / Mikhail I. Levashov -- Effects of Intermittent Hypoxic Training on Exercise Tolerance in Patients with Chronic Obstructive Pulmonary Disease / Martin Burtscher -- Intermittent Hypoxia in Treatment of Bronchial Asthma in Childhood / Tatiana V. Serebrovskaya, Alexander N. Bakunovsky, Klaudia V. Nesvitailova and Iryna N. Mankovska. Part 3. Intermittent Hypoxia and Neurological Disorders -- Intermittent Hypoxia and Experimental Parkinson's Disease / Maria V. Belikova, Evgenia E. Kolesnikova and Tatiana V. Serebrovskaya -- Protective Effects of Adaptation to Hypoxia in Experimental Alzheimer's Disease / Eugenia B. Manukhina, Anna V. Goryacheva, Maya G. Pshennikova, Igor Yu. Malyshev and Robert T. Mallet, et al. -- Neuroprotective Mechanisms of Intermittent Hypoxia: An In Vitro Study / Galina Skibo, Maxim Orlovsky, Anastasiia Maistrenko, Victor Dosenko and Iryna Lushnikova. Part 4. Intermittent Hypoxia and Occupational, Environmental, and Other Disorders -- Intermittent Hypoxic Training to Enhance Endurance in Elite Swimmers / Nikolai I. Volkov -- Adaptation to Intermittent Hypoxia/Hyperoxia Enhances Efficiency of Exercise Training / Tatyana G. Sazontova, Antonina V. Bolotova, Irina V. Bedareva, Nadezhda V. Kostina and Yuriy V. Arkhipenko -- Hypobaric Interval Hypoxia as a Nonmedication Method for Improving the Functional State of Aerospace Pilots and Astronauts / Igor B. Ushakov, Anatoli A. Shishov, Vladimir N. Komarevtsev and Vladimir N. Filatov -- Intermittent Hypoxia Remedies Male Subfertility / R. James Swanson and Zoya Serebrovska -- Anticancer Effects of Intermittent Hypoxia in Acute Myeloid Leukemia / Guo-Qiang Chen and Wei Liu -- Energotropic Effects of Intermittent Hypoxia: Role of Succinate-Dependent Signaling / Ludmila D. Lukyanova, Yu I. Kirova and Elina L. Germanova -- Intermittent Hypoxia and Health: From Evolutionary Aspects to Mitochondria Rejuvenation / Arkadi F. Prokopov. Part 5. Methods and Equipment for Therapeutic use of Intermittent Hypoxia in Humans -- Benefits and Risks of Different Regimen of Intermittent Hypoxic Training / Katerina Rozova, Olga Gonchar and Iryna N. Mankovska -- Individualized Intermittent Hypoxia Training: Principles and Practices / Tatiana V. Serebrovskaya and Lei Xi -- Hypoxicators: Review of the Operating Principles and Constructions / Viktor A. Lopata and Tatiana V. Serebrovskaya -- Method of Combined Intermittent Hypoxia and Surface Muscle Electrostimulation for Enhancing Peripheral Stem Cells in Humans / Ginés Viscor, Casimiro Javierre, Teresa Pagès, Luisa Corral and Joan Ramon Torrella, et al.
  • 2007
    Resnick, Donald; Kang, Heung Sik; Pretterklieber, Michael L.
    PrintStatus: Not Checked OutLane Catalog Record
  • 2007 Springer
    Manninger, Jenő.
  • 2010 Springer
    Al-Tubaikh, Jarrah Ali.
  • 2007 Ovid
    Schrier, Robert W.
    Allergy and clinical immunology / Stephen C. Dreskin, Henry N. Claman -- Cardiology / Simon Shakar, Ronald Zolty, JoAnn Lindenfeld -- Endocrinology, metabolism, and diabetes / Irene E. Schauer, Jane E.-B. Reusch -- Gastroenterology / William R. Brown -- Geriatrics / Laurence Robbins -- Infectious diseases / Robert T. Schooley -- Hematology and oncology / Paul Seligman -- Pulmonology / Marvin I. Schwarz -- Nephrology / Tomas Berl, Isaac Teitelbaum -- Rheumatology / Robert W. Janson.
    Also available: Print – 2007
  • 2007
    Alguire, Patrick C.
    PrintStatus: Not Checked OutLane Catalog Record
  • 2009
    Alguire, Patrick C.
    PrintStatus: Not Checked OutLane Catalog Record
  • 2012 Springer
    Saxena, Amol.
    Distal First Metatarsal Osteotomy -- Hallux Valgus: Proximal First Metatarsal Osteotomies -- The Lapidus Procedure -- Hallux Rigidus: The Valenti Arthroplasty -- Hallux Rigidus: Distal First Metatarsal Osteotomy/Hohmann Procedure -- Hallux Rigidus: Proximal Phalangeal Osteotomy/Enclavement Procedure -- Arthrodesis of the First Metatarsophalangeal Joint -- Hallux Rigidus: First Metatarsal Head Resurfacing -- Revision Hallux Valgus Surgery -- Second Metatarsophalangeal Joint Arthropathy -- Tailor's Bunionectomy -- Surgical Treatment of Hammer Toe, Claw Toe, and Mallet Toe Deformity -- Current Techniques of Toenail Surgery -- Forefoot Trauma -- Fractures of the Calcaneus -- Fractures of the Talus -- Percutaneous Plating of Ankle Fractures -- Ankle Instability -- Insertional and Midsubstance Achilles Tendinopathy -- Peroneal Tendinopathy -- First Metatarsophalangeal Joint Sesamoidopathy -- Turf Toe Injuries -- Lisfranc's and Midfoot Injuries -- Stress Fractures of the Foot and Ankle in Athletes -- Plantar Fasciitis -- Osteochondral Lesions of the Talus -- Os Trigonum Injuries -- Syndesmosis Injuries -- Acute Repair of Ruptured Foot and Ankle Tendons in Athletic Patients -- Chronic Compartment Syndrome of Leg and Foot -- Pedal Amputations in Diabetes -- Charcot Foot and Ankle Disease -- Rheumatoid Foot Reconstruction -- The Pediatric Foot -- Surgical Treatment of Flexible Flatfoot in Adolescents with Bioabsorbable Implant -- Acquired Adult Flatfoot Deformity -- Cavus Foot -- Advances in Anterior Ankle and Subtalar Arthroscopy -- Posterior Ankle Arthroscopy and Endoscopy -- Endoscopic Gastrocnemius Recession -- The Use of External Fixation in the Lower Extremity -- Intramedullary Nail Fixation for Tibiotalocalcaneal Arthrodesis -- Total Ankle Arthroplasty: The US Experience -- Tumors and Tumor-Like Lesions of the Foot and Ankle: Diagnosis and Treatment -- Postoperative Physical Therapy for Foot and Ankle Surgery.
  • 2006
    Hill, David W.
    PrintStatus: Not Checked OutLane Catalog Record
  • 2006
    Hirsch, Fred R.
    PrintStatus: Not Checked OutLane Catalog Record
    Global epidemiology of lung cancer -- The molecular epidemiology of lung cancer -- Tobacco, lung cancer and tobacco control -- Clinical approaches to smoking cessation -- Pathology of lung preneoplasia -- Lung carcinogenesis: biology -- Proteomic strategies for the early detection of lung cancer -- Sputum cytology and biomarkers -- The role of autofluorescence bronchoscopy in diagnosis of early lung cancer -- The role of endobronchial ultrasound (EBUS) in diagnosis and treatment of centrally located early lung cancer -- Bronchoscopic treatment of early lung cancer lesions -- CT screening for lung cancer -- New directions in spiral CT image processing and computer-aided diagnosis -- Diagnostic workup of screen-detected lesions -- The pathology of screen-detected lesions -- Surgical approaches to screen-detected lesions and tissue acquisition for translational research -- Non-surgical approaches to early-stage non-small-cell lung cancer (NSCLC) -- Economic evaluation of lung cancer screening -- Chemoprevention -- The selection of the optimal target population for spiral CT screening and chemoprevention trials.
  • 2013
    Fritz, April G.
    PrintStatus: Not Checked OutLane Catalog Record
  • Ovid, Click on ICD-9-CM tab under Tools
    2004 Natl Cent Health Stat
    v. 1. Diseases, tabular list -- v. 2. Diseases, alphabetic index.
    Also available: Print – v. 1-2, 1991-
  • 2007
    PrintStatus: Not Checked OutLane Catalog Record
  • 2005 Springer
    Hering, K. G.; Kusaka, Y.; Parker, J. E.
  • NLM
    *Sneath, P. H. A.; Lapage, S. P.; Lessel, E. F.
    Also available: Print – 1992
  • NLM
    *Sneath, P. H. A.; Lapage, S. P.; Lessel, E. F.
    Also available: Print – 1992
  • v. 1, 2006 CRCnetBASE
    Karwowski, Waldemar.
  • 2015 ScienceDirect
    Wright, James D.
    Provides historical, foundational and interdisciplinary information across behavioral and social sciences, including psychiatry. Includes nearly 4000 articles.
  • 2014 Springer
    Cherry, Andrew L.; Dillon, Mary E.
    The rates are on the decline worldwide. But adolescent pregnancies still occur, placing millions of girls each year at risk for medical complications and social isolation, and their babies for severe health problems--especially when prenatal care is inadequate or nonexistent. But as the opportunity for young women and girls increases around the world, adolescent pregnancy will continue to decline. Featuring reports from countries across the developed and developing worlds, the International Handbook of Adolescent Pregnancy analyzes the scope of the problem and the diversity of social and professional responses. Its biological/ecological perspective identifies factors influencing childhood pregnancy, as well as outcomes, challenges, and needs of very young mothers as they differ across nations and regions. Salient comparisons are made as cultural contexts and community support vary widely, and attention is paid to issues such as child marriage, LGBT concerns, and the impact of religion and politics on health care, particularly access to contraception, abortion, and other services. This global coverage heightens the understanding of readers involved in care, education, and prevention programs, and otherwise concerned with the psychosocial development, reproductive health, and general well-being of girls.
  • 2012 Springer
    Potegal, Michael; Spielberger, Charles Donald; Stemmler, Gerhard.
    Cross-disciplinary views of anger : consensus and controversy / Michael Potegal and Gerhard Stemmler -- A brief history of anger / Michael Potegal and Raymond W. Novaco -- Population and molecular genetics of anger and aggression : current state of the art / Martin Rueter -- Constructing a neurology of anger / Michael Potegal and Gerhard Stemmler -- Anger, motivation, and asymmetrical frontal cortical activations / Eddie Harmon-Jones, Carly K. Peter