• 2015From: Springer
    Norbert Müller, Aye-Mu Myint, Markus J. Schwarz, editors.
    Psychiatric disorders are one of the most dramatic burdens for humankind. The role of immune dysfunction in the pathophysiology of these disorders has emerged during the last years, because there has been tremendous progress in psychoneuroimmunological research. Many results are presented here by pioneers in the field. The book addresses various effects of the immune system on the pathophysiology and course of psychiatric disorders and highlights the possible future impact on treatment decisions of various psychiatric disorders, including schizophrenia and depression. The contributions cover the role of in utero immune challenges on the development of schizophrenia, the role of infections, and autoimmune diseases and mild immune activation in the development of depression and schizophrenia, the influence of immune responses in other disorders such as Tourette's, Alzheimer's, and OCD, the connections between mental and physical pain as well as between anti-inflammatory and antipsychotic drugs.
  • Mary Louise Turgeon.
    PrintStatus: Not Checked OutLane Catalog Record
  • J.H.L. Playfair, B.M. Chain.
    PrintStatus: Not Checked OutLane Catalog Record
  • 2017From: ClinicalKey
    Matthew Helbert.
    1. Introduction to the immune system -- 2. Basic concepts and components of the immune system -- 3. Introduction to the antigen recognition -- 4. Antigens and antibody structure -- 5. Antibody-antigen interaction -- 6. Antibody diversity -- 7. The T-cell receptor -- 8. Major histocompatibility complex -- 9. Review of antigen recognition -- 10. Antigen processing and presentation -- 11. Lymphocyte activation -- 12. Hematopoiesis -- 13. Organs and tissues of the immune system -- 14. B-cell development -- 15. T-cell development -- 16. T-cell interactions and T=cell help -- 17. Immunologic memory and homeostasis -- 18. Regulation of the immune system -- 19. Brief review of immune physiology -- 20. Constitutive defense including complement -- 21. Phagocytes -- 22. Killing in the immune system -- 23. Inflammation -- 24. Cytokines in the immune system -- 25. Infections and vaccines -- 26. Hypersensitivity reactions -- 27. Immediate hypersensitivity (Type I): allergy -- 28. How autoimmune disease develops -- 29. Antibody-mediated hypersensitivity (Type II) -- 30. Immune complex disease (Type III hypersensitivity ) -- 31. Delayed hypersensitivity (Type IV) and review of hypersensitivity reactions -- 32. Primary immunodeficiency -- 33. Primary immunodeficiency -- 33. Secondary immunodeficiency -- 34. Transplantation -- 35. Tumor immunology -- 36. Biopharmaceuticals.
  • 2012From: ScienceDirect
    Dennis K. Flaherty.
    With a new pharmacy-specific approach to immunology, Immunology for Pharmacy prepares pharmacists for practice by providing a complete understanding of the basis of immunology and the consequences of either suppressing or enhancing immune function. It covers key subjects such as prophylaxis and vaccination, antibodies as therapeutic and diagnostic agents, biological modifiers, and the rationale for use and mechanisms of therapeutic agents. Written by experienced author and educator Dennis Flaherty, this book presents topics with a logical, step-by-step approach, explaining concepts and their practical application. A companion Evolve website reinforces your understanding with flashcards and animations. Pharmacy-specific coverage narrows the broad field of immunology to those areas most pertinent and clinically relevant to pharmacy students. 165 full-color illustrations help to illuminate difficult concepts. Factors That Influence the Immune Response chapter covers biological agents including bacteria, viruses, and fungi, and their related toxins and how they relate to the immune system. Three chapters on vaccinations prepare you for this important part of the pharmacist's role by discussing cancer treatment with whole tumor vaccines, cell vaccines, and viral vector vaccines, describing other vaccines such as recombinant vaccines and plant vaccines, and examining how diseases such as diphtheria, whooping cough, and tetanus respond to vaccinations. A summary of drugs used in treating each condition helps you understand typical treatments and their immunological mechanisms, so you can choose proper treatments. Integrated information makes it easier to understand how various parts of the immune system work together, leading to a better understanding of immunology as a whole. A unique focus on practical application and critical thinking shows the interrelationship of concepts and makes it easier to apply theory to practice. Information on AIDS covers the identification and treatment of both strains of HIV as well as AIDS, preparing you for diseases you will see in practice. Unique student-friendly features simplify your study with learning objectives and key terms at the beginning of each chapter, bulleted summaries and self-assessment questions at the end of each chapter, and a glossary at the back of the book. Over 60 tables summarize and provide quick reference to important material. A companion Evolve website includes animations and pharmacy terminology flashcards.
  • 2014From: Springer
    Ahmad Massoud, Nima Rezaei, editors.
    An Introduction on the old age and aging of the immune system -- The immune system, a marker and modulator of the rate of aging -- Age-associated alterations of pleiotropic stem cell and the therapeutic implication of stem cell therapy in aging -- A role for epigenetic modulation of the innate immune response during aging -- Basophil, eosinophil and neutrophil functions in the elderly -- Dendritic cells and dysregulated immunity in the elderly -- Natural killer cell immunosenescence and cancer in the elderly -- Pattern recognition receptors and aging -- Impact of ageing on T cell repertoire and immunity -- T cell mediated immunity in the immunosenescence process -- Biological and phenotypic alterations of T cells in aging -- T cells seen from the metabolic and aging perspective -- Age-related alterations in regulatory T cells -- Effects of aging on B cells -- The role of MicroRNAs in immunosenescence process -- Immunogenetics of Aging -- Aging immunity and infection -- Influenza infection in the elderly -- Optimising response to vaccination in the elderly -- Nutrition, immunity and aging -- Diet and immunosenescence -- Dietary Intake and impact of zinc supplementation on the immune functions in elderly: nutrigenomic approach -- Physiological and pathological role of reactive oxygen species in the immune cells -- Oxidative stress in aging -- Skin aging and the immune system -- Aging immunity and the impact of physical exercise.
  • 2007From: Springer
    edited by Gordon D. Brown and Mihai G. Netea.
  • 2005From: Karger
    volume editor, Udo R. Markert.
    Also available: Print – 2005
  • 2010From: ScienceDirect
    edited by Dieter Kabelitz and Stefan H.E. Kaufmann.
    1. The Immune Response to Infectious Agents / Stefan H.E. Kaufmann, Dieter Kabelitz -- 2. Immunomagnetic Isolation of Subcellular Compartments / Vladimir Tchikov, Jürgen Fritsch, Dieter Kabelitz, Stefan Schütze -- 3. Use of Bioinformatics to Predict MHC Ligands and T-Cell Epitopes: Application to Epitope-Driven Vaccine Design / Anne S. De Groot, Tobias Cohen, Matthew Ardito, Lenny Moise, Bill Martin, Jay A. Berzofsky -- 4. Genetics of Susceptibility and Resistance to Infection / Aurelie Cobat, Marianna Orlova, Alexandre Alcaїs, Erwin Schurr -- 5. Proteomic Approaches to Study Immunity in Infection / Gustavo Souza, Harald G. Wiker -- 6. Isolation and Characterization of Human Epithelial Antimicrobial Peptides and Proteins / Jens.-M. Schröder -- 7. Visualization and Functional Evaluation of Phagocyte Extracellular Traps / Maren von Köckritz-Blickwede, Ohn Chow, Mariam Ghochani, Victor Nizet -- 8. Killer Cell Assays / Patricia Graef, Veit R. Buchholz, Dirk H. Busch -- 9. Analysis of Intestinal T Cell Populations and Cytokine Productions / Jun Kunisawa, Hiroshi Kiyono -- 10. Isolation and Measuring the Function of Professional Phagocytes: Murine Macrophages / Leanne Peiser, Subhankar Mukhopadhyay, Richard Haworth, Siamon Gordon -- 11. Measuring Immune Responses In Vivo / Stefan Ehlers, Norbert Reiling, Christoph Hölscher, Sahar Aly -- 12. Murine and Guinea Pig Models of Tuberculosis / Diane J. Ordway, lan M. Orme -- 13. The Leishmaniasis Model / Pascale Kropf, Ulrich D. Kadolsky, Matthew Rogers, Thomas E. Cloke, Ingrid Müller -- 14. Animal Models of Mucosal Candida Infections / Flavia De Bernardis, Silvia Arancia, Silvia Sandini -- 15. Mucosal Immunity and Inflammation / Ulrich Steinhoff, Alexander Visekruna -- 16. CD8 T-Cell Immunotherapy of Cytomegalovirus Disease in the Murine Model / Niels A.W. Lemmermann, Jürgen Podlech, Christof K. Seckert, Kai A. Kropp, Natascha K.A. Grzimek, Matthias J. Reddehase, Rafaela Holtappels -- 17. Measuring Immune Responses In Situ: Immunofluorescent and Immunoenzymatic Techniques / Antje Müller, Torsten Goldmann, Ulrike Seitzer -- 18. Measuring Human Cytokine Responses / Hans Yssel, John Wijdenes, René de Waal Malefyt, Jean-François Mathieu, Jérôme Pène -- 19. Human Dendritic Cell Subsets / Hideki Ueno, Eynav Klechevsky, A. Karolina Palucka, Jacques Banchereau.
  • 2005From: Karger
    volume editor: Udo R. Markert.
    Also available: Print – 2005
  • 2006From: Springer
    [edited by] Gil Mor.
    Evolution of the mammalian reproductive tract and placentation / Susan Richman and Frederick Naftolin -- Toll-like receptors and pregnancy / Vikki M. Abrahams and Gil Mor -- IL-10 and pregnancy / Shaun P. Murphy and Surendra Sharma -- Th1/Th2 balance of the implantation site in humans / Shigeru Saito, Satomi Miyazaki, and Yasushi Sasaki -- The regulation of human trophoblast apoptosis and survival during pregnancy / Shawn L. Straszewski-Chavez and Gil Mor -- Macrophages and pregnancy / Gil Mor, Roberto Romero, and Vikki M. Abrahams -- Potential role of glucocorticoids in the pathophysiology of intrauterine growth restriction (IUGR) / Seth Guller, Yuehong Ma, and Men-Jean Lee -- NK cells and pregnancy / Mikael Eriksson, Satarupa Basu, and Charles L. Sentman -- The role of corticotropin-releasing hormone (CRH) on implantation and immunotolerance of the fetus / Sophia N. Kalantaridou ... [et al.] -- Indoleamine 2,3 dioxygenase-dependent T cell suppression and pregnancy / Babak Baban, Phillip R. Chandler, and Andrew L. Mellor -- Leukemia inhibitory factor in reproduction / Levent M. Senturk and Aydin Arici -- Characterization of human dendritic cells at the materno-fetal interface / Ulrike Kämmerer ... [et al.] -- MHC molecules of the preimplantation embryo and trophoblast / Martina Comiskey, Carol M. Warner, and Danny J. Schust -- Actions of seminal plasma cytokines in priming female reproductive tract receptivity for embryo implantation / Sarah A. Robertson ... [et al.] -- B7 family molecules in the placenta / Margaret G. Petroff -- The role of regulatory T cells in materno-fetal tolerance / Varuna R. Aluvihare and Alexander G. Betz -- The eutherian fetoembryonic defense system hypothesis: an update / Gary F. Clark ... [et al.] -- The nature and role of the decidual T cells / Lucia Mincheva-Nilsson and Vladimir Baranov -- Trophoblast cells as immune regulators / Gil Mor and Vikki M. Abrahams -- Inherited thrombophilias and early pregnancy loss / Jens Langhoff-Roos ... [et al.] -- Bi-directional cell trafficking during pregnancy: long-term consequences for human health / Kristina M. Adams and J. Lee Nelson -- Term and preterm parturition / Roberto Romero ... [et al.] -- Interleukin-1 and implantation / Jan-S. Krüssel ... [et al.] -- Immunology and pregnancy losses: HLA, autoantibodies and cellular immunity / Joanne Kwak-Kim, Joon Woo Kim, and Alice Gilman-Sachs.
  • 2014From: Springer
    Ernst Rainer Weissenbacher.
    Fundamentals of immunology: Concepts of innate and specific immunity -- Mucosal immunology -- General immunology of the genital tract: Distinct features of the genital mucosal tissue -- Functions and regulation of innate immune responses in the human reproductive tract -- Functions and regulation of adaptive humoral and cell-mediated immunity in the female genital tract -- Immunization studies -- Immunology of menstruation {u2013} menstruation as an inflammatory process -- Immunology of genital tract infections: Viral infections of the genital tract -- Bacterial infections of the genital tract -- Candidiasis -- Trichomoniasis -- Immunology in reproductive medicine: Immunology of pregnancy -- Immunologic infertility -- Immunocontraceptive approaches.
  • 2013From: Springer
    Laura Santambrogio, editor.
    Immunology of the Lymphatic System is a comprehensive study of the lymphatic system and its immunological role. It begins with lymphatic capillaries, their origin and development. It addresses lymph circulation, in general, with a special emphasis on lymph circulation in parenchymal organs. The next section focuses on lymph nodes, subcortical circulation and the conduit system. It discusses organs with no lymphatic system, such as the brain. Finally, it covers lymph composition and cells in the lymph. While primarily basic research, the volume touches upon elements of the clinical, as well, broadening its scope and appeal.
  • 2008From: Springer
    Bruce Beutler, editor.
    The forward genetic dissection of afferent innate immunity / B. Beutler and E.M. Moresco -- Genetic analysis of resistance to infections in mice: A/J meets C57BL/6J / J.F. Marquis and P. Gros -- Host defenses against human papillomaviruses: lessons from epidermodysplasia verruciformis / G. Orth -- Innate resistance to flavivirus infections and the functions of 2'-5' oligoadenylate synthetases / T. Mashimo, D. Simon-Chazottes and J.L. Guenet -- Cmv1 and natural killer cell responses to murine cytomegalovirus infection / A.A. Scalzo and W.M. Yokoyama -- Genetic dissection of host resistance to Mycobacterium tuberculosis: the sst1 locus and the Ipr1 gene / I. Kramnik -- Scurfy, the Foxp3 locus, and the molecular basis of peripheral tolerance / M.W. Appleby and F. Ramsdell -- Fevers, genes, and innate immunity / J.G. Ryan and D.L. Kastner -- Itchy mice: the identification of a new pathway for the development of autoimmunity / L.E. Matesic, N.G. Copeland and N.A. Jenkins -- TIM gene family and their role in atopic diseases / D.T. Umetsu ... [et al.].
    Also available: Print – 2008
  • 2013From: ClinicalKey
    David Male [and others].
    This textbook teaches the basic and clinical immunology concepts.
  • 2013From: Springer
    Darren R. Flower, Yvonne Perrie, editors.
    This book seeks to expand the horizons of vaccine design and discovery by highlighting cutting edge work in three areas of vaccinology: the rational discovery of subunit vaccines, the identification of adjuvants, and the delivery of vaccines via state-of-the-art nanotechnology.
  • v. 2-, 2009-From: Springer
  • 2014From: CRCnetBASE
    edited by Bharat B. Aggarwal, David Heber.
    Chapter 1. Evolution of innate and adaptive immunity / David Heber and Bharat B. Aggarwal -- chapter 2. Cellular mechanisms of cytokine activation / David Heber and Bharat B. Aggarwal -- chapter 3. Cellular lipids and inflammation / David Heber and Susanne Henning -- chapter 4. Biomarkers of inflammation and the Western diet / David Heber and Susanne Henning -- chapter 5. Phytochemicals and immune function / David Heber -- chapter 6. Genetic and environmental modifiers of immune function / David Heber -- chapter 7. Cancer and inflammation / David Heber -- chapter 8. Abdominal obesity : pathophysiology and related metabolic complications / Ana F.T.A. Junqueria and Caroline M. Apovian -- chapter 9. Type 2 diabetes and inflammation / Zhaoping Li and David Heber -- chapter 10. Heart disease and inflammation / Kaveh Daniel Navab -- chapter 11. Chronic kidney disease and inflammation / Karl J. Neff and Carel Le Roux -- chapter 12. Alzheimer's disease and inflammation / Stephen T. Chen and Gary W. Small -- chapter 13. Nutrition in autoimmunity : a focus on systemic lupus erythematosus and rheumatoid arthritis / Maureen McMahon -- chapter 14. Asthma and inflammation / Andre Nel and David Heber -- chapter 15. Muscle and immune function / Anthony Thomas and David Heber -- chapter 16. Approaches to reducing abdominal obesity / Zhaoping Li and David Heber -- chapter 17. Barriers to fruit and vegetable consumption and practical strategies for increasing fruit and vegetable intake / Susan Bowerman -- chapter 18. Healthy fats and oils : balancing omega-3 and omega-6 acids in tissues / Bill Lands -- chapter 19. Spices and dietary supplements with anti-inflammatory activity / Bharat B. Aggarwal and David Heber.
  • 2008From: Springer
    Manzoor M. Khan.
  • 2017From: ScienceDirect
    edited by Virgil E.J.C. Schijns (Wageningen University, Wageningen, The Netherlands), Derek T. O'Hagan (GSK Vaccines, Rockville, MD, United States).
  • 2013From: Springer Protocols
    edited by Kelly M. Fulton, Susan M. Twine.
    Introduction to the immune system / Scott McComb ... [et al.] -- Immunoproteomics : current technology and applications / Kelly M. Fulton and Susan M. Twine -- Antigen identification using SEREX / Ugur Sahin and Özlem Türeci -- Antigen discovery using whole-genome phage display libraries / Elisa Beghetto and Nicola Gargano -- Methods and applications of serological proteome analysis / Kelly M. Fulton ... [et al.] -- Pre-absorbed immunoproteomics : a novel method for the detection of bacterial surface proteins / Guangjin Liu, Wei Zhang, and Chengping Lu -- Identification of the antigen content of electroimmunoprecipitates / N. Helena Beyer and Niels H.H. Heegaard -- Immunoproteomics approach to screen the antigenicity of the influenza virus / Kevin M. Downard -- In vivo microbial antigen discovery (InMAD) to identify diagnostic proteins and polysaccharides that are circulating during microbial infections / Sindy J. Chaves ... [et al.] -- Chemo-enzymatic production of O-glycopeptides for the detection of serum glycopeptide antibodies / Alexander Nøstdal and Hans H. Wandall -- Enrichment and characterization of glycopeptide epitopes from complex mixtures / Luc Tessier, Kelly M. Fulton, and Susan M. Twine -- Whole-cell MALDI-TOF mass spectrometry : a tool for immune cell analysis and characterization / Richard Ouedraogo ... [et al.] -- Cell-based arrays for the identification of interacting polypeptide domains or epitopes / Richard H. Maier, Christina J. Maier, and Kamil Önder -- Identification and quantitation of MHC class II-bound peptides from mouse spleen dendritic cells by immunoprecipitation and mass spectrometry analysis / Leonia Bozzacco and Haiqiang Yu -- Construction and screening of an antigen-derived peptide library displayed on yeast cell surface for CD4+ T cell epitope identification / Fei Wen and Huimin Zhao -- Profiling of cytokine and chemokine responses using multiplex bead array technology / Greg Harris and Wangxue Chen -- Preparation of the low molecular weight serum proteome for mass spectrometry analysis / Timothy J. Waybright ... [et al.] -- Identification of protein biomarkers in human serum using iTRAQ and shotgun mass spectrometry / Theodoros A. Koutroukides ... [et al.] -- Genome-based bioinformatic prediction of major histocompatibility complex (MHC) epitopes / Simon J. Foote -- Structure-based prediction of major histocompatibility complex (MHC) epitopes / Andrew J. Bordner -- Prioritization of therapeutic targets of inflammation using proteomics, bioinformatics, and in silico cell-cell interactomics / Arsalan S. Haqqani and Danica B. Stanimirovic -- Commercial considerations for immunoproteomics / Scott M. Ferguson.
  • 2015From: Springer Protocols
    edited by Albert C. Shaw.
    Isolation of lipid rafts from human neutrophils by density gradient centrifugation / Carl Fortin and Tamas Fülöp -- Flow cytometry analysis of NK cell phenotype and function in aging / Raquel Tarazona ... [et al.] -- Flow cytometric identification of fibrocytes in the human circulation / Xinyuan Hu, Erin M. DeBiasi, and Erica L. Herzog -- Experimental approaches to tissue injury and repair in advanced age / Aleah L. Brubaker, Stewart R. Carter, and Elizabeth J. Kovacs -- Multicolor digital flow cytometry in human translational immunology / Samit R. Joshi, Subhasis Mohanty, and Albert C. Shaw -- Flow cytometry-based methods to characterize immune senescence in nonhuman primates / Christine Meyer ... [et al.] -- Multiparameter phenotyping of human PBMCs using mass cytometry / Michael D. Leipold, Evan W. Newell, and Holden T. Maecker -- Imaging immunosenescence / Feng Qian and Ruth R. Montgomery -- Activation-induced cytidine deaminase and switched memory B cells as predictors of effective in vivo responses to the influenza vaccine / Daniela Frasca, Alain Diaz, and Bonnie B. Blomberg -- Analyzing the effect of aging on CD8+ T-cell phenotype using flow cytometry / Min Sun Shin and Insoo Kang -- Cell-mediated immune response to influenza using ex vivo stimulation and assays of cytokine and granzyme B responses / Janet E. McElhaney and Beth Gentleman -- Assays for monitoring macroautophagy activity in T cells / Yair Botbol and Fernando Macian -- Fluorescence-based approaches for quantitative assessment of protein carbonylation, protein disulfides, and protein conformation in biological tissues / Asish R. Chaudhuri ... [et al.] -- Monitoring the DNA damage response at dysfunctional telomeres / Rekha Rai and Sandy Chang -- Single-cell analysis of T-cell receptor Αβ repertoire / Pradyot Dash, George C. Wang, and Paul G. Thomas -- Assessment of B cell repertoire in humans / Yu-Chang Wu, David Kipling, and Deborah Dunn-Walters -- Laboratory and data analysis methods for characterization of human B cell repertoires by high-throughput DNA sequencing / Chen Wang ... [et al.] -- Discovery of novel microRNAs in aging Caenorhabditis elegans / Alexandre de Lencastre and Frank Slack -- Analysis of DNA methylation by pyrosequencing / Colin Delaney, Sanjay K. Garg, and Raymond Yung.
  • 2012From: Springer
    Andreas Thiel, editor.
  • 2013From: Springer
    Jos A. Bosch, Anna C. Phillips, Janet M. Lord, editors ; foreword by Keith W. Kelley.
    This book presents the first multi-disciplinary approach to the understanding of immune aging, or immunosenescence; it combines biological data and clinical observations with psychological, social, and behavioral perspectives and is thus a valuable and timely contribution to the literature in this area. Contributors, all eminent scholars in their respective fields, review thoroughly the state of the art in research that examines how psychological and behavioral factors influence the rate and extent of immune system aging.
  • 2017From: ScienceDirect
    Huangxian Ju, Guosong Lai, Feng Yan.
  • 2012From: Future Med
    editors, Yehuda Shoenfeld, Pier Luigi Meroni, Ricard Cervera.
    Immunotherapeutic agents for SLE / Yehuda Shoenfeld, Pier Luigi Meroni & Ricard Cervera -- Immunopathogenesis of SLE and drug targets / Arvind Kaul, David D'Cruz & Graham R.V. Hughes -- Rituximab in SLE / Cándido Díaz-Lagares, Manuel Ramos-Casals & Munther A. Khamashta -- Belimumab in SLE / Ricard Cervera & Gerard Espinosa -- Epratuzumab in SLE / David M. Goldenberg & Daniel J. Wallace -- Intravenous immunoglobulin therapy for SLE / Ziv Rozman & Gisele Zandman-Goddard -- Other novel immunotherapeutic agents in the pipeline and future directions / Ana M. Bertoli & Graciela S. Alarcón -- Index.
  • 2017From: Springer
    Aung Naing, Joud Hajjar, editors.
    "In the last decade, immunotherapy has revolutionized the practice of medicine in the field of oncology. This book, Immunotherapy, highlights the immunotherapeutic approaches currently in use and strategies to overcome the associated challenges. As comprehensive knowledge of basic immunology in the context of tumor biology is required to move further along the line of development in translational science, this book provides an overview of the cellular components of the immune system that interact with each other to provide a successful immune response. Immunotherapy offers promising antitumor activity across multiple cancer types as it does not attack the tumor but primarily revitalizes a suppressed immune system. It is beyond the scope of this book to discuss the immunotherapeutic approaches across the tumor board. However, the book features the role of immune-oncology in acute myeloid leukemia, non-small cell lung cancer, and sarcomas to showcase the recent advances in the management of cancer broadly classified as hematological malignancies, solid tumors, and tumors arising in the connective tissue. The book also discusses alternative formulations and combinatorial approaches to enhance the therapeutic index of these agents. As immunotherapeutic agents differ significantly from chemotherapeutic agents in response patterns and toxicity profiles, evaluating their safety and efficacy in clinical trials remains a challenge. In this book, we discuss the use of a variety of traditional and new immunotherapy criteria to evaluate response, their inadequacies, and clinical implications. The book also outlines how recent advances in medical imaging technology have the potential to provide high-dimensional data to improve decision support and individualize treatment selection and monitoring. Importantly, the book attempts to increase the awareness to immune related adverse events and the need for aggressive and judicious management of toxicities to improve treatment outcomes in patients on immunotherapy In short, this book provides a broad understanding of immunotherapy and ways to leverage the immune system to make inroads in the fight against cancer"--Publisher's description.
  • 2007From: Springer
    A. Radbruch ... [et al.], editors.
  • 2006From: Springer
    edited by Mary L. Disis.
    Discovery of target molecules for cancer immunotherapy by genetic and bioinformatic approaches -- Current strategies for the identification of immunogenic epitopes of tumor antigens -- Current and future role of natural-killer cells in cancer immunotherapy -- The role of immune monitoring in evaluating cancer immunotherapy -- Statistical analysis of immune response assays -- DNA vaccines for cancer immunotherapy -- Dendritic cells -- Different approaches to dendritic cell-based cancer immunotherapy -- Anti-idiotype antibody vaccines for the immunotherapy of cancer -- Autologous tumor-derived heat shock protein vaccine as a new paradigm for individualized cancer therapeutics -- Tumor-reactive T-cells for adoptive immunotherapy -- T-cell adoptive immunotherapy of cancer: from translational models to clinical significance -- Retroviral-mediated gene transfer for engineering tumor-reactive T-cells -- Harnessing the potential of graft-vs-tumor -- Tumor-induced immune suppression and immune escape: mechanisms and impact on the outcome of immunotherapy of malignant disease -- The tumor microenvironment: regulation of antitumor immunity and implications for immunotherapy -- Manipulation of lymphocyte homeostasis for enhancing antitumor immunity -- Fast-lane evolution in the tumor microenvironment -- Manipulating immunological checkpoints to maximize antitumor immunity -- Interleukin-2 as cancer therapy -- Biological and clinical properties of the type 1 interferons -- Promising g [gamma]-chain cytokines for cancer immunotherapy: interleukins-7, -15, and -21 as vaccine adjuvants, growth factors -- The therapeutic use of natural-killer cells in hematological malignancies -- Antibody therapy for solid tumors -- Antibody therapy for non-Hodgkin's lymphoma -- Approaches to in vivo imaging of cancer immunotherapy -- Design issues for early-stage clinical trials for cancer vaccines -- Monoclonal antibody therapy for cancer.
  • 2015From: ScienceDirect
    edited by Xiang-Yang Wang and Paul B. Fisher.
  • 2016From: Springer
    Yoshiyuki Yamaguchi, editor.
    Part I. Overview, history, classification -- Part II. BRMs and crude agents -- Part III. Adoptive cell therapy -- Part IV. Vaccine therapy -- Part V. Immunoadjuvants -- Part VI. Immunocheckpoints -- Part VII. Regulation of immunosuppression -- Part VIII. Immune-related response criteria and guidance for clinical trials -- Part IX. Personalized immunotherapy.
  • 2010From: Springer Protocols
    edited by Patricia Yotnda.
    Hypoxic tumors and their effect on immune cells and cancer therapy / Patricia Yotnda, Danli Wu, and Anna May Swanson -- Characterization of regulatory T cells in tumor suppressive microenvironments / Guangyong Peng -- Generation of cytotoxic T lymphocytes for immunotherapy of EBV-associated malignancies / Corey Smith and Rajiv Khanna -- Acquisition, preparation, and functional assessment of human NK cells for adoptive immunotherapy / Dean A. Lee, Michael R. Verneris, and Dario Campana -- Enhanced migration of human dendritic cells expressing inducible CD40 / Natalia Lapteva -- Differentiation of human embryonic stem cells into hematopoietic cells in vitro / Eun-Mi Kim and Nicholas Zavazava -- Gene therapy to improve migration of T cells to the tumor site / Antonio Di Stasi, Biagio De Angelis, and Barbara Savoldo -- Gene therapy to improve function of T cells for adoptive immunotherapy / Concetta Quintarelli, Barbara Savoldo, and Gianpietro Dotti -- Cytokine-FC fusion genes as molecular adjuvants for DNA vaccines / Daniel Hirschhorn-Cymerman and Miguel-Angel Perales -- Pharmacology of anti-CD3 diphtheria immunotoxin in CD3 positive T-cell lymphoma trials / Jung Hee Woo ... [et al.] -- Construction of human antibody gene libraries and selection of antibodies by phage display / Thomas Schirrmann and Michael Hust -- Identification of immunogenic peptides of the self-tumor antigen : our experience with telomerase reverse transcriptase / Xochitl Cortez-Gonzalez and Maurizio Zanetti -- Rescue, amplification, purification, and PEGylation of replication defective first-generation adenoviral vectors / Michael A. Barry, Eric A. Weaver, and Sean E. Hofherr -- Adenovirus-mediated interleukin (IL)-24 immunotherapy for cancer / Rajagopal Ramesh ... [et al.] -- Liposomes for gene transfer in cancer therapy / Nancy Smyth Templeton -- Oncolytic HSV as a vector in cancer immunotherapy / Hongtao Li and Xiaoliu Zhang -- Generation of chimeric T-cell receptor transgenes and their efficient transfer in primary mouse T lymphocytes / Linda J. Howland, Nicole M. Haynes, and Phillip K. Darcy -- Multi-walled carbon nanotube (MWCNT) synthesis, preparation, labeling, and functionalization / Babak Kateb ... [et al.] -- Cellular immunotherapy of cancer / Fatma V. Okur and Malcolm K. Brenner.
  • 2012From: Springer
    Rodney R. Dietert, Robert W. Luebke, editors.
    Immunotoxicity, Immune Dysfunction, and Chronic Disease is among the first books to illustrate the linkage between environmental risk factors (e.g., chemicals, drugs, diet, lifestyles), environmentally-induced immune dysfunction and the full range of resulting chronic diseases and conditions. There is a detailed discussion of specific immune-based chronic diseases and conditions that emerge in children and adults and affect different physiological systems. The book integrates a consideration of risk factors and specific immunotoxic alterations with disease outcomes. A significant number of diseases and conditions are discussed, such as systemic allergic diseases affecting the lung, skin and gastrointestinal tract, systemic autoimmune diseases (type 1 diabetes, multiple sclerosis and lupus) and chronic conditions that are not traditionally associated with chemically-mediated immunomodulation (depression, frailty, and atherosclerosis). Inflammatory dysregulation is a common thread that connects many of the diseases and conditions discussed in this book and provides a central focus. Individual chapters are organized by disease with the addition of chapters that provide integrative information on: 1) patterns of disease comorbidities and 2) the safety testing of chemicals and drugs to reduce the risk of immune dysfunction. Each chapter contains a summary of key points as well as recommendations when appropriate. The book stresses the benefits of identifying the environmental risk factors of immune-mediated chronic disease and the potential to reduce the prevalence of these diseases and conditions. This volume is a valuable resource for researchers, clinicians, risk assessors and regulators and students.
  • 2007From: CRCnetBASE
    edited by Robert Luebke, Robert House, and Ian Kim.
  • v.1, 2004From: ScienceDirect
    J. Descotes.
    v. 1. Principles and methods of immunotoxicology.
  • 2014From: Springer
    Deborah J. Bowen, Gerald V. Denis, Nathan A. Berger, editors.
    Obesity and Cancer in Appalachia -- Disparities in Cancer Outcomes A UK Perspective -- Behavioral Differences Leading to Disparities in Energy Balance and Cancer -- Impact of obesity, race, and ethnicity on cancer survivorship -- The biology of aging: Role in cancer, metabolic dysfunction and health disparities -- Energy Balance and Multiple Myeloma in African Americans -- Single Nucleotide Polymorphisms in Obesity and Inflammatory Genes in African Americans with Colorectal Cancer -- Ethnic Differences in Insulin Resistance as a mediator of Cancer Disparities -- Role of ethnic differences in mediators of energy balance -- Community-Based Strategies to Alter Energy Balance in Underserved Breast Cancer Survivors -- The role of policy in reducing inflammation -- Cancer Prevention through Policy Interventions that Alter Childhood Disparities in Energy.
  • 2013From: Springer
    Wafik S. El-Deiry, editor.
    Novel antineoplastics targeting genetic changes in colorectal cancer / Jamal Joudeh...[et al.] -- Update on clinical trials: genetic targets in breast cancer / Bora Lim, Leah V. Cream, Harold A. Harvey -- Impace of genetic targets on cancer therapy in esophagogastric cancer / Yixing Jiang -- Impact of genetic targets on cancer therapy: hapatocellular cancer / Osama Hamed...[et al.] -- Toward the goal of personalizaed therapy in pancreatic cancer by targeting the molecular phenotype / Nelson S. Yee -- Impact of genetic markers on treatment of non-small cell lung cancer / Nicholas Lamparella, Amit Barochia, Salah Almokadem -- Impact of genetic targets on therapy in head and neck squamous cell carcinoma / Irina Chaikhoutdinov, David Goldenberg -- Tyrosine kinase targeted treatment of chronic myelogenous leukemia and other myeloproliferative neoplasms / Ajit Bisen, David F. Claxton -- Targeted tehrapy of multiple myeloma / Nathan G. Dolloff, Giampaolo Talamo -- Current and future trials of targeted therapies and cutaneous melanoma / Matthew S. Evans...[et al.] -- Current approaches to epigenetic therapy for the treatment of mantle cell lymphoma / Vikas Ghai...[et al.] -- Impact of genetic targets on primary brain tumor therapy: what's ready for prime time / O. Zalatimo...[et al.] -- Rational therapy for renal cell carcinoma based on its genetic targets / Jaime Messer, Joseph Drabick, Matthew Kang -- Molecular and genetic markers of follicular-cell thyroid cancer : etiology and diagnostic and therapeutic opportunities / Neerav Goyal...[et al.] -- Genetic targets in pediatric acute lymphoblastic leukemia / Chandrika Gowda, Sinisa Dovat -- Emerging molecular therapies for the treatment of acute lymphoblastic leukemia / Monali Vasekar...[et al.] -- Impact of genetic targets on prostate cancer therapy / Hassan Sheikh...[et al.] -- Small-cell lung cancer : an update on targeted therapues / Monika Joshi, Ayodele Ayoola, Chandra P. Belani -- Impact of genetic targets on cancer therapy in acute myelogenous leukemia / Mithun Vinod Shah, Amit Barochia, Thomas P. Loughran.
    Also available: Print – 2013
  • 2013From: CRCnetBASE
    2013Limited to 1 simultaneous usersFrom: ProQuest Ebook Central
    Divya Srinivasan.
    HIPAA : stakeholder impacts and effects of provisions of the HITECH Act -- Organizational culture : what is needed to adopt HIT across different types of hospitals? -- Health economics : organizational finance and healthcare IT -- Cost benefit analysis and funding EMRs -- Analyzing the presence of EMRs across different health providers -- EMR impacts on quality of care and cost to the patient -- The physician and perceptions : medical malpractice and impacts from HIT usage -- Reduction in bioterrorism through the usage of EMRs -- The direction of health informatics and the future : the E-health industry.
  • 2012From: Karger
    volume editor, Cynthia Garcia-Coll.
    Introduction: the global, the local-- children and immigration around the world / C. Garcia Coll -- Quiet in the eye of the beholder: teacher perceptions of Asian immigrant children / Y. Yamamoto, J. Li -- The impact of social contexts in schools: adolescents who are new to Canada and their sense of belonging / M.H. Gagné, J.D. Shapka, D.M. Law -- Are immigrant children in Italy better adjusted than mainstream Italian children? / R. Dimitrova, A. Chasiotis -- Ethnic identity, acculturation orientations, and psychological well-being among adolescents of immigrant background in Kenya / A. Abubakar [and others] -- Immigrant youth adaptation in context: the role of society of settlement / D.L. Sam, G. Horenczyk -- Examining spiritual capital and acculturation across ecological systems: developmental implications for children and adolescents in diverse immigrant families / S.S. Oh, H. Yoshikawa -- Immigrant youth and discrimination / P. Vedder, M. van Geel -- Immigrant family separations: the experience of separated, unaccompanied, and reunited youth and families / C. Suárez-Orozco, M.G. Hernández.
  • 2008From: Springer
    edited by Bernard Faye and Yuriy Sinyavskiy.
  • 2014From: Springer
    Susan Redline, Nathan A. Berger, editors.
    This volume on the Impact of Sleep and Sleep Disturbances on Obesity and Cancer continues the transdisciplinary approach of this series with chapters authored by the leading experts in this field, focused on the normal regulation of the restorative sleep associated processes across the lifespan, the major mechanisms of sleep and circadian rhythm disturbances and the behavioral, physiologic, biochemical and molecular consequences of sleep disturbances. These areas, in turn, are discussed in relationship to their effects on cancer incidence and progression. Students and research scientists involved in all aspects of energy balance and cancer research and patient care should find this volume useful to better understand the causes, contributions and consequences of sleep and circadian rhythm disturbances and their relation to cancer. The volume outlines many exciting areas where research is needed. In addition to its value for researchers, it should be useful to all physicians and health care personnel who care for cancer patients and cancer survivors to better understand the importance of sleep, consequences of sleep disturbances and benefits of their correction.
  • 2009From: Springer
    M. Molls, P. Vaupel, C. Nieder, M.S. Anscher (eds.).
  • by Nabihah Maqbool, Janet Viveiros, and Mindy Ault.
  • 2016From: Cambridge
    edited by Paul J. Beggs.
    The authoritative assessment of the many climate change impacts on allergens and allergic diseases, for researchers, clinicians, students.
  • This issue brief provides a literature review of the effects of Medicaid expansion, with a focus on the impacts of the ACA's Medicaid expansion in 2014 and 2015. Specifically, the brief focuses on the effects of expansion on health coverage and access, affordability and quality of care. The first section of this issue brief examines the evidence to date on the impact of Medicaid expansion on health coverage. The second section explores the beneficiary impacts of Medicaid expansion, by examining access to care and utilization. The third section examines research to date on affordability and quality including enrollee financial well-being, satisfaction and experience. This literature review adds to prior ASPE research on the economic impacts of Medicaid expansion including the impact on the cost of uncompensated care.
  • Laura Marie Prolo.
    Lysosomal storage disorders are inherited diseases caused by defects in lysosomal function. The free sialic acid storage disorders are allelic diseases that are caused by mutations in the gene encoding a lysosomal membrane protein called sialin. This protein transports the acidic sugar, sialic acid, out of lysosomes after it has been cleaved off of glycoconjugates undergoing degradation. Accumulation of sialic acid in lysosomes defines these disorders, but it is not known how this biochemical defect leads to the clinical manifestations. Significant advances in our understanding of the pathophysiology and in treatment have been hindered by the lack of an animal model. In the studies described here I characterize a sialin deficient mouse and provide evidence that it faithfully models important aspects of the human disease. A major finding in the human disease and in the sialin-/- mouse is impaired central nervous system (CNS) myelination. To investigate potential mechanisms underlying CNS hypomyelination, I studied oligodendrocyte development and myelination in optic nerves of the sialin deficient mice. I found reduced numbers of myelinated axons, but the myelin that was present appeared grossly normal. Migration and density of oligodendrocyte precursor cells (OPCs) were normal; however, I observed a marked decrease in the number of postmitotic oligodendrocytes and an associated increase in the number of apoptotic cells during the later stages of myelinogenesis. These findings suggest that a defect in maturation of cells in the oligodendrocyte lineage leads to increased apoptosis and underlies the myelination defect associated with sialin loss. I hypothesized that improper metabolism of sialic acid containing proteins and lipids (gangliosides) may explain some aspects of the disease phenotype. I found a delay in the developmentally regulated reduction in expression of polysialic acid-neural cell adhesion molecule (PSA-NCAM), a glycoconjugate that inhibits myelin formation, which provides a potential molecular mechanism for the impaired myelination and reduction in oligodendrocyte number. Further, I found elevated levels of gangliosides in the sialin-/- mouse brain with the most noticeable change in the level of ganglioside GM2. To further studies of the myelination defect, I have established a cerebellar slice-OPC coculture myelination assay. This ex vivo system will allow investigators to test specific hypotheses about the cellular and molecular basis of the myelination defect and can eventually be used to assess potential treatments.
  • 2009From: IngentaConnect
    Galina Kichigina.
    Part I. The German laboratory and 'scientific medicine' in the late 1850s and early 1860s: a Russian view -- 1. The Old-new tradition -- 2. Physiologist-physicists: foundation of the discipline -- 3. A Viennese prelude: Sechenov's research at Ludwig's laboratory -- 4. Berlin wins over Paris and Vienna: Botkin's view on European clinics -- 5. 'Alt Heidelberg, du feine ...' -- Part II. The St Petersburg Medico-Surgical Academy and experimental science -- 6. Military medical education: the aftermath of the Crimean War -- 7. The Winds of change: reformation of the Medico-Surgical Academy -- 8. The 'Medico-Chemical Academy': Zinin's laboratory -- 9. Synthesis and symphonies: Borodin's laboratory -- 10. 'Scientific medicine': Botkin's teaching clinic and laboratory -- 11. The New discipline of Russian physiology: Sechenov's labortory 12. A Few steps further: the operation of the physiological laboratory under Cyon -- Part III. From physics and chemistry of the body to physical chemistry: Sechenov's research on blood gases and salt solutions -- 13. Russian universities in the sea of change, 1870-1886 -- 14. Sechenov at Novorossiisk University: new laboratory, new challenges -- 15. A Simple model: transition from blood-gas research to studies on salt solutions -- 16. Sechenov at St Petersburg: 'Galvanic studies'-- a final proof -- 17. The Context to Sechenov's study of solution: the Mendeleev-Ostwald debate on the theory of solutions -- The Universal law: expectations and disappointments.
    Also available: Print – 2009
  • 2010From: ClinicalKey
    Arun K. Garg.
    Get the practical information you need to add dental implants to your practice! Dr. Arun Garg, a leading dental implant educator, clinician, and researcher, uses a clear, succinct writing style to inform and guide you through the full scope of dental implantology. A patient-focused approach covers surgical templates and techniques, sterilization, pharmacology, bone biology, complications, and more. A robust appendix offers handy information including insurance codes, consent forms, surgical tray set-ups, and food recipes for patients recovering from surgery. A practical yet comprehensive approach covers all aspects of implant dentistry from patient history to post-operative care, with minimal use of jargon, in an easy-to-read format. Outstanding photos help you visualize and understand patient outcomes. An appendix on post-operative instructions includes a unique section on delicious yet recovery-specific recipes.
  • 2015From: Springer
    Ann Wennerberg, Tomas Albrektsson, Ryo Jimbo, editors.
    This book provides the reader with the knowledge required in order to understand the chemical, physical, mechanical, and topographical aspects of implant surfaces, as well as their impact on the biological response. Common ways to modify implant surfaces are described, and methods for the evaluation of surface properties are presented in an easy-to-read style. Experimental results that have contributed to surface modifications relevant for commercial available implants are presented, with emphasis on in vivo and clinical studies. While the focus is primarily on surface modifications at the micrometer and nanometer levels, alterations at the millimeter level are also covered, including thread designs and their possible influence on stress distribution. In addition, it is analyzed how surface alterations have changed the clinical long-term results for certain groups of patients. Care is taken to ensure that assessments are well balanced and draw attention to the potential disadvantages of different surfaces; for example, surfaces that may be more prone to biofilm accumulation are identified, with discussion of the clinical evidence.
  • 2014From: Wiley
    edited by Evgeny Katz.
  • 2011From: Karger
    volume editors, Martin Kompis, Marco-Domenico Caversaccio.
    Historical background of bone conduction hearing devices and bone conduction hearing aids / Mudry, A., Tjellström, A. -- Acoustic and physiologic aspects of bone conduction hearing / Stenfelt, S. -- An overview of different systems : the bone-anchored hearing aid / Dun, C.A.J. ... [et al.] -- The ponto bone-anchored hearing system / Westerkull, P. -- Partially implantable bone conduction hearing aids without a percutaneous abutment (otomag) : technique and preliminary clinical results -- Siegert, R. -- Surgery for the bone-anchored hearing aid / Arnold, A., Caversaccio, M.-D., Mudry, A. -- Paediatric baha / McDermott, A.-L., Sheehan, P. -- Complications of bone-anchored hearing devices / Wazen, J.J., Wycherly, B., Daugherty, J. -- Audiological results with Baha in conductive and mixed hearing loss / Pfiffner, F.; Caversaccio, M.-D.; Kompis, M. -- Conductive hearing loss and bone conduction devices : restored binaural hearing? / Agterberg, M.J.H. ... [et al.] -- Bone-anchored devices in single-sided deafness / Stewart, C.M.; Clark, J.H.; Niparko, J.K. -- Factors influencing the decision for baha in unilateral deafness : the Bern benefit in single-sided deafness questionnaire / Kompis, M. ... [et al.] -- Challenges and recent developments in sound processing for Baha / Flynn, M.C. -- Headbands, testbands and softbands in preoperative testing and application of bone-anchored devices in adults and children / Zarowski, A.J. ... [et al.] -- Bone-anchored hearing aids versus conventional hearing aids / Banga, R. ... [et al.] -- The future of bone conduction hearing devices / Håkansson, B.
  • 2013From: Springer
    David Korpas.
    History and development of pacing -- Basic principles of cardiac pacemaker technology -- Heart anatomy and physiology -- Pharmacological treatment of cardiac rhythm disorders -- Pacing modes -- Indications for implantable system treatment -- Leads -- Pacing systems -- Pacemaker timing -- Implantable cardioverter-defibrillators -- Cardiac resynchronization therapy -- Implantation, explantation, and replacement of devices and leads -- Patient follow-up -- Electromagnetic compatibility and technical requirements.
  • 2007From: Springer
    Luc J. Jordaens and Dominic A.M.J. Theuns.
  • Thomas Daniel O'Sullivan.
    Molecular imaging is an established technique used to visualize and quantify functional information about biological processes in living systems. In vivo fluorescence imaging, in particular, is a molecular imaging technique capable of quantitatively imaging one or more fluorophores at high spatial and temporal resolution with high sensitivity, either at microscopic or macroscopic (whole-body) scales. While current fluorescent imaging technologies have led to key advances in the understanding of biology and biochemistry, there are limitations. Modern in vivo fluorescence imagers are bulky, and typically take snapshots, and only sample discrete points of continuous, dynamic processes. In order to overcome these obstacles and enable long-term, continuous fluorescence imaging in live animals, we have miniaturized the components of the optical imaging system, allowing for direct implantation. Miniature fluorescence sensors have been fabricated to match a particular fluorescent probe utilizing semiconductor processing technology and appropriate materials. We present the design and fabrication of a monolithically integrated semiconductor (GaAs-based) sensor for far-red to near infrared (NIR) in vivo fluorescence sensing. The sensor incorporates three basic components of a fluorescence system, including: a 675nm vertical-cavity surface-emitting laser (VCSEL) excitation source, a GaAs PIN photodiode, and a fluorescence emission filter. We have packaged the sensors in several integrated configurations, and developed readout mechanisms that include a system that can be implanted in small rodents. We have utilized this device to demonstrate that in vivo fluorescence imaging is possible with miniaturized, un-cooled semiconductor devices, including a demonstration of sensing in a freely-moving rodent. Such miniaturized, implantable biomedical devices have the potential to accelerate pre-clinical research and revolutionize clinical care by providing an inexpensive means for diagnosis, monitoring disease progression, and evaluating long-term treatment efficacy. By integrating this implantable sensor with the appropriate read-out electronics and wireless telemetry, un-tethered operation can ultimately be achieved.
  • 2014From: Springer
    Gauri Mankekar, editor.
    Hearing loss can vary in type ranging from conductive, mixed to sensorineural, as well as in degree from mild, moderate, severe to profound. There could also be multiple permutations and combinations like moderate mixed hearing loss or severe conductive hearing loss. In addition, the hearing loss could be unilateral or bilateral. While cochlear implants were devised for bilateral profound sensorineural hearing loss, various other devices have been invented for other types of hearing losses. Research continues to design a suitable implant which would amplify sound for patients who cannot be candidates for cochlear implants.
  • David H. Peters, Nhan T. Tran, Taghreed Adam.
    Also available: Print – 2013
  • 2014From: WHO
    Also available: Print – 2014
  • 2008From: CRCnetBASE
    Azad Adam.
  • 2010From: CRCnetBASE
    Donnell R. Christian, Jr., Stephanie Drilling.
  • 2014From: CRCnetBASE
    edited by Victoria Stodden, Friedrich Leisch, Roger D. Peng.
    Part 1. Tools -- part 2. Practices and guidelines -- part 3. Platforms.
  • World Health Organization.
    PrintStatus: Not Checked OutLane Catalog Record
  • 2010From: Karger
    editors, Alan Lucas, Maria Makrides, Ekhard E. Ziegler.
    Growth and later health : a general perspective / Lucas, A -- Early infancy as a critical period for development of obesity and related conditions / Gillman, M.W -- Leptin, nutrition, and the programming of hypothalamic feeding circuits / Bouret, S.G -- Early growth and ageing / Chen, J.-H., Cottrell, E.C., Ozanne, S. -- Does early growth affect long-term risk factors for cardiovascular disease? / Singhal, A. -- Developing world perspective : the importance of growth for short-term health / Adair, L.S. -- Postnatal growth and development in the preterm and small for gestational age infant / Cooke, R.J. -- Interrelationship between growth and development in low and middle income countries / Martorell, R., Nguyen, P. -- Role of long-chain polyunsaturated fatty acids in neurodevelopment and growth / Makrides M., Gibson, R.A. -- Growth and development of the brain and impact on cognitive outcomes / Hüppi, P. -- Benefits and harms of iron supplementation in iron-deficient and iron-sufficient children / Domell'f, M. -- Effects of selective dropout on infant growth standards / Van Buuren, S. -- The 2000 centers for disease control and prevention growth charts : several insights after 8 years / Ogden, C.L. ... [et al.] -- Growth charts compared / Ziegler, E.E., Nelson, S.E. -- Body composition in infancy : impact on health later in life / Ellis, K.J. -- Endocrinology of growth / Rosenfeld, R.G.
  • 2013From: Karger
    editors, Maria Makrides, Juan B. Ochoa, Hania Szajewska.
    Arginine and asthma / C.R. Morris -- Changes in arginine metabolism during sepsis and critical illness inÿchildren de betue, C.T.I. / N.E.P. Deutz -- Arginine deficiency caused by myeloid cells : importance, identification and treatment / J.B. Ochoa -- Glutamine supplementation in neonates : is there a future? / J. Neu -- Insulin in human milk and the use of hormones in infant formulas / R. Shamir, N. Shehadeh -- Diet, gut enterotypes and health : is there a link? / F.D. Bushman, J.D. Lewis, G.D. Wu -- Understanding immunomodulatory effects of probiotics / B. Pot, B. Folign, C. Daniel, C. Grangette -- Transforming growth factor and intestinal inflammation : the role of nutrition / F.M. Ruemmele, H. Garnier-Lenglin -- Microbiota modulation: can probiotics prevent/treat disease inÿpediatrics? -- / H. Szajewska -- Membrane composition and cellular responses to fatty acid intakes and factors explaining the variation in response / C. Agostoni, P. Ris, F. Marangoni -- Docosahexaenoic acid and its derivative neuroprotectin D1 displayÿneuroprotective properties in the retina, brain and centralÿnervous system / N.G. Bazan, J.M. Calandria, W.C. Gordon -- Branched-chain fatty acids in the neonatal gut and estimated dietary intake in infancy and adulthood / R.R. Ran-Ressler, R.P. Glahn, S. Bae, J.T. Brenna -- Clinical overview of effects of dietary long-chain polyunsaturated fatty acids during the perinatal period / S.A. Scholtz, J. Colombo, S.E. Carlson -- Dietary n-3 LC-PUFA during the perinatal period as a strategy to minimize childhood allergic disease / M. Makrides, A.W. Gunaratne, C.T. Collins.
  • 2015From: Karger
    editors, Rémy F. Meier, B. Ravinder Reddy, Peter B. Soeters.
    Basics in clinical medical nutrition / Meier, R.F., Forbes, A. -- Macronutrient metabolism in starvation and stress / Soeters, P.B. -- Noncaloric benefits of carbohydrates / Reddy, B.R. -- Biological value of protein / Moore, D.R., Soeters, P.B. -- Enteral nutrition : whom, why, when, what, and where to feed? / Reddy, B.R. -- Management of the metabolic syndrome and the obese patient with metabolic disturbances : South Asian perspective / Misra, A., Bhardwaj, S. -- Nutritional issues in the short bowel syndrome : total parenteral nutrition, enteral nutrition and the role of transplantation / O'Keefe, S.J.D. -- Nutrition in cancer / Ravasco, P. -- Nutritional therapy for critically ill patients / Martindale, R.G., Warren, M., Diamond, S., Kiraly, L. -- Perioperative nutritional intervention : where are we? / Hoos, T., Warren, M., Martindale, R.G. -- Health economics in medical nutrition : an emerging science / Nuijten, M. -- Nutrition, frailty, cognitive frailty, and prevention of disabilities with aging / Vellas, B., Secher, M., Gillette, S.
  • 2002From: WHO
    Chapter 1. Introduction -- Chapter 2. A Short History of Involvement in Drug Safety Monitoring by WHO -- Chapter 3. Partners in Pharmacovigilance -- Chapter 4. Pharmacovigilance in Drug Regulation -- Chapter 5. Pharmacovigilance in Clinical Practice -- Chapter 6. Pharmacovigilance in International Health -- Chapter 7. Conclusion and Considerations for the Future.
  • 2007From: Oxford
    edited by M.A. Gómez Sánchez, A. Torbicki.
  • 2015From: Springer
    Elvira Beracochea, editor.
    This direct, accessible guide uses a human rights perspective to define effectiveness in aid delivery and offer a robust framework for creating sustainable health programs and projects and assessing their progress. Geared toward hands-on professionals in such critical areas as food aid, maternal health, and disease control, it lays out challenges and solutions related to funding, planning, and complexity as individual projects feed into and impact larger health and development systems. Contributors clarify optimum roles of government, academia, NGOs, community organizations, and the private sector in aid delivery to inspire readers' broader and deeper uses of teamwork, communication, and imagination. Throughout, the guiding principles of justice, equity, and respect that underlie foundational documents such as the Millennium Declaration inform this visionary work. Included in the coverage: Assessing the effectiveness of health projects. Scaling-up of high-impact interventions. Aid effectiveness and private sector health organizations. When charity destroys dignity and sustainability. Effective conversations in global health projects. Lessons from the field on sustainability and effectiveness. For professionals in global health and development, Improving Aid Effectiveness in Global Health is a trusted and encouraging mentor. This volume gives its readers the necessary logistical and attitudinal tools to bring about lasting change, and shows how to use them meaningfully in both the short term and the long run.
  • report from the Task Force on Specific Populations ; prepared by Office of Disability, Aging and Long-Term Care Policy, Office of the Assistant Secretary for Planning and Evaluation, U.S. Department of Health and Human Services.
    The National Plan to Address Alzheimer's Disease requires the U.S. Department of Health and Human Services (HHS) Office of the Assistant Secretary for Planning and Evaluation (ASPE) and the Administration for Intellectual and Developmental Disabilities (AIDD) within the HHS Administration for Community Living (ACL) to establish a task force to create a plan of action to address the needs of specific populations disproportionally affected by Alzheimer's disease. These populations include people with younger-onset dementia, racial and ethnic minorities, and persons with Down syndrome and other intellectual disabilities. This report summarizes input and recommendations received from a wide variety of stakeholders for consideration by the members of the Federal Interagency Task Force.
  • Joanne Lynn, Janice Lynch Schuster, Anne Wilkinson, Lin Noyes Simon ; foreword by Donald M. Berwick.
    PrintStatus: Not Checked OutLane Catalog Record
    Introduction: continuous quality improvement for better end-of-life care -- How to make improvement happen -- Preventing, assessing and treating pain -- Managing dyspnea and ventilator withdrawal -- Beyond the living will: advance care planning for all stages of health and disease -- Supporting people in difficult times: relationships, spirituality, and bereavement -- Continuity of care: improving transitions, continuity, and coordination of care in the health care system -- Caring for caregivers: helping staff to provide good care -- Hospital-based palliative care consults and units -- Law , policy, and finance -- Alzheimer's and other dementias: opportunities to honor life -- Opportunites to improve care for cancer patients -- Offering end-of-life services to patients with advanced heart or lung failure -- Depression and delirium -- Conclusion: getting started.
  • prepared by Minnesota Evidence-based Practice Center ; prepared for Agency for Healthcare Research and Quality, U.S. Department of Health and Human Services.
    OBJECTIVE: To examine existing system-, clinic-, provider-, and individual-level interventions to improve culturally appropriate health care for people with disabilities; lesbian, gay, bisexual, and transgender (LGBT) populations; and racial/ethnic minority populations. DATA SOURCES: Ovid MEDLINE(r), PsycINFO(r), Ovid Embase(r), and the Cochrane EPOC (Effective Practice and Organisation of Care) register; hand searches of references of relevant studies. REVIEW METHODS: Two investigators screened abstracts and full-text articles of identified references for eligibility. Eligible studies included randomized controlled trials (RCTs), prospective cohort studies, and other observational studies with comparators that evaluated cultural competence interventions aimed at reducing health disparities in the formal health care system. Two investigators abstracted data and assessed risk of bias. Given the sparse and patchy literature, which precluded pooling, a qualitative analysis is provided. RESULTS: Over 37,000 nonduplicated English-language citations were reviewed; 56 unique studies were identified as of June 2015: 20 randomized controlled trials (RCTs) and 5 observational studies for individuals with disabilities; 5 RCTs (6 manuscripts) and 6 observational studies for LGBT populations; and 14 RCTs (15 manuscripts), 4 observational studies, and 2 systematic reviews for members of racial and ethnic minorities. Interventions fell into four broad categories: (1) provider trainings and education; (2) interventions providing alteration of an established protocol, or the delivery of an established protocol, to meet the needs of a target population; (3) interventions prompting patients to interact with the formal health care system or health care providers; and (4) interventions aimed at providing culturally competent care at the point of service. Educational programs and trainings to improve professional students' and providers' cultural competence behavior are the most prevalent type of cultural competence intervention. Two existing high-quality systematic reviews of provider educational interventions for racial/ethnic minority populations found low-strength evidence that cultural competence training had mixed effects for intermediate outcomes and no effect on treatment outcomes. Sixteen studies aimed at changing provider attitudes and beliefs through training or curriculums were identified for the disability population. Eleven of these studies focused on reducing professional stigma toward people with serious or chronic mental illness; five focused on changing professional attitudes and beliefs about people with physical or intellectual disability. Three educational interventions were identified for the LGBT population. Several short-term effects were evaluated; however, long-term effects of provider training on provider cultural competence behavior in the clinical setting and subsequent patient health outcomes have not been evaluated for the disability and LGBT populations. Two included studies reported a potential harm from provider training: an increase in negative attitudes or stigma resulting from intervention. Interventions providing alterations of an established protocol were concentrated in the racial/ethnic minority populations. The 12 studies of culturally tailored health care interventions for racial/ethnic minority populations focused primarily on treatment of chronic physical or mental health conditions (e.g., diabetes, depression, substance abuse). Two psychological interventions were also tailored for members of the LGBT population. Another common type of intervention was to provide additional resources to encourage or empower patients to interact with the formal health care system and/or health care providers. The stated aims of these types of interventions were to increase receipt of screenings for which disparities are well documented (e.g., Pap tests for people with mobility impairments or colorectal cancer screening among Latino immigrants) or to help patients engage in medical decisionmaking. These studies met inclusion criteria if the intervention was conducted by a medical professional in a formal health care system. One potential limitation of these types of interventions is that they rely on strong identification with a common culture. The population groups highlighted in this review are large and diverse. Creating an intervention for "African Americans" or "women who have sex with women" may be differentially effective for specific subpopulations. The most common culturally competent point-of-service interventions were documents, similar to a hand-held medical record, that patients carried to their appointments to prompt providers to evaluate areas of known disparity for a specific population. These interventions may be coupled with provider notices or trainings. Virtual interventions were also considered culturally competent point-of-service interventions for some people with disabilities, as they create access in a unique way. These interventions are seen as conceptually parallel to infrastructure changes that improve access for people with physical disabilities. For the majority of included studies, the risk of bias was high. The most common methodological problems were lack of randomization to treatment, lack of attention control, little or no followup, and failure to report unintended consequences. Large segments of vulnerable or disadvantaged populations--such as children with disabilities; people who are gender nonconforming or transgender; or numerous racial or ethnic groups, including Native Americans or Alaskan Natives--remain essentially invisible in the cultural competence literature. The issue is compounded for people who are members of more than one priority population. CONCLUSIONS: None of the included studies measured the effect of cultural competence interventions on health care disparities. Most of the training interventions measured changes in professional attitudes toward the population of interest but did not measure the downstream effect of changing provider beliefs on the care delivered to patients. Interventions that altered existing protocols, empowered patients to interact with the formal health care system, or prompted provider behavior at the point of care were more likely to measure patient-centered outcomes. The medium or high risk of bias of the included studies, the heterogeneity of populations, and the lack of measurement consensus prohibited pooling estimates or commenting about efficacy in a meaningful or responsible way. The term "cultural competence" is not well defined for the LGBT and disability populations, and is often conflated with patient-centered or individualized care. There are many gaps in the literature; many large subpopulations are not represented.
  • David Mannheim, Margaret Chamberlin, Osonde A. Osoba, Raffaele Vardavas, Melinda Moore; prepared for the Office of the Secretary of Defense.
    "This report describes decision-support tools, including models and nonmodeling approaches, that are relevant to infectious disease prevention, detection, and response and aligns these tools with real-world policy questions that the tools can help address. The intended audience includes technical experts - for example, modelers and subject-matter experts - and the policymakers that those experts can support. On one hand, this overview should help modelers and other technical experts understand the questions that policymakers will raise and the decisions they must make. On the other hand, many policymakers can benefit from a basic understanding of the capabilities and limitations of the different tools that may inform their decisions. This report describes the characteristics, requirements, uses, applicability, and limitations of three classes of theory-based models (population, microsimulation, agent-based simulation) and two classes of statistical models (regression-based and machine-learning), as well as several complementary nonmodeling decision-support approaches. The report then aligns all of these tools and approaches with a set of real-world policy questions. Finally, based on a review of published literature, an assessment of the different models and nonmodeling approaches, and recent experiences (such as the 2009 influenza pandemic), the authors recommend nine best practices for using modeling and decision-support tools to inform policymaking"--Back cover.
  • 2015From: NAPUser has to register to download.
    VideoFrom: NAP
    Committee on Diagnostic Error in Health Care ; Erin P. Balogh, Bryan T. Miller, and John R. Ball, editors ; Board on Health Care Services, Institute of Medicine, The National Academies of Sciences, Engineering, and Medicine.
    Getting the right diagnosis is a key aspect of health care -- it provides an explanation of a patient's health problem and informs all subsequent health care decisions. The diagnostic process is a complex, collaborative activity that involves clinical reasoning and information gathering to determine a patient's health problem. According to Improving Diagnosis in Health Care, diagnostic errors -- inaccurate or delayed diagnoses -- persist throughout all settings of care and continue to harm an unacceptable number of patients. It is likely that most people will experience at least one diagnostic error in their lifetime, sometimes with devastating consequences. Diagnostic errors can lead to negative health outcomes, psychological distress, and financial costs. If a diagnostic error occurs, inappropriate or unnecessary treatment may be given to a patient or appropriate (and potentially lifesaving) treatment may be withheld or delayed.Improving Diagnosis in Health Care, a continuation of the landmark Institute of Medicine reports To Err is Human: Building a Safer Health System (2000) and Crossing the Quality Chasm: A New Health System for the 21st Century (2001) finds that diagnosis -- and, in particular, the occurrence of diagnostic errors -- has been largely unappreciated in efforts to improve the quality and safety of health care. Without a dedicated focus on improving diagnosis, diagnostic errors will likely worsen as the delivery of health care and the diagnostic process continue to increase in complexity. Just as the diagnostic process is a collaborative activity, improving diagnosis will require collaboration and a widespread commitment to change among health care professionals, health care organizations, patients and their families, researchers, and policy makers. The recommendations of Improving Diagnosis in Health Care contribute to the growing momentum for change in this crucial area of health care quality and safety
  • Christina Y. Huang.
    Chronic diseases are a serious public health problem in America, but risk for many chronic diseases can be modified by diet. The “food environment” (the physical environment, or settings, in which there are opportunities to eat or buy foods) has been identified as having a potential impact on diet and health outcomes. Recent policies propose changing the food environment, for example, building new supermarkets in poor neighborhoods. This dissertation examines the role of the food environment as a policy lever to improve diet, with a focus on sugar sweetened beverage (SSB) consumption.
  • 2011From: ProQuest Ebook Central
    Committee on Health Impact Assessment, Board on Environmental Studies and Toxicology, Division on Earth and Life Studies, National Research Council, National Research Council of the National Academies.
    "Many Americans believe that the United States has one of the best health-care systems in the world and that consequently Americans enjoy better health than most of the world's populations. The data, however, do not support that belief. In fact, the United States is ranked 32nd in the world in life expectancy even though it is ranked third in total expenditures on health care as a percentage of gross domestic product (GDP). Clearly, good health is determined by more than money spent on the health-care system. In fact, a growing body of research indicates that living conditions - including such factors as housing quality, exposure to pollution, and access to healthy and affordable foods and safe places to exercise - have a greater effect on health. That research highlights the importance of considering health in developing policies, programs, plans, and projects, including ones that may not appear at first to have an obvious relationship to health. Health impact assessment (HIA) has arisen as an especially promising way to factor health considerations into the decision-making process. It has been defined in various ways but essentially is a structured process that uses scientific data, professional expertise, and stakeholder input to identify and evaluate public-health consequences of proposals and suggests actions that could be taken to minimize adverse health impacts and optimize beneficial ones"--Publisher's description.
  • 2013From: Wiley
    edited by Graham Thornicroft, Mirella Ruggeri, David Goldberg.
    The nature and scale of the global mental health challenge / Mirella Ruggeri, Graham Thornicroft, & David Goldberg -- Scaling up mental health care in resource poor settings / Shekhar Saxena, Benedetto Saraceno, and Justin Granstein -- Swings and roundabouts of community psychiatry : the UK fairground / Peter Tyrer -- Mental health services and recovery / Mike Slade ... [et al.] -- Implementing evidence-based treatments in routine mental health services / Antonio Lasalvia and Mirella Ruggeri -- The need for new models of care for people with severe mental illness in low- and middle-income countries / Ruben Alvarado ... [et al.] -- The role of primary care in low- and middle- income countries / David Goldberg, Graham Thornicroft and Nadja van Ginneken -- Meeting the challenge of physical co-morbidity and unhealthy lifestyles / Lorenzo Burti ... [et al.] -- Complex interventions in mental health services research : potential, limitations and challenges / Thomas Becker and Berndt Puschner -- The feasibility of applying the clinical staging paradigm to the care of people with mental disorders / Javier Vâazquez-Bourgon ... [et al.] -- Work, mental health, and depression / Aart Schene ... [et al.] -- Training mental health providers in better communication with their patients / Christa Zimmermann ... [et al.] -- Making an economic case for community mental health services / Martin Knapp -- Incorporating local information and prior expert knowledge to evidence-informed mental health system research / Luis Salvador-Carulla ... [et al.] -- Innovative epidemiological methods / Francesco Amaddeo ... [et al.] -- Routine outcome monitoring : a tool to improve the quality of mental health care? / Sjord Sytema and Lian van der Krieke -- Psychiatric case registers : their use in the era of global mental health / Povl Munk-Jorgensen ... [et al.] -- Can brain imaging address psychosocial functioning and outcome in schizophrenia? / Marcella Bellani, Nicola Dusi, and Paolo Brambilla -- Statistics and the evaluation of the effects of randomised health care interventions / Graham Dunn -- Service user involvement in in mental health research / Diana Rose -- Psychotropic drug epidemiology and systematic reviews of randomised clinical trials : the roads travelled, the roads ahead / Andrea Cipriani, Michela Nosè, and Corrado Barbui -- Services for people with severe mental disorders in high-income countries : from efficacy to effectiveness / Paul Bebbington, Elizabeth Kuipers & David Fowler -- The management of mental disorders in the primary care setting -- Matteo Balestrieri -- How many wobbly planks in the platform of mental health care? / Norman Sartorius -- Treatment gaps and knowledge gaps in mental health : schizophrenia as a global challenge / Assen Jablensky.
  • 2008From: Springer
    Ira B. Lamster, Mary E. Northridge, editors ; foreword by Jeanette C. Takamura.
    Part I: Population health and well-being -- The aging U.S. population / Steven M. Albert -- The Oral disease burden faced by older adults / Ira B. Lamster and Natalie D. Crawford -- Social disparities in oral health and health care for older adults / Luisa N. Borrell -- Access, place of residence and interdisciplinary opportunities / Janet A. Yellowitz -- Part II: Health and medical considerations -- Movement disorders in dental practice / Nina M. Browner and Steven Frucht -- Cognitive impairment / James M. Noble and Nikolaos Scarmeas -- Musculoskeletal conditions / Jennifer L. Kelsey -- Cardiovascular, cerebrovascular diseases and diabetes mellitus: co-morbidities that affect dental care for the older patient / Neerja Bhardwaj ... [et al.] -- Geriatric pharmacology: principles and implications for oral health / Brian C. Scanlan -- Management of alcohol and tobacco dependence in older adults / David A. Albert -- Part III: Oral health and dental considerations -- Normal oral mucosal, dental, periodontal, and alveolar bone changes associated with aging / Stefanie L. Russell and Jonathan A. Ship -- The relationship between periodontal disease and systemic disease in the elderly / Dana L. Wolf and Panos N. Papapanou -- Caries, tooth loss, and conventional tooth replacement for older patients / Ejvind Budtz-Jørgensen and Frauke Müller -- Implant dentistry as an approach to tooth replacement for older adults / Hans-Peter Weber -- Saliva and the salivary glands in the elderly / Louis Mandel -- Mastication, nutrition, oral health and health in older patients / Angus W.G. Walls -- Orofacial pain and neurological disorders affecting the head and neck / Ali Makki and Susan Roche -- Oral pathology affecting older adults / David J. Zegarelli, Victoria L. Woo, and Angela J. Yoon -- Part IV: Professional recommendations and future needs -- Educating the dental profession / Lynn M. Tepper -- Dental services among elderly Americans: utilization, expenditures, and their determinants / L. Jackson Brown -- Conclusion: interdisciplinary planning to meet the oral health care needs of older adults / Mary E. Northridge and Ira B. Lamster.
  • 2015From: Springer
    Patricia A. Ganz, editor.
    In collaboration with the Breast Cancer Research Foundation (BCRF), this timely volume provides a comprehensive review on all areas of breast cancer survivorship research, highlighting research that is underway or in development. The range of topics covered include the biology and management of fatigue and cognitive dysfunction on breast cancer survivorship, the biology and management of Neuropathy and Arthralgias, the ongoing research on the biology of diet and lifestyle interventions in survivors, and more. With the tremendous growth in the number of breast cancer survivors, researchers have moved beyond describing the outcomes of breast cancer treatments and are focusing their research on understanding the mechanisms underlying the development of the late effects of breast cancer treatment, as well as the development and evaluation of interventions to mitigate some of the persistent symptoms--topics which are also explored in this volume. In addition, current research on how to improve survivorship and reduce recurrence of breast cancer through behavioral and lifestyle modifications is also discussed.
    Also available: Print – 2015
  • Jerome A. Osheroff, Jonathan M. Teich, Donald Levick, Luis Saldana, Ferdinand T. Velasco, Dean F. Sitting, Kendall M. Rogers, Robert A. Jenders.
    PrintStatus: Not Checked OutLane Catalog Record
  • 2013From: Wiley
    edited by Richard Grol, Michel Wensing, Martin Eccles and David Davis.
    As innovations are constantly being developed within health care, it can be difficult both to select appropriate new practices and technologies and to successfully adopt them within complex organizations. It is necessary to understand the consequences of introducing change, how to best implement new procedures and techniques, how to evaluate success and to improve the quality of patient care. This comprehensive guide allows you to do just that. Improving Patient Care, 2nd edition provides a structure for professionals and change agents to implement better practices in health care.
  • 2010From: Springer
    Hayden Bosworth, editor.
    Introduction -- Physical activity and adherence -- Improving dietary adherence -- Medication adherence -- Smoking cessation and adherence -- Cancer screening adherence -- Hormonal contraceptives and adherence -- Chronic pain and adherence -- Adherence and psychotherapy -- Adherence to treatment for depression -- Adherence in the treatment of HIV and other infectious diseases -- Adherence and substance use -- Special considerations of medication adherence in childhood and adolescence -- Special considerations of adherence in older adults.
  • 2016From: Springer
    Jonathan Hunter, Robert Maunder, editors.
    Introduction -- Background: Fundamentals of Attachment Theory -- Advanced Attachment Concepts -- Specific populations: Family Practice/Somatization -- Diabetes -- Chronic Pain -- Nephrology/dialysis -- Hepatitis/obesity -- Cancer/ Palliative care -- The Disorganized attachment patient -- The interventions: Consultation and Liaison (C&L) -- Collaborative Care -- Psychotherapy -- Mentalizing -- The Future: What about the practitioner's attachment system -- Health care process/systems -- The Attachment approach to Medical Education -- The Attachment Lens on Psychosomatics -- Summary.
  • Thomas Bodenheimer, Kevin Grumbach.
    PrintStatus: Not Checked OutLane Catalog Record
    Primary care home -- New practice model for primary care -- Patient-centered care: finding the balance -- Improving primary care for patients with chronic illness -- Self-management support for people with chronic illness -- Improving timely access to primary care -- Alternatives to the 15-minute visit -- Computerizing the primary care home -- Health care teams in primary care -- Diagnosing and treating the primary care practice -- Payment for primary care -- Conclusion -- Some organizations and resources demonstrating innovative primary care practices -- Assessing your practice -- Diagnosing problems in your practice -- Primary care patient survey -- Primary care staff satisfaction survey -- Resources on cultural competence and health literacy -- Office visit cycle time -- Interruptions in the day's work -- Group visit starter kit -- Resources available from improving chronic illness care -- Patient assessment of chronic care -- Self-management support tools -- Self-management support assessment -- Review of evidence on the chronic care model -- Review of evidence on primary care teams.
  • 2012From: IARC
    edited by John I. Pitt, Christopher P. Wild, Robert A. Baan, Wentzel C.A. Gelderblom, J. David Miller, Ronald T. Riley, and Felicia Wu.
    "Mycotoxins are fungal toxins that contaminate many of the most frequently consumed foods and feeds worldwide, including staple foods consumed by many of the poorest and most vulnerable populations in the world. Therefore, human and animal exposure to one or more of this broad group of toxins is widespread. Mycotoxins have the potential to contribute to a diversity of adverse health effects in humans, including cancer, even at low concentrations. Economic burdens resulting from crop contamination are added to those on health. Given the ubiquitous nature of exposure in many countries, an urgent need exists for a coordinated international response to the problem of mycotoxin contamination of food. This book aims to sensitize the international community to the mycotoxin problem in a format that is accessible to a wide audience and is useful to decision-makers across a broad spectrum of disciplines, including agriculture, public health, marketing, and economics. The editors hope that this book will be a stimulus to governments, nongovernmental and international organizations, and the private sector to initiate measures designed to minimize mycotoxin exposure in high-risk populations. The book not only provides a scientific description of the occurrence and effects of mycotoxins but also goes further by outlining approaches to reduce mycotoxin exposure aimed at improving public health in low-income countries." -- WHO website
    Also available: Print – 2012
  • PrintStatus: Not Checked OutLane Catalog Record
    "Civil registration systems are used to record vital events -- including births, deaths, and marriages -- and have the potential to serve as the main source of national vital statistics. However, in many developing countries, civil registration and vital statistics systems are weak or nonexistent; as a result, key demographic, fertility and mortality statistics are not available on a continuous basis and do not cover large segments of the population. A first step in addressing such weaknesses is to undertake a review of current status with a view to identifying areas requiring improvement and prioritizing actions. This package of materials -- referred to as the World Health Organization (WHO) guidance tool -- provides comprehensive guidance on how to systematically evaluate the quality and functioning of civil registration and vital statistics systems. The package consists of two components: a detailed assessment tool, plus a rapid assessment tool available as text or as a spreadsheet, for ease of compilation of data. Both tools have been extensively peer reviewed by technical experts, and field tested in three countries. The aim is to help responsible authorities obtain a clear and comprehensive understanding of the strengths and weaknesses of their civil registration and vital statistics systems, and generate the evidence base for corrective action. The detailed assessment tool reviews the main aspects of the civil registration and vital statistics systems. These include the legal and regulatory framework; registration, certification and coding practices; and the compilation, tabulation and use of the resulting data. The tool comprises both a roadmap, which outlines the main steps in conducting the review, starting with the formation of a review committee of key stakeholders, and an assessment framework, which serves as a template for the detailed review. The focus throughout is on births, deaths and causes of death, because these are the fundamental events that countries need to know about in order to guide public health programmes, monitor population dynamics and measure key health indicators. The approach described in this guidance tool is largely directed to those countries where civil registration is established but is subject to inadequacies in terms of coverage, quality or both. Countries where civil registration is not established may find the approach useful, even though not all sections of the assessment framework will be relevant. If the extent of completeness or coverage of the vital statistics data is known, even incomplete information can yield valuable insights on mortality patterns and the main causes of death. The guidance tool emphasizes the importance of critically evaluating data quality by, for example, carrying out consistency and plausibility checks, and comparing the outputs of the systems with data from other sources on mortality and fertility levels and patterns. Statisticians, health planners and others compiling and analysing vital statistics should be strongly encouraged and helped to develop such critical appraisal skills as an essential component of overall system development. Countries or local governments using these materials will be better informed about the strengths and weaknesses of their current systems, and will be able to identify the processes or aspects that need to be improved. The outcome should be improved and more useful vital statistics to support health sector reforms and development policies and programmes"--Executive summary.
  • Jacquelyn Small ; in collaboration with Jim Mulry.
    PrintStatus: Not Checked OutLane Catalog Record
  • 2016From: AccessEmergency Medicine
    2016From: AccessMedicine
    Kenneth V. Iserson.
    Section I: The Situation -- Section II: Basic Needs -- Section III: Patient Assessment/Stabilization -- Section IV: Surgical Interventions -- Section V: Nonsurgical Interventions -- Section VI: Appendices.
    Also available: Print – 2016
  • 2012From: AccessMedicine
    2012From: AccessEmergency Medicine
    Kenneth V. Iserson.
    "Improvised Medicine is written for healthcare providers treating patients during a crisis situation or in a primitive environment, for diseases and disorders they have little or no hands-on experience with. The book begins with situational analysis and basic needs in a crisis, then moves on to cover specific triage, diagnosis, and stabilization efforts. It then provides medical interventions for surgical and non-surgical problems"--Provided by publisher.
  • edited by Elias Aboujaoude, Lorrin M. Koran.
    PrintStatus: Not Checked OutLane Catalog Record
    Compulsive buying : clinical aspects / Donald W. Black -- Compulsive buying : cultural contributors and consequences / April Lane Benson, Helga Dittmar, and Reeta Wolfsohn -- Kleptomania : clinical aspects / Lorrin M. Koran, Dana Bodnik, and Pinhas N. Dannon -- Kleptomania and the law / Brad Novak -- Pathological gambling : clinical aspects / Jon E. Grant and Brian L. Odlaug -- Pathological gambling : promoting risk, possessing ruin / Laura M. Letson -- Cash and casinos : an Indian perspective / Eileen M. Luna -- Trichotillomania : clinical aspects / Michael R. Walther, Benjamin T.P. Tucker, and Douglas W. Woods -- Trichotillomania : the view from dermatology / Drew Miller and Amy McMichael -- How to create a national advocacy organization / Christina S. Pearson -- Skin picking : clinical aspects / Celal Calikusu and Ozlem Tecer -- Skin picking : the view from dermatology / Rungsima Wanitphakdeedecha and Tina S.Alster -- Nail biting : clinical aspects / Timothy Ivor Williams -- Nail biting and other oral habits : a dental perspective / Sven E. Widmalm and Duane C. McKay -- Problematic internet use : clinical aspects / Timothy Liu and Marc N. Potenza -- Virtual violence : the games people play / Vladan Starcevic and Guy Porter -- Counseling in cyberspace : your e-therapist is on call / John H. Greist -- Hypersexuality : clinical aspects / Peer Briken, Andreas Hill, and Wolfgang Berner -- The sex industry : public vice, hidden victims / William M. Spice -- Intermittent explosive disorder : clinical aspects / Emil F. Coccaro and Michael S. McCloskey -- Violence against women : preventing a social scourge / Joan C. Chrisler and Sheila Ferguson -- Intimate partner violence : aggression at close quarters / Christy M. McKinney and Raul Caetano -- Pyromania : clinical aspects / Candice Germain and Michel Lejoyeux -- Arson : choking off the flames / Paul Schwartzman.
  • 2007From: Karger
    volume editor, John L. Meyer ; contributing editors, B.D. Kavanagh, J.A. Purdy, R. Timmerman.
  • 2011From: Karger
    volume editor, John L. Meyer ; advisory editors, L.A. Dawson, B.D. Kavanagh, J.A. Purdy, R. Timmerman.
    Over the last 4 years, IMRT, IGRT, SBRT: Advances in the Treatment Planning and Delivery of Radiotherapy has become a standard reference in the field. During this time, however, significant progress in high-precision technologies for the planning and delivery of radiotherapy in cancer treatment has called for a second edition to include these new developments. Thoroughly updated and extended, this new edition offers a comprehensive guide and overview of these new technologies and the many clinical treatment programs that bring them into practical use. Advances in intensity-modulated radiothera.
  • 2010From: Springer
    Bert Gordijn, Anthony Mark Cutter, editors.
    This volume assembles an interdisciplinary team of leading academics, industry figures, policymakers and NGOs to consider the legal, ethical and social issues that are raised by innovations in nanoscience and nanotechnology. By bringing together international experts from a diverse range of fields this volume addresses the implications and impact that nanotechnology has on society. Through the exploration of six key themes the contributors analyse both the impact of nanotechnology and the emergence of the concept of nanoethics. Each section includes authors from both sides of the political and scientific divide incorporating both positive and negative perspectives on nanotechnology, as well as including discussions of associated concepts such as converging technologies. The result provides for the widest and most balanced discussion of these issues to date.
  • 2007From: Springer
    edited by Darren Flower and Jon Timmis.
  • 2013From: Springer Protocols
    edited by Sandhya Kortagere.
    Virtual Screening in Drug Design -- In Silico Systems Biology Approaches for the Identification of Antimicrobial Targets -- Genome Comparisons as a Tool for Antimicrobial Target Discovery -- In Silico Models for Drug Resistance -- An In Silico Model for Interpreting Polypharmacological Relationships in Drug-Target Networks -- On Exploring Structure-Activity Relationships -- Molecular Dynamics Simulations in Drug Design -- Databases and In Silico Tools for Vaccine Design -- In Silico Models for B-Cell Epitope Recognition and Signaling -- The Collaborative Drug Discovery (CDD) Database -- Recognition of Nontrivial Remote Homology Relationships Involving Proteins of Helicobacter pylori: Implications for Function Recognition -- Identification of Novel Anthrax Toxin Countermeasures Using In Silico Methods -- Rational Design of HIV-1 Entry Inhibitors -- Malarial Kinases: Novel Targets for In Silico Approaches to Drug Discovery -- Designing Novel Inhibitors of Trypanosoma brucei -- Computational Models for Tuberculosis Drug Discovery.
  • 2013From: Springer Protocols
    edited by Maria Victoria Schneider.
    Systems biology can now be considered an established and fundamental field in life sciences. It has moved from the identification of molecular 'parts lists' for living organisms towards synthesising information from different 'omics'-based approaches to generate and test new hypotheses about how biological systems work. In Silico Systems Biology: Methods and Protocols, expert researchers in the field detail a practical set of chapters based often on actual materials used and develop for face-to-face training with examples and case studies.Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, step-by-step workflows, and key tips on troubleshooting and avoiding known pitfalls. -- Publisher website.
  • 2006From: CRCnetBASE
    edited by Darryl León, Scott Markel.
    Pattern matching / Scott Markel and Vinodh N. Rajapakse -- Tools for computational protein annotation and function assignment / Jaume M. Canaves -- The impact of genetic variation on drug discovery and development / Michael R. Barnes -- Mining of gene expression data / Aedin Culhane and Alvis Brazma -- Text mining / Bruce Gomes, William Hayes, and Raf Podowski -- Pathways and networks / Eric Minch and Ivayla Vatcheva -- Molecular interactions: learning from protein complexes / Ana Rojas, David de Juan, and Alfonso Valencia -- In silico siRNA design / Darryl León -- Predicting protein subcellular localization using intelligent systems / Rajesh Nair and Burkhard Rost -- Three-dimensional structures in target discovery and validation / Seán I. O'Donoghue, Robert B. Russell, and Andrea Schafferhans -- Comparative genomics / Viviane Siino, Bruce Pascal, and Christopher Sears -- Pharmacogenomics / Bahram Ghaffarzadeh Kermani -- Target identification and validation using human simulation models / Seth Michelson, Didier Scherrer, and Alex L. Bangs -- Using protein targets for in silico structure-based drug discovery / Tad Hurst -- Database management / Arek Kasprzyk and Damian Smedley -- BioIT hardware configuration / Philip Miller -- BioIT architecture: software architecture for bioinformatics research / Michael Dickson -- Workflows and data pipelines / Michael Peeler -- Ontologies / Robin A. McEntire and Robert Stevens.
    Also available: Print – 2006
  • 2011From: Springer Protocols
    edited by Bing Yu, Marcus Hinchcliffe.
    Accessing and selecting genetic markers from available resources / Christopher G. Bell -- Linkage analysis / Jennifer H. Barrett and M. Dawn Teare -- Association mapping / Jodie N. Painter, Dale R. Nyholt, and Grant W. Montgomery -- The ForeSee (4C) approach for integrative analysis in gene discovery / Yike Guo, Robin E.J. Munro, Dimitrios Kalaitzopoulos, and Anita Grigoriadis -- R statistical tools for gene discovery / Andrea S. Foulkes and Kinman Au -- In silico PCR analysis / Bing Yu and Changbin Zhang -- In silico analysis of the exome for gene discovery / Marcus Hinchcliffe and Paul Webster -- In silico knowledge and content tracking / Herman van Haagen and Barend Mons -- Application of gene ontology to gene identification / Hugo P. Bastos . [and others] -- Phenotype mining for functional genomics and gene discovery / Philip Groth, Ulf Leser, and Bertram Weiss -- Conceptual thinking for in silico prioritization of candidate disease genes / Nicki Tiffin -- Web tools for the prioritization of candidate disease genes / Martin Oti, Sara Ballouz, and Merridee A. Wouters -- Comparative view of in silico DNA sequencing analysis tools / Sissades Tongsima [and others] -- Mutation surveyor : an in Silico tool for sequencing analysis / Chongmei Dong and Bing Yu -- In silico searching for disease -- associated functional DNA variants / Rao Sethumadhavan, C. George Priya Doss, and R. Rajasekaran -- In silico prediction of transcriptional factor-binding sites / Dmitry Y. Oshchepkov and Victor G. Levitsky -- In silico prediction of splice-affecting nucleotide variants / Claude Houdayer -- In silico tools for qPCR assay design and data analysis / Stephen Bustin, Anders Bergkvist, and Tania Nolan -- RNA structure prediction / Stephan H. Bernhart -- In silico prediction of post-translational modifications / Chunmei Liu and Hui Li -- In silico protein motif discovery and structural analysis / Catherine Mooney [and others].
  • 2015From: Springer Protocols
    edited by Giselbert Hauptmann.
    Optimization of in situ hybridization and co-expression analysis in the central nervous system / Louisa Mezache ... [et al.] -- In situ hybridization methods for RNA visualization in C. elegans / Gina Broitman-Maduro and Morris F. Maduro -- Multicolored visualization of transcript distributions in Drosophila embryos / Iris Söll and Giselbert Hauptmann -- Exploring brain genoarchitecture by single and double chromogenic in situ hybridization (ISH) and immunohistochemistry (IHC) in whole-mount embryos / José Luis ... [et al.] -- Exploring brain genoarchitecture by single and double chromogenic in situ hybridization (ISH) and immunohistochemistry (IHC) on cryostat, paraffin, or floating sections / José Luis Ferran ... [et al.] -- Combined radioactive and nonradioactive double in situ hybridization (DISH) / Jong-Hyun Son and Ursula H. Winzer-Serhan -- One FISH, dFISH, three FISH : sensitive methods of whole- mount fluorescent in situ hybridization in freshwater planarians / David D. R. Brown and Bret J. Pearson -- Whole-mount in situ hybridization and immunohistochemistry in xenopus embryos / Edgar M. Pera ... [et al.] -- Manual and automated whole-mount in situ hybridization for systematic gene expression analysis in embryonic Zebrafish forebrain / Iris Söll and Giselbert Hauptmann -- Large-scale ISH on mouse brain sections for systematic gene expression analysis in developing mouse diencephalon / Tomomi Shimogori and Seth Blackshaw -- High-throughput in situ hybridization : systematical production of gene expression data and beyond / Lars Geffers and Gregor Eichele -- Analysis of embryonic gene expression patterns in the hagfish / Yasuhiro Oisi ... [et al.] -- Gene expression analysis of lamprey embryos / Fumiaki Sugahara, Yasunori Murakami, and Shigeru Kuratani -- Detection of mRNA and microRNA expression in basal chordates, amphioxus and ascidians / Simona Candiani, Greta Garbarino, and Mario Pestarino -- Analysis of gene expression in neurons and synapses by multi-color in situ hybridization / Leonid L. Moroz and Andrea B. Kohn -- Fluorescent in situ hybridization in primary hippocampal neurons to detect localized mRNAs / Jacki E. Heraud-Farlow, Tejaswini Sharangdhar, and Michael A. Kiebler -- Combining whole-mount in situ hybridization with neuronal tracing and immunohistochemistry / Jeremy S. Duncan ... [et al.] -- Fluorescent in situ hybridization detection of microRNAs in Newt tissue cryosections / Jamie Ian Morrison -- Subcellular transcript localization in Drosophila embryos and tissues visualized by multiplex-FISH / Julie Bergalet ... [et al.] -- Application of alkaline phosphatase-mediated azo dye staining for dual fluorescent in situ hybridization in Zebrafish / Giselbert Hauptmann, Gilbert Lauter, and Iris Söll -- Multiplex fluorescent RNA in situ hybridization via RNAscope / Hongwei Wang ... [et al.] -- Quantum dot-based in situ hybridization and immunohistochemistry to detect mRNA and protein at subcellular levels, comparison with studies using electron microscopy / Akira Matsuno ... [et al.] -- Quantitative multiplexed quantum dot based in situ hybridization in formalin-fixed paraffin-embedded tissue / Eleni Tholouli, Judith A. Hoyland, and Richard J. Byers -- Single and multiplexed fluorescent in situ hybridization using quantum dots nanocrystals in xenopus / Andriani Ioannou ... [et al.] -- Quantitative single-molecule mRNA fluorescent in situ hybridization in C. elegans / Remco A. Mentink ... [et al.] -- In situ detection of individual mRNA molecules with padlock probes and target-primed rolling-circle amplification in fixed mouse brain tissues / Thomas Hauling ... [et al.] -- Extended multiplexed fluorescent in situ hybridization by combinatorial encoding of individual transcripts / Lars Martin Jakt and Satoko Moriwaki -- Characterizing cellular identity at one cell resolution / Amaresh K. Ranjan, Mugdha V. Joglekar, and Anandwardhan A. Hardikar -- Transglutaminase-mediated in situ hybridization (TransISH) for mRNA detection in mammalian tissues / Katsuyuki Miyawaki, Sumihare Noji, and Noriho Kamiya -- ECHO-FISH for gene transcript detection in neuronal and other cells and subcellular compartments / Dan Ohtan Wang and Akimitsu Okamoto.
  • 2014From: Springer Protocols
    edited by Boye Schnack Nielsen, Bioneer A/S, Molecular Histology, Hørholm, Denmark.
    "In Situ Hybridization Protocols, Fourth Edition contains 21 protocols that utilize the in situ hybridization technology to document or take advantage of the visualization of specific RNA molecules. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, In Situ Hybridization Protocols, Fourth Edition seeks to aid scientists in the further discovery of new RNA species and uncovering of their cellular functions."--Page [4] of cover.
  • 2013From: Springer
    Andrew W. Artenstein.
    1. Origins -- 2. The Art and Science of Germs -- 3. A Singular Disease -- 4. A Very Mortal Disease -- 5. Early Approaches at Therapy -- 6. Antibiotics and Survival of the Fittest -- 7. A Brief History of Vaccines -- 8. That Soluble Specific Substance -- 9. Towards a Vaccine -- 10. Success for Half -- 11. The Future of a Killer.
  • Danai Papadatou.
    Society, science, and death -- A relationship of care -- Distinct features of the helping relationship -- The accompanying process -- The wounded healer -- A model for professionals' grieving process -- The rewards of caregiving -- Caregiving organizations and death -- Team functioning in death situations -- The good-enough team -- The challenges of educating health care professionals -- Epilogue -- Appendix: Brief description of Bowlby's theory on attachment.
  • Laurie Edwards.
    PrintStatus: Not Checked OutLane Catalog Record
    "Thirty years ago, Susan Sontag wrote, "Everyone who is born holds dual citizenship in the kingdom of the well and the kingdom of the sick ... Sooner or later each of us is obliged, at least for a spell, to identify ourselves as citizens of that other place." Now more than 133 million Americans live with chronic illness, accounting for nearly three-quarters of all health care dollars, and untold pain and disability. There has been an alarming rise in illnesses that defy diagnosis through clinical tests or have no known cure. Millions of people, especially women, with illnesses such as irritable bowel syndrome, chronic pain, and chronic fatigue syndrome face skepticism from physicians and the public alike. And people with diseases as varied as cardiovascular disease, HIV, certain cancers, and type 2 diabetes have been accused of causing their preventable illnesses through their lifestyle choices. We must balance our faith in medical technology with awareness of the limits of science, and confront our throwback beliefs that people who are sick have weaker character than those who are well. Through research and patient narratives, health writer Laurie Edwards explores patient rights, the role of social media in medical advocacy, the origins of our attitudes about chronic illness, and much more. What The Noonday Demon did for people suffering from depression, In the Kingdom of the Sick does for those who are chronically ill"--Provided by publisher.
  • 2013From: ProQuest Ebook Central
    Ruth Horowitz.
    Public member, researcher, and public sociologist -- How licensure became a medical institution -- The Federal bureaucracy starts a public dialogue -- The state, the media, and the shaping of public opinion -- Rhetorics of law, medicine, and public interest shape board work -- Medical and legal discourses in investigatory committees -- Hearing and sanction deliberations : transparency and fact construction issues -- Democratic deliberation and public interest.
  • 2008From: Springer
    Masood Zangeneh, Alex Blaszczynski, Nigel E. Turner, editors.
    Introduction / Masood Zangeneh, Alex Blaszczynski and Nigel E. Turner -- Explaining Why People Gamble / Michael Walker, Tony Schellink, and Fadi Anjoul -- Games, Gambling, and Gambling Problems / Nigel E. Turner -- Exploring the Mind of the Gambler / Ewa Czerny, Stephanie Koenig, and Nigel E. Turner -- Individual Factors in the Development and Maintenance of Problem Gambling / Masood Zangeneh, Alex Grunfeld, and Stephanie Koenig -- Gambling / Lisa Cavion, Carol Wong, and Masood Zangeneh -- A Critical Perspective on Gambling / Amnon Jacob Suissa -- The Marketing of Gambling / Masood Zangeneh, Mark Griffiths, and Jonathan Parke -- Religiosity and Gambling Rituals / Robert Grunfeld, Masood Zangeneh, and Lea Diakoloukas -- Buying a Risk / G. E. Minchin -- Cognitive Behavioral Therapy for Problem Gamblers / Malcolm Battersby, Jane Oakes, Barry Tolchard, Angus Forbes, and Rene Pols -- Psychopharmacological Management of Pathological Gambling / Jon E. Grant, Suck Won Kim, and Marc N. Potenza -- A Transpersonal Developmental Approach to Gambling Treatment / Gary Nixon and Jason Solowoniuk -- How Science Can "Think" About Gamblers Anonymous / Peter Ferentzy and Wayne Skinner -- Problem Gambling and Anger: Integrated Assessment and Treatment / Lorne M. Korman, Emily Cripps, and Tony Toneatto -- A Treatment Approach for Adolescents with Gambling Problems / Rina Gupta and Jeffrey Derevensky -- The Evolution of Problem Gambling Helplines / Gary Clifford.
  • Huibin Zhang.
    MicroRNAs are an important class of short RNA molecules that regulate gene expression in diverse organisms. Despite their short history, extensive research on microRNAs has revealed how microRNAs are made, their regulatory mechanisms and functions in different biological processes. In addition, novel experimental techniques and computational algorithms have been developed to study microRNAs. Our knowledge of microRNAs is constantly evolving as newer studies turn up exceptions to canonical models established by early studies. This highlights how our understanding of microRNAs is far from complete and much work is still needed to investigate unexplored aspects of the microRNA world. The founding microRNAs, C. elegans lin-4 and let-7, have well-characterized heterochronic defects in mutant animals and their target genes have been genetically validated. Combined with powerful experimental tools available in C. elegans, the microRNA function of lin-4 and let-7 in developmental timing of C. elegans is an ideal in vivo model system for testing microRNA-related hypotheses. Using functional assays to evaluate lin-4 and let-7 rescue activities in transgenic animals, we have investigated several poorly understood aspects of microRNAs, from biogenesis to functional mechanism. In this work, we first demonstrated the cell autonomous nature of lin-4 in C. elegans temporal development. Through tissue/cell-specific expression of lin-4 and the use of tissue/cell-specific reporters and microRNA sponges, we have shown that lin-4 rescue activities were limited to sites of lin-4 expression, despite its broad endogenous expression and function in many tissues. Next, we showed that intron-containing microRNAs ("inc-miRs") are functional in C. elegans, raising the possibility that mature microRNAs need not be encoded as contiguous units in the genome. This result also highlights a blindspot in our current novel microRNA discovery methods that assume inc-miRs do not exist. Lastly, we investigated the partnership between microRNA "seed" and "non-seed" sequences in providing microRNA function during C. elegans temporal development. By assessing microRNA function in transgenic mutant animals expressing lin-4 or let-7 mutant microRNA, we found contrasting results between lin-4 and let-7. While the results suggest a functional requirement for lin-4 seed sequence, mutations in either let-7 seed or non-seed sequences provided similar levels of functional activities. Using C. elegans lin-4 and let-7 as an experimental model, this work has furthered our understanding on microRNA autonomy, microRNA biogenesis and functional partnership between microRNA seed and non-seed sequence.
  • edited by Ajay Major & Aleena Paul.
    PrintStatus: Not Checked OutLane Catalog Record
    Hands/ Lisa Moore -- Stripping down the flesh / Nita Chen -- EKG calamity / Steven Lange -- Lacrimos / Daniel Coleman -- Autumn autopsy / Abi Ashcraft -- A tub of baby hearts / Katie Taylor -- Anatomical variation / Damien Zreibe -- Hello sir / Haikoo Shah -- I don't know : the medical student motto / Daniel Lefler -- Medicine's hardest lesson : people, not patients / Navdeep Kang -- Searching for role models in medicine / David Gasalberti -- It's hard keeping a white coat clean / Claire McDaniel -- Medical student, student physician or student doctor? / Joshua Niforatos -- On empathy (can these shoes ever fit?) / Jennifer Hong -- Learning to see / Olivia Low -- 30 percent bucket / Joshua Stein -- On clinical teaching and evidence-based medicine / Amy Briggs -- The value of empathy in medicine / Sarah Bommarito -- "May I ask you a few questions and examine you?" / Tania Tabassum -- Overthink it! / Eric Donahue -- Eau de medical school / Nita Chen -- Doctor Dad : a husband and father of three / Daniel Gates -- Better mom, better doctor / Mariya Cherneykina -- Never forget those who got you here / Eric Donahue -- Being pregnant during the first year of medical school / Allison Lyle -- For Pappou : a reflection on loss / Chris Meltsakos -- Medical student as patient / Lorenzo Sewanan -- When a patient's disease strikes a chord / Anjani Amladi -- Parenthesis / Amanda Rutishauser -- A medical student's experience as a patient / Crystal Romero -- Treating the disease and treating the illness / Steven Lange -- Broken / Jennifer Tsai -- A night at the homeless shelter / Jimmy Tam Huy Pham -- A wait for the bus : a solution for wandering in dementia / Katie Taylor -- How health care policy shapes health care practice / Manasa Mouli -- A lack of care : why medical students should focus on Ferguson / Jennifer Tsai -- Physicians-in-transit : the blizzard of 2015 / Jacob Walker -- My black eyes / Jessicqa Ubanyionwu -- Mine / Damien Zreibe -- On silence : the limits of professionalism / Jennifer Hong -- My white coat costume / Jes Minor -- Street medicine / Ajay Koti -- The chair / Ben Ferguson - My contribution / Kerri Vincenti -- Don't judge a book by its cover / Manik Aggarwal -- To the man with the flowers / Sasha Yakhkind -- The little one / Eric Ballon-Landa -- Exam room 3 / Jimmy Yan -- Emotions and energy in the ICU / Lisa Moore -- A sweet embrace / Zachary Abramson -- Do you remember? / Jimmy Yan -- Beta amyloid blues / Kiersten Pollard -- A story of love from psychiatry / Manasa Mouli -- Eyes : a reflection from the first month of clerkships / Sanjay Salgado -- We lost it : a story of surgical error / Dacia Russell -- How to make challah : the Jewish octopus / Ajay Koti -- Why I am in the room / Katie Taylor -- Fading memories of love and martinis / Joshua Niforatos / M/R/G / Steven Lange -- The lady in red / Lisa Podolsky -- Being there / Corbin Pomeranz -- A portrait of the patient as an old man / Millin Sekhon -- Pansies, rosemary and rue / Erin Baumgartner -- Diversity and rhinos / Bianca Maria Stifani -- Medicine, meaning and fluency / Jocelyn Mary-Estelle Wilson -- On doctoring etiquette / Qing Meng Zhang -- A patient in denial : is the system at fault? / Ola Hadaya -- Clinical culture shock : low health literacy as a barrier to effective communication / Lindsey McDaniel -- Talking dirty / Mariya Cherneykina -- Lost in translation / Katharine Caldwell -- View from the other side / Jimmy Yan -- Doctoring : who is it really for? / Nita Chen -- Breaking down the barrier / Pratik Kanabur -- A case for inclusive language / Ria Pal -- Remembering what it is like not to know / Katie Taylor -- How medical school taught me to put studying second / Samuel Scott -- Do they teach fear in medical school? / Ajay Koti -- Idea worship : mindfulness in medical school / Andrew Kadler -- How to find the strength to keep going : words of advice from a third-year / Jarna Shah -- Wounded healers / Ajay Koti -- Rite of passage / Nita Chen -- Booster / Jennifer Tsai -- CMO : comfort measures only, not morphine drip only / Reza Hosseini Ghomi -- From birth to death : a recollection of the third year / Chris Meltsakos -- The inevitable / Punita Shroff -- Life song / Sophia Tolliver -- False song? The story of Mr. R. / Faryal Osman -- Try again : experiencing failure as a medical student / Sadhana Rajamoorthi -- Stars, dollar bills and other essentials / Morgan Shier -- Breeze / Jennifer Tsai -- N'ap kenbe/we're holding on / Christopher Hudson -- Half of a year, halfway across the world / Sadhana Rajamoorthi -- The problem with playing doctor / Shraddha Dalwadi -- Perspectives from the bike : a look at an Ecuadorian hospital / Brian Lefchak -- An afternoon with a Swazi boy / Brent Schnipke -- On a mission / Victoria Psomiadis -- More than a number : the patient's story / Peter Wingfield -- On becoming a doctor : excellent medical student, terrible clinician / Amy Ho -- A letter to myself, future resident, on dealing with myself, current medical student / Lindsay Heuser -- "Are there any physicians on board, we have a medical emergency" / Manik Aggarwal --Is it better to trust or to hope? / Robert Ethel.
  • Carissa Bove Meyer.
    Eukaryotic chromosomes segregate by attaching to microtubules of the mitotic spindle through a chromosomal microtubule-binding site called the kinetochore. Kinetochores assemble on a specialized chromosomal locus termed the centromere, characterized by the replacement of histone H3 in centromeric nucleosomes with the essential histone H3 variant centromere protein A (CENP-A). CENP-A nucleosomes are believed to epigenetically specify centromere identity, thus understanding how CENP-A chromatin is assembled and maintained is central to understanding chromosome segregation mechanisms. CENP-A nucleosome assembly requires the Mis18 complex and the CENP-A chaperone HJURP. HJURP binds to pre-nucleosomal CENP-A and facilitates the deposition of new CENP-A nucleosomes into centromeric chromatin. The mechanistic roles of the Mis18 complex in CENP-A assembly and maintenance are not well understood. The Mis18 complex and HJURP localize to centromeres in telophase/G1, when new CENP-A chromatin is assembled. The molecular interactions that control their targeting are unknown. Several constitutive centromere proteins that remain associated with CENP-A chromatin throughout the cell cycle have also been implicated in CENP-A assembly, including CENP-C. Their functions in CENP-A assembly are unknown. The first chapter of this thesis work describes the development of an in vitro system for centromeric chromatin assembly in Xenopus laevis egg extracts. We show that CENP-A assembly in extract recapitulates the cell cycle dependence and HJURP requirement of CENP-A assembly in somatic cells. We then use this in vitro system to identify a novel role for CENP-C in recruiting CENP-A assembly factors to the centromere to promote CENP-A assembly, described in Chapter 2. We show that CENP-C is required to target the Mis18 complex protein M18BP1 to Xenopus sperm centromeres in metaphase. In the absence of CENP-C, M18BP1 and HJURP targeting to centromeres is disrupted and new CENP-A assembly into centromeric chromatin is inhibited. We find that CENP-C interacts directly with M18BP1 through conserved domains in the CENP-C protein. Thus, CENP-C provides a link between existing CENP-A chromatin and the proteins required for new CENP-A nucleosome assembly. Overall, this work extends our mechanistic understanding of how the pre-existing centromere directs the local assembly of new CENP-A nucleosomes to ensure stable propagation of the centromere. Furthermore, the ability to assemble centromeric chromatin in vitro will provide a valuable tool for dissecting the biochemical and cell cycle regulatory mechanisms that control new CENP-A assembly and ensure faithful centromere propagation.
  • Michael Quay Chen.
    The limited ability of the human heart to regenerate has made myocardial infarction and heart failure debilitating conditions. Recently, an approach using pluri- or multi-potent stem cells to repair damaged heart tissue is being explored for its potential to regenerate tissue as a tailored, patient-specific treatment. However, the mechanisms of integration remain unclear, and many cardiac grafting procedures utilizing both embryonic and adult stem cells have been met with limited success. While current evidence suggests that grafts are likely viable in host myocardium, clinical studies have reported pro arrhythmic side-effects following transplantation, which arise from disrupted propagation patterns. These issues may be attributed to grafts lacking cardiac differentiation, or possessing conduction properties inconsistent with the host tissue. Consequently, understanding the role of the electrical environment throughout the engraftment process is necessary, but infeasible due to a lack of proper tools. Elucidating the electrical aspects of stem cell transplantation aims to ensure proper integration of the transplanted cells to prevent aberrant electrical pathways in the heart. In this work, a set of in vitro tools were developed to study the potential mechanisms underlying the risk of arrhythmia following stem cell transplantation. A planar microelectrode array was first used to investigate the possibility of conduction block if undifferentiated or non cardiomyocyte stem cells, such as mesenchymal stem cells, are used as grafts. Conduction in murine cardiomyocytes was purposely blocked by co-culture with non-conducting murine fibroblasts, and a novel mathematical transform known as a co occurrence matrix was developed to quantitatively analyze the uniformity of conduction. The observed sensitivity of cardiomyocyte conduction illustrated the risk of grafting non-cardiomyocyte cell types despite any potential of differentiating into muscle-like cells. Unlike non-conducting fibroblasts, stem cell grafts are expected to electrically conduct if proper cardiac differentiation takes place. However, possible differences in the conduction properties of these grafts may still lead to arrhythmia. To perform a controlled study of such conduction mismatch, an in vitro co-culture system coupled to microelectrode arrays was developed. Spatially separated cultures representing the host and the graft were allowed to gradually merge above the microelectrode array, allowing the measurement of conduction throughout the integration process. Modeled host and graft cell populations were evaluated by analyzing the co occurrence matrix and conduction velocity for the quality and speed of conduction over time. Co cultures between murine cardiomyocytes (host) and murine skeletal myoblasts (graft) exhibited significant differences in conduction despite synchronous electrical activity. In contrast, conduction was well matched when the same host cells were co cultured with murine embryonic stem cells (mESC). A model using murine cardiomyocytes (host) and differentiating human embryonic stem cells (graft) allowed the characterization of conduction properties relevant to current trans-species animal models, and demonstrate the co-culture device as a screening platform for candidate graft cells. The limited region of the graft that supported conduction exhibited differences in the co-occurrence matrix as well as conduction velocity when compared to the host region. In an effort to improve the effects of conduction mismatch, both host and graft cell populations were electrically paced over the length of time the cultures remained viable (4-5 days). Although a difference between conduction velocities between host and graft was still observed, the overall uniformity of conduction improved in paced co-cultures, implying increased cardiac differentiation. A preliminary study of genomic changes due to paced mESCs resulted in a significant upregulation of several important cardiac genes and a significant downregulation of many embryonic genes. Further efforts are currently underway to examine gene expression with paced hESCs to optimize integration in the host-graft model, and ultimately to understand how the electrical environment influences stem cell transplantation.
  • Ethan Oblivion Kung.
    Biomechanical forces such as hemodynamic parameters and stress and strain in blood vessel walls have significant effects on the initiation and development of cardiovascular diseases, as well as on the operations of implantable medical devices. Computational fluid dynamics is an emerging powerful numerical tool capable of providing fine temporal and spatial resolutions in the quantifications of these cardiovascular biomechanical forces. The overall goal of this research is to develop tools and methods for conducting in-vitro experiments, and to acquire experimental data for the validation of the computational methods. We first developed a physical Windkessel module which can provide realistic vascular impedances at the outlets of flow phantoms in order to enable in-vitro experiments that mimic in-vivo conditions. We also defined a corresponding analytical model of the Windkessel module, and showed that upon proper characterization, the analytical model can accurately predict the pressure and flow relationships produced by the physical Windkessel module. The precise analytical model can then be prescribed as a boundary condition for the finite element domain, resulting in a direct parallel between the computational description of the physical model and the physical reality. We then performed validation of the numerical method using the Windkessel module, and a rigid, two outlet, patient-derived abdominal aortic aneurysm phantom under resting and light exercise flow and pressure conditions. Physiological pressures within the phantom, and flow waveforms through the two phantom outlets were achieved. Finally, we performed validation of the numerical method incorporating deformable vessel walls, using two compliant flow phantoms under physiological flow, pressure, and deformation conditions. The compliant phantoms mimicked a patent thoracic aorta, and one with an 84% coarctation (by area). The computational predictions of pressure, flow, and velocity patterns compared favorably with experimental measurements in both of the validation studies. The accurate prediction of wave propagation behaviors in the deformable phantom study indicated a faithful prediction of the vessel wall motion. In addition to numerical methods validation, the experimental techniques we have developed can also be used in direct in-vitro evaluations of medical devices.
  • 2012From: Springer
    Elizabeth S. Ginsburg, Catherine Racowsky, editors.
    In Vitro Fertilization: A Comprehensive Guide represents the next frontier in the integrated clinical and laboratory practice of ART. Uniquely balanced, the book provides the necessary understanding of the key laboratory techniques involved in ART and the complex aspects of clinical care. Featuring the contributions of world leaders in the field, the guide begins with the evaluation of the infertile woman and man. It then moves on to discuss treatment protocols and adjunctive treatments. Techniques for oocyte retrieval and insemination, embryo culture and transfer, and micromanipulation procedures are explored in detail. This comprehensive book covers all aspects of IVF and includes special sections on oocyte and embryo donation as well as gestational carriers, making it ideal for practicing clinicians. Advances such as pre-implantation genetic diagnosis and screening, in vitro maturation, and means of fertility preservation, including oocyte and ovarian tissue cryopreservation, are also covered. The book concludes with dedicated chapters on quality assessment and improvement, regulation and legal concerns, and stress and ART. Readers will gain complete in-depth knowledge of the most current therapies and techniques, enabling optimal care and counsel of their infertile patients.
  • editor, Mukta M. Webber ; associate editor, Lea I. Sekely.
    PrintStatus: Not Checked OutLane Catalog Record
    v. 1. Carcinomas of the esophagus and colon.--v. 2. Carcinomas of the liver and pancreas.--v. 3. Carcinomas of the mammary gland, uterus, and skin.--v. 4. Carcinomas of the urinary bladder and kidney.--v. 5. Carcinoma of the prostate and testis.
  • 2010From: Springer Protocols
    edited by Jeff Braman.
    Mutagenesis protocols in Saccharomyces cerevisiae by in vivo overlap extension / Mibuel Alcalde -- In vitro mutagenesis of Brucella species / Thomas A. Ficht, Jianwu Pei, and Melissa Kahl-McDonagh -- Random mutagenesis strategies for Campylobacter and Helicobacter species / Duncan J.H. Gaskin and Arnoud H.M. van Vliet -- Mutagenesis of the repeat regions of herpesviruses cloned as bacterial artificial chromosomes / Yuguang Zhao and Venugopal Nair -- An efficient protocol for VZV BAC-based mutagenesis / Zhen Zhang, Ying Huang, and Hua Zhu -- A method for rapid genetic integration into Plasmodium falciparum utilizing mycobacteriophage Bxb1 integrase / Sophie H. Adjalley, Marcus C.S. Lee, and David A. Fidock -- Random mutagenesis by error-prone PCR / Elizabeth O. McCullum ... [et al.] -- A rapid and versatile PCR-based site-directed mutagenesis protocol for generation of mutations along the entire length of a cloned cDNA / Vincent Dammai -- Rapid sequence scanning mutagenesis using in silico oligo design and the megaprimer PCR of whole plasmid method (MegaWhop) / Urich Krauss, Karl-Erich Jaeger, and Thorsten Eggert -- Insertion and deletion mutagenesis by overlap extension PCR / Jehan Lee ... [et al.] -- Targeted amplification of mutant strands for efficient site-directed mutagenesis and mutant screening / Lei Young and Qihan Dong -- A modified inverse PCR procedure for insertion, deletion, or replacement of a DNA fragment in a target sequence and its application in the ligand interaction scan method for generation of ligand-regulated proteins / Oran Erster and Moti Liscovitch -- Amplification of orthologous genes using degererate primers / Samya Chakravorty and jim O. Vigoreaux -- Computational evaluation of protein stability change upon mutations / Shuangye Yin, Feng Ding, and Nikolay V. Dokholyan -- Approaches for using animal models to identify loci that genetically interact with human disease-causing point mutations / Josef D. Franke -- Using peptide loop insertion mutagenesis for the evolution of proteins / Christian Heinis and Kai Johnsson -- Massive mutagenesis : high-throughput combinatorial site-directed mutagenesis / Julien Sylvestre -- Directed in vitro evolution of reporter genes based on semi-rational design and high-throughput screening / Ai-Sheng Xiong ... [et al.] -- Ribosome display for rapid protein evolution by consecutive rounds of mutation and selection / Hayato Yanagida, Tomoaki Matsuura, and Tetsuya Yomo -- Fine-tuning enzyme activity through saturation mutagenesis / Holly H. Hogrefe -- Characterization of structural determinants of type 1 corticotropin releasing hormone (CRH) receptor signalling properties / Danijela Markovic and Dimitris K. Grammatopoulos -- Site-directed mutagenesis for improving biophysical properties of Vh domains / Mehdi Arbabi-Ghahroudi, Roger MacKenzie, and Jamshid Tanha -- Phenotype based functional gene screening using retrovirus-mediated gene trapping in quasi-haploid RAW 264.7 cells / Sung Ouk Kim and Soon-Duck Ha -- Site-directed disulfide cross-linking to probe conformational changes of a transporter during its functional cycle : Escherichia coli AcrB multidrug exporter as an example / Yumiko Takatsuka and Hiroshi Nikaido -- Site-specific incorporation of extra components into RNA by transcription using unnatural base pair systems / Michiko Kimoto and Ichiro Hirao -- Mutagen : a random mutagenesis method providing a complementary diversity generated by human error-prone DNA polymerases / Philippe Mondon ... [et al.] -- Random-scanning mutagenesis / Robert A. Smith -- Easy two-step method for randomizing and cloning gene fragments / Vivan Q. Zhang and Holly H. Hogrefe -- Random mutagenesis using a mutator strain / Ghazala Muteeb and Ranjan Sen -- En passant mutagenesis : a two step markerless red recombination system / B. Karsten Tischer, Gregory A. Smith, and Nikolaus Osterrieder.
  • 2011From: Springer Protocols
    edited by Lucio G. Costa, Gennaro Giordano, Marina Guizzetti.
    In vitro neurotoxicology : an introduction / Lucio G. Costa, Gennaro Giordano, and Marina Guizzetti -- Primary neurons in culture and neuronal cell lines for in vitro neurotoxicological studies / Gennaro Giordano and Lucio G. Costa -- Determination of metal interactions with the chaperone Hspa5 in human astrocytoma cells and rat astrocyte primary cultures / Evelyn Tiffany-Castiglioni [and others] -- Microglia cell culture: a primer for the novice / Anke Witting and Thomas Möller -- Neural stem cells for developmental neurotoxicity studies / Roshan Tofighi [and others] -- Preparation, maintenance, and use of serum-free aggregating brain cell cultures / Paul Honegger [and others] -- Neurospheres as a model for developmental neurotoxicity testing / Ellen Fritsche, Kathrin Gassmann, and Timm Schreiber -- Acute hippocampal slice preparation and hippocampal slice Cultures / Pamela J. Lein, Christopher D. Barnhart, and Isaac N. Pessah -- Glia-neuron sandwich cocultures : an in vitro approach to evaluate cell-to-cell communication in neuroinflammation and neurotoxicity / ariaserena Boraso and Barbara Viviani -- In vitro models to study the blood brain barrier / Hilary Vernon, Katherine Clark, and Joseph P. Bressler -- Measurements of cell death in neuronal and glial cells / Gennaro Giordano [and others] -- Measurements of neuronal apoptosis / Gennaro Giordano and Lucio G. Costa -- Measurement of isoprostanes as markers of oxidative stress / Dejan Milatovic, Thomas J. Montine, and Michael Aschner -- Assessment of glutathione homeostasis / Gennaro Giordano, Collin C. White, and Lucio G. Costa -- Assessing neuronal bioenergetic status / Stephanie L.H. Zeiger, Jeannette N. Stankowski, and BethAnn McLaughlin -- Fluorescent assessment of intracellular calcium in individual cells / David P. Cox, Collin C. White, and Terrance J. Kavanagh -- Homeostatic regulation of glutamate neurotransmission in primary neuronal cultures / Victor Briz and Cristina Suñol -- Detection of nitric oxide formation in primary neural cells and tissues / Ronald B. Tjalkens, David L. Carbone, and Guoyao Wu -- JNK3-mediated apoptotic cell death in primary dopaminergic neurons / Won-Seok Choi, Heather M. Klintworth, and Zhengui Xia -- Measurement of proteasomal dysfunction in cell models of dopaminergic degeneration / Faneng Sun, Anumantha G. Kanthasamy, and Arthi Kanthasamy -- Cell signaling and neurotoxicity : protein kinase C in vitro and in vivo / Prasada Rao S. Kodavanti -- Cell signaling and neurotoxicity : 3H-arachidonic acid release (phospholipase A2) in cerebellar granule neurons / Prasada Rao S. Kodavanti -- Quantitative assessment of neurite outgrowth in PC12 cells / Joshua A. Harrill and William R. Mundy -- Measurements of astrocyte proliferation / Marina Guizzetti, Terrance J. Kavanagh, and Lucio G. Costa -- Quantification of synaptic structure formation in cocultures of astrocytes and hippocampal neurons / Pamela J. Roqué [and others] -- Volume measurements in cultured primary astrocytes / Michael Aschner -- Assessment of cholesterol homeostasis in astrocytes and neurons / Jing Chen, Lucio G. Costa, and Marina Guizzetti -- Dose-response or dose-effect curves in in vitro experiments and their use to study combined effects of neurotoxicants / Matteo Goldoni and Sara Tagliaferri.
  • Stephen Jarrett Wrenn.
    PrintStatus: Not Checked OutLane Catalog Record
  • 2014From: Springer Protocols
    edited by Anna Bal-Price, Paul Jennings.
    In Vitro Toxicology Systems brings together important issues and considerations needed in order to develop a workable, reliable, integrated testing strategy for the replacement of animals in toxicity testing regimes. This thorough volume includes sections on in vitro models for systemic organ toxicity, neurotoxicity, sensory organs, immunotoxicity and reproductive toxicity and addresses how stem cells may be used going forward. The book also tackles difficult areas of toxicology such as carcinogenicity and nanotoxicology, with additional chapters dedicated to kinetics, metabolism, and in vitro in vivo extrapolation. The book also addresses biological processes such as stress response pathways and mechanistic biomarkers and how these can be uncovered and measured using high content approaches. Reliable and authoritative, In Vitro Toxicology Systems will be of benefit not only to students, scientists, and regulators working in the field of chemical safety assessment but also to a wider scientific audience.
  • 2007From: Springer Protocols
    edited by Guido Grandi.
    Energy systems for ATP regeneration in cell-free protein synthesis reactions / Kara A. Calhoun and James R. Swartz -- Continuous-exchange protein-synthesizing systems / Vladimir A. Shirokov ... [et al.] -- Cell-free production of integral membrane proteins on a preparative scale / Christian Klammt ... [et al.] -- SIMPLEX : a novel method for high-throughput construction and screening of protein libraries / Suang Rungpragayphan, Tsuneo Yamane, and Hideo Nakano -- Methods for high-throughput materialization of genetic information based on the wheat germ cell-free expression system / Tatsuya Sawasaki ... [et al.] -- Exogenous protein expression in Xenopus oocytes : basic procedures / Elena Bossi ... [et al.] -- In vitro translation to study HIV protease activity / Zene Matsuda ... [et al.] -- The protein truncation test in mutation detection and molecular diagnosis / Oliver Hauss and Oliver Muller -- Creation of novel enantioselective lipases by SIMPLEX / Yuichi Koga, Tsuneo Yamane, and Hideo Nakano -- In vitro transcription and translation coupled with two-dimensional electrophoresis for bacterial proteome analysis / Nathalie Norais ... [et al.] -- In vitro screen of bioinformatically selected Bacillus anthracis vaccine candidates by coupled transcription, translation, and immunoprecipitation analysis / Orit Gat, Haim Grosfeld, and Avigdor Shafferman -- Functional expression of Type 1 rat GABA transporter in microinjected Xenopus laevis oocytes / Stefano Giovannardi ... [et al.] -- Production of protein for nuclear magnetic resonance study using the wheat germ cell-free system / Toshiyuki Kohno and Yaeta Endo.
  • 2012From: Springer Protocols
    edited by Robert M. Hoffman.
    Assessing Cancer Cell Migration and Metastatic Growth In Vivo in the Chick Embryo Using Fluorescence Intravital Imaging / Hon Sing Leong, Ann F. Chambers, and John D. Lewis -- The Use of Fluorescent Proteins for Intravital Imaging of Cancer Cell Invasion / James Hulit, Dmitriy Kedrin, Bojana Gligorijevic, David Entenberg, Jeffrey Wyckoff, John Condeelis, and Jeffrey E. Segall -- High-Resolution In Vivo Imaging of Fluorescent Proteins Using Window Chamber Models / Gregory M. Palmer, Andrew N. Fontanella, Siqing Shan, and Mark W. Dewhirst -- In Vivo Imaging of Pancreatic Cancer with Fluorescent Proteins in Mouse Models / Michael Bouvet and Robert M. Hoffman -- Lentivirus-Based DsRed-2-Transfected Pancreatic Cancer Cells for Deep In Vivo Imaging of Metastatic Disease / Zeqian Yu, Jiahua Zhou, and Robert M. Hoffman -- Noninvasive and Real-Time Fluorescence Imaging of Peritoneal Metastasis in Nude Mice / Hayao Nakanishi, Seiji Ito, Makoto Matsui, Yuichi Ito, Kazunari Misawa, and Yasuhiro Kodera -- Three-Dimensional In Vivo Imaging of Tumors Expressing Red Fluorescent Proteins / Alexander P. Savitsky, Irina G. Meerovich, Victoria V. Zherdeva, Lyaysan R. Arslanbaeva, Olga S. Burova, Darina V. Sokolova, Elena M. Treshchalina, Anatoly Yu Baryshnikov, Ilya I. Fiks, Anna G. Orlova, Michael S. Kleshnin, Ilya V. Turchin, and Alexander M. Sergeev -- Real-Time Visualization and Characterization of Tumor Angiogenesis and Vascular Response to Anticancer Therapies / H. Rosie Xing and Qingbei Zhang -- In Vivo Imaging of Human Cancer with Telomerase-Specific Replication-Selective Adenovirus / Toshiyoshi Fujiwara -- Real-Time Fluorescence Imaging of Abdominal, Pleural, and Lymphatic Metastases / Susanne Carpenter and Yuman Fong -- Real-Time Imaging of Tumors Using Replication-Competent Light-Emitting Microorganisms / Yong A. Yu, Stephanie Weibel, and Aladar A. Szalay -- GFP-Transgenic Animals for In Vivo Imaging: Rats, Rabbits, and Pigs / Takashi Murakami and Eiji Kobayashi -- The Use of Fluorescent Proteins for Developing Cancer-Specific Target Imaging Probes / Thomas E. McCann, Nobuyuki Kosaka, Peter L. Choyke, and Hisataka Kobayashi -- In Vivo Imaging of the Developing Mouse Embryonic Vasculature / Irina V. Larina and Mary E. Dickinson -- Screening Reef Corals for Novel GFP-Type Fluorescent Proteins by Confocal Imaging / Anya Salih -- What Does It Take to Improve Existing Fluorescent Proteins for In Vivo Imaging Applications? / Marc Zimmer -- In Vivo Imaging of Oligonucleotide Delivery / Fumitaka Takeshita, Ryou-u Takahashi, Jun Onodera, and Takahiro Ochiya -- Subcellular Imaging In Vivo: The Next GFP Revolution / Robert M. Hoffman.
  • Lia Eun Hee Gracey.
    The pursuit of gene therapy to treat a wide-spectrum of diseases holds great promise, but its application in the clinic is still blocked by several barriers. Gene therapy approaches that rely on a virus to carry genetic material are plagued by problems with a host immune response and difficulty reaching therapeutic doses. Nonviral approaches have the advantage that delivering naked DNA does not illicit the same significant immune response and therapeutic levels are often initially easily attained. But, one prominent barrier to nonviral gene therapy is the lack of in vivo sustained expression from a foreign transgene. In the early stages after delivery, robust expression can be achieved from transgenic DNA, but this expression is very quickly and efficiently silenced, with loss of the desired effect of gene replacement. Our work took a two-step approach to further our understanding of how to create a better expression vector, both for gene therapy purposes as well as basic scientific goals of sustaining expression from delivered transgenic DNA. First, we studied whether we could manipulate and control the chromatin structure that a delivered gene adopts in vivo via nucleosome positioning signals on plasmid DNA in mouse liver. We developed a selective hybridization assay that allowed us to use a high-throughput sequencing approach to more rapidly screen the nucleosome occupancy and positioning of numerous constructs with varied DNA elements. We were able to transiently control the initial chromatin structure, but other forces in the cell soon overcame the thermodynamic preferences of nucleosome formation. We now believe that the use of nucleosome eviction elements may be a more promising approach: it will likely be more feasible to exclude nucleosome formation using rigid DNA sequences instead of permanently positioning a nucleosome using DNA sequence alone. Secondly, we gained a more fundamental understanding of the mechanism(s) responsible for the silencing of episomal (non-integrating) DNA constructs in mouse liver. We studied the differences between plasmid DNA and minicircle DNA, which was derived from a parental plasmid but lacked bacterial backbone sequences. At 6 weeks after delivery, plasmid DNA was effectively silenced but there was still active expression from the minicircle. We used high-throughput sequencing approaches to quantitate the levels of transcription and the enrichment of various histone modifications and RNA polymerase II (Pol II) on plasmid and minicircle. We found that Pol II appeared to stall at the transcription start site on the plasmid but was present at the 5' and 3' ends of the gene on the minicircle. This observation may explain the 28-fold higher level of transcript produced by the minicircle versus the plasmid. Though we saw enrichment of activating and silencing histone modifications on both plasmid and minicircle (likely due to our analysis of a population of cells which at any given point could have a construct that is actively expressed or silenced) we observed a striking abundance of a well-characterized histone modification associated with silencing on the plasmid and not on the minicircle. These results represent a contribution to the fields of gene therapy and chromatin biology that will help us move in the direction of achieving safe, therapeutic, and sustained expression of transgenic DNA.
  • 2016From: Springer
    Shinichi Ohno, Nobuhiko Ohno, Nobuo Terada, editors.
  • 2007From: Springer
    edited by Anthony F. Shields and Pat Price.
  • 2006From: Springer
    edited by Herman Friedman, Steven Specter, Mauro Bendinelli.
  • v. 1-2, 2006.From: Springer
    Fulltext (v. 2)From: Springer
    Christopher S. Stevenson, Lisa A. Marshall, Douglas W. Morgan, editors.
    Also available: Print – v. 1-2.
  • 2011From: Springer Protocols
    edited by Leif Schröder, Cornelius Faber.
    Physical basics of NMR / Rolf Pohmann -- Spatial encoding-basic imaging sequences / Rolf Pohmann -- Basic contrast mechanisms / Leif Schröder and Cornelius Faber -- Scanner components / Volker C. Behr -- Small animal preparation and handling in MRI / Patrick McConville -- Cerebral perfusion MRI in mice / Frank Kober, Guillaume Duhamel, and Virginie Callot -- High field diffusion tensor imaging in small animals and excised tissue / Bernadette Erokwu, Chris Flask, and Vikas Gulani -- BOLD effect / Joan M. Greve -- Screening of CEST MR contrast agents / Xiaolei Song, Kannie W.Y. Chan, and Michael T. McMahon -- Hyperpolarized noble gases as contrast agents / Xin Zhou -- Hyperpolarized molecules in solution / Jan Henrik Ardenkjaer-Larsen .. [et al.] -- MR oximetry / Jeff F. Dunn -- MRI using intermolecular multiple-quantum coherences / Rosa Tamara Branca -- Experimental stroke research : the contributions of in vivo MRI / Therése Kallur and Mathias Hoehn -- Volumetry and other quantitative measurements to assess the rodent brain / Alize Scheenstra, Jouke Dijkstra, and Louise van der Weerd -- Models of neurodegenerative disease -- Alzheimer's anatomical and amyloid plaque imaging / Alexandra Petiet, Benoit Delatour, and Marc Dhenain -- MRI in animal models of psychiatric disorders / Dana S. Poole, Melly S. Oitzl, and Louise van der Weerd -- Spectroscopic imaging of the mouse brain / Dennis W.J. Klomp and W. Klaas Jan Renema -- Spinal cord -- MR of rodent models / Virginie Callot, Guillaume Duhamel, and Frank Kober -- Assessment of global cardiac function / Jürgen E. Schneider -- Plaque imaging in murine models of cardiovascular disease / Gert Klug, Volker Herold, and Karl-Heinz Hiller -- Interventional MRI in the cardiovascular system / Harald H. Quick -- MR for the investigation of murine vasculature / Christoph Jacoby and Ulrich Flögel -- MRI of the lung : non-invasive protocols and applications to small animal models of lung disease / Magdalena Zurek and Yannick Crémillieux -- Characterization of tumor vasculature in mouse brain by USPIO contrast-enhanced MRI / Giulio Gambarota and William Leenders -- Cancer models-multiparametric applications of clinical MRI in rodent hepatic tumor model / Feng Chen, Frederik De Keyzer, and Yicheng Ni -- BOLD MRI applied to a murine model of peripheral artery disease / Joan M. Greve -- Manganese-enhanced magnetic resonance imaging / Susann Boretius and Jens Frahm -- Spin echo BOLD fMRI on songbirds / Colline Poirier and Anne-Marie Van der Linden -- MRI to study embryonic development / Bianca Hogers -- Mouse phenotyping with MRI / X. Josette Chen and Brian J. Nieman -- Analysis of freshly fixed and museum invertebrate specimens using high-resolution, high-throughput MRI / Alexander Ziegler and Susanne Mueller -- Applications of hyperpolarized agents in solutions / Jan Henrik Ardenkjaer-Larsen [and others] -- Target-specific paramagnetic and superparamagnetic micelles for molecular MR imaging / Roel Straathof, Gustav J. Strijkers, and Klaas Nicolay -- Tracking transplanted cells by MRI- methods and protocols / Michel Modo -- MRI of CEST-based reporter gene / Guanshu Liu and Assaf A. Gilad.
  • 2009From: CRCnetBASE
    edited by Ron D. Frostig.
    Optical imaging of brain activity in vivo using genetically encoded probes / Matt Wachowiak and Thomas Knöpfel -- Two-photon functional imaging of neuronal activity / Fritjof Helmchen -- In vivo two-photon laser scanning microscopy with concurrent plasma-mediated ablation : principles and hardware realization / Philbert S. Tsai and David Kleinfeld -- MPScope 2.0 : a computer system for two-photon laser scanning microscopy with concurrent plasma-mediated ablation and electrophysiology / Quoc-Thang Nguyen ... [et al.] -- In vivo observations of rapid scattered light changes associated with neurophysiological activity / David M. Rector ... [et al.] -- Imaging the brain in action : real-time voltage-sensitive dye imaging of sensorimotor cortex of awake-behaving mice / Isabelle Ferezou, Ferenc Matyas, and Carl C.H. Petersen -- Flavoprotein fluorescence imaging of experience-dependent cortical plasticity in rodents / Katsuei Shibuki ... [et al.] -- Functional imaging with mitochondrial flavoprotein autofluorescence : theory, practice, and applications / T. Robert Husson and Naoum P. Issa -- Visualizing adult cortical plasticity using intrinsic signal optical imaging / Ron D. Frostig and Cynthia H. Chen-Bee -- Fourier approach for functional imaging / Valery A. Kalatsky -- Optical imaging of neuronal activity in the cerebellar cortex using neutral red / Timothy J. Ebner, Gang Chen, and Wangcai Gao -- Quantitative in vivo imaging of tissue absorption, scattering, and hemoglobin concentration in rat cortex using spatially modulated structured light / David J. Cuccia ... [et al.] -- Intraoperative optical imaging / K.C. Brennan and Arthur W. Toga -- Noninvasive imaging of cerebral activation with diffuse optical tomography / Theodore J. Huppert, Maria Angela Franceschini, and David A. Boas -- Fast optical signals : principles, methods, and experimental results / Gabriele Gratton and Monica Fabiani.
  • 2012From: Springer
    Jean-Marie Saudubray, Georges van den Berghe, John H. Walter (editors).
    I. Diagnosis and Treatment: General Principles -- 1. Clinical Approach to Inborn Errors of Metabolism in Pediatrics / Jean-Marie Saudubray -- 2. Inborn Errors of Metabolism in Adults: A Diagnostic Approach to Neurological and Psychiatric Presentations / Frédéric Sedel -- 3. Newborn Screening for Inborn Errors of Metabolism / Bridget Wilcken, Piero Rinaldo, Dietrich Matern -- 4. Diagnostic Procedures: Functional Tests and Post-mortem Protocol / Guy Touati, Fanny Mochel, Daniel Rabier -- 5. Emergency Treatments / Carlo Dionisi-Vici, Hélène Ogier de Baulny -- II. Disorders of Carbohydrate Metabolism -- 6. The Glycogen Storage Diseases and Related Disorders / Pascal Laforêt, David A. Weinstein, G. Peter, A. Smit -- 7. Disorders of Galactose Metabolism / Gerard T. Berry, John H. Walter -- 8. Disorders of the Pentose Phosphate Pathway / Mirjam M.C. Wamelink, Vassili Valayannopoulos, Cornelis Jakobs -- 9. Disorders of Fructose Metabolism / Beat Steinmann, René Santer -- 10. Persistent Hyperinsulinaemic Hypoglycaemia / Pascale de Lonlay, Jean-Marie Saudubray -- 11. Disorders of Glucose Transport / René Santer, Jörg Klepper -- III. Disorders of Mitochondrial Energy Metabolism -- 12. Disorders of Pyruvate Metabolism and the Tricarboxylic Acid Cycle / Linda J. De Meirleir, Michèle Brivet, Angeles Garcia-Cazorla -- 13. Disorders of Mitochondrial Fatty Acid Oxidation and Related Metabolic Pathways / Andrew A.M. Morris, Ute Spiekerkoetter -- 14. Disorders of Ketogenesis and Ketolysis / Andrew A.M. Morris -- 15. Defects of the Respiratory Chain / Arnold Munnich, Agnès Rötig, Marlène Rio -- 16. Creatine Deficiency Syndromes / Sylvia Stöckler-Ipsiroglu, Saadet Mercimek- Mahmutoglu, Gajja S. Salomons -- IV. Disorders of Amino Acid Metabolism and Transport -- 17. Hyperphenylalaninaemia / John H. Walter, Robin H. Lachmann, Peter Burgard -- 18. 18 Disorders of Tyrosine Metabolism / Anupam Chakrapani, Paul Gissen, Patrick McKiernan -- 19. Branched-chain Organic Acidurias/Acidaemias / Hélène Ogier de Baulny, Carlo Dionisi-Vici, Udo Wendel -- 20. Disorders of the Urea Cycle and Related Enzymes / Frits A. Wijburg, Marie-Cécile Nassogne -- 21. Disorders of Sulfur Amino Acid Metabolism / Generoso Andria, Brian Fowler, Gianfranco Sebastio -- 22. Disorders of Ornithine Metabolism / Matthias R. Baumgartner, David Valle -- 23. Cerebral Organic Acid Disorders and Other Disorders of Lysine Catabolism / Georg F. Hoffmann, Stefan Kölker -- 24. Nonketotic Hyperglycinaemia (Glycine Encephalopathy) / Olivier Dulac, Marie-Odile Rolland --25. Disorders of Proline and Serine Metabolism / Jaak Jaeken -- 26. Transport Defects of Amino Acids at the Cell Membrane: Cystinuria, Lysinuric Protein Intolerance and Hartnup Disorder / Kirsti Näntö-Salonen, Harri Niinikoski, Olli G. Simell -- V. Vitamin-Responsive Disorders -- 27. Biotin-responsive Disorders / Matthias R. Baumgartner, Terttu Suormala -- 28. Disorders of Cobalamin and Folate Transport and Metabolism / David Watkins, David S. Rosenblatt, Brian Fowler -- VI. Neurotransmitter and Small Peptide Disorders -- 29. Disorders of Neurotransmission / Àngels García-Cazorla, K. Michael Gibson, Peter T. Clayton -- 30. Disorders in the Metabolism of Glutathione and Imidazole Dipeptides / Ertan Mayatepek, Jaak Jaeken -- 31. Trimethylaminuria and Dimethylglycine Dehydrogenase Deficiency / Valerie Walker, Ron A. Wevers -- VII. Disorders of Lipid and Bile Acid Metabolism -- 32. Dyslipidaemias / Annabelle Rodriguez-Oquendo, Peter O. Kwiterovich, Jr. -- 33. Disorders of Cholesterol Synthesis / Hans R. Waterham, Peter T. Clayton -- 34. Disorders of Bile Acid Synthesis / Peter T. Clayton -- 35. Disorders of Phospholipid and Glycosphingolipid Synthesis / Foudil Lamari, Fréderic Sédel, Jean-Marie Saudubray -- VIII. Disorders of Nucleic Acid and Heme Metabolism -- 36. Disorders of Purine and Pyrimidine Metabolism / Georges van den Berghe, M.-Françoise Vincent, Sandrine Marie -- 37. Disorders of Haem Biosynthesis / Charles Marquez Lourenço, Chul Lee, Karl E. Anderson -- IX. Disorders of Metal Transport -- 38. Disorders in the Transport of Copper, Iron, Magnesium, Manganese, Selenium and Zinc / Marc Bierings, Peter Clayton, Roderick H.J. Houwen -- X. Organelle-Related Disorders: Lysosomes, Peroxisomes, and Golgi and Pre-Golgi Systems -- 39. Disorders of Sphingolipid Metabolism and Neuronal Ceroid-Lipofuscinoses / Marie T. Vanier, Catherine Caillaud -- 40. Mucopolysaccharidoses and Oligosaccharidoses / J. Ed Wraith -- 41. Peroxisomal Disorders / Bwee Tien Poll-The, Patrick Aubourg, Ronald J.A. Wanders -- 42. Congenital Disorders of Glycosylation / Jaak Jaeken -- 43. Cystinosis / Michel Broyer, Patrick Niaudet -- Appendix A. Medications Used in the Treatment of Inborn Errors / JH Walter and JE Wraith.
  • 2016From: Springer
    Jean-Marie Saudubray, Matthias R. Baumgartner, John Walter (eds.).
    Section I Diagnosis and Treatment: General Principles -- Section II Disorders of Carbohydrate Metabolism -- Section III Disorders of Mitochondrial Energy Metabolism -- Section IV Disorders of Amino Acid Metabolism and Transport -- Section V Vitamin-Responsive Disorders -- Section VI Neurotransmitter and Small Peptide Disorders -- Section VII Disorders of Lipid and Bile Acid Metabolism -- Section VIII Disorders of Nucleic and Heme Metabolism -- 35 Disorders of Purine and Pyrimidine Metabolism -- 36 Disorders of Haem Biosynthesis -- Section IX Disorders of Metal Transport -- Section X Organelle-Related Disorders: Lysosomes, Peroxisomes, and Golgi and Pre-Golgi Systems -- Section XI Appendices.
  • compiled and edited by Phillip L. Altman and Dorothy Dittmer Katz.
    PrintStatus: Not Checked OutLane Catalog Record
    v. 1. Mouse and rat -- v. 2. Hamster, guinea pig, rabbit, and chicken.
  • Anicham P. Kumarasamy.
    This dissertation is composed of three essays that analyze incentive problems concerning the health care of end stage renal disease (ESRD) in the United States. The first essay is concerned with the unintended consequences of a proposed change to the system for allocating kidneys to patients on the transplant waiting list. In particular, policymakers in the United States have recently proposed to modify the kidney allocation system by assigning higher priority to patients who are on dialysis longer. The essay examines how this change may create an incentive for physicians to start their patients on dialysis prematurely and investigates how to mitigate this unintended behavior. The second essay investigates physician behavior directly from data, analyzing why the kidney function at which patients start dialysis has been rising over time in the United States. That is, why do patients seem to be starting dialysis earlier and earlier over time? The third essay is concerned with the quality of care of profit-maximizing dialysis providers. In particular, Medicare recently restructured its reimbursement system and publicly released previously confidential data on the quality of care of dialysis facilities. The essay analyzes how such policy changes influence the quality of care decisions of profit-maximizing dialysis providers. On the whole, this dissertation is intended to help policymakers as they make difficult decisions about kidney allocation policies, ESRD-related spending, dialysis reimbursement, and disclosing dialysis facility performance information.
  • Gregory Russell Samanez Larkin.
    As the proportion of older adults continues to grow rapidly here in the U.S. and across the globe, aging adults may be required to make increasingly more independent health-related and financial decisions. Thus, it is increasingly imperative to better understand the impact of age-related psychological changes on decision making. Although a growing body of research has linked age-related deficits in attention, memory, and cognitive control to changes in medial temporal and lateral prefrontal cortical function, remarkably little research has investigated the influence of aging on valuation and associated mesolimbic function in the striatum and medial prefrontal cortex. Likewise, theoretical accounts link age-related declines in a number of basic cognitive abilities to dopamine function, but research has largely neglected age differences in value-based learning and decision making which also rely on the dopamine system. Recent findings reveal age-related declines in the structure of striatal and medial frontal circuits, however it was not previously clear whether these structural declines contribute to functional deficits in incentive processing. Thus, the seven experiments presented here explored potential age differences across a range of value-based tasks from basic anticipatory and consummatory responses to reward cues (Experiments 1--2) to probabilistic value-based learning (Experiments 2--5) to investment decision making (Experiments 6--7). The studies focus on both age-related and non-age-related individual differences in learning and decision making across the adult life span. Overall, three sets of key findings emerge. The first set of experiments on anticipatory affect reveal evidence for an age-related asymmetry in the anticipation of monetary gains and losses, such that older adults appear less sensitive to the prospect of financial loss than younger adults. In a subset of adults, this anticipatory affective bias contributes to loss avoidance learning impairments through the sensitivity of the anterior insula. Thus, although a relative lack of anxiety about potential loss may contribute to increased well-being, this asymmetry may put individuals with blunted loss anticipation at risk for certain types of financial mistakes. In fact, we show that individuals who perform poorly on the laboratory-based loss avoidance learning task accrue more financial debt in the real world. The second set of experiments focus on age differences in value-based learning and reveal that although older adults show intact neural representation of the actual value of reward outcomes, there is an age-related decline in the neural representation of prediction error at outcome in the striatum and medial prefrontal cortex. Age differences in learning are magnified when choice set size is increased, but when the number of trials is extended older adults reach the same performance criterion as younger adults. The third set of experiments focus on age differences in risky financial decision making and reveal that older adults make more suboptimal choices than younger adults when choosing risky assets. Neuroimaging analyses reveal that the representation of expected value in the nucleus accumbens and medial prefrontal cortex is correlated with optimal investment decisions, and that the age-related increase in risky investment mistakes is mediated by a novel neural measure of variability in nucleus accumbens activity. The presentation of value information through visual decision aids improves investment choices in both younger and older adults. These findings are consistent with the notion that mesolimbic circuits play a critical role in optimal choice, and imply that providing simplified information about expected value may improve financial risk taking across the adult life span. Across the experiments, the findings suggest that both age-related affective biases and probabilistic learning impairments can influence decision making both in the laboratory and in the real world through insular and mesolimbic brain regions. Importantly, age-related impairments are reduced under supportive task conditions (designed to target the brain systems identified using neuroimaging). Together, the set of experiments presented here suggests that understanding how the brain processes value information may eventually inform the design of more targeted and effective behavioral interventions for investors of all ages.
  • 2008From: ProQuest Ebook Central
    edited by Frank A. Sloan and Hirschel Kasper.
    To find an answer, one must know the question : health economics and public policy / Henry J. Aaron -- Health capital : theory and empirical evidence / Donna Gilleskie -- What we know and don't know about the effects of cost sharing on the demand for medical care - and so what? / Joseph P. newhouse and Anna D. Sinaiko -- Adverse selection and moral hazard : implications for health insurance markets / Mark V. Pauly -- Direct-to-consumer advertising in health care : an overview of economic issues / Ernst R. Berndt and Julie M. Donohue -- Reefer Madness, Frank the Tank, or Pretty Woman : to what extent do addictive behaviors respond to incentives? / John Cawley -- Medical career choices and rates of return / Sean Nicholson -- The effects of incentives on pharmaceutical innovation / Frank A. Sloan and Chee-Ruey Hsieh -- Physician fees and behavior : implications for structuring a fee schedule / Thomas G. McGuire -- Physician pay for performance : alternative perspectives / Brian R. Golden and Frank A. Sloan -- Competition, information provision, and hospital quality / Gautam Gowrisankaran -- Summing up / Frank A. Sloan and Hirschel Kasper.
  • 2008From: Springer
    [edited by] Feliciano Crovella, Giovanni Bartone, Landino Fei.
  • 2006From: Springer
    volume editor, Jessup M. Shively.
  • Dariya S. Glazer.
    Structural Genomics consortia aim to determine the structure of proteins with novel folds. In order to interpret their biological significance, it is critical to annotate the functions of these structures. Most structures are solved by X-ray crystallography experiments and represent static snapshots of the molecules. Structure-based function prediction methods do not perform well when the snapshots fail to display the relevant functional conformations. We show that coupling structure-based function prediction methods to molecular dynamics simulations considerably improves their performance in locating calcium binding sites. Our approach can be easily extended to other functions of interest. In particular, we generated short- to medium- scale molecular simulation trajectories (1ns -- 10ns) using GROMACS, a software suite developed for creating molecular dynamics simulations. Gromos 43a5, Gromos 53a6, AMBER '96, AMBER '99SB, AMBER '03, and OPLS-AA force fields were used to generate trajectories for 11 pairs of PDB structures, HOLO and APO form for the presence of calcium ions in the structures (22 structrures in total). Extracting structures at various time points over the course of the simulations we created structural ensembles which inform about the dynamic nature of each of the simulation systems. Using FEATURE, a machine learning algorithm that evaluates the presence of enriched physico-chemical properties around a site of interest, we analyzed the structural ensembles for the presence of calcium binding sites. We devised a clustering algorithm which allowed for definitive determination of the similarity of the local environments around the points identified by FEATURE as potential calcium binding site centers in different structural ensembles for each of the 22 PDB structures. Our results indicate that short scale simulations with 2 or 3 different force fields generate sufficient structural diversity to allow for improved identification of calcium binding sites. Furthermore, inclusion of calcium ions in the simulation systems does not significantly improve the performance of FEATURE. This result highlights the need for improved force fields, such that the dynamic nature of calcium binding sites can be accurately reproduced.
  • 2010From: WHO
    "Half the world's people currently live in rural and remote areas. The problem is that most health workers live and work in cities. This imbalance is common to almost all countries and poses a major challenge to the nationwide provision of health services. Its impact, however, is most severe in low income countries. ... The World Health Organization (WHO) has therefore drawn up a comprehensive set of strategies to help countries encourage health workers to live and work in remote and rural areas. These include refining the ways students are selected and educated, as well as creating better working and living conditions. ... The guidelines ... complement the WHO Global Code of Practice on the International Recruitment of Health Personnel, adopted by the Sixty-third World Health Assembly in May 2010. The Code offers a framework to manage international migration over the medium to longer term. The guidelines are a tool that can be used straight away to address one of the first triggers to internal and international migration - dissatisfaction with living and working conditions in rural areas. Together, the code of practice and these new guidelines provide countries with instruments to improve workforce distribution and enhance health services." - p. i
    Also available: Print – 2010
  • 2014From: Springer
    Alexandre Trifilieff, editor.
    Chronic obstructive pulmonary disease (COPD) is a multi-component condition that results in increasingly limited airflow, usually associated with an abnormal inflammatory response of the lung. It constitutes a major public health burden worldwide, while only very few effective therapies are available. This book provides a comprehensive overview of the development of Onbrez Breezhaler, a newly approved once-daily inhaled 2 agonist for the treatment of COPD. It reviews the current pharmacotherapy for COPD and discusses topics such as the chemical design and the pre-clinical pharmacology of the molecule, the early clinical development, the INHANCE study (which provides a successful example of the use of an adaptive design in the confirmatory setting) and the Phase III clinical efficacy study, as well as the history and performance of the Breezhaler device. Finally, a list of emerging targets is included that could well offer future treatment options for COPD.
  • Executive Office of the President, President's Council of Advisors on Science and Technology.
  • pub. sous la direction du secrétaire général.
    PrintStatus: Not Checked OutLane Catalog Record
  • Isaac D. Welt.
    PrintStatus: Not Checked OutLane Catalog Record
    v. 1 (1931-1950) -- v. 2., pt. 1-2. (1951-1955) -- v. 3. (1956-1959).
  • 1971-From: TruvenSearch Index nominum via the main Micromedex search screen.
    Also available: Print – <2011>
  • 2007From: Springer
    C.P. Khare (ed.).
  • 2007From: CRCnetBASE
    edited by Tad S. Murty, U. Aswathanarayana, N. Nirupama.
    Prologue / Barbara H. Keating -- Pt. 1. Geostructural environment of tsunami genesis -- A historical account of the earthquakes and tsunamis in the Indian Ocean / B. K. Rastogi -- Impact of coastal morphology, structure and seismicity on the tsunami surge / K.S.R. Murthy ... [et al.] -- Tsunamigenic sources in the Indian Ocean: factors and impact on the Indian landmass / R.K. Chadha -- Paleo-tsunami and storm surge deposits / K. Arun Kumar, H. Achyuthan, and N. Shankar -- Overview and integration of part 1 / U. Aswathanarayana -- Pt. 2. Modelling of tsunami generation and propagation -- A review of classical concepts on phase and amplitude dispersion: application to tsunamis / N. Nirupama ... [et al.] -- A partial explanation for the initial withdrawal of the ocean during a tsunami / N. Nirupama ... [et al.] -- The energetics of the tsunami of 26 December 2004 in the Indian Ocean: a brief review / N. Nirupama ... [et al.] -- Possible amplification of the tsunami through coupling with internal waves / N. Nirupama ... [et al.] -- Numerical modeling of the Indian Ocean tsunami / Z. Kowalik ... [et al.] -- Modelling techniques for understanding the Indian Ocean tsunami propagation / V. P. Dimri and K. Srivastava -- Validation of tsunami beach run-up height predictive model based on work-energy theorem / G. Muraleedharan ... [et al.] -- Normal modes and tsunami coastal effects / N. Nirupama ... [et al.] -- Helmholtz mode and K-S-P waves: application to tsunamis / N. Nirupama ... [et al.] -- Numerical models for the Indian Ocean tsunami of 26 December 2004: a brief review / P. Chittibabu and T.S. Murty -- The Cauchy-Poisson problem: application to tsunami generation and propagation / N. Nirupama ... [et al.] -- A review and listings of tsunami heights and travel times for the 26 December 2004 event / I. Nistor ... [et al.] -- Overview and integration of part 2 / N. Nirupama -- Pt. 3. Tsunami detection and monitoring systems -- Satellite detection of pre-earthquakes thermal anomaly and sea water turbidity associated with the great Sumatra earthquake / A. K. Saraf ... [et al.] -- Possible detection in the ionosphere of the signals from earthquake and tsunamis / T. S. Murty ... [et al.] -- Seismo-electromagnetic precursors registered by DEMETER satellite / A.K. Gwal ... [et al.] -- Web-enabled and real-time reporting: cellular based instrumentation for coastal sea level and surge monitoring / A. Joseph and R. G. Prabhudesai -- Methodologies for tsunami detection / T.S. Murty ... [et al.] -- Tsunami travel time atlas for the Indian Ocean / P.K. Bhaskaran ... [et al.] -- Overview and integration of part 3 / N. Nirupama -- Pt. 4. Biophysical and socio-economic dimensions of tsunami damage -- Performance of structures affected by the 2004 Sumatra tsunami in Thailand and Indonesia / M. Saatcioglu, A. Ghobarah, and I. Nistor -- Field observations on the tsunami impact along the Kerala Coast, Southwest India / N.P. Kurian, T.N. Prakash, and M. Baba -- Ecological impact on the Indian Ocean tsunami / C.S.P. Iyer -- Tsunami damage to the south eastern coast of India / N. Chandrasekar and R. Ramesh -- Hydrophysical manifestations on the Indian Ocean tsunami / Y. Sadhuram, T.V. Ramana Murthy, and B.P. Rao -- Tsunamis and marine life / D.V. Subba Rao ... [et al.] -- Tsunami impact on coastal habitats of India / P.N. Sridhar ... [et al.] -- Overview and integration of part 4 / U. Aswathanarayana -- Pt. 5. Quo Vadis -- Protection measures against tsunami-type hazards for the coast of Tamil Nadu, India / V. Sundar -- Protective role of coastal ecosystems in the context of the tsunami in Tamil Nadu Coast, India: implications for hazard preparedness / A. Mascarenhas and S. Jayakumar -- Integrated preparedness systems / U. Aswathanarayana -- Social and political aspects of tsunami response, recovery, and preparedness planning: a transdisciplinary approach from Canada / C. Amaratunga and H. Smith Fowler -- An ideal conceptual tsunami warning system for the Indian Ocean / T.S. Murty ... [et al.] -- Overview and integration of part 5 / N. Nirupama.
  • Mukerji, Bishnupada.
    PrintStatus: Not Checked OutLane Catalog Record
    1. Indigenous drugs.
  • 2011From: Springer
    Anthony A. Bavry, Dharam J. Kumbhani.
    1 Vascular anatomy -- 2 Catheters, guidewires, sheaths, and balloons -- 3 Complex coronary interventions -- 4 Fractional flow reserve and intravascular ultrasound -- 5 Peripheral interventions -- 6 Structural heart disease.
  • 2006From: Springer
    edited by Asher Ben-Arieh and Robert M. George.
  • 1892-From: Google Books
    by Thomas Dutton ...
    Also available: Print – 1892.
  • 2013From: ScienceDirect
    Richard S. Hallam.
    Individual Case Formulation presents formulation as a process that can be taught systematically to trainee therapists. The book begins by discussing assorted theories of case formulation, and critiques their ability to be applied in real world situations. The individual case formulation approach is then defined and discussed as a way to integrate the best of what different theoretical orientations have to offer in conjunction with the expertise and clinical judgment of the therapist. The book proposes a systemic/functional framework that focuses on difficulties as defined by the client and emphasizes constructive solutions to problems rather than symptom reduction. Moving from theory to application, the book then guides therapists in how to conduct assessment interviews, how to reach a provisional formulation, how to test that formulation for accuracy and reformulate if necessary, how a therapist can make explicit what their clinical reasoning was in making the case formulation, and provides case examples and transcripts so readers will better grasp the concepts in action.
  • Emily Marguerite Drabant.
    PrintStatus: Not Checked OutLane Catalog Record
  • 2015From: Springer
    Tobias Fischer, Martin Langanke, Paul Marschall, Susanne Michl, editors.
    In 2009 the University Medicine Greifswald launched the "Greifswald Approach to Individualized Medicine" (GANI_MED) to implement biomarker-based individualized diagnostic and therapeutic strategies in clinical settings. Individualized Medicine (IM) has led not only to controversies about its potentials, but also about its societal, ethical and health economic implications. This anthology focusses on these areas and includes ? next to clinical examples illustrating how the integrated analysis of biomarkers leads to significant improvement of therapeutic outcomes for a subgroup of patients ? chapters about the definition, history and epistemology of IM. Additionally there is a focus on conceptual philosophical questions as well as challenges for applied research ethics (informed consent process, the IT-based consent management and the handling of incidental findings). Finally it pays attention to health economic aspects. The possibilities of IM to initiate a paradigm shift in the German health care provision are investigated. Furthermore, it is asked whether the G-DRG system is ready for the implementation of such approaches into clinical routine.
  • 2012From: Springer
    Sibel Yildirim.
  • 2012From: Springer
    by Vivi M. Heine, Stephanie Dooves, Dwayne Holmes, Judith Wagner.
  • 2011From: Springer
    Karl Reinhard Aigner, Frederick Oscar Stephens (editors).
  • 2016From: Springer
    Karl Reinhard Aigner, Frederick Oscar Stephens, editors.
    1. Introduction: overview, history, terminology and early clinical experience -- 2. The principle of dose response in antineoplastic drug delivery -- 3. Drug removal systems and induction chemotherapy -- 4. Cryotherapy -- 5. Local and regional hyperthermia -- 6. The role of hypoxia and hyperthermia in chemotherapy -- 7. Induction chemotherapy in head and neck cancers -- 8. Isolated thoracic perfusion with carotid artery infusion for advanced and chemoresistant tumors of the parotid gland and tonsils -- 9. Induction chemotherapy for breast cancer -- 10. Patients with locally advanced breast cancer receiving intra-arterial induction chemotherapy: report of a phase II clinical study -- 11. Regional chemotherapy for thoracic wall recurrence and metastasized breast cancer -- 12. Cytoreductive surgery and "hyperthermic intraperitoneal chemotherapy (HIPEC)" -- 13. Induction bidirectional chemotherapy for gastric cancer with peritoneal dissemination -- 14. Esophageal cancer -- 15. Gastric cancer -- 16. Systemic and regional chemotherapy for advanced and metastasized pancreatic cancer -- 17. Interventional radiological procedures for port-catheter implantation -- 18. Induction chemotherapy for hepatocellular carcinoma -- 19. Transarterial treatment of primary and secondary liver tumors -- 20. Pelvic perfusion for rectal cancer -- 21. Isolated pelvic perfusion with chemofiltration for pelvic malignancies: anal, cervical, and bladder cancer -- 22. Penile cancer treated by intra-arterial infusion -- 23. Systemic induction chemotherapy for advanced-stage epithelial ovarian cancer -- 24. Regional chemotherapy in recurrent platinum-refractory ovarian cancer -- 25. Isolated limb perfusion for melanoma -- 26. Isolated limb infusion -- 27. Induction treatment in sarcomas -- 28. Isolated limb perfusion for locally advanced soft tissue sarcoma -- 29. Induction chemotherapy in treatment of sarcomas -- 30. Isolation perfusion systems: lungs -- 31. Metastatic cancers in lung: isolated lung perfusionn: clinical studies -- 32. Isolated thoracic perfusion with chemofiltration (ITP-F) for advanced and pretreated non-small-cell lung cancer -- 33. Toxicity profiles with systemic versus regional chemotherapy.
  • contributors, J. Brozek ... [et al.].
    PrintStatus: Not Checked OutLane Catalog Record
  • [G.D. Clayton ... et al].
    PrintStatus: Not Checked OutLane Catalog Record
    v. 1. General principles -- v. 2. Toxicology.
  • 2008From: CRCnetBASE
    editor, William M. Reichert.
    Overview of wound healing in different tissue types / John D. Stroncek and William M. Reichert -- Considerations for chronically implanted electrodes for brain interfacing / Warren M. Grill -- Thermal considerations for the design of an implanted cortical brain-machine-interface / Patrick D. Wolf -- In vitro models for neuroelectrodes: a paradigm for studying tissue-materials interactions in the brain / Vadim Polikov ... [et al.] -- In vivo solute diffusivity in brain tissue surrounding indwelling neural implants -- Michael J. Bridge and Patrick A. Tresco -- A molecular perspective on understanding and modulating the performance of chronic CNS recording electrodes / Wei He and Ravi V. Bellamkonda -- Soft, fuzzy, and bioactive conducting polymers for improving the chronic performance of neural prosthetic devices / Dong-Hwan Kim ... [et al.] -- Strategies for regeneration and repair in the injured CNS / Molly S. Shoichet ... [et al.].
  • 2008From: Springer
    Annette Baudisch.
  • Emily K. Abel.
    PrintStatus: Not Checked OutLane Catalog Record
    The good death at home -- Medical professionals (sometimes) steps in -- Cultivating detachment, sidetracking care -- Institutionalizing the incurable -- "All our dread and apprehension" -- "Nothing more to do" -- A place to die -- The sacred and the spiritual.
  • 2011From: Springer
    Pranee Liamputtong, editor.
    Infant feeding beliefs and practices across cultures: an introduction -- Managing the lactating body: the breastfeeding project in the age of anxiety -- Attitudes to breastfeeding -- The imperative to breastfeed: an Australian perspective -- Infant feeding and the problems of policy -- Shifting identities: social and cultural factors that shape decision-making around sustaining breastfeeding -- Breastfeeding under the blanket: exploring the tensions between health and social attitudes to breastfeeding in the United States, Ireland, and the United Kingdom -- Breastfeeding beliefs and practices among employed women: a Thai cultural perspective -- Good mothers and infant feeding practices among women in Northern Thailand -- Breastfeeding in sub-Saharan Africa: still the best despite the risk of HIV -- Infant feeding in the era of HIV: challenges and opportunities -- Facing competing cultures of breastfeeding: the experience of HIV-positive women in Burkina Faso -- Fluid boundaries: multiple meanings of the illness 'moto' in Northern Malawi -- From traditional to optimal breastfeeding practices: selected cases from Central and Southern Africa -- Hoki kit e ukaipo: reinstating Maori infant care practices to increase breastfeeding rates -- Infant feeding in indigenous Australian communities -- Breastfeeding, vertical disease transmission and the volition of medicines in Malawi -- Infant feeding beliefs and practices in Islamic societies: focusing on rural Turkey -- Early initiation of breastfeeding and its beneficial effects in Japan -- Socio-cultural factors influencing feeding patterns within 6 months postpartum in rural Vietnam -- Infant feeding following migration: attitudes and practices of women born in Turkey and Vietnam after migration to Australia.
  • [L.M. Pastore and M.F. MacDorman.
    Also available: Print – 1995
  • 2016From: Springer
    Nora V. Laver, Charles S. Specht, editors.
    1. Epidemiology and Clinical Significance of Ocular Infection / Charles S. Specht and Nora V. Laver -- 2. Pathogenic Properties of Infectious Organisms and Tissue Reactions / Nora V. Laver and Charles S. Specht -- 3. Ocular Infection Worldwide / Mary Klassen-Fischer and Ronald C. Neafie -- 4. Conjunctivitis / Tayyeba K. Ali and Seth M. Pantanelli -- 5. Corneal Infection and Ulceration / Seth M. Pantanelli and Tayyeba K. Ali -- 6. Intraocular Infection / Andre J. Witkin -- 7. Infections of the Eyelids, Orbit, and Ocular Adnexa / Guneet Sodhi, Erica Liu, Jennifer Renz, Katrinka Heher, and Mitesh Kapadia -- 8. Ocular Infection in Children / Mitchell B. Strominger -- 9. Anti-infective Therapy for Ocular Infection / Jihye Kim -- 10. Role of the Clinical Microbiology Laboratory / David W. Craft and Wallace H. Greene.
  • 2009From: Springer
    Heino Kienapfel, Klaus-Dieter Kühn, (eds.).
  • 2012From: Springer
    Rihard Trebše, editor.
    Part 1 -- Introduction / Rihard Trebše -- Joint Replacement: Historical Overview / Rihard Trebše, Anže Mihelič -- Biomaterials in Artificial Joint Replacements / Rihard Trebše -- The Definition of Prosthetic Joint Infections (PJI) / Rihard Trebše, Andrej Trampuž -- Classification of Prosthetic Joint Infections / Rihard Trebše, Anže Mihelič -- The Epidemiology of Total Joint Arthroplasty Infections / David J. Jaekel, Kevin L. Ong, Edmund C. Lau -- Septic Complications in Arthroplasty / Gerold Labek -- Perioperative Antibiotic Prophylaxis in Total Joint Arthroplasty / Nataša Faganeli -- Risk Factors for Prosthetic Joint Infections / René Mihalič, Matevž Topolovec -- Pathogenesis of Prosthetic Joint Infections / Rihard Trebše, Jurij Štalc -- Bacteria-Biomaterial Interactions / Antti Soininen, Emilia Kaivosoja, Jaime Esteban -- Biomaterial-Host Interactions in Aseptic and Septic Conditions / Jukka Pajarinen, Yuya Takakubo, Zygmunt Mackiewicz -- Influence of Wear Particles on Local and Systemic Immune System / Emmanuel Gibon, Stuart B. Goodman -- Diagnostic Evaluations / Rihard Trebše -- Synovial Fluid Cytology / René Mihalič, Dunja Terčič -- Histological Analysis of Periprosthetic Tissue for Detecting Prosthetic Joint Infection / Andrej Cör -- Microbiological Diagnosis of Prosthetic Joint Infection / Jaime Esteban, Concepción Pérez-Jorge, Ramón Pérez-Tanoira -- Microbiological Processing of Samples in the Investigation of Suspected Prosthetic Joint Infection / David G. Partridge, Rob Towsend -- Part 2 -- Molecular Diagnosis of Prosthetic Joint Infection / Jaime Esteban, Diana Molina-Manso, Gema del-Prado -- Current Treatment Strategies in Prosthetic Joint Infections / Rihard Trebše Total Ankle Replacement Infections / Michaela Maria Schneiderbauer -- Periprosthetic Infection Issues with Osseointegrated (OI) Implant Technology in Amputees / Catherine Loc-Carrillo, Alec C. Runyon, James Peter Beck -- The Algorithm for Diagnostic Evaluation and Treatment / Rihard Trebše, Andrej Trampuž -- Bone Grafts and Bone Graft Substitutes in Infected Arthroplasty / Martin Clauss, Thomas Ilchmann.
  • 2015From: ClinicalKey
    edited by Yehuda Shoenfeld, Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel Hashomer, affiliated with Sackler Faculty of Medicine, Tel Aviv University, and Laura Schwarz-Kip Chair for Research of Autoimmune Diseases, Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv, Israel, Nancy Agmon-Levin, Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel Hashomer, affiliated with Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv, Israel, Noel R. Rose, Department of Pathology, Department of Molecular Microbiology and Immunology, the Center for Autoimmune Disease Research, the Johns Hopkins Schools of Medicine and Public Health, Baltimore, Maryland, USA.
  • John H.L. Playfair, Gregory J. Bancroft.
    PrintStatus: Not Checked OutLane Catalog Record
  • 2006From: Karger
    volume editors, Thomas Dittmar, Kurt S. Zaenker, Axel Schmidt.
    In remembrance of Rudolf Virchow (1821-1902) / Schmidt, A. -- In memoriam of Rudolf Virchow: a historical retrospective including aspects of inflammation, infection and neoplasia / Schmidt, A., Weber, O.F. -- Aneuploidy and cancer: from correlation to causation / Duesberg, P. ... [et al.] -- Adult stem cell theory of the multi-stage, multi-mechanism theory of carcinogenesis: role of inflammation on the promotion of initiated stem cells / Trosko, J.E., Tai, M.-H. -- Helicobacter pylori and gastric neoplasia / Leung, W.K. -- Schistosomiasis and neoplasia / Yosry, A. -- Relevant oncogenic viruses in veterinary medicine: original pathogens and animal models for human disease / Truyen, U., L"chelt, M. -- The inflammatory tumor microenvironment and its impact on cancer development / de Visser, K.E., Coussens, L.M. -- Co-opting macrophage traits in cancer progression: a consequence of tumor cell fusion? / Pawelek, J. ... [et al.] -- Carcinogenesis driven by bone marrow-derived stem cells / Dittmar, T. ... [et al.] -- Chemokine-directed metastasis / Gomperts, B.N., Strieter, R.M. -- Involvement of chemokine receptors in organ-specific metastasis / Zlotnik, A. -- Visualization of tumor cell extravasation / Heyder, C. ... [et al.] -- Options for visualizing metastatic disease in the living body / Helms, M.W., Brandt, B.H., Contag, C. -- Infection, inflammation and neoplasia: an interdisciplinary challenge / Zaenker, K.S.
    Also available: Print – 2006
  • 2007From: Springer
    E. Meani...[et al.] (eds.) ; editorial coordinator: G. Calonego.
  • 2012From: Springer
    [edited by] H.K.F. van Saene, Luciano Silvestri, Miguel Angel De La Cal ; foreword by Julian Bion.
    pt. I. Essentials in clinical microbiology -- pt. II. Antimicrobials -- pt. III. Infection control -- pt. IV. Infections on ICU -- pt. V. Special topics.
  • 2012From: Springer
    Joan Stein-Streilein, editor.
    The Eye as a model for immune privilege -- Immune privilege of the testis: meaning, mechanisms, and manifestations -- The Role of intrauterine immune privilege in perinatal infectious diseases -- The Liver as an immune-privileged site -- Immune homeostasis of the lung: the role of regulatory NKT cells in asthma -- Immune homeostasis of the gut.
  • 2015From: Springer
    Georg Maschmeyer, Kenneth V.I. Rolston, editors.
  • 2013From: Springer
    Hilary Humphreys, Bob Winter, Mical Paul.
    Infections in critically ill patients are more common than in most other parts of the hospital, and are often the most complicated to manage. Underlying disease and the reasons for admission make the diagnosis, management and prevention of infection challenging. Developments in technology, the treatment of previously untreatable malignancies, complex surgery procedures, and an increasing age profile result in more patients vulnerable to infection and a greater number of patients needing critical care support. Infections in the Adult Intensive Care Unit is designed to help trainee and practicising physician, surgeon or other medical professional manage the acutely ill patient in the critical care unit, before transfer from the emergency department, or on the hospital ward where effective management may avoid admission to the critical care unit. It has been co-authored by a clinical microbiologist, intensivist and clinical infectious diseases physician to cover some of the major infections presenting in the adult critical care unit. It provides broad principles to be used based on the latest evidence combined with common sense and the results of many years of combined experience.
  • 2016From: Oxford Medicine Online
    edited by Pranatharthi H. Chandrasekar.
    Infections in cancer patients / editor, Alison G. Freifeld -- Infections in solid organ transplant recipients / editors, Ajit P. Limaye and Lynne Strasfeld -- Infections in hematopoietic stem cell transplant (HSCT) recipients / editor, John R. Wingard -- Infections in patients receiving immunosuppressive drugs / editor, Emily A. Blumberg -- Infections in patients with immunosuppression due to miscellaneous conditions / editors, George J. Alangaden, Prantharthi H. Chandrasekar.
  • 2009From: Am Soc Microbiol
    edited by David Schlossberg.
    Contributors -- Preface -- Preface to the first edition -- 1: At the shore / Mark A Clemence and Richard L Guerrant -- 2: Freshwater: from lakes to hot tubs / Bertha S Ayi and David Dworzack -- 3: Camper's uninvited guests / Gordon E Schutze and Richard F Jacobs -- 4: Infections in the garden / Burke A Cunha and Diane H Johnson -- 5: With man's best friend / Julie M Collins and Bennett Lorber -- 6: Around cats / Ellie J C Goldstein and Craig E Greene -- 7: Feathered friends / Matthew E Levison -- 8: Less common house pets / Bruno B Chomel -- 9: With man's worst friend : the rat / James G Fox -- 10: Closed due to rabies / Jesse D Blanton and John W Krebs -- 11: Sports: the infectious hazards / Arezou Minooee, Leland S Rickman, and Geeta Gupta -- 12: Traveling abroad / Martin S Wolfe -- 13: From boudoir to bordello: sexually transmitted diseases and travel / Jonathan M Zenilman -- 14: Infections from body piercing and tattoos / Mukesh Patel and C Glenn Cobbs -- 15: Infectious diseases at high altitude / Buddha Basnyat, Thomas A Cumbo, and Robert Edelman -- 16: Infectious risks of air travel / Alexandra Mangili and Mark Gendreau -- 17: Perils of the petting zoo / John R Dunn and Frederick J Angulo -- 18: Infections on cruise ships / Vivek Kak -- 19: Exotic and trendy cuisine / Jeffrey K Griffiths -- Index.
  • 2016From: Am Soc Microbiol
    edited by David Schlossberg, Professor of Medicine, Temple University School of Medicine and Medical Director, Tuberculosis Control Program, Philadelphia Department of Public health, Philadelphia, PA.
    Preface -- Preface to the first edition -- Infections and intoxications from the ocean: risks of the shore / Mark A. Clemence and Richard L. Guerrant -- Infections acquired via fresh water: from lakes to hot tubs / Bertha Ayi -- Arthropod-borne diseases: the camper's uninvited guests / Gregory Juckett -- Infections acquired in the garden / Cheston B. Cunha and Burke A. Cunha -- Diseases transmitted by man's best friend: the dog / Jerry Jacob and Bennett Lorber -- Diseases transmitted by cats / Ellie J.C. Goldstein and Fredrick M. Abrahamian -- Diseases transmitted by birds / Matthew E. Levison -- Diseases transmitted by less common house pets / Bruno B. Chomel -- Diseases transmitted by man's worst friend: the rat / James G. Fox -- Diseases transmitted by domestic livestock: perils of the petting zoo / John R. Dunn, Casey Barton Behravesh, and Frederick J. Angulo -- The ancient curse: rabies / Jesse D. Blanton and Ryan M. Wallace -- Sports: the infectious hazards / Geeta Gupta, Arezou Minooee, and Jeffrey Wang -- Infectious risks of traveling abroad / Lin H. Chen and Barbra M. Blair -- Sexually transmitted diseases and travel: from boudoir to bordello / Ann K. Avery and Jonathan M. Zenilman -- Infections from body piercing and tattoos / Mukesh Patel and C. Glenn Cobbs -- Infectious diseases at high altitude / Buddha Basnyat and Jennifer M. Starling -- Infectious risks of air travel / Alexandra Mangili, Tine Vindenes, and Mark Gendreau -- Infections on cruise ships / Vivek Kak -- Infections associated with exotic cuisine: the dangers of delicacies / Natasha Hochberg and Nahid Bhadelia.
  • 2014From: Ovid
    editors, W. Michael Scheld, Richard J. Whitley, Christina M. Marra.
    "This clinical reference on central nervous system infections is now in its thoroughly revised, updated Fourth edition. Over 70 leading experts provide comprehensive, current information on all infections--both neural-specific and systemic--that involve the central nervous system. Areas with significant new clinical information include treatment of tuberculosis, non-tubercular mycobacterial infections, brain abscess, and Lyme disease"--Provided by publisher.
  • 2013From: Springer
    Anton G. Kutikhin, Arseniy E. Yuzhalin, Elena B. Brusina.
    The Criteria of Inclusion of Infectious Agents in the List of Biological Carcinogens -- General Mechanisms of Biological Carcinogenesis -- The Role of Bacteria in Cancer Development -- The Role of Protozoa in Cancer Development -- The Role of Helminthes and Fungi in Cancer Development -- Organ Microbiota in Cancer Development: The Holy Grail of Biological Carcinogenesis -- Conclusions: Are We There Yet?
  • 2014From: Springer
    Valentina Stosor, Teresa R. Zembower, editors.
    While advances in both the treatment of cancer and the management of its complications have led to significant improvement in patient survival, infections remain a significant cause of morbidity and mortality in patients with neoplastic disease. In this patient population, infection risk results from a complex interplay between the host's underlying immunodeficiencies, local tumor effects, and treatment-induced immunosuppression. New chemotherapeutic approaches and antimicrobial prophylaxis and treatment practices continue to shape the spectrum of infections in these patients. Clinicians who treat infections in cancer patients are continually challenged by the emergence of new pathogens and by the increasing antimicrobial resistance of established ones. The aim of this book, is to emphasize unique aspects of management of infectious diseases in the cancer patient. With the increasing complexity of this patient population, optimal management requires a multidisciplinary approach, and this fact is fully reflected in the contributions, all from recognized authorities in the field. Ultimately, it is hoped that this volume will assist specialists in infectious diseases and haematology/oncology in the diagnosis, management, and prevention of infection and optimization of the overall care of patients with malignancies.
    Also available: Print – 2014
  • 2016From: Springer
    Paul Hofman, editor.
    Acquired Immunodeficiency Disease -- Actinomycosis -- Adenovirus -- Adiaspiromycosis -- Alveolar ecchinococcosis -- Amebiasis -- Ancylostomasis -- Angiostrongyliasis cantonesis infections -- Angiostrongylus costarecensis infections -- Anisakiasis -- Arthropods -- Artifacts -- Ascaridiasis -- Aspergillosis -- Bacillary angiomatosis -- Bacterial infections -- Balantidiasis -- Bartonellosis -- Bilharziasis -- Blastomycosis -- Botriomycosis -- Candidiasis -- Cestoda -- Chlamydiasis -- Coccidioidomycosis -- Cryptococcosis -- Cryptosporidiosis -- Cysticercosis -- Cytopathic effect -- Dirofilariasis -- Ecchinococcosis -- Enterobiasis -- False pathogens -- Fasciolasis -- Filariasis -- Fungal infections -- Fusariasis -- Giardiasis -- Granuloma -- Helminthiasis -- Herpes virus -- Histoplasmosis -- Human Immunodeficiency Virus -- Human Rickettsioses -- Hydatidosis -- Immunodeficiency -- Inflammatory reaction -- Influenza virus -- Isosporiasis -- Leishmaniasis -- Lobomycosis -- Malakoplakia -- Malaria -- Measles -- Microsporidiosis -- Mucormycosis -- Myasis -- Mycetomas -- Mycobacterial infections -- Mycoplasmasis -- Nematodes -- Nocardiosis -- Nontuberculous mycobacteria -- Onchocercosis -- Papillomavirus -- Paracoccidioidomycosis -- Paragonimiasis -- Parasitic infections -- Pentastomiasis -- Phaeohyphomycosis -- Pneumocystosis -- Polyomavirus -- Protothecosis -- Protozoa -- Respiratory syncitial virus -- Rhinoscleroma -- Rhinosporidiosis -- Sarcocytosis -- Scedosporiasis -- Sparganosis -- Sporothricosis -- Strongyloidiasis -- Taeniasis -- Toxoplasmosis -- Trematodes -- Trichinosis -- Trypanosomiasis -- Tuberculosis -- Tungiasis -- Viral Hepatitis -- Viral infections -- Whippleïs disease -- Yersiniasis -- Zygomycosis.
  • 2016From: Oxford Medicine Online
    edited by Ibrahim Abubakar, Helen R. Stagg, Ted Cohen, and Laura C. Rodrigues.
    This volume provides a concise reference for practicing epidemiologists, and provides trainee readers with a thorough understanding of basic the concepts which are critical to understanding specialist areas of infectious disease epidemiology.
  • edited by Kenrad E. Nelson, Carolyn Masters Williams.
    PrintStatus: Not Checked OutLane Catalog Record
    pt. 1. Methods in infectious disease epidemiology -- pt. 2. Airborne transmission -- pt. 3. Oral transmission of infection -- pt. 4. Blood and body fluid as a reservoir of infectious diseases -- pt. 5. Vector-borne and parasite diseases.
  • 2009From: Springer
    [edited by] Thomas T. Yoshikawa, Dean C. Norman.
    Concepts and principles of infections and aging -- Epidemiology of aging and infectious diseases -- Factors predisposing to infection -- Clinical features of infection -- Role and importance of functional assessment in infections -- Principles of antimicrobial therapy -- Common infections -- Sepsis -- Bronchitis and pneumonia -- Tuberculosis in older adults -- Infective endocarditis -- Intra-abdominal infections -- Infectious diarrhea -- Urinary tract infection -- Bacterial meningitis and brain abscess -- Osteomyelitis and septic arthritis -- Skin and soft tissues infections -- Herpes zoster -- Orofacial and odontogenic infections in the elderly -- Ocular infections -- Otitis externa, otitis media, and sinusitis -- Prosthetic joint infections in elderly patients -- Staphylococcal and enterococcal infections -- Fungal infections -- Viral infections -- Unique infectious disease problems -- Infections in the long-term care setting -- Infection control programs in nursing homes -- Infections in diabetes -- Vaccinations -- Nutrition and infection -- Sexually transmitted diseases -- Human immunodeficiency virus/acquired immunodeficiency syndrome -- SARS and West Nile virus.
  • 2010From: Springer
    Vitali Sintchenko, editor.
    Informatics for infectious disease research and control -- Bioinformatics of microbial sequences -- Mining databases for microbial gene sequences -- Comparative genomics of pathogens -- Systems microbiology: gaining insights in transcriptional networks -- Host-pathogen systems biology -- Text mining for discovery of host-pathogen interactions -- Network approach to understanding pathogen population structure -- Computational epitope mapping -- Pangenomic reverse vaccinology -- Immunoinformatics: the next step in vaccine design -- Understanding the shared bacterial genome -- Computational grammars for interrogation of genomes -- In silico discovery of chemotherapeutic agents -- Informatics for healthcare epidemiology -- Automated, high-throughput surveillance systems for public health -- Microbial genotyping systems for infection control -- Temporal and spatial clustering of bacterial genotypes -- Infectious disease ontology -- Populations, patients, germs and genes: ethics of genomics and informatics in communicable disease control.
  • 2013From: Wiley
    edited by Nkuchia M'ikanatha, Ruth Lynfield, Chris A. Van Beneden, Henriette de Valk.
    This fully updated edition of Infectious Disease Surveillance is for frontline public health practitioners, epidemiologists, and clinical microbiologists who are engaged in communicable disease control. It is also a foundational text for trainees in public health, applied epidemiology, postgraduate medicine and nursing programs. The second edition portrays both the conceptual framework and practical aspects of infectious disease surveillance. It is a comprehensive resource designed to improve the tracking of infectious diseases and to serve as a starting point in the developme.
  • Frederick S. Southwick, Professor of Medicine, Division of Infectious Diseases, University of Florida College of Medicine, Gainesville, Florida.
    PrintStatus: Not Checked OutLane Catalog Record
    Anti-infective therapy -- The sepsis syndrome -- The febrile patient -- Pulmonary infections -- Eye, ear, nose, and throat -- Central nervous system infections -- Cardiovascular infections -- Gastrointestinal and hepatobiliary infections -- Gastrointestinal tract infections and sexually transmitted diseases (STDs) -- Skin and soft tissue infections -- Bone and joint infections -- Parasitic infections -- Zoonotic infections -- Bioterrorism -- Serious adult viral illnesses other than HIV -- Infections in the immunocompromised host -- HIV infection.
  • 2013From: Springer
    Phyllis Kanki, Darrell Jay Grimes, editors.
    Infectious Diseases: Selected Entries from the Encyclopedia of Sustainability Science and Technology presents authoritative, peer-reviewed contributions from leading experts on a wide range of major infectious diseases of global importance. Infectious diseases account for more than 17 million deaths each year worldwide. While modern medicine and technology have diminished the threat of many of these pathogens in high-income countries, the ever present threats of re-emerging infections, population mobility, natural disasters, and pathogen genetic variability are but some of the reasons for the dynamic threat of this broad category of risks to human health. An indispensable resource for students and scientists, the volume also covers some of the new technologies currently under development for infectious disease prevention, treatment, and eradication. The greater part of the infectious disease burden remains in the tropics, where low and middle-income countries lack the resources, infrastructure, and health systems to mount or sustain control efforts. Many contributions describe the efforts of the scientific research community and international donor agencies to achieve the integrated goals of vigilant surveillance, improved and cost-effective diagnostics, and treatment for sustainable disease control.Describes the dynamic nature of infectious disease agents and their complex interactions with the environment and their human and animal hosts Covers new technologies for antibiotics, vaccines, and treatment Features several contributions on waterborne infectious diseases, including enteric viruses and bacterial pathogens in the ocean Provides an excellent introduction for those entering the field, as well as new insights for advanced researchers and industry experts
  • 2014From: Springer
    v. 2From: Springer
    Rameshwar Adhikari, Santosh Thapa, editors.
    The volumes address the interdisciplinary scientific approach for the systemic understanding of connections between major human diseases and their treatment regime by applying the tools and techniques of nanotechnology. It also highlights the interdisciplinary collaborative researches for innovation in Biomedical Sciences.
    Also available: Print – v. 1-2, 2014.
  • 2007From: CRCnetBASE
    [edited by] Elliott R. Jacobson.
  • 2016From: Springer
    Fingani Annie Mphande.
    Chapter 1: Poverty, Health and Livelihoods -- Chapter 2: Rural Livelihood -- Chapter 3: Infectious Diseases -- Chapter 4: Infectious Diseases and Livelihoods -- Chapter 5: Transportation -- Chapter 6: Healthcare -- Chapter 7: Surveillance -- Chapter 8: Disease Awareness and Prevention -- Chapter 9: Infectious Disease Management Strategies -- Chapter 10: Way Forward -- Bibliography -- Index.
  • 2007From: Springer
    J. Rello ... [et al.], (eds.).
    Approach to the febrile patient in the intensive care unit -- Cardiovascular monitoring in severe sepsis or septic shock -- Cardiopulmonary resuscitation and infection -- Opportunistic infections in the intensive care unit: a microbiologic overview -- Infections in critically ill solid organ transplant patients -- HIV in the intensive care unit -- Fungal infections -- Using protocols to improve the outcomes of critically ill patients with infection: focus on ventilator-associated pneumonia and severe sepsis -- Microbial surveillance in the intensive care unit -- Antimicrobial prophylaxis in the intensive care unit -- Antifungal therapy in the intensive care unit -- Dose adjustment and pharmacokinetics of antibiotics in severe sepsis and septic shock -- Prescription of antimicrobial agents in patients undergoing continuous renal replacement therapy -- Methods for implementing antibiotic control in the intensive care unit -- Use of antibiotics in pregnant patients in the intensive care unit -- Immunomodulation in sepsis -- Antibiotic induced diarrhea -- Fundamentals of infection control and strategies for the intensive care unit -- Antibiotic resistance in the intensive care unit -- Epidemiology of pseudomonas aeruginosa in the intensive care unit -- How to control MRSA spread in the intensive care unit -- Epidemiology of acinetobacter baumannii in the intensive care unit -- Brain abscess -- Falciparum malaria -- Toxic shock syndromes -- Acute infective endocarditis -- Influenza -- Bloodstream infection in the intensive care unit -- Bloodstream infections in patients with total parenteral nutrition catheters -- Hemodialysis catheter-related infections -- Infection of pulmonary arterial and peripheral arterial catheters -- Prevention of catheter-related bloodstream infections in critical care patients -- Meningococcemia -- Septic shock -- Tracheobronchitis in the intensive care unit -- Sever community-acquired pneumonia -- Legionnaires' disease -- Adjunctive and supportive measures for community-acquired pneumonia -- Respiratory infection in immunocompromised neutropenic patients -- Pneumonia in non-neutropenic immunocompromised patients -- Community-acquired respiratory complications in the intensive care unit: pneumonia and acute exacerbations of COPD -- Management of hospital-associated pneumonia in the intensive care unit -- Assessment of resolution of ventilator associated pneumonia -- Invasive devices in the pathogenesis of nosocomial pneumonia -- Multiple organ dysfunction syndrome -- Sepsis in obstetrics -- Diagnosis and management of intra-abdominal sepsis -- Surgical site infection control in the critical care environment -- Severe soft tissue infections: a syndrome-based approach -- Vascular graft infections -- Acute mediastinitis -- Pancreatic infection -- Urinary tract infections -- Neurosurgical infections in intensive care unit patients -- Biliary tract infections.
  • 2016From: Springer
    Tulio A. Valdez, Jesus G. Vallejo, editors.
    I. Ears -- 1. Management of the Child with Otorrhea -- 2. Infections of the External Ear -- 3. Otitis Media -- 4. Complications of Acute and Chronic Otitis Media -- 5. Inner Ear Infections -- II. Nasal Cavity and Sinuses -- 6. Nasal Soft Tissue Infections -- 7. Sinusitis -- 8. Complications of Sinusitis -- 9. Sinus Disease in Cystic Fibrosis -- III. Oral Cavity, Oropharynx and Upper Airway -- 10. Tonsillitis and Peritonsillar Abscess -- 11. Laryngeal Infections -- 12. Tracheal Infections -- IV. Neck -- 13. Infectious Lymphadenopathy -- 14. Neck Abscesses and Deep Neck Infections -- 15. Infected Congenital Neck Lesions -- V. Other Conditions -- 16. PFAPA: Periodic Fever, Aphthous Stomatitis, Pharyngitis, and Cervical Adenitis.
  • "THE INFECTIOUS DISEASES OF HAITI is one in a series of GIDEON e-books which summarize the status of individual infectious diseases, in every country of the world. Data are based on the GIDEON database ( which relies on standard text books, peer-review journals, Health Ministry reports and ProMED, supplemented by an ongoing search of the medical literature. Chapters are arranged alphabetically, by disease name. Each section is divided into four sections: 1. Descriptive epidemiology; 2. Summary of clinical features; 3. Status of the disease in Haiti ; 4. References. The initial items in the first section, Descriptive epidemiology, are defined as follows: Agent: Classification (e.g., virus, parasite) and taxonomic designation; Reservoir: Any animal, arthropod, plant, soil or substance in which an infectious agent normally lives and multiplies, on which it depends primarily for survival, and where it reproduces itself in such a manner that it can be transmitted to a susceptible host; Vector: An arthropod or other living carrier which transports an infectious agent from an infected organism or reservoir to a susceptible individual or immediate surroundings; Vehicle: The mode of transmission for an infectious agent. This generally implies a passive and inanimate (i.e., non-vector) mode. There are 347 generic infectious diseases in the world today. 198 of these are endemic, or potentially endemic, to Haiti. A number of other diseases are not relevant to Haiti and have not been included in this book. In addition to endemic diseases, we have included all published data regarding imported diseases and infection among expatriates from this country. The availability and quality of literature regarding specific infectious diseases varies from country to country. As such, you may find that many of the sections in this book are limited to a general discussion of the disease itself - with no data regarding the country under review. Since this book focuses on Geographic Medicine, it does not include detailed information on diagnostic testing, pathogenesis, therapy or molecular biology. Many of the diseases are generic. For example, such designations as Pneumonia bacterial and Urinary tract infection include a number of individual diseases. These appear under the subheading, Synonyms, listed under each disease. The entire book will be updated on a regular basis.
  • [edited by] Jack S. Remington, Jerome O. Klein, Christopher B. Wilson, Victor Nizet, Yvonne A. Maldonado.
    PrintStatus: Not Checked OutLane Catalog Record
  • 2004From: Ovid
    edited by Sherwood L. Gorbach, John G. Bartlett, Neil R. Blacklow.
    Also available: Print – 2004
  • 2010From: ClinicalKey
    edited by Jonathan Cohen, Steven M. Opal, William G. Powderly ; section editors, Thierry Calandra ... [et al.].
    Also available: Print – v. 1-2, 2010.
  • Kyle A. Beauchamp.
    An atomic-scale understanding of biological molecules remains a grand challenge for the physical and biological sciences. Here, I describe how molecular dynamics simulations can be used to directly connect to biophysical experiments. I first describe the use of Markov state models to connect simulated and measured protein kinetics, allowing studies of protein folding at the atomic scale. I then introduce the use of NMR measurements, such as chemical shifts and scalar couplings, for the evaluation of molecular dynamics force field quality. Finally, I propose a new statistical technique that can be used to combine both simulation and experiment into accurate models of conformational ensembles. Such models are shown to be free of force field bias and can be used to investigate the structural and equilibrium properties of biomolecules. In sum, the present work demonstrates how statistically-sound methods of inference can forge a direct connection between simulation and experiment.
  • Jeffrey A. Lockwood.
    PrintStatus: Not Checked OutLane Catalog Record
    Exploring the nature of anxiety and phobia, Lockwood explores the lively debate about how much of our fear of insects can be attributed to ancestral predisposition for our own survival and how much is learned through individual experiences. Drawing on vivid case studies, Lockwood explains how insects have come to infest our minds in sometimes devastating ways and supersede even the most rational understanding of the benefits these creatures provide.
  • 2013From: Springer Protocols
    edited by Christine M. De Nardo and Eicke Latz.
    Assessing [beta]-amyloid-induced NLRP3 inflammasome activation in primary microglia / Mareike Schnaars, Hannes Beckert, and Annett Halle -- Activating the NLRP3 inflammasome using the amyloidogenic peptide IAPP / Clara Westwell-Roper [and others] -- Assessment and quantification of crystal-induced lysosomal damage / Peter Duewell and Eicke Latz -- Assessment of inflammasome activation in primary human immune cells / Theo S. Plantinga, Leo A.B. Joosten, and Mihai G. Netea -- NLRP3 inflammasome activation and cytotoxicity induced by particulate adjuvants / Marie Yang [and others] -- Measuring inflammasome activation in response to bacterial infection / Petr Broz and Denise M. Monack -- Detection of pyroptosis by measuring released lactate dehydrogenase activity / Manira Rayamajhi, Yue Zhang, and Edward A. Miao -- ASC speck formation as a readout for inflammasome activation / Andrea Stutz [and others] -- Immunoblotting for active caspase-1 / Christopher Jakobs [and others] -- Inflammasome activation and inhibition in primary murine bone marrow-derived cells, and assays for IL-1[alpha], IL-1[beta], and caspase-1 / Katharina S. Schneider, Christina J. Thomas, and Olaf Gross -- Reconstituting the NLRP1 inflammasome in vitro / Benjamin Faustin and John C. Reed -- Assessing ATP binding and hydrolysis by NLR proteins / Jinyao Mo and Joseph A. Duncan -- Blue native polyacrylamide gel electrophoresis to monitor inflammasome assembly and composition / Eric M. Kofoed and Russell E. Vance -- Analysis of microbiota alterations in inflammasome-deficient mice / Eran Elinav, Christoph A. Thaiss, and Richard A. Flavell -- Quantification of adipose tissue leukocytosis in obesity / Ryan Grant [and others] -- In vivo evaluation of neutrophil recruitment in response to sterile particulates / Tamiko Yanagida, Kaoru Orihashi, and Hajime Kono.
  • 2016From: Springer
    edited by Steffen Backert, editor.
    This volume details our current understanding of the architecture and signaling capabilities of known canonical and non-canonical inflammasome complexes and highlights their action, in particular in response to infection with important bacterial model organisms and the corresponding disease pathologies. The first chapters review new insights into the assembly and structures of inflammasome components and emphasize general strategies of up- and downstream signaling events. In addition, the authors specifically discuss the composition and activity of inflammasomes during infection with various gut pathogens (Salmonella, Shigella, Yersinia, Listeria and Helicobacter), respiratory pathogens (Mycobacterium, Legionella, Burkholderia and Streptococcus) as well as skin and soft tissue pathogens (Francisella and Staphylococcus). The discoveries presented provide a better understanding of the cellular and molecular biology of inflammasomes, which will pinpoint important new therapeutic targets for the treatment and prevention of multiple infectious diseases in the future.
  • 2011From: Springer
    Isabelle Couillin, Virginie Pétrilli, Fabio Martinon, editors.
  • 2014From: ScienceDirect
    edited by Irfan Rahman, Debasis Bagchi.
    The book provides a comprehensive overview to understanding the integrated impact of the concepts of cellular and molecular aspects, models, environmental factors, and lifestyle involved in premature aging. Additionally, it examines how functional food, dietary nutraceuticals or pharmacological compounds can reverse inflammation and premature aging based on personalized medicine. This book is a valuable resource for health professionals, scientists and researchers, nutritionists, health practitioners, students and for all those who wish to broaden their knowledge in the allied field.
  • 2012From: Springer
    Georg Wick, Cecilia Grundtman, [editors].
    Ch. 1. Historical reflections on the inflammatory aspects of atherosclerosis -- Ch. 2. Morphology of atherosclerotic lesions -- Ch. 3. Clinical manifestations of atherosclerosis -- Ch. 4. Intra-aortic hematopoietic cells -- Ch. 5. The vascular-associated lymphoid tissue (VALT) -- Ch. 6. Vascular endothelial cells as immunological targets in atherosclerosis -- Ch. 7. The role of adhesion molecules and intimal dendritic cells in the initiation of atherosclerosis -- Ch. 8. Animal models of atherosclerosis -- Ch. 9. A Darwinian-evolutionary concept for atherogenesis: the role of immunity to HSP60 -- Ch. 10. Mediators of vascular inflammation -- Ch. 11. Pentraxins and atherosclerosis -- Ch. 12. Interleukin-33 and atherosclerosis -- Ch. 13. Proteomics of atherosclerosis -- Ch. 14. Adipokines, inflammation, and atherosclerosis -- Ch. 15. Natural antibodies and atherosclerosis -- Ch. 16. NK/NKT cells and atherosclerosis -- Ch. 17. Macrophages and atherosclerosis -- Ch. 18. Host pattern recognition receptors (toll-like receptors, RIG-I-Like receptors, NOD-like receptors) and atherosclerosis -- Ch. 19. Humoral antibodies -- Ch. 20. Adaptive T Cell immunity -- Ch. 21. Immunity to low-density lipoprotein -- Ch. 22. Extracellular matrix and smooth muscle cells -- Ch. 23. The role of infection in atherosclerosis and in plaque stability -- Ch. 24. Inflammatory biomarkers -- Ch. 25. Atherosclerosis in rheumatic diseases -- Ch. 26. Anti-inflammatory therapeutic approaches -- Ch. 27. Vaccination against atherosclerosis -- Ch. 28. Endocrinological aspects of atherosclerosis -- Ch. 29. Imaging of atherosclerosis -- Ch. 30. Future directions of atherosclerosis research and translation into clinical application -- Ch. 31. Controversies and open questions -- Index.
  • 2014From: Springer
    Bharat B. Aggarwal, Bokyung Sung, Subash Chandre Gupta, editors.
    The role of inflammation in lung cancer / Mónica Gomes, Ana Luísa Teixeira, Ana Coelho, António Araújo and Rui Medeiros -- The role of inflammation in colon cancer / Naveena B. Janakiram and Chinthalapally V. Rao -- The role of inflammation in inflammatory breast cancer / Tamer M. Fouad, Takahiro Kogawa, James M. Reuben and Naoto T. Ueno -- The role of inflammation in brain cancer / James L. Sowers, Kenneth M. Johnson, Charles Conrad, Joel T. Patterson and Lawrence C. Sowers -- The role of inflammation in head and neck cancer / Marcelo Bonomi, Alexis Patsias, Marshall Posner and Andrew Sikora -- The role of inflammation in pancreatic cancer / Simone Hausmann, Bo Kong, Christoph Michalski, Mert Erkan and Helmut Friess -- The role of inflammation in prostate cancer / Karen S. Sfanos, Heidi A. Hempel and Angelo M. De Marzo -- The role of inflammation in bladder cancer / Georgios Gakis -- The role of inflammation in kidney cancer / Antonio Roma De Vivar Chevez, James Finke and Ronald Bukowski -- The role of inflammation in gastric cancer / Kazim Senol, Murat Bulut Özkan, Selahattin Vural and Mesut Tez -- The role of inflammation in sarcoma / Jürgen Radons -- The role of inflammation in lymphoma / Antonino Carbone, Claudio Tripodo, Carmelo Carlo-Stella, Armando Santoro and Annunziata Gloghini -- The role of inflammation in leukaemia / Janusz Krawczyk, Michael O'Dwyer, Ronan Swords, Ciara Freeman and Francis J Giles -- The role of inflammatory cells in angiogenesis in multiple myeloma / Domenico Ribatti and Angelo Vacca -- The role of inflammation in cervical cancer / S. Deivendran, K. Hezlin Marzook and M. Radhakrishna Pillai -- The role of inflammation in liver cancer / Anupam Bishayee -- The role of inflammation in skin cancer / Girish B. Maru, Khushboo Gandhi, Asha Ramchandani and Gaurav Kumar.
    Also available: Print – 2014
  • v. 1-2, 2009From: Springer Protocols
    v. 2, 2009From: Springer Protocols
    edited by Serguei V. Kozlov.
    v. 1. Experimental models and practical approaches -- v. 2. Molecular analysis and pathways.
  • 2011From: Springer
    Janusz A.Z. Jankowski, editor.
    Basic concepts of inflammation and its role in carcinogenesis -- Inherited syndromes predisposing to inflammation and GI cancer -- Stem cells and inflammation in the intestine -- Acid reflux and oesophageal cancer -- Helicobacter pylori and gastric cancer -- Inflammatory bowel disease and colon cancer -- Primary sclerosing cholangitis -- Chronic inflammation and hepatocellular carcinoma -- Gastrointestinal cancer: current screening strategies -- Targeted drug therapies and cancer -- Genetics of inflammation in the gastrointestinal tract and how it can cause cancer -- Endoscopic methods.
  • 2010From: Springer
    John D. Lambris, Anthony P. Adamis, editors.
    The case for complement and inflammation in AMD : open questions / Natalia Karagianni and Anthony P. Adamis -- The role of complement in AMD / Peter F. Zipfel, Nadine Lauer, and Christine Skerka -- Multiple interactions of complement factor H with its ligands in solution : a progress report / Stephen J. Perkins ... [et al.] -- Genetic control of complement activation in humans and age related macular degeneration / Laura A. Hecker and Albert O. Edwards -- Bisretinoids of RPE lipofuscin : trigger for complement activation in age-related macular degeneration / Janet R. Sparrow -- The role of the classical complement cascade in synapse loss during development and glaucoma / Allison M. Rosen and Beth Stevens -- A role for complement in glaucoma? / Lizhen Ren and John Danias -- The ATP-binding cassette transporter ABCA4 : structural and functional properties and role in retinal disease / Yaroslav Tsybovsky, Robert S. Molday, and Krzysztof Palczewski -- Suppression of drusen formation by compstatin, a peptide inhibitor of complement C3 activation, on cynomolgus monkey with early-onset macular degeneration / Zai-Long Chi ... [et al.] -- A targeted inhibitor of the complement alternative pathway reduces RPE injury and angiogenesis in models of age-related macular degeneration / Bärbel Rohrer ... [et al.] -- Complement depletion with humanized cobra venom factor in a mouse model of age-related macular degeneration / David C. Fritzinger ... [et al.]
    Also available: Print – 2010
  • 2014From: Springer
    Madhavi Thomas, editors.
    Inflammation in Parkinson's Disease brings advances in research together with current literature and evidence. This concise volume covers the fundamentals of neuroimmunology and inflammatory models, the interactions between pathways of neurodegeneration and follows the concept of research work undertaken from basic science to clinical trials. Researchers, clinicians, and students interested in Parkinson's Disease are provided with a comprehensive view of translational research methods and an insight needed for developing future therapies aimed at disease modulation.
  • 2013From: Karger
    volume editors, A. Halaris, Maywood, Ill., B.E. Leonard, Galway.
    Basic aspects of the immunology of neuroinflammation / Wohleb, E.S.; Godbout, J.P. -- Stress and neuroinflammation / Grippo, A.J., Scotti, M.-A.L. -- Role of inflammation in depression : implications for phenomenology, pathophysiology and treatment / Raison, C.L., Miller, A.H. -- Virus infection as a cause of inflammation in psychiatric disorders / Bechter, K. -- Inflammation, neurotoxins and psychiatric disorders / Myint, A.-M. -- Essential fatty acids as potential anti-inflammatory agents in the treatment of affective disorders / Song, C. -- The brain-gut axis : a target for treating stress-related disorders / Scott, L.V., Clarke, G., Dinan, T.G. -- The question of pro-inflammatory immune activity in schizophrenia and the potential importance of anti-inflammatory drugs / Arolt, V., Ambrée, O. -- Inflammation as the cause of the metabolic syndrome in depression / Leonard, B.E. -- Glucocorticoids and inflammation : a double-headed sword in depression? / Horowitz, M.A. ... [et al.] -- Co-morbidity between cardiovascular pathology and depression : role of inflammation -- Halaris, A. -- Inflammatory and oxidative and nitrosative stress cascades as new drug targets in myalgic encephalomyelitis and chronic fatigue syndrome -- Maes, M. -- Peripheral inflammation and cognitive aging -- Lim, A., Krajina, K., Marsland, A.L. -- Inflammation in suicidality : implications for novel treatment options / Janelidze, S., Brundin, L.
  • 2007From: Springer
    edited by Randall E. Harris.
  • 2012From: CRCnetBASE
    edited by Bharat B. Aggarwal, Sunil Krishnan, Sushovan Guha.
    "Oxidative stress and inflammation are among the most important factors of disease. Chronic infections, obesity, alcohol and tobacco usage, radiation, environmental pollutants, and high-calorie diets have been recognized as major risk factors for a variety of chronic diseases from cancer to metabolic diseases. All these risk factors are linked to chronic diseases through inflammation. While short-term, acute inflammation generated by the immune system serves a therapeutic role, chronic low-level inflammation that may persist "silently" for decades is responsible for chronic diseases. Inflammation, Lifestyle, and Chronic Diseases: The Silent Link describes the role of dysregulated inflammation in persistent and recurring diseases. It investigates links to lifestyle and presents research on how the suppression of proinflammatory pathways may provide opportunities for both prevention and treatment of chronic diseases. The book covers neurodegenerative diseases, pulmonary diseases, asthma, rheumatic and arthritic diseases, skin disease, heart disease, chronic wounds, infectious disease, neuropsychiatric disorders such as depression, gastrointestinal diseases, insulin resistance, and cancer, many of which are also diseases of old age. For each chronic disease, contributors review the clinical and scientific literature and examine current and potential therapies, including conventional pharmacotherapies as well as natural products. Noting that the long-term use of steroids and nonsteroidal anti-inflammatory drugs (NSAIDs) can cause adverse side effects, many of the chapters address the role of dietary agents such as fruits, vegetables, legumes, pulses, nuts, and spices as ideal anti-inflammatory agents that can be consumed regularly. The book also suggests directions for further research. Clinical and science researchers, students, and health professionals interested in the link between inflammation, lifestyle, and chronic diseases will find this an informative resource"--Provided by publisher.
  • 2014From: CRCnetBASE
    editor, Ah-Ng Tony Kong.
    Section I. Inflammation, oxidative stress, nutritional phytochemicals, and cancer -- section II. Signal transduction, molecular targets, and biomarkers of dietary cancer-preventive phytochemicals -- section III. In vivo absorption and pharmacokinetics of nutritional phytochemicals -- section IV. Vitamins A, D, and E cancer prevention and clinical perspective -- section V. Omega-3 and omega-6 fatty acids -- section VI. Flavonoids and polyphenols -- section VII. Garlic organosulfur compounds and crucifer glucusinolates -- section VIII. Selenium, herbal medicines, alpha lipoic acid, and cancer prevention -- section IX. Epigenetics and chronic inflammation.
  • 2015From: Springer
    Ian C. Scott, James B. Galloway, David L. Scott.
    This evidence based book covers the key components in the diagnosis, assessment and management of inflammatory arthritis. The authors look at the epidemiology, pathology, clinical assessment and investigation of inflammatory arthritis patients, and provide an overview of currently available treatment options. With major changes seen in the way inflammatory arthropathies are diagnosed, classified, investigated and managed, Inflammatory Arthritis in Clinical Practice, Second Edition provides the reader with the most up-to-date developments in this area.
  • 2011From: Springer
    Russell D. Cohen, editor.
    The influence of twentieth-century biomedical thought on the origins of inflammatory bowel disease therapy / Joseph B. Kirsner -- The changing epidemiology of IBD / Anders Ekbom -- Recent advances in the genetics of IBD / Russell D. Cohen -- New paradigms in the pathogenesis of IBD / Giorgos Bamias, Theresa Pizarro, and Fabio Cominelli -- State of the art medical treatment of the adult patient with IBD : the mesalamine-based therapies / L. Campbell Levy and Corey A. Siegel -- State of the art medical treatment of the adult patient with IBD : modern use of corticosteroids / Wojciech Blonski, David Kotlyar, and Gary R. Lichtenstein -- State-of-the-art medical therapy of the adult patient with IBD : the immunomodulators / Dana Moffatt and Charles N. Bernstein -- State-of-the-art medical treatment of the adult patient with IBD : the biological therapies / Stephen B. Hanauer -- Prebiotics, probiotics, antibiotics, and nutritional therapies in IBD / Richard N. Fedorak, Levinus A. Dieleman, and Karen L. Madsen -- State-of-the-art management of the pediatric IBD patient / Marla Dubinsky -- Innovations in the surgical treatment of inflammatory bowel disease / Roger Hurst -- Clinical utility of serological markers and thiopurine drug monitoring in IBD : an evidence-based review / Raja Tamaz and Ernest G. Seidman -- Caring for women with inflammatory bowel disease / Sunanda Kane and Rebecca Kowalczyk -- Novel radiographic techniques in IBD patients / V. Anik Sahni and Koenraad J. Mortele -- Novel techniques in the diagnosis of inflammatory bowel disease / Shabana F. Pasha and Jonathan A. Leighton -- Inflammatory bowel disease pathology slideshow / Christopher R. Weber -- New findings in the diagnosis and prevention of colorectal cancer in IBD / David T. Rubin and Jami A. Rothe -- Managing the patient with a fecal diversion / Janice C. Colwell -- The new economic reality in the world of IBD / Nanda Venu and Russell D. Cohen.
  • 2015From: Springer
    Daniel J. Stein, Reza Shaker, editors.
  • 2006From: Springer
    Gian Gaetano Delaini (ed.) ; foreword by S.M. Goldberg.
    Also available: Print – 2006
  • 2013From: Springer
    Jaime G. de la Garza-Salazar, Abelardo Meneses-Garcia, Claudia Arce-Salinas, editors.
    Inflammatory breast cancer is a rare and aggressive form of breast cancer that occurs in women of all ages, and, rarely, in men. Variable disease presentation means that this disease is often undetected and patients with this diagnosis have a poor prognosis.Inflammatory Breast Cancer brings together the existing clinical information on inflammatory breast cancer. The content covers epidemiology, risk factors, diagnosis, histopathology and staging, therapy and management of patients with this disease. Recent advances in therapy have improved the prognosis of this type of cancer considerably, making this text a timely addition to the literature.This book is an essential tool for medical, surgical and clinical oncologists specialising in breast cancer, who will inevitably encounter this rare but pernicious disease.
  • 2012From: Springer
    Naoto T. Ueno, Massimo Cristofanilli, editors.
    Introduction: Why IBC Now? / Naoto T. Ueno and Massimo Cristofanilli -- Epidemiology of Inflammatory Breast Cancer / Shannon Wiggins, Sarah Taylor and Melissa Bondy -- Clinical Aspect of Inflammatory Breast Cancer: Diagnosis, Criteria, Controversy / Shaheenah Dawood and Vicente Valero -- Inflammatory Breast Cancer Registry / Jie S. Willey and Naoto T. Ueno -- Pathology: Histomorphometrical Features of IBC - Angiogenesis, Lymphangiogenesis, and Tumor Emboli / Sanford H. Barsky and Fredika M. Robertson -- Imaging for the Diagnosis and Staging of IBC / Wei Tse Yang -- Surgical Therapy for Inflammatory Breast Cancer / Sarah M. Gainer, Hideko Yamauchi and Anthony Lucci -- Radiation Therapy for Inflammatory Breast Cancer / Thomas A. Buchholz, Ian Bristol and Wendy Woodward -- Systemic and Targeted Therapy / Hideko Yamauchi, Teruo Yamauchi, Naoto T. Ueno and Vicente Valero -- Inflammatory Breast Cancer: Chemotherapy of Metastatic Disease / Anthony Gonçalves and Patrice Viens -- The Role of the Multidisciplinary Team in Inflammatory Breast Cancer / Nabila Chowdhury and Sandra M. Swain -- High-Dose Chemotherapy with Autologous Hematopoietic Stem Cell Transplantation in Inflammatory Breast Cancer / Yee Chung Cheng and Naoto T. Ueno -- Models of Inflammatory Breast Cancer / Lara Lacerda and Wendy A. Woodward -- Signaling Pathways in Inflammatory Breast Cancer / Dongwei Zhang and Naoto T. Ueno -- Molecules That Drive the Invasion and Metastasis of Inflammatory Breast Cancer / Madhura Joglekar and Kenneth L. van Golen -- Inflammatory Mediators as Therapeutic Targets for Inflammatory Breast Cancer / Fredika M. Robertson, Khoi Chu, Rita Circo, Julia Wulfkuhle and Lance Liotta, et al. -- Immunology of Inflammatory Breast Cancer / James M. Reuben and Bang-Ning Lee -- Angiogenesis and Lymphangiogenesis in IBC: Insights from a Genome-Wide Gene Expression Profiling Study / Peter B. Vermeulen, Gert Van den Eynden, Pascal Finetti, Daniel Birnbaum and Naoto T. Ueno, et al. -- Microarray Analysis Identifies an Expression Signature for Inflammatory Breast Cancer / François Bertucci, Pascal Finetti, Max Chaffanet, Patrice Viens and Daniel Birnbaum -- Cell Gene Expression Signatures in Inflammatory Breast Cancer / Wendy A. Woodward -- The Effect of Systemic Chemotherapy on Minimal Residual Disease in the Blood and Bone Marrow of Patients with Inflammatory Breast Cancer / Luc Y. Dirix, Dieter Peeters, Steven Van Laere and Peter B. Vermeulen -- Perspective of Patient Advocacy / Michelle Esteban and Patti Bradfield.
  • Heinz-Peter Schultheiss, Michel Noutsias, editors.
    PrintStatus: Not Checked OutLane Catalog Record
  • 2016From: Springer
    Steven D. Billings, Jenny Cotton.
  • 2011From: Springer
    Steven D. Billings, Jenny Cotton.
    Spongiotic dermatitis -- Psoriasiform dermatitis -- Interface dermatitis -- Perivascular dermatitis -- Vasculitis and thrombotic disorders -- Nodular and diffuse dermatitis -- Palisading granulomatous dermatitis -- Sclerosing dermatitis -- Bullous dermatitis -- Panniculitis -- Infections -- Miscellaneous dermatoses: invisible dermatoses and inflammatory processes that clinically mimic tumors.
  • 2010From: Springer
    Bruce R. Smoller and Kim M. Hiatt.
    Superficial perivascular dermatitis -- Lichenoid/vacuolar dermatitis -- Superficial perivascular dermatitis with spongiotic epidermal changes -- Superficial perivascular dermatitis with psoriasiform epidermal changes -- Superepidermal blistering processes -- Intraepidermal blisters -- Granulomatous dermatitis -- Cutaneous vasculitis -- Alopecias -- Panniculitis -- Histologic mimics of cutaneous lymphoma -- Dermal pigmentary disorders -- Dermal deposition disorders without pigment.
  • 2012From: Wiley
    edited by Gary S. Hoffman, Cornelia M. Weyand, Carol A. Langford, Jörg J. Goronzy.
  • 2013From: Springer
    volume editor, Stefan Hähnel.
    Inflammatory diseases of the CNS are playing an increasingly important role in the clinical practice of neuroradiology. Neuroimaging contributes greatly to the differentiation of infectious (e.g., viral encephalitis and pyogenic brain abscess) and noninfectious (e.g., multiple sclerosis) inflammatory brain diseases and to the distinction between brain inflammation and other brain diseases, e.g., neoplastic or ischemic. This second, updated edition of Inflammatory Diseases of the Brain provides a comprehensive overview of the field from a neuroradiological point of view. In order to ensure a standardized approach throughout the book, each disease-oriented chapter is again subdivided into three principal sections: epidemiology, clinical presentation, and therapy; imaging; and differential diagnosis. A separate chapter addresses technical and methodological issues and imaging protocols. An important focus of the book is the current role of advanced MR imaging techniques, such as diffusion and perfusion MRI and MR spectroscopy, in the differentiation of inflammatory and other brain diseases. All of the authors are recognized experts, and the numerous high-quality and informative illustrations include some not contained in the first edition. This book will be of great value not only to neuroradiologists but also to neurologists, neuropediatricians, and general radiologists.
  • 2015From: Springer
    Mieczyslaw Pokorski, editor.
    The mechanistic basis of chronic inflammation remains unclear. The research sheds new light on the immune cells expressing the activation markers HLA-DR and regulatory T cells (Tregs) and the cells expressing Siglec receptors as being key players in the immune system responsiveness to antigens and thus in lung tissue damage of chronic inflammation. The results help understand the mechanisms of action of common drugs used in COPD, such as formoterol, tiotropium, or corticosteroids, and point to novel drug targets. The chapters also deal with brain damaging effects, by far unrecognized, of inhaled corticosteroid therapy, a time-proven management of chronic inflammatory airway conditions; asthma being a case in point. Novel methods, likely less producing side effects, of macrolide antibiotics administration by inhalation are discussed, emphasizing not only bacteriostatic but also anti-inflammatory action.
    Also available: Print – 2015
  • 2009From: Springer
    Lawrence J. Kagen, editor.
    Evaluation of the patient -- Classification of idiopathic inflammatory myopathies -- Inflammatory milieu: cells and cytokines -- Juvenile dermatomyositis: an update on clinical and laboratory findings -- Inclusion body myositis -- Role of muscle biopsy in the diagnosis of inflammatory myopathy -- Electromyography -- Magnetic resonance imaging of myopathies and myositis -- Ultrasound in the evaluation of the inflammatory myopathies -- Serological findings -- Antisynthetase syndrome -- Pulmonary manifestations of inflammatory myopathy -- Dermatological manifestations of dermatomyositis -- Differential diagnosis of inflammatory myopathy -- Outcomes and assessment for inflammatory muscle disease -- Muscle strength and exercise in patients with inflammatory myopathies -- Risk of malignancy in patients with dermatomyositis and polymyositis -- Treatment.
  • 2015From: Springer
    Michael Pugia, editor.
    Part 1. Introduction -- 1. Impact of inflammation and the innate immunity response in obesity mediated diabetes (lit review) -- Part 2. Impact of complement on diabetic disease -- 2. Complement and Complement Regulatory Proteins in Diabetes -- Part 3. Role of C terminal fragment of adiponectin receptor in inhibition of insulin degradation -- 3. Development of adiponectin receptor C terminal fragment bioassays -- 4. Protease inhibition and biological distribution of the C terminal fragment of adiponectin receptor -- 5. Cell & biological models for the C terminal fragment of adiponectin receptor -- 6. C-Terminal fragment of adiponectin receptor clinical correlations -- Part 4. Uristatin assay for prediction of renal and other clinical events -- 7. Uristatin immunoassay usage in glomerular nephritis assessment -- 8. Acute Response of Uristatin in Surgery -- 9. Cardiovascular and metabolic syndrome impact on uristatin -- 10. Uristatin anti-inflammatory cellular signaling -- Part 5. Summary -- 11. Overview of progress in new markers for diabetes inflammation (Literatue Review).
    Also available: Print – 2015
  • 2013From: Springer
    Edmo Atique Gabriel, Sthefano Atique Gabriel, editors.
    Part I: General Topics. Neuroendocrine Response and Shock / Riad N. Younes, Fernando C. Abrão -- The Role of Lymphocytes in the Pathogenesis of Atherosclerosis: Focus on CD4+ T Cell Subsets / Ingrid E. Dumitriu -- Immunological Mechanisms of Inflammation / Nilo José Coêlho Duarte, Cyro Alves de Brito, Alberto José da Silva Duarte -- Part II: Carotid Diseases. Role of Lipoproteins in Carotid Arterial Disease / Efthymios D. Avgerinos, Christos D. Liapis -- Carotid Endarterectomy: Inflammatory Aspects / Sthefano Atique Gabriel, Edmo Atique Gabriel -- Endovascular Treatment of Carotid Disease: Inflammatory Aspects / Sthefano Atique Gabriel, Edmo Atique Gabriel -- Part III: Abdominal Aortic Aneurysm. Role of Matrix Metalloproteinases and Aortic Wall Degradation in Abdominal Aortic Aneurysms / George A. Antoniou, George S. Georgiadis -- Role of Haptoglobin in Abdominal Aortic Aneurysm / Valerio Napolioni -- Inflammatory Aortic Aneurysm / Guilherme Vieira Meirelles -- Endovascular Treatment of Abdominal Aortic Aneurysms: Current Approaches and New Devices / Armando de Carvalho Lobato, Robert Guimarães do Nascimento --
  • Lauren Marie Aquino Shluzas.
    Through an inductive, multi-case analysis, this dissertation examines how design and development practices, involving physicians and medical device developers, influence the clinical and financial outcomes of early stage medical device companies. This research was motivated by an interest in understanding the role of physicians in the device development process, specifically in terms of how physician interaction influences the acceptance or rejection of new medical products. An analytic framework for case-based research was first developed based on exploratory interviews with leaders in the medical device field. Retrospective case studies were then conducted on eight entrepreneurial firms (four rival pairs) in the areas of pulse oximetry, robotic surgery, cardiac bypass surgery, and minimally invasive spine surgery. Primary data sources included interviews with engineers, physicians, and business executives from each company; product development data including device prototypes, regulatory clearance data, and intellectual property (IP); and clinical and financial outcomes data. Following the period of data collection, within-case and across-case analyses were performed. The interview data for each case was coded for design and development practices involving physician-developer interaction, using NVivo qualitative analysis software (QSR International, Version 8). Development practices were analyzed using logic models to examine causal relationships between practices, and product and company outcomes. Design and development practices were further examined and supported using a combination of qualitative and quantitative evidence. Based on the multi-case analysis, this dissertation provides an overview of physician-developer interaction characteristics throughout each phase of the medical device development process. This includes a description of the roles and responsibilities of physicians engaged in development efforts, and their corresponding team affiliations. The research also illustrates four key factors that contributed to medical device adoption for the cases studied. First, the data highlight that designing products under variable use conditions (i.e. with variable patient populations and physicians of varying skill levels), enabled firms to optimize products for widespread clinical use and to increase the predictability of product outcomes. Second, the study shows that product adoption relied on maximizing benefits for multiple product stakeholders, while minimizing required changes in physician behavior. The data further illustrate that total benefit to product stakeholders was influenced to the greatest degree by benefits afforded to hospitals and physicians, assuming patient benefit was greater than or equal to the standard of care. Third, the study highlights that managing perceptions toward product use through performance data positively influenced product adoption to a greater degree than did market demand or regulatory clearance. Fourth, rival explanations for outcomes, involving limited physician interaction, indicate that competitive advantages were achieved through maintaining dominant financial and intellectual property positions. From these findings, the Insight-Value-Perception (iVP) Model for user-centered medical device design was constructed. The model links design and development practices to outcomes, from a combination of consumer-oriented, technical, and financial perspectives. This research provides theoretical contributions to product development and user-centered design literature, and provides practical contributions for developers in the medical device field. A contribution to product development literature is made through documenting the combined benefits of maximizing product value for stakeholders while managing data-driven perceptions toward product use. For the field of user-centered design, this research captures the benefits of designing medical technology with and for a broad consortium of product end-users, as opposed to industry leaders alone. The research also documents the importance of identifying the often-conflicting needs of product stakeholders, and then optimizing devices to satisfy the needs of those with the greatest influence over product use and adoption. For medical device practitioners, this dissertation provides design, regulatory, and product-testing strategies shown to increase technology adoption across the eight cases studied. From this thesis, the author proposes future studies to inform policies and strategies for device manufacturers and the FDA, and to advance knowledge in the fields of user-centered design and product development.
  • Shelly Beer.
    PrintStatus: Not Checked OutLane Catalog Record
  • 2007From: Springer
    edited by Anne Fagot-Largeault, Shahid Rahman and Juan Manuel Torres.
    Pt. 1. Genetics and the life sciences -- Pt. 2. Genetics and philosophy of science: the reductionism debate and beyond -- Pt. 3. Genetics and the ethical, legal and sociological debate.
  • 2017From: Springer
    Mieczyslaw Pokorski, editor.
    Respiratory infections constitute a major public health concern. The goal of this book is to share knowledge on the best advances in influenza and influenza-like viral infections, and new molecular-based diagnostic methods that discern the antigenic shift enabling viruses to constantly evolve and elude the host immune response. Co-infections, co-morbidities, persistently meager anti-flu vaccination coverage, and infection complications are dealt with. The chapters also further insight into such topics as the effects of sex hormones, and socioeconomic and anthropometric measures on respiratory and immune functions underlying the severity of asthma and respiratory allergy. Psychological functioning in respiratory disorders, taking into account quality of life, illness acceptance, and depressive symptoms is also reviewed as it is all too often underestimated by healthcare providers. The book is intended for clinicians, researchers, students, and all other actors in health-related issues.
  • Susan Kingsley Kent.
    Appearing in the midst of the First World War, the influenza virus of 1918-1919 blazed across the globe in a matter of months, leaving in its wake a death toll that would surpass that of the war itself. It appeared suddenly and with explosive impact, and defied all previous understandings of the disease: the illness struck quickly and without warning, felling people in their homes, at work, and in the streets, and unlike previous manifestations of the disease, which tended to take infants and the elderly, this strain primarily struck men and women in the prime of their lives. Especially virulent, it moved quickly through homes, military barracks, cities, and towns, first appearing in the American Midwest and quickly making its way to South America, Africa, Europe, Asia, and Australia. Doctors and other medical professionals were helpless to understand or treat it, and governments were unable to contain or manage it. By the time the virus died out in the fall of 1919, it had taken the lives of up to sixty million people. Like the war, the pandemic shook the foundations of individuals, families, and entire societies around the globe, and its impact would continue to be felt throughout the first half of the twentieth century.
  • 2014From: Springer
    Richard W. Compans, Michael B.A. Oldstone, editors.
    This two-volume work covers the molecular and cell biology, genetics and evolution of influenza viruses, the pathogenesis of infection, resultant host innate and adaptive immune response, prevention of infection through vaccination and approaches to the therapeutic control of infection.. Experts at the forefront of these areas provide critical assessments with regard to influenza virology, immunology, cell and molecular biology, and pathogenesis. Volume I provides overviews of the latest findings on molecular determinants of viral pathogenicity, virus entry and cell tropism, pandemic risk assessment, transmission and pathogenesis in animal species, viral evolution, ecology and antigenic variation, while Volume II focuses on the role of innate and adaptive immunity in pathogenesis, development of vaccines and antivirals.
  • 2015From: Springer
    Michael B.A. Oldstone, Richard W. Compans, editors.
    Part I. Innate immunity. The role of cytokine responses during influenza virus pathogenesis and potential therapeutic options / John R. Teijaro -- Innate immune sensing and response to influenza / Bali Pulendran and Mohan S. Maddur -- The NS1 protein: a multitasking virulence factor / Juan Ayllon and Adolfo García-Sastre -- Role of NK cells in influenza infection / Stacey Shultz-Cherry -- Host detection and the stealthy phenotype in influenza virus infection / Pradyot Dash and Paul G. Thomas -- Part II. Vaccines and adaptive immunity. Inactivated and adjuvanted influenza vaccines / Giuseppe Del Giudice and Rino Rappuoli -- Live attenuated influenza vaccine / Hong Jin and Kanta Subbarao -- Design of alternative live attenuated influenza virus vaccines / Courtney Finch, Weizhong Li and Daniel R. Perez -- Rapid production of synthetic influenza vaccines / Philip R. Dormitzer -- Influenza neuraminidase as a vaccine antigen / Maryna C. Eichelberger and Hongquan Wan -- Advances in universal influenza virus vaccine design and antibody mediated therapies based on conserved regions of the hemagglutinin / Florian Krammer, Peter Palese and John Steel -- Structural characterization of viral epitopes recognized by broadly cross-reactive antibodies / Peter S. Lee and Ian A. Wilson -- Skin immunization with influenza vaccines / Ioanna Skountzou and Richard W. Compans -- Mucosal immunization and adjuvants / Hideki Hasegawa, Elly van Reit and Hiroshi Kida -- B cell responses to influenza infection and vaccination / Christopher Chiu, Ali H. Ellebedy, Jens Wrammert and Rafi Ahmed -- Memory CD4 T cells in influenza / Kyra D. Zens and Donna L. Farber -- The effector T cell response to influenza infection / Matthew M. Hufford, Taeg S. Kim, Jie Sun and Thomas J. Braciale -- Part III. New antiviral discovery. Antiviral effects of inhibiting host gene expression / Ralph A. Tripp and S. Mark Tompkins -- Index.
  • 2014From: Future Med
    editor, John Oxford.
    Influenza surveillance / John S. Oxford -- Surveillance of influenza in swine and wildfowl / Ian H. Brown -- Global influenza surveillance: advances in technology / Mila C. González & Stephen S. Morse -- Ask the expert : origins of recent pandemics and lessons for surveillance / John S. Oxford -- Global seroepidemiology : value and limitations / Karen L. Laurie, Othmar G. Engelhardt, John Wood & Maria D. Van Kerkhove -- Influenza surveillance : interrupting transmission / Alan P. Zelicoff -- Pandemic influenza preparedness / Chloe Sellwood -- Multiple choice questions : answers.
  • 2008From: Springer
    Rino Rappuoli, Giuseppe Del Giudice, editors.
  • 2011From: Springer
    Rino Rappuoli, Giuseppe Del Giudice, editors.
    pt. 1. Evolution and epidemiology -- pt. 2. Immunity and vaccine strategies -- pt. 3. Economic and social implications.
  • 2012From: Springer Protocols
    edited by Yoshihiro Kawaoka, Gabriele Neumann.
    Influenza Viruses : an introduction / Yoshihiro Kawaoka and Gabriele Neumann -- Influenza virus isolation / Scott Krauss, David Walker, and Robert G. Webster -- Influenza virus titration, antigenic characterization, and serological methods for antibody detection / Alexander Klimov .. [et al.] -- Diagnosis of influenza virus / Kirsten St. George -- Solid-phase assays of receptor-binding specificity / Mikhail N. Matrosovich and Alexandra S. Gambaryan -- Chemiluminescent neuraminidase inhibition assay : a functional method for detection of influenza virus resistance to the neuraminidase inhibitors / Margaret Okomo-Adhiambo, Aeron C. Hurt, and Larisa V. Gubareva -- Fluorescence neuraminidase inhibition assay : a functional method for detection of influenza virus resistance to the neuraminidase inhibitors / Aeron C. Hurt, Margaret Okomo-Adhiambo, and Larisa V. Gubareva -- Animal models / Edwin J.B. Veldhuis Kroeze, Thijs Kuiken, and Albert D.M.E. Osterhaus -- Influenza virus surveillance, vaccine strain selection, and manufacture / Klaus Stöhr [and others] -- Genetic engineering of live attenuated influenza viruses / Hong Jin [and others] -- Influenza A virus molecular virology techniques / Bin Zhou and David E. Wentworth -- Reverse genetics of influenza viruses / Gabriele Neumann, Makoto Ozawa, and Yoshihiro Kawaoka -- Genetic analysis / Gavin J.D. Smith, Justin Bahl, and Dhanasekaran Vijaykrishna.
  • 2012From: Springer
    Mark von Itzstein, editor.
  • 2014From: Springer
    Eta S. Berner, editor.
    This book reviews and defines the current state of the art for informatics education in medicine and health care. This field has undergone considerable change as the field of informatics itself has evolved. Twenty years ago almost the only individuals involved in health care who had even heard the term "informatics" were those who identified themselves as medical or nursing informaticians. Today, we have a variety of subfields of informatics including not just medical and nursing informatics, but informatics applied to specific health professions (such as dental or pharmacy informatics), as well as biomedical informatics, bioinformatics and public health informatics. Informatics Education in Health Care addresses the broad range of informatics education programs available today. The Editor and very experienced internationally recognized informatics educators who have contributed to this work have made the tacit knowledge explicit and shared some of the lessons they have learned. This book therefore represents the key reference for all involved in the informatics education whether they be trainers or trainees.
  • 2012From: CRCnetBASE
    edited by George C. Kagadis, Steve G. Langer.
    Ontologies in the radiology department / Dirk Marwede -- Informatics constructs / Steve G. Langer -- Health level 7 imaging integration / Helmut König -- DICOM / Steven C. Horii -- Integrating the healthcare enterprise IHE / Steve G. Langer -- Operating systems / Christos Alexakos and George C. Kagadis -- Networks and networking / Christos Alexakos and George C. Kagadis -- Storage and image compression / Craig Morioka, Frank Meng, and Ioannis Sechopoulos -- Displays / Elizabeth A. Krupinski -- Digital X-ray acquisition technologies / John Yorkston and Randy Luhta -- Efficient database designing / John Drakos -- Web-delivered interactive applications / John Drakos -- Principles of three-dimensional imaging from cone-beam projection data / Frédéric Noo -- Multimodality imaging / Katia Passera, Anna Caroli, and Luca Antiga -- Computer-aided detection and diagnosis / Lioner T. Cheng, Daniel J. Blezek, and Brad J. Erickson -- Picture archiving and communication systems -- Brent K. Stewart -- Hospital information systems, radiology information systems, and electronic medical records / Herman Oosterwijk -- Procurement / Boris Zavalkovskiy -- Operational issues / Shawn Kinzel ... [et al.] -- Teleradiology / Dimitris Karnabatidis and Konstantinos Katsanos -- Ethics in the radiology department / William R. Hendee -- Imaging informatics beyond radiology / Konstantinos Katsanos ... [et al.] -- Informatics in radiation oncology / George Starkschall and Peter Balter.
  • 2014From: CRCnetBASE
    edited by George Starkschall, R. Alfredo C. Siochi.
    "A complete overview of the subject, this book discusses the role of information in the process of radiation oncology, acquisition, communication, and display of data; infrastructure requirements; and the use of data in clinical evaluation and research. It describes essential informatics tools, including various imaging techniques and image management systems, treatment planning systems, radiation oncology management systems, and the electronic medical record. Expert contributors explain how to obtain imaging and other diagnostic information as well as treatment prescriptions, treatment setup and delivery data, and outcome reviews"--Provided by publisher.
  • 2008From: Springer
    edited by Maristella Agosti.
  • 2011From: CRCnetBASE
    edited by Stephan Jones and Frank M. Groom.
    Ch. 1. Healthcare systems : Introduction / Frank M. Groom -- Ch. 2. Technology as a catalyst for health enhancement / Jane Ellery and Peter J. Ellery -- Ch. 3. Health information exchange / Dave Yoder -- Ch. 4. Universal data standards / Colleen Willis -- Ch. 5. Healthcare information exchange / Kent Supancik -- Ch. 6. Health information technology in the United States : achieving legal and regulatory results that enhance innovation and adoption / Stuart N. Brotman, Gabriel G. Brotman and Jennifer E. Paul -- Ch. 7. Healthcare regulations, privacy, security, and information age considerations / Sydney Morris -- Ch. 8. Usability : patient-physician interactions and the electronic medical record / Carolyn K. Shue and Laura L.S. O'Hara -- Ch. 9. Remembering human factors when implementing technology use : a case study in home healthcare usability / Lori A. Byers -- Ch. 10. Security and privacy : impacts of evolving technologies and legislation / Robert Faix, Chad Cagnolatti, and David Flynn -- Ch. 11. New facility planning : a healthcare focus / Todd Hollowell and Carl Fleming -- Ch. 12. Developing innovative health information for youth : communication theory for practical emerging media applications / Lou Ann Stroup, Chelsey Sigler, and Jay E. Gillette -- Ch. 13. Re-envisioning the website as a member-focused portal : a case study on usability and technology for transforming healthcare communication / Jared B. Linder -- Appendix: Glossary of health care terms from IBM.
  • 2008From: Springer
    by Giuseppe Primiero.

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