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  • Glycosylation is a common and extremely important modification in biological molecules, particularly of proteins. HIV Glycans in Infection and Immunity provides an overview of the roles of glycans in the transmission/infection, antigenicity, and immunogenicity of HIV and the HIV envelope glycoprotein. It explores recent advances in the understanding of the impact of HIV glycans in infection and their promise for immunological and therapeutic intervention. Novel collaborations between glycobiologists and immunologists in recent years have led to key advances in the understanding of HIV glycans. These cross-disciplinary endeavors, their achievements and their impact on the field are all addressed, herein.-- Source other than Library of Congress.
  • Preface -- Host restriction of HIV-1 by APOBEC3 and viral evasion through Vif -- Interactions of viral protein U (Vpu) with cellular factors -- TRIM5alpha -- Human immunodeficiency virus type-1 Gag and host vesicular trafficking pathways -- The roles of tetraspanins in HIV-1 replication -- Imaging of HIV/host protein interactions -- Virological and cellular roles of the transcriptional coactivator LEDGF/p75 -- Implications of Nef: host cell interactions in viral persistence and progression to AIDS -- Vpr and its interactions with cellular proteins.
  • HIV prevention 2013
    Future Med
    HIV prevention / Marie-Louise Newell & Frank Tanser -- Diagnosis and promotion of serostatus awareness in sub-Saharan Africa / Ruanne V. Barnabas, Heidi van Rooyen & Connie Celum -- Ask the experts : HIV vertical transmission prevention / Marie-Louise Newell & Claire Thorne -- The ART of pre- and post-exposure prophylaxis / Kevin Brian Rebe & James McIntyre -- Microbicides for HIV prevention : theory and future prospects / Gita Ramjee -- HIV prevention and men: general population and vulnerable subgroups / John Imrie, Geoff Jobson, Jerome Galea & Glenn de Swardt -- Implementation of HIV treatment-as-prevention : resources and behaviors / Till Bärnighausen & François Dabis -- Prevention of sexual transmission of HIV in adolescents / Audrey Pettifor, Molly Rosenberg & Sinead Delany-Moretlwe -- Mathematical modeling of HIV elimination strategies / Jan A.C. Hontelez & Leigh F. Johnson -- Multiple choice questions : answers.
  • Current and future trends: implications for HIV preventions / Vikrant V. Sahasrabuddhe and Sten H. Vermund -- Understanding the biology of HIV-1 transmission: the foundation for prevention / Deborah J. Anderson -- HIV vaccines / Robert E. Geise and Ann Duerr -- Microbicides / Ian McGowan -- Using antiretrovirals to prevent HIV transmission / Cynthia L. Gay, Angela D. Kashuba and Myron S. Cohen -- Male circumcision and HIV prevention / Ronald Gray, David Serwadda, Godfrey Kigozi and Maria J. Wawer -- Payoff from AIDS behavioral prevention research / Willo Pequegnat and Ellen Stover -- Individual interventions / Matthew J. Mimiaga ... [et al.] -- Couples' voluntary counseling and testing / Kathy Hageman, Amanda Tichacek and Susan Allen -- Updating HIV prevention with gay men: current challenges and opportunities to advance health among gay men / Ron Stall, Amy Herrick, Thomas E. Guadamuz and Mark S. Friedman -- Reducing sexual risk behavior among men and women with HIV infection / Jean L. Richardson and Tracey E. Wilson -- Injection drug use and HIV: past and future consideration for HIV prevention and interventions / Crystal M. Fuller, Chandra Ford and Abby Rudolph -- HIV risk and prevention for non-injection substance users / Lydia N. Drumright and Grant N. Colfax -- Preventing HIV among sex workers / Bea Vuylsteke, Anjana Das, Gina Dallabetta and Marie Laga -- Interventions with youth in high-prevalence areas / Quarraisha Abdool Karim, Anna Meyer-Weitz and Abigail Harrison -- Interventions with incarcerated persons / Ank Nijhawan, Nickolas Zaller, David Cohen and Josiah D. Rich -- Preventing mother-to-child transmission of HIV / James A. McIntyre and Glenda E. Gray -- Harm reduction, human rights and public health / Christ Beyrer, Susan G. Sherman and Stefan Baral -- HIV testing and counseling / Julie A. Denison, Donna L. Higgins and Michael D. Sweat -- Structural interventions in societal contexts / Suniti Solomon and Kartik K. Venkatesh -- Evaluating HIV/AIDS programs in the US and developing countries / Jane T. Bertrand, David R. Holtgrave and Amy Gregowski -- Adapting successful research studies in the public health arena: going from efficacy trials to effective public health interventions / Kevin A. Fenton, Richard J. Wolitski, Cynthia M. Lyles and Sevgi O. Aral.
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    v. 1. Viral mechanism -- v. 2. Clinical applications
  • 1. Prevention of HIV Infection in the Absence of a Vaccine -- 2. Study Report on Prevention of Mother to Child Transmission for HIV+ Pregnant Mothers in the Yunnan Province -- 3. Antiretroviral Treatment Compliance in the Wenlou Village of Henan Province: A Case Study in Rural China -- 4. HIV/AIDS Treatment and Control in India and the Millennium Development Goals -- 5. HIV Treatment Scale-Up in Africa: The Impact of Drug Resistance -- 6. A Practical Way to Improve Access to Essential Medicines Against Major Infectious Diseases -- 7. When will most AIDS patients in the world have access to effective antiretroviral therapy?
  • This book examines in detail the current treatment options for first-line, relapsed, and refractory Hodgkin lymphoma and the management appropriate in special clinical circumstances, including in the elderly, pregnant women, and those with lymphocyte-predominant disease. Careful attention is devoted to the emerging individually tailored treatment strategies that are especially appealing given their potential to reduce early and late treatment side effects in this generally young patient population. In addition, clear guidance is provided on the management of Hodgkin survivors. Other topics addressed include epidemiology, pathogenesis, the role of the microenvironment, initial clinical evaluation, imaging diagnosis, use of staging systems, and prognostic factors. The second edition of Hodgkin Lymphoma: A Comprehensive Overview has been revised and updated by the key opinion leaders to reflect recent progress in the field. It will be of great value to hematologists, oncologists, and all others with an interest in Hodgkin lymphoma. .
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    Anatomical terminology -- Tissues of the body -- Organs and organ systems -- General survey of the upper limb -- The shoulder -- The arm -- Forearm and hand : general survey -- Flexor forearms -- Extensor forearm -- Radioulnar and wrist movements -- The hand -- Movements of the digits -- The back -- General survey of the lower limb -- The bony pelvis, femur, and hip joint -- The thigh and knee -- Gluteal region and posterior thigh -- Movements of the thigh and leg -- The leg -- The foot -- The head and neck -- The thorax -- The abdomen and pelvis.
  • Holoscopy 2014
    Holoscopy is a new tomographic imaging modality that combines techniques of digital holography with Fourier-domain optical coherence tomography (FD-OCT). Dierck Hillmann gives a theoretical introduction to the mathematics and physics of holoscopy and develops an efficient numerical reconstruction procedure. Compared to FD-OCT, holoscopy provides unique advantages by enabling tomographic imaging without a limited depth of focus, but results in an increased numerical cost for reconstruction. In further chapters, the author introduces techniques for FD-OCT that are relevant to holoscopy as well. He demonstrates and compares numerical reconstruction methods for FD-OCT and shows how motion and dispersion artifacts in FD-OCT can be numerically compensated. Contents Theoretical Introduction to Optical Coherence Tomography and Digital Holography FD-OCT Signal Processing Using the Non-Equispaced Fast Fourier Transform Motion and Dispersion Correction in FD-OCT Holoscopy Target Groups Academics and practitioners in the fields of computer science, optical coherence tomography, digital holography, and medical imaging. The Author Dierck Hillmann received his doctoral degree in the group of Gereon Hüttmann at the Institute of Biomedical Optics in Lübeck and is currently working for a leading company in the fields of science and photonics. The Editor The series Aktuelle Forschung Medizintechnik is edited by Thorsten M. Buzug.
  • Malnutrition in the developing world: the lack of food scenario / D. Labadarios -- Are older people starving to death in a world of plenty? -- D.R. Thomas -- Physiological vs. pathological changes of nutritional status over life time -- M.J. Müller ... [et al.] -- Home enteral nutrition demographics and utilization in the United States / M.H. Delegge -- Home enteral nutrition epidemiology and legislation in Europe / A. Van Gossum -- When does malnutrition become a risk? / L. Genton ... [et al.] -- What are the goals of nutrition support? The example of home enteral nutrition / X. Hʹebuterne, S.M. Schneider, -- Oral protein and energy supplementation in older people: a systematic review of randomized trials / A.C. Milne, A. Avenell, J. Potter -- Efficacy of enteral and parenteral nutrition in cancer patients / F. Bozzetti, V. Bozzetti, -- Ethics and economics of nutritional support / A.L. Buchman -- Pathophysiology of weight loss in older persons / J.E. Morley -- Interaction between nutrition, intestinal flora and the gastrointestinal immune system / H. Lochs -- Psychoimmunology of nutrition / B. Lesourd -- How can we impact the immune system with pre- and probiotics? / E.J. Schiffrin, A. Donnet, S. Blum -- How can we modulate cytokine production and action? / L. Cynober -- How can we improve functional outcomes? / M. Elia.
  • A kinetic model for peritoneal dialysis and its application for complementary dialysis therapy / Yamashita, A.C. -- How automated peritoneal dialysis is applied and maintained in Japan / Nakamoto, H. -- Introduction and maintenance program for PD based on PD guidelines for Japan / Nakayama, M. -- Appropriate drug dosing in patients receiving peritoneal dialysis / Hirata, S., Kadowaki, D. -- Surgical and medical treatments of encapsulation peritoneal sclerosis / Kawanishi, H. -- Application of peritoneal dialysis in elderly patients by classifying the age into young-old, old, and oldest-old / Hiramatsu, M. ... [et al.] -- Maintenance of continuous ambulatory peritoneal dialysis in elderly patients / Ishida, M. -- Role of nurses in a continuous ambulatory peritoneal diagnosis outpatient clinic / Kimura, Y., Inoue, T., Suzuki, H. -- Combination therapy with hemodialysis and peritoneal dialysis / Suzuki, H. ... [et al.] -- Implementation of a cooperative program for peritoneal dialysis / Okada, K., Abe, M., Soma, M. -- Care for patients carrying out dialysis therapy at home / Imada, A. -- Perspectives on home hemodialysis in Japan / Maeda, K., Nakai, S. -- Current international status of home hemodialysis / Saito, A. ... [et al.] -- Future home hemodialysis : advantages of the NxStage System One / Takahashi, S. -- Introduction to home hemodialysis / Ogawa, H. -- Overnight home hemodialysis : eight patients and six years of experience in Sakairumi clinics / Tanaka, H. ... [et al.] -- Practice of home hemodialysis in dialysis clinic / Tomita, K. -- Perspective of home hemodialysis in Japan / Narikiyo, T., Nakamoto, M. -- Role of clinical engineers in home hemodialysis / Ohhashi, N. ... [et al.] -- Daily hemodialysis improves uremia-associated clinical parameters in the short term / Kojima, E. ... [et al.] -- Development of a nanotechnology-based dialysis device / Kanno, Y., Miki, N.
  • Introduction -- Background and objectives of HTA -- Introduction to the speciality of homeopathy - principles and definition -- Homeopathy: Research and Research Problems (preclinical and clinical) -- General problems with clinical trials in research -- HTA Homeopathy: Methods and Material -- International Utilisation of Complementary Medical Approaches -- CAM Conditions and Use in Switzerland -- Overview of Systematic Reviews on the Clinical Efficacy of Homeopathy -- Clinical Studies on the Effectiveness of Homeopathy for URTI/A (Upper Respiratory Tract Infections and Allergic Reactions) -- Safety of Homeopathic Use -- Cost-effectiveness of Homeopathy -- Full discussion of the HTA results -- Synopsis.
  • Human homeostasis refers to complex interactions to regulate and maintain the internal conditions of the organism under stable condition. In spite of the progress made on cell growth and division, the circuits that coordinate these processes and maintain the homeostatic balance between cell growth and cell death have not been clarified. Deregulation of homeostatic processes results in different forms of imbalances that can turn to diseases including hepatitis, cyrrhosis and tumor formation. Abnormal growth of tissues can lead to a broad spectrum of neoplastic diseases from tissue swelling, primary tumor formation, cancer and ultimately to secondary tumors known as metastases. Tumor formation is a complex process, that develops through many steps. The discussion of balance and its loss in cell growth, primary and secondary tumor formation necessitate basic information in chemistry (carcinogenesis), biochemistry (metabolism), physics (instrumentation), cell biology (compartments), anatomy, physiology, clinical experience (screening, medical imaging, therapy). The focus of this book has been placed on: a) balance of cell growth, b) tumor formation, c) development of cancer and metastasis, e) diagnosis and treatment of cancer. The steps of the lymphatic type of metastatic tumor spread are described. Due to the interdisciplinary nature, the book gives information for a wide audience including biology, biotechnology, molecular, ecology, medical, pharmacist, chemist students. Additional information is provided for biomedical, pharma, medical and life scientists, physicians and health care professionals.
  • Approaches to the analysis of faunal change during the East African Pliocene / A.K. Behrensmeyer, R. Bobe, and Z. Alemseged -- Environmental hypotheses of Pliocene human evolution / R. Potts -- African Pliocene and Pleistocene cercopithecid evolution and global climatic change / S.R. Frost -- Patterns of change in the Plio-Pleistocene carnivorans of eastern Africa : implications for hominin evolution / M.E. Lewis and L. Werdelin-- Stratigraphic variation in Suidae from the Shungura Formation and some coeval deposits / H.B.S. Cooke -- Patterns of abundance and diversity in late Cenozoic bovids from the Turkana and Hadar Basins, Kenya and Ethiopia / R. Bobe, A.K. Behrensmeyer, G.G. Eck, and J.M. Harris -- Comparability of fossil data and its significance for the interpretation of hominin environments : a case study in the lower Omo Valley, Ethiopia / Z. Alemseged, R. Bobe, and D. Geraads -- The effects of collection strategy and effort on faunal recovery : a case study of the American and French collections from the Shungura Formation, Ethiopia / G.G. Eck -- Serengeti micromammals and their implications for Olduvai paleoenvironments / D.N. Reed -- Taphonomy and paleoecological context of the upper Laetolil Beds (localities 8 and 9), Laetoli in northern Tanzania / C. Musiba, C. Magori, M. Stoller, T. Stein, S. Branting, M. Vogt, R. Tuttle, B. Hallgrímsson, S. Killindo, F. Mizambwa, F. Ndunguru, and A. Mabulla -- The paleoecology of the upper Laetolil Beds at Laetoli : a reconsideration of the large mammal evidence / D.F. Su and T. Harrison -- Fauna, taphonomy, and ecology of the Plio-Pleistocene Chiwondo Beds, northern Malawi / O. Sandrock, O. Kullmer, F. Schrenk, Y.M. Juwayeyi, and T.G. Bromage-- Investigating faunal evidence for hominin paleoecology in East Africa / A.K. Behrensmeyer, Z. Alemseged, and R. Bobe.
  • Excess of homocysteine, a product of the metabolism of the essential amino acid methionine, is associated with poor health, is linked to heart and brain diseases in general human populations, and accelerates mortality in heart disease patients. Neurological and cardiovascular abnormalities occur in patients with severe genetic hyperhomocysteinemia and lead to premature death due to vascular complications. Although it is considered a non-protein amino acid, studies over the past dozen years have discovered mechanisms by which homocysteine becomes a component of proteins. Homocysteine-containing proteins lose their normal biological function and become auto-immunogenic and pro-thrombotic. In this book, the author, a pioneer and a leading contributor to the field, describes up-to date studies of the biological chemistry of homocysteine-containing proteins, as well as pathological consequences and clinical implications of their formation. This is a comprehensive account of the broad range of basic science and medical implications of homocysteine-containing proteins for health and disease.
  • Ch. 1. Honey : an ethnomedicine / Yuva Bellik and Lad̐ Boukra ́-- ch. 2. Honey in Ayurvedic medicine / Surya Prakash and Ratna Rao -- ch. 3. Biochemistry and physicochemical properties of honey / Sevgi Kolayli ... [et al.] -- ch. 4. Healing properties of honey / Lad̐ Boukra ́-- ch. 5. Importance of botanical origin of honeys / Sad́ Aissat and Hama Benbarek -- ch. 6. Leptospermum (Manuka) honey : accepted natural medicine / Yasmina Sultanbawa -- ch. 7. Honey in burn and wound management / Lad̐ Boukra ́-- ch. 8. Honey for gastrointestinal disorders / Fatiha Abdellah and Leila Ait Abderrahim -- ch. 9. Honey for cardiovascular diseases / Tahira Farooqui and Akhlaq A. Farooqui -- ch. 10. Honey for diabetic ulcers / Hasan Ali Alzahrani -- ch. 11. Honey in pediatrics / Juraj Majtan -- ch. 12. Honey and cancer : a sustainable parallel relationship particularly for developing nations / Nor Hayati Othman -- ch. 13. Honey and bee products for animal health and wellness / Lad̐ Boukra ́-- ch. 14. Honey-based formulations and drug purposes / Sad́ Aissat ... [et al.] -- ch. 15. Modern methods of analysis applied to honey / Satyajit D. Sarker and Lutfun Nahar -- ch. 16. Mad honey : the reality / Abd¿lkadir Gunduz and Faik Ahmet Ayaz -- ch. 17. Honey as a nutrient / Md. Ibrahim Khalil and Nadia Alam -- ch. 18. Honey in the food industry / Yuva Bellik and Mokrane Iguerouada -- ch. 19. Culinary uses of honey / Oktay Yildiz, H¿seyin Sahin, and Sevgi Kolayli.
  • The Good, the bad, and the ugly : a story of two medications -- An Ethical framework -- The Pharmaceutical industry and the free market -- Patents, generic drugs, and academic science -- Research and profits -- Suppression of research data -- The Quality of pharmaceutical research -- The Drug rep: historical background -- The Drug rep today -- The Influence of drug reps: what the data show -- Continuing medical education -- Professional organizations and journal advertising -- The Industry and the consumer -- The FDA: from patent medicines to AIDS drugs -- The FDA and the industry, 1990-2004 -- Solutions: the management and divestment strategies -- Solutions requiring enhanced professionalism in medicine -- Solutions requiring regulatory reform.
  • 1. Introduction in clinical nanomedicine / Stergios Logothetidis -- 2. Nanomedicine combats atherosclerosis / Varvara Karagkiozaki -- 3. Nanomedicine advancements in cancer diagnosis and treatment / Eric Michael Bratsolias Brown -- 4. Nanomedicine and blood diseases / Emmanouil Nikolousis -- 5. Nanomedicine and orthopaedics / Fares E. Sayegh -- 6. Nanopharmaceutics : structural design of cationic gemini surfactant-phospholipid-DNA nanoparticles for gene delivery / Marianna Foldvari -- 7. Nanomedicine and embryology : causative embryotoxic agents which can pass the placenta barrier and induce birth defects / Elpida-Niki Emmanouil-Nikoloussi -- 8. Nanomedicine and HIV/AIDS / Enikő R. Tőke and Julianna Lisziewicz -- 9. Nanoscaffolds and other nano-architectures for tissue engineering-related applications / Paraskevi Kavatzikidou and Stergios Logothetidis -- 10. Biocompatible 2D and 3D polymeric scaffolds for medical devices / Masaru Tanaka -- 11. Regenerative dentistry : stem cells meet nanotechnology / Lucía Jiménez-Rojo, Zoraide Granchi, Anna Woloszyk, Anna Filatova, Pierfrancesco Pagella, and Thimios A. Mitsiadis -- 12. Toxicity and genotoxicity of metal and metal oxide nanomaterials : a general introduction / Mercedes Rey, David Sanz, and Sergio E. Moya -- 13. Analogies in the adverse immune effects of wear particles, environmental particles, and medicinal nanoparticles / Eleonore Fröhlich.
  • Gene transfer: who benefits? / L. Olendzenski and J.P. Gogarten -- Defining the mobilome / J.L. Siefert -- The interplay of homologous recombination and horizontal gene transfer in bacterial speciation / J.G. Lawrence and A.C. Retchless -- Epistemological impacts of horizontal gene transfer on classification in microbiology / E. Bapteste and Y. Boucher -- Persistence mechanisms of conjugative plasmids / M.I. Bahl, L.H. Hansen and S.J. Sorensen -- The integron/gene cassette system: an active player in bacterial adaptation / M. Labbate, R.J. Case and H.W. Stokes -- Ancient gene transfer as a tool in phylogenetic reconstruction / J. Huang and J.P. Gogarten -- The tree of life viewed through the contents of genomes / C.H. House -- Horizontal gene transfer and the evolution of methanogenic pathways / G. Fournier -- Genome acquisition in horizontal gene transfer: symbiogenesis and macromolecular sequence analysis / L. Margulis -- Detection and quantitative assessment of horizontal gene transfer / O. Zhaxybayeva -- Composition-based methods to identify horizontal gene transfer / D. Cortez ... [et al.] -- Testing phylogenetic methods to identify horizontal gene transfer / M. Poptsova -- Untangling hybrid phylogenetic signals: horizontal gene transfer and artifacts of phylogenetic reconstruction / R.G. Beiko and M.A. Ragan -- Construction and use of flow cytometry optimized plasmid-sensor strains / M.I. Bahl ... [et al.] -- Experimental evolution of an essential Bacillus gene in an E. coli host / M. Larios-Sanz and M. Travisano -- Mass action models describing extant horizontal transfer of plasmids: inferences and parameter sensitivities / B.F. Smets and L. Lardon -- Interdomain transfers of sugar transporters overcome barriers to gene expression / K.M. Noll and K. Thirangoon -- The role of horizontal gene transfer in photosynthesis, oxygen production, and oxygen tolerance / J. Raymond -- Horizontal gene transfer in cyanobacterial signature genes / S. Yerrapragada, J.L. Siefert and G.E. Fox -- Population genomics and the bacterial species concept / M.A. Riley and M. Lizotte-Waniewski -- A critique of prokaryotic species concepts / R.T. Papke -- What antimicrobial resistance has taught us about horizontal gene transfer / M. Barlow -- Potential for horizontal gene transfer in microbial communities of the terrestrial subsurface / J.M. Coombs -- Horizontal gene transfer and mobile genetic elements in marine systems / P.A. Sobecky and T.H. Hazen -- Horizontal gene transfer in metal and radionuclide contaminated soils / P.A. Sobecky and J.M. Coombs -- Horizontal gene transfer between microbial eukaryotes / J.O. Andersson -- Horizontal gene transfer in eukaryotic parasites: a case study of Entamoeba histolytica and Trichomonas vaginalis / U.C. Alsmark ... [et al.] -- Role of horizontal gene transfer in the evolution of photosynthetic eukaryotes and their plastids / P.J. Keeling -- Role of horizontal gene transfer in the evolution of plant parasitism among nematodes / M. Mitreva, G. Smant and J. Helder.
  • Pt. 1. Genetic disorders of steroids : speakers -- pt. 2. Prenatal diagnosis of congenital adrenal hyperplasia : speakers -- pt. 3. Treatment of congenital adrenal hyperplasia : speakers -- pt. 4. Receptor defects : speakers -- pt. 5. Psychological aspects of intersex : speakers -- pt. 6. Embryology of sex differentiation : speakers -- pt. 7. Disorders of sex differentiation : speakers -- pt. 8. Hormonal hypertension : speakers -- pt. 9. Skeletal biology : speakers -- pt. 10. Posters.
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  • Immunoassay techniques / Michael J. Wheeler -- High-performance liquid chromatography for hormone assay / John W. Honour -- Gas chromatography-mass spectrometry / John W. Honour -- An introduction to PCR techniques / Gill Rumsby -- Methods for the investigation of thyroid function / Christine R. Squire -- Assays for LH, FSH, and prolactin / Michael J. Wheeler -- Adrenocorticotropic hormone and related peptides / Les A. Perry -- Measurement of glucocorticoids in biological fluids / Geoff Holder -- Urinary steroid profiling / Norman F. Taylor -- Measurement of aldosterone in blood / Marion L. Cawood -- Measurement of plasma renin activity / Marion L. Cawood -- Measurement of androgens / Michael J. Wheeler -- Measurement of gut hormones in plasma / Shahred Taheri, Mohammed Ghatei, and Steve Bloom -- Measurement of melatonin and 6-sulphatoxymelatonin / Benita Middleton.
  • Thyroid hormone transporters and resistance / T.J. Visser -- Genetics and epigenetics of parathyroid hormone resistance / M. Bastepe -- Gonadotropin resistance / A.C. Latronico, I.J.P. Arnhold -- Clinical and molecular aspects of androgen insensitivity / O. Hiort -- Exploring the molecular mechanisms of glucocorticoid receptor action from sensitivity to resistance / S. Ramamoorthy, J.A. Cidlowski -- ACTH resistance : genes and mechanisms / E. Meimaridou ... [et al.] -- Primary generalized familial and sporadic glucocorticoid resistance (chrousos syndrome) and hypersensitivity / E. Charmandari, T. Kino, G.P. Chrousos -- Pseudohypoaldosteronism / F.G. Riepe -- New aspects of the physiology of the GH-IGF-1 axis / A. Vottero, C. Guzzetti, S. Loche -- Molecular and clinical aspects of GHRH receptor mutations / V. Corazzini, R. Salvatori -- Current issues on molecular diagnosis of GH signaling defects / E. Feigerlova ... [et al.] -- Molecular IGF-1 and IGF-1 receptor defects : from genetics to clinical management / M.J.E. Walenkamp, M. Losekoot, J.M. Wit -- Phenotypes, investigation, and treatment of primary IGF-1 deficiency / M.O. Savage -- Human congenital perilipin deficiency and insulin resistance / K. Kozusko, S. Patel, D.B. Savage.
  • Hormone Therapy: A Clinical Handbook provides a comprehensive overview on hormone replacement therapy, with a range of key features that differentiate it from other titles on the topic. This concise, handy title presents an interdisciplinary approach to the subject, acknowledging that sex hormones affect more than reproductive organs and hot flushes for a deeper understanding of how hormones function. The authors provide a breadth and depth of practical prescribing experience, including many helpful tables and algorithms as well as directions for prescribing hormone therapy in the most effective way.
  • Physical activity exerts an important influence on the endocrine system, modulating synthesis and secretion of several hormones. Almost every organ and system in the body is affected by physical activity and exercise, mainly through the endocrine and neuroendocrine system. Mode, intensity, and duration of the exercise bout, age, gender and fitness level of the individual as well as environmental and psychological factors may affect the endocrine response to physical activity. On the other hand, several hormones are able to influence physical performance and body composition. Thus, a bi-univocal interrelationship between exercise and hormones exists. In this book new developments on metabolic and endocrine response to exercise are revised and introduce the 'hot topic' of hormonal doping in sports. In the past decades, hormone abuse has become a widespread habit among professional and - most of all and more frequently - recreational athletes. A substantial part of this volume is devoted to the effects of exogenous hormones on performance. Anabolic steroids, growth hormone and erythropoietin properties, use and misuse in sports are widely described. Specific methods to detect hormone abuse are presented and discussed. The contributors to this volume are well-known experts and dedicated researchers in the fields of sports medicine and endocrinology, endocrine physiology, pharmacology, and doping detection. The purpose of this volume is to provide all professionals involved in sports medicine and endocrinology a state-of-the-art overview of the complex interactions between physical activity and the endocrine system and to focus on hormone abuse in sports at competitive and recreational level highlighting its negative consequences for long-term health.
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    Foreword / N.P. Napalkov -- Landmarks in the life of Vladimir Dilman as a scientist, teacher, human being / E.V. Tsyrlina -- Vladimir Dilman: pioneer in the integrative understanding of pathological aging processes / C.E. Finch -- Modern concepts of hormonal carcinogenesis: mechanisms predisposing factors, consequences / L.M. Berstein -- Cell proliferation and cancer therapy / M.V. Blagosklonny -- Neuroendocrine modulation of menopause: evolution of our thinking / P.M. Wise, L.M. Gerhold and A.B. Cashion -- Carcinogenic aging / V.N. Anisimov -- Antidepressant effect of N-acetylserotonin in relation to aging, hypertension and cancer / G.F. Oxenkrug -- Adipocytokines, insulin resistance and main non-communicable diseases / Y. Matsuzawa -- Metabolic immunodepression revisited / A.G. Golubev and S.Yu. Revskoy -- Hormone replacement therapy and breast cancer in postmenopausal women / T. Gathani and V. Beral -- Our endogenous "pineal clock" and cancer. Cancer and non-cancer. Strategies for early detection, prevention and cure of neoplastic processes / W. Pierpaoli -- Glucocorticoid action networks and systemic complex diseases / G.P. Chrousos and T. Kino -- The twin epidemic--diabetes and obesity: the health challenge of the 21st century / P. Zimmet and D. Chisholm -- Selected bibliography of Vladimir Dilman.
  • Section I. Applied epidemiology and biostatistics in healthcare epidemiology and infection control -- Section II. Healthcare quality improvement -- Section III. Informatics in healthcare epidemiology -- Section IV. Epidemiology and prevention of healthcare-associated infections of organ systems -- Section V. Epidemiology and prevention of healthcare-associated infections caused by specific pathogens -- Section VI. Epidemiology and prevention of healthcare-associated infections in pediatric patients -- Section VII. Epidemiology and prevention of healthcare-associated infections in special patient populations -- Section VIII. Epidemiology and prevention of healthcare-associated infections related to diagnostic and therapeutic procedures -- Section IX. Prevention of healthcare-associated infections related to the hospital environment -- Section X. Epidemiology and prevention of healthcare-associated infections in healthcare workers -- Section XI. Disinfection and sterilization -- Section XII. Prevention of infectsions acquired by patients in healthcare facilities related to design, construction, renovation, demolition and ventilation systems -- Section XIII. Antimicrobial agents in healthcare epidemiology and infection control -- Section XIV. Literature in healthcare epidemiology and infection control -- Section XV. Organization and implementation of infection control programs -- Section XVI. Healthcare epidemiology and infection control in special settings for healthcare delivery -- Section XVII. Bioterrorism.
  • Introduction -- Hospital Discharges -- Hospital Procedures -- Hospital Discharges Involving Injury and Poisoning -- Definitions -- Technical Notes.
  • Section 1. Isolated pediatric eye disorders -- Section 2. Ocular manifestations of systemic disease.
  • Musculoskeletal history and physical examination -- Thinking like a rheumatologist -- Immunology for the primary care physician -- Rheumatologic laboratory tests -- Immunogenetic aspects of rheumatic diseases -- Bone, connective tissue, joint and vascular biology and pathology -- Diagnostic imaging techniques -- Arthrocentesis, intra-articular injection, and synovial fluid analysis -- Measuring clinical outcomes in rheumatic disease -- Ethical and legal considerations -- Patient education -- Psychosocial aspects of the rheumatic diseases -- Acute management of musculoskeletal and autoimmune diseases -- Monarthritis/polyarthritis: differential diagnosis -- Muscle pain and weakness -- Rash and arthritis -- Raynaud's phenomenon -- Autoimmune and inflammatory ophthalmic diseases -- Neck pain -- Low back pain -- Shoulder pain -- Elbow pain -- Hip pain -- Knee pain -- Ankle and foot pain -- Sports injuries -- The female athlete -- Bursitis and tendinitis -- Rheumatoid arthritis -- Systemic lupus erythematosus -- Antiphospholipid syndrome -- Dermatomyositis, polymyositis, and inclusion body myositis -- Sjögren's syndrome -- Systemic sclerosis and related syndromes -- Polymyalgia rheumatica and giant cell arteritis -- Childhood rheumatic diseases -- The vasculitides -- Pregnancy and connective tissue disorders -- Ankylosing spondylitis -- Arthritis associated with ulcerative colitis and Crohn's disease -- Psoriatic arthritis -- Reactive arthritis -- Gout -- Pseudogout (calcium pyrophosphate dihydrate crystal arthropathy) -- Human immunodeficiency virus -- Infectious arthritis -- Lyme disease -- Osteomyelitis -- Rheumatic fever -- Whipple's disease -- Osteoarthritis -- Osteonecrosis -- Osteoporosis -- Paget's disease of bone -- Endocrine arthropathies -- Fibromyalgia and chronic pain -- Paraneoplastic musculoskeletal syndromes and hypertrophic osteoarthropathy -- Miscellaneous diseases with rheumatic manifestations -- Prosthetic joint replacement -- Perioperative care of the patient with rheumatic disease -- Physical therapy -- Occupational therapy: therapist's management of rheumatologic disorders of the hand.
  • This gorgeous, full-color atlas and case-book presents more than sixty cases with over one hundred associated, super high-quality clinical images that a physician needs to be able to rapidly recognize and know for accurate, expedient diagnosis and treatment. The images are presented with the patient & rsquo;s brief medical history, followed by the diagnosis, brief discussion of the diagnosis, and the patient & rsquo;s clinical course and treatment. These miniature case studies encompass photos and descriptions of patients, supporting physical findings, X-rays, CT scans, electrocardiograms, blood s.
  • The art of medicine becomes science when supported by evidence. The recommended practices of infection prevention are based on scientific and epidemiologic evidence. However,most health care professionals see them as mandates and fail to incorporate them into their routine patient care activities. Thecore goal of this publication is to link the practices to theprinciples they are based on. The expectation is that understanding ofthe principles willchange thepractices from mandates to "should do" in the minds of health care professionals. This will lead to improvement inhealth care by preventing unintended harm to patients, co-workers and the communities at large. At the same time, the text provides a comprehensive, thorough and up to date information on all aspects of infection prevention in a reader-friendly manner and therefore, will serve as a valuable reference.
  • General issues -- Critical care medicine -- Medical consultation -- Cardiology -- Vascular medicine -- Pulmonary -- Infectious diseases -- Hiv disease -- Gastroenterology -- Hematology - oncology -- Renal -- Endocrinology -- Rheumatology -- Neurology and psychology -- Toxicology and allergy.
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    sect. 1. The development of sound personnel practices in hospitals -- sect. 2. Conference techniques.
  • Hospital bedside listening as true hospitality to the sick -- Interpersonal conversation -- Pastoral conversations with hospital patients -- From patient's story to homily -- The preaching evaluation -- Homilies -- Conclusion.
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  • Hospital-acquired pneumonia / Ilias I. Siempos -- Risk factors / Simone Gattarello, Despoina Koulenti & Jordi Rello -- Etiology and pathophysiology of hospital-acquired pneumonia / Ian Weir, Luciano Silvestri & Hendrick K.F. van Saene -- Symptoms, diagnosis and prognosis / Despoina Koulenti & Alexis Tabah -- Ventilator-associated pneumonia / Jana Hudcova & Donald E. Craven -- Prevention as a key measure to improve healthcare quality and patient safety / Dominique M. Vandijck, Stijn I. Blot, Sonia O. Labeau & Dirk P. Vogelaers -- Guidelines for the management of hospital-acquired pneumonia / Adamantia Liapikou -- Index.
  • Streptococci are Gram-positive bacteria that cause a wide spectrum of diseases, such as pharyngitis, necrotizing fasciitis and streptococcal toxic shock syndrome, as well as rheumatic fever and rheumatic heart disease as sequelae. Antibiotics alone have not been able to control the disease and in spite of many efforts an effective vaccine is not yet available. A prerequisite for novel and successful strategies for combating these bacteria is a complete understanding of the highly complex pathogenic mechanisms involved, which are analyzed in this volume. In ten chapters, prominent authors cover various aspects including streptococcal diseases and global burden, epidemiology, adaptation and transmission, and molecular mechanisms of different diseases, as well as sequelae, vaccine development and clinical management. This book will serve as a valuable reference work for scientists, students, clinicians and public health workers and provide new approaches to meeting the challenge of streptococcal diseases.
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    "As she traces the medicalization of menopause over the past hundred years, historian Judith Houck challenges some widely held assumptions. Physicians hardly foisted hormones on reluctant female patients; rather, physicians themselves were often reluctant to claim menopause as a medical problem and resisted the widespread use of hormone therapy for what was, after all, a normal transition in a woman's lifespan. Houck argues that the medical and popular understandings of menopause at any given time depended on both pharmacological options and cultural ideas and anxieties of the moment. As women delayed marriage and motherhood and entered the workforce in greater numbers, the medical understanding, cultural meaning, and experience of menopause changed. By examining the history of menopause over the course of the twentieth century, Houck shows how the experience and representation of menopause has been profoundly influenced by biomedical developments and by changing roles for women and the changing definition of womanhood."--BOOK JACKET.
  • Neural membranes: a Pandora's box of lipid mediators -- Interplay among glycerophospholipid, sphingolipid, and cholesterol-derived lipid mediators in brain: a matter of life and death -- Janus face of phospholipase A₂: role of phospholipase A₂ in neural cell survival and death -- Glycerophospholipid metabolism in the nucleus: cross talk among phospholipase A₂, phospholipase C and phospholipase D -- Ether glycerophospholipids: the workhorse lipids of neural membranes -- Excitotoxicity-mediated neurochemical changes in neurological disorders -- Recent developments on kainate-mediated neurotoxicity and their association with generation of lipid mediators -- Beneficial effects of docosahexaenoic acid on health of the human brain -- Effects of statins and n-3 fatty acids on heart and brain tissues: the clash of the titans -- Apoptosis and necrosis in brain: contribution of glycerophospholipid, sphingolipid, and cholesterol-derived lipid mediators -- Perspective and directions for future developments on glycerophospholipid-, sphingolipid-, and cholesterol-derived lipid mediators.
  • An estimated 86.0 percent of American households were food secure throughout the entire year in 2014, meaning that they had access at all times to enough food for an active, healthy life for all household members. The remaining households (14.0 percent) were food insecure at least some time during the year, including 5.6 percent with very low food security, meaning that the food intake of one or more household members was reduced and their eating patterns were disrupted at times during the year because the household lacked money and other resources for food. The change in food insecurity overall from the prior year (from 14.3 percent in 2013) was not statistically significant. The cumulative decline in food insecurity from 2011 (14.9 percent) to 2014 (14.0 percent) was statistically significant. The prevalence rate of very low food security was essentially unchanged from 5.6 percent in 2013 and 5.7 percent in 2011 and 2012. Children and adults were food insecure in 9.4 percent of households with children in 2014, essentially unchanged from 9.9 percent in 2013 and 10.0 percent in 2011 and 2012. In 2014, the typical food-secure household spent 26 percent more on food than the typical food-insecure household of the same size and household composition. Sixty-one percent of all food-insecure households participated in one or more of the three largest Federal food and nutrition assistance programs during the month prior to the 2014 survey.
  • Household Use of Solid Fuels -- 1. Exposure data -- 2. Studies of cancer in humans -- 3. Studies of cancer in experimental animals -- 4. Mechanistic and other relevant data -- 5. Summary of data reported -- 6. Evaluation and rationale -- -- High-temperature Frying -- 1. Exposure data -- 2. Studies of cancer in humans -- 3. Studies of cancer in experimental animals -- 4. Mechanistic and other relevant data -- 5. Summary of data reported -- 6. Evaluation and rationale
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  • Income is a driving force behind the striking health disparities that many minorities experience. In fact, although blacks and Hispanics have higher rates of disease than non-Hispanic whites, these differences are "dwarfed by the disparities identified between high- and low-income populations within each racial/ethnic group." That is, higher-income blacks, Hispanics, and Native Americans have better health than members of their groups with less income, and this income gradient appears to be more strongly tied to health than their race or ethnicity.
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    Introduction -- Flesh-and-blood decision making -- Lessons from the heart -- Spinning plates -- Gatekeepers -- A new mother's challenge -- The uncertainty of the expert -- Surgery and satisfaction -- The eye of the beholder -- Marketing, money, and medical decisions -- In service of the soul -- Epilogue : a patient's questions.
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    "In this provocative book, Edward Shorter describes how in the 19th century patients with anxiety, fatigue and unable to sleep and obsess about the whole thing were considered "nervous," and when they lost control it was a "nervous breakdown." Then psychiatry turned its back on the whole concept of nerves, and--first under the influence of Freud's psychoanalysis and then the influence of the pharmaceutical industry--the diagnosis of depression took center stage. The result has been a scientific disaster, leading to the misdiagnosis and inappropriate treatment (with "antidepressants") of millions of patients. And with the new 5th edition of the Diagnostic and Statistical Manual (DSM-5), the trend of inappropriate treatment is sure to continue. Urging that the diagnosis of depression be re-thought, this book turns a dramatic page in the understanding of psychiatric symptoms that are as common as the common cold. A gripping historical argument on psychiatric diagnosis and its flawed heritage and future."--Jacket.
  • Hormonal control of metabolism by the hypothalamus-autonomic nervous system-liver axis / Kalsbeek, A.; Bruinstroop, E.; Yi, C.-X.; Klieverik, L.; Liu, J.; Fliers, E. -- The blood-brain barrier as a regulator of the gut-brain axis / Schaeffer, M.; Hodson, D.J.; Mollard, P. -- The brain modulates insulin sensitivity in multiple tissues / Parlevliet, E.T.; Coomans, C.P.; Rensen, P.C.N.; Romijn, J.A. -- The important role of sleep in metabolism / Copinschi, G.; Leproult, R. ; Spiegel, K. -- Metabolic interplay between gut bacteria and their host / Duca, F.; Giard, P.; Covasa, M.; Lepage, P. -- The brain-stomach connection / Folgueira, C.; Seoane, L.M.; Casanueva, F.F. -- Prader-Willi syndrome as a model of human hyperphagia / Tauber, M.; Diene, G.; Mimoun, E.; Aabal-Berthoumieu, S.; Mantoulan, C.; Molinas, C.; Muscatelli, F.; Salles, J.P. -- Interactions between the gut, the brain and brown adipose tissue function / van den Beukel, J.C.; Grefhorst, A. -- Gut sweet taste receptors and their role in metabolism / Meyer-Gerspach, A.C.; Wilnerhanssen, B.; Beglinger, C. -- What is the role of metabolic hormones in taste buds of the tongue / Cai, H.; Maudsley, S.; Martin, B. -- Protein PYY and its role in metabolism / Price, S.L.; Bloom, S.R. -- Nutropioids regulate the gut-brain circuit controlling food intake / Mithieux, G. -- Should we consider des-acyl ghrelin as a separate hormone and if so, what does it do? / Delhanty, P.J.D.; Neggers, S.J.; van der Lely, A.J. -- Obestatin : is it really doing something? / Trovato, L.; Gallo, D.; Settanni, F.; Gesmundo, I.; Ghigo, E.; Granata, R.
  • "Helminth infections are common, cause considerable pathology, and alter a host's immune profile. This can have important consequences not only on the host's ability to control a helminth infection, but also on their ability to control unrelated infections. In endemic areas, understanding how helminth infection influences the outcome of common infectious diseases and changes the efficacy of childhood vaccination programs is an important public health question. This book reviews how host immunity to helminths alters our ability to respond to the major pathogens that exist in helminth endemic regions. Current understanding of how helminths alter important but relatively neglected contributors to the host's anti-helminth immune responses are addressed, namely host antibody responses and how maternal infection may alter a child's immune development. These are discussed in relation to the control of helminth infection and unrelated infections. Also covered are how helminth infections alter the host's ability to control TB, HIV and malarial infections along with neglected bacterial infections, such as cholera, and how endemic helminth infections are likely to alter our ability to respond to life-saving vaccination strategies"--Publisher's description.
  • Recognition of pathogens: toll-like receptors / Satoshi Uematsu, Shizuo Akira -- Strategies of natural killer (NK) cell recognition and their roles in tumor immunosurveillance / C. Andrew Stewart, Eric Vivier -- Recent progress on paired immunoglobulin-like receptors / Hiromi Kubagawa ... [et al.] -- Self-nonself recognition through B-cell antigen receptor / Daisuke Kitamura -- How do T cells discriminate self from nonself? / Catherine Mazza, Bernard Malissen -- Fc receptors / Falk Nimmerjahn, Jeffrey V. Ravetch -- Self and nonself recognition by coreceptors on B lymphocytes: regulation of B lymphocytes by CD19, CD21, CD22, and CD72 / Kozo Watanabe, Takeshi Tsubata -- Co-receptors in the positive and negative regulation of T-cell immunity / Helga Schneider, Christopher E. Rudd.
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    An overview -- The innate immune system -- B cells and antibodies -- The magic of antigen presentation -- T cells and cytokines -- Lymphoid organs and lymphocyte trafficking -- Turning off the immune system -- Tolerance induction and MHC restriction -- Immunological memory and vaccines -- Immunopathology : the immune system gone wrong -- Cancer and the immune system -- A critique of the immune system.
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    How the NIH Can Help You Get Funded takes a novel, non-formulaic approach in teaching readers how to "write a grant" -- and much more. The authors draw on their decades of experience working with both investigators and NIH personnel to anticipate their questions and concerns and help establish a comfortable, productive partnership between them. The authors advise readers on developing each component of the grant application in order of the components' influence on the final impact score. Individual funding mechanisms are reviewed along with grantsmanship tips specific to each. Readers learn the importance of reviewer-friendly formatting and organization of the text. The final chapters cover next steps after the application has been submitted-before, during, and after the review and funding decision. Strategies for resubmitting or repurposing applications are provided for those readers whose applications do not receive awards. The authors likewise anticipate the needs of readers who do receive funding but have questions on managing and maintaining their award. Amid ever-increasing competition for government research grants, How the NIH Can Help You Get Funded is an invaluable manual for how to pursue -- and sustain -- NIH funding.
  • Principles of assessment / Olwyn Westwood and Ann Griffin -- Assessment of knowledge / Steve Capey -- Development of skills competence assessment / Alison Sturrock -- Assessment of performance / Gavin Johnson and Allison Wiseman -- Assessment of professionalism / Deborah Gill -- Setting the standard in assessments / Steve Capey -- Feedback and assessment / Ann Griffin, Sophie Park, and Catherine O'Keeffe -- Psychometrics in medical education assessments / Katherine Woolf -- Examiners and examination boards / Olwyn Westwood -- Future developments in assessment and feedback / Jane Dacre.
  • Ophthalmoscope, the fundus oculi, and central and peripheral vision -- Loss of vision -- The abnormal retina -- Eye movements, diplopia, and cranial nerves 3, 4, and 6 -- Ptosis and the pupils: myasthenia gravis and other diseases of the eye and eyelid muscles -- Nystagmus -- Conjugate gaze palsies and forced conjugate deviation -- Cranial nerves 1, 5, and 7 -- Cranial nerves 8-12 -- The upper limb -- The lower limb -- Stance, gait, and balance -- Reflexes -- Sensation -- The cerebellum -- The corticospinal system -- Higher cortical functions: intelligence and memory -- Disorders of speech -- Neurological examination instruments.
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  • The aging of America : the problem of pain in older adults -- Pain assessment in the older patient -- Pain medication management for older adults -- Complementary methods for pain relief -- Acute pain management -- Chronic pain management -- Interventional pain management for older patients -- Palliative care.
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    Why read papers at all? -- Searching the literature -- Getting your bearings: what is this paper about? -- Assessing methodological quality -- Statistics for the non-statistician -- Papers that report drug trials -- Papers that report diagnostic or screening tests -- Papers that summarise other papers (systematic reviews and meta-analyses) -- Papers that tell you what to do (guidelines) -- Papers that tell you what things cost (economic analyses) -- Papers that go beyond numbers (qualitative research) -- Papers that report questionnaire research (surveys) -- Getting evidence into practic.
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    Why read papers at all? -- Searching the literature -- Getting your bearings : what is this paper about? -- Assessing methodological quality -- Statistics for the non-statistician -- Papers that report trials of drug treatments and other simple interventions -- Papers that report trials of complex interventions -- Papers that report diagnostic or screening tests -- Papers that summarise other papers (systematic reviews and meta-analyses) -- Papers that tell you what to do (guidelines) -- Papers that tell you what things cost (economic analyses) -- Papers that go beyond numbers (qualitative research) -- Papers that report questionnaire research -- Papers that report quality improvement case studies -- Getting evidence into practice.
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  • Stroke is a leading cause of death and disability throughout the world. Intravenous lytics and endovascular stroke treatment were demonstrated to be highly beneficial in clinical trials and in achieving net cost savings. However, time is of the essence in the management of stroke as for every minute that stroke is left untreated, an estimated 1.9 million neurons are destroyed. An optimized stroke pathway can dramatically impact patient outcome. Every medical service will differ.This book offers a concise and practical guide on how to set up and efficiently run an acute stroke service tailored to the needs of the individual center as a provider of primary, secondary, or tertiary care. It documents the essential knowledge on current imaging and treatment options and offers guidance in organizing a site-specific stroke pathway that will ensure the quickest possible provision of treatment, thereby optimizing benefit to the patient and maximizing cost-effectiveness. The authors played an integral part in the development and operation of one of Europe's most successful early stroke centers and also have experience of the factors that can undermine the creation of world-class stroke units. On this basis, they address the key aspects of the stroke pathway and explain how organizing this can reduce the number of severe outcomes by ensuring that appropriate steps are taken during the early moments after stroke when intervention can make a profound difference. The challenging, multidisciplinary nature of care is emphasized, and this handbook will be an invaluable source for every member of the stroke team, including doctors, nurses, stroke coordinators, emergency and rehabilitation providers as well as hospital administrators.
  • How to Succeed at the Medical Interview provides candidates with a competitive edge. It reduces the likelihood of unexpected questions or situations and helps improve confidence before and during the medical interview. This new second edition includes updated content on changes to the structure of healthcare and how this affects both the application and interview process. It details the types of questions that will be asked at medical interviews and also provides improved guidance for overseas doctors and healthcare professionals and for those seeking to practice abroad.
  • Creating an effective learning environment -- Teaching in clinical contexts -- Workplace-based assessment and feedback -- Common problems in clinical teaching -- Next steps.
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    Structure of a scientific paper / George M. Hall -- Introductions / Richard Smith -- Methods / Gordon B. Drummond -- Results / Hans-Joachim Priebe -- Discussion / George M. Hall -- Titles, abstracts, and authors / Fiona Moss -- References / Simon Howell and Liz Neilly -- Electronic submissions / Natalie Davies -- How to write a letter / Michael Doherty -- How to prepare an abstract for a scientific meeting / Robert N. Allan -- How to write a case report / Martin Neil Rossor -- How to write a review / Paul Glasziou -- The role of the editor / Jennifer M. Hunter -- The role of the manuscript assessor / Domhnall MacAuley -- What a publisher does / Alex Williamson -- Who should be an author? / Richard Horton -- Style : what is it and why it matters / Margaret Cooter -- Ethics of publication / Michael J.G. Farthing -- Electronic publishing / Craig Bingham -- Open access / Mark Ware.
  • Grantsmanship : necessary but not sufficient strategies for success / Willo Pequegnat -- Community-based collaborations : designing, conducting and sustaining prevention programs / Mary M. McKay, Carl C. Bell, and Clair A. Blake -- Funding opportunity announcements / Jean Noronha -- Selecting the appropriate research mechanism : finding the right match / Cheryl Anne Boyce and Courtney Ferrell Aklin -- Selecting issues and hypotheses for a research proposal / Spero M. Manson -- Electronic submission process / Jean Noronha -- The review process / Anita Miller Sostek -- Common mistakes in proposal writing and how to avoid them / Susan Folkman and Willo Pequegnat -- Reading between the lines of your summary statement / William Lyman, Bonita Stanton, and Willo Pequegnat -- The award process / Ellen Stover -- So you were awarded your grant, now what? / Seth C. Kalichman -- Developing a theoretical framework and rationale for a research proposal / Gregory M. Herek -- How do you formulate a testable exciting hypothesis? / Robyn Dawes -- Qualitative inquiry : an end not just a means / Margaret E. Bentley, Elizabeth E. Tolley, and Willo Pequegnat -- Issues in assessment in research proposals / Helena Chmura Kraemer -- Using technology and the Internet in research / Joseph A. Konstan and William West -- Designing an intervention / Jose Szapocznik, Willo Pequegnat, and Guillermo Prado -- Designing an adequate control group / Thomas J. Coates -- Human subject protection and special population issues / Christine Moretto Wishnoff ... [et al.] -- Animal welfare and behavior / Kevin Quinn and Richard Nakamura -- Developing a resume and presenting your research team / Rayford Kytle and Cheryl Anne Boyce -- Writing the data analysis plan / A.T. Panter -- Developing a budget and financial justification / Masud Rahman -- Developing a quality control/quality assurance program / Lisa C. Strader and Willo Pequegnat -- Applying for training, career development, and early-stage research grants / Donna Mayo -- Cost-effectiveness : a key step in technology transfer / Steven D. Pinkerton and David R. Holtgrave -- Disseminating research findings to service providers and communities / Jeffrey A. Kelly -- Developing a plan for data sharing / Christine Bachrach and Michael Spittel.
  • "This Element is an excerpt from 'The truth about the new rules of business writing' by Natalie Canavor and Claire Meirowitz. How to write successful proposals and grant applications"--Resource description page.
  • How we die now : Americans aging and dying in the twenty-first century -- The paradox of long-term care : we need it; we fear it -- Transitioning together : living, working, aging, and dying at Winthrop House -- Lessons from the end of life : what workers learn from helping others die -- Mutual interdependency : belonging, recognition, and the rewards of caring for one another.
  • HOX gene expression 2007
  • Regulation of hox activity : insights from protein motifs / Samir Merabet ... [et al.] -- Cis-regulation in the drosophila : bithorax complex / Robert K. Maeda and François Karch -- Maintenance of hox gene expression patterns / Samantha Beck ... [et al.] -- Control of vertebrate hox clusters by remote and global cis-acting regulatory sequences / François Spitz -- The early evolution of hox genes : a battle of belief? / Bernd Schierwater and Kai Kamm -- Evolution of hox complexes / David E.K. Ferrier -- The nematode story : hox gene loss and rapid evolution / Aziz Aboobaker and Mark Blaxter -- Are the deuterostome posterior hox genes a fast-evolving class? / Robert Lanfear -- Hox genes and the body plans of chelicerates and pycnogonids / Wim G.M. Damen -- Hox3/zen and the evolution of extraembryonic epithelia in insects / Urs Schmidt-Ott, Ab. Matteen Rafiqi and Steffen Lemke -- Hox genes and brain development in drosophila / Heinrich Reichert and Bruno Bello -- Homeosis and beyond : what is the function of the hox genes? / Jean S. Deutsch.
  • HPV and cancer 2012
    "HPV and Cancer" is a concise read that covers all aspects of the Human Papilloma Virus as it relates to human cancers. While written by professionals, it design to be understandable by those that are not in the field, yet it has the technical details that professionals want to stay abreast of this changing field. The book starts out the history of HPV and progresses into the molecular biology of the virus and our current understand of the structure and functions of the proteins and genes it encodes.
  • Infection and Cervical Cancer: An Old Fact with a Recent Solution / Lutz Gissman -- Human Papillomavirus: Natural History of a Viral Infection in the Genesis of a Cancer / Franco Borruto and Ciro Comparetto -- The Immunobiology of Human Papillomavirus Associated Oncogenesis / Peter L. Stern and Mark H. Einstein -- The Epidemiology of Cervical Cancer / Xavier Castellsagué, Laia Bruni, Laia Alemany, Mireia Diaz and Silvia de Sanjosé, et al. -- The Basic Elements of a Correct Diagnosis: From Cytohistopathology to Screening / Franco Borruto and Ciro Comparetto -- Human Papillomavirus DNA Testing: What, How, and When / Ciro Comparetto and Franco Borruto -- Colposcopic Appearance of HPV Infection / Santiago Dexeus, Montserrat Cararach and Damian Dexeus -- Multiple Aspects of Human Papillomavirus Infections / Franco Borruto and Ciro Comparetto -- Prevention of HPV-Associated Diseases in the United States / Diane M. Harper -- Immunogenicity, Efficacy, Effectiveness and Overall Impact of HPV Vaccines / Matti Lehtinen, Pekka Nieminen, Dan Apter, Proscowa Namujju and Kari Natunen, et al. -- Treatment, Follow-up, and Prevention of Papillomavirus Infection and Cervical Cancer / Franco Borruto and Ciro Comparetto -- Therapeutic Vaccines for HPV Infection / Margaret Stanley -- Perspectives on Therapeutic HPV Vaccines: Where Are We Now? / Connie Wang, Barbara Ma, Alexander Chen, Chien-Fu Hung and T. C. Wu.
  • Anatomical sites and subsites of head and neck cancer -- Epidemiology of oral HPV infection and HPV-associated head and neck cancer -- Frequent behavioural questions with an HPV-positive malignancy of the head and neck -- The molecular biology of HPV-related head and neck cancer -- The diagnosis of HPV-related head and neck squamous cell carcinoma: Recognition of its microscopic appearance and the use of ancillary detection assays -- Clinical management of HPV-related oropharyngeal cancer -- The role of vaccines for HPV-related head and neck cancers -- The care of the HPV-negative head and neck cancer patient: Presentation, prognosis, treatment. .
  • HTML, XHTML, and the World Wide Web -- Quick start -- Anatomy of an HTML document -- Text basics -- Rules, images, and multimedia -- Links and webs -- Formatted lists -- Cascading style sheets -- Forms -- Tables -- Frames -- Executable content -- Dynamic documents -- Netscape layout extensions -- XML -- XHTML -- Tips, tricks, and hacks.
  • HTML examples -- HTML quiz test -- HTML references.
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  • HTTP the definitive guide 2002
    ProQuest Safari
  • History -- Clinical features -- Pregnancy & infertility -- Venous thrombosis -- Migraine & stroke -- Movement disorders & seizures -- Neuro psychiatric aspects -- Spinal cord, multiple sclerosis, peripheral nerves -- The Heart The arteries -- Kidneys -- Skin -- The eye -- Ear, nose & throat -- Lungs -- Liver & gut -- Bones & joints -- Blood -- Catastrophic APS -- Diagnosis -- Treatment -- Aetiology -- genetics vs. environment -- Links to other diseases -- The world map.
  • Hughes Syndrome: Highways and Byways is a handy and easy-to-read guide to the main features of Hughes syndrome. There has been worldwide interest in this 'new' syndrome (first described in 1983). A clotting tendency which can potentially affect any organ in the body, it is: responsible for 1 in 5 recurrent miscarriages (now successfully treated with aspirin and heparin) responsible for 1 in 5 young (under 45) strokes a major cause of early heart attacks responsible for 1 in 5 deep vein thromboses an important cause of migraine.
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  • Foreword -- Preface -- Acknowledgementsi -- Dedication -- Chapter 1 Problems of concept and nomenclature of benign disorders of the breast -- Key points and new developments -- The source of the problem -- History -- The present and the future -- References -- Chapter 2 History of benign breast disease -- Introduction -- Sir Astley Paston Cooper, Bt. FRS DCL GCH. 1768-1841 -- Alfred Velpeau. 1785-1867 -- John Birkett FRCS Fellow of the Linnean Society. 1815-1904 -- George Lenthal Cheatle. 1865-1951 -- Joseph Colt Bloodgood. 1867-1935 -- Charles F. Geschickter. 1901-? -- An analysis of the contributions of these six men -- References -- Chapter 3 Breast anatomy and physiology -- Key points and new developments -- Development -- Changes at puberty -- Adult anatomy -- Microscopic anatomy -- Biochemical control of breast epithelium -- Cyclical changes in breast epithelium -- Changes during pregnancy and lactation -- Postmenopausal involution -- References -- Chapter 4 Aberrations of normal development and involution (ANDI): a concept -- of benign breast disorders based on pathogenesis -- Key points and new developments -- Introduction -- Recognition of the normality of much benign breast disease -- Problems with the conventional view of benign breast disease -- The physiological processes underlying the ANDI concept -- A framework based on pathogenesis -- Reasons for including various benign breast disorders as part of ANDI -- An extension of the concept of ANDI to include most benign breast disorders? -- Implications for the management of benign breast disorders -- Aberration to disease? -- Recent developments having a bearing on the ANDI concept -- References -- Chapter 5 The approach to diagnosis and assessment of breast lumps -- Key points and new developments -- Part 1: The differential diagnosis and clinical assessment of breast lumps -- Clinical assessment of a breast lump -- Features of individual lesions -- Follow-up after assessment and/or benign breast biopsy -- Management of recurrent lumps following biopsy -- Breast masses related to different life periods -- Part 2: Triple assessment and organization of the breast clinic -- Fine needle aspiration cytology -- Ultrasound in triple assessment -- Wide-bore needle biopsy -- Mammotome or vacuum-assisted biopsy -- Organization of clinics -- Medico-legal issues -- References -- Chapter 6 Imaging of the breast -- Key points and new developments -- Introduction -- Breast density -- Mammography -- Breast ultrasound -- Breast magnetic resonance imaging -- Biopsy techniques -- Breast localization techniques -- References -- Chapter 7 Fibroadenoma and related tumours -- Key points and new developments -- Terminology -- Fibroadenoma simplex -- Cancer and fibroadenoma -- Multiple fibroadenomas -- Giant fibroadenoma -- Phyllodes tumour and phyllodes sarcoma (cystosarcoma phyllodes) -- Pseudoangiomatous hyperplasia -- References -- Chapter 8 Breast pain and nodularity -- Key points and new developments -- Introduction -- Historical note -- Frequency of breast pain -- Mastalgia in breast cancer -- Classification -- Aetiology of mastalgia and nodularity -- Management of patients with mastalgia -- Natural history of mastalgia -- Plan of management for patients with mastalgia -- Mastalgia in the postmenopausal patient -- Patients with refractory mastalgia -- The relationship of cyclical mastalgia to premenstrual stress -- Conclusion -- References -- Chapter 9 Sclerosing adenosis, radial scar and complex sclerosing lesions -- Key points and new developments -- Introduction -- Sclerosing adenosis -- Radial scar and complex sclerosing lesions -- References -- Chapter 10 Cysts of the breast -- Key points and new developments -- Introduction -- Pathology -- Incidence -- Pathogenesis and cyst types -- Aetiology -- Clinical features -- Age -- Natural history -- Investigation -- Differential diagnosis -- management -- Galactocele -- Papillary tumours associated with macrocysts -- References -- Chapter 11 The duct ectasia/periductal mastitis complex -- Key points and new developments -- Introduction -- Historical survey -- Pathology and pathogenesis of duct ectasia/periductal mastitis -- The development of the duct ectasia/periductal mastitis complex -- The clinical spectrum of duct ectasia/periductal mastitis -- Breast masses associated with periductal mastitis -- Frequency of duct ectasia/periductal mastitis -- Radiology -- Management -- The consequences and results of operations for duct actasia -- Recurrent infection after surgery for periductal mastitis -- References -- Chapter 12 Disorders of the nipple and areola -- Key points and new developments -- Introduction -- Nipple inversion and retraction -- Cracked nipples -- Nipple crusting -- Erosive adenomatosis -- Syringomatous adenoma -- Nodular mucinosis -- Simple fibroepithelial polyp -- Eczema -- Leiomyoma -- Traumatic lesions -- Nipple pain -- Nipple disease and HIV infection -- Montgomery's glands -- Sebaceous cyst of the nipple -- Viral infections -- Hidradenitis suppurativa of the areola -- References -- Chapter 13 Nipple discharge -- Key points and new developments -- Introduction -- Definition -- Incidence -- Character and significance of discharge -- Pathology underlying nipple discharge -- Assessment -- Management -- References -- Chapter 14 Infections of the breast -- Key points and new developments -- Introduction -- Lactational breast infection -- Subclinical mastitis -- Nonlactational breast abscess -- Infections in immunocompromised patients -- Iatrogenic abscess -- Specific infections of the breast -- Infections of associated structures -- References -- Chapter 15 Congenital and growth disorders -- Key points and new developments -- Introduction -- Developmental anomalies -- Premature breast development -- Hypertrophic abnormalities of the breast -- Excessive postlactational involution -- Genetic abnormalities involving the breast -- Surgical treatment -- References -- Chapter 16 The male breast -- Key points and new developments -- Development of the male breast -- Gynaecomastia -- Other male breast disease -- References -- Chapter 17 Miscellaneous conditions -- Introduction -- Trauma -- Fat necrosis -- Paraffinoma and silicone reactions -- Lipoma -- Hamartoma (adenolipoma) -- Oedema of the breast -- The post-irradiated breast -- Fibrous disease of the breast -- Fibromatosis (desmoid tumour) -- Nodular fasciitis -- Diabetic mastopathy -- Idiopathic granulomatous mastitis (non-specific granulomatous disease) -- Sarcoid -- Amyloid -- Blood vessels -- Atherosclerosis and aneurysm -- Mondor's disease -- Infarction -- Skin-related conditions -- Hidradenitis suppurativa of the breast -- Tumours of nerve origin -- Granular cell tumour (myoblastoma) -- Artefactual disease of the breast -- Foreign bodies -- Mammalithiasis -- Phantom breast syndrome -- Mammary mucocele-like lesion -- Breast tumour of pregnancy (lactating adenoma) -- Collagenous spherulosis of the breast -- Gynaecomastia-like lesions in women -- References -- Chapter 18 Operations -- Introduction -- Tissue diagnosis in the clinic -- Removal of giant fibroadenoma and phyllodes tumour -- Microdochectomy -- Excision of mammary duct fistula -- Major duct excision (Adair/Urban/Hadfield) -- Drainage of a lactational breast abscess -- Subcutaneous mastectomy in male patients -- Subcutaneous mastectomy or skin sparing mastectomy in women -- Operations for inverted nipples -- References -- Chapter 19 Psychological aspects of benign breast disease -- Key points and new developments -- Introduction -- Psychological problems resulting from presenting with breast problems -- Psychological abnormality as a cause of benign breast disease -- References -- Chapter 20 Risk assessment and management -- Summary -- Breast cancer: the disease -- The breast cancer genes -- Conclusion -- References -- Index.
  • 1. Neural progenitors / Dustin R. Wakeman ... [et al.] -- 2. Multipotent stromal cells (hMSCs) / Margaret Wolfe ... [et al.] -- 3. Endothelium / Sangmo Kwon, Takayuki Asahara -- 4. Lung / Rabindra Tirouvanziam, Megha Makam, Bruno Péault -- 5. Eye / Maria Notara ... [et al.] -- 6. Colon / F. Iovino ... [et al.] -- 7. Spermatogonia / Makoto C. Nagano, Jonathan R. Yeh, Khaled Zohni -- 8. Hair follicle pluripotent stem (hfPS) cells / Robert M. Hoffman -- 9. Pancreas / Fang-Xu Jiang, Grant Morahan -- 10. Prostate / C. Foley ... [et al.].
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    The art of anatomy / Benjamin A. Rifkin -- Vesalius -- Estienne -- Valverde -- Eustachi -- Casseri and Spieghel -- Bidloo and Cowper -- Ruysch -- Cheselden -- Albinus -- Gautier d'Agoty -- Smellie and Hunter -- Gamelin -- Bell -- Ballie, Willan, Cruveilhier, and Carswell -- Cloquet and Sarlandière -- Bourgery -- Quain, Maclise, and Ellis -- Gray -- Braune -- Anatomy in the digital age / Michael J. Ackerman -- McCracken.
  • Human anatomy color atlas and textbook. 5th ed. 2008
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  • Therapeutic control of hepatitis C virus: the role of neutralizing monoclonal antibodies / Z. Y. Keck ... [et al.] -- Antibodies for HIV treatment and prevention: window of opportunity? / M. Huber ... [et al.] -- Human monoclonal antibody and vaccine approaches to prevent human rabies / T. Nagarajan ... [et al.] -- Immunoprophylaxis of RSV infection: advancing from RSV-IGIV to palivizumab and motavizumab / H. Wu ... [et al.] -- The molecular basis of antibody protection against West Nile virus / E. Mehlhop ... [et al.] -- Exploring the native human antibody repertoire to create antiviral therapeutics / S. K. Dessain ... [et al.].
  • Introduction to ABC protein and gene organization -- Nomenclature -- Overview of human ABC gene subfamilies -- ABC genes and human genetic disease -- Mouse knockouts -- Multidrug resistance and cancer therapy -- Phylogenetic analysis of human ABC genes -- Mouse ABC genes -- Drosophila ABC genes -- ABCA genes -- ABCB genes -- ABCC genes -- ABCD genes -- ABCE genes -- ABCF genes -- ABCG genes.
  • Introduction: Why Human Auditory Cortex? / David Poeppel and Tobias Overath -- Part 1. The Methods -- Architecture, Connectivity, and Transmitter Receptors of Human Auditory Cortex / Stephanie Clarke and Patricia Morosan -- Invasive Research Methods / Matthew A. Howard, Kirill V. Nourski and John F. Brugge -- Recording Event-Related Brain Potentials: Application to Study Auditory Perception / Claude Alain and István Winkler -- Magnetoencephalography / Srikantan Nagarajan, Rodney A. Gabriel and Alexander Herman -- Hemodynamic Imaging: Functional Magnetic Resonance Imaging / Thomas M. Talavage, Ingrid S. Johnsrude and Javier Gonzalez-Castillo -- Part 2. The Principal Computational Challenges -- Coding of Basic Acoustical and Perceptual Components of Sound in Human Auditory Cortex / Deborah Hall and Daphne Barker -- Auditory Object Analysis / Timothy D. Griffiths, Christophe Micheyl and Tobias Overath -- Speech Perception from a Neurophysiological Perspective / Anne-Lise Giraud and David Poeppel -- Cortical Processing of Music / Robert J. Zatorre and Jean Mary Zarate -- Multisensory Role of Human Auditory Cortex / Virginie van Wassenhove and Charles E. Schroeder -- Redefining the Functional Organization of the Planum Temporale Region: Space, Objects, and Sensory-Motor Integration / Gregory Hickok and Kourosh Saberi -- Toward a Theory of Information Processing in Auditory Cortex / Peter Cariani and Christophe Micheyl.
  • 1. Overview and Issues in Human Auditory Development / Lynne A. Werner -- 2. Morphological and Functional Ear Development / Carolina Abdala and Douglas H. Keefe -- 3. Morphological and Functional Development of the Auditory Nervous System / Jos J. Eggermont and Jean K. Moore -- 4. Development of Auditory Coding as Reflected in Psychophysical Performance / Emily Buss, Joseph W. Hall III, and John H. Grose -- 5. Development of Auditory Scene Analysis and Auditory Attention / Lori J. Leibold -- 6. Development of Binaural and Spatial Hearing / Ruth Y. Litovsky -- 7. Development of Speech Perception / Robin Panneton and Rochelle Newman -- 8. Development of Pitch and Music Perception / Laurel J. Trainor and Andrea Unrau -- 9. Atypical Auditory Development and Effects of Experience / Laurie S. Eisenberg, Karen C. Johnson, Sophie E. Ambrose, and Amy S. Martinez.
  • This textbook is specifically designed for upper-division undergraduate or graduate students in life science or pre-medical majors including dentistry or pharmacology, who are required to take a biochemistry or medical biochemistry course, but who are not necessarily biochemistry majors. The book adopts a unique approach to the topic compared with other biochemistry textbooks currently available, in that each biochemical subject is introduced by a human disease relating the biochemical principles to be developed in that chapter. The goal is to make biochemistry more meaningful to the student who is not normally shown the connection between biochemistry and medicine. This book: includes an abundance of figures; emphasizes human biochemistry; and introduces each chapter with a relevant disease or clinical relationship.
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    External anatomy of the brain -- Transverse sections of the spinal cord -- Transverse sections of the brainstem -- Building a brain: three-dimensional reconstructions -- Coronal sections -- Horizontal sections -- Sagittal sections -- Functional systems -- Clinical imaging.
  • External anatomy of the brain -- Transverse sections of the spinal cord -- Transverse sections of the brainstem -- Building a brain: three-dimensional reconstructions -- Coronal sections -- Axial sections -- Sagittal sections -- Functional systems -- Clinical imaging.
  • Mammalian cerebral cortex: embryonic development and cytoarchitecture -- Human motor cortex: development and cytoarchitecture -- The mammalian pyramidal neuron: development, structure, and function -- Human motor cortex first lamina: development and cytoarchitecture -- Human motor cortex excitatory-inhibitory neuronal systems: development and cytoarchitecture -- Human cerebral cortex intrinsic microvascular system: development and cytoarchitecture -- Human motor cortex first lamina and gray matter special astrocytes: development and cytoarchitecture -- New developmental cytoarchitectonic theory and nomenclature -- Cat motor cortex: development and cytoarchitecture -- The rapid Golgi reaction: a personal quest.
  • Molecular epidemiology of human papillomavirus infection -- / Gillison, M.L -- Molecular pathogenesis of the human papillomavirus / Mao, C.-P., Wu, T.-C -- Human papillomavirus vaccines / Roden, R., Hung, C.-F., Monie, A., Wu, T.-C -- Hepatitis C virus genetics and the discovery of mechanism based inhibitors of the Ns3/4A protease and NS5B polymerase / LaFemina, R.L -- Role of the hepatitis B virus in hepatocellular carcinoma / Toh, S.-T., Lee, C.G -- Carcinogenesis induced by hepatitis B virus / Cougot, D., Buendia, M.-A., Neuveut, C -- Disease and pathogenesis associated with Epstein-Barr virus / Ambinder, R.F -- The biology and molecular biology underlying Epstein-Barr virus oncogenesis / Martin, H.J., Hayward, S.D -- Kaposi-sarcoma-associated herpesvirus clinical diseases and viral pathogenesis / Damania, B., Dittmer, D.P. -- Molecular biology of human herpesvirus 8 neoplasia / Chaudhary, P.M., Nicholas, J -- Human cancer viruses. Human T cell leukemia virus type 1 and 2: mechanisms of pathogenesis / Arnold, J., Green, P.L -- Chromosomal instability and human T cell leukemia virus 1 transformation / Chi, Y.-H., Jeang, K.-T.
  • Establishment and maintenance of normal human keratinocyte cultures / Claire Linge -- Cultivation of normal human epidermal melanocytes in the absence of phorbol esters / Mei-Yu Hsu, Ling Li, and Meenhard Herlyn -- Isolation and culture of human osteoblasts / Alison Gartland ... [et al.] -- Human osteoclast culture from peripheral blood monocytes : phenotypic characterization and quantitation of resorption / Katherine A. Buckley ... [et al.] -- Human chondrocyte cultures as models of cartilage-specific gene regulation / Mary B. Goldring -- Human myoblasts and muscle-derived SP cells / Grace K. Pavlath and Emanuela Gussoni -- Cell cultures of autopsy-derived fibroblasts / Volker Meske, Frank Albert, and Thomas G. Ohm -- Primary culture and differentiation of human adipocyte precursor cells / Vanessa van Harmelen, Thomas Skurk, and Hans Hauner -- Human mononuclear phagocytes in tissue culture / Yona Keisari -- Purification of peripheral blood natural killer cells / Bice Perussia and Matthew J. Loza -- Human fetal brain cell culture / Mark P. Mattson -- Culturing human schwann cells / Victor J. Turnbull -- Well-differentiated human airway epithelial cell cultures / M. Leslie Fulcher ... [et al.] -- Isolation and culture of human alveolar epithelial cells / Carsten Ehrhardt, Kwang-Jin Kim, and Claus-Michael Lehr -- A new approach to primary culture of human gastric epithelium / Pierre Chailler and Daniel Ménard -- Isolation and culture of human colon epithelial cells using a modified explant technique employing a noninjurious approach / Hamid A. Mohammadpour -- Isolation and culture of human hepatocytes / Martin Bayliss and Graham Somers -- Glomerular epithelial and mesangial cell culture and characterization / Heather M. Wilson and Keith N. Stewart -- Isolation and culture of human renal cortical cells with characteristics of proximal tubules / Gabrielle M. Hawksworth -- Culture of parathyroid cells / Per Hellman -- Long-term culture and maintenance of human islets of langerhans in Memphis serum-free media / Daniel W. Fraga, A. Osama Gaber, and Malak Kotb -- Primary culture of human antral endocrine and epithelial cells / Susan B. Curtis and Alison M. J. Buchan -- Conjunctiva organ and cell culture / Monica Berry and Marcus Radburn-Smith -- Establishment and maintenance of in vitro cultures of human retinal pigment epithelium / Martin J. Stevens.
  • Pt. 1. Multistep models -- pt. 2. Prostate cancer/stem cells -- pt. 3. Breast cancer/stem cells -- pt. 4. Multistep/genes.
  • Orientation -- Development -- Gross anatomy -- Blood supply, meninges and cerebrospinal fluid circulation -- Brain slices -- Topography of spinal cord, brain stem and cerebellum -- Diencephalon: introduction and epithalamus -- Diencephalon: dorsal thalamus -- Diencephalon: ventral thalamus or subthalamus -- Diencephalon: hypothalamus -- Telencephalon: introduction and olfactory system -- Telencephalon: hippocampus and related structures -- Telencephalon: amygdala and claustrum -- Telencephalon: basal ganglia -- Telencephalon: neocortex -- General sensory systems and taste -- Vestibular system -- Auditory system -- Visual system -- Cerebellum -- Motor systems -- Reticular formation and the monoaminergic and cholinergic cell groups -- Greater limbic system.
  • Part A: Introduction -- 1. The Expanding World of hCG -- 2. History and Introduction to Human Chorionic Gonadotropin (hCG): One Name for at Least Three Independent Molecules -- 3. Introduction to Pregnancy Implantation, Villous Formation, and Hemochorial Placentation -- Part B: Genetics, Synthesis, Secretion, Structure, and Degradation of hCG -- 4. The Molecular Genetics of hCG -- 5. Structure, Synthesis, Secretion, and Function of hCG -- 6. Comparison of the Structures of hCG and Hyperglycosylated hCG -- 7. Structures of Free a- and ss-Subunits -- 8. Glycobiology of hCG -- 9. Degradation Products of hCG, Hyperglycosylated hCG, and Free ss-Subunit -- 10. Three-Dimensional Structure of hCG -- Part C: Biological Function of hCG -- 11. Paradigm Shift on the Targets of hCG Actions -- 12. The hCG Receptor -- 13. Biological Function of Hyperglycosylated hCG -- 14. Biological Function of the Free ss-Subunit: Expression and Treatment Target in Cancer -- Part D: Clinical Applications -- 15. Use of hCG in Reproductive Dysfunction -- 16. hCG in Assisted Reproduction -- 17. Illicit Use of hCG in Dietary Programs and Use to Promote Anabolism -- Part E: hCG Tests -- 18. Antibodies for Intact hCG, for Total hCG, for Free Subunits, Glycosylation Variants, and for hCG Fragments -- 19. Quantitative hCG Assays -- 20. False Positive hCG Assays -- 21. Specificity of Different hCG Assays -- 22. Point-of-Care Pregnancy Tests -- 23. Over-the-Counter Pregnancy Tests -- 24. hCG Standards -- Part F: Test Applications -- 25. Background hCG -- 26. Pregnancy Testing -- 27. Predicting Spontaneously Aborted (SAB) Pregnancies -- 28. hCG, Hyperglycosylated hCG, and Free ss-Subunit in Predicting Down Syndrome Pregnancies and Preeclampsia -- 29. hCG in Monitoring Gestational Trophoblastic Diseases -- 30. Use of Hyperglycosylated hCG as a Unique Marker of Gestational Trophoblastic Neoplasms -- 31. Pituitary hCG and Familial hCG -- 32. hCG, Free ss-Subunit, and ss-Core Fragment as Markers of Malignancies -- Part G: Basic Methods -- 33. hCG and Hyperglycosylated hCG Purification and Analysis from Serum, Urine, and Culture Fluids -- 34. Dissociation, Desialylation, and Cleavage of hCG -- 35. hCG and Free ss-Subunit Producing Cell Lines -- Part H: Evolution, Summary, and the Future -- 36. Evolution of hCG, Evolution of Humans, and Evolution of Human Pregnancy Disorders and Cancer -- 37. Summary: hCG a Remarkable Molecule -- 38. hCG and the Future.
  • pt. 1. Human chromosome methods and nomenclature -- pt. 2. Chromosome heteromorphism (summaries) -- pt. 3. Fragile sites -- pt. 4. Copy number vairiants.
  • Human cytomegalovirus genome / E. Murphy and T. Shenk -- Human cytomegalovirus microRNAs / P.J. Fannin Rider ... [et al.] -- Mutagenesis of the cytomegalovirus genome / Z. Ruzsics and U.H. Koszinowski -- Cytomegalovirus cell tropism / C. Sinzger, M. Digel and G. Jahn -- Virus entry and innate immune activation / M.K. Isaacson, L.K. Juckem and T. Compton -- Functions of human cytomegalovirus tegument proteins prior to immediate early gene expression / R.F. Kalejta -- Initiation of cytomegalovirus infection at ND10 / G.G. Maul -- Functional roles of the human cytomegalovirus essential IE86 protein / M.F. Stinski and D.T. Petrik -- Nuts and bolts of human cytomegalovirus lytic DNA replication / G.S. Pari -- Interactions of human cytomegalovirus proteins with the nuclear transport machinery / T. Stamminger -- Structure and formation of the cytomegalovirus virion / W. Gibson -- Human cytomegalovirus modulation of signal transduction / A.D. Yurochko -- Chemokines and chemokine receptors encoded by cytomegaloviruses / P.S. Beisser ... [et al.] -- Subversion of cell cycle regulatory pathways / V. Sanchez and D.H. Spector -- Modulation of host cell stress responses by human cytomegalovirus / J.C. Alwine -- Control of apoptosis by human cytomegalovirus / A.L. McCormick -- Aspects of human cytomegalovirus latency and reactivation / M. Reeves and J. Sinclair -- Murine model of cytomegalovirus latency and reactivation / M.J. Reddehase ... [et al.] -- Cytomegalovirus immune evasion / C. Powers ... [et al.] -- Cytomegalovirus vaccine development / M.R. Schleiss -- Cytomegalovirus infection in the human placenta: maternal immunity and developmentally regulated receptors on trophoblasts converge / L. Pereira and E. Maidji -- Mechanisms of cytomegalovirus-accelerated vascular disease: induction of paracrine factors that promote angiogenesis and wound healing / D.N. Streblow ... [et al.] -- Manifestations of human cytomegalovirus infection: proposed mechanisms of acute and chronic disease / W. Britt.
  • Nomenclature and molecular biology of the human sulfotransferase family / Rebecca Blanchard -- Structure and function of sulfotranserases / Jyrki Taskinen and W.H. Coughtrie -- PAPS and sulfoconjucation / Nancy B. Schwartz -- Sulfate conjugation: pharmacogenetics and pharmacogenomics / by Weinshilboum & Adjei -- Molecular cloning of the human cytosolic sulfotransferases / by C.N.Falany ... [et al.] -- Sulfotransferases in the human fetus and neonate / by Stanley, Coughtri and Hume -- Sulfation of thyroid hormones / by Monique H.A. Kester, Michael W.H. Coughtrie and Theo J. Vissor -- Estrogen sulfotransferase in breast cancer / by Pasqualini and Chetrite -- Sulfation of drugs / by Pacifici -- Human sult1a sulfotransferases / by Nadine Hempel ... [et al.] -- Hydroxysteroid sulfotransferases sult2a1, sult2b1a and sult2b1b / by Charles A. Strott -- Species differences in cytosol sulfotoransgerases / Kiyoshi Nagata, Miki Shimada, and Yasushi Yamazoe -- Activiation and inactivation of carconogens and mutagens by human sulfotranserases / by Hansruedi Glatt.
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    Bioethics and the question of human dignity / Adam Schulman -- Human dignity and respect for persons : a historical perspective on public bioethics / F. Daniel Davis -- How to protect human dignity from science / Daniel C. Dennett -- Human dignity and the mystery of the human soul / Robert P. Kraynak -- Commentary on Kraynak / Daniel C. Dennett -- Commentary on Dennett / Robert P. Kraynak -- Commentary on Dennett / Alfonso Gómez-Lobo -- Human dignity from a neurophilosophical perspective / Patricia S. Churchland -- Commentary on Churchland / Gilbert Meilaender -- Human uniqueness and human dignity : persons in nature and the nature of persons / Holmes Rolston III -- Human dignity and the future of man / Charles Rubin -- Dignity and enhancement / Nick Bostrom -- Commentary on Bostrom / Charles Rubin -- Human dignity and public discourse / Richard John Neuhaus -- Modern and American dignity / Peter Augustine Lawler -- Human dignity : exploring and explicating the Council's vision / Gilbert Meilaender -- Commentary on Meilaender and Dennett / Peter Augustine Lawler -- Commentary on Meilaender and Lawler / Diana Schaub -- Defending human dignity / Leon R. Kass -- Kant's concept of human dignity as a resource for bioethics / Susan M. Shell -- Human dignity and political entitlements / Martha Nussbaum -- Commentary on Nussbaum, Shell, and Kass / Diana Schaub -- The irreducibly religious character of human dignity / David Gelernter -- The nature and basis of human dignity / Patrick Lee and Robert P. George -- Two arguments from human dignity / Paul Weithman -- Dignity and bioethics : history, theory, and selected applications / Daniel P. Sulmasy -- Human dignity and the seriously ill patient / Rebecca Dresser -- The lived experience of human dignity / Edmund D. Pellegrino.
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    Deeply touched by the tragedies of botched abortions that they witnessed as medical students and young physicians in Chile in the 1970s and later around the world, the authors have attempted in this book, to establish a framework for dialogue to replace the polarization that exists today.
  • This concise work on embryo transfer is yet another contribution to the persevering effort to disseminate latest information on the science and skill of performing a traumatic and successful embryo transfer. It is the most critical culmination of the assisted reproductive technology (ART) stimulation cycle, and a rate-limiting step in dictating the success of treatment. The well-worded chapters draw the reader's attention to significant aspects before initiating the actual embryo transfer, such as possible causes of failure at the embryo transfer stage, uterine evaluation, mock embryo transfer (ET), experience of the physician, and the use of ultrasound-guidance to monitor ET. The protocol for difficult transfers, variables that affect the success of ET, and the influence of the catheter used for ET have also been dealt with. The unique feature of this book is its pragmatic approach that can translate into solutions to the numerous frustrating ART failures that more often than not, may be attributed to an inefficient ET procedure. It helps the reader understand the integrity of embryo transfer, unravel its obvious simplicity and bridge the success between the several steps of ART. By highlighting the impeding problems associated with ET procedure and providing valid, scientific solutions, this stimulating edition will help the readers improve the ART success rates in their clinical practice. .
  • Master the concepts you need to know with Human Embryology and Developmental Biology. Dr. Bruce M. Carlson's clear explanations provide an easy-to-follow "road map" through the most up-to-date scientific knowledge, giving you a deeper understanding of the key information you need to know for your courses, exams, and ultimately clinical practice. Visualize normal and abnormal development with hundreds of superb clinical photos and embryological drawings.Access the fully searchable text online, view animations, answer self-assessment questions, and much more at
  • Human embryonic stem cells: isolation, maintenance and differentiation / Kursad Turksen and Tammy-Claire Troy -- Blastocyst culture for deriving human embryonic stem cells / Ariff Bongso -- Propagation of human embryonic stem cells on human feeder cells / Mark Richards and Ariff Bongso -- Derivation and maintenance of human embryonic stem cells / Michal Amit and Joseph Itskovitz-Eldor -- Isolation and characterization of human embryonic stem cells / Maisam Mitalipova and Gail Palmarini -- Routine culture and differentiation of human embryonic stem cells / Jim McWhir, Davina Wojtacha, and Alison Thomson -- Culture of human embryonic stem cells on human and mouse feeder cells / Gautam Dravid, Holly Hammond, and Linzhao Cheng -- Maintenance of human embryonic stem cells in animal serum- and feeder layer- free culture conditions / Michal Amit and Joseph Itskovitz-Eldor -- Manipulation of self-renewal in human embryonic stem cells through a novel pharmacological GSK-3 inhibitor / Noboru Sato and Ali H. Brivanlou -- Derivation of human feeders for prolonged support of human embryonic stem cells / Chui-Yee Fong and Ariff Bongso -- Transplantation of human embryonic stem cells to the chick embryo / Ronald S. Goldstein -- Derivation and characterization of neuronal precursors and dopaminergic neurons from human embryonic stem cells in vitro / Melissa Carpenter ... [et al.] -- In vitro differentiation of neural precursors from human embryonic stem cells / Xue-Jun Li and Su-Chun Zhang -- Derivation and characterization of hematopoietic cells from human embryonic stem cells / Lisheng Wang ... [et al.] -- Retroviral transduction of hematopoietic progenitors derived from human embryonic stem cells / Pablo Menendez ... [et al.] -- Genetic manipulation of human embryonic stem cells by transfection / Rachel Eiges -- Designing, testing, and validating a microarray for stem cell characterization / Yongquan Luo ... [et al.] -- Microarray approach to identify the signaling network responsible for self-renewal of human embryonic stem cells / Noboru Sato and Ali H. Brivanlou -- Massively parallel signature sequencing / Daixing Zhou ... [et al.] -- Confrontation cultures of embryonic stem cells with multicellular tumor spheroids to study tumor-induced angiogenesis / Maria Wartenberg ... [et al.] -- A novel experimental platform for investigating cancer growth and anti-cancer therapy in a human tissue microenvironment derived from human embryonic stem cells / Maty Tzukerman and Karl L. Skorecki -- The analysis of mitochondria and mitochondrial DNA in human embryonic stem cells / Justin C. St. John ... [et al.].
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    Biology of embryonic stem cells / M.B. Morris ... [et al.] -- Characteristics of human embryonic stem cells, embryonal carcinoma cells and embryonic germ cells / M.J. Shamblott and J. Sterneckert -- Adult stem cell plasticity / R.E. Schwartz and C.M. Verfaillie -- Human and murine embryonic stem cell lines : windows to early mammalian development / J.S. Odorico and Su-Chun Zhang -- Human mesenchymal stem cells and multilineage differentiation to mesoderm lineages / V. Sottile and J. McWhir -- Trophoblast differentiation from embryonic stem cells / T.G. Golos and Ren-He Xu -- Current and future prospects for hematopoiesis studies using human embryonic stem cells / D.S. Kaufman -- Derivation of endothelial cells from human embryonic stem cells / S. Levenberg, N.F. Huang and R. Langer -- Neural specification from human embryonic stem cells / Su-Chun Zhang -- Modeling islet development through embryonic stem cell differentiation / J.S. Odorico ... [et al.]. Cardiomyocyte differentiation in human embryonic stem cell progeny / I. Kehat, J. Itskovitz-Eldor and L. Gepstein -- Genetic engineering of human embryonic stem cells / M. Drukker, S.K. Dhara and N. Benvenisty -- ES cells for transplantation : coping with immunity / J.A. Bradley, E.M. Bolton and R.A. Pedersen -- Clinical applications for human ES cells / T. Kamp and J.S. Odorico -- Production of human embryonic stem cell-derived cellular product for therapeutic use / R. Mandalam ... [et al.] -- Ethical and policy considerations in embryonic stem cell research / R. Alta Charo -- Legal framework pertaining to research creating or using human embryonic stem cells / C.E. Gulbrandsen ... [et al.] -- Genomic approaches to stem cell biology / T.S. Tanaka ... [et al.] -- Proteomics and embryonic stem cells / M.R. Sussman ... [et al.].
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    Organization and good aseptic technique in the human embryonic stem cell laboratory / Minal J. Patel, Emma L. Stephenson and Stephen L. Minger -- Sourcing human embryonic stem cell lines / Glyn Stacey -- Culture of human embryos for stem cell derivation / R. Douglas Powers and Jeannine Witmyer -- Derivation of human embryonic stem cell lines / Stephen Sullivan ... [et al.] -- Standard culture of human embryonic stem cells / Jeremy M. Crook, Rachel Horne and Alan Colman -- Chemically-defined culture of human embryonic stem cells / Julie Hsu Clark and Sheng Ding -- Phenotypic analysis of human embryonic stem cells / Jonathan S. Draper, Cheryle A. Séguin and Peter W. Andrews -- Genetic and epigenetic analysis of human embryonic stem cells / Laurie A. Boyer, Rudolf Jaenisch and Maisam Mitalipova -- In vivo characterization of human embryonic stem cells / Scott A. Noggle, Francesca M. Spagnoli and Ali H. Brivanlou -- In vitro differentiation of human embryonic stem cells / A. Henry Sathananthan and Alan Trounson -- Differentiation of human embryonic stem cells into extraembryonic cell types / Cheryle A. Séguin and Jonathan S. Draper -- Directed differentiation of human embryonic stem cells into endoderm / Kenji Osafune ... [et al.] -- Directed differentiation of human embryonic stem cells into mesoderm / Christine Mummery ... [et al.] -- Directed differentiation of human embryonic stem cells into ectoderm / Emily A. Davis ... [et al.] -- Gene targeting in human embryonic stem cells : knock out and knock in by homologous recombination / Thomas P. Zwaka -- RNA interference in human embryonic stem cells / M. William Lensch, Asmin Tulpule and Holm Zaehres -- Generation of human gene reporters using bacterial artificial chromosome recombineering / Andrew J. Washkowitz and David A. Shaywitz.
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    The nature of stem cells -- The dividing cell -- The egg -- The activated egg -- The zygote -- Blastomere cleavage -- Early nuclear transfer technology -- The blastocyst and inner cell mass cells -- Organogenesis -- Mammalian nuclear transplant technology -- Adult and fetal stem cells -- Pluripotent, stem cells -- Neurogenerative diseases -- Tissue systems failures -- The religious, legal, ethical, and scientific debate.
  • Introduction to human factors in medicine -- Human cognition and error -- Situation awareness -- Leadership and teamworking -- Personality and behaviour -- Communication and awareness -- Decision-making -- Fatigue and stress -- Key elements in communication : briefing and debriefing -- Organisational culture -- Guidelines, checklists and protocols.
  • Over the past decade there have been major advances in the field of regenerative medicine with the promise to bring to reality, cures for debilitating diseases such as diabetes, heart failure, and Parkinson's disease. Cellular products from a variety of sources are being evaluated for their ability to replace damaged tissue.Fetal tissues consist of stem cells and progenitor cells which have undergone initial commitment with varying states of differentiation. Stem cells from fetal tissues may also have a greater proliferative potential than their adult counterparts. In addition, fetal derived stem and progenitor cells are immunologically naive and some sources of fetal cells, eg cord blood, have been shown to be capable of crossing greater HLA mismatching resulting in less rejection and decreased immune mediated toxicities. Given the increasing focus on HES and advances in our basic knowledge of regenerative medicine it is an appropriate time to review the biology and use of fetal tissues.Human Fetal Tissue Transplantation is a timely publication that provides details of many aspects of the potential use of fetal tissues for therapeutic applications. As many tissues are wasted on a daily basis it appropriate to raise discussion on how to maximize access to discard tissue and at the same time engage in discussion of the ethics associated with fetal tissue procurement and clinical use.
  • In the nearly 60 years since Watson and Crick proposed the double helical structure of DNA, the molecule of heredity, waves of discoveries have made genetics the most thrilling field in the sciences. The study of genes and genomics today explores all aspects of the life with relevance in the lab, in the doctor's office, in the courtroom and even in social relationships. In this helpful guidebook, one of the most respected and accomplished human geneticists of our time communicates the importance of genes and genomics studies in all aspects of life. With the use of core concepts and the integration of extensive references, this book provides students and professionals alike with the most in-depth view of the current state of the science and its relevance across disciplines. Bridges the gap between basic human genetic understanding and one of the most promising avenues for advances in the diagnosis, prevention and treatment of human disease. Includes the latest information on diagnostic testing, population screening, predicting disease susceptibility, pharmacogenomics and moreExplores ethical, legal, regulatory and economic aspects of genomics in medicine. Integrates historical (classical) genetics approach with the latest discoveries in structural and functional genomics.
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  • As genetic issues play a growing role in health practice and public policy, new knowledge in this field will continue to have significant implications for individuals and society. Written to communicate sound and modern science in an accessible way for professionals and students with various levels of scientific background, this thoroughly revised edition of The Human Genome contributes to creating a genetically literate research and clinical population. With case studies and introductory vignettes which illustrate a wide range of perspectives on complex topics in genetics and updated material on the latest research on disease-specific topics, this book serves as a valuable resource for students and working professionals alike. Full-color illustrations enhance and reinforce key concepts and themes * Chapters include interest boxes that focus on human health and disease, chapter-opening case studies, and concept statements to engage non-specialist readers.
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    Human genome epidemiology: the road map revisited -- Principles of analysis of germline genetics -- The public health genomics enterprise -- Navigating the evolving knowledge of human genetic variation in health and disease -- The global emergence of epidemiological biobanks: opportunities and challenges -- Case-control and cohort studies in the age of genome-wide associations -- The emergence of networks in human genome epidemiology: challenges and opportunities -- Design and analysis issues in genome-wide association studies -- The challenge of assessing complex gene-environment and gene-gene interactions -- STrengthening the REporting of genetic association studies (STREGA)-an extension of the STROBE statement -- Integration of the evidence on gene-disease associations: methods of HuGE reviews -- Genome-wide association studies, field synopses, and the development of the knowledge base on genetic variation and human diseases -- Colorectal cancer -- Childhood leukemias -- Bladder cancer -- Type 2 diabetes -- Osteoporosis -- Preterm birth -- Coronary heart disease -- Schizophrenia -- Mendelian randomization: the contribution of genetic epidemiology to elucidating environmentally modifiable causes of disease -- Evaluation of predictive genetic tests for common diseases: bridging epidemiological, clinical, and public health measures -- The evaluation of genomic applications in practice and prevention (EGAPP) initiative: methods of the EGAPP working group -- Rapid, evidence-based reviews of genetic tests -- Role of social and behavioral research in assessing the utility of genetic information -- Assessing the evidence for clinical utility in newborn screening -- The role of epidemiology in assessing the potential clinical impact of pharmacogenomics -- The human epigenome and cancer -- The use of family history in public health practice: the epidemiologic view -- Cytochrome P450 testing in the treatment of depression -- A rapid-ACCE review of CYP2CP and VKORC1 allele testing to inform warfarin dosing in adults at elevated risk for thrombotic events to avoid serious bleeding -- Hereditary hemochromatosis: population screening for gene mutations.
  • The human growth curve, canalization and catch-up growth / Noël Cameron -- Growth in infancy and childhood: a pediatric approach / Horacio Lejarraga -- Adolescent growth / Roland Hauspie and Mathieu Roelants -- Puberty / Peter T. Ellison and Meredith W. Reiches -- Endocrine control of growth / Ron G. Rosenfeld -- Nutrition and growth / Nicholas G. Norgan, Barry bogin and Noël Cameron -- Genomics, epigenetics and growth / Geert R. Mortier and Wim Vanden Berghe -- The genetic epidemiology of growth and development / Bradford Towne, Ellen W. Demerath and Stefan A. Czerwinski -- Social and economic effects on growth / Richard H. Steckel -- Environmental effects on growth / Lawrence M. Schell, Kristen L. Knutson and Stephen Bailey -- The evolution of human growt / Barry Bogin -- Early environments, developmental plasticity and chronic degenerative disease / Christopher W. Kuzawa -- Leg length, body proportion, health and beauty / Barry Bogin -- Physical activity as a factor in growth and maturation / Robert M. Malina -- Comparative and evolutionary perspectives on human brain growth / William R. Leonard, J. Josh Snodgrass and Marcia L. Robertson -- Saltation and stasis / Michelle Lampl -- Lectures on human growth / Peter C. Hindmarsh -- Body composition during growth and development / Babette S. Zemel -- The measurement of human growth / Noël Cameron -- Assessment of maturation / Noël Cameron -- Growth references and standards / T.J. Cole.
  • Human health handbooks v. 1-, 2012-
  • Preface -- ch. 1. Structure and function of the normal heart -- ch. 2. Valves of the heart -- ch. 3. Pumping action of the heart -- ch. 4. Blood supply of the heart -- ch. 5. The functioning normal heart -- ch. 6. Heart failure -- ch. 7. Hypertensive heart disease -- ch. 8. Coronary heart disease -- ch. 9. The heart valves -- ch. 10. The autonomic or automatic nervous system -- ch. 11. The electrocardiogram -- ch. 12. Cardiac arrhythmias -- ch. 13. Congenital heart disease -- ch. 14. Rheumatic heart disease -- ch. 15. Pregnancy and heart disease -- ch. 16. Pulmonary heart disease -- ch. 17. Imaginary heart disease -- ch. 18. To pace or not to pace -- ch. 19. Medical treatment of heart failure -- ch. 20. Catheterization of the heart and coronary arteriography -- ch. 21. Cardiac surgery -- ch. 22. Heart attack -- ch. 23. Measuring the efficiency of the heart -- ch. 24. Special diagnostic procedures -- Review test -- Answers -- Appendix : Notes for coronary intensive units -- Index.
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  • This new edition, like previous ones, offers a precise description of the anatomy of the human hippocampus based upon neurosurgical progress and the wealth of medical imaging methods available. The first part describes the fine structures of the hippocampus and is illustrated with new original figures. A survey is then provided of current concepts explaining the functions of the hippocampus, and the external and internal hippocampal vascularization is precisely described. The last and main part of the book presents serial sections in coronal, sagittal, and axial planes; each section is accompanied by a drawing to explain the MR 3T images. The new edition is also enriched by several MRI views of major hippocampal diseases. This comprehensive atlas of human hippocampal anatomy will be of interest to all neuroscientists, including neurosurgeons, neuroradiologists, and neurologists.
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  • Development of the First AIDS Drugs: AZT and Other Dideoxynueosides / Robert Yarchoan, Hiroaki Mitsuya -- Part I: Structure and Function of HIV RT. Proviral DNA Synthesis in HIV: Background / Dorota Piekna-Przybylska Ph.D., Robert A. Bambara Ph.D. -- The RNase H Domain: Structure, Function and Mechanism / Marcin Nowotny, Małgorzata Figiel -- Conformational Dynamics of Reverse Transcription / Stuart F. J. LeGrice -- Part II: Mechanism of Action of Approved RT Inhibitors. Nucleoside RT Inhibitors: Structural and Molecular Biology / Gaofei Lu, Antonio J. Acosta-Hoyos, Walter A. Scott -- Nonnucleoside Reverse Transcriptase Inhibitors (NNRTIs) / Kalyan Das Ph.D., Eddy Arnold Ph.D., Stephen H. Hughes Ph.D. -- Part III: Alternative Strategies to Interfere with the Function of HIV RT. Ribonuclease H Inhibitors: Structural and Molecular Biology / Jason W. Rausch -- Targeting Small Molecules and Peptides to the p66-p51 Reverse Transcriptase Interface / Daouda Abba Moussa, Audrey Agopian, Gilles Divita -- Targeting RT Translocation / Gregory L. Beilhartz, Brian J. Scarth, Matthias Götte -- tRNA Primer Sequestration as an Antiviral Strategy / Christopher P. Jones, Karin Musier-Forsyth -- Part IV: HIV Genetic Variability and the Problem of Drug Resistance. HIV Reverse Transcriptase Fidelity, Clade Diversity, and Acquisition of Drug Resistance / Luis Menéndez-Arias -- APOBECs and Their Role in Proviral DNA Synthesis / John S. Albin, Reuben S. Harris -- Role of RNase H Activity in NRTI/NNRTI Drug Resistance / Gilda Tachedjian B.Sc. (Hons), Ph.D., Nicolas Sluis-Cremer B.Sc. (Hons), Ph.D. -- HIV Population Dynamics / Mary Kearney, John Coffin -- Part V: Prevention and Future Approaches. RT Inhibitors as Microbicides / Jan Balzarini.
  • Part 1. Transmission of HIV-1 infection to the infant through breastfeeding -- Breastfeeding and Transmission of HIV-1: Epidemiology and Global Magnitude / Mary Glenn Fowler, Athena P. Kourtis, Jim Aizire, Carolyne Onyango-Makumbi and Marc Bulterys -- Breastfeeding and Transmission of Viruses Other than HIV-1 / Claire L. Townsend, Catherine S. Peckham and Claire Thorne -- Breastfeeding Among HIV-1 Infected Women: Maternal Health Outcomes and Social Repercussions / Elizabeth Stringer and Kate Shearer -- Early Diagnosis of HIV Infection in the Breastfed Infant / Chin-Yih Ou, Susan Fiscus, Dennis Ellenberger, Bharat Parekh and Christine Korhonen, et al. -- Part 2. Mechanisms of HIV-1 transmission through breast milk: Virology -- Virologic Determinants of Breast Milk Transmission of HIV-1 / Susan A. Fiscus and Grace M. Aldrovandi -- HIV-1 Resistance to Antiretroviral Agents: Relevance to Mothers and Infants in the Breastfeeding Setting / Michelle S. McConnell and Paul Palumbo -- Animal Models of HIV Transmission Through Breastfeeding and Pediatric HIV Infection / Koen K. A. Van Rompay and Kartika Jayashankar -- Antiretroviral Pharmacology in Breast Milk / Amanda H. Corbett -- Part 3. Mechanisms of HIV-1 transmission through breast milk: Immunology -- The Immune System of Breast Milk: Antimicrobial and Anti-inflammatory Properties / Philippe Lepage and Philippe Van de Perre -- B Lymphocyte-Derived Humoral Immune Defenses in Breast Milk Transmission of the HIV-1 / Laurent Bélec and Athena P. Kourtis -- Cellular Immunity in Breast Milk: Implications for Postnatal Transmission of HIV-1 to the Infant / Steffanie Sabbaj, Chris C. Ibegbu and Athena P. Kourtis -- Part 4. Prevention of breast milk transmission of HIV-1 -- Antiretroviral Drugs During Breastfeeding for the Prevention of Postnatal Transmission of HIV-1 / Athena P. Kourtis, Isabelle de Vincenzi, Denise J. Jamieson and Marc Bulterys -- Immune Approaches for the Prevention of Breast Milk Transmission of HIV-1 / Barbara Lohman-Payne, Jennifer Slyker and Sarah L. Rowland-Jones -- Non-antiretroviral Approaches to Prevention of Breast Milk Transmission of HIV-1: Exclusive Breastfeeding, Early Weaning, Treatment of Expressed Breast Milk / Jennifer S. Read -- Breast Milk Micronutrients and Mother-to-Child Transmission of HIV-1 / Monal R. Shroff and Eduardo Villamor -- Part 5. Research Implementation and Policy Related to Breastfeeding by HIV-1-Infected Mothers -- Historical Perspective of African-Based Research on HIV-1 Transmission Through Breastfeeding: The Malawi Experience / Taha E. Taha -- Breastfeeding and HIV Infection in China / Christine Korhonen, Liming Wang, Linhong Wang, Serena Fuller and Fang Wang, et al. -- The Role of the President's Emergency Plan for AIDS Relief in Infant and Young Child Feeding Guideline Development and Program Implementation / Michelle R. Adler, Margaret Brewinski, Amie N. Heap and Omotayo Bolu -- HIV-1 and Breastfeeding in the United States / Kristen M. Little, Dale J. Hu and Ken L. Dominguez -- Part 6. DEBATE: Should Women With HIV-1 Infection Breastfeed Their Infants? Balancing the Scientific Evidence, Ethical Issues and Cost-Policy Considerations -- Pendulum Swings in HIV-1 and Infant Feeding Policies: Now Halfway Back / Louise Kuhn and Grace Aldrovandi -- Should Women with HIV-1 Infection Breastfeed Their Infants? It Depends on the Setting / Grace John-Stewart and Ruth Nduati -- Part 7. The Epilogue -- The Future of Breastfeeding in the Face of HIV-1 Infection: Science and Policy / Marc Bulterys and Athena P. Kourtis.
  • 1. Are People Getting Smarter? -- 2. Human IQ and Increasing Intelligence -- 3. Evolution and Increasing Intelligence -- 4. Brain Development and Increasing Intelligence -- 5. Environment and Increasing Intelligence -- 6. Evidence of Physical Plasticity in Humans -- 7. Evidence of Mental Plasticity in Humans -- 8. Evidence of Cognitive Plasticity in Humans -- 9. Impact of Medical Conditions on Human IQ in the United States -- 10. Impact of Medical Conditions on Human IQ Worldwide -- 11. Medical Interventions for Cognitive Impairment -- 12. Increasing IQ in the United States -- 13. Increasing IQ and Social Justice.
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  • Part 1. Historical and Socio-Cultural Contexts in Medical Research / British Responses to Nazi Medical War Crimes / Fiona McClenaghan -- History and its Relevance in the Development and Teaching of Research Ethics / Rael D. Strous -- Human Embryo Research and Islamic Bioethics: A View from Iran / Mansooreh Saniei -- From Farming to Pharming: Transcending of Bodily Existence as a Question of Medical Ethics in an Intercultural Context / Axel Siegemund -- Introduction / Jan Schildmann, Verena Sandow, Oliver Rauprich and Jochen Vollmann -- Part 2. Considerations on Ethical and Legal Regulations for Medical Research / Rethinking the Therapeutic Obligation in Clinical Research / Nunziata Comoretto -- Biomedical Research in Developing Countries and International Human Rights Law / Ilja R. Pavone -- Research Involving Human Subjects and Human Biological Material from a European Patent Law Perspective. Autonomy, Commodification, Patentability / Tomasz Zimny -- The Development and Validation of a Guide for Peruvian Research Ethics Committees to Assist in the Review of Ethical-Scientific Aspects of Clinical Trials / Susy Olave Quispe, Duilio Fuentes Delgado, Gabriela Minaya Martínez, Rosa Surco Ibarra and Martín Yagui Moscoso, et al. -- Part 3. Conflicts in Medical Research / Conflicts of Interest in Medical Research: What can Ethics Contribute? / Verena Sandow, Jan Schildmann and Jochen Vollmann -- Research Ethics in Genomics Research: Feedback of Individual Genetic Data to Research Participants / Annelien L. Bredenoord and Johannes J. M. van Delden -- Regulating "Higher Risk, No Direct Benefit" Studies with Children: Challenging the US Federal Regulations / Anna E. Westra, Jan M. Wit, Rám N. Sukhai and Inez D. de Beaufort -- Part 4. New Developments in Medical Research and Ethical Implications / A Paradigm Change in Research Ethics / Rieke van der Graaf and Johannes J. M. van Delden -- Translation of Cancer Molecular Biomarkers: Ethical and Epistemological Issues / Flavio D'Abramo and Cecilia Guastadisegni -- Rethinking the Ethics of Human Biomedical Non-Interventional Research / Kristi L{tilde}ouk.
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    Nucleic acid structure and gene expression -- Chromosome structure and function -- Genes in pedigrees and populations -- Cells and cell-cell communication -- Principles of development -- Amplifying DNA : cell-based DNA cloning and PCR -- Nucleic acid hybridization : principles and applications -- Analyzing the structure and expression of genes and genomes -- Organization of the human genome -- Model organisms, comparative genomics, and evolution -- Human gene expression -- Studying gene function in the post-genome era -- Human genetic variability and its consequences -- Genetic mapping of mendelian characters -- Mapping genes conferring susceptibility to complex diseases -- Identifying human disease genes and susceptibility factors -- Cancer genetics -- Genetic testing of individuals -- Pharmacogenetics, personalized medicine and population screening -- New approaches to therapy -- Genetic manipulation of animals for modeling disease and investigating gene function -- Genetic approaches to treating disease.
  • 1. Understanding human motion: a historic review / Reinhard Klette and Garry Tee -- pt. I. 2D tracking: 2. The role of manifold learning in human motion analysis / Ahmed Elgammal and Chan-Su Lee ; 3. Recognition of action as a Bayesian parameter estimation problem over time / Volker Krüger ; 4. The William Harvey code: mathematical analysis of optical flow computation for cardiac motion / Yusuke Kameda and Atsushi Imiya ; 5. Detection and tracking of humans in single view sequences using 2D articulated model / Filip Korč and Václav Hlaváč -- pt. II. Learning: 6. Combining discrete and continuous 3D trackers / Gabriel Tsechpenakis, Dimitris Metaxas, and Carol Neidle ; 7. Graphical models for human motion modelling / Kooksang Moon and Vladimir Pavlović ; 8. 3D human motion analysis in monocular video: techniques and challenges / Christian Sminchisescu ; 9. Spatially and temporally segmenting movement to recognize actions / Richard Green ; 10. Topologically constrained idometric embedding / Guy Rosman, Alexander M. Bronstein, Michael M. Bronstein, and Ron Kimmel -- pt. III. 2D-3D tracking: 11. Contours, optic flow, and prior knowledge: cues for capturing 3D human motion in videos / Thomas Brox, Bodo Rosenhahn, and Daniel Cremers ; 12. Tracking clothed people / Bodo Rosenhahn, Uwe G. Kersting, Katie Powell, T. Brox, and Hans-Peter Seidel ; 13. An introduction to interacting simulated annealing / Jürgen Gall, Bodo Rosenhahn, and Hans-Peter Seidel ; 14. Motion capture for interaction environments / Daniel Grest and Reinhard Koch ; 15. Markerless motion capture for biomechanical applications / Lars Mündermann, Stefano Corazza, and Thomas P. Andriacchi -- pt. IV. Biomechanics and applications: 16. Qualitative and quantitative aspects of movement: the discrepancy between clinical gait analysis and activities of daily life / Dieter Rosenbaum and Mirko Brandes ; 17. Optimization of human motion exemplified with handbiking by means of motion analysis and musculoskeletal models / Harald Böhm and Christian Krämer ; 18. Imitation learning and transferring of human movement and hand grasping to adapt to environment changes / Stephan Al-Zubi and Gerald Sommer ; 19. Accurate and model-free pose estimation of crash test dummies / Stefan K. Gehrig, Hernán Badino, and Jürgen Gall -- pt. V. Modelling and animation: 20. A relational approach to content-based analysis of motion capture data / Meinard Müller and Tido Röder ; 21. The representation of rigid body motions in the conformal model of geometric algebra / Leo Dorst ; 22. Video-based capturing and rendering of people / Christian Theobalt, Marcus Magnor, and Hans-Peter Seidel ; 23. Interacting deformable objects / Matthias Teschner, Bruno Heidelberger, and Matthias Müller-Fischer ; 24. From performance theory to character animation tools / Michael Neff and Eugene Fiume.
  • 2012 ClinicalKey
  • Hidemi Ishida : 40 years of footprints in Japanese primatology and paleoanthropology / Masato Nakatsukasa ... [et al.] -- Seven decades of East African Miocene anthropoid studies / Russell H. Tuttle -- Evolution of the vertebral column in Miocene hominoids and Plio-Pleistocene hominids / Dominique Gommery -- Terrestriality in a middle Miocene context : Victoriapithecus from Maboko, Kenya / Kathleen T. Blue, Monte L. McCrossin and Brenda R. Benefit -- Late Cenozoic mammalian biostratigraphy and faunal change : paleoenvironments of hominoid evolution and dispersal / Hideo Nakaya and Hiroshi Tsujikawa -- The ages and geological backgrounds of Miocene hominoids Nacholapithecus, Samburupithecus, and Orrorin from Kenya / Yoshihiro Sawada ... [et al.] -- Patterns of vertical climbing in primates / Yoshihiko Nakano, Eishi Hirasaki and Hiroo Kumakura -- Functional morphology of the midcarpal joint in knuckle-walkers and terrestrial quadrupeds / Brian G. Richmond -- Morphological adaptation of rat femora to different mechanical environments / Akiyoshi Matsumura, Morihiko Okada and Yutaka Takahashi -- A hallmark of humankind : the gluteus maximus muscle : its form, action, and function / Françoise K. Jouffroy and Monique F. Médina -- Primates trained for bipedal locomotion as a model for studying the evolution of bipedal locomotion / Eishi Hirasaki, Naomichi Ogihara and Masato Nakatsukasa -- Locomotor energetics in nonhuman primates : a review of recent studies on bipedal performing macaques / Masato Nakatsukasa, Eishi Hirasaki and Naomichi Ogihara -- Computer simulation of bipedal locomotion : toward elucidating correlations among musculoskeletal morphology, energetics, and the origin of bipedalism / Naomichi Ogihara and Nobutoshi Yamazaki -- Paleoenvironments, paleoecology, adaptations and the origins of bipedalism in Hominidae / Martin Pickford -- Arboreal origin of bipedalism / Brigitte Senut -- Neontological perspectives on East African middle and late Miocene Anthropoidea / Russell H. Tuttle -- The prehominid locomotion reflected : energetics, muscles, and generalized bipeds / Morihiko Okada -- Evolution of the social structure of hominoids : reconsideration of food distribution and the estrus sex ratio / Takeshi Furuichi -- Are human beings apes, or are apes people too? / Russell H. Tuttle -- Current thoughts on terrestrialization in African apes and the origin of human bipedalism / Hidemi Ishida.
  • Human Papilloma viruses 2002.
  • "Human papillomavirus (HPV) infection transcends multiple fields of science and medicine. The management of HPV-related disease is demanding and often requires a persistent multimodal approach involving various medical disciplines. In this volume, experts present a comprehensive view of HPV research with an emphasis on clinical presentations, diagnosis, management and vaccine development. The state of the art in molecular biology is provided in addition to discussions on clinical morphology and the utility of dermatoscopy in identifying HPV disease. In a multidisciplinary approach to dermatological, plastic and reconstructive, gynecological, otolaryngological and colorectal management, different treatment strategies are highlighted"--Publisher's description.
  • Human papillomavirus vaccines / Eduardo L. Franco -- Pathobiology and immunology of human papillomavirus / Margaret Stanley -- Overview of clinical evidence : the quadrivalent vaccine Gardasil / Suzanne M Garland -- Overview of clinical evidence : Cervarix -- Tino F. Schwarz -- HPV vaccines : public health and clinical guidelines / F. Xavier Bosch -- Perspectives for prophylactic and therapeutic vaccination for HPV-induced lesions / Shreya Kanodia & W. Martin Kast.
  • 1. Human Papillomavirus (HPV) infection -- 2. Studies of cancer in humans -- 3. Studies of animal papillomaviruses -- 4. Molecular mchanisms of HPV-induced carcinogenesis -- 5. Summary of data reported and evaluation -- 6. References
  • Analysis of HPV DNA replication using transient transfection and cell-free assays / Bing Yuan Lin, Thomas R. Broker, and Louise T. Chow -- Detection and quantitation of HPV DNA replication by southern blotting and real-time PCR / Iain M. Morgan and Ewan R. Taylor -- Analysis of E7/RB associations / Sandra Caldeira, Wen Dong, and Massimo Tommasino -- Transformation assays for HPV oncoproteins / Paola Massimi and Lawrence Banks -- Analysis of adeno-associated virus and hpv interaction / Paul L. Hermonat ... [et al.] -- In vitro assays of substrate degradation induced by high-risk HPV E6 oncoproteins / Miranda Thomas and Lawrence Banks -- Measuring the induction or inhibition of apoptosis by HPV proteins / Anna M. Kowalczyk ... [et al.] -- Codon optimization of papillomavirus genes / Martin Muller -- Generation of HPV pseudovirions using transfection and their use in neutralization assays / Christopher B. Buck ... [et al.] -- Generation and application of HPV pseudovirions using vaccinia virus / Martin Sapp and Hans-Christoph Selinka. Differentiation of HPV-containing cells using organotypic "raft" culture or methylcellulose / Regina Wilson and Laimonis A. Laimins -- Propagation of infectious, high-risk HPV in organotypic "raft" culture / Margaret E. McLaughlin-Drubin and Craig Meyers -- Retrovirus-mediated gene transfer to analyze HPV gene regulation and protein functions in organotypic "raft" cultures / N. Sanjib Banerjee, Louise T. Chow, and Thomas R. Broker -- The HPV xenograft severe combined immunodeficiency (scid) mouse model / William Bonner -- The cottontail rabbit papillomavirus model of high-risk HPV-induced disease / Janet L. Brandsma -- Studying the HPV lifecycle in 3A trophoblasts and resulting pathophysiology / Yong Liu, Hong You, and Paul L. Hermonat -- Replication and encapsidation of papillomaviruses in saccharomyces cerevisiae / Peter C. Angeletti -- Analysis of the regulation of viral transcription / Bernd Gloss, Mina Kalantari, and Hans-Ulrich Bernard -- Analysis of HPV transcripts by RPA / Jason M. Bodily and Craig Meyers -- Analysis of regulatory motifs within HPV transcripts / Sarah A. Cumming and Sheila V. Graham -- Detection of HPV transcripts by nested RT-PCR / Christine Mant, Barbara Kell, and John Cason -- Identification of new papillomavirus types / Ethel-Michele de Villiers, Corinna Whitley, and Karin Gunst -- Identification of HPV variants / John Cason, Jon Bible, and Christine Mant -- Histochemical analysis of cutaneous HPV-associated lesions / Kiyofumi Egawa -- Histochemical analysis of cervical intraepithelial neoplasia / Michael Babawale ... [et al.] -- Detection of papillomavirus proteins and DNA in paraffin-embedded tissue sections / Woei Ling Peh and John Doorbar -- Detection and quantitation of HPV gene expression using real-time PCR / Rashmi Seth ... [et al.] -- Analysis of P16INK4A and integrated genomes as progression markers / Svetlana Vinokurova, Nicolas Wentzensen, and Magnus von Knebel Doeberitz -- Use of biomarkers in the evaluation of CIN grade and progression of early CIN / Jan P.A. Baak and Arnold-Jan Kruse -- HPV DNA detection and typing in cervical scrapes / Peter J. F. Snijders ... [et al.] -- HPV DNA detection and typing in inapparent cutaneous infections and premalignant lesions / Maurits de Koning ... [et al.] -- Establishing HPV-containing keratinocyte cell lines from tissue biopsies / Margaret Anne Stanley -- Using an immortalized cell line to study the HPV lifecycle in organotypic "raft" cultures / Paul F. Lambert ... [et al.] --
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    Symbiosis and parasitism -- Parasite-host interactions -- General characteristics of the protozoa -- Visceral protozoa I: amoebae and ciliates -- Visceral protozoa II: flagellates -- Blood and tissue protozoa I: hemoflagellates -- Blood and tissue protozoa II: human malaria -- Blood and tissue protozoa III: other apicomplexans -- General characteristics of the trematoda -- Visceral flukes -- Blood flukes -- General characteristics of the cestoidea -- Intestinal tapeworms -- Extraintestinal tapeworms -- General characteristics of the nematoda -- Intestinal nematodes -- Blood and tissue nematodes -- Arthropods as vectors.
  • The NASA Human Performance Modeling (HPM) project: goals, approach, and overview / David C. Foyle and Becky L. Hooey -- Using human performance modeling in aviation / David C. Foyle and Becky L. Hooey -- Aviation safety studies: taxi navigation errors and synthetic vision system operations / Becky L. Hooey and David C. Foyle -- Overview of human performance modeling tools / Kenneth Leiden ... [et al.] -- An ACT-R approach to closing the loop on computational cognitive modeling: describing the dynamics of interactive decision making and attention allocation / Michael D. Byrne, Alex Kirlik, and Michael D. Fleetwood -- Modeling pilot performance with an integrated task network and cognitive architecture approach / Christian Lebiere ...[et al.] -- AIR MIDAS: a closed-loop model framework / Kevin M. Corker ... [et al.] -- D-OMAR: an architecture for modeling multi-task behaviors / Stephen E. Deutsch and Richard W. Pew -- Attention-situation awareness (A-SA) model of pilot error / Christopher D. Wickens ... [et al.] -- A cross-model comparison / Kenneth Leiden and Brad Best -- Human performance modeling: "a virtual roundtable discussion" / David C. Foyle ... [et al.] -- Advancing the state-of-the-art of human performance models to improve aviation safety / Becky L. Hooey and David C. Foyle.
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    Medicine and authority -- The Medical uses of nonsense -- A Hostile environment -- Death comes alive -- Pleasure in revolt -- Monsters and artists -- Abstracting desire -- What abjection means.
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  • Cognitive neuroscience of sleep / Gina R. Poe, Christine M. Walsh, Theresa E. Bjorness -- Measurement of sleep / Bob Kemp -- Measurement of cognition in studies of sleep deprivation / Paul Whitney, John M. Hinson -- Sleep, memory and emotion / Matthew P. Walker -- How treatment affects cognitive deficits in patients with sleep disorders: methodological issues and results / Stephany Fulda, Hartmut Schulz -- Total sleep deprivation, chronic sleep restriction and sleep disruption / Amy C. Reynolds, Siobhan Banks -- Effects of sleep deprivation on cognition / William D.S. Killgore -- Circadian rhythms and cognition / Jim Waterhouse -- The effects of napping on cognitive functioning / Nicole Lovato, Leon Lack -- Sleep, intelligence and cognition in a developmental context: differentiation between traits and state-dependent aspects / Anja Geiger, Peter Achermann, Oskar G. Jenni -- Do sleep complaints contribute to age-related cognitive decline? / Ellemarije Altena, Jennifer R. Ramautar, Ysbrand D. Van Der Werf, Eus J.W. Van Someren.
  • There is a critical, bidirectional relationship between sleep and cognition, yet the literature in this area is scattered and it is surprisingly difficult to find a comprehensive overview of the basic principles, latest discoveries, and outstanding challenges. This issue of Progress in Brain Research is spilt over 2 volumes bringing together cutting-edge research on the topic in the basic, clinical and applied sciences. The 2 volumes review current knowledge and understanding, provide a starting point for researchers and practitioners entering the field, and build a platform for further research.
  • This manual is a comprehensive compilation of "methods that work" for deriving, characterizing, and differentiating hPSCs, written by the researchers who developed and tested the methods and use them every day in their laboratories. The manual is much more than a collection of recipes; it is intended to spark the interest of scientists in areas of stem cell biology that they may not have considered to be important to their work. The second edition of the Human Stem Cell Manual is an extraordinary laboratory guide for both experienced stem cell researchers and those just beginning to use stem cells in their work. Offers a comprehensive guide for medical and biology researchers who want to use stem cells for basic research, disease modeling, drug development, and cell therapy applications.Provides a cohesive global view of the current state of stem cell research, with chapters written by pioneering stem cell researchers in Asia, Europe, and North America.Includes new chapters devoted to recently developed methods, such as iPSC technology, written by the scientists who made these breakthroughs.
  • 'An engaging, compelling and disturbing confrontation with evil...abook that will be transformative in its call for individual and collective moral responsibility." - Michael A. Grodin, M.D., Professor and Director, Project on Medicine andtheHolocaust, Elie Wiesel Center for Judaic Studies, Boston University Human Subjects Research after the Holocaust challenges you to confront the misguided medical ethics of the Third Reich personally, and to apply the lessons learned to contemporary human subjects research. While it is comforting to believe that Nazi physicians, nurses, and bioscientists were either incompetent, mad, or few in number, they were, in fact, the best in the world at the time, and the vast majority participated in the government program of 'applied biology.' They were not coerced to behave as they did-they enthusiastically exploited widely accepted eugenic theories to design horrendous medical experiments, gas chambers and euthanasia programs, which ultimately led to mass murder in the concentration camps. Americans provided financial support for their research, modeled their medical education and research after the Germans, and continued to perform unethical human subjects research even after the Nuremberg Doctors' Trial. The German Medical Association apologized in 2012 for the behavior of its physicians during the Third Reich. By examining the medical crimes of human subjects researchers during the Third Reich, you will naturally examine your own behavior and that of your colleagues, and perhaps ask yourself "If the best physicians and bioscientists of the early 20th century could do evil while believing they were doing good, can I be certain that I will never do the same?" · Presents relatively unknown aspects of human subjects research during the Third Reich · Reveals surprising relationships between German and American human subjects research · Dispels myths about Nazi human subjects research · Compels introspection and self-examination by today's medical and research practitioners · Addresses contemporary bioethical issues affecting vulnerable populations · Brings together experts in the history of medicine during the Third Reich and thoughtful new voices
  • In this important reference work, Zeliger catalogs the known effects of chemical mixtures on the human body and also proposes a framework for understanding and predicting their actions in terms of lipophile (fat soluble) / hydrophile (water soluble) interactions. The author's focus is on illnesses that ensue following exposures to mixtures of chemicals that cannot be attributed to any one component of the mixture. In the first part the mechanisms of chemical absorption at a molecular and macromolecular level are explained, as well as the body's methods of defending itself against xenobiotic intrusion. Part II examines the sources of the chemicals discusssed, looking at air and water pollution, food additives, pharmaceuticals, etc. Part III, which includes numerous case studies, examines specific effects of particular mixtures on particular body systems and organs and presents a theoretical framework for predicting what the effects of uncharacterized mixtures might be. Part IV covers regulatory requirements and the need to adjust recommended exposure levels for products containing mixtures. It also contains recommendations on how to limit exposure to mixtures in the products we use and on how to limit release of mixtures into the environment. Providing brief summaries of each mixture and its effects, Zeliger provides a comprehensive reference, a jumping off point for professionals (with extensive chapter bibliographies) and an introduction to the topic for those studying traditional toxicology. Addressing many inadequately understood illnesses and conditions such as asthma, infertility and cancer, it will also be of interest to health professionals, environmental scientists and lawyers. Presents a theoretical framework for predicting the effects of chemical mixtures for which no specific data exists (this predictive aspect is important due to the vast number of different potential chemical combinations - far too many to comprehensively catalog). A quick and convenient source of hard to come by data on the rapidly developing field of chemical mixtures, for groups including chemists and engineers, toxicologists, health professionals and environmental scientists. . New and updated material comprises over 30% of this timely new edition, which includes the latest research data alongside an expanded introduction to the science and art of predicting the toxicological properties of chemical mixtures.
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    Virology : how it all began -- General properties of viruses -- Viral replication and genetics -- How viruses cause disease -- Resistance to virus infections -- Viruses and cancer in humans -- Viruses and the community -- Upper respiratory tract and eye infections due to adenoviruses, coronaviruses (including SARS CoV), and rhinoviruses -- Childhood infections caused by paramyxoviruses -- Orthomyxoviruses and influenza -- Gastroenteritis viruses -- Rubella : postnatal infections -- Parvoviruses -- Poxviruses -- Papovaviruses -- Poliomyelitis and other picornavirus infections -- The herpesviruses : general properties -- The alphaherpesviruses : herpes simplex and varicella-zoster -- The betaherpesviruses : cytomegalovirus and human herpesviruses 6 and 7 -- The gammaherpesviruses : Epstein-barr virus and Kaposl's sarcoma-associated herpesvirus -- Introduction to the hepatitis viruses -- The blood-borne hepatitis viruses B and delta -- The enteric hepatitis viruses A and E -- The blood-borne hepatitis flaviviruses -- Retroviruses and AIDS -- Lyssavirus and rabies -- Arthropod-borne viruses -- Exotic and dangerous infections : filoviruses, arenaviruses, and hantaviruses -- Prions and the spongiform encephalopathies -- Viral diseases of the central nervous system -- Intrauterine and perinatal infections -- Viral infections in patients with defective immunity -- Respiratory infections -- Sexually transmitted viral infections -- Resurgent and emergent viral infections -- The laboratory diagnosis of viral infections -- Control of viral diseases by immunization -- Antiviral chemotherapy.
  • Human viruses in water 2007
  • pt. 1. Humans in HCI -- pt. 2. Computers in HCI -- pt. 3. Designing human-computer interactions -- pt. 4. Application/domain specific design -- pt. 5. Designing for diversity -- pt. 6. The development process.
  • Humanized mice 2008
    Basic Concept of Development and Practical Application of Animal Models for Human Diseases / Tatsuji Nomura, N. Tamaoki, A. Takakura and H. Suemizu, p. 25-51-- Humanized SCID Mouse Models for Biomedical Research / T. Pearson, D. L. Greiner and L. D. Shultz, p. 53-76 -- NOD/Shi-scid IL2rγnull (NOG) Mice More Appropriate for Humanized Mouse Models / M. Ito, K. Kobayashi and T. Nakahata, p. 77-86 -- Humanizing Bone Marrow in Immune-Deficient Mice / K. Ando, Y. Muguruma and T. Yahata, p. 87-94 -- The Differentiative and Regenerative Properties of Human Hematopoietic Stem/Progenitor cells in NOD-SCID/IL2rγnull Mice / F. Ishikawa, Y. Saito, S. Yoshida, M. Harada and L. D. Shultz, p. 95-107 -- Antigen-Specific Antibody Production of Human B Cells in NOG Mice Reconstituted with the Human Immune System / M. Ito, M. Shiina, Y. Saito, Y. Tokuda and Y. Kametani, et al., p. 109-124 -- Humanized Immune System (HIS) Mice as a Tool to Study Human NK Cell Development / N. D. Huntington and J. P. Di Santo, p. 125-131 -- Human T Cell Development and HIV Infection in Human Hemato-Lymphoid System Mice / S. Baenziger, P. Ziegler, L. Mazzucchelli, L. Bronz and R. F. Speck, et al., p. 133-148 -- Humanized Mice for Human Retrovirus Infection / Y. Koyanagi, Y. Tanaka, M. Ito and N. Yamamoto, p. 149-165 -- Functional and Phenotypic Characterization of the Humanized BLT Mouse Model / A. K. Wege, M. W. Melkus, P. W. Denton, J. D. Estes and J. V. Garcia, p. 167-177 -- Novel Metastasis Models of Human Cancer in NOG Mice / M. Nakamura and H. Suemizu, p. 179-196 -- In Vivo Imaging in Humanized Mice / H. Masuda, H. J. Okano, T. Maruyama, Y. Yoshimura and H. Okano, et al.
  • Inadequate humidification of inspired gases can cause a variety of serious problems, and humidification has accordingly become an important aspect of modern intensive care medicine. The array of available devices is now formidable, and appropriate advice on their use is essential. Accordingly, this book is designed to serve as a practical guide for clinicians, providing information on the theoretical background of humidification, the equipment, and its optimal application.The book starts by examining the physiological basis of humidification. Current devices are then discussed, with careful attention to factors influencing their performance and methods to evaluate their effectiveness. The two scenarios of mechanical and non-mechanical ventilation are considered, and the issue of ventilator-associated pneumonia is addressed in detail. Further chapters focus on such topics as humidification following tracheostomy, humidification of the artificial airway during secretion management, measurement of inspired gas temperature in the ventilated neonate, and humidification in the home care setting.This unique monograph on the current techniques of humidification and their indications has been written by internationally acclaimed experts and will prove of great value to practitioners.
  • Clinical relevance of preformed HLA donor-specific antibodies in kidney transplantation / C. Lefaucheur ... [et al.] -- Therapeutic strategies in management of the highly HLA-sensitized and ABO-incompatible transplant recipients / S.C. Jordan ... [et al.] -- Posttransplant immunosuppression in highly sensitized patients / E. Akalin -- Rapid accomodation of an A1 renal allograft after preconditioning for ABO-incompatible transplantation / G. Allen ... [et al.] -- ABO-incompatible kidney transplantation with antigen-specific immunoadsorption and rituximab / M. Geyer ... [et al.] -- Evaluation of two different preconditioning regimens for ABO-incompatible living kidney donor transplantation : a comparison of splenectomy vs. rituximab-treated non-splenectomy preconditioning regimens / K. Tanabe ... [et al.]. Pathology of chronic humoral rejection / R.B. Colvin -- De novo anti-HLA antibody responses after renal transplantation : detection and clinical impact / M. Seveso ... [et al.] -- The emerging issue of MICA antibodies : antibodies to MICA and other antigens of endothelial cells / P. Stastny ... [et al.] -- Development of non-donor-specific HLA antibodies after kidney transplantation : frequency and clinical implications / D. Briggs, D. Zehnder, R.M. Higgins -- Control of anti-donor antibody production post-transplantation : conventional and novel immunosuppressive therapies / J.M. Cruzado, O. Bestard, J.M. Grinyó -- Non-HLA antibodies post-transplantation: clinical relevance and treatment in solid organ transplantation / D. Dragun, B. Hegner.
  • Summer 2014 yielded good news for the Summer Nutrition Programs and for low-income children. Last summer marked the largest increase in children eating summer meals since July 1993, the third year of growth in the programs. During July 2014, the Summer Nutrition Programs served nearly 3.2 million children, an increase of 215,000 (7.3 percent) from 2013.
  • pt. 1. Clinical practice in the tropics -- pt. 2. Viral diseases -- pt. 3. Bacterial infections -- pt. 4. The mycoses -- pt. 5. Protozoal infections -- pt. 6. Helminthic infections -- pt. 7. Poisonous and toxic plants and animals -- pt. 8. Nutritional problems and deficiency diseases -- pt. 9. Vector transmission of diseases and zoonoses -- pt. 10. The sick returning traveler -- pt. 11. Laboratory diagnosis of parasitic diseases -- pt. 12. Drugs used in tropical medicine.
  • Hurst's Imaging cases 2014-
    module 1. Angiography CT scans : normal coronary anatomy / Milind Desai, Rahul Renapurkar -- module 2. Angiography CT scans : coronary artery disease and coronary anomalies / Milind Desai, Rahul Renapurkar -- module 3. Angiography CT scans : aortic and pericardial disease / Milind Desai, Rahul Renapurkar -- module 4. Coronary and peripheral angiography and intervention / Duane S. Pinto, Ali Mahajerin -- module 5. Cardiac MRI / Zelmira Curillova -- module 6. Arrhythmia EKGs and intracardiacs / Ashok J. Shah, Ranjan K. Thakur -- module 7. Transthoracic echocardiograms / Jayashri Aragam, Santanu Biswas.
  • Print Material
  • Hurst's The Heart. 13th ed. 2011 (13th ed).
    "It has been 44 years since the publication of the first edition of Hurst's the Heart, the first multidisciplinary and comprehensive textbook on cardiovascular disease. Through 13 editions, The Heart has always represented a cornerstone of current scholarship in the discipline. Cardiologists, internists, and trainees from around the world have relied on its authority, breadth of coverage, and clinical relevance to keep up to date on advances in the field and to help optimize patient care. The 13th edition of The Heart continues and actually exceeds this standard-setting tradition with 19 new chapters and 59 new authors from around the globe who are experts in their respective content areas"--Preface.
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  • Doctor and patient : general principles of history taking / Michael Glynn -- General patient examination and differential diagnosis / William Drake -- Ethical considerations / William Drake -- Women / Alan Naftalin -- Children and adolescents / Anna Riddell -- Older people / Adam Feather -- Psychiatric assessment / Ruth E. Taylor -- Patients presenting as emergencies / Robert Ghosh -- Patients in pain / Jayne Gallagher and Serge Nikolic -- Respiratory system / F. Runa Ali and John Moore-Gillon -- Cardiovascular system / Adam D. Timmis and Andrew Archbold -- Gastrointestinal system / Michael Glynn -- Locomotor system / David P. D'Cruz -- Nervous system / Rodney W.H. Walker -- Skin, nails and hair / Rino Cerio -- Endocrine disorders / William Drake and John Monson -- Diabetic and other metabolic disorders / Tahseen A. Chowdhury -- Kidneys and urinary tract / Raj Thuraisingham -- Eyes / Andrew Coombes -- Ear, nose, and throat / Michael J. Wareing -- Sexually transmitted infections / Beng T. Goh.
  • Association between cancer and "acid mucopolysaccharides" : an old concept comes of age, finally -- Hyaluronan-CD44 interactions and chemoresistance in cancer cells -- Growth factor regulation of hyaluronan deposition in malignancies -- Hyaluronan binding protein 1 (HABP1/p32/gClqR) : a new perspective in tumor development -- CD44 meets Merlin and Ezrin : their interplay mediates the pro-tumor activity of CD44 and tumor-suppressing effect of Merlin -- Hyaluronan-mediated CD44 interaction with receptor and non-receptor kinases promotes oncogenic signaling, cytoskeleton activation, and tumor progression -- Adhesion and penetration : two sides of CD44 signal transduction cascades in the context of cancer cell metastasis -- Involvement of CD44, a molecule with a thousand faces, in cancer dissemination -- RHAMM/HMMR : an itinerant and multifunctional hyaluronan binding protein that modifies CD44 signaling and mitotic spindle formation -- Altered hyaluronan biosynthesis in cancer progression -- Hyaluronidase : both a tumor promoter and suppressor -- The hyaluronidases in cancer biology -- Hyaluronan fragments : informational polymers commandeered by cancers -- Hyaluronan in human tumors : importance of stromal and cancer cell-associated hyaluronan -- The oncofetal paradigm revisited : MSF and HA as contextual drivers of cancer progression -- Hyaluronan synthesis and turnover in prostate cancer -- Role of hyaluronan in melanoma progression -- Role of hyaluronan metabolism in the initiation, invasion, and metastasis of breast cancer -- Clinical use of hyaluronidase in combination cancer chemotherapy : a historic perspective -- Exploring the hyaluronan:CD44 interaction for cancer therapy -- Hyaluronidase-2 and its role as a cell-entry receptor for sheep retroviruses that cause contagious respiratory tract cancers.
  • Ch. 1. Emerging roles for hyaluronidase in cancer metastasis and therapy -- Ch. 2. Targeting hyaluronic acid family for cancer chemoprevention and therapy -- Ch. 3. Aberrant posttranscriptional processing of hyaluronan synthase 1 in malignant transformation and tumor progression -- Ch. 4. Hyaluronan synthases posttranslational regulation in cancer -- Ch.4. Hyaluronan synthases posttranslational regulation in cancer -- Ch. 5. Hyaluronan-coated extraellular vesicles, a novel link between hyaluronan and cancer -- Ch.6.Hyaluronan in the healthy and malignant hematopoietic microenvironment -- Ch. 7. Hyaluronan regulation of endothelial barrier function in cancer -- Ch. 8. HAS2 and CD44 in breast tumorigenesis -- Ch. 9. CD44 is a multidomain signaling platform that integrates extracellular matrix cues with growth factor and cytokine signals -- Ch. 10. Hyaluronan-CD44 interaction promotes oncogenic signaling, microRNA functions, chemoresistance, and radiation resistance in cancer stem cells leading to tumor progression -- Ch. 11. Advances and advantages of nanomedicine in the pharmacological targeting of hyaluronan-CD44 interactions and signaling in cancer -- Ch.12. Hyaluronan/RHAMM interactions in mesenchymal tumor pathogenesis: role of growth factors -- Ch. 13. CD147: regulator of hyaluronan signaling in invasiveness and chemoresistance -- Index.
  • "Hydatid disease, a zoonotic infection caused by a tapeworm of the genus Echinococcus, has been encountered in various organs in humans. In spite of all the advances in imaging techniques and therapeutic methods, hydatidosis of the central nervous system is still a life-threatening condition in infested areas of the world. Geographical regions affected include the Middle East, Mediterranean countries, South America, Central and Eastern Europe, South Africa, India, and Australia. This is the first comprehensive reference book on hydatidosis of the central nervous system. It is written and edited by leading international authorities from infested areas and provides an in-depth review of diagnosis and management of the disease. Clinical and neuroradiological findings are extensively documented with the aid of numerous original photographs, and the role of surgical intervention and chemotherapy is carefully appraised. In addition to the provision of detailed current evidence, future avenues and innovative therapeutic philosophies are discussed. This book will serve as an ideal source of up-to-date information for all with an interest in this debilitating disease."--Publisher's website.
  • I Importance of the Work of Professor Marmarou -- 5<sup>th</sup> International Hydrocephalus Workshop, Crete, Greece, May 20-23, 2010: Themes and Highlights -- Modelling of CSF Dynamics -- Legacy of Professor Anthony Marmarou -- II Importance of Data, Especially from Randomized Controlled Trials -- Ethical Considerations in Hydrocephalus Research that Involves Children and Adults -- Conservative versus Surgical Management of Idiopathic Normal Pressure Hydrocephalus: a prospective randomized controlled double blind trial; study protocol -- Ten Years of Clinical Experience in the Use of Fixed-Pressure vs. Programmable Valves: A Retrospective Study of 159 Patients -- III Magnetic Resonance Imaging as a Powerful Tool -- Changes of fractional anisotropy (FA) and apparent diffusion coefficient (ADC) in patients with idiopathic normal pressure hydrocephalus -- Virchow-Robin spaces in idiopathic normal pressure hydrocephalus: A surrogate imaging marker for co-existing microvascular disease? -- Quantification of normal CSF flow through the aqueduct using PC-Cine MRI at 3T -- Correlation between tap test and CSF aqueductal stroke volume in idiopathic normal pressure hydrocephalus -- IV Basic Science: The Aquaporin Story -- Overview of the CSF dual outflow system -- Hydrocephalus and aquaporins. The role of aquaporin-1 -- Hydrocephalus and aquaporins. The role of aquaporin-4 -- Acetazolamide-induced Decrease of Apical Fluid Flow in Choroid Plexus is Associated with Nonessential Changes in Aquaporin-1 Expression -- V Experimental Studies: Hydrocephalus -- Physical phantom of cranio-spinal hydrodynamics -- Programmable Shunt Assistant tested in Cambridge Shunt Evaluation Laboratory -- Simulation of existing and future electromechanical shunt valves in combination with a model for brain fluid dynamics -- Examination of deposits in Cerebrospinal Fluid shunt valves using Scanning Electron Microscopy -- Microstructural alterations of silicone catheters in an animal experiment: histopathology and SEM-findings -- Expression analysis of High Mobility Group Box-1 Protein (HMGB-1) in the cerebral cortex , hippocampus , cerebellum of the congenital hydrocephalus rat (H-Tx rat) -- Brain Localization of Leucine-Rich SaB2 Glycoprotein and its Role -- Role of artificial cerebrospinal fluid as perfusate in neuroendoscopic surgery: A basic investigation -- Subdural or intraparenchymal placement of long-term telemetric ICP- measurement-devices? -- VI Clinical Studies: Hydrocephalus -- A twelve-year hospital outcome on patients with idiopathic hydrocephalus -- What is the appropriate shunt system for Normal Pressure Hydrocephalus? -- Indications for endoscopic third ventriculostomy in normal pressure hydrocephalus -- The Role of Endoscopic Third Ventriculostomy in the Treatment of Selected Patients with Normal Pressure Hydrocephalus -- Endoscopic third ventriculostomy in obstructive hydrocephalus. Surgical technique and pitfalls -- Benign cerebral aqueduct stenosis in an adult -- Efficacy and versatility of the 2-micron continuous wave laser in neuroendoscopic procedures -- Complications of endoscopic third ventriculostomy. A meta-analysis -- Syndrome of inappropriately low-pressure acute hydrocephalus (silpah)* (* previously known as negative-pressure hydrocephalus) -- Lhermitte-Duclos disease presenting with hydrocephalus -- Atypical meningioma in the posterior fossa associated with colpocephaly and agenesis of the corpus callosum -- The management of the intraventricular hemorrhage in preterm infant with low birth weight -- Pathophysiology of Brain Stem Lesions Due to Overdrainage -- Dynamics of CSF flow in slit ventricle syndrome -- Quality and safety of home ICP monitoring compared to in-hospital monitoring.-
  • The metabolism of sulfur especially by sulfurtransferases had been intensively studied in mid 1900s. Three enzymes, cystathionine synthase (CBS), cystathionine lyase (CSE) and 3-mercaptopyruvate sulfurtransferase (3MST) were found to have the capacity to produce H2S in vitro. However, H2S was recognized simply as a by-product of the metabolic pathways or as a marker for evaluating the activity of enzymes rather than as a physiological active molecule. In the late 1980s relatively high concentrations of sulfide were measured in the brain that led to the successive studies of identifying the physiological functions of H2S. Recently, the steady-state concentrations of H2S have been re-evaluated and found to be much less than that initially measured. However, despite these differences, such re-evaluations served to further confirm the existence of H2S in mammalian tissues. H2S is produced in almost every organ and plays various roles such as neuromodulation, vasodilation, insulin release, inflammation, angiogenesis and cytoprotection. The unregulated production of H2S and improper responses of target molecules are involved in the pathogenesis of various diseases. This book focuses on these topics as well as on the recent progress in the biology and the therapeutic development of this molecule.
  • pt. B ScienceDirect
  • Anaerobic eukaryotes in pursuit of phylogenetic normality: the evolution of hydrogenosomes and mitosomes / W. Martin -- Protein import into hydrogenosomes and mitosomes / S. D. Dyall, P. Doležal -- Structure of the hydrogenosome / M. Benchimol -- Hydrogenosomes of anaerobic ciliates / J. H. P. Hackstein ... [et al.] -- Metabolism of trichomonad hydrogenosomes / I. Hrdý, J. Tachezy, M. Müller -- Hydrogenosomes of anaerobic chytrids: an alternative way to adapt to anaerobic environments / J. H. P. Hackstein ... [et al.] -- The proteome of T. vaginalis hydrogenosomes / K. Henze -- Hydrogenosome: the site of 5-nitroimidazole activation and resistance / J. Kulda, I. Hrdý -- Mitosomes in parasitic protists / J. Tachezy, O. Šmíd -- The mitochondrion-related organelle of Cryptosporidium parvum / J. S. Keithly -- Mitochondrial remnant in blastocystis / N. Yarlett, K. S. W. Tan -- Possible mitochondria-related organelles in poorly-studied "amitochondriate" eukaryotes / V. Hampl, A. G. B. Simpson.
  • Aqueous Normal-Phase Chromatography -- Application of the Calculated Physicochemical Property, Log D, to Hydrophilic Interaction Chromatography in the Bioanalytical Laboratory -- HILIC Behavior of Reversed-Phase/Ion-Exchange Mixed-Mode Stationary Phases and Their Applications -- Mechanisms Controlling the Separation and Retention of Proanthocyanidins and Other Plant Polyphenols in Hydrophilic Interaction Chromatography -- Applications of Hydrophilic Interaction Chromatography to Food Analysis -- Hydrophilic Interaction Liquid Chromatography-Mass Spectrometry (HILIC-MS) of Paralytic Shellfish Poisoning Toxins, Domoic Acid and Assorted Cyanobacterial Toxins -- Application of HILIC for Polar Environmental Contaminants (Including Pharmaceuticals) in Aquatic Systems -- Hydrophilic Interaction Chromatography-Mass Spectrometry -- Clinical Applications of Hydrophilic Interaction Liquid Chromatography -- Dimethylarginine Analysis by HILIC-MS/MS and Its Applications in Clinical Chemistry and In Vivo Animal Models -- Polar Functional Groups for HILIC Method -- Analysis of Pharmaceutical Impurities Using Hydrophilic Interaction Liquid Chromatography -- Fast In-Process Method for the Determination of Ioversol and Related Polar Compounds by Hydrophilic Interaction Chromatography (HILIC) and UPLC -- Retention Behavior of Hydrazine Derivatives in HILIC Mode -- HILIC Retention Behavior and Method Development for Highly Polar Basic Compounds Used in Pharmaceutical Synthesis -- Retention of Polar Acidic and Basic Drugs by HILIC -- Retention and Selectivity of Polar Stationary Phases for Hydrophilic Interaction Chromatography -- HILIC-MS/MS for the Determination of Polar Bioactive Substances -- Method Development and Analysis of Mono- and Diphosphorylated Nucleotides by HILIC HPLC-ESI-MS -- Hydrophilic Interaction Liquid Chromatography-Based Enrichment Protocol Coupled to Mass Spectrometry for Glycoproteome Analysis -- Development and Application of Methods for Separation of Carbohydrates by Hydrophilic Interaction Liquid Chromatography -- Hydrophilic Interaction Liquid Chromatography in the Characterization of Glycoproteins -- Analysis of Protein Glycosylation and Phosphorylation Using HILIC-MS.
  • This detailed volume addresses key issues and subtle nuances involved in developing hydrophilic matrix tablets as an approach to oral controlled release. It brings together information from more than five decades of research and development on hydrophilic matrix tablets and provides perspective on contemporary issues. Twelve comprehensive chapters explore a variety of topics including polymers (hypromellose, natural polysaccharides and polyethylene oxide) and their utilization in hydrophilic matrices, critical interactions impacting tablet performance, in vitro physical and imaging techniques, and microenvironmental pH control and mixed polymer approaches, among others. In one collective volume, Hydrophilic Matrix Tablets for Oral Controlled Release provides a single source of current knowledge, including sections of previously unpublished data. It is an important resource for industrial and academic scientists investigating and developing these oral controlled release formulations.
  • "Malpractice settlements are large for undetected hydroxychloroquine and chloroquine toxicity which, if untreated, can lead to permanent loss of central vision. Knowledge of the ocular toxicity of these drugs has increased during the past fifty years as their use has expanded. Hydroxychloroquine and Chloroquine Retinopathy is the first single-source book on the subject and is essential for the practicing ophthalmologists, rheumatologists, dermatologists, and internists who prescribe these drugs. It covers clinical topics such as signs and symptoms of toxicity, toxicity screening, ancillary testing, to whom and why the drugs are prescribed and dosing considerations. Additionally, the book addresses practice management considerations, including coding, reimbursement and equipment costs, and the medico-legal responsibilities of the rheumatologist and of the ophthalmologist. Guidelines for the management of hydroxychloroquine and chloroquine vary around the world and differences between the guidelines of the United Kingdom, the United States, and other countries are identified. The book concludes with a collection of case examples illustrating common clinical scenarios and their management. This book is a “must-have” resource for physicians who use these drugs."--Publisher's website.
  • Pathophysiology of hyperkinetic movement disorders -- Huntington disease and other choreas -- Dystonia -- Tourette syndrome and the spectrum of neurodevelopmental tic disorders -- Myoclonus -- Paroxysmal dyskinesias -- Psychogenic movement disorders -- Drug-induced hyperkinetic movement disorders -- Hyperkinetic disorders in childhood -- Surgery for hyperkinetic movement disorders.
  • Print Material
    1. The Basal Ganglia -- 2. Tremor -- 3. Dystonia: Part I -- 4. Dystonia: Part 2 -- 5. Chorea, Athetosis and Ballism -- 6. Tourette's Syndrome and Other Tic Disorders -- 7. Habits, Mannerisms, Compulsions, and Stereotypies --8. Myoclonus and Asterixis -- 9. Restless Legs Syndrome -- 10. Drug-Induced Movement Disorders -- 11. Wilson's Disease -- 12. Peripherally Induced Movement Disorders -- 13. Psychogenic Hyperkinetic Movement Disorders -- 14. The Ataxias -- Appendix. Resources for Clinicians and Patients -- Index.
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  • Cardiovascular Risk Assessment -- The Metabolic Syndrome -- The Role of Imaging in Cardiovascular Risk Assessment -- Inherited Lipoprotein Disorders -- Advanced Lipid Testing -- Therapeutic Lifestyle Change for the Prevention and Treatment of Hyperlipidemia and Coronary Artery Disease -- Drug Therapy for Dyslipidemia -- Hypertriglyceridemia -- Isolated Low HDL -- Lipoprotein(a) -- HIV with Dyslipidemia -- Treatment of Dyslipidemia in Patients with Renal Insufficiency and End-Stage Renal Disease.
  • Hypertension 2013
    Future Med
    Update on hypertension, its genetics, epidemiology, mechanisms, clinical approaches and novel treatments / Ernesto L. Schiffrin & Rhian M. Touyz -- Definition & diagnosis of hypertension / Ernesto L. Schiffrin -- Epidemiology of hypertension / Stanley S. Franklin & Nathan D. Wong -- Genetics of hypertension / Christian Delles -- Hemodynamics / Joseph L. Izzo Jr. -- Role of the kidney in hypertension / John E. Hall, Jussara M. do Carmo, Alexandre A. da Silva, Zhen Wang & Michael E. Hall -- Renin-angiotensin-aldosterone system : new concepts / Aurelie Nguyen Dinh Cat, Augusto C. Montezano & Rhian M. Touyz -- Endothelin system : roles in hypertension / Yohann Rautureau & Ernesto L. Schiffrin -- CNS pathways contributing to sympathetic hyperactivity and hypertension / Frans H.H. Leenen -- Hypertensive vascular disease / Carmine Savoia & Ernesto L. Schiffrin -- Hypertensive heart disease / Javier Díez -- Classification and diagnosis of hypertension / Clive Rosendorff -- Hypertension and cardiovascular risk / Maria Czarina Acelajado & Suzanne Oparil -- Lifestyle modifications / Franz Messerli & Tiberio Frisoli -- Antihypertensive agents / Domenic A. Sica -- Treatment of hypertension / Ross D. Feldman -- Clinical practice guidelines / Sheldon W. Tobe, Diane Hua & Patrick Twohig -- Resistant hypertension / David A. Calhoun -- Index.
  • 2008 Ovid
  • Hypertension has become a major public health hazard not only in industrialized nations, but also in emerging economies. Early detection combined with effective treatment is imperative to reduce the risk of patients developing premature cardiovascular disease and accelerated atherosclerosis. A clear, concise resource, Hypertension: A Clinical Guide is of practical value to primary care doctors around the world who treat patients with hypertension every day. The book explores both fundamental and practical aspects, including epidemiology, risk, treatment, and secondary causes. After discussing methods of diagnosis and evaluation, the book explores a range of pharmacological and non-pharmacological treatment options. Specialized chapters address topics such as hypertensive emergencies, hypertension in pregnancy and renal disease, renovascular hypertension, primary hyperaldosteronism, and pheochromocytoma. Illustrated with photos and tables, this volume is essential reading for physicians, nurses, and allied health professionals with an interest in hypertension whether in primary care, in hospitals, or in training.
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  • Blood pressure: definition, diagnosis, and management -- The link between hypertension and stroke: summary of observational epidemiological studies -- Blood pressure control and primary prevention of stroke: summary of clinical trial data -- Mechanisms underlying essential hypertension: neurogenic and nonneurogenic contributors -- Pathophysiology and mechanisms whereby hypertension may cause stroke -- Cardiovascular risk assessment and summary of guidelines for the management of hypertension -- Acute blood pressure management after ischemic stroke -- Hypertensive encephalopathy and acute blood pressure management after hemorrhagic stroke -- Recurrent stroke prevention I: diuretic and angiotensin-converting enzyme inhibitors (ACEIs): the PROGRESS trial -- Recurrent stroke prevention II: angiotensin receptor blockers: the LIFE, MOSES, PRoFESS, and other trials -- A practical guide to recurrent stroke prevention -- Vascular cognitive impairment and Alzheimer disease: are these disorders linked to hypertension and other cardiovascular risk factors? -- Cerebral small vessel disease, hypertension, and cognitive function -- Cerebral microbleeds, small-vessel disease of the brain, hypertension, and cognition -- Imaging effects of hypertension on the brain: a focus on new imaging modalities and options -- The Joint Commission's initiatives to improve stroke care and what it means for acute stroke care and prevention.
  • This volume discusses the many ways to prevent, identify and control hypertension in African Americans, a common and potent risk factor for virtually all forms of cardiovascular-renal diseases. Comprehensive chapters address modifiable risk factors, such as lifestyle changes, especially sodium restriction, and appropriate combination pharmacotherapy. Emerging devices and evidence-based approaches that may also enhance effective blood pressure control and decrease the disparate cardiovascular disease risks, including MI, stroke, HF, and cardiorenal metabolic syndrome and diabetes are also discussed in detail. Written by a wide-range of experts in the field, Hypertension in High Risk African Americans: Current Concepts, Evidence-based Therapeutics and Future Considerations is a valuable resource for clinicians, researchers, health administrators and public health policy leaders to better understand the best practices and unique aspects of risk assessment and treatment of hypertension and co-morbid conditions in African Americans.
  • The importance of hypertension in the geriatric population / Ray W. Gifford and L. Michael Prisant -- Age-related changes in the cardiovascular system / R. Clinton Webb and Edward W. Inscho -- Aging, arterial stiffness, and systolic hypertension / Joseph L. Izzo -- Pharmacological and pharmacodynamic alterations in the elderly: application to cardiovascular therapies / Domenic A. Sica -- Epidemiology of hypertension in the older patient / William B. Kannel and Peter W. F. Wilson -- Nonpharmacological trials in the older patient / L. Michael Prisant and Dean U. Harrell -- Clinical trials of hypertension in older patient / L. Michael Prisant -- Blood pressure measurement in the older patients with hypertension / Jose Ramiro Arias-Vera and William B. White -- Clinical evaluation of the elderly hypertensive / L. Michael Prisant and Thomas W. Jackson -- Hypertension in the elderly: endocrine causes of secondary hypertension / Carlos M. Isales -- Diagnosis and management of hypertensive renal and renovascular disease in the elderly / Wanpen Vongpatanasin and Ronald G. Victor -- Heart failure in the older hypertensive patient / L. Michael Prisant ... [et al.] -- Management of ischemic heart disease in the older hypertensive patient: evaluation and management / Jan Laws Houghton -- Cerebrovascular disease in the elderly hypertensive / Fenwick T. Nichols, III -- Diuretics and beta-adrenergic blockers in the management of hypertension in the elderly / William C. Cushman -- Assessment of the role ace inhibitors in the elderly / Domenic A. Sica -- Use of angiotensin receptor blockers in the elderly / L. Michael Prisant -- Clinical trials with calcium antagonists in older patients with hypertension / William B. White and Sumeska Thavarajah -- Alpha-adrenoceptor blockers for management of hypertension in the elderly / James L. Pool -- Combination drug therapy in the elderly / L. Michael Prisant and Laura Lyngby Mulloy -- Attitudes regarding hypertension among older african-american adults / Wallace R. Johnson and Elijah Saunders -- Treatment of hypertension in the elderly diabetic patient / James R. Sowers and L. Michael Prisant -- Management of hypertension in older patients with arthritis / Sumeska Thavarajah and William B. White -- The clinician's role in improving therapeutic adherence and blood pressure control in older hypertensive patients / Brent M. Egan and Eni C. Okonofua.
  • Hypertension methods and protocols 2005
    Springer Protocols
  • Effectively manage the chronic problems of your hypertensive patients with the practical clinical tools inside Hypertension, 2nd Edition: A Companion to Braunwald's Heart Disease. This respected cardiology reference covers everything you need to know - from epidemiology and pathophysiology through diagnosis, risk stratification, treatment, outcome studies, concomitant diseases, special populations and special situations, and future treatments. Confidently meet the needs of special populations with chronic hypertensive disease, as well as hypertension and concomitant disease. Learn new methods of aggressive patient management and disease prevention to help ensure minimal risk of further cardiovascular problems. Benefit from the authors' Clinical Pearls to reduce complications of hypertension.
  • Hyperthermophilic enzymes. Part A-C pt. A-C, 2001.
    pt. B ScienceDirect
    pt. C ScienceDirect
  • This book provides a comprehensive clinical review of Hypertrophic Cardiomyopathy (HCM), the most common genetic disorder of the heart characterized by dysfunctional contractility at the sarcomere level, resulting in the development of abnormal and occasionally focal hypertrophy on a macroscopic level. Editor, Srihari S. Naidu, has brought together a world renowned group of experts to review various different topics but, with a practical focus that will enable readers to establish the evidence-based best practice in any potential scenario. Treatment modalities including medications, pacemakers and defibrillators, and invasive septal reduction therapy (both surgical myectomy and alcohol septal ablation) will be discussed. Chapters on genetics, family screening, lifestyle concerns, and athletic screening have additionally been added given the ongoing controversies and differences of opinion on many of these issues. Each chapter within Hypertrophic Cardiomyopathy begins with key points of knowledge and ends with clinical pearls that have not previously been disseminated to the wider community. The practical approach of the entire book continues with dedicated chapters on creating a Center of Excellence, including how to facilitate the multi-disciplinary approach, and on case-based reviews and discussions allowing readers to further understand how to integrate the knowledge gained from each chapter into the comprehensive and longitudinal care of the individual patient and family. The last chapter takes the reader through the management of actual patients, showing over decades the nuances to diagnosis and management and the sometimes abrupt changes in the course of their diseases that necessitate correspondingly abrupt modifications in treatment. This book will be an essential text for Trainees, Fellows, Residents and board-certified physicians in cardiology, interventional cardiology, cardiac surgery, cardiac imaging, sports medicine, paediatric cardiology, genetics and genetic counselling, and electrophysiology.
  • Purine metabolism and hyperuricemic states: 'The point of view of the rheumatologist' / G. Peronato -- Inherited hyperuricemic disorders / W.L. Nyhan -- Pharmacology of drugs for hyperuricemia: mechanisms, kinetics and interactions / F. Pea -- Hyperuricemic syndromes in cancer patients / A.-M. Tsimberidou, M.J. Keating -- Incidence and pathogenesis of tumor lysis syndrome / F. Locatelli, F. Rossi -- Recombinant urate oxidase (rasburicase) in the prophylaxis and treatment of tumor lysis syndrome / S. Jeha, C.-H. Pui -- Treatment and prevention of tumor lysis syndrome in children: experience of Associazione Italiana Ematologia Oncologia Pediatrica / A. Pession, E. Barbieri -- Intensive chemotherapy in patients with lymphoma: management of the risk of hyperuricemia / C. Tarella ... [et al.] -- Hyperuricemia and bone marrow transplantation / G. Lambertenghi Deliliers, C. Annaloro -- Rasburicase therapy in acute hyperuricemia and renal dysfunction / C. Ronco ... [et al.] -- Hyperuricemia in kidney transplantation / N. Perico ... [et al.] -- Uric acid elimination in the urine: pathophysiological implications / M. Marangella -- Pharmacological treatment of acute and chronic hyperuricemia in kidney diseased patients / G. Bellinghieri, D. Santoro, V. Savica -- Pharmacological treatment of acute renal failure in intensive care unit patients / D. Moreau.
  • Epidemiology and Significance of Hyponatremia -- Physiology of Water Balance and Pathophysiology of Hyponatremia -- Utility of Electrolyte-Free Water Clearance in the Analysis and Treatment of the Dysnatremias -- Cerebral-Renal Salt Wasting -- CNS Manifestations of Hyponatremia and Its Treatment -- Hyponatremia Induced by Drugs -- Hyponatremia in Heart Failure -- Hyponatremia in Cirrhosis: Evaluation and Treatment -- Hyponatremia in Psychosis -- Exercise-Associated Hyponatremia -- Vasopressin Receptor Antagonists -- Treatment of Hyponatremia.
  • Hypoparathyroidism 2015
    Hypoparathyroidism, a condition in which insufficient parathyroid hormone (PTH) is produced to maintain normocalcemia is associated with a variety of acute and chronic symptoms and complications due to hypocalcemia. Replacement therapy utilizing PTH has long been awaited, and this book is new and very timely as it coincides with the ℗ℓpublication of results on the role of the PTH molecule in the pharmacological management of this disorder. This advance is sparking renewed interest in hypoparathyroidism, which is attributable to neck surgery in most cases and to inherited disorders in a minority. Hypoparathyroidism has been written by acknowledged experts in the field and provides essential, up-to-date information on the pathology, diagnosis, and treatment of the condition. It opens by addressing in detail the anatomy and physiology of the parathyroids and describing the epidemiology and clinical presentation of hypoparathyroidism. The full range of hypoparathyroid disorders are then discussed, including the various genetic forms, postoperative hypoparathyroidism, and other forms of acquired hypoparathyroidism. Individual chapters focus on refractory disease, the impact of the condition on bone, and the management of acute hypocalcemia. Both conventional treatment for hypoparathyroidism and the novel replacement therapy with PTH ℗ℓpeptides are then thoroughly examined. Pseudohypoparathyroidism is also extensively discussed, with information on the various forms, differential diagnosis, and genetic testing. This book will be of interest to all endocrinologists, and also to surgeons and internal medicine physicians. ℗ℓ
  • Hypoxia and breast cancer metastasis / Luana Schito and Gregg L. Semenza -- Hypoxia and DNA damage response / Monica M. Olcina and Ester M. Hammond -- Emerging roles of non-coding RNAs in the hypoxic response / Mircea Ivan ... [et al.] -- Hypoxia and reactive oxygen species / Agnes Gorlach -- Hypoxia and gene expression / Maria Carla Bosco and Luigi Varesio -- Carbonic anhydrase IX : from biology to therapy / Silvia Pastorekova and Claudiu T. Supuran -- Imaging the hypoxic tumor microenvironment in preclinical models / Mary-Keara Boss, Gregory M. Palmer and Mark W. Dewhirst -- Clinical imaging of hypoxia / Michael R. Horsman ... [et al.] -- Hypoxia, metastasis, and antiangiogenic therapies / Dietmar W. Siemann, Yao Dai and Michael R. Horsman -- Unfolded protein response and therapeutic opportunities / Carly M. Sayers ... [et al.] -- Small molecules targeting the VHL/hypoxic phenotype / Raymond J. Louie ... [et al.] -- Hypoxia and radiation therapy / Marianne Nordsmark ... [et al.] -- Prodrug strategies for targeting tumour hypoxia / William R. Wilson ... [et al.] -- Exploiting "Hif addiction" for cancer therapy / Nicole D. Fer and Annamaria Rapisarda -- Clinical exploitation of hypoxia / Geoff S. Higgins and Adrian L. Harris.
  • Hypoxia honoree. -- A tribute to John Burnard West / James S. Milledge. Adventures in High-altitude physiology / John B. West -- Exercise-induced hypoxemia (EIH): causes and consequences. -- Exercise induced arterial hypoxemia: the role of ventilation-perfusion inequality and pulmonary diffusion limitation / Susan R. Hopkins. Intrapulmonary shunt during normoxic and hypoxic exercise in healthy humans / Andrew T. Lovering, Michael K. Stickland, Marlowe W. Eldridge. Exercise-induced arterial hypoxemia: consequences for locomotor muscle fatigue / Lee M. Romer ... [et al.] -- Causes and effects of sleep-disordered breathing. -- Mechanisms of sleep apnea at altitude / William Whitelaw. Control of cerebral blood flow during sleep and the effects of hypoxia / Douglas R. Corfield and Guy E. Meadows. Neural consequences of sleep disordered breathing: the role of intermittent hypoxia / Mary J. Morrell and Gillian Twigg -- Genetic, genomics, and adaptation to high altitude. -- Finding the genes underlying adaptation to hypoxia using genomic scans for genetic adaptation and admixture mapping / Mark D. Shriver ... [et al.] An evolutionary model for identifying genetic adaptation to high altitude / Lorna G. Moore ... [et al.] Hypoxic preconditioning and erythropoietin protect retinal neurons from degeneration / Christian Grimm ... [et al.] -- Blocking stress pathways with cell-permeable membranes. -- Blocking stress signaling pathways with cell permeable peptides / Christophe Bonny. JNK pathway as therapeutic target to prevent degeneration in the central nervous system / Mariaelena Repici and Tiziana Borsello. Salvage of ischemic myocardium: a focus on JNK / Hervé Duplain -- The impact of immobilization and hypoxia on skeletal muscle. -- Mitochondrial reactive oxygen species are required for hypoxic hif[alpha] stabilization / M. Celeste Simon. Hypoxia-induced gene activity in disused oxidative muscle / Christoph Däpp ... [et al.] -- Hypoxic vasoregulation: interactions of red cells, endothelium, and smooth muscle. -- Role of the red blood cell in nitric oxide homeostasis and hypoxic vasodilation / Mark T. Gladwin. Expression of the heterotrimeric G protein gi and ATP release are impaired in erythrocytes of humans with diabetes mellitus / Randy Sprague ... [et al.] Red blood cells and hemoglobin in hypoxic pulmonary vasoconstriction / Steven Deem -- Hypoxia: state of the art. -- Dose-response of altitude training: how much altitude is enough? / Benjamin D. Levine, James Stray-Gundersen. The eye at altitude / Daniel S. Morris ... [et al.] Lake Louise consensus methods for measuring the hypoxic ventilatory response / Frank L. Powell -- Future directions in hypoxia research. -- Pulmonary hypertension in high-altitude dwellers: novel mechanisms, unsuspected predisposing factors / Urs Scherrer ... [et al.] Gene huntin in hypoxia and exercise / Kenneth B. Storey.
  • Risk of cardiovascular events during mountain activities / Martin Burtshcer -- Biventricular function at high altitude: implications for regulation of stroke volume in chronic hypoxia / Simon R. Gibbs -- Control of coronary blood flow during hypoxemia / Johnathan D. Tune -- Metabolic consequences of intermittent hypoxia / Christopher P. O'Donnell -- Intermittent hypoxia and cognitive function: implications from chronic animal models / Barry W. Row -- Vascular consequences of intermittent hypoxia / Barbara J. Morgan -- Angiotensin-induced hypoxia in the kidney: functional and structural changes of the renal circulation / Masaomi Nangaku ... [et al.] -- Role of reactive oxygen species in chronic hypoxia-induced pulmonary hypertension and vascular remodeling / Eva Nozik-Grayck and Kurt R. Stenmark -- Hypoxia and placental remodeling / Judith E. Cartwright ... [et. al.] -- Epithelial sodium channels in the adult lung - important modulators of pulmonary health and disease / Ian C. Davis and Sadis Matalon -- Lung interstitial pressure and structure in acute hypoxia / Giuseppe Miserocchi -- Hypoxic inhibition of alveolar fluid reabsorption / Laura A. Dada and Jacob I. Sznajder -- Regulation and role of neuroglobin in cytoglobin under hypoxia / Thorsten Burmester, Frank Gerlach, and Thomas Hankeln -- Molecular insights into the functional role of myoglobin / Daniel J. Garry and Pradeep P.A. Mammen -- Genetic mechanisms underlying regulation of hemoglobin mass / neeraj Agarwal, Victor R. Gordeuk, and Josef T. Prchal -- Control of the respiratory patterns in insects / Timothy J. Bradley -- Effects of insect body size on tracheal structure and function / Scott D. Kirkton -- The role of HIF-1 in hypoxic response in the skeletal muscle / Steven Mason and Randall S. Johnson -- Gene expression in working skeletal muscle / Hans Hoppeler, Stephan Klossner, and Martin Fluck -- The limits of human endurance: what is the greatest endurance performance of all time? Which factors regulate performance at extreme altitude / Timothy David Noakes -- Jim Milledge: hypoxia honoree 2007 / Annabel Nikol -- Exploring mountain medicine and physiology / James S. Milledge -- Carlos Monge Cassinelli: a portrait / Fabiola Leon-Velarde S. and Jean-Paul Richalet.
  • The evolution of uterine surgery and hysterectomy / Anthony Tizzano and Mark D. Walters -- Anatomy of the uterus and its surgical removal / Amy J. Park and Matthew D. Barber -- Epidemiology and indications of hysterectomy : changing trends / Matthew D. Barber -- Pre- and peri-operative considerations and choosing the route of hysterectomy / Mark D. Walters and Tommaso Falcone -- Outcomes of hysterectomy / Matthew D. Barber and Mark D. Walters -- Abdominal hysterectomy / Beri Ridgeway -- Vaginal hysterectomy and trachelectomy : basic surgical techniques / Mark D. Walters -- Difficult vaginal hysterectomy / Matthew D. Barber -- Prophylactic oophorectomy at hysterectomy / James L. Whiteside and Rebecca S. Uranga -- Laparoscopic and robotic-assisted total and supracervical hysterectomy / Marie Fidela R. Paraiso and Pedro F. Escobar -- Complications during hysterectomy / Mark D. Walters and Matthew D. Barber -- Alternative treatments to hysterectomy / Linda D. Bradley and Devorah R. Wieder -- Teaching and learning gynecologic surgery / Gouri B. Diwadkar and J. Eric Jelovsek.
  • Before Charcot / Pearce, J.M.S -- Socioeconomic background of hysteria's metamorphosis from the 18th century to World War I / Edelman, N.; Walusinski, O. -- "Fin-de-siècle" epidemiology of hysteria / Luauté, J.-P. -- Clinical manifestations of hysteria: an epistemological perspective or how historical dynamics illuminate current practice / Medeiros De Bustos, E.; Galli, S.; Haffen, E.; Moulin, T. -- Jean-Martin Charcot and his legacy / Bogousslavsky, J. -- Hypnosis and the Nancy Quarrel / Piechowski-Jozwiak, B.; Bogousslavsky, J. -- The girls of La Salpêtrière / Walusinski, O. -- Public medical shows / Walusinski, O. -- Emma Bovary, Hedda Gabler, and Harold Brodkey would not have lived without Charcot: hysteria in novels / Kaptein, A.A. -- Traces of hysteria in novels / Haan, J.; Koehler, P.J. -- Sigmund Freud and hysteria: the etiology of psychoanalysis? / Bogousslavsky, J.; Dieguez, S. -- Paul Sollier, Pierre Janet, and their vicinity / Walusinski, O. -- Criticism of pithiatism: eulogy of Babinski / Poirier, J.; Derouesné, C. -- The borderland with neurasthenia ("functional syndromes") / Paciaroni, M.; Bogousslavsky, J. -- World War I psychoneuroses: hysteria goes to war / Tatu, L.; Bogousslavsky, J. -- Hysteria around the world / Carota, A.; Calabrese, P. -- History of physical and "moral" treatment of hysteria / Broussolle, E.; Gobert, F.; Danaila, T.; Thobois, S.; Walusinski, O.; Bogousslavsky, J. -- "Hysteria" today and tomorrow / LaFrance, W.C.
  • This new text presents authoritative in-depth coverage of hysteroscopy, a quick in-office procedure for an accurate diagnosis of abnormal vaginal bleeding, uterine adhesions, foreign bodies, uterine structural defects, anatomic defects, and infertility. More than 380 full-color images provide a real-life practice perspective of the conditions you'll encounter. This procedure enables you to take a direct view of any pathology, without the risk of radiation exposure, and decreases the chances of uterine perforation. Chapters encompass a full range of clinical considerations, including instrumentation, imaging, complications, and endometrial ablation. Provides chapters that detail the instrumentation you'll need to effectively perform hysteroscopic procedures. Features a full chapter on imaging, including saline infusion sonography, keeping you current on the latest imaging technology. Offers expert guidance on endometrial ablation, a frequent office procedure used to diagnose and treat abnormal bleeding. Presents coverage of diagnostic and operative hysteroscopy, enabling you to incorporate this technology of increasing clinical use into your practice. Features a color design with more than 380 full-color images that highlight techniques and equip you with a real-life practice perspective.

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