- G protein coupled receptors. Modeling, activation, interactions and virtual screening — Genetic basis of common diseases. 2nd ed. (165)
- Genetic cardiomyopathies : a clinical approach — Geriatric trauma and critical care (165)
- Geriatric urology — Good manufacturing practices for pharmaceuticals. 6th ed. (165)
- Good pharmaceutical manufacturing practice : rationale and compliance — Gynecological imaging : a reference guide to diagnosis (165)
- 2013 ScienceDirectConn, P. Michael.The protein local optimization program and g-protein-coupled receptors:loop restoration and applications to homology modeling -- Modeling active GPCR conformations -- Molecular modeling of adenosine receptors -- Predicting g-protein-coupled receptors families using differet physiochemical properties and pseudo amino acid composition -- Computational design and experimental characterization of GPCR segment models -- G-protein-coupled receptor interaction with small GTPases -- Quantification of receptor tyrosine kinase activiation and transactivation by G-protein-coupled receptors using spatial intensity distribution analysis (SplDA) -- NMR modeling for detection of small molecule binding to RGS4 -- Group II activators of g-protein signaling: monitoring the interaction of G[alpha] with G-protein motif in the intact cell -- Homogenous time-resolved fluorescence assay to probe folded G protein-coupled receptors -- cAMP biosensors applied in molecular pharmacological studies of G protein-coupled receptors -- Rhodospin-lipid intereactions studied by NMR -- Biasing the parathyroid hormone receptor: relating in vitro ligand efficacy to in vivo biological activity -- Application of Monte Carlo-based receptor ensemble docking to virtual screening for GPCR ligands -- From heptahelical bundle to hits from the haystack: structure-based virtual screening for GPCR ligands -- Kinetics and dynamics in the G protein-coupled receptor signaling cascade -- Magic angle spinning nuclear magnetic resonance spectroscopy fo G protein-coupled receptors -- Posttranslation modification of G protein-coupled receptor in relationship to biased agonism -- Protein S-nitrosylation measurement.
- 2013 ScienceDirectConn, P. Michael.This new volume of Methods in Enzymology continues the legacy of this premier serial by containing quality chapters authored by leaders in the field. This volume covers G protein coupled receptors and includes chapters on such topics as post-translation modification of GPCR in relationship to biased agonism, structure-based virtual screening, and GPCR oligomerization in the brain. This new volume of Methods in Enzymology continues the legacy of this premier serial by containing quality chapters authored by leaders in the field. This volume covers G protein coupled receptors and includes chapters on such topics as post-translation modification of GPCR in relationship to biased agonism, structure-based virtual screening, and GPCR oligomerization in the brain.
- 2013 ScienceDirectConn, P. Michael.Section 1. GPCR trafficking. Therapeutic rescue of misfolded/mistrafficked mutants : automation-friendly high-throughput assays for identification of pharmacoperone drugs of GPCRs / David C. Smithson, Jo Ann Janovick, and P. Michael Conn ; Trafficking of the follitropin receptor / Alfredo Ulloa-Aguirre, James A. Dias, George Bousfield, Ilpo Huhtaniemi, and Eric Reiter ; Single-molecule imaging technique to study the dynamic regulation of GPCR function at the plasma membrane / B.E. Snaar-Jagalska, A. Cambi, T. Schmidt, and S. de Keijzer ; GPCR oligomerization and receptor trafficking / Richard J. Ward, Tian-Rui Xu, and Graeme Milligan ; [Beta]-arrestins and G protein-coupled receptor trafficking / Dong Soo Kang, Xufan Tian, and Jeffrey L. Benovic ; Tracking cell surface mobility of GPCRs using [alpha]-bungarotoxin-linked fluorophores / Saad Hannan, Megan E. Wilkins, Philip Thomas, and Trevor G. Smart ; Regulatory mechanism of G protein-coupled receptor trafficking to the plasma membrane : a role for mRNA localization / Kusumam Joseph, Eleanor K. Spicer, and Baby G. Tholanikunnel ; Dissecting trafficking and signaling of atypical chemokine receptors / Elena Borroni, Cinzia Cancellieri, Massimo Locati, and Raffaella Bonecchi -- Section 2. Trafficking motifs. Systematic and quantitative analysis of G protein-coupled receptor trafficking motifs / Carl M. Hurt, Vincent K. Ho, and Timothy Angelotti ; Identification of endoplasmic reticulum export motifs for G protein-coupled receptors / Guangyu Wu ; Amino acid residues of G-protein-coupled receptors critical for endoplasmic reticulum export and trafficking / Motonao Nakamura, Daisuke Yasuda, Nobuaki Hirota, Teruyasu Yamamoto, Satoshi Yamaguchi, Takao Shimizu, and Teruyuki Nagamune -- Section 3. GPCR oligomerization. G-protein-coupled heteromers : regulation in disease / Ivone Gomes, Achla Gupta, and Lakshmi A. Devi ; Hetero-oligomerization and specificity changes of G protein-coupled purinergic receptors : novel insight into diversification of signal transduction / Tokiko Suzuki, Kazunori Namba, Natsumi Mizuno, and Hiroyasu Nakata ; Bimolecular fluorescence complementation analysis of G protein-coupled receptor dimerization in living cells / Karin F.K. Ejendal, Jason M. Conley, Chang-Deng Hu, and Val J. Watts ; G protein-coupled receptor heterodimerization in the brain / Dasiel O. Borroto-Escuela, Wilber Romero-Fernandez, Pere Garriga, Francisco Ciruela, Manuel Narvaez, Alexander O. Tarakanov, Miklós Palkovits, Luigi F. Agnati, and Kjell Fuxe ; Experimental strategies for studying G protein-coupled receptor homo- and heteromerization with radioligand binding and signal transduction methods / Roberto Maggio, Cristina Rocchi, and Marco Scarselli ; Analysis of GPCR dimerization using acceptor photobleaching resonance energy transfer techniques / Marta Busnelli, Mario Mauri, Marco Parenti, and Bice Chini ; Techniques for the discovery of GPCR-associated protein complexes / Avais Daulat, Pascal Maurice, and Ralf Jockers ; Expression, purification, and analysis of G-protein-coupled receptor kinases / Rachel Sterne-Marr, Alison I. Baillargeon, Kevin R. Michalski, and John J.G. Tesmer ; Modern methods to investigate the oligomerization of glycoprotein hormone receptors (TSHR, LHR, FSHR) / Marco Bonomi and Luca Persani.
- 2002 ScienceDirectHildebrandt, John D.; Iyengar, Ravi.
- 2002 ScienceDirectHildebrandt, John D.; Iyengar, Ravi.
- 2002 ScienceDirectHildebrandt, John D.; Iyengar, Ravi.
- 2014 Springer ProtocolsStevens, Craig W.G protein-coupled receptors : research and methods in the post-genomic era / Craig W. Stevens -- Examining the dynamic evolution of G protein-coupled receptors / Claudia Stäubert, Diana Le Duc, and Torsten Schöneberg -- Functional properties of virus-encoded and virus-regulated G protein-coupled receptors / Katja Spiess and Mette M. Rosenkilde -- Discovery and function of the very large G protein-coupled receptor / Perrin C. White and D. Randy McMillan -- Functional evolution of opioid family G protein-coupled receptors / Eyal Vardy, Craig W. Stevens, and Bryan L. Roth -- Investigation of G protein-coupled receptor function and regulation using antisense / Jonathon Willets and Craig Nash -- Signalosome profiling reveals allosteric interactions between G protein-coupled receptors / Katrin Altosaar ... [et al.] -- Use of optogenetic approaches to control intracellular signaling of G protein-coupled receptors / Olivia A. Masseck, Melanie D. Mark, and Stefan Herlitze -- Viral infection for G protein-coupled receptor expression in eukaryotic cells / Antonio Porcellini, Luisa Iacovelli, and Antonio De Blasi -- Using in vitro mutagenesis to characterize structure- function relationships in G protein-coupled receptors / Gregory W. Sawyer and Frederick J. Ehlert -- CRE Luc Mouse model for bioimaging ligand activation of G protein-coupled receptors / H. Gregory Polites and Kyriakos D. Economides -- Inducing conformational changes in G protein-coupled receptors by domain coupling / Hamiyet Unal and Sadashiva S. Karnik -- Rescue of defective G protein-coupled receptor function by intermolecular cooperation / Ashutosh Trehan ... [et al.] -- Design of super-arrestins for gene therapy of diseases associated with excessive signaling of G protein-coupled receptors / Vsevolod V. Gurevich and Eugenia V. Gurevich -- Importance of G protein-coupled receptor genetics in clinical medicine / Ramakrishna Devaki -- Pharmacogenomics of G protein-coupled receptor signaling and other pathways in essential hypertension / Pedro A. Jose ... [et al.] -- Exon sequencing of G protein-coupled receptor genes and perspectives for disease treatment / Angeliki Karamitri and Ralf Jockers -- Gene therapy using G protein-coupled receptors for the treatment of cardiovascular disease / Dario Leosco ... [et al.] -- Novel mechanisms of G protein-coupled receptor oligomer and ion channel Iiteractions in nociception / Ajay S. Yekkirala -- Discovery and characterization of leucine-rich repeat-containing G protein-coupled receptors / Marie-Isabelle Garcia, Valeria Fernandez-Vallone, and Gilbert Vassart -- Role of G protein-coupled receptors in adult neurogenesis / Katie M. Collette, Van A. Doze, and Dianne M. Perez.
- 2015 Springer ProtocolsMartins, Sofia Aires M.; Prazeres, Duarte Miguel F.G protein-coupled receptors : an overview of signaling mechanisms and screening assays / Duarte Miguel F. Prazeres and Sofia Aires M. Martins -- Time-resolved FRET strategy to screen GPCR ligand library / Nadia Oueslati [and others] -- Homogeneous fluorescence anisotropy-based assay for characterization of ligand binding dynamics to GPCRs in budded baculoviruses : the case of Cy3B-NDP-α-MSH binding to MC4 receptors / Santa Veiksina . . [and others] -- Construction of recombinant HEK293 cell lines for the expression of the neurotensin receptor NTSR1 / Su Xiao, Joseph Shiloach, and Reinhard Grisshammer -- cAMP assay for GPCR ligand characterization : application of BacMam expression system / Olga Mazina [and others] -- Ca2+ mobilization assays in GPCR drug discovery / Grzegorz Woszczek and Elisabeth Fuerst -- Using constitutive activity to define appropriate high- throughput screening assays for orphan G protein-coupled receptors / Tony Ngo, James L.J. Coleman, and Nicola J. Smith -- Monitoring G protein-coupled receptor activation using the protein fragment complementation technique split TEV / Michael C. Wehr, Sabrina Galinski, and Moritz J. Rossner -- Quantifying GPCR iternalization : a focus on the kisspeptin receptor / Macarena Pampillo and Andy V. Babwah -- GPCR oligomerization analysis by means of BRET and dFRAP / Francisco Ciruela and Víctor Fernández-Dueñas -- Use of imageJ to recover information from individual cells in a G protein-coupled receptor assay / João R.C. Trabuco, Sofia Aires M. Martins, and Duarte Miguel F. Prazeres -- Methods to immobilize GPCR on the surface of SPR sensors / Laura Martínez-Muñoz [and others] -- Olfactory receptor screening assay using nanovesicle- immobilized carbon nanotube transistor / Jong Hyun Lim [and others] -- Label-free biosensor assays in GPCR screening / Manuel Grundmann and Evi Kostenis -- Multidimensional GPCR profiling and screening using impedance-based label-free and real-time assay / Ning Ke [and others] -- Label-free functional selectivity assays / Ann M. Ferrie [and others] -- Measurement of surface-mediated Ca2+ transients on the single-cell level in a microfluidic lab-on-a-chip environment / Michael Kirschbaum, Magnus S. Jaeger, and Claus Duschl -- Cell-based assays and animal models for GPCR drug screening / Hideo Takakura [and others] -- Computer-aided design of GPCR ligands / Hugo Gutiérrez-de-Terán [and others].
- 2013 Springer ProtocolsRunning, Mark P.Remarkably, while G protein-coupled receptors (GPCRs) are highly prevalent in animals and yeast, very few candidate GPCRs have been identified in plants. In G Protein-Coupled Receptor Signaling in Plants: Methods and Protocols, experts in the field describe techniques used in the study of small GTPases and related proteins. Beginning with a chapter on bioinformatics approaches for GPCR discovery, this detailed volume continues with chapters on heterotrimeric G protein subunits, Rab-GTPases, as well as lipid modifications, including myristoylation, acylation, and prenylation. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Practical and dependable, G Protein-Coupled Receptor Signaling in Plants: Methods and Protocols aims to aid further studies into the roles of small GTPases which will help elucidate numerous key processes in plants.
- 2006 CRCnetBASEHaga, Tatsuya; Takeda, Shigeki.
- 2006 CRCnetBASEChiu, Mark L.; Lundstrom, Kenneth H.
- 2015 Springer ProtocolsFilizola, Marta.Purification of stabilized GPCRs for structural and biophysical analyses / James C. Errey ... [et al.] -- Purification and crystallization of a thermostabilized agonist-bound conformation of the human adenosine A2A receptor / Christopher G. Tate and Guillaume Lebon -- 2D projection analysis of GPCR complexes by negative stain electron microscopy / Alys Peisley and Georgios Skiniotis -- Nuts and bolts of CF3 and CH3 NMR towards the understanding of conformational exchange of GPCRs / R. Scott Prosser and Tae Hun Kim -- Single-molecule fluorescence microscopy for the analysis of fast receptor dynamics / Julia Wagner ... [et al.] -- Quantitative multi-color detection strategies for bioorthogonally labeled GPCRs / Minyoung Park ... [et al.] -- Approaches to characterize and quantify oligomerization of GPCRs / Sara Marsango, María José Varela, and Graeme Milligan -- Monitoring G protein activation in cells with BRET / Ikuo Masuho, Kirill A. Martemyanov, and Nevin A. Lambert -- Use of fluorescence indicators in receptor ligands / Kaleeckal G. Harikumar and Laurence J. Miller -- Detection and quantification of intracellular signaling using FRET-based biosensors and high content imaging / Michelle L. Halls ... [et al.] -- Measurement of receptor signaling bias / Terry Kenakin -- Approaches to assess functional selectivity in GPCRs : evaluating G protein signaling in an endogenous environment / Laura M. Bohn, Lei Zhou, and Jo-Hao Ho -- Bioluminescence resonance energy transfer approaches to discover bias in GPCR signaling / Elizabeth K. M. Johnstone and Kevin D. G. Pfleger -- Virus-mediated expression of DREADDs for in vivo metabolic studies / Mario Rossi ... [et al.] -- High-throughput screening for allosteric modulators of GPCRs / Robert L. Bertekap Jr. ... [et al.] -- Radioligand binding assay for an exon 11-associated mu opioid receptor target / Gina F. Marrone, Susruta Majumdar, and Gavril W. Pasternak -- Docking and virtual screening strategies for GPCR drug discovery / Thijs Beuming ... [et al.] -- Dynamic process of drug-GPCR binding at either orthosteric or allosteric sites evaluated by metadynamics / Sebastian Schneider, Davide Provasi, and Marta Filizola -- Experiment-guided molecular modeling of protein-protein complexes involving GPCRs / Irina Kufareva, Tracy M. Handel, and Ruben Abagyan -- Interaction fingerprints and their applications to identify hot spots / Andrés F. Marmolejo ... [et al.].
- 2009 Springer ProtocolsLeifert, Wayne R.New insights into GPCR function: implications for HTS / R.M. Eglen and T. Reisine -- Screening technologies for G protein-coupled receptors: from HTS to uHTS / M. De los Frailes and E. Diez -- GPCR signaling: understanding the pathway to successful drug discovery / C. Williams and S.J. Hill -- An overview on GPCRs and drug discovery: structure-based drug design and structural biology on GPCRs / K. Lundstrom -- Understanding the ligand-receptor-G protein ternary complex for GPCR drug discovery / V.R. Ratnala and B. Kobilka -- Assay data quality assessment / H. Gubler -- Homology modeling of GPCRs / J. Simms [and others] -- GPCR expression using baculovirus-infected Sf9 cells / A.L. Aloia [and others] -- Radioligand binding assays: application of [(125)I]angiotensin II receptor binding / W.R. Leifert [and others] -- [35S]GTPgammaS binding in G protein-coupled receptor assays / T. Cooper, E.J. McMurchie and W.R. Leifert -- A time-resolved fluorescent lanthanide (Eu)-GTP binding assay for chemokine receptors as targets in drug discovery / J. Labrecque, R.S. Wong and S.P. Fricker -- Use of the DiscoveRx Hit hunter cAMPII assay for direct measurement of cAMP in Gs and Gi GPCRs / J. Bradley and D. McLoughlin -- Use of aequorin for G protein-coupled receptor hit identification and compound profiling / S.J. Brough and P. Shah -- BacMam: versatile gene delivery technology for GPCR assays / E.A. Davenport, P. Nuthulaganti and R.S. Ames -- Yeast assays for G protein-coupled receptors / S.J. Dowell and A.J. Brown -- GPCR microspot assays on solid substrates / Y. Fang and J. Lahiri -- Resonant waveguide grating biosensor for whole-cell GPCR assays / Y. Fang, A.M. Ferrie and E. Tran -- FRET-based measurement of GPCR conformational changes / S. Granier [and others] -- FLIPR assays of intracellular calcium in GPCR drug discovery / K.B. Hansen and H. Brauner-Osborne -- Use of fluorescence indicators in receptor ligands / K.G. Harikumar and L.J. Miller -- Application of fluorescence resonance energy transfer techniques to establish ligand-receptor orientation / K.G. Harikumar and L.J. Miller -- Detection of GPCR/beta-arrestin interactions in live cells using bioluminescence resonance energy transfer technology / M. Kocan and K.D. Pfleger -- Using reporter gene technologies to detect changes in cAMP as a result of GPCR activation / D.J. Rodrigues and D. McLoughlin -- A quantum dot-labeled ligand-receptor binding assay for G protein-coupled receptors contained in minimally purified membrane nanopatches / J.L. Swift, M.C. Burger and D.T. Cramb -- Xenopus oocyte electrophysiology in GPCR drug discovery / K.B. Hansen and H. Brauner-Osborne -- Immunoprecipitation and phosphorylation of G protein-coupled receptors / W.G. Thomas.
- 2014 SpringerFilizola, Marta.G protein-coupled receptors (GPCRs) are heptahelical transmembrane receptors that convert extra-cellular stimuli into intra-cellular signaling, and ultimately into biological responses. Since GPCRs are natural targets for approximately 40% of all modern medicines, it is not surprising that they have been the subject of intense research. Notwithstanding the amount of data generated over the years, discovering ligands of these receptors with optimal therapeutic properties is not straightforward and has certainly been hampered for years by the lack of high-resolution structural information about these receptors.--Back cover.Also available: Print – 2014
- 2010 SpringerMonti, Jaime M.; Möhler, Hanns; Pandi-Perumal, S. R.Part 1. Basic Physiology and Pharmacology -- Physiology and Pharmacology of the GABA System: Focus on GABA Receptors / Hanns Möhler -- Development of Subtype-Selective GABAA Receptor Compounds for the Treatment of Anxiety, Sleep Disorders and Epilepsy / John R. Atack -- Distribution of GABAA Receptor Subunits in the Human Brain / H. J Waldvogel, K Baer and R. L. M. Faull -- Pharmacokinetic Determinants of the Clinical Effects of Benzodiazepine Agonist Hypnotics / David J. Greenblatt -- Part 2. Sleep Science and Circuitry -- Sleep and Its Modulation by Substances That Affect GABAA Receptor Function / Axel Steiger -- Subcortical Neuromodulation of Feedforward and Feedback Inhibitory Microcircuits by the Reticular Activating System / J. Josh Lawrence -- Function of GABAB and ρ-Containing GABAA Receptors (GABAC Receptors) in the Regulation of Basic and Higher Integrated Sleep-Waking Processes / Claude Gottesmann -- Interactions Between GABAergic and Serotonergic Processes in the Dorsal Raphe Nucleus in the Control of REM Sleep and Wakefulness / Jaime M. Monti -- GABA-ergic Modulation of Pontine Cholinergic and Noradrenergic Neurons for REM Sleep Generation / Dinesh Pal and Birendra Nath Mallick -- Involvement of GABAergic Mechanisms in the Laterodorsal and Pedunculopontine Tegmental Nuclei (LDT-PPT) in the Promotion of REM Sleep / Pablo Torterolo and Giancarlo Vanini -- GABAergic Mechanisms in the Ventral Oral Pontine Tegmentum: The REM Sleep-Induction Site - in the Modulation of Sleep-Wake States / Fernando Reinoso-Suárez, Carmen de la Roza, Margarita L Rodrigo-Angulo, Isabel de Andrés and Ángel Núñez, et al. -- The Role of GABAergic Modulation of Mesopontine Cholinergic Neurotransmission in Rapid Eye Movement (REM) Sleep / Gerald A Marks and Christopher M Sinton -- Melatonin and Sleep: Possible Involvement of GABAergic Mechanisms / Daniel P. Cardinali, S. R. Pandi-Perumal, Lennard P. Niles and Gregory M. Brown -- GABA Involvement in the Circadian Regulation of Sleep / J. Christopher Ehlen, Daniel L. Hummer, Ketema N. Paul and H. Elliott Albers -- Part 3. Neurotherapeutics -- Pathophysiology of Sleep Disorders / Thomas C. Wetter, Pierre A. Beitinger, Marie E. Beitinger and Bastian Wollweber -- Insomnia: Differential Diagnosis and Current Treatment Approach / J. F Pagel and Gerald Kram -- Zolpidem in the Treatment of Adult and Elderly Primary Insomnia Patients / Luc Staner, Françoise Cornette, Sarah Otmani, Jean -François Nedelec and Philippe Danjou -- Efficacy and Safety of Zopiclone and Eszopiclone in the Treatment of Primary and Comorbid Insomnia / Jadwiga S. Najib -- Indiplon / David N. Neubauer -- Polysomnographic and Clinical Assessment of Zaleplon for the Treatment of Primary Insomnia / Joseph Barbera and Colin Shapiro.
- 2007 ScienceDirectAbercrombie, Elizabeth D.; Bolam, J. P.; Tepper, James Michael.Basal ganglia macrocircuits / J. M. Tepper, E. D. Abercrombie and J. P. Bolam -- GABA: homeostatic and pharmacological aspects / A. Schousboe and H. S. Waagepetersen -- GABA [subscript A] receptors: structure and function in the basal ganglia / T. Goetz ... [et al.] -- GABA [subscript B] receptors: structure and function / P. C. Emson -- The cellular, molecular and ionic basis of GABA [subscript A] receptor signalling / M. Farrant and K. Kaila -- GABAergic inhibition in the neostriatum / C. J. Wilson -- Globus pallidus external segment / H. Kita -- Globus pallidus internal segment / A. Nambu -- The pars reticulata of the substantia nigra: a window to basal ganglia output / J. M. Deniau ... [et al.] -- GABAergic control of the subthalamic nucleus / M. D. Bevan, N. E. Hallworth and J. Baufreton -- GABAergic control of substantia nigra dopaminergic neurons / J. M. Tepper and C. R. Lee -- GABAergic output of the basal ganglia / O. Hikosaka -- Localization of GABA receptors in the basal ganglia / J. Boyes and J. P. Bolam -- Presynaptic modulation of GABA release in the basal ganglia / U. Misgeld, G. Drew and Y. Yanovsky -- Development of striatal fast-spiking GABAergic interneurons / M.-F. Chesselet ... [et al.] -- Co-localization of GABA with other neuroactive substances in the basal ganglia / J. F. McGinty -- GABAergic circuits in the basal ganglia and movement disorders / A. Galvan and T. Wichmann -- Simulation of GABA function in the basal ganglia: computational models of GABAergic mechanisms in basal ganglia function / J. R. Wickens, G. W. Arbuthnott and T. Shindou.
- 2007 SpringerEnna, S. J.; Möhler, Hanns.
- 2014 PsychiatryOnlineGabbard, Glen O.Intellectual disability (intellectual developmental disorder) -- Communication disorders -- Autism spectrum disorder -- Attention-deficit/hyperactivity disorder -- Specific learning disorder -- Tic disorders -- Elimination disorders -- Early-stage schizophrenia -- Toward a dimensional understanding of psychosis and its treatment -- Psychosocial treatments for chronic psychosis -- Pharmacological treatment of psychosis -- Psychotherapy of mood disorders -- Acute and maintenance treatment of bipolar and related disorders -- Pharmacological and somatic treatments for major depressive disorder -- Brain stimulation treatments for mood disorders -- Panic disorder -- Separation anxiety disorder -- Social anxiety disorder (social phobia) -- Generalized anxiety disorder -- Specific phobia -- Obsessive-compulsive disorder -- Body dysmorphic disorder -- Hoarding disorder, trichotillomania (hair-pulling disorder), and excoriation (skin-picking) disorder -- Dissociative identity disorder -- Depersonalization/derealization disorder -- Dissociative amnesia -- Posttraumatic stress disorder -- Acute stress disorder -- Adjustment disorders -- Evidence-based psychological treatments for eating disorders -- Pharmacological treatment of eating disorders -- Intensive treatment for eating disorders -- Primary care and consultation-liaison interventions for somatic symptom and related disorders -- Pharmacological interventions for psychosomatic disorders -- Intensive interventions for somatic symptom disorders -- Sleep-wake disorders -- Sexual dysfunctions -- Paraphilias and paraphilic disorders -- Gender dysphoria -- Oppositional defiant disorder -- Intermittent explosive disorder -- Conduct disorder -- With limited prosocial emotions specifier for conduct disorder -- Pyromania -- Kleptomania -- Alcohol-related disorders -- Sedative-, hypnotic-, or anxiolytic-related disorders -- Opioid-related disorders: opioid detoxification -- Opioid-related disorders: antagonist treatment -- Opioid-related disorders: agonist maintenance treatment -- Hallucinogen-related disorders -- Cannabis-related disorders -- Club drug addiciton -- Stimulant-related disorders -- Nicotine-related disorders -- Individual therapy for substance use disorders -- Cognitive, behavioral, and motivational therapies for substance use disorders -- Group therapy for substance use disorders -- Family therapy in substance abuse treatment -- Network therapy for substance use disorders -- Pain and addiction -- Gambling disorder -- Delirium -- Neurocognitive disorder due to Alzheimer's disease -- Frontotemporal neurocognitive disorder -- Vascular neurocognitive disorder -- Neurocognitive disorder due to Parkinson's disease -- Paranoid, schizotypal, and schizoid personality disorders -- Antisocial personality disorder -- Borderline personality disorder -- Histrionic personality disorder -- Narcissistic personality disorder -- Cluster C personality disorders: avoidant, dependent, and obsessive-compulsive.
- 2006/2007Pan, Kuang-Hung.
- 2013 SpringerHoffman, Barbara; Liebermann, Dan A.Emerging evidence indicates that the Gadd45 family of genes play a unique and critical role as sensors of stress, including genotoxic, physiological and oncogenic stress. The stress response Gadd45 family of genes (Gadd45a, Gadd45b & Gadd45g), discovered by Dr. Liebermann and other researchers, encode for small (18 kd) nuclear/cytoplasmic proteins).These genes are rapidly induced by a wide variety of endogenous and exogenous stress stimuli. In spite of marked similarities, Gadd45 genes are regulated differently & exhibit functional diversity. Gadd45 are implicated in cell cycle arrest, DNA demethylation & repair, apoptosis, cell survival, genomic stability, inflammation, & in response to physiological and oncogenic stress. Functions of Gadd45 genes are mediated by protein-protein interactions that modulate structure/function of other cellular proteins implicated in cell cycle regulation and the response of cells to stress; these interactions vary depending upon the biological setting including cell type, developmental stage and stress/stimulus. Protein partners include cdc2/cyclinB1, p21, the p38/JNK stress induced kinase pathways, and PCNA/histones. The purpose of this book is to provide a comprehensive picture of the unique global role Gadd45 genes play as stress sensors & the molecular pathways involved.Also available: Print – 2013
- Gaining access to the hematopoietic stem cell niche : novel non-myeloablative conditioning approaches2010Czechowicz, Agnieszka; Crabtree, Gerald R.; Shizuru, Judith A.; Weissman, Irving L.Sickle Cell Anemia, Beta Thalassemia, Severe Combined Immunodeficiency (SCID), and Type I Diabetes share one commonality: these diverse disorders can all be attributed to faulty hematolymphoid effector cells which are largely caused by genetic mutations that alter hematopoietic cell-intrinsic function. These defective blood cells inherit their genetic deficiencies from hematopoietic stem cells (HSC) as they differentiate. Thus, each of these unique diseases should be theoretically curable through the same strategy: replacement of patients' HSCs carrying the problematic mutation with normal HSCs from disease-free donors, thereby generating entire new, healthy hematolymphoid systems. Replacement of disease-causing stem cells with healthy ones has been achieved clinically via hematopoietic cell transplantation (HCT) for the last 50 years, as a treatment modality for a variety of cancers and immunodeficiencies with moderate, but increasing success. However this technique bears high morbidity and mortality severely limiting its utilization. Purified hematopoietic stem cell transplantation is associated with high toxicity primarily attributed to the myeloablative pre-conditioning necessary to facilitate engraftment of the donor HSCs. However the function and mechanistic role of these reagents has been up until now poorly understood. This thesis deconstructs the current barriers in HCT and pure HSC transplantation, and suggests that in addition to the immune barrier, hematopoietic stem cell niche availability is another critical obstacle that needs to be overcome to allow for efficient hematolymphoid replacement. In this thesis I show that in the homeostatic state, most hematopoietic stem cell niches are occupied by host HSCs limiting the ability of incoming HSC engraftment. However, a limited number of HSC niches are vacated by HSC that are egressing from the peripheral blood into the bone marrow in a division independent manner, allowing for true but minimal HSC engraftment without myeloablative pre-conditioning. This thesis illustrates new, up-and-coming strategies to combat the obstacle of HSC niche availability. Here I prove that one non-myeloablative conditioning approach that capitalizes upon physiological HSC egress is repetitive transplantation of purified HSCs. However, this approach is rather laborious and inefficient, and I show that another more efficient novel non-myeloablative conditioning approach to vacate the HSC niche is antibody-mediated depletion of host HSCs. Furthermore, in this thesis I demonstrate that antibody-mediated inhibition of c-kit effectively depletes host HSCs and allows for efficient, non-toxic HSC transplantation. These novel non-myeloablative conditioning methods illustrate new means of overcoming the current barriers to hematolymphoid replacement thereby allowing for the potential expansion of this technique to treat a variety of inherited diseases of hematopoietic and immune function.
- 2007Whittle, Michael.
- 2010Perry, Jacquelin; Burnfield, Judith M.Gait cycle -- Phases of gait -- Basic functions -- Ankle-foot complex -- Knee -- Hip -- Head, trunk, and pelvis -- Arm -- Total limb function and bilateral synergistic relationships -- Pathological mechanisms -- Ankle and foot gait deviations -- Knee gait deviations -- Hip gait deviations -- Trunk and pelvis gait deviations -- Examples of pathologic gait -- Pediatric gait analysis / Henry G. Chambers -- Stair negotiation -- Running / Marilyn M. Pink -- Gait analysis systems -- Motion analysis -- Muscle control and dynamic electromyography -- Kinetics of gait : ground reaction forces, vectors, moments, power, and pressure -- Stride analysis -- Energy expenditure / Robert Waters.
- 2011Chávez-Clemente, Daniel; Fong, Terrence W.; Gerdes, J. Christian; Latombe, Jean-Claude; Rock, Stephen M.The interest in using legged robots for a variety of terrestrial and space applications has grown steadily since the 1960s. At the present time, a large fraction of these robots relies on electric motors at the joints to achieve mobility. The load distributions inherent to walking, coupled with design constraints, can cause the motors to operate near their maximum torque capabilities or even reach saturation. This is especially true in applications like space exploration, where critical mass and power constraints limit the size of the actuators. Consequently, these robots can benefit greatly from motion optimization algorithms that guarantee successful walking with maximum margin to saturation. Previous gait optimization techniques have emphasized minimization of power requirements, but have not addressed the problem of saturation directly. This dissertation describes gait optimization techniques specifically designed to enable operation as far as possible from saturation during walking. The benefits include increasing the payload mass, preserving actuation capabilities to react to unforeseen events, preventing damage to hardware due to excessive loading, and reducing the size of the motors. The techniques developed in this work follow the approach of optimizing a reference gait one move at a time. As a result, they are applicable to a large variety of purpose-specific gaits, as well as to the more general problem of single pose optimization for multi-limbed walking and climbing robots. The first part of this work explores a zero-interaction technique that was formulated to increase the margin to saturation through optimal displacements of the robot's body in 3D space. Zero-interaction occurs when the robot applies forces only to sustain its weight, without squeezing the ground. The optimization presented here produces a swaying motion of the body while preserving the original footfall locations. Optimal displacements are found by solving a nonlinear optimization problem using sequential quadratic programming (SQP). Improvements of over 20% in the margin to saturation throughout the gait were achieved with this approach in simulation and experiments. The zero-interaction technique is the safest in the absence of precise knowledge of the contact mechanical properties and friction coefficients. The second part of the dissertation presents a technique that uses the null space of contact forces to achieve greater saturation margins. Interaction forces can significantly contribute to saturation prevention by redirecting the net contact force relative to critical joints. A method to obtain the optimal distribution of forces for a given pose via linear programming (LP) is presented. This can be applied directly to the reference gait, or combined with swaying motion. Improvements of up to 60% were observed in simulation by combining the null space with sway. The zero-interaction technique was implemented and validated on the All Terrain Hex-Limbed Extra-Terrestrial Explorer (ATHLETE), a hexapod robot developed by NASA for the transport of heavy cargo on the surface of the moon. Experiments with ATHLETE were conducted at the Jet Propulsion Laboratory in Pasadena, California, confirming the benefits predicted in simulation. The results of these experiments are also presented and discussed in this dissertation.
- Gaither's Dictionary of scientific quotations : a collection of quotations pertaining to archaeology, architecture, astronomy, biology, botany, chemistry, cosmology, Darwinism, death, engineering, geology, life, mathematics, medicine, nature, nursing, paleontology, philosophy, physics, probability, science, statistics, technology, theory, universe, and zoology2008 SpringerGaither, Carl C.; Cavazos-Gaither, Alma E.v. 1. Abortion-medical science -- v. 2. Medicine and art--zoology.
- 2010 SpringerHökfelt, T.Galanin : a multitalented neuropeptide / T. Hökfelt and K. Tatemoto -- Galanin, galanin receptors, and drug targets / K. Mitsukawa, X. Lu, and T. Bartfai -- Galanin acts as a trophic factor to the central and peripheral nervous systems / S-A. Hobson ... [et al.] -- Galanin and spinal pain mechanisms : past, present, and future / Xiao-Jun Xu, Tomas Hökfelt, and Zsuzsanna Wiesenfeld-Hallin -- Galanin family of peptides in skin function / J.W. Bauer ... [et al.] -- Galanin in glia : expression and potential roles in the CNS / Helmut Butzkueven and Andrew L. Gundlach -- Galanin and the neuroendocrine axes / Istvan Merchenthaler -- Galanin and consummatory behavior : special relationship with dietary fat, alcohol, and circulating lipids / Jessica R. Barson, Irene Morganstern, and Sarah F. Leibowitz -- Neurochemical modulation of central cardiovascular control : the integrative role of galanin / Zaida Díaz Cabiale ... [et al.] -- Galanin impairs cognitive abilities in rodents : relevance to Alzheimer's disease / J.N. Crawley -- Neuroprotective role for galanin in Alzheimer's disease / Scott E. Counts ... [et al.] -- Galanin, galanin receptor subtypes, and depression-like behaviour / Eugenia Kuteeva ... [et al.] -- Galanin and epilepsy / J.T. Lerner, R. Sankar, and A.M. Mazarati -- Galanin and addiction / Marina R. Picciotto -- Galanin systems and ischemia : peptide and receptor plasticity in neurons and oligodendroglial precursors / Pei-Juan Shen and Andrew L. Gundlach -- The galanin system in cancer / I. Rauch and Barbara Kofler -- Galanin systems in non-mammalian vertebrates with special focus on fishes / Elsie Tachie Mensah, Helene Volkoff, and Suraj Unniappan -- Galanin-like peptide : neural regulator of energy homeostasis and reproduction / Catherine B. Lawrence and Gregory S. Fraley.
- Galen, De diebus decretoriis, from Greek into Arabic : a critical edition, with translation and commentary, of Ḥunayn ibn Isḥāq, Kitāb ayyām al-buḥrānGalen; Ḥunayn ibn Isḥāq al-ʻIbādī; Cooper, Glen Michael.
- 2014 SpringerHuang, He-Feng; Sheng, Jian-Zhong.The book Gamete and Embryo-fetal Origins of Adult Diseases introduces various diseases resulting from the abnormal gametogenesis and embryo development, which manifests as growth retardation, birth defects, or increased susceptibility to chronic metabolic diseases such as diabetes, cardiovascular disease and cancer in childhood and adult life, even fertility disorders and the risk of transgenerational transmission. Six common kinds of these diseases are discussed in separate chapters. The authors explore the connections between these diseases and epigenetic reprogramming, rapid cell differentiation and organ formation and environmental influences, including assisted reproductive technology and adverse intrauterine environments. With a summary of findings on the causes and progression of adult diseases at the phase of gametogenesis and embryo development, this book provides insights into the pathogenesis of disease and aids in the treatment and prevention of disease, meeting the requirement for improving the quality of the newborn population, and effectively preventing and curing major diseases at an early stage. This book offers new perspectives and will be an enlightening resource for obstetricians, paediatricians, epidemiologists, endocrinologists and sanitarians.
- 2013 SpringerBrevini, Tiziana A. L.; Pennarossa, Georgia.This Brief offers a concise, handy overview of the main concepts related to Embryology, revisited through the novel concepts that are applied daily in stem cell research and cell therapy oriented investigations. It is based on three main areas: -The process involved in female gamete differentiation and maturation. The main aspects related to cell biology will be covered and an overview of the epigenetic regulation of gametogenesis will be presented. -Early stages of embryo development with a careful analysis of the regulatory mechanisms driving cleavage, polarization and genome activation. -Stem cell and gametogenesis. The use of the oocyte as a possible source for the derivation of stem cell lines is discussed and depicted as a powerful tool to investigate oocyte potency and asymmetric imprinting. The potential biological implications are evaluated and use of stem cells to derive oocytes is presented.
- 2011 SpringerGanz, Jeremy C.Introduction and the nature of radiosurgery -- Principles of stereotaxy -- Ionizing radiation and its effects on living tissue -- Biological effects of ionizing radiation -- Ionizing radiation and clinical practice -- Gamma knife development from 1967 to 2010 -- Radiophysics, radiobiology and the gamma knife -- Preparation for treatment planning -- Dose plan indices -- Gamma knife surgery and computer networks -- Aims of gamma knife surgery -- Principles of information and follow up -- Vestibular schwannomas -- Meningiomas -- Gamma knife for cerebral metastases -- Intraparenchymal intrinsic brain tumors -- Tumors of the pituitary region -- Less common skull base tumors -- Gamma knife for cerebral vascular anomalies -- Trigeminal neuralgia -- Diverse functional indications -- Rare tumors and other lesions -- Orbital indications -- Conclusion and possible future trends.
- 2013 SpringerChernov, Mikhail F.The articles in this volume cover the various options of the optimal management of brain tumors, vascular lesions, and functional disorders. They provide a good balance between microneurosurgery and radiosurgery, presenting also alternative surgical and radiosurgical treatment options with discussions on their advantages and disadvantages. The presentation of multiple treatment methods will help to provide better service to patients. Some papers, specifically highlighting alternative treatment options, are accompanied by editorials prepared by recognized experts in the field. Additional emphasis is put on importance of the advanced neuroimaging techniques for radiosurgical treatment planning and subsequent follow-up.
- 2013 KargerKano, Hideyuki; Lunsford, L. Dade; Niranjan, Ajay.A brief history of arteriovenous malformation radiosurgery / A. Niranjan, L.D. Lunsford -- Natural history of cerebral arteriovenous malformations and the risk of hemorrhage after radiosurgery / C.-P. Yen, D. Schlesinger, J.P. Sheehan -- The technical evolution of gamma knife radiosurgery for arteriovenous malformations / L.D. Lunsford ... [et al.] -- Targeting and conformality in arteriovenous malformation radiosurgery / I. Paddick, E. Motti -- Dose selection in stereotactic radiosurgery / J.C. Flickinger ... [et al.] -- Development and testing of a radiosurgery-based arteriovenous malformation grading system B.E. Pollock -- Radiosurgery for brainstem arteriovenous malformation / K. Maruyama ... [et al.] -- Multistaged volumetric management of large arteriovenous malformations / H. Kano -- Endovascular embolization in combination with radiosurgery for treatment of arteriovenous malformations / R.A. Miller, B. Jankowitz -- Stereotactic radiosurgery after embolization for arteriovenous malformations / H. Kano -- Long-term side effects of radiosurgery for arteriovenous malformations / M. Yamamoto, T. Kawabe, B.E. Barfod -- Management of adverse radiatio effects after radiosurgery for arteriovenous malformations / E.A. Monaco -- Morphological observations in brain arteriovenous malformations after gamma knife radiosurgery / G.T. Szeifert -- Stereotactic radiosurgery guideline for the management of patients with intracranial arteriovenous malformations / A. Niranjan, L.D. Lunsford -- Cavernous malformations and hemorrhage risk / D. Kondziolka, E.A. Monaco, III, L.D. Lunsford -- Radiosurgery of brain cavernomas : long-term results / R. Liscak -- Radiosurgical treatment for epilepsy associated with cavernomas / M. Lévêque -- Stereotactic radiosurgery guidelines for the management of patients with intracranial cavernous malformations / A. Niranjan, L.D. Lunsford -- Intracranial dural arteriovenous fistulas : natural history and rationale for treatment with stereotactic radiosurgery / D.H.-C. Pan ... [et al.] -- Stereotactic radiosurgery with or without embolization for intracranial dural arteriovenous fistulas / H. Yang -- Dural arteriovenous fistulas and the role of gamma knife stereotactic radiosurgery : the Stockholm experience / M. Söderman, E. Dodoo, B. Karlsson -- Stereotactic radiosurgery guidelines for the management of patients with intracranial dural arteriovenous fistulas / A. Niranjan, L.D. Lunsford.
- 2001 KargerBergstresser, Paul R.; Takashima, A.T cell receptor and function cosegregate in gamma-delta T cell subsets -- Role of the IL-7 receptor in gamma-delta T cell development -- Epidermal and dermal gamma-delta T cells -- Cytokine profiles and responsiveness of dendritic epidermal T cells: cytokine-mediated communication with other cells -- Gamma-delta T cells with emphasis on their functional role in the epidermis -- Role of gamma-delta T cells in cutaneous hypersensitivity reactions -- Gamma-delta T cells: immunoregulatory functions and immunoprotectionAlso available: Print – 2001
- 2013 SpringerCastellano, Immacolata; Merlino, Antonello.Gamma-Glutamyl Transpeptidases (g-GTs) are members of the N-terminal nucleophile hydrolase superfamily, enzymes that cleave the g-glutamyl amide bond of glutathione to liberate cysteinylglycine. The released g-glutamyl group can be transferred to water (hydrolysis) or to amino acids or short peptides (transpeptidation). g-GT plays a key role in the gamma glutamyl cycle by regulating the cellular levels of the antioxidant glutathione, hence it is a critical enzyme in maintaining cellular redox homeostasis.g-GT is upregulated during inflammation and in several human tumors, and it is involved in many physiological disorders related to oxidative stress, such as Parkinson's disease and diabetes. Furthermore, this enzyme is used as a marker of liver disease and cancer. This book covers current knowledge about the structure-function relationship of g-GTs and gives information about applications of g-GTs in different fields ranging from clinical biochemistry to biotechnology and biomedicine.
- v. 1, 1966.Karczmar, A. G.; Volle, R. L.v. 1. Muscarinic and nicotinic stimulant actions at autonomic ganglia, by R. L. Volle.
- 2013Gantz, Nelson M.; Moorman, Jonathan P.; Myers, James W.; Salgado, Cassandra.
- 2005 SpringerWinterhager, Elke.
- 2013 SpringerSeidler, Norbert W.Also available: Print – 2013
- 2015 SpringerKihara, Kazunori.Chapter 1. Fundamentals of Gasless Single-Port RoboSurgeon Surgery -- Chapter 2. Gasless Single-Port RoboSurgeon Retroperitoneoscopic Radical Nephrectomy -- Chapter 3. Gasless Single-Port RoboSurgeon Retroperitoneoscopic Partial Nephrectomy -- Chapter 4. Gasless Two-Port Access RoboSurgeon Retroperitoneoscopic Radical Nephroureterectomy -- Chapter 5. Gasless Single-Port RoboSurgeon Retroperitoneoscopic Adrenalectomy -- Chapter 6. Gasless Single-Port RoboSurgeon Retroperitoneoscopic Radical Prostatectomy -- Chapter 7. Gasless Single-Port RoboSurgeon Total Cystectomy with Urinary Diversion -- Chapter 8. Gasless Single-Port RoboSurgeon Partial Cystectomy: A Hybrid Technique Combining an Intravesical and Extravesical approach -- Chapter 9. Gasless Single-Port RoboSurgeon Retroperitoneoscopic Pelvic Lymph Node Dissection and Inguinal Hernia Prevention -- Chapter 10. Application of the RoboSurgeon System in Medical Care.
- 2012 SpringerHermann, Anton; Sitdikova, Guzel F.; Weiger, Thomas M."The gases termed gasotransmitters play an increasingly important role in understanding how signalling into and between cells is modulated and fine-tuned. The advent of gasotransmitters has profoundly changed our way of thinking about biosynthesis, liberation, storage and action mechanisms in cellular signaling. In recent years an impressive amount of new data, distributed throughout the existing literature, has been generated. For this book the editors have recruited distinguished colleagues in the field to summarize and review important biological, pharmacological and medical functions and their implications, as well as methods for the detection of gasotransmitters."--P.  of cover.
- v.1-2=, 2012 ClinicalKeyAgarwal, Anita; Gass, J. Donald M.v. 1. Normal macula -- Imaging and electrophysiological studies -- Diseases causing exudative and hemorrhagic detachment of the choroid, retina and retinal pigment epithelium -- Folds of the choroid and retina -- Heredodystrophic disorders affecting the pigment epithelium and retina -- Macular dysfunction caused by retinal vascular diseases -- Macular dysfunction caused by vitreous and vitreoretinal interface abnormalities -- Traumatic retinopathy -- v. 2. Toxic diseases affecting the pigment epithelium and retina -- Infectious diseases of the retina and choroid -- Inflammatory diseases of the retina -- Tumors of the retinal pigment epithelium (RPE) -- Neoplastic diseases of the retina -- Neoplastic diseases of the choroid -- Optic nerve diseases that may masquerade as macular diseases.
- 2015 SpringerStrong, Vivian E.The Historical Perspective of Gastric Cancer -- Epidemiology of Gastric Cancer -- Molecular Mechanisms in Gastric Carcinogenesis -- Pathology of Gastric Cancer -- Role of HER2 in Gastric Cancers -- Pathophysiology of Hereditary Diffuse Gastric Cancer -- Western Perspective and Epidemiology of Gastric Cancer -- Diagnosis, Staging and Workup of Gastric Cancer -- Endoscopy and Endoscopic Ultrasound Examination of the Stomach -- The Role of Staging Laparoscopy and Peritoneal Cytology in Gastric Cancer -- Endoscopic Resection for Gastric Cancer -- Methods of Reconstruction -- BI, BII, Roux-en-Y, Jejunal Interposition, Proximal Gastrectomy and Pouch Reconstruction -- Lymphadenectomy -- D1, D2 and D3 -- Open Methods of Resection and Reconstruction for Subtotal and Total Gastrectomy -- Laparoscopic Methods of Resection and Reconstruction for Subtotal and Total Gastrectomy with D2 Lymphadenectomy -- Robotic Methods of Resection and Reconstruction for Subtotal and Total Gastrectomy with D2 Lymphadenectomy -- Managing Early and Late Postoperative Complications Following Gastric Surgery -- Hereditary Diffuse Gastric Cancer -- Surveillance after Gastric Resection -- Surgical Trials for Gastric Cancer -- Neoadjuvant and Adjuvant Treatment -- Strategies and Clinical Trials -- Western Perspective -- Adjuvant and Neoadjuvant Treatment: Standard Treatment and Clinical Trials in the East -- Radiation Treatment for Gastric Cancer -- Targeted Therapy and Novel Agents for the Treatment of Gastric Cancer: A View towards the Future.
- 2012 ScienceDirect2012 ClinicalKeyNeu, Josef.Overview of digestion and absorption / Josef Neu -- Maturation of motor function in the preterm infant and gastroesophageal reflux / Anna Marla Hibbs -- Development of gastrointestinal motility reflexes / Sudarshan Rao Jadcherla -- Development of the intestinal mucosal barrier / Allan Walker and Camilia Martin -- The developing intestinal microbiome and its relationship to health and disease / Josef Neu -- The developing intestine as an immune organ / Patricia Lin -- The developing gastrointestinal tract in relation to autoimmune disease, allergy, and atopy / Outi Vaarala -- What are the controversies for basic intestinal development and where will the field be moving in the future? / Josef Neu -- Nutritional requirements of the very-low-birthweight infant / Patti Thureen and William Hay Jr. -- Controversies in neonatal nutrition : macronutrients and micronutrients / Frank R. Greer -- Regulation of protein synthesis and proteolysis in the neonate by feeding / Tracy Gautsch Anthony and Susan Hazels Mitmesser -- Lipids for neonates / Sheila M. Innis -- Human milk feeding of the high-risk neonate / Christina Valentine -- Nutritional requirements for the neonate : what are the controversies and where will the field be moving in the future? / Josef Neu -- Necrotizing enterocolitis / Josef Neu -- Special nutrition of the surgical neonate / Tom Jaksic -- Controversies in short bowel syndrome / Marc Rhoads -- Neonatal cholestasis / Joel Andres -- The neonatal gastrointestinal tract as a conduit to systemic inflammation and developmental delays / Josef Neu and James Wynn -- Adult consequences of neonatal and fetal nutrition : mechanisms / Robert Lane -- Technologies for the evaluation of enteral feeding readiness in premature infants / Josef Neu -- What are the controversies for these clinical conditions and where will the field be moving in the future? / Josef Neu.
- 2013 SpringerMeyer, Keith C.; Raghu, Ganesh.Deglutition, Swallowing, and Airway Protection: Physiology and Pathophysiology / Jacqui E. Allen -- The Pathophysiology of Gastroesophageal Reflux / Nikki Johnston -- Making an Accurate Diagnosis of GERD / Edward D. Auyang and Brant K. Oelschlager -- GER and Aspiration in Children / Jonathan E. Spahr and Raymond C. Maguire -- Dysphagia, GER, and Aspiration in the Elderly / Joshua Malo, Kenneth S. Knox and Ronnie Fass -- Chronic Cough and Vocal Cord Dysfunction: The Role of GER / Jamal Hayat, Etsuro Yazaki and Daniel Sifrim -- GER in Asthma and COPD / Bindu Akkanti and Nicola A. Hanania -- Sleep and GER / Susan M. Harding -- Gastroesophageal Reflux in Cystic Fibrosis and Non-CF Bronchiectasis / Ans Pauwels, Daniel Sifrim and Lieven Dupont -- GER and Aspiration in Interstitial Lung Disease / Keith C. Meyer and Ganesh Raghu -- GER in Lung Transplantation / Keith C. Meyer and James D. Maloney -- Pharmacologic Treatment of GERD / Eric Alan Gaumnitz -- Surgical and Endoscopic Approaches to GERD / Marcelo W. Hinojosa and Carlos A. Pellegrini.
- 2006 SpringerGranderath, Frank A.; Kamolz, Thomas; Pointner, Rudolph.
- 2007Bellamy, Mark C.; Kumar, Chandra M.
- 2012 CRCnetBASEMatarese, Laura E.; Mullin, Gerard E.; Palmer, Melissa."Presents the nutritional consequences and considerations of digestive disorders. Examines the role of nutrition in gastrointestinal and liver disease, including alcoholic and nonalcoholic liver disease, viral hepatitis, cirrhosis, malabsorption, colorectal disease, transplantation, pancreatitis, and inflammatory bowel disease. Includes chapters on food allergy and intolerance, the effects of medicinal plants, and the role of fiber in the gastrointestinal tract. Addresses the challenges of managing nutritional issues for hospitalized patients, and covers eating disorders and ethical issues."--Excerpted from abstract provided by publisher.
- 2012 ClinicalKeyIacobuzio-Donahue, Christine A.; Montgomery, Elizabeth.Non-neoplastic disorders of the esophagus -- Tumors of the esophagus -- Non-neoplastic disorders of the stomach -- Epithelial neoplasms of the stomach -- Non-neoplastic and inflammatory disorders of the small bowel -- Neoplasms of the small intestine -- Gastrointestinal mesenchymal tumors -- Non-neoplastic and neoplastic disorders of the appendix -- Infectious diseases of the colon -- Idiopathic inflammatory bowel disease -- Inflammatory/descriptive/iatrogenic colitides -- Gastrointestinal polyposis syndromes -- Epithelial neoplasms of the colorectum -- Molecular diagnostics in gastrointestinal pathology -- Pathology of the anus -- Pathology of the gallbladder and extrahepatic bile ducts -- Non-neoplastic and neoplastic pathology of the pancreas -- Metabolic and toxic conditions of the liver -- Inflammatory and infectious diseases of the liver -- Liver neoplasms -- Gastrointestinal lymphoma.
- 2010 SpringerBranch, Malcolm Stanley; Pappas, Theodore N.; Pryor, Aurora D.Part 1. Upper GI Bleeding -- Stabilization of Patients Presenting with Upper Gastrointestinal Bleeding / Errol L. Bush and Mark L. Shapiro -- Urgent Workup for Upper Gastrointestinal Bleeding / Loretta Erhunmwunsee and Sandhya A. Lagoo-Deenadayalan -- Management of Esophageal Variceal Bleeding / Keki Balsara and Lisa Pickett -- Management of Dieulafoy's Lesions / Seraina K. Faes, Brian R. Untch, Claire Edwards, John Turner and Martin Poleski, et al. -- Management of Bleeding Peptic Ulcer Disease / James C. Padussis and Theodore N. Pappas -- Management of Unusual Sources of Upper GI Bleeding / Elisabeth Tracy and Janet Tuttle-Newhall -- Mallory-Weiss Syndrome / Jacob N. Schroder and Malcolm S. Branch -- Management of Bleeding Small Bowel Tumors / Keri E. Lunsford and Aurora D. Pryor -- Management of Bleeding from the Bile Duct / Carlos E. Marroquin and Bridget M. Marroquin -- Management of Bleeding from the Pancreas / Eugene P. Ceppa and Dana Portenier -- Part 2. Lower GI Bleeding -- Urgent Workup of Lower GI Bleeding / Dawn M. Emick and Leila Mureebe -- Bleeding Hemorrhoids / Kelley A. Hutcheson and Danny O. Jacobs -- Management of Bleeding Colitis and Colonic Diverticular Disease / Sebastian G. de la Fuente, Hardeep S. Ahluwalia, Alex Perez and John Migaly -- Colonic Arteriovenous Malformations / Sebastian G. de la Fuente and Christopher R. Mantyh -- Bleeding Colonic Tumors / Vanessa A. Olcese and Christopher R. Mantyh -- Part 3. GI Bleeding from an Unknown Source -- Evaluation of the Guaiac Positive Patient / Rebecca Burbridge and Melissa Teitelman -- Obscure GI Bleeding: Capsule and Double-Balloon Techniques / Stephen Philcox -- Provocative Angiography / Mayur B. Patel, Charles Y. Kim and Michael J. Miller -- The Unstable Patient with Obscure Gastrointestinal Bleeding: Surgical and Non-surgical Management / Rebecca P. Petersen and Aurora D. Pryor .
- 2005 SpringerAjani, Jaffer A.; Curley, Steven A.; Janjan, Nora A.
- 2009 SpringerFujita, Rikiya; Takahashi, Hiroshi.
- 2008 SpringerHayat, M. A.
- 2015 SpringerJonnalagadda, Sreeni.This comprehensive treatise on cutting edge tools and research provides a fascinating insight into the rapidly evolving field of diagnostic and therapeutic endoscopy. Accomplished international researchers and clinicians discuss the latest endoscopic advances in diverse areas including obesity and associated metabolic syndromes, management of peripancreatic fluid collections, endoluminal suturing techniques, fistula closure, management of Barrettℓ́ℓs epithelium, cholangioscopy, chromoendoscopy, high resolution manometry and endoscopic ultrasonography. Gastrointestinal Endoscopy: New Technologies and Changing Paradigms is a valuable resource on the evolving role of endoscopic management of gastrointestinal diseases and is a tremendous resource for gastroenterologists, endoscopists, GI surgeons, and medical residents.
- 2011 ScienceDirect2011 ClinicalKeyCanard, Jean Marc.Introduction to endoscopy -- Preparation for Endoscopy -- Diagnostic Upper Endoscopy -- 4 Diagnostic Colonoscopy -- 5 Small Bowel Endoscopy: Indications and Technique -- Advanced Imaging -- Interventional Endoscopy -- Complications of Gastrointestinal Endoscopy -- Endosonography -- Endoscopic Retrograde Cholangiopancreatography.
- 2008 Thieme BookBrambs, Hans-Juergen.Liver -- Gallbladder and biliary tract -- Pancreas -- Gastrointestinal tract (general) -- Esophagus -- Stomach and duodenum -- Small bowel -- Colon and anus -- Abdominal cavity.
- 2011 Thieme BookLorenz, Jonathan.Indhold: RadCases contains cases selected to simulate everything that you'll see on your rounds, rotations, and exams. RadCases also helps you identify the correct differential diagnosis for each case - including the most critical. Each RadCases title features 100 carefully selected, must-know cases documented with clear, high-quality radiographs. The organization provides maximum ease of use for self-assessment.Each case begins with the clinical presentation on the right-hand page; simply turn the page for imaging findings, differential diagnoses, the definitive diagnosis, essential facts, and more. Each RadCases title includes a scratch-off code that allows 12 months of access to a searchable online database of all 100 cases from the book plus an additional 150 cases in that book's specialty - 250 cases in total.
- 2008Halpert, Robert D.
- 2014 ClinicalKeyBoland, Giles W. L.Get the essential tools you need to make an accurate diagnosis with Gastrointestinal Imaging, 4th Edition! Edited by Giles W. Boland, MD, this popular volume in The Requisites Series delivers the conceptual, factual, and interpretive information you need for effective clinical practice in gastrointestinal imaging. Master core knowledge the easy and affordable way with clear, concise text; new, high-quality images, and coverage of the latest modalities. Efficiently and affordably prepare for the written board exam and for clinical practice with focused, high-yield, richly illustrated coverage of the most essential concepts in gastrointestinal imaging.
- 2006Halpert, Robert D.
- 2012 ClinicalKeyLow, Vincent H. S.Gastrointestinal Imaging: Case Review, by Vincent Low, MD, FRANZCR, tests your ability to interpret a wide range of images seen in practice. The completely revised edition of this medical reference title in the popular Case Review series features - 200 cases - organized by difficulty - and 400 images available online at www.casereviewsonline.com, with questions and answers, diagnoses, commentary, and references. It is ideal for quick reference and easy board review! Study effectively with content that mimics the new format of board exams as well as the everyday clinical experience - offering highly effective preparation for certification, recertification, and practice. Spend less time searching and more time learning with easy-to-navigate chapters focused on visual identification and diagnosis, and reorganized by degree of case difficulty and then by body part within each category. Stay current with the most recent findings and advancements in gastrointestinal radiology.
- FRANZCR, Vincent Low.
- Halpert, Robert D.
- 2002 KargerCho, C.-H; Wang, J.-Y.
- 2011 SpringerBlanke, Charles D.; Rödel, Claus; Talamonti, Mark S.PET Physics and Instrumentation / Brad Kemp -- PET Radiochemistry and Radiopharmacy / Mark S. Jacobson, Raymond A. Steichen and Patrick J. Peller -- PET/CT Interpretation / Patrick J. Peller -- Central Nervous System / Jeffrey A. Miller and Terence Z. Wong -- Head and Neck / Rathan M. Subramaniam, J. M. Davison, Ujas Parikh and M. Abou-Zied -- Chest / Rathan M. Subramaniam, J. M. Davison, D. S. Surasi, Gregory Russo and P. J. Peller -- Breast Cancer / Gustavo A. Mercier, Felix-Nicolas Roy and François Bénard -- Gastrointestinal / Roland Hustinx -- Genitourinary / Jacqueline Brunetti and Patrick J. Peller -- Gynecologic / Patrick J. Peller -- Musculoskeletal / Jeffrey J. Peterson -- Hematology / Rathan M. Subramaniam, Leonne Prompers, A. Agarwal, Ali Guermazi and Felix M. Mottaghy -- Dermatological / David Brandon and Bruce Barron -- Pediatric / Hossein Jadvar, Frederic H. Fahey and Barry L. Shulkin -- Assessment of Response to Therapy / Ali Gholamrezanezhad, Alin Chirindel and Rathan Subramaniam -- Metastatic Disease / Patrick J. Peller -- Radiotherapy Planning / Minh Tam Truong and Rathan M. Subramaniam -- Patients with HIV / Rathan M. Subramaniam, J. M. Davison, Devaki S. Surasi, T. Jackson and T. Cooley -- Pitfalls and Artifacts / Geoffrey Bates Johnson and Christopher Harker Hunt.
- 2008 OvidFenoglio-Preiser, Cecilia M.; Isaacson, Peter G.; Lantz, Patrick E.; Noffsinger, Amy E.; Stemmermann, Grant N.General features of the gastrointestinal tract and evaluation of specimens derived from it -- The nonneoplastic esophagus -- The neoplastic esophagus -- The nonneoplastic stomach -- The neoplastic stomach -- The nonneoplastic small intestine -- Epithelial tumors of the small intestine -- Nonneoplastic diseases of the appendix -- The neoplastic appendix -- Motility disorders -- Inflammatory bowel disease -- Polyposis and hereditary cancer syndromes -- The nonneoplastic colon -- Epithelial neoplasms of the colon -- The nonneoplastic anus -- Neoplastic lesions of the anus -- Gastrointestinal neuroendocrine lesions -- Lymphoproliferative disorders of the gastrointestinal tract -- Mesenchymal tumors.Also available: Print – 2008
- 2006 AccessMedicineBarrett, Kim E.Functional anatomy of the GI tract and organs draining into it -- Neurohumoral regulation of gastrointestinal function -- Gastric secretion -- Pancreatic and salivary secretion -- Water and electrolyte absorption and secretion -- Intestinal mucosal immunology and ecology -- Esophageal motility -- Gastric motility -- Intestinal motility -- Functional anatomy of the liver and biliary system -- Bile formation and secretion -- Gallbladder function -- Bilirubin formation and excretion by the liver -- Ammonia and urea -- Carbohydrate, protein and water soluble vitamin assimilation -- Lipid assimilation.
- 2014 SpringerTrowers, Eugene; Tischler, Marc E.This volume provides a practical hands on guide to gastrointestinal physiology. The book emphasizes an appreciation of basic physiological concepts and their application to novel clinical situations. It exposes the physician-in-training to fundamental principles that are useful in treating patients and lays the groundwork for more advanced study in the future. The authors present relevant cases which incorporate newer adult learning strategies in medical education. These cases provide a forum in which the student can apply acquired knowledge, skills and attitudes. Connections are made to reader's life, whether in the classroom, on the wards or out and about town. Designed for medical students who are studying gastrointestinal physiology for the first time, Gastrointestinal Physiology: A Clinical Approach provides a superb review for upper level medical students and house officers. Nursing and allied health professions students will also find this text to be a useful guide. GI fellows and attending physicians in need of a concise review of fundamental GI physiology principles will also benefit from reading this book.
- 2013 ClinicalKeyJohnson, Leonard R.Gastrointestinal Physiology, a volume in the Mosby Physiology Monograph Series, explains the fundamentals of gastrointestinal physiology in a clear and concise manner. Ideal for your systems-based curriculum, this fully updated medical textbook provides you with a basic understanding of how the GI system functions in both health and disease. New to this edition: Stay abreast of the latest research and findings in physiology with coverage of the physiological significance of gastrointestinal peptides; the regulation of mucosal growth and cancer; details surrounding acid secretion and peptic ulcers; and more. Access new gastrointestinal information on the regulation of pancreatic secretion and gallbladder contraction; the transport processes for the absorption of nutrients; facts about fat absorption; and the regulation of food intake.Also available: Print – 2014
- 2014 AccessMedicineBarrett, Kim E.Gastrointestinal Physiology explains the operation and performance of one of the body's most crucial systems. Using clear, compelling language, the book's presentation makes it easy to absorb the content and integrate it as you learn the physiology of other bodily systems. Written to help you understand essential concepts rather than merely memorize facts, this unique text examines many medically relevant facets of this important body system, including anatomy, pathophysiology, and therapeutics, in concert with physiological information.
- 2007Johnson, Leonard R.
- 2015 SpringerMaithel, Shishir Kumar; Merchant, Nipun B.; Pawlik, Timothy M.Tracheo-esophageal Fistula -- Esophageal strictures refractory to endoscopic dilatation -- Esophgeal anastomotic leak -- Transhiatal esophagectomy: intraoperative disasters -- Chyle leak after esophageal surgery -- Management of airway, hoarseness and vocal cord dysfunction after esophagectomy -- Severe reflux induced esophagitis -- Introperative solutions for gastric conduit that will not reach -- Injury to the right gastroepiploic artery -- Intraoperative solutions for ischemic gastric conduit -- Jejunal feeding tube complications -- Bile reflux and gastroparesis -- Gastric surgery: dealing with dumping syndrome -- Afferent loop syndrome -- Duodenal stump blowout -- Postoperative complications after surgery for gastric cancer: Anastomotic leakage -- Hepatobiliary and pancreatic surgery: postoperative hepatic insufficiency -- Biliary leaks and thoracobiliary fistula -- Contralateral bile duct injury during hepatic resection -- Massive Intra-operative Hemorrhage During Hepato-Biliary and Pancreatic Surgery -- Hepatobiliary and Pancreatic Surgery: Intraoperative injury to Hepatic Arterial Structures -- Hepatobiliary and pancreatic surgery: hepatic abscess -- Hepaticojejunostomy anastomotic strictures -- Stricture at Pancreatico-Jejunostomy or Pancreatico-Gastrostomy -- Postoperative Portal, Mesenteric and Splenic Vein Thrombosis -- Post-pancreatectomy Hemorrhage: Early and Late -- Major Disruptions of Pancreaticojejunostomy -- Persistent Pancreatic Fistula -- Management of Chyle Leaks Following Pancreatic Resection -- Hepatobiliary and Pancreatic Surgery: Preventing Pancreatic Fistula following Distal Pancreatectomy -- Pearls for the Small Bowel and Colon That Will Not Reach -- Anastomotic Leak / Pelvic Abscess -- Management of Anastomotic Stricture -- Colorectal Surgery: Intraoperative Ureteral Injury -- Colorectal surgery: Prostatic Urethral Injury -- Vaginal Injury During Stapled -- Anastomosis -- Management of rectovaginal fistula -- Management of Presacral / Pelvic Bleeding -- Breakdown / Nonhealing of Perineal Wound -- Complications after TEM (Transanal Endoscopic Microsurgery) and TAMIS Maria -- Parastomal hernia -- Stoma Retraction/Ischemia/Stenosis -- Incontinence after Lateral Internal Sphincterotomy/ Fistulotomy -- Anal Stenosis after Hemorrhoidectomy: Avoidance and Management -- Delivering Bad News: Conversations with My Surgeon.
- 2008 SpringerBaud, C.; Couture, Alain.
- 2012 SpringerMcCallum, Richard W.; Parkman, Henry P.
- 2012Xu, Xiao; Brunet, Anne; Chua, Katrin Faye; Kim, Stuart K.; Snyder, Michael.Stress is a fundamental aspect of aging as accumulated damage from a lifetime of stress can limit lifespan, and protective responses to stress can extend lifespan. In this study, we identify a conserved C. elegans GATA transcription factor, egl-27, that is involved in several stress responses and aging. We found that overexpression of egl-27 extends the lifespan of wild-type animals. Furthermore, egl-27 is required for the pro-longevity effects from impaired insulin/IGF-1 like signaling (IIS), as reduced egl-27 activity fully suppresses the longevity of worms that are mutant for the IIS receptor, daf-2. egl-27 expression is inhibited by daf-2 and activated by pro-longevity factors daf-16/FOXO and elt-3/GATA, suggesting that egl-27 acts at the intersection of IIS and GATA pathways to extend lifespan. Consistent with its role in IIS signaling, we found that egl-27 is involved in stress response pathways. egl-27 expression is induced in the presence of multiple stresses, its targets are significantly enriched for many types of stress genes, and altering levels of egl-27 itself affects survival to heat and oxidative stress. Finally, we found that egl-27 expression increases between young and old animals, suggesting that increased levels of egl-27 in aged animals may act to promote stress resistance. These results identify egl-27 as a novel factor that links stress and aging pathways.
- 2006 CRCnetBASEFuterman, Anthony H.; Zimran, Ari.Chapter 1. Introduction: Overview and Historical Perspective / Roscoe O. Brady -- Chapter 2. Gaucher Disease: Molecular Biology and Genotype-Phenotype Correlations / Kathleen S. Hruska, Mary E. LaMarca, and Ellen Sidransky -- Chapter 3. Cell Biology and Biochemistry of Acid β-Glucosidase: The Gaucher Disease Enzyme / Gregory A. Grabowski, Andrzej Kazimierczuk, and Benjamin Liou -- Chapter 4. Saposin C and Other Sphingolipid Activator Proteins / Silvia Locatelli Hoops, Thomas Kolter, and Konrad Sandhoff -- Chapter 5. The X-Ray Structure of Human Acid-β-Glucosidase: Implications for Second-Generation Enzyme Replacement Therapy / Lakshmanane Premkumar, Israel Silman, Joel L. Sussman, and Anthony H. Futerman -- Chapter 6. Cellular Pathology in Gaucher Disease / Anthony H. Futerman -- Chapter 7. The Biochemistry and Cellular Biology of Sphingolipids and Glucosylceramide / James A. Shayman -- Chapter 8. The Development of Enzyme Replacement Therapy for Lysosomal Diseases: Gaucher Disease and Beyond / Edward H. Schuchman and Silvia Muro -- Chapter 9. Gaucher Disease Animal Models / Ying Sun, You-Hai Xu, and Gregory A. Grabowski -- Chapter 10. Type 1 Gaucher Disease - Clinical Features / Pramod K. Mistry and Ari Zimran -- Chapter 11. Neuronopathic Gaucher Disease / Raphael Sc hiffmann and Ashok Vellodi -- Chapter 12. Pathologic Anatomy of Gaucher Disease: A Pictorial Essay / Robert E. Lee -- Chapter 13. Neuropathological Aspects of Gaucher Disease / Kondi Wong -- Chapter 14. Diagnosis and Laboratory Features / Carla E.M. Hollak and Johannes M.F.G. Aerts -- Chapter 15. Imaging in Gaucher Disease, Focusing on Bone Pathology / Mario Maas and Erik M. Akkerman -- Chapter 16. Radionuclide Evaluation of Gaucher Disease / Giuliano Mariani and Paola A. Erba -- Chapter 17. Epidemiology and Screening Policy / Peter J. Meikle, Maria Fuller, and John J. Hopwood Chapter 18. Enzyme Replacement Therapy for Type I Gaucher Disease / Ari Zimran, Bruno Bembi, and Gregory M. Pastores -- Chapter 19. Substrate Reduction Therapy / Frances M. Platt and Timothy M. Cox -- Chapter 20. Pharmacologic Chaperone Therapy for Lysosomal Diseases / Robert J. Desnick and Jian-Qiang Fan -- Chapter 21. The Significance of the Blood-Brain Barrier for Gaucher Disease and Other Lysosomal Storage Diseases / David J. Begley -- Chapter 22. Hematopoietic Stem Cell Transplantation, Stem Cells, and Gene Therapy / Charles Peters and William Krivit -- Chapter 23. Ethical Concerns in Treating Rare Diseases with Expensive Therapy / Deborah Elstein and Avraham Steinberg -- Chapter 24. Societal Aspects in Treating Rare Diseases with Expensive Therapy / Deborah Elstein and Avi Israeli -- Chapter 25. Gaucher Disease as a Model for an Orphan Disease: Medical Aspects / Jill Waalen and Ernest Beutler -- Chapter 26. Meeting the Needs of Patients with Gaucher Disease: Pioneering a Sustainable Model for Ultra-Orphan Diseases / David P. Meeker and Henri A. Termeer -- Chapter 27. Patients’ Perspective / Susan Lewis, Tanya Collin-Histed, Jeremy Manuel, and Greg Macres -- Chapter 28. Societal Perspective: Comment / Abby Alpert, Alan M. Garber, and Dana P. Goldman -- Chapter 29. Gaucher Associations Around the World.
- 2005 CRCnetBASERue, Hvard; Held, Leonhard.
- 2011 CRCnetBASEShi, Jian Qing; Choi, Taeryon."Gaussian Process Regression Analysis for Functional Data presents nonparametric statistical methods for functional regression analysis, specifically the methods based on a Gaussian process prior in a functional space. The authors focus on problems involving functional response variables and mixed covariates of functional and scalar variables. Covering the basics of Gaussian process regression, the first several chapters discuss functional data analysis, theoretical aspects based on the asymptotic properties of Gaussian process regression models, and new methodological developments for high dimensional data and variable selection. The remainder of the text explores advanced topics of functional regression analysis, including novel nonparametric statistical methods for curve prediction, curve clustering, functional ANOVA, and functional regression analysis of batch data, repeated curves, and non-Gaussian data. Many flexible models based on Gaussian processes provide efficient ways of model learning, interpreting model structure, and carrying out inference, particularly when dealing with large dimensional functional data. This book shows how to use these Gaussian process regression models in the analysis of functional data. Some MATLAB® and C codes are available on the first author's website"--Publisher's website.
- 2011 Springer ProtocolsGevaert, Kris; Vandekerckhove, Joël.Mass spectrometry-driven proteomics : an introduction / Kenny Helsens [and others] -- Metabolic labeling of model organisms using heavy nitrogen (15N) / Joost W. Gouw, Bastiaan B.J. Tops, and Jeroen Krijgsveld -- Trypsin-catalyzed oxygen-18 labeling for quantitative proteomics / Wei-Jun Qian [and others] -- ICPL labeling strategies for proteome research / Friedrich Lottspeich and Josef Kellermann -- Quantitative proteome analysis using isobaric peptide termini labeling (IPTL) / Magnus Ø. Arntzen [and others] -- Complete chemical modification of amine and acid functional groups of peptides and small proteins / Casey J. Krusemark [and others] -- Production and use of stable isotope-labeled proteins for absolute quantitative proteomics / Dorothée Lebert [and others] -- Organelle proteomics / Sophie Duclos and Michel Desjardins -- Membrane protein digestion -- comparison of LPI HexaLane with traditional techniques / Ping Sui [and others] -- GeLCMS for in-depth protein characterization and advanced analysis of proteomes / Alicia Lundby and Jesper V. Olsen -- Exploring new proteome space : combining Lys-N proteolytic digestion and strong cation exchange (SCX) separation in peptide-centric MS-driven proteomics / Nadia Taouatas, Shabaz Mohammed, and Albert J.R. Heck -- Quantitation of newly synthesized proteins by pulse labeling with azidohomoalanine / Gertjan Kramer [and others] -- Analytical strategies in mass spectrometry-based phosphoproteomics / Heidi Rosenqvist, Juanying Ye, and Ole N. Jensen -- Protocol on the use of titanium dioxide chromatography for phosphoproteomics / Martijn W.H. Pinkse, Simone Lemeer, and Albert J.R. Heck -- Positional proteomics at the N-Terminus as a means of proteome simplification / Gemma R. Davidson, Stuart D. Armstrong, and Robert J. Beynon -- N-Terminomics : a high-content screen for protease substrates and their cleavage sites / John C. Timmer and Guy S. Salvesen -- Protease specificity profiling by tandem mass spectrometry using proteome-derived peptide libraries / Oliver Schilling, Ulrich auf dem Keller, and Christopher M. Overall -- Identification of proteolytic products and natural protein N-Termini by terminal amine isotopic labeling of substrates (TAILS) / Alain Doucet [and others] -- Lectins as tools to select for glycosylated proteins / Els J.M. Van Damme -- Strong cation exchange chromatography for analysis of sialylated glycopeptides / Katharina Lohrig, Albert Sickmann, and Urs Lewandrowski -- Titanium dioxide enrichment of sialic acid-containing glycopeptides / Giuseppe Palmisano, Sara E. Lendal, and Martin R. Larsen -- Chemical De-O-glycosylation of glycoproteins for applications in LC-based proteomics / Franz-Georg Hanisch -- Ubiquitination and degradation of proteins / Yelena Kravtsova-Ivantsiv and Aaron Ciechanover -- Bioinformatics challenges in mass spectrometry-driven proteomics / Lennart Martens -- Case study on the comparison of different software tools for automated quantification of peptides / Niklaas Colaert [and others].
- Ó hÓgartaigh, Margaret; Preston, Margaret H."I was right glad to be rid of it" : dental medical practice in eighteenth-century Ireland / James Kelly -- Women and tuberculosis in Ireland / Greta Jones -- Infant and child mortality in Dublin a century ago / Cormac Ó Gráda -- Cure or custody : therapeutic philosophy at the Connaught District Lunatic Asylum / Oonagh Walsh -- Gender and criminal lunacy in nineteenth-century Ireland / Pauline Prior -- Between habitual drunkards and alcoholics : inebriate women and reformatories in Ireland, 1899-1919 / Elizabeth Malcolm -- Managing midwifery in Dublin : practice and practitioners, 1700-1800 / Philomena Gorey -- Lady Dudley's district nursing scheme and the Congested Districts Board, 1903-1923 / Ciara Breathnach -- "The wages of sin is death" : Lock hospitals, venereal disease, and gender in prefamine Ireland / Laurence M. Geary -- "Sickness," gender, and national health insurance in Ireland, 1920s to 1940s / Mel Cousins -- "A perpetual nightmare" : women, fertility control, the Irish state, and the 1935 ban on contraceptives / Sandra McAvoy -- "A probable source of infection" : the limitations of venereal disease policy, 1943-1951 / Susannah Riordan -- Prophylactics and prejudice : venereal diseases in Northern Ireland during the Second World War / Leanne McCormick.
- 2009 SpringerKendel, Friederike.
- 2009 SpringerTucker, Joseph D.China's concentrated HIV epidemic is on the brink of becoming a generalized one and syphilis infection has become a major public health threat. Social factors relating to gender and gender inequality exacerbate the spread of HIV and sexually transmitted infections (STI) in China. A better understanding of the proximate social determinants of HIV related to gender will be crucial to effectively curbing HIV and other STIs in China. Aspects of China's governance - including administrative procedures, the developing legal system, social institutions, and the public health infrastructure are instrumental in shaping strategies and responses to HIV. International studies suggest that women who are more economically and socially vulnerable may also have a greater risk of HIV infection, yet few initiatives have focused on discrete areas where achievable and sustainable gender policy measures could be linked to the public health response. This study presents perspectives ranging from criminology to social psychology to better understand how gender perspectives can inform HIV policy in the context of China. - Publisher's Description.
- 2010 WHOOlukoya, Peju; Ravindran, Sudari.Also available: Print – 2010
- 2010 WHOSamet, Jonathan M.; Yoon, Soon-Young."This publication contributes to the scientific understanding of gender, women, and tobacco in the context of efforts to control the global tobacco epidemic. Topics covered include determinants of starting to use tobacco; exposure to second-hand smoke; the impact that tobacco use has on health; addiction and cessation; treatment programs; and gender and human rights policy. The publication also addresses national economic policy with regard to tobacco control, international treaties, and strategies for tobacco-free mobilization at the regional and international levels. Special attention is paid to an analysis of policies that affect girls and women throughout the life course. Men's responsibility to protect women against second-hand smoke is also highlighted"--Publisher's description.Also available: Print – 2010
- 2009 CRCnetBASETempleton, Nancy Smyth.Also available: Print – 2009
- 2015 SpringerRakoczy, P. Elizabeth.In this book, leading experts provide detailed descriptions of the exciting treatments that are expected to become part of the ophthalmologist?s arsenal within the next 10?20 years. The treatments discussed relate to a wide variety of conditions, including macular degeneration, Leber?s congenital amaurosis, retinitis pigmentosa and choroideremia. The authors explain clearly how different gene and cell therapies work and provide first-hand accounts of the difficulties that they have faced in bringing these technologies to clinical trial, such as issues relating to funding and ownership. Results achieved to date are presented, and the further steps required before the treatment in question can become a routine option are considered. Gene- and Cell-Based Treatment Strategies for the Eye is unique in showing the organic development of cutting-edge science into potential treatments for eye disease without compromising on accurate reporting of scientific facts. It will persuade the average practitioner or researcher ? whether ophthalmologist, health worker, or scientist ? that change is indeed coming and is not just a hollow promise of the tabloid media.
- 2007. KargerVolff, Jean-Nicolas.Coevolution within and between genes / Galtier, N.; Dutheil, J. -- Evolution of protein-protein interaction network / Makino, T.; Gojobori, T. -- Bacterial flagella and type III secretion: case studies in the evolution of complexity / Pallen, M.J.; Gophna, U. -- Comparative genomics and evolutionary trajectories of viral ATP dependent DNA-packaging systems / Burroughs, A.M.; Iyer, L.M.; Aravind, L. -- General trends in the evolution of prokaryotic transcriptional regulatory networks / Madan Babu, M.; Balaji, S.; Aravind, L. -- Divergence of regulatory sequences in duplicated fish genes / Van Hellemont, R. ... [et al.] -- Evolution of gene function on the X chromosome versus the autosomes / Singh, N.D.; Petrov, D.A. -- Amino acid repeats and the structure and evolution of proteins / Albà, M.M.; Tompa, P.; Veitia, R.A. -- Origination of chimeric genes through DNA-level recombination / Arguello, J.R. ... [et al.] -- Exaptation of protein coding sequences from transposable elements / Bowen, N.J.; Jordan, I.K. -- Modulation of host genes by mammalian transposable elements / Makalowski, W.; Toda, Y. -- Modern genomes with retro-look: retrotransposed elements, retroposition and the origin of new genes / Volff, J.-N.; Brosius, J.
- 2011 CRCnetBASEWu, William; Kaufman, Peter B.; Welsh, Michael J.; Zhang, Helen H."The third edition of this popular reference covers a variety of techniques related to gene manipulation, including DNA isolation, preparation, screening, and analysis. Topics range from very basic methods to current and sophisticated technologies, including methodologies created and tested by the authors. Other topics include approaches to grant funding and SiRNA technology. The authors offer detailed, step-by-step explanations of protocols and helpful troubleshooting guides. This edition features new techniques for every chapter, as well as several new chapters"--Provided by publisher.
- 2015 Springer ProtocolsBo, Xuenong; Verhaagen, Joost.Adeno-Associated Viral Vectors for Gene Delivery to the Nervous System -- Lentiviral Vectors for Gene Delivery to the Nervous System -- Gene Therapy for Parkinson's Disease: AAV-5-Mediated Delivery of Glial Cell Line-Derived Neurotrophic Factor (GDNF) -- Gene Delivery and Gene Therapy for Alzheimer's Disease -- Gene Therapy for Huntington's Disease -- Gene Therapy Approaches to Promoting Axonal Regeneration After Spinal Cord Injury -- Gene Delivery to Neurons of the Dorsal Root Ganglia Using Adeno-Associated Viral Vectors -- Targeted Gene Therapy for Ischemic Stroke -- Adeno-Associated Viral Gene Therapy for Retinal Disorders -- Gene Therapy for Epilepsies -- AAV Gene Therapy Strategies for Lysosomal Storage Disorders with Central Nervous System Involvement -- Gene Therapy in Spinal Muscular Atrophy (SMA) Models Using Intracerebroventricular Injection into Neonatal Mice -- Gene Therapy for Chronic Pain: How to Manipulate and Unravel Pain Control Circuits from the Brain? -- Gene Therapy Approaches Using Reproducible and Fully Penetrant Lentivirus-Mediated Endogenous Glioma Models
- 2015 Springer ProtocolsLu, Long Jason.Microarray Transposon Tracking for the Mapping of Conditionally Essential Genes in Campylobacter jejuni -- Identifying Essential Streptococcus sanguinis Genes Using Genome-Wide Deletion Mutation -- Defining Essential Genes and Identifying Virulence Factors of Porphyromonas gingivalis by Massively-Parallel Sequencing of Transposon Libraries (Tn-seq) -- Identification of Essential Genes and Synthetic Lethal Gene Combinations in Escherichia coli K-12 -- Identification of Genes Essential for Leptospirosis -- Identifying Essential Genes in Mycobacterium tuberculosis by Global Phenotypic Profiling -- Essential Genes in the Infection Model of Pseudomonas aeruginosa-PCR-Based Signature-Tagged Mutagenesis -- Genome-Wide Synthetic Genetic Screening by Transposon Mutagenesis in Candida albicans -- An Integrated Machine-Learning Model to Predict Prokaryotic Essential Genes -- A Statistical Framework for Improving Genomic Annotations of Transposon Mutagenesis (TM) Assigned Essential Genes -- A Proposed Essential Gene Discovery Pipeline: A Campylobacter jejuni Case Study -- Computational Prediction of Essential Metabolic Genes Using Constraint-Based Approaches -- Three Computational Tools for Predicting Bacterial Essential Genes -- Gene Essentiality Analysis Based on DEG 10, an Updated Database of Essential Genes -- Discovering Essential Domains in Essential Genes.
- 2010 SpringerWallace, Rodrick; Wallace, Deborah.
- 2006 SpringerMa, Jun.
- 2012Bua, Dennis Jacob; Gozani, Or; Morrison, Ashby J.; Nelson, W. J.The physiological state of the genome is chromatin. Chromatin is a dynamic polymer composed of genomic DNA, histone proteins, and other factors. Dysregulation of chromatin homeostasis can lead to diverse human pathologies including cancer. This work focuses on chromatin-based mechanisms of gene regulation; more specifically the (1) targeting and (2) stabilization of gene-regulatory proteins on the chromatin template. In regard to chromatin targeting, not much is known about how gene-regulatory proteins selectively associate with their targets. Herein we detail the discovery of a new targeting factor, the nuclear phospholipid phosphatidylinositol-5-phosphate (PtdIns(5)P). PtdIns(5)P directly interacts with the tumor suppressor ING2 (inhibitor of growth family member 2) in the nucleus to coordinate gene expression of select ING2 targets. In regard to chromatin stabilization, lysine methylation is a principle mechanism for retaining chromatin-effector modules at discrete chromatin zones. Numerous lysine methylation events have been discovered on the major protein component of chromatin, histones, but relatively few specific modules have been characterized to sense these modifications. We screened through a library of putative methyl-lysine binding domains, which resulted in the identification of three novel chromatin binding modules. Taken together these data shed insight into the molecular modes of action of gene regulation by chromatin and phosphoinositide pathways.
- 1980-Lewin, Benjamin.--v. 2. Eucaryotic chromosomes.
- 2007/2008Jordan, ChaRandle.
- 2011 Springer ProtocolsO'Driscoll, Lorraine.Real-time PCR and multiplex approaches / Olga L. Gurvich and Mikhail Skoblov -- Reverse-transcriptase polymerase chain reaction to detect extracellular mRNAs / Sweta Rani and Lorraine O'Driscoll -- Microarray analysis of mRNAs : experimental design and data analysis fundamentals / Jai Prakash Mehta -- Software and tools for microarray data analysis / Jai Prakash Mehta and Sweta Rani -- Analysis of gene expression as relevant to cancer cells and circulating tumour cells / Anne M. Friel, John Crown, and Lorraine O'Driscoll -- Gene expression profiling in formalin-fixed, paraffin-embedded tissues using the whole-genome DASL assay / Craig S. April and Jian-Bing Fan -- MicroRNA expression analysis : techniques suitable for studies of intercellular and extracellular MicroRNAs / Erica Hennessy and Lorraine O'Driscoll -- Western blotting analysis as a tool to study receptor tyrosine kinases / Serena Germano and Lorraine O'Driscoll -- 2D gel electrophoresis and mass spectrometry identification and analysis of proteins / Paula Meleady -- Design, construction, and analysis of cell line arrays and tissue microarrays for gene expression analysis / Kathy Gately, Keith Kerr, and Ken O'Byrne -- Immunohistochemical and immunofluorescence procedures for protein analysis / Kishore Reddy Katikireddy and Finbarr O'Sullivan -- Advanced microscopy : laser scanning confocal microscopy / Orla Hanrahan, James Harris, and Chris Egan -- Isolation of exosomes for subsequent mRNA, microRNA, and protein profiling / Sweta Rani [and others] -- Atomic force microscopy and high-content analysis : two innovative technologies for dissecting the relationship between epithelial-mesenchymal transition-related morphological and structural alterations and cell mechanical properties / Stephen T. Buckley, Anthony M. Davies, and Carsten Ehrhardt.
- 2009 CRCnetBASEGöhlmann, Hinrich; Talloen, Willem."Gene expression studies merge three disciplines with different historical backgrounds: molecular biology, bioinformatics, and biostatistics. This book tears down the omnipresent language barriers among researchers of these different backgrounds by explaining the entire process of a gene expression study from conception to interpretation. It covers important technical and statistical pitfalls and problems, helping not only to explain concepts outside the domain of researchers, but to provide additional guidance in their field of expertise. The book also describes technical and statistical methods conceptually with illustrative examples, enabling those inexperienced with gene expression studies to grasp the basic principles"--Provided by publisher.
- Goeddel, David V.Also available: Print – 1990
- 2011 ScienceDirectAtkinson, Janette; Braddick, O. J.; Innocenti, Giorgio M.How does the genome, interacting with the multi-faceted environment, translate into the development by which the human brain achieves its astonishing, adaptive array of cognitive and behavioural capacities? Why and how does this process sometimes lead to neurodevelopmental disorders with a major, lifelong personal and social impact? This volume of Progress in Brain Research links findings on the structural development of the human brain, the expression of genes in behavioural and cognitive phenotypes, environmental effects on brain development, and developmental processes in perception, action.
- 2007 Springer ProtocolsOchs, Michael F.Gene function inference from gene expression of deletion mutants / Ghislain Bidaut -- Association analysis for large-scale gene set data / Stefan A. Kirov, Bing Zhang, and Jay R. Snoddy -- Estimating gene function with least squares nonnegative matrix factorization / Guoli Wang and Michael F. Ochs -- From promoter analysis to transcriptional regulatory network prediction using PAINT / Gregory E. Gonye ... [et al.] -- Prediction of intrinsic disorder and its use in functional proteomics / Vladimir N. Uversky ... [et al.] -- Sybil : methods and software for multiple genome comparison and visualization / Jonathan Crabtree ... [et al.] -- Estimating protein function using protein-protein relationships / Shailesh V. Date -- Bioinformatics tools for modeling transcription factor target genes and epigenetic changes / Ramana V. Dvuluri -- Mining biomedical data using MetaMap Transfer (MMTx) and the Unified Medical Language System (UMLS) / John D. Osborne ... [et al.] -- Statistical methods for identifying differentially expressed gene combinations / Yen-Yi Ho ... [et al.] -- Gene function analysis using the chicken B-cell line DT40 / Randolph B. Caldwell ... [et al.] -- Design and application of a shRNA-based gene replacement retrovirus / Rugang Zhang, Peter D. Adams, and Xiaofen Ye -- Construction of simple and efficient DNA vector-based short hairpin RNA expression systems for specific gene silencing in mammalian cells / Tsung-Lin Cheng and Wen-Tsan Chang -- Selection of recombinant antibodies from antibody gene libraries / Michael Hust, Stefan Dübel, and Thomas Schirrmann -- A bacterial/yeast merged two-hybrid system : protocol for yeast screening with single of parallel baits / Nadezhda Y. Tikhmyanova ... [et al.] -- A bacterial/yeast merged two-hybrid system : protocol for bacterial screening / Ilya G. Serebriiskii, Nadia Milech, and Erica A. Golemis -- Engineering Cys2His2 zinc finger domains using a bacterial cell-based two-hybrid selection system / Stacey Thibodeau-Beganny and J. Keith Joung.
- 2009 Springer ProtocolsKühn, Ralf; Wurst, Wolfgang.Overview on mouse mutagenesis / Ralf Kühn and Wolfgang Wurst -- Construction of gene-targeting vectors by recombineering / Song-Choon Lee, Wei Wang, and Pentao Liu -- Gene-trap vectors and mutagenesis / Silke De-Zolt ... [et al.] -- Chromosome engineering in ES cells / Louise vander Weyden, Charles Shaw-Smith, and Allan Bradley -- Gene modification in embryonic stem cells by single-stranded DNA oligonucleotides / Marieke Aarts ... [et al.] -- Generation of shRNA transgenic mice / Christiane Hitz ... [et al.] -- Mutagenesis of mouse embryonic stem cells with ethylmethanesulfonate / Robert Munroe and John Schimenti -- Gene targeting in mouse embryonic stem cells / Lino Tessarollo ... [et al.] -- Manipulating mouse embryonic stem cells / Eileen Southon and Lino Tessarollo -- ES cell line establishment / Heidrun Kern and Branko Zevnik -- Generation of double-knockout embryonic stem cells / Eva Wielders, Marleen Dekker, and Hein te Riele -- Differentiation analysis of pluripotent mouse embryonic stem (ES) cells in vitro / Insa S. Schroeder ... [et al.] -- Cloning of ES cells and mice by nuclear transfer / Sayaka Wakayama, Satoshi Kishigami, and Teruhiko Wakayama -- Isolation, microinjection, and transfer of mouse blastocysts / Susan W. Reid and Lino Tessarollo -- Aggregation chimeras : combining ES cells, diploid, and tetraploid embryos / Mika Tanaka ... [et al.] -- VelociMouse : fully ES cell-derived F0-generation mice obtained from the injection of ES cells into eight-cell-stage embryos / Thomas M. DeChiara ... [et al.] -- Generation of Cre recombinase-expressing transgenic mice using bacterial artificial chromosomes / Jan Rodriguez Parkitna, David Engblom, and Günther Schütz -- Inducible Cre mice / Susanne Feil, Nadejda Valtcheva, and Robert Feil -- Creation and use of a Cre recombinase transgenic database / Andras Nagy, Lynn Mar, and Graham Watts -- Transposon mutagenesis in mice / David A. Largaespada -- Lentiviral transgenesis / Alexander Pfeifer and Andreas Hofmann -- Sperm cryopreservation and in vitro fertilization / Susan Marschall, Auke Boersma, and Martin Hrabé de Angelis -- Influence of genetic background on genetically engineered mouse phenotypes / Thomas Doetschman -- Pathologic phenotyping of mutant mice / Roderick T. Bronson -- Systemic first-line phenotyping / Valérie Gailus-Durner ... [et al.]
- 2006 Springer ProtocolsBina, Minou.Analysis of allele-specific gene expression / Julian C. Knight -- Construction of microRNA-containing vectors for expression in mammalian cells / Yoko Fukuda, Hiroaki Kawasaki, and Kazunari Taira -- Mining microarray data at NCBI's gene expression omnibus (GEO) / Tanya Barrett and Ron Edgar -- The Stanford microarray database: a user's guide / Jeremy Gollub, Catherine A. Ball, and Gavin Sherlock -- Detecting nucleosome ladders on unique DNA sequences in mouse liver nuclei / Tomara J. Fleury, Alfred Cioffi, and Arnold Stein -- DNA methyltransferase probing of DNA-protein interactions / Scott A. Hoose and Michael P. Kladde -- Protein binding microarrays (PBMS) for rapid, high-throughput characterization of the sequence specificities of DNA binding proteins / Michael F. Berger and Martha L. Bulyk -- Quantitative profiling of protein-DNA binding on microarrays / Jiannis Ragoussis, Simon Field, and Irina A. Udalova -- Analysis of protein-DNA binding by streptavidin-agarose pulldown / Kenneth K. Wu -- Isolation and mass spectrometry of specific DNA binding proteins / Mariana Yaneva and Paul Tempst -- Isolation of transcription factor complexes by in vivo biotinylation tagging and direct binding to streptavidin beads / Patrick Rodriguez ... [et al.]. Use of genome browsers to locate your favorite genes / Minou Bina -- Methods for identifying and mapping recent segmental and gene duplications in eukaryotic genomes / Razi Khaja ... [et al.] -- Identification and mapping of paralogous genes on a known genomic DNA sequence / Minou Bina -- Quantitative DNA fiber mapping in genome research and construction of physical maps / Heinz-Ulrich G. Weier and Lisa W. Chu -- PRINS for mapping single copy genes / Avirachan T. Tharapel and Stephen S. Wachtel -- VISTA family of computational tools for comparative analysis of DNA sequences and whole genomes / Inna Dubchak and Dmitriy V. Ryaboy -- Computational prediction of cis-Regulatory modules from multispecies alignments using galaxy, table browser, and GALA / Laura Elnitski, David King, and Ross C. Hardison -- Comparative promoter analysis in vertebrate genomes with the CORG workbench / Christoph Dieterich and Martin Vingron -- cis-Regulatory region analysis using BEARR / Vinsensius Berlian Vega -- A database of 9-Mers from promoter region of human protein-coding genes / Minou Bina, Phillip Wyss, and Syed Rehan Shah -- A program toolkit for the analysis of regulatory regions of genes / Phillip Wyss, Sheryl A. Lazarus, and Minou Bina --
- Aquino de Muro, Marilena; Rapley, Ralph.
- 2008 CRCnetBASELidbury, Brett A.; Mahalingam, Suresh.A perspective on the future clinical impact of genetic diagnosis and gene-based drug therapies for patient health / Julian W. Tang -- Virally-encoded microRNA (miRNA): candidates for gene silencing / Ralph A. Tripp ... [et al.] -- Development of gene profile-responsive antisense agents / Sergei A. Kazakov and Brian H. Johnston -- Gene profiles in drug development: applications in target identification, biomarker discovery, and compound characterization / Eric A.G. Blomme and Dimitri Semizarov -- Gene profiles and cancer / Beverly A. Teicher -- RNA viruses and RNA-based drugs: a perfect match for RNA delivery and the identification of candidate therapeutic target inflammatory molecules / Brett A. Lidbury ... [et al.] -- Ethical considerations for a genetic future in diagnosis and drug development / Lexie Brans and Brett A. Lidbury.
- 2013 Springer ProtocolsBina, Minou.1. Gene regulation / Minou Bina -- 2. Isolation of nuclei for use in genome-wide DNase hypersensitivity assays to probe chromatin structure / Guoyu Ling and David J. Waxman -- 3. DNase I digestion of isolated nuclei for genome-wide mapping of Denise hypersensitivity sites in chromatin / Guoyu Ling and David J. Waxman -- 4. Isolation and analysis of DNA derived from nucleosome-free regions / Matthew Murtha, Yatong Wang, Claudio Basilico, and Lisa Dailey -- 5. Acquisition of high quality DNA for massive parallel sequencing by in vivo chromatin immunoprecipitation / M. van den Boogaard, L.Y.E. Wong, V.M. Christoffels and P. Barnett -- 6. Luciferase assay to study the activity of a cloned promoter DNA fragment / Nina Solberg and Stefan Krauss -- 7. Promoter deletion analysis using a dual-luciferase reporter system / Yong Zhong Xu, Cynthia Kanagaratham, Sylwia Jancik and Danuta Radzioch -- 8. Application of mRNA display for in vitro selection of DNA-binding transcription factor complexes / Seiji Tateyama and Hiroshi Yanagawa -- 9. Isolation of intracellular protein -- DNA complexes using HaloCHIP an antibody-free alternative to chromatin immunoprecipitation / Danette L. Daniels and Marjeta Urh -- 10. Modified yeast one-hybrid system for genome-wide identification of transcription factor binding sites / Kazuyuki Yanai -- 11. Identifying specific protein-DNA interactions using SILAC-based quantitative proteomics / Cornelia G. Spruijt, H. Irem Baymaz, and Michiel Vermeulen -- 12. Electrophoretic mobility-shift and super-shift assays for studies and characterization of protein-DNA complexes / Elsie I. Pares-Matos -- 13. Combination of native and denaturing PAGE for the detection of protein binding regions in long fragments of genomic DNA / Kristel Kaer and Mart Speek -- 14. Quantitative nanoproteomics approach for protein complex (QNanoPX) using gold nanoparticle-based DNA probe / Shu-Hui Chen and Mei-Yin Lin -- 15. Chromatin assembly and in vitro transcription analyses for evaluation of individual protein activities in multicomponent transcriptional complexes / Takayuki Furumatsu and Hiroshi Asahara -- 16. Using FRET to monitor protein-induced DNA bending : the TBP-TATA complex as a model system / Rebecca H. Blair, James A. Goodrich, and Jennifer F. Kugel -- 17. Promoter independent abortive transcription assays unravel functional interactions between TFIIB and RNA polymerase / Simone C. Wiesler, Finn Werner, and Robert O.J. Weinzierl -- 18. Fluorescence cross-correlation spectroscopy (FCCS) to observe dimerization of transcription factors in living cells / Hisayo Sadamoto and Hideki Muto -- 19. Nuclear recruitment assay as a tool to validate transcription factor interactions in mammalian cells / C.J.J. Boogerd, V.M. Christoffels, and P. Barnett -- 20. Preparation of cell lines for single-cell analysis of transcriptional activation dynamics / Ilona U. Rafalska-Metcalf and Susan M. Janicki -- 21. Peptide microarrays for profiling of serine/threonine kinase activity of recombinant kinases and lysates of cells and tissue samples / Riet Hilhorst, Liesbeth Houkes, Monique Mommersteeg, Joyce Musch, Adriënne van den Berg and Rob Ruijtenbeck -- 22. Immunoaffinity purification of protein complexes from mammalian cells / Chieri Tomomori-Sato, Shigeo Sato, Ronald C. Conaway and Joan W. Conaway -- 23. Simple and efficient identification of chromatin modifying complexes and characterization of complex composition / Jeong-Heon Lee and David Skalnik -- 24. Heavy methyl-SILAC labeling coupled with liquid chromatography and high-resolution mass spectrometry to study the dynamics of site-specific histone methylation / Xing-Jun Cao, Barry M. Zee, and Benjamin A. Garcia -- 25. Analysis of p300 occupancy at the early stage of stem cell differentiation by chromatin immunoprecipitation / Melanie Le May and Qiao Li -- 26. Mammalian two-hybrid assays for studies of interaction of p300 with transcription factors / Daniela B. Mendonnc̦a, Gustavo Mendonc̦a, and Lyndon F. Cooper -- 27. Fluorescence anisotropy microplate assay to investigate the interaction of full-length steroid receptor coactivator-1a with steroid receptors / Chen Zhang, Steven K. Nordeen, and David J. Shapiro -- 28. Use of histone deacetylase inhibitors to examine the roles of bromodomain and histone acetylation in p300-dependent gene expression / Jihong Chen and Qiao Li -- 29. Histone deacetylase inhibitor valproic acid as a small molecule inducer to direct the differentiation of pluripotent stem cells / Jihong Chen, Natascha Lacroix, and Qiao Li -- 30. Sedimentation and immunoprecipitation assays for analyzing complexes that repress transcription / Ping Lu, Bruce S. Hostager, Paul B. Rothman, and John D. Colgan -- 31. Methods for studies of protein interactions with different DNA methyltransferases / Jianchang Yang.
- 2012 Springer ProtocolsDeplancke, Bart; Gheldof, Nele.pt. I. Regulatory state components. 1. How do you find transcription factors? Computational approaches to compile and annotate repertoires of regulators for any genome / Juan M. Vaquerizas, Sarah A. Teichmann, and Nicholas M. Luscombe. 2. Expression pattern analysis of regulatory transcription factors in Caenorhabditis elegans / Huiyun Feng, Hannah L. Craig, and Ian A. Hope. 3. High-throughput SELEX determination of DNA sequences bound by transcription factors in vitro / Nobuo Ogawa and Mark D. Biggin. 4. Convenient determination of protein-binding DNA sequences using quadruple 9-mer-based microarray and DsRed-monomer fusion protein / Min-Jeong Kim, Pil Joong Chung, Tae-Ho Lee, Tae-Hoon Kim, Baek Hie Nahm, and Yeon-Ki Kim. 5. Analysis of specific protein-DNA interactions by bacterial one-hybrid assay / Marcus B. Noyes. 6. MITOMI : a microfluidic platform for in vitro characterization of transcription factor-DNA interaction / Sylvie Rockel, Marcel Geertz, and Sebastian J. Maerkl. 7. Detecting protein-protein interactions with the split-ubiquitin sensor / Alexander Dünkler, Judith Müller, and Nils Johnsson. 8. Genome-wide dissection of posttranscriptional and posttranslational interactions / Mukesh Bansal and Andrea Califano. 9. Linking cellular signalling to gene expression using EXT-encoded reporter libraries / Anna Botvinik and Moritz J. Rossner. 10. Sample preparation for small RNA massive parallel sequencing / Willemijn M. Gommans and Eugene Berezikov -- pt. II. Genomic components. 11. CAGE (cap analysis of gene expression) : a protocol for the detection of promoter and transcriptional networks / Hazuki Takahashi, Sachi Kato, Mitsuyoshi Murata, and Piero Carninci. 12. Detecting DNaseI-hypersensitivity sites with MLPA / Thomas Ohnesorg, Stefanie Eggers, and Stefan J. White. 13. Detecting long-range chromatin interactions using the chromosome conformation capture sequencing (4C-seq) method / Nele Gheldof, Marion Leleu, Daan Noordermeer, Jacques Rougemont, and Alexandre Reymond -- pt. III. Mapping protein-DNA interactions. 14. Analyzing transcription factor occupancy during embryo development using ChIP-seq / Yad Ghavi-Helm and Eileen E.M. Furlong. 15. Genome-wide profiling of DNA-binding proteins using barcode-based multiplex solexa sequencing / Sunil Kumar Raghav and Bart Deplancke. 16. Computational analysis of protein-DNA interactions from ChIP-seq data / Jacques Rougemont and Felix Naef. 17. Using a yeast inverse one-hybrid system to identify functional binding sites of transcription factors / Jizhou Yan and Shawn M. Burgess. 18. Using cisTargetX to predict transcriptional targets and networks in Drosophila / Delphine Potier, Zeynep Kalender Atak, Marina Naval Sanchez, Carl Herrmann, and Stein Aerts. 19. Proteomic methodologies to study transcription factor function / Harry W. Jarrett. 20. High-throughput gateway-compatible yeast one-hybrid screen to detect protein-DNA interactions / Korneel Hens, Jean-Daniel Feuz, and Bart Deplancke -- pt. IV. Visualization GRNs. 21. BioTapestry : a tool to visualize the dynamic properties of gene regulatory networks / William J.R. Longabaugh -- pt. V. Modeling of GRNs. 22. Implicit methods for qualitative modeling of gene regulatory networks / Abhishek Garg, Kartik Mohanram, Giovanni De Micheli, and Ioannis Xenarios.
- 2012 SpringerAhituv, Nadav.Gene regulatory elements / Nadav Ahituv -- Hemoglobin regulatory regions / Betty S. Pace and Levi H. Makala -- Regulatory polymorphisms and osteoporosis / Huilin Jin and Stuart H. Ralston -- Gene regulation in Van Buchem disease / Gabriela G. Loots -- Cis-regulatory enhancer mutations are a cause of human limb malformations / Julia E. VanderMeer and Nadav Ahituv -- Regulatory mutations leading to cleft lip and palate / Brian C. Schutte, Walid D. Fakhouri and Daniel Zemke -- Cis-regulatory disruption at the SOX9 locus as a cause of Pierre Robin sequence / Christopher T. Gordon, Sabina Benko, Jeanne Amiel and Stanislas Lyonnet -- Regulatory mutations in human hereditary deafness / Jonathan E. Bird and Thomas B. Friedman -- Contributions of RET noncoding variation to Hirschsprung disease / Zachary E. Stine and Andrew S. McCallion -- Cis-regulatory variation and cancer / Nora F. Wasserman and Marcelo A. Nobrega -- Cohesin and human diseases / Dongbin Xu and Ian D. Krantz -- Epigenetics and human disease / Angeliki Magklara and Stavros Lomvardas.
- 2005 CRCnetBASESohail, Muhammad.
- 2010 SpringerGiacca, Mauro.
- 2006 ScienceDirectNiewöhner, Jörg; Tannert, Christof.Also available: Print – 2006
- 2007 SpringerHunt, Kelly K.; Swisher, Stephen G.; Vorburger, Stephan A.Adenovector-mediated cancer gene therapy / Bingliang Fang and Jack A. Roth -- Efficacy, toxicity, and immunogenicity of adenoviral vectors / Dmitry M. Shayakhmetov -- Lentiviral and retroviral vector systems / Renata Stripecke and Noriyuki Kasahara -- Vaccinia and pox-virus / Sricharan Chalikonda and David L. Bartlett -- Herpes simplex virus as a therapy for cancer / Ian J. Mohr -- Alphavirus vectors for gene therapy applications / Kenneth Lundstrom -- Vesicular stomatitis virus and RNA viruses as gene therapy vectors / Glen N. Barber -- Parvovirus vectors / Selvarangan Ponnazhagan -- Nonviral vector systems / Pui-yan Lee and Leaf Huang -- Oncogenes, tumor suppressor genes, and apoptosis-inducing genes utilized in cancer gene therapy / Lidong Zhang and Bingliang Fang -- Gene silencing therapy against cancer / Chao-Zhong Song -- Tumor targeting-retargeted adenovirus / Masato Yamamoto and David T. Curiel -- Oncolytic herpes simplex for gene therapy in preclinical and clinical trials / Richard H. Pin ... [et al.] -- Cytokine gene therapy for genitourinary cancer / Terry L. Timme ... [et al.] -- Combination of gene therapy with radiation / Anupama Munshi and Raymond E. Meyn -- Gene transfer for chemoprotection and enrichment of hematopoietic stem cells / Justin C. Roth and Stanton L. Gerson -- Nonviral genetic vaccines for cancer / Steven R. Little, Daniel G. Anderson, and Robert Langer -- Gene therapy targeted at angiogenesis and lymphangiogenesis for cancer treatment / Anita T. Tandle and Steven K. Libutti -- Tumor-specific replicating adenoviruses : delta 24 for human gliomas / Giacomo G. Vecil, Juan Fueyo, and Frederick F. Lang -- Problems, side effects, and disappointments in clinical cancer gene therapy / Ta-Chiang Liu and David H. Kirn -- Trials and tribulations in developing clinical trials of gene therapy : E1A for breast or ovarian cancer / Naoto T. Ueno ... [et al.] -- Phase I clinical experience with intravenous administration of PV701, an oncolytic virus / Andrew L. Pecora and Robert M. Lorence -- MDA-7/IL-24 as a multi-modality therapy for cancer / Sunil Chada ... [et al.] -- Development of therapeutic genes for breast cancer treatment / Mien-Chie Hung and Duen-Hwa Yan -- Steps in a translational cancer gene therapy trial / Urs W. von Holzen and Stephen G. Swisher.Also available: Print – 2007
- 2015 SpringerBerkhout, Ben; Ertl, Hildegund C. J.; Weinberg, Marc S.Gene therapies for hepatitis C virus / Monique M.A. Verstegen, Qiuwei Pan, and Luc J.W. van der Laan -- Recent advances in use of gene therapy to treat hepatitis B virus infection / Kristie Bloom, Abdullah Ely, and Patrick Arbuthnot -- U1interference (U1i) for antiviral approaches / Lorea Blázquez and Puri Fortes -- Gene therapy strategies to block HIV-1 replication by RNA interference / Elena Herrera-Carrillo and Ben Berkhout -- HIV and ribozymes / Robert J. Scarborough and Anne Gatignol -- Editing CCR5: a novel approach to HIV gene therapy / Tatjana I. Cornu, Claudio Mussolino, Kristie Bloom, and Toni Cathomen -- Synthetic DNA approach to cytomegalovirus vaccine/immune therapy / Stephan J. Wu, Daniel O. Villarreal, Devon J. Shedlock, and David B. Weiner -- Vector-mediated antibody gene transfer for infectious diseases / Bruce C. Schnepp and Philip R. Johnson -- HIV latency and the non-coding RNA therapeutic landscape / Sheena Saayman, Thomas C. Roberts, Kevin V. Morris, and Marc S. Weinberg -- C peptides as entry inhibitors for gene therapy / Lisa Egerer, Hans-Peter Kiem, and Dorothee von Laer -- Aptamer-siRNA chimeras for HIV / Mayumi Takahashi, John C. Burnett, and John J. Rossi -- Index.
- 2008 KargerBenigni, Ariela; Remuzzi, Giuseppe.Renal diseases as targets of gene therapy / Phillips, B., Giannoukakis, N., Trucco, M. -- Non-viral gene delivery / Akital, H., Harashima, H -- Retrovirus vectors for gene delivery / Lech, P., Somia N.V -- Adenovirus vectors for renal targeted gene delivery / Appledorn, D.M., Seregin, S., Amalfitano, A. -- Adeno-associated virus vectors: versatile tools for in vivo gene transfer / Zentilin, L., Giacca, M. -- RNA interference in research and therapy of renal diseases / Rácz, Z., Hamar, P -- Gene therapy for acute renal failure / Torras, J., Cruzado, J.M., Grinyo, J.M -- Chronic deteriorating renal function and renal fibrosis / Isaka, Y., Takahara, S., Imai, E. -- Allograft rejection: acute and chronic studies / Tomasoni, S., Remuzzi, G., Benigni, A. -- Gene therapy for renal cancer / Haviv, Y.S., Curiel, D.T -- HIV-associated nephropathy / Wyatt, C.M., Rosenstiel, P.E., Klotman, P.E.Also available: Print – 2008
- 2005 SpringerPrud'homme, Gérald J.Gene therapy approaches for autoimmune diseases of the central nervous system and other tissues / Roberto Furlan ... [et al.] -- Gene therapeutics in autoimmune diabetes / Jon D. Piganelli, Massimo Trucco, and Nick Giannoukakis -- Immunogene therapy with nonviral vectors / Ciriaco A. Piccirillo, Argyrios N. Theofilopoulos, and Gérald J. Prud'homme -- Targeting antigen-specific T cells for gene therapy of autoimmune disease / Justin M. Johnson and Vincent K. Tuohy -- Therapeutic gene transfer for rheumatoid arthritis / Natacha Bessis and Marie-Christophe Boissier -- Gene therapy-based approach for immune tolerance induction using recombinant immunoglobulin carriers / Moustapha El-Amine ... [et al.] -- DNA vaccination against autoimmune diseases / Gérald J. Prud'homme ... [et al.].
- Gene therapy of cancer : translational approaches from preclinical studies to clinical implementation. Third edition [3rd ed.]2013 ClinicalKeyGerson, Stanton L.; Lattime, Edmund C.Ex Vivo Gene Therapy: Utilization of Genetic Vectors for the Generation of Genetically Modified Cell Products for Therapy -- Targeting Tumor Vasculature Using Adeno-Associated Virus Phage Vectors Coding Tumor Necrosis Factor-a -- Viral Insertion Site Detection and Analysis in Cancer Gene Therapy -- Targeted Systemic Delivery of Therapeutic siRNA -- Bacterial Delivery of RNAi Effectors -- Gene-Directed Enzyme Prodrug Cancer Therapy -- Electroporation Gene Therapy -- Toxin-Based Cancer Gene Therapy: Under the Control of Oncofetal H19 Regulatory Sequences -- Gene Therapy in Radiotherapy of Cancer -- Advances in Oncolytic Virotherapy for Brain Tumors -- Oncolytic Adenoviruses in the Treatment of Cancer in Humans -- Selectively Replicating Oncolytic Adenoviruses Combined with Chemotherapy, Radiotherapy, or Molecular Targeted Therapy for Treatment of Human Cancers -- Reoviral Therapy for Cancer: Strategies for Improving Antitumor Efficacy Using Radio- and Chemotherapy -- Selectively Replicating Herpes Simplex Viral Vectors -- Modified Oncolytic Herpesviruses for Gene Therapy of Cancer -- The Lister Strain of Vaccinia Virus as an Anticancer Therapeutic Agent -- Poxvirus-Based Strategies for Combined Vaccine and Tumor Microenvironment Manipulation -- Genetically Engineered (T Cell Receptor) T Cells for AdoptiveTherapy -- Genetically Modified Dendritic Cell Vaccines for Solid Tumors -- Dendritic Cell Vaccination -- Chemokine Gene-Modified Dendritic Cells for Cancer Therapy -- The Use of T Cell Costimulation to Enhance the Immunogenicity of Tumors -- Clinical Application of Plasmid-Based Cancer Vaccines -- Lentivector Vaccines -- Therapeutic Efficacy and Systemic Antitumor T Cell Immunity Induced by RheoSwitch-Regulated IL-12 Expression after Intratumoral Injection of Adenovirus Vector or Vector-Transduced Dendritic Cells -- Clinical Trials Using LV-P₁₄₀K-MGMT for Gliomas -- RNA Interference Therapeutics for Tumor Therapy: Promising Work in Progress -- MGMT Stem Cell Selection and Protection: Preclinical Large Animal and Clinical Studies -- Cytidine Deaminase in Myeloprotective Gene Therapy -- Genetically Engineered Salmonella typhimurium for Targeted Cancer Therapy -- Imaging of Oncolytic Virus Gene Expression -- Lentiviral-Encoded Sodium Iodide Symporter-Mediated Cancer Gene Therapy -- Bacteriophage: From Bacteria to a Successful Targeted Systemic Gene Delivery for Cancer -- Issues in Moving Gene Therapy Approaches to Early Clinical Trials -- The FDA Review Process for Cancer Gene Therapy -- Ethics in Translational Gene Transfer Research.
- 2009 KargerRyan, Allen F.Gene therapy for the inner ear : challenges and promises / Ryan, A.F., Dazert, S. -- Therapeutic regulation of gene expression in the inner ear using RNA interference / Maeda, Y., Smith, R.J.H. -- Gene therapy of the inner ear using adenovirus vectors / Husseman, J., Raphael, Y. -- Repair of the vestibular system via adenovector delivery of Atoh1 : a potential treatment for balance disorders / Baker, K., Brough, D.E., Staecker, H. -- Gene therapy and stem cell transplantation : strategies for hearing restoration / Kesser, B.W., Lalwani, A.K. -- Adenoviral and AAV-mediated gene transfer to the inner ear : role of serotype, promoter, and viral load on in vivo and in vitro infection efficiencies / Luebke, A.E. ... [et al.].Also available: Print – 2009
- 2015 Springer ProtocolsStein, Ulrike; Walther, Wolfgang.Aptamer targeting the ERBB2 receptor tyrosine kinase for applications in tumor therapy / Georg Mahlknecht, Michael Sela, and Yosef Yarden -- Gene gun her2/neu DNA vaccination : evaluation of vaccine efficacy in a syngeneic her2/neu mouse tumor model / Tam Nguyen-Hoai, Antonio Pezzutto, and Jörg Westermann -- MIDGE technology for the production of a fourfold gene-modified, allogenic cell-based vaccine for cancer therapy / Manuel Schmidt, Barbara Volz, Patrick Grossmann, Kerstin Heinrich, and Burghardt Wittig -- Evaluation of bystander cell killing effects in suicide gene therapy of cancer : engineered thymidylate kinase (TMPK)/AZT enzyme-prodrug axis / Takeya Sato, Anton Neschadim, Ryo Nakagawa, Teruyuki Yanagisawa, and Jeffrey A. Medin -- Oncoleaking : use of the pore-forming Clostridium perfringens enterotoxin (CPE) for suicide gene therapy / Jessica Pahle, Jutta Aumann, Dennis Kobelt, and Wolfgang Walther -- iCaspase 9 suicide gene system / Xiaoou Zhou, Antonio Di Stasi, and Malcolm K. Brenner -- p53-encoding pDNA purification by affinity chromatography for cancer therapy / Ângela Sousa, João A. Queiroz, and Fani Sousa -- Phase 2, open-label, randomized study of pexa-vec (JX-594) administered by intratumoral injection in patients with unresectable primary hepatocellular carcinoma / Caroline J. Breitbach, Anne Moon, James Burke, Tae-Ho Hwang, and David H. Kirn -- Antiangiogenic metargidin peptide (AMEP) tene therapy in disseminated melanoma / Iben Spanggaard and Julie Gehl -- Clinical evaluation of ErbB-targeted CAR T-cells, rollowing intracavity delivery in patients with ErbB-expressing solid tumors / Sophie Papa, May van Schalkwyk, and John Maher.
- 2006 ScienceDirectDuring, Matthew J.; Kaplitt, Michael G.
- v. 1-, 2008- Springer ProtocolsLe Doux, Joseph M.v. 1. Production and in vivo applications of gene transfer vectors. Preparation and quantification of pseudotyped retroviral vector / Hong Yu and Young Jik Kwon. Production of retroviral vectors for clinical use / Kenneth Cornetta, Lilith Reeves, and Scott Cross. Methods for the production of helper-dependent adenoviral vectors / Donna J. Palmer and Philip Ng. Methods for the production of first generation adenoviral vectors / Donna J. Palmer and Philip Ng. Large-scale production of recombinant adeno-associated viral vectors / Alejandro Negrete and Robert M. Kotin. Construction and production of recombinant herpes simplex virus vectors / William F. Goins ... [et al.] Plasmid-based gene transfer in mouse skeletal muscle by electroporation / Jonathan D. Schertzer and Goron S. Lynch. Chitosan nanoparticle-mediated gene transfer / Dongwon Lee and Shyam S. Mohapatra. PEG-PEI copolymers for oligonucleotide delivery to cells and tissues / Gordon J. Lutz, Shashank R. Sirsi, and Jason H. Williams. Non-viral gene delivery with cationic liposome-DNA complexes / Kai K. Ewert ... [et al.] Applications of lentiviral vectors in noninvasive molecular imaging / Abhijit De ... [et al.] Retroviral modification of mesenchymal stem cells for gene therapy of hemophilia A / Christopher B. Doering. Transduction of murine hematopoietic stem cells and in vivo selection of gene-modified cells / Lucienne M. Ide, Elisabeth Javazon, and H. Trent Spencer. Assessment of CFTR function after gene transfer in vitro and in vivo / Uta Griesenbach ... [et al.] Oncolytic adenoviruses for cancer gene therapy / Ta-Chiang Liu, Stephen H. Thorne, and David H. Kirn. Design of trans-splicing adeno-associated viral vectors for Duchenne muscular dystrophy gene therapy / Yi Lai ... [et al.] Prevention of type 1 diabetes in NOD mice by genetic engineering of hematopoietic stem cells / Jessamyn Bagley, Charoui Tian, and John Iacomini. Lentiviral vector delivery of siRNA and shRNA encoding genes into cultured and primary hematopoietic cells / Mingjie Li and John J. Rossi. Nanoparticle-mediated gene delivery to the lung / Rajagopal Ramesh. Retroviral-mediated gene therapy for the differentiation of primary cells into a mineralizing osteoblastic phenotype / Jennifer E. Phillips and Andrés J. García. In vivo siRNA delivery to the mouse hypothalamus shows a role of the co-chaperone XAP2 in regulating TRH transcription / Stéphanie Decherf, Zahra Hassani, and Barbara A. Demeneix. Efficient retroviral gene transfer to epidermal stem cells / Pedro Lei and Stelios T. Andreadis.
- 2003 ScienceDirectMakrides, Savvas C.Also available: Print – 2003
- 2012 ScienceDirectFriedmann, Theodore.General principles of retrovirus vector design / Tammy Chang and Jiing-Kuan Yee -- Strategies for retrovirus-based correction of severe, combined immunodeficiency (SCID) / Alain Fischer, Salima Hacein-Bey-Abina, and Marina Cavazzana-Calvo -- Retrovirus and lentivirus vector design and methods of cell conditioning / Samantha Cooray, Steven J. Howe, and Adrian J. Thrasher -- Analysis of the clonal repertoire of gene-corrected cells in gene therapy / Anna Paruzynski ... [et al.] -- Developing novel lentiviral vectors into clinical products / Anna Leath and Kenneth Cornetta -- Lentivirus vectors in [beta]-thalassemia / Emmanuel Payen ... [et al.] -- Gene therapy for chronic granulomatous disease / Elizabeth M. Kang and Harry L. Malech -- Alternative splicing caused by lentiviral integration in the human genome / Arianna Moiani and Fulvio Mavilio -- Genotoxicity assay for gene therapy vectors in tumor prone mice / Eugenio Montini and Daniela Cesana -- Lentiviral hematopoietic cell gene therapy for X-linked adrenoleukodystrophy / Nathalie Cartier ... [et al.] -- Retroviral replicating vectors in cancer / Christopher R. Logg ... [et al.] -- Adeno-associated virus vectorology, manufacturing, and clinical applications / Joshua C. Grieger and R. Jude Samulski -- Gene delivery to the retina : from mouse to man / Jean Bennett, Daniel C. Chung, and Albert Maguire -- Generation of hairpin-based RNAi vectors for biological and therapeutic application / Ryan L. Boudreau and Beverly L. Davidson -- Recombinant adeno-associated viral vector reference standards / Philippe Moullier and Richard O. Snyder -- NIH oversight of human gene transfer research involving retroviral, lentiviral, and adeno-associated virus vectors and the role of the NIH Recombinant DNA Advisory Committee / Marina O'Reilly ... [et al.] -- Regulatory structures for gene therapy medicinal products in the European Union / Bettina Klug ... [et al.].
- 2012 SpringerScheiblhofer, Sandra; Thalhamer, Josef; Weiss, Richard D.
- 2010 SpringerRoth, Jack A.
- 2015 SpringerAlexiou, Athanasios; Vlamos, Panayiotis.The 1st World Congress on Geriatrics and Neurodegenerative Disease Research (GeNeDis 2014) focused on recent advances in geriatrics and neurodegeneration, ranging from basic science to clinical and pharmaceutical developments providing an international forum for the latest scientific discoveries, medical practices and care initiatives. This volume focuses on the bioinformatics and computational biology-related sessions
- 2015 SpringerAlexiou, Athanasios; Vlamos, Panayiotis.The 1st World Congress on Geriatrics and Neurodegenerative Disease Research (GeNeDis 2014), will focus on recent advances in geriatrics and neurodegeneration, ranging from basic science to clinical and pharmaceutical developments and will provide an international forum for the latest scientific discoveries, medical practices and care initiatives. Advances information technologies will be discussed along with their implications for various research, implementation and policy concerns. In addition, the conference will address European and global issues in the funding of long-term care and medico-social policies regarding elderly people. GeNeDis 2014 takes place in Corfu, Greece, 10-13 April 2014. This volume focuses on the sessions that address geriatrics.
- 2015 SpringerAlexiou, Athanasios; Vlamos, Panayiotis.The 1st World Congress on Geriatrics and Neurodegenerative Disease Research (GeNeDis 2014) focused on recent advances in geriatrics and neurodegeneration, ranging from basic science to clinical and pharmaceutical developments providing an international forum for the latest scientific discoveries, medical practices and care initiatives. Advanced information technologies were discussed along with their implications for various research, implementation and policy concerns. This volume focuses on neurodegenerative disease sessions.
- 2009Cross, Simon S.; Underwood, J. C. E.Introduction to pathology / J.C.E. Underwood -- Characteristics, classification, and incidence of disease / J.C.E. Underwood -- Genetic, environmental, and infectious causes of disease / J.C.E. Underwood -- Diagnostic pathology in clinical practice / S.S. Cross -- Disorders of growth, differentiation, and morphogenesis / J.P. Bury -- Response to cellular injury / J.R. Goepel -- Disorders of metabolism and homeostasis / J.C.E. Underwood -- Ischaemia, infarction, and shock / S.S. Cross -- Immunology and immunopathology / M.R. Haeney -- Inflammation / T.J. Stephenson -- Carcinogenesis and neoplasia / J.C.E. Underwood -- Ageing and death / J.C.E. Underwood -- Cardiovascular system / P.J. Gallagher, A.C. van der Wal -- Respiratory tract / W.A.H. Wallace -- Alimentary system / M.F. Dixon -- Liver, biliary system, and exocrine pancreas / J.C.E. Underwood -- Endocrine system / T.J. Stephenson -- Breast / R.A. Walker -- Female genital tract / M. Wells -- Urinary and male genital tracts / J.R. Goepel -- Kidney diseases / J.R. Shortland -- Lymph nodes, thymus, and spleen / K.A. MacLennan -- Blood and bone marrow / D.J. Culligan, H.G. Watson -- Skin / D.N. Slater -- Osteoarticular and connective tissues / D.E. Hughes -- Central and peripheral nervous systems / J.W. Ironside.
- 2007 ClinicalKeyMiddleton, William D.Part of the popular Case Review series, this outstanding Board review book presents over 200 unknown cases--complete with over 350 state-of-the-art images, questions, answers, commentary, references, and more--to enhance your imaging interpretation skills in general and vascular ultrasound. Discussions incorporate the most recent knowledge from the literature in this field, providing an excellent review for both residents and practitioners. Follows the format of the Boards, and offers case studies similar to those likely to be found on exams, for a realistic preparation for the test-taking experience. Presents cases in 3 overall categories--from least to most difficult--to build your skills in a cumulative way. Offers cross references to Ultrasound: The Requisites, 2nd Edition, so it's easy to find in-depth information on any subject.
- Middleton, William D.
- Middleton, William D.
- 2007 SpringerCiancio, A.; Mukerji, K. G.
- 2009 ClinicalKeyKo, Christine J.; Schwarzenberger, Kathryn; Werchniak, Andrew E."This title in the Requisites in Dermatology series is the perfect resource for quick reference and rapid review in general dermatology. It succinctly presents all of the most essential clinical and foundational knowledge you need for certification, recertification, or practice. An extremely user-friendly full-color format, replete with full-color clinical photographs and other pertinent illustrations, makes it easy to locate and read up on any topic. Plus, full-text online access lets you consult the book from any computer, download all of the images, watch online lectures, and more."--Jacket.
- 2007Sokol, Andrew I.; Sokol, Eric R.
- 2010 CRCnetBASEGuo, Lei; Men, Jiuzhang.Established by the Western Han dynasty more than 2,000 years ago, Traditional Chinese Medicine (TCM) is currently finding increased acceptance. Explores the thinking behind TCM, its philosophy-based theory, and its cutting-edge uses in today's clinical practice. Complete with chapter outlines and ancillary material, this carefully designed guide brings a time-tested practice back to the future.
- 2008 SpringerHayat, M. A.
- Asbury, Taylor; Cunningham, Emmett T.; Riordan-Eva, Paul; Vaughan, Daniel; Whitcher, John.Also available: Print – 2004-<2011>
- 2010 SpringerHayat, M. A.
- v. 1, 1948.Büchner, Franz; Letterer, Erich; Meessen, Hubert.
- 2012 Thieme BookSteffers, Gabriele; Credner, Susanne.
- 2013 SpringerIyer, K. Mohan.
- 2007 SpringerKaufman, Howard L.; Wolchok, Jedd D.General principles of tumor immunology -- A perspective on cancer immunology and immunotherapy -- Tumor antigens -- T cells and antigen recognition -- The role of natural killer T cells in tumor immunity -- Immunomodulatory molecules of the immune system -- HLA class I antigen abnormalities in tumors -- The local tumor microenvironment -- Tumor vaccines -- Peptide and protein vaccines for cancer -- DNA vaccines against cancer -- Recombinant viral and bacterial vaccines -- Dendritic cell vaccines -- Whole cell vaccines -- Carbohydrate vaccines against cancer -- Passive immunotherapy approaches -- Monoclonal antibody therapy of cancer -- Adoptive cellular therapy for the treatment of cancer -- Checkpoint blockade and combinatorial immunotherapies -- Clinical tumor immunotherapy -- General approaches to measuring immune responses -- Interferon therapy -- High dose interleuken-2 therapy -- Monoclonal antibodies in cancer therapy -- Unmasking tumor cell immunogenicity by chemotherapy: implications for therapy.
- 2014 SpringerCoventry, Brendon J.Written by internationally acclaimed specialists, General Surgery Risk Reduction expands on complications associated with surgery and how to reduce them, the availability of relevant information and the rapid advancements of surgical technology. Chapters provide pertinent and concise procedure descriptions creating a book that is both comprehensive and accessible. Stages of operative approaches with relevant technical considerations are outlined in an easily understandable manner. Complications are reviewed when appropriate for the organ system and problem. The text is illustrated throughout by line drawings and photographs that depict anatomic or technical principles. Forming part of the series, Surgery: Complications, Risks and Consequences, this volume General Surgery Risk Reduction provides a valuable resource for all general surgeons and residents in training. Other healthcare providers will also find this a useful resource.
- 2009 OvidFeins, Richard H.; LoCicero, Joseph; Reed, Carolyn E.; Shields, Thomas W.Anatomy of the chest thorax -- Embryology of the lungs -- Ultrastructure and morphometry of the human lung -- Cellular and molecular biology of the lung -- Surgical anatomy of the lungs -- Lymphatics of the lungs -- Pulmonary gas exchange -- Mechanics of breathing -- Radiographic evaluation of the lungs and chest -- Computed tomography of the lungs, pleura, and chest wall -- Magnetic resonance imaging of the thorax -- Positron emission tomography in chest diseases -- Radionuclide studies of the lung -- Ultrasound techniques in mediastinal, lung, and esophageal disease -- Laboratory investigations in the diagnosis of pulmonary diseases -- Diagnostic studies in lung cancer -- Bronchoscopic evaluation of the lungs and tracheobronchial tree -- Invasive diagnostic procedures -- Video-assisted thoracic surgery as a diagnostic tool -- Pulmonary physiologic assessment of operative risk -- Preoperative cardiac evaluation of the thoracic surgical patient -- Conduct of anesthesia -- The shared airway: management of the paitent with airway pathology -- Anesthesia for pediatric general thoracic surgery -- Thoracic incisions -- General features of pulmonary resections -- Thoracic surgery in the elderly -- Technical aspects of lobectomy -- Sleeve lobectomy -- Pneumonectomy and its modifications -- Tracheal sleeve pneumonectomy -- Segmentectomy and lesser pulmonary resections -- Instruments and techniques of video-assisted thoracic surgery -- Robotic-assisted surgery in thoracic diseases -- Video-assisted thoracic surgery for wedge resection, lobectomy, and pneumonectomy -- Median sternotomy and parasternal approaches to the lower trachea and mainstem bronchi -- Concomitant cardiac and pulmonary operations -- Anterior approach to superior sulcus lesions -- Complications of pulmonary resection -- Management of perioperative cardiac events -- General principles of postoperative care -- Mechanical ventilation of the surgical patient -- Chest wall deformities -- Lung hernias of the chest wall -- Infections of the chest wall -- Thoracic outlet syndrome (with transaxillary, supraclavicular, posterior, and VATS approaches) -- Thoracoscopic sympathectomy -- Anterior transthoracic approaches to the spine -- Chest wall tumors -- Chest wall reconstruction -- Embryology and anatomy of the diaphragm -- Pacing of the diaphragm -- Congenital posterolateral diaphragmatic hernias and other less common hernias of the diaphragm in infants and children -- Foramen of morgagni hernia -- Tumors of the diaphragm -- Anatomy of the pleura -- Resorption of gases from the pleural space -- Pneumothorax -- Physiology of pleural fluid production -- Benign pleural effusion -- Parapneumonic empyema -- Postsurgical empyema -- Tuberculous and fungal infections of the pleura -- Fibrothorax and decortication of the lung -- Thoracoplasty: indications and surgical considerations -- Anatomy of the thoracic duct and chylothorax -- Localized fibrous tumors of the pleura -- Diffuse malignant mesothelioma -- Technique of extrapleural pneumonectomy for diffuse malignant pleural mesothelioma -- Uncommon tumors of the pleura -- Malignant pleural effusions -- Malignant pericardial effusions -- Blunt and penetrating injuries of the chest wall, pleura, and lungs -- Barotrauma and inhalation injuries -- Acute respiratory distress syndrome -- Management of foreign bodies of the airway -- Diaphragmatic injuries -- Tracheostomy -- Surgical anatomy of the trachea and techniques of resection and reconstruction -- Management of nonneoplastic diseases of the trachea -- Benign and malignant tumors of the trachea -- Compression of the trachea by vascular rings -- Congenital lesions of the lung -- Pulmonary complications of cystic fibrosis -- Congenital vascular lesions of the lungs -- Chronic pulmonary emboli -- Bullous and bleb diseases of the lung -- Lung volume reduction -- Bacterial infections of the lungs and bronchial compressive disorders -- Pulmonary tuberculosis and other mycobacterial diseases of the lung -- Surgery for the management of mycobacterium tuberculosis and nontuberculous mycobacterial (environmental) infections of the lung -- Mycotic and actinomycetic infections of the lung -- Pleuropulmonary amebiasis -- Hydatied disease of the lung -- Pulmonary paragonimiasis and its surgical complications -- Solitary pulmonary nodule -- Diffuse lung disease -- Lung transplantation -- Evidence-based thoracic surgery -- Clinical trial design -- Lung cancer: epidemiology and carcinogenesis -- Screening for lung cancer: challenges for thoracic surgery -- Investigation and management of the nodules less than one centimeter in size -- Pathology of carcinoma of the lung -- The sentinel lymph node in non-small-cell carcinoma of the lung -- Present concepts in the molecular biology of lung cancer -- Clinical presentation of lung cancer -- Radiologic evaluation of lung cancer -- Diagnosis and staging of lung cancer -- Surgical treatment of non-small-cell lung cancer -- Lymph node dissection for lung cancer -- Unknown primary malignancy metastatic to thoracic lymph nodes -- Endoluminal management of malignant airway disease -- Basic principles of radiation therapy in locally advanced carcinoma of the lung -- Radiation therapy for carcinoma of the lung -- Adjuvant chemotherapy for non-small-cell lung cancer -- Neoadjuvant therapy for non-small-cell lung cancer -- Novel systemic therapy for advanced non-small-cell lung cancer -- Emerging technologies and techniques for the management of non-small-cell lung cancer -- Small-cell lung cancer -- Novel strategies for lung cancer immunotherapy -- Carcinoid tumors -- Adenoid cystic carcinoma and other primary salivary gland-type tumors of the lung -- Benign tumors of the lung -- Uncommon primary malignant tumors of the lung -- Secondary tumors of the lung -- Lung tumors in the immunocompromised host -- Embryology of the esophagus -- Anatomy of the esophagus -- Lymphatic drainage of the esophagus -- Physiology and physiologic studies of the esophagus -- Esophageal pH studies in esophageal disease -- Radiologic evaluation of the esophagus -- Endoscopy of the esophagus -- Modified heller myotomy -- Transthoracic resection of the esophagus -- Extended resection for esophageal carcinoma -- Transhiatal esophagectomy without thoracotomy -- Vagal-sparing esophagectomy -- Video-assisted esophageal resection -- Replacement of the esophagus with colon -- Replacement of the esophagus with jejunum -- Free intestinal transfer techniques in reconstruction of the esophagus -- Esophageal stents -- Foreign bodies in the esophagus -- Esophageal trauma -- Congenital anomalies of the esophagus -- Inflammatory diseases of the esophagus -- Esophageal motility disorders -- Chagas' disease of the esophagus -- Surgical therapy for gastroesophageal reflux disease -- Barrett's esophagus -- Esophageal endoscopic procedures in thoracic surgery -- Cardial incompetence and associated gastroesophageal reflux -- Paraesophageal hiatal hernia -- Esophageal diverticula -- Benign tumors, cysts, and duplications of the esophagus -- Carcinoma of the esophagus -- Appendix: 2009 AJCC/UICC staging of esophageal cancer -- Multimodality therapy for esophageal cancer -- Surgical palliation of inoperable carcinoma of the esophagus -- Less common malignant tumors of the esophagus -- The mediastinum, its compartments, and the mediastinal lymph nodes -- The thymus -- Mediastinal parathyroids -- Neurogenic structures of the mediastinum -- Radiographic, computed tomographic, and magnetic resonance investigation of the mediastinum -- Radionuclide studies of the mediastinum -- Mediastinal tumor markers -- Transcervical mediastinal lymph node sampling and lymphadenectomy -- Sternotomy and thoracotomy for mediastinal disease -- Video-assisted thoracic surgery for diseases within the mediastinum -- Primary pneumomediastinum -- Acute and chronic mediastinal infections -- Primary mediastinal tumors and cysts and diagnostic investigation of mediastinal masses -- Lesions masquerading as primary mediastinal tumors or cysts -- Vascular masses of the mediastinum -- Superior vena cava syndrome: clinical features, diagnosis, and treatment -- Vein grafts for the superior vena cava -- The use of prosthetic grafts to replace the superior vena cava -- Myasthenia gravis -- Pathophysiology of myasthenia gravis -- Standard thymectomy -- Transcervical thymectomy -- Video-assisted thymectomy -- Extended transsternal thymectomy -- Transcervical-transsternal maximal thymectomy for myasthenia gravis -- Evaluation of results of thymectomy for nonthymomatous myasthenia gravis -- Thymic tumors -- Benign lymph node disease involving the mediastinum -- Biological markers and pathology of mediastinal lymphomas -- Diagnosis and treatment of mediastinal lymphomas -- Benign germ cell tumors of the mediastinum -- Primary seminomas of the mediastinum -- Nonseminomatous malignant germ cell tumors of the mediastinum -- Poorly differentiated carcinoma of the mediastinum -- Benign and malignant neurogenic tumors of the mediastinum in children and adults -- Excision of hourglass tumors of the paravertebral sulcus -- Mediastinal paragangliomas and pheochromocytomas -- Mesenchymal tumors of the mediastinum -- Mediastinal parathyroid tumors -- Foregut cysts of the mediastinum in infants and children -- Foregut cysts of the mediastinum -- Gastroenteric cysts and neuroenteric cysts in infants and children -- Mesothelial and other less common cysts of the mediastinum.
- 2005 OvidLoCicero, Joseph; Ponn, Ronald B.; Shields, Thomas W.
- 2014 SpringerOestern, H.-J; Trentz, O.; Uranues, Selman.All European countries, including those that have recently joined the European Union or are candidates for membership, currently show a clear trend towards an increasing number of accidental injuries. This holds true for a range of injuries, including accidents among the elderly, sports injuries, and trauma due to traffic accidents. The increase in the number of injuries is accompanied by rising expectations among patients, who anticipate good functional results even after serious injuries. Despite these developments, trauma surgery is not yet established as an independent field in all European countries. Against this background, there is a clear need for a book that covers the state of the art in trauma surgery. This volume, which focuses on basics in trauma surgery is intended to help to meet this need. It will also serve to harmonize the practice of trauma surgery within the European Union and to prepare for the UEMS EBSQ trauma surgery.
- 2005 SpringerLichtenstein, Daniel.
- Wood, Simon N.
- 2009 SpringerPortman, Michael E.Foreword by John H. Riskind -- Preface.-1. Nature of Generalized Anxiety Disorder.-2. Assessment and Diagnosis -- DSM-IV-TR: Diagnostic Criteria for Generalized Anxiety Disorder.-3. Conceptual Models -- Beck's Model -- Barlow's Emotion Theory -- Cognitive Avoidance Theory of Worry -- Riskind's Model of Looming Vulnerability -- The Role of Intolerance of Uncertainty -- Metacognitive Model.-4. Psychosocial Treatments for Adults with Generalized Anxiety Disorder -- Cognitive Behavioral Therapy (CBT). Metacognitive Therapy -- Supportive-Expressive Psychodynamic Therapy -- Integrative Psychotherapy -- Emotion Regulation Therapy -- Acceptance-Based Behavior Therapy.-5. Pharmacotherapy for Generalized Anxiety Disorder -- Genetics -- Neurobiology -- Medications used for Generalized Anxiety Disorder.-6. Special Populations -- Children and Adolescents -- Clinical Presentation -- Assessment and Diagnosis -- Psychosocial Treatments -- Pharmacological Treatments -- Older Adults -- Clinical Presentation -- Assessment and Diagnosis -- Psychosocial Treatments -- Pharmacological Treatments.-7. Enigmas and Paradoxes -- Prevention -- Cultural Considerations -- Treatment Resistant Generalized Anxiety Disorder.-8. Future Directions and Recommendations.-Final Remarks.Appendix A: Assessment Tools for Adults and Older Adults -- Appendix B: Assessment Tools for Children and Adolescents.
- 2006 CRCnetBASELee, Youngjo; Nelder, John A.; Pawitan, Yudi.
- 2003 Springer ProtocolsYing, Shao-Yao.Complementary DNA libraries: an overview / Shao-Yao Ying -- Rapid amplification of cDNA ends / Yue Zhang -- cDNA generation on paramagnetic beads / Zhaohui Wang and Michael G.K. Jones -- Construction of a normalized cDNA library by mRNA-cDNA hybridization and subtraction / Ye-Guang Chen -- Amplification of cDNA ends using PCR suppression effect and step-out PCR / Mikhail V. Matz [and others] -- Use of inverse PCR to clone cDNA ends / Sheng-He Huang, Steven H.M. Chen, and Ambrose Y. Jong -- Construction of size-fractionated cDNA library assisted by an in vitro recombination reaction / Osamu Ohara -- Construction of a full-length enriched and 5'-end enriched cDNA library using the oligo-capping method / Yutaka Suzuki and Sumio Sugano -- cDNA library construction using in vitro transcriptional amplification / Shi-Lung Lin and Henry Ji -- Amplification of representative cDNA pools from microscopic amounts of animal tissue / Mikhail V. Matz -- Single cell cDNA library construction using cycling aRNA amplification / Shi-Lung Lin -- mRNA/cDNA library construction using RNA-polymerase cycling reaction / Shi-Lung Lin and Shao-Yao Ying -- Quality assessment of cDNA libraries / Hans-Jürgen Fülle -- Assessment of the quality of mRNA libraries by agarose gel electrophoresis / Tsen-Yin Lin and Shao-Yao Ying -- PACS RT-PCR: a method for the generation and measurement of any poly(A)-containing mRNA not affected by contaminating genomic DNA / Igor Nepluev and Rodney J. Folz -- Single-cell mRNA library analysis by northern blot hybridization / Shi-Lung Lin -- Generation of cDNA libraries for profiling gene expression of given tissues or cells / Xin Zhang, Qiu-Hua Huang, and Ze-Guang Han -- Screening poly (dA/dT( -- )) cDNA for gene identification / San Ming Wang [and others] -- Generation of longer cDNA fragments from SAGE tags for gene identification / Jian-Jun Chen [and others] -- Generation of full-length cDNA libraries enriched for differentiatlly expressed genes / Bakhyt Zhumabayeva [and others] -- Subtractive hybridization for the identification of differentially expressed genes using uracil-DNA glycosylase and mung-bean nuclease / Tsen-Yin Lin and Shao-Yao Ying -- Subtractive cloning of differential genes using RNA-PCR / Shao-Yao Ying and Shi-Lung Lin -- Strategy for construction of a cDNA encoding a repetitive amino acid sequence / Masahiro Asada and Toru Imamura -- Preparing lambda libraries for expression of proteins in prokaryotes or eukaryotes / Rebecca L. Mullinax and Joseph A. Sorge -- Peptide library construction from RNA-PCR-derived RNAs / Shi-Lung Lin -- Identifying interacting proteins in an Escherichia coli-based two-hybrid system / Bonnie Wu, Rebecca L. Mullinax, and Joseph A. Sorge -- Future perspectives / Shao-Yao Ying.
- 2005/2006Sen, George L.
- 2014Greene, Jeremy A.Generic drugs are now familiar objects in clinics, drugstores, and households around the world. We like to think of these tablets, capsules, patches, and ointments as interchangeable with their brand-name counterparts: why pay more for the same? And yet they are not quite the same. They differ in price, in place of origin, in color, shape, and size, in the dyes, binders, fillers, and coatings used, and in a host of other ways. Claims of generic equivalence, as physician-historian Jeremy Greene reveals, are never based on being identical to the original drug in all respects, but in being the same in all ways that matter. How do we know what parts of a pill really matter? Decisions about which differences are significant and which are trivial in the world of therapeutics are not resolved by simple chemical or biological assays alone. Questions of therapeutic similarity and difference are also always questions of pharmacology and physiology, of economics and politics, of morality and belief. Greene chronicles the social, political, and cultural history of generic drugs, narrating the evolution of the generic drug industry from a set of mid-twentieth-century "schlock houses" and "counterfeiters" into an agile and surprisingly powerful set of multinational corporations in the early twenty-first century. The substitution of bioequivalent generic drugs for more expensive brand-name products is a rare success story in a field of failed attempts to deliver equivalent value in health care for a lower price. Greene's history sheds light on the controversies shadowing the success of generics: problems with the generalizability of medical knowledge, the fragile role of science in public policy, and the increasing role of industry, marketing, and consumer logics in late-twentieth-century and early twenty-first century health care.
- 2014 CRCnetBASEKanfer, Isadore; Shargel, Leon."This book collects in-depth discussions from more than 30 noted specialists on topics such as quality control, experimental formulations, pharmaceutical ingredients, conventional and modified-release products, and bioequivalence. It considers key elements in the formulation of generic drug products including the availability of raw materials and chemical purity. It contains new chapters on experimental formulation development, and the relationship between the FDA and the United States Pharmacopeia"--Provided by publisher.
- <1988>.Beers, Donald O.
- 2011 SpringerDhalla, Naranjan S.; Nagano, Makoto; Ošt̕ádal, Bohuslav.pt. 1. Genes and the heart -- pt. 2. Development and gender -- pt. 3. Mitochondrial diseases -- pt. 4. Ischemic heart disease -- pt. 5. Hypertension and arrhythmias -- pt. 6. Hypertrophy and failure.
- 2007 SpringerLewis, Edward B.; Lipshitz, Howard D.
- 2008Lewin, Benjamin.
- 2010 SpringerLeigh, Hoyle.Genes and mental illness -- How does stress work? the role of memes in epigenesis -- Culture and mental illness -- Genetic-memetic model of mental illness-migration and natural disasters as illustrations -- What do we inherit from our parents and ancestors? -- Genes -- Evolution -- Learning, imitation, and memes -- Storage and evolution of memes in the brain -- External storage of memes: culture, media, cyberspace -- Culture and the individual -- What is mental health -- What is mental illness? -- Psychiatric diagnosis: toward a memetic-epigenetic multiaxial model -- Memetic diagnosis, memetic assessment and biopsychosocial epigenetic formulation -- Principles of memetic therapy -- Broad-spectrum memetic therapy -- Specific memetic therapies -- Genetic-memetic prevention -- Overview of specific syndromes -- Attention-cognition spectrum syndromes: delirium, dementia, impulse control syndromes, ADHD, antisocial personality, obsessive-compulsive personality traits, obsessive-compulsive syndrome -- Anxiety-mood spectrum syndromes: anxiety, panic, phobias, ASD, PTSD, borderline syndrome, dependent and avoidant personalities, social phobia, bipolarity and mania, depression-neurotic and syndromic, adjustment disorders -- Reality perception spectrum syndromes (imagination, dissociation, conversion, somatoform, misattribution somatization, psychosis) -- Pleasure spectrum syndromes (substance use/abuse, additions to substances and beliefs, fanaticism) -- Primary memetic syndromes: eating disorders, factitious disorders, malingering, meme-directed destructive behaviors -- Challenges for the future.
- 2006Haines, Jonathan L.; Pericak-Vance, Margaret Ann.
- 2011Moore, Christopher Jason; Cohen, Stanley N.; Fire, Andrew Z.; Kay, Mark A.; Stearns, Tim.
- 2012Rack, Paul George; Chen, James; Kuo, Calvin Jay; Meyer, Tobias; Wandless, Thomas.The activation of the Hedgehog (Hh) pathway leading to Gli-dependent transcription plays critical roles in tissue patterning, homeostasis, and transformation. Despite the initial discovery of the pathway 30 years ago, a complete mechanistic understanding of Hh signal transduction remains elusive. By conducting a genome-scale overexpression screen using mammalian open reading frames (ORFs), I have identified the Rho GAP domain-containing protein Arhgap36, the homeodomain-interacting protein kinase Hipk4, and MED26, a subunit of the Mediator complex, as regulators of Gli function. This study represents the first report describing a functional role of Arhgap36 in any signaling process, and demonstrates Hipk4 modulates the cellular response to Hh ligand. The activity of MED26 was revealed in the context of the small molecule Hedgehog Pathway Inihibitor-1 (HPI-1), giving further insight to its mechanism of action. In addition, we describe the relevant mechanism of action of the small molecule JK184, a microtubule-disrupting agent that can have both positive and negative effects on pathway activity, depending on the nature of pathway perturbation. These findings provide new insights into how cells regulate Gli-dependent transcription and suggest strategies for the therapeutic intervention of Hh pathway-dependent disease.
- 2013 SpringerLentzsch, Suzanne.This state-of-the-art book is written by a group of international experts to provide insight into the newest breakthroughs from basic pathogenesis to clinical aspects of multiple myeloma. The book provides a comprehensive overview of the genetic and molecular epidemiology of multiple myeloma in order to get a more refined and conclusive understanding of this disease. Areas, which are covered include the characterization of different myeloma entities by genomics and proteomics, notch signaling and targeting protein translation as a new treatment for multiple myeloma, cell cycle control of plasma cell differentiation, the role of bone disease in the pathogenesis of multiple myeloma as well as the molecular interaction of multiple myeloma with a microenvironment. Genetic and Molecular Epidemiology of Multiple Myeloma is a valuable resource for cancer researchers, medical, surgical, and radiation oncologists.
- 2009/2010Garrison, Ná́ní́baa' Angela.
- 2007 SpringerGaultier, C.1. Respiratory control disorders: from genes to patients and back / David Gozal -- 2. Hereditary aspects of respiratory control in health and disease in humans / John V. Weil -- 3. Phox2b and the homeostatic brain / Jean-François Brunet and Christo Goridis -- 4. Congenital central hypoventilation syndrome: from patients to gene discovery / Ha Trang -- 5. Structural and functional brain abnormalities in congenital central hypoventilation syndrome / Ronald M. Harper... [et al.] -- 6. In vitro study of Pho2xb gene mutations in congenital central hypoventilation syndrome / Tiziana Bachetti and Isabella Ceccherini -- 7. Sudden infant death syndrome: study of genes pertinent to cardiorespiratory and autonomic regulation / Debra E. Weese-Mayer... [et al.] -- 8. The genetic basis for obstructive sleep apnea: what role for variation in respiratory control? / Susan Redline, Sanjay R. Patel -- 9. Apnea and irregular breathing in animal models: a physiogenomic approach / Motoo Yamauchi ... [et al.] -- 10. Genetic determinants of respiratory phenotypes in mice / Clarke G. Tankersley -- 11. Genes and development of respiratory rhythm generation / Jean Champagnat... [et al.] -- 12. Transcription factor control of central respiratory neuron development / Bruno C. Blanchi and Michael H. Sieweke -- 13. Lessons from mutant newborn mice with respiratory control deficits / Claude Gaultier -- 14. Tentative mouse model for the congenital central hypo-ventilation syndrome: heterozygous Phox2b mutant newborn mice / Jorge Gallego... [et al.] -- 15. Respiratory control abnormalities in necdin-null mice: implications for the pathogenesis of Prader-Willi syndrome / John J. Greer and Rachel Wevrick -- 16. Possible role of bioaminergic systems in the respiratory disorders of Rett syndrome / John Bissonnette and Gerard Hilaire -- 17. Respiratory plasticity following intermittent hypoxia: a guide for novel therapeutic approaches to ventilatory control disorders? / Gordon s Mitchell.
- 2002 MyiLibraryKing, Richard A.; Motulsky, Arno G.; Rotter, Jerome I.
- G protein coupled receptors. Modeling, activation, interactions and virtual screening — Genetic basis of common diseases. 2nd ed. (165)
- Genetic cardiomyopathies : a clinical approach — Geriatric trauma and critical care (165)
- Geriatric urology — Good manufacturing practices for pharmaceuticals. 6th ed. (165)
- Good pharmaceutical manufacturing practice : rationale and compliance — Gynecological imaging : a reference guide to diagnosis (165)
- Harrison's Principles of Internal Medicine
- AAP Red Book Online
- Robbins & Cotran Pathologic Basis of Disease
- Sabiston Textbook of Surgery
- Nelson's Textbook of Pediatrics
- Surgical Exposures in Orthopaedics
- Mandell, Douglas, & Bennett's Principles & Practice of Infectious Diseases
- Red Book Online
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- Primary Care Medicine
- Campbell-Walsh Urology
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