Lane Medical Library

Describes ggplot2, a data visualization package for R and a powerful and flexible system for creating data graphics.

An account of the worst cholera outbreak in Victorian London--and an exploration of how Dr. John Snow's solution revolutionized the way we think about disease in cities. In the summer of 1854, a devastating cholera outbreak seized London just as it was emerging as a modern city: more than 2 million people packed into a ten-mile circumference, a hub of travel and commerce, continually pushing the limits of infrastructure that's outdated as soon as it's updated. Author Johnson chronicles Snow's day-by-day efforts as he risked his own life to prove how the epidemic was being spread. When he created the map that traced the pattern of outbreak back to its source, Dr. Snow didn't just solve a pressing medical riddle--he established a precedent for the way modern city-dwellers, city planners, physicians, and public officials think about the spread of disease and the development of the modern urban environment.--From publisher description.

History to the discovery of ghrelin / Cyril Y. Bowers -- Orphan GPCRs and methods for identifying their ligands / Morikatsu Yoshida, Mikiya Miyazato, and Kenji Kangawa -- Purification of rat and human ghrelins / Masayasu Kojima, Hiroshi Hosoda, and Kenji Kangawa -- Variety of acyl modifications in mammalian ghrelins / Takanori Ida -- Determination of nonmammalian ghrelin / Hiroyuki Kaiya ... [et al.] -- Morphological analysis of ghrelin neurons in the hypothalamus / Haruaki Kageyama, Fumiko Takenoya, and Seiji Shioda -- High-performance liquid chromatography analysis of hypothalamic ghrelin / Takahiro Sato and Masayasu Kojima -- Standard sample collections for blood ghrelin measurements / Hiroshi Hosoda and Kenji Kangawa -- From ghrelin to ghrelin's O-acyl transferase / Jesus A. Gutierrez ... [et al.] -- Enzymatic characterization of GOAT, ghrelin O-acyltransferase / Hideko Ohgusu, Tomoko Takahashi, and Masayasu Kojima -- The study of ghrelin deacylation enzymes / Motoyasu Satou and Hiroyuki Sugimoto -- Synthesis of ghrelin : chemical synthesis and semisynthesis for large-scale preparation of modified peptides / Tomohiro Makino, Masaru Matsumoto, and Yoshiharu Minamitake -- Ghrelin O-acyltransferase assays and inhibition / Martin S. Taylor ... [et al.] -- Model-based evaluation of growth hormone secretion / Johannes D. Veldhuis and Daniel M. Keenan -- Ghrelin in the control of energy, lipid, and glucose metabolism / Kristy M. Heppner ... [et al.] -- Ghrelin and the vagus nerve / Yukari Date -- Measurement of AMP-activated protein kinase activity and expression in response to ghrelin / Chung Thong ... [et al.] -- Ghrelin and gastrointestinal movement / Naoki Fujitsuka ... [et al.] -- Ghrelin acylation by ingestion of medium-chain fatty acids / Yoshihiro Nishi, Hiroharu Mifune, and Masayasu Kojima -- Islet [beta]-cell ghrelin signaling for inhibition of insulin secretion / Katsuya Dezaki and Toshihiko Yada -- Rikkunshito as a ghrelin enhancer / Hiroshi Takeda ... [et al.] -- Thermogenic characterization of ghrelin receptor null mice / Ligen Lin and Yuxiang Sun -- Transgenic mice overexpressing ghrelin or ghrelin analog / Hiroyuki Ariyasu ... [et al.] -- Therapeutic potential of ghrelin in restricting-type anorexia nervosa / Mari Hotta ... [et al.] -- Clinical application of ghrelin for chronic respiratory diseases / Nobuhiro Matsumoto and Masamitsu Nakazato -- Clinical trial of ghrelin synthesis administration for upper GI surgery / Shuji Takiguchi ... [et al.].

Overview of gut immunology / Katie Lynn Mason ... [et al.] -- The commensal microbiology of the gastrointestinal tract / Janet M. Manson, Marcus Rauch and Michael S. Gilmore -- Overview of the gastrointestinal microbiota / -- Vincent B. Young and Thomas M. Schmidt -- Effects of microbiota on GI health : -- Gnotobiotic research / Robert Doug Wagner -- Positive interactions with the microbiota : probiotics / Marko Kalliomøki, Seppo Salminen and Erika Isolauri -- Negative interactions with the microbiota : IBD / Nita H. Salzman and Charles L. Bevins -- Diet, immunity, and functional foods / Lesley Hoyles and Jelena Vulevic -- Host : microbe communication within the GI tract / Christopher A. Allen and Alfredo G. Torres -- Host : microbe symbiosis : the squid, vibrio association : a naturally occurring, experimental model of animal/bacterial partnerships / Margaret McFall-Ngai -- The "microflora hypothesis" of allergic disease / Andrew Shreiner, Gary B. Huffnagle and Mairi C. Noverr -- The damage : response framework of microbial pathogenesis and infectious diseases / Liise-anne Pirofski and Arturo Casadevall.

ch. 1. The Building Blocks of Our World, p. 1-30 -- ch. 2. Small Organic Molecules, p. 31-55 -- ch. 3. Introduction to the Science of Giant Molecules, p. 57-93 -- ch. 4. Relationships Between the Properties and Structure of Giant Molecules, p. 95-112 -- ch. 5. Physical and Chemical Testing of Polymers, p. 113-132 -- ch. 6. Thermoplastics, p. 133-181 -- ch. 7. Engineering Plastics, p. 183-208 -- ch. 8. Thermosets, p. 209-227 -- ch. 9. Fibers, p. 229-250 -- ch. 10. Rubbers (Elastomers, p. 251-274 -- ch. 11. Paints, Coatings, Sealants, and Adhesives, p. 275-291 -- ch. 12. Composites, p. 293-305 -- ch. 13. Nature's Giant Molecules: The Plant Kingdom, p. 307-327 -- ch. 14. Nature's Giant Molecules: The Animal Kingdom, p. 329-363 -- ch. 15. Derivatives of Natural Polymers, p. 365-378 -- ch. 16. Inorganic Polymers, p. 379-403 -- ch. 17. Specialty Polymers, p. 405-423 -- ch. 18. Additives and Starting Materials, p. 425-444 -- ch. 19. The Future of Giant Molecules, p. 445-453 -- Appendix 1. Studying Giant Molecules, p. 455-457 --. Appendix 2. Electronic Web Sites, p. 459-461.

Introduction : the evolving role of geographic information systems in hospital and healthcare emergency management / Ric Skinner -- A spatial approach to hazard vulnerability analysis by healthcare facilities / Ric Skinner -- Using GIS to improve workplace and worker safety crisis management / Jeffrey Miller -- Infectious disease surveillance and GIS : applications for emergency management / Michael Olesen -- Role of GIS in interagency healthcare logistical support during emergencies / Jerry VanVactor -- Design concept for a location-based hazard vulnerability assessment tool for healthcare facilities / Ric Skinner -- Trauma center siting, optimization modeling, and GIS / Charles Branas ... [et al.] -- Healthcare facility disaster planning : using GIS to identify alternate care sites / Johnathon Mohr, J.L. Querry, and Gwenn Allen -- Multi-scale enterprise GIS for healthcare preparedness in South Carolina / Jared Shoultz ... [et al.] --Hospital preparedness planning for evacuation and sheltering with GIS in South Carolina / Jared Shoultz ... [et al.] -- Making sense out of chaos : improving prehospital and disaster response / Elizabeth Walters, Stephen Corbett, and Jeff Grange -- Disaster preparedness for influenza at a community hospital network : a case study / Edward Rafalski ... [et al.] -- Disaster preparedness and response for vulnerable populations : essential role of GIS for emergency medical services during the San Diego County 2007 firestorm / Isabel Corcos... [et al.] -- Natural disasters and the role of GIS in assessing need / Omar Ha-Redeye -- GIS application and a regionalized approach for mass casualty incident planning / Deborah Kim ... [et al.] -- Building a GIS common operating picture for integrated emergency medical services and hospital emergency management response / Frank Zanka.

Should physician-assisted suicide be legalized? /Gerald Dworkin --Slippery slopes and physician-assisted suicide /Neil Levy --Physician-assisted suicide and the medical associations /Dieter Birnbacher --Safe, legal, rare? Physician-assisted suicide and cultural change in the future /Margaret Pabst Battin --Palliative options of last resort: a comparison of voluntarily stopping eating and drinking, terminal sedation, physician-assisted suicide, and voluntary active euthanasia /Timothy E. Quill, Bernard Lo, Dan W. Brock --Physician-assisted suicide in Oregon /Linda Ganzini, Edgar Dahl --Physician-assisted suicide in the Netherlands and Belgium /John Griffiths --Physician-assisted suicide and the German criminal law /Gabriele Wolfslast --Physician-assisted death: an Australian perspective /Alan Rothschild --Assisted dying: the view from the United Kingdom /Sheila A. M. McLean --Physician-assisted suicide: a doctor's perspective /Pieter Admiraal --Physician-assisted suicide in Switzerland: a personal report /Elke M. Baezner-Sailer --TheEuropean convention on human rights protects the right of suicide /Ludwig A. Minelli.

Hirsutism / Steven M. Strong -- Vulvovaginitis / Tracey A. Banks and Michèle G. Curtis -- Sexually transmitted diseases / Lisa M. Hollier -- Chronic pelvic pain / John F. Steege -- Endometriosis / John M. Storment -- Preconception evaluation and counseling / Justin P. Lavin, Jr. and John Stewart, Jr. -- Contraception / Anthony DelConte -- Infertility and recurrent pregnancy loss / John M. Storment -- Surgical and medical abortion / Mitchell D. Creinin -- Urogynecology and pelvic floor dysfunction / Alfred E. Bent -- Lifestyle modification / Jimmy D. Acklin --Integration of complementary and alternative medicine in the gynecology office / Michèle G. Curtis -- Intimate partner violence / Abbey B. Berenson -- Women and sexuality / Gretchen Gross -- Psychiatric disorders / James M. Martinez and Lauren B. Marangell -- Management of the HIV-positive woman / Nancy L. Eriksen -- Diagnosis and management of hereditary cancer / Monique A. Spillman and Andrew Berchuck -- Occupational and environmental exposures / Linda M. Frazier And David A. Grainger.Pediatric and adolescent gynecology / Andrea L. Zuckerman -- Care of perimenopausal and postmenopausal patients / Clarisa R. Gracia and Kurt T. Barnhart -- Lesbian, bisexual, and transgender health care / Amy E. Harrison and Vincent M. B. Silenzio -- Abnormal cytology and human papillomavirus / Barbara M. Buttin, Thomas J. Herzog, and David G. Mutch -- Benign disorders of the vulva and vagina / Wilson Sawa and Michael P. Hopkins -- Benign disorders and diseases of the breast / Daniel P. Guyton and Andrew Fenton -- Premenstrual syndromes / Meir Steiner -- Abnormal uterine bleeding / Godwin I. Meniru and Michael P. Hopkins --

1.Epidemiology of primary glaucoma: prevalence, incidence, and blinding effects --2.Predictive models to estimate the risk of glaucoma development and progression --3.Intraocular pressure and central corneal thickness --4.Angle-closure: risk factors, diagnosis and treatment --5.Early diagnosis of glaucoma --6.Monitoring glaucoma progression --7.Standard automated perimetry and algorithms for monitoring glaucoma progression --8.Short-wavelength automated perimetry and frequency-doubling technology perimetry in glaucoma --9.Scanning laser polarimetry and confocal scanning laser ophthalmoscopy: technical notes on their use in glaucoma --10.The role of OCT in glaucoma management --11.Functional laser Doppler flowmetry of the optic nerve: physiological aspects and clinical applications --12.Advances in neuroimaging of the visual pathways and their use in glaucoma --13.Primary open angle glaucoma: an overview of medical therapy --14.The treatment of normal-tension glaucoma --15.The management of exfoliative glaucoma --16.Laser therapies for glaucoma: new frontiers --17.Modulation of wound healing during and after glaucoma surgery --18.Surgical alternative to trabeculectomy --19Modern aqueous shunt implantation: future challenges --20. Model systems for experimental studies: retinal ganglion cells in culture --21.Rat models for glaucoma research --22.Mouse genetic models: an ideal system for understanding glaucomatous neurodegeneration and neuroprotection --23.Clinical trials in neuroprotection.24.Pathogenesis of ganglion "cell death" in glaucoma and neuroprotection: focus on ganglion cell axonal mitochondria --25.Astrocytes in glaucomatous optic neuropathy --26.Glaucoma as a neuropathy amenable to neuroprotection and immune manipulation --27.Oxidative stress and glaucoma: injury in the anterior segment of the eye --28TNF-alpha signaling in glaucomatous neurodegeneration --29.Involvement of the Bc12 gene family in the signaling and control of retinal ganglion cell death --30.Assessment of neuroprotection in the retina with DARC --31.Potential roles of (endo)cannabinoids in the treatment of glaucoma: from intraocular pressure control to neuroprotection --32.Glaucoma of the brain: a disease model for the study of transsynaptic neural degeneration --33.Changes of central visual receptive fields on experimental glaucoma --34.Targeting excitotoxic/free radical signaling pathways for therapeutic intervention in glaucoma --Stem cells for neuroprotection in glaucoma --36.The relationship between neurotrophic factors and CaMKII in the death and survival of retinal ganglion cells --37.Evidence of the neuroprotective role of citicoline in glaucoma patients --38.Neuroprotection: VEGF, IL-6, and clusterin: the dark side of the moon --39.Rational basis for the development of coenzyme Q10 as a neurotherapeutic agent for retinal protection --40.17Beta-estradiol prevents retinal ganglion cell loss induced by the acute rise of intraocular pressure in rat.

Provides a picture of recent progress in the field of glaucoma.

Glaucoma in the twenty-first century -- An evidence-based approach to glaucoma care -- Glaucoma risk factors: intraocular pressure -- Glaucoma risk factors: fluctuations in intraocular pressure -- Glaucoma is a 24/7 disease -- Continuous monitoring of intraocular pressure -- Aqueous veins and open angle glaucoma -- Glaucoma risk factors: the cornea -- Glaucoma risk factors: family history-the genetics of glaucoma -- Glaucoma risk factors: ethnicity and glaucoma.

Sect. ISurgical techniques --1.Indications, pre-operative evaluation, and outcomes of filtering surgery /Arthur J. Sit and Graham E. Trope --2.Glaucoma: surgical anatomy /Maurice M. Carrillo and Graham E. Trope --3.Modern anesthesia for adult glaucoma filtration surgery /Monica M. Carrillo and Graham E. Trope --4.Advances in modulation of wound healing including large treatment areas and adjustable sutures: the Moorfields safe surgery system /Peng Tee Khaw and Graham E. Trope --5.How to do a trabeculectomy /Clive Migdal and Graham E. Trope --6.Nonpenetrating glaucoma surgery: indications, techniques, and complications /Tarek Shaarawy, Graham E. Trope, and André Mermoud --7.How to insert a glaucoma implant /Jeffrey Freedman and Graham E. Trope --8.Management of glaucoma implant complications /Jeffrey Freedman, Shlomo Melamed, and Graham E. Trope --9.Pars plana insertion of Ahmed glaucoma valve /Roland Ling, Wai-Ching Lam, and Graham E. Trope --10.Full-thickness filtering glaucoma surgery /Maurice H. Luntz and Graham E. Trope --11.How to do a surgical iridectomy /Maurice H. Luntz and Graham E. Trope --12.Combined cataract and glaucoma surgery /Ruth Lapid-Gortzak, David S. Rootman, Yvonne M. Buys, and Graham E. Trope --13.Ultrasound biomicroscopy in glaucoma surgery /Charles J. Pavlin and Graham E. Trope --Sect. IIManagement of complications --14.Overview: an approach to the diagnosis of early postoperative complications /Yvonne M. Buys and Graham E. Trope --A.Management of high intraocular pressure with a deep chamber --15.Massage: techniques and complications /Yvonne M. Buys and Graham E. Trope --16.Glaucoma suture lysis /Graham E. Trope --17.Releasable sutures /Ruth Lapid-Gortzak, David S. Rootman, and Graham E. Trope -- g 18.The failing bleb: risk factors and diagnosis /Paul R. Healey and Graham E. Trope --19.Encapsulated bleb /Adael S. Soares, Marcelo T. Nicolela, Paul E. Rafuse, and Graham E. Trope --20.Needling procedures in postoperative management of glaucoma surgery /Tarek Shaarawy, Peter Gouws, Graham E. Trope, and Andre Mermoud --B.Management of flat anterior chamber with high intraocular pressure --21.Suprachoroidal hemorrhage in filtering surgery and practical management /Ravikrishna Nrusimhadevara, R.G. Devenyi, and Graham E. Trope --22.Malignant glaucoma /Dimitrios Kourkoutas, Charlie J. Pavlin, and Graham E. Trope --C.Management of a flat chamber with low intraocular pressure --23.Management of the leaking bleb /Andrew C. Crichton, Garry P. Condon, and Graham E. Trope --24.Remodeling the filtration bleb /J.E. Morgan and Graham E. Trope --25.Management of flat anterior chambers and choroidal effusions /Ridia Lim, Ivan Goldberg, and Graham E. Trope --26.Hypotony maculopathy /Catherine M. Birt and Graham E. Trope --D.Management of bleb infection --27.Blebitis and bleb-associated endophthalmitis: diagnosis and treatment /Fani Segev, Allan R. Slomovic, and Graham E. Trope --Index.

Anatomy of the adrenal glands, kidney, ureter, and pelvis -- Partial nephrectomy -- Radical nephrectomy -- Intracaval tumors -- Transplant nephrectomy -- Renovascular disease -- Anatrophic nephrolithotomy -- Renal and retroperitoneal abscesses -- Renal trauma -- Renal allotransplantation -- Ureteral complications following renal transplantation -- Renal autotransplantation -- Anatomy of the bladder -- Simple and partial cystectomy -- Radical cystectomy in men -- Radical cystectomy in women -- Bladder diverticulectomy -- Bladder augmentation -- Management of the distal ureter for nephrourecterectomy -- Vesicovaginal fistula -- Enterovesical and rectourethral fistulas -- Vesical trauma and hemorrhage -- Interstitial cystitis/painful bladder syndrome -- Anatomy of the prostate -- Surgery for benign prostatic hypertrophy -- Prostatic imaging and biopsy -- Pelvic lymphadenectomy -- Open radical retropubic prostatectomy -- Radical perineal prostatectomy -- Brachytherapy for localized prostate cancer -- Anatomy of the urethra -- Female urethral diverticulum -- Reconstruction of the female urethra -- Surgical management of the incompetent bladder outlet in the patient with a neurogenic bladder -- Surgery for urethral stricture disease -- Surgery for urethral trauma including urethral disruption -- Carcinoma of the female urethra -- Carcinoma of the male urethra -- Injectable therapies for incontinence in women -- Pubovaginal fascial slings -- Synthetic midurethral retropubic slings -- The transobturator approach to the midurethral sling -- Abdominal retropubic approaches for female incontinence -- The artificial urinary sphincter -- The male sling for postprostatectomy incontinence: current concepts and controversies -- Sacral neuromodulation -- Surgical treatment of pelvic organ prolapse: anatomy of the pelvic floor -- Vaginal hysterectomy for uterine prolapse -- Cystocele and anterior vaginal prolapse -- Transvaginal repair of apical prolapse -- Posterior vaginal prolapse repair -- Abdominal sacral colpopexy -- Anatomy of the epididymis, vas deferens, and seminal vesicle -- Seminal vesicle and ejaculatory duct surgery -- Vasectomy.; Vasoepididymostomy -- Vasovasostomy -- Microsurgical varicocelectomy -- Testis biopsy and testicular sperm extraction (TESE) -- Epididymal sperm aspiration -- Epididymectomy -- Ejaculation induction procedures: penile vibratory stimulation and electroejaculation -- Anatomy of the testis -- Simple orchiectomy -- Inguinal orchiectomy -- Organ-preserving surgery in testicular tumors -- Retroperitoneal lymphadenectomy -- Torsion of the testicle -- Scrotal trauma and reconstruction -- Anatomy of the penis and scrotum -- Partial and total penectomy in the management of invasive squamous cell carcinoma of the penis -- Inguinal lymphadenectomy for penile carcinoma -- Surgical treatment of Peyronie disease -- Priapism -- Penile prosthesis implantation -- Penile venous surgery -- Microvascular arterial bypass surgery for erectile dysfunction -- Penile trauma -- Penile replantation -- Varicocele: general considerations -- Hydrocele and spermatocele -- Congenital curvature -- Reconstruction of the penis for complications of penile enhancement surgery --Ileal conduit urinary diversion -- Transverse colonic conduit -- Managing the with patient orthotopic bladder substitution -- Orthotopic urinary diversion using in ileal low-pressure reservoir with an afferent tubular segment -- Ileal neobladder -- The Padua ileal bladder -- The T-pouch ileal neobladder -- Colonic orthotopic bladder substitution -- Continent catheterizable reservoir made from ileum -- Continent catheterizable reservoir made from colon -- Ureterosigmoidostomy: Mainz pouch II -- Palliative urinary diversion -- Neuroblastoma -- Wilms tumor -- Renal fusion and ectopia -- Transureteroureterostomy -- Pyeloplasty -- Megaureter -- Prune belly (triad) syndrome -- Childhood rhabdomyosarcoma -- Vesicoureteral reflux -- Endoscopic treatment of vesicoureteral reflux -- Ureteroceles -- Urachal anomalies and related umbilical disorders -- Vesical neck reconstruction -- Surgery for posterior urethral valves -- Hypospadias -- Complete primary repair for exstrophy -- Bladder exstrophy and epispadias -- Congenital anomalies of the scrotum -- Pediatric cryptorchidism, hydroceles, and hernias -- Laparoscopic management of the undescended testicle -- Pediatric laparoscopic pyeloplasty -- Pediatric laparoscopic nephrectomy and partial nephrectomy.; Urogenital sinus and cloacal anomalies -- Surgery to correct ambiguous genitalia (46XX disorder of sexual development) -- Circumcision -- Augmentation cystoplasty in children -- The mitrofanoff procedure in pediatric urinary tract reconstruction -- Basic principles of laparoscopy: transperitoneal, extraperitoneal, and hand-assisted techniques -- Laparoscopic pelvic and retroperitoneal lymph node dissection -- Laparoscopic nephrectomy and partial nephrectomy -- Laparoscopic nephroureterectomy -- Laparoscopic renal procedures: renal cystectomy, biopsy, and nephropexy -- Laparoscopic ablation of small renal masses -- Donor nephrectomy: laparoscopic techniques -- Laparoscopic and robotically assisted pyeloplasty in adults -- Laparoscopic adrenalectomy -- Laparoscopic and robotic radical prostatectomy -- Laparoscopic management of lymphoceles -- Laparoscopic bladder procedures: radical cystectomy, partial cystectomy, urachal excision, diverticulectomy -- Laparoscopic bladder neck suspension -- Miscellaneous laparoscopic urologic procedures: calculus, varicocele, ureterolysis -- Tissue-engineering strategies for urogenital repair -- Image-guided therapy: current practice and future directions -- Robotic surgery -- Energy sources in urology.

Molecular biology of glioma / Tomotoshi Marumoto and Hideyuki Saya -- Recent surgical management of gliomas / Nader Sanai and Mitchel S. Berger -- Recent medical management of glioblastoma / Derek R. Johnson and Susan M. Chang -- Basic concepts in glioma immunology / Ian F. Parney -- Mechanisms of immune evasion by gliomas / Cleo E. Rolle, Sadhak Sengupta, and Maciej S. Lesniak -- Glioma antigen / Masahiro Toda -- Cytokine therapy / Masasuke Ohno, Atsushi Natsume, and Toshihiko Wakabayashi -- Immunotherapeutic approach with oligodeoxynucleotides containing CpG motifs (CpG ODN) in malignant glioma / Renata Ursu and Antoine F. Carpentier -- Adoptive cell transfer therapy for malignant gliomas / Eiichi Ishikawa ... [et al.] -- Monoclonal antibody therapy for malignant glioma / Kevin S. Chen and Duane A. Mitchell -- Animal models for vaccine therapy / Dong-Sup Chung, Chang-Hyun Kim, and Yong-Kil Hong -- Immunogene therapy / Terry Lichtor and Roberta P. Glick -- Peptide vaccine / Shuichi Izumoto -- Active immunotherapy : oncolytic virus therapy using HSV-1 / Tomoki Todo -- Dendritic cell vaccines / Ryuya Yamanaka and Koji Kajiwara -- Antigen-receptor gene-modified T cells for treatment of glioma / Hiroaki Ikeda and Hiroshi Shiku -- Glioma stem cell research for the development of immunotherapy / Qijin Xu, Xiangpeng Yuan, and John S. Yu.

Part I. Gliomas -- Astrocytic tumors / Markus J. Riemenschneider and Guido Reifenberger -- Molecular pathology of oligodendroglial tumors / Christian Hartmann and Andreas von Deimling -- Ependymal tumors / Martin Hasselblatt -- Pediatric gliomas / Stefan Pfister and Olaf Witt -- Hereditary tumor syndromes and gliomas / David Reuss and Andreas von Deimling -- Part II. Management of gliomas -- Surgical management of intracranial gliomas / Matthias Simon and Johannes Schramm -- Radiation therapy / Stephanie E. Combs -- Adjuvant therapy / Wolfgang Wick and Michael Weller -- Other experimental therapies for glioma / Manfred Westphal and Katrin Lamszus -- Neurotoxicity of treatment / Pasquale Calabrese and Uwe Schlegel -- Neuroimaging / R. Klingebiel and G. Bohner -- Part III. Angiogenesis in gliomas / Marcia Machein and Lourdes Sánchez de Miguel -- Gene regulation by methylation / Wolf C. Mueller and Andreas von Deimling -- Brain tumor stem cells / Christian Nern, Daniel Sommerlad, Till Acker and Karl H. Plate.

Acknowledgements -- Introduction: about this Guide -- Part 1. Global ageing and urbanization: meeting the challenge of humanity's success -- Part 2. Active ageing: a framework for age-friendly cities -- Part 3. How the Guide was developed -- Part 4. How to use the Guide -- Part 5. Outdoor spaces and buildings -- Part 6. Transportation -- Part 7. Housing -- Part 8. Social Participation -- Part 9. Respect and social inclusion -- Part 10. Civic participation and employment -- Part 11. Communiciation and information -- Part 12. Community support and health services -- Part 13. Wrapping up and moving forward -- References.

"This fourth volume of the Global Burden of Disease and Injuries Series provides the reader with information on the epidemiology and burden of major infectious and parasitic diseases. As with previous volumes of the Global Burden of Disease study, the chapters in this book detail the situation as experienced in the year 1990. Since then the epidemiology of some of the conditions described has changed, and where this is the case the authors have added a brief paragraph acknowledging this. The chapters therefore do not provide a detailed update on the current burden of disease, which is accommodated in the documentation of the Global Burden of Disease 2000 and published elsewhere."--Preface.

Know your enemy -- The Murky past of influenza -- Misidentifications and false starts -- The 1920s to the 1980s -- Renewed fears of flu -- Yet another surprise.

The Global Library of Women's Medicine is a unique web library incorporating a vast range of detailed clinical information across women's medicine. It consists of 442 main chapters and 53 supplementary chapters, supported by over 40,000 references, which will be kept permanently up-to-date. The chapters have been written by more than 650 specialists and will reflect some of the very best worldwide opinion.

Chapter 1. Pediatric Obesity: A Pediatrician's Viewpoint / Allison Collins, Rebecka Peebles -- Chapter 2. Salient Features on Child Obesity from the Viewpoint of a Nutritionist / Bernard Waysfeld, Dominique Adele Cassuto -- Chapter 3. Developmental Trajectories of Weight Status in Childhood and Adolescence / Samar Hejazi, V. Susan Dahinten, Pamela A. Ratner, Sheila K. Marshall -- Chapter 4. The Measurement and Epidemiology of Child Obesity / David S. Freedman, Cynthia L. Ogden, Sarah E. Cusick -- Chapter 5. Good-Enough Parenting, Self-Regulation, and the Management of Weight-Related Problems / Moria Golan -- Chapter 6. Nursing Perspective on Childhood Obesity / Cynthia Yensel, Carrie Tolman -- Chapter 7. Contemporary Racial/Ethnic and Socioeconomic Patterns in U.S. Childhood Obesity / Gopal K. Singh, Michael D. Kogan -- Chapter 8. Prediabetes among Obese Youth / Orit Pinhas-Hamiel, Phil Zeitler -- Chapter 9. Prediabetes and Type 2 Diabetes: An Emerging Epidemic among Obese Youth / Kathryn Love-Osborne -- Chapter 10. Prevalence of the Metabolic Syndrome in U.S. Youth / Sarah E. Messiah, Kristopher L. Arheart, Steven E. Lipshultz, Tracie L. Miller -- Chapter 11. Emerging Pathways to Child Obesity Starts from the Mother's Womb: A Prospective View / Ashik Mosaddik -- Chapter 12. The Social, Cultural and Familial Contexts Contributing to Childhood Obesity / Cathy Banwell, Helen Kinmonth, Jane Dixon -- Chapter 13. Cardiovascular Risk Clustering in Obese Children / Ram Weiss -- Chapter 14. A Link between Maternal and Childhood Obesity / Siân Robinson -- Chapter 15. Is Prenatal Exposure to Maternal Obesity Linked to Child Mental Health? / Alina Rodriguez -- Chapter 16. Sleep and Obesity in Children and Adolescents / Amy Darukhanavala, Silvana Pannain -- Chapter 17. Cellular Remodeling during the Growth of the Adipose Tissue / Coralie Sengenès, Virginie Bourlier, Jean Galitzky, Alexia Zakaroff-Girard, Max Lafontan, Anne Bouloumié -- Chapter 18. Children Obesity, Glucose Tolerance, Ghrelin, and Prader-Willi Syndrome / Simonetta Bellone, Arianna Busti, Sara Belcastro, Gianluca Aimaretti, Gianni Bona, Flavia Prodam -- Chapter 19. Insulin Resistance and Glucose Metabolism in Childhood Obesity / Subhashini Yaturu, Sushil K. Jain -- Chapter 20. Insulin Resistance in Pediatric Obesity: Physiological Effects and Possible Diet Treatment / Ulf Holmbäck -- Chapter 21. Role of Fatty Liver Disease in Childhood Obesity / Valerio Nobili, Anna Alisi, Melania Manco -- Chapter 22. An Overview of Psychosocial Symptoms in Obese Children / Lisa Y. Gibson --Chapter 23. Childhood Obesity: Depression, Anxiety and Recommended Therapeutic Strategies / Dana L. Rofey, Jessica J. Black, Jennifer E. Phillips, Ronette Blake, KayLoni Olson -- Chapter 24. The Emotional Impact of Obesity on Children / Robert E. Cornette -- Chapter 25. Psychiatric Illness, Psychotropic Medication, and Childhood Obesity / Lawrence Maayan, Leslie Citrome -- Chapter 26. Childhood Obesity: Public Health Impact and Policy Responses / Rogan Kersh, Brian Elbel -- Chapter 27. Childhood Obesity and Juvenile Diabetes / Mikael Knip -- Chapter 28. Bone Health in Obesity and the Cross Talk between Fat and Bone / Sowmya Krishnan, Venkataraman Kalyanaraman -- Chapter 29. A Community-Level Perspective for Childhood Obesity Prevention / Christina Economos, Erin Hennessy -- Chapter 30. School-Based Obesity-Prevention Programs / Genevieve Fridlund Dunton, Casey P. Durand, Nathaniel R. Riggs, Mary Ann Pentz -- Chapter 31. School-Based Obesity Prevention Interventions Show Promising Improvements in the Health and Academic Achievements among Ethnically Diverse Young Children / Danielle Hollar, Sarah E. Messiah, Gabriela Lopez-Mitnik, T. Lucas Hollar, Michelle Lombardo -- Chapter 32. School and Community-Based Physical Education and Healthy Active Living Programs: Holistic Practices in Hong Kong, Singapore, and the United States / Ming-Kai Chin, Christopher R. Edginton, Mei-Sin Tang, Kia-Wang Phua, Jing-Zhen Yang -- Chapter 33. Schools as “Laboratories” for Obesity Prevention: Proven Effective Models / Michelle Lombardo, Danielle Hollar, T. Lucas Hollar, Karen McNamara -- Chapter 34. Fitness and Fatness in Childhood Obesity: Implications for Physical Activity / Sarah P. Shultz, Benedicte Deforche, Nuala M. Byrne, Andrew P. Hills -- Chapter 35. Pharmacotherapy in Childhood Obesity / Amélio F. Godoy-Matos, Erika Paniago Guedes, Luciana Lopes de Souza, Mariana Farage -- Chapter 36. Beverage Interventions to Prevent Child Obesity / Rebecca Muckelbauer, Mathilde Kersting, Jacqueline Müller-Nordhorn -- Chapter 37. Psychotherapy as an Intervention for Child Obesity / Carl-Erik Flodmark -- Chapter 38. Childhood Obesity: Psychological Correlates and Recommended Therapeutic Strategies / Jennifer E. Phillips, Ethan E. Hull, Dana L. Rofey -- Chapter 39. Dietary Supplements in the Prevention and Treatment of Childhood Obesity / Robert I-San Lin -- Chapter 40. The Role of Arginine for Treating Obese Youth / Catherine J. McNeal, Guoyao Wu, Susie Vasquez, Don P. Wilson, M. Carey Satterfield, Jason R. McKnight, Hussain S. Malbari, Mujtaba Rahman -- Chapter 41. Prevention of Childhood Obesity with Use of Natural Products / Jin-Taek Hwang, Dae Young Kwon, Joohun Ha -- Chapter 42. The Role of United States Law to Prevent and Control Childhood Obesity / Jennifer L. Pomeranz -- Chapter 43. Childhood Obesity as an Amplifier of Societal Inequality in the United States / Stanley J. Ulijaszek -- Chapter 44. Childhood Obesity, Food Choice and Market Influence / Jane Kolodinsky, Amanda Goldstein, Erin Roche -- Chapter 45. The Role of Media in Childhood Obesity / Amy B. Jordan, Ariel Chernin -- Chapter 46. Evaluation and Management of Childhood Obesity in Primary Care Settings / Goutham Rao -- Chapter 47. The Future Directions and Clinical Management of Childhood Obesity / Clodagh S. O'Gorman, Jonathan Cauchi, Jill K. Hamilton, Denis Daneman.

Global perspectives on health promotion and effectiveness: an introduction / David V. McQueen and Catherine M. Jones -- The Global Programme on Health Promotion Effectiveness (GPHPE): a global process for assessing health promotion effectiveness with regional diversity / Catherine M. Jones ... [et al.] -- The IUHPE blueprint for direct and sustained dialogue in partnership initiatives / Catherine M. Jones and Maurice B. Mittelmark -- The Global Programme on Health Promotion Effectiveness: a case study of global partnership functioning / J. Hope Corbin and Maurice B. Mittelmark -- Policies for health: the effectiveness of their development, adoption, and implementation / Evelyne de Leeuw -- Strengthening the evidence base for mental health promotion / Margaret M. Barry ... [et al.] -- Effectiveness and challenges for promoting physical activity globally / Trevor Shilton ... [et al.] -- School health promotion: achievements, challenges, and priorities / Lawrence St. Leger ... [et al.] -- Health promotion to prevent obesity: evidence and policy needs / Tim Lobstein and Boyd Swinburn -- Effective health promotion against tobacco use / Karen Slama ... [et al.] -- Effectiveness of health promotion in preventing alcohol related harm / Peter Howat ... [et al.] --Globalization and health promotion: the evidence challenge / Ronald Labonte -- Urbanization and health promotion: challenges and opportunities / Andrea Neiman and Mary Hall -- Community interventions on social determinants of health: focusing the evidence / Marilyn Metzler ... [et al.] -- Strengthening peace-building through health promotion: development of a framework / Anne W. Bunde-Birouste and Jan E. Ritchie -- The role of governance in health promotion effectiveness / Marilyn Wise -- Evidence and theory: continuing debates on evidence and effectiveness / David V. McQueen -- Measurement and effectiveness: methodological considerations, issues, and possible solutions / Stefano Campostrini -- Healthy settings: building evidence for the effectiveness of whole system health promotion--challenges and future directions / Mark Dooris ... [et al.] -- Feasibility for health promotion under various decision-making contexts / Ligia de Salazar -- Evaluating equity in health promotion / Louise Potvin, Pascale Mantoura, and Valéry Ridde -- Evaluation of empowerment and effectiveness: universal concepts? / Valéry Ridde, Treena Delormier, and Ghislaine Goudreau -- Enhancing the effectiveness and quality of health promotion: perspectives of the International Union for Health Promotion and Education / Maurice B. Mittelmark ... [et al.] -- Annex: Global Programme on Health Promotion Effectiveness: description and list of partners.

Navigating the GPIRM -- Acronyms and abbreviations -- Contributors -- Foreword -- Executive summary -- Part 1. The threat of insecticide resistance -- 1.1 Malaria vector control today -- 1.2 Status of insecticide resistance -- 1.3 Potential effect of resistance on the burden of malaria -- 1.4 Available strategies for managing resistance -- Part 2. Collective strategy against insecticide resistance -- 2.1 Overall malaria community strategy -- 2.2 Country activities -- 2.3 Research agenda -- 2.4 enabling mechanisms -- 2.5 Financial cost -- Part 3. Technical recommendations for countries -- 3.1 Geographical areas with unknown levels of resistance -- 3.2 Geographical areas in which indoor residual spraying is the main form of vector control -- 3.3 Geographical areas in which LLINs are the main form of vector control -- 3.4 Geographical areas in which LLINs and IRs are already used in combination -- 3.5 Choosing alternative insecticides -- Part 4. Near-term action plan -- 4.1 Role of each stakeholder group -- 4.2 Action plan -- References -- Annex 1 Past use of malaria vector control tools -- Annex 2 Long-lasting insecticidal nets, indoor residual spraying and other vector control interventions -- Annex 3 History of insecticide resistance in malaria vectors -- Annex 4 Challenges in measuring the impact of insecticide resistance on the effectiveness of vector control -- Annex 5 example of 'tipping-point' in resistant Aedes mosquitoes -- Annex 6 selection pressure: role of public health, agriculture and other factors -- Annex 7 Implications of discriminating doses of insecticide on detection of resistance -- Annex 8 Main hypotheses used to model the impact of insecticide resistance on malaria burden -- Annex 9 use of insecticide resistance management strategies (rotations, combinations, mosaics and mixtures) -- Annex 10 Genetic research agenda -- Annex 11 Financial modelling -- Annex 12 Definitions.

Key Terms in Palliative Care and Pain Treatment -- Summary -- I. Background: Palliative Care and Pain Treatment -- The Need for Palliative Care and Pain Treatment -- The Consequences of Untreated Pain and Lack of Palliative Care -- Impact of Palliative Care and Pain Management -- The Palliative Care and Pain Treatment Gap -- Barriers to Palliative Care and Pain Treatment -- II. Survey Findings: Global Overview of Barriers to Pain Treatment -- Availability of Policies that Promote Palliative Care and Pain Treatment -- Training for Healthcare Workers -- Drug Availability -- Supply and Distribution System for Opioid Analgesics -- Drug Regulations -- Cost of Opioid Medications -- Best Practices: Addressing Barriers to Pain Treatment and Palliative Care through Comprehensive Reform -- Africa Map -- III. Sub-Saharan Africa -- Regional Overview -- Drug Availability -- Drug Regulations -- Best Practice and Reform Efforts: Uganda -- The Americas Map -- IV. The Americas -- Regional Overview -- Drug Availability -- Best Practice and Reform Efforts: Colombia -- The Middle East and North Africa Map -- V. The Middle East and North Africa -- Regional Overview -- Drug Availability -- Developing Palliative Care: Jordan -- Europe Map -- VI. Europe -- Regional Overview -- Drug Availability -- Best Practice and Reform Efforts: Romania -- Asia Map -- VII. Asia -- Regional Overview -- Drug Availability -- Developing Palliative Care: Vietnam -- VIII. International Human Rights Obligations and Pain Treatment -- Health as a Human Right -- Pain Treatment and the Right to the Highest Attainable Standard of Health -- Pain Treatment and the Right to Be Free from Cruel, Inhuman, and Degrading Treatment -- IX. Recommendations -- To Governments around the World -- General -- Ensuring an Effective Supply System -- Developing and Enacting Pain Management and Palliative Care Policies -- Ensuring Instruction for Healthcare Workers -- Reforming Drug Regulations -- Ensuring Affordability of Medications -- To Global Drug Policy Makers -- To the WHA, WHO, UNAIDS, and the Donor Community -- To the Global Human Rights Community -- X. Methodology -- Acknowledgements -- Appendix 1. List of Survey Participants -- Appendix 2. Survey Questions -- Appendix 3. Table of Calculations Used to Produce Maps.

"This publication presents a comprehensive perspective on the worldwide, regional and country consumption of alcohol, patterns of drinking, health consequences and policy responses in member states. It represents a continuing effort by WHO to support member states with global information in their efforts to reduce the harmful use of alcohol and its health and social consequences"--Publisher's description.

"This report sets out the statistics, evidence and experiences needed to launch a more forceful response to the growing threat posed by noncommunicable diseases. While advice and recommendations are universally relevant, the report gives particular attention to conditions in low- and middle-income countries, which now bear nearly 80% of the burden from diseases like cardiovascular disease, diabetes, cancer and chronic respiratory diseases. The health consequences of the worldwide epidemic of obesity are also addressed. The report takes an analytical approach, using global, regional and country-specific data to document the magnitude of the problem, project future trends, and assess the factors contributing to these trends. As noted, the epidemic of these diseases is being driven by forces now touching every region of the world: demographic aging, rapid unplanned urbanization, and the globalization of unhealthy lifestyles"--Publisher's description.

"Over 1.2 million people die each year on the world' roads, and between 20 and 50 million suffer non-fatal injuries. In most regions of the world this epidemic of road traffic injuries is still increasing. In the past five years most countries have endorsed the recommendations of the World report on road traffic injury prevention which give guidance on how countries can implement a comprehensive approach to improving road safety and reducing the death toll on their roads. To date, however, there has been no global assessment of road safety that indicates the extent to which this approach is being implemented. This Global status report on road safety is the first broad assessment of the status of road safety in 178 countries, using data drawn from a standardized survey conducted in 2008. The results provide a benchmark that countries can use to assess their road safety position relative to other countries, while internationally the data presented can collectively be considered as a global "aseline"against which progress over time can be measured. " - p. [v11]

Pt. I. General concepts. 1. Glutamate receptors in peripheral tissues: distribution and implications for toxicology / Santokh Gill and Olga Pulido -- 2. Glutamate receptor pharmacology: lessons learned from the last decade of stroke trials / Daniel L. Small and Joseph S. Tauskela -- 3. Expression of non-organelle glutamate transporters to support peripheral tissue function / James C. Matthews -- 4. Anticancer effects of glutamate antagonists / Wojciech Rzeski, Lechoslaw Turski, and Chrysanthy Ikonomidou -- 5. Glutamate receptors and their role in acute and inflammatory pain / Susan M. Carlton -- Pt. II. Specific target tissues, organs, and systems. 6. The vertebrate retina / Victoria P. Connaughton -- 7. Glutamate receptors in taste receptor cells / Albertino Bigiani -- 8. Glutamate recepts in endocrine tissues / Tania F. Gendron and Paul Morley --9. Adrenal glutamate receptors: a role in stress and drug addiction? / Daniela Jezova and Marek Schwendt -- 10. Glutamate receptors in the stomach and their implications / Li Hsueh Tsai and Jang-yen Wu -- 11. Glutamate toxicity in lung and airway disease / Sami I. Said -- 12. Glutamate: teaching old bones new tricks - implications for skeletal biology / Gary J. Spencer, Ian S. Hitchcock, and Paul G. Genever -- 13. Expression and function of metabotrophic glutamate receptors in liver / Marianna Storto ... [et al.] -- 14. Neuroexcitatory signaling in immune tissues / Helga S. Haas and Konrad Schauenstein -- 15. Platelet glutamate receptors as a window into psychiatric disorders / Michael Berk -- Pt. III. Non-mammalian organisms. 16. Analysis of glutamate receptor genes in plants: progress and prospects / Joanna C. Chiu ... [et al.].

N-Methyl-d-Aspartate (NMDA) Antagonists for the Treatment of Depression / Phil Skolnick, Piotr Popik and Ramon Trullas -- Ionic Glutamate Modulators in Depression (Zinc, Magnesium) / Bernadeta Szewczyk, Ewa Poleszak, Andrzej Pilc and Gabriel Nowak -- Positive Allosteric Modulation of AMPA Receptors: A Novel Potential Antidepressant Therapy / Eric S. Nisenbaum and Jeffrey M. Witkin -- Glutamatergic Modulators for the Treatment of Major Depressive Disorder: Metabotropic Glutamate Receptors / Jeffrey M. Witkin -- Positive Modulation of AMPA Receptors as a Broad-Spectrum Strategy for Treating Neuropsychiatric Disorders / Gary Lynch, Julie C. Lauterborn and Christine M. Gall -- Activation of Group II Metabotropic Glutamate Receptors (mGluR2 and mGluR3) as a Novel Approach for Treatment of Schizophrenia / Douglas J. Sheffler and P. Jeffrey Conn -- mGluR1 Negative Allosteric Modulators: An Alternative Metabotropic Approach for the Treatment of Schizophrenia / Hisashi Ohta, Hiroshi Kawamoto and Gentaroh Suzuki -- Metabotropic Glutamate Receptors as Targets for the Treatment of Drug and Alcohol Dependence / Svetlana Semenova and Athina Markou -- Metabotropic Approaches to Anxiety / Joanna M. Wieronska, Gabriel Nowak and Andrzej Pilc.

Heparan sulfate proteoglycan in inflammation and angiogenesis / Lianchun Wang -- Heparan sulfate proteoglycans in infection / Allison H. Bartlett and Pyong Woo Park -- Glycans in cancer / Lubor Borsig -- Glycosaminoglycans in atherosclerosis and thrombosis / C.P. Vicente, J.A.P. Godoy, and C.C. Werneck -- Glycans in embryonic stem cells / Claire Pickford ... [et al.] -- Heparan sulfate proteoglycans in cancer therapy / Ezeddin Salem Gassar, Sherif A. Ibrahim, and Martin Götte -- Structure and biological activities of glycosaminoglycan analogs from marine invertebrates : new therapeutic agents? / Eliene O. Kozlowski ... [et al.]

Gene expression analysis of glycosylation-related genes by real-time polymerase chain reaction / Juan J. Garcia-Vallejo ... [et al.] -- Analysis of the glycodynamics of primary osteoblasts and bone cancer cells / Inka Brockhausen-Schutzbach, Xiaojing Yang, and Mark Harrison -- Micromethods for the characterization of lipid a core and o-antigen lipopolysaccharide / Cristina L. Marolda ... [et al.] -- Assays for a galactosyltransferase involved in the assembly of the O7 antigen repeat unit of escherichia coli / Inka Brockhausen-Schutzbach ... [et al.] -- High-throughput quantitation of metabolically labeled anionic glycoconjugates by scintillation proximity assay utilizing binding to cationic dyes / Karen J. Rees-Milton and Tassos P. Anastassiades -- Quantitative analysis of mucins in mucosal secretions using indirect ELISA / Pablo Argueso and Ilene K. Gipson -- Molecular dissection of the mouse zona pellucida: an electron microscopic perspective utilizing high-resolution colloidal-gold labeling methods / Frederick W. K. Kan -- Soluble adamantly glycosphingolipid analogs as probes of glycosphingolipid function / Clifford Lingwood ... [et al.] -- Diagnosis of Krabbe disease by use of a natural substrate / John W. Callahan and Marie-Anne Skomorowski -- In vitro assays of the functions of calnexin and calreticulin, lectin-chaperones of the endoplasmic reticulum / Breanna S. Ireland, Monika Niggemann, and David B. Williams -- Quantitative measurement of selectin-ligand interactions: assays to identify a sweet pill in a library of carbohydrates / Mark E. Beauharnois, Sriram Neelamegham, and Khushi L. Matta -- Sialic acid-binding specificities of siglecs / Nadine Bock and Soerge Kelm.The application of fluorophore-assisted carbohydrate -- Electrophoresis for the study of the dolichol pyrophosphate-linked oligosaccharides pathway in cell cultures and animal tissues / Ningguo Gao -- Partial purification of mannosylphosphorylundecaprenol synthase from micrococcus luteus: a useful enzyme for the biosynthesis of a variety of mannosylphosphorylpolyisoprenol products / Jeffrey S. Rush and Charles J. Waechter -- Assay of dolichyl-phospho-mannose synthase reconstituted in a lipid matrix / John S. Schutzbach -- O-mannosylation in mammalian cells / Tamao Endo and Hiroshi Manya -- Methods for analysis of unusual forms of o-glycosylation / Aleksandra Nita-Lazar and Robert S. Haltiwanger -- Structural analysis of naturally occurring sialic acids / Johannis P. Kamerling and Gerrit J. Gerwig -- Non-radioactive trans-sialidase screening assay / Silke Schrader and Roland Schauer -- Structural determination of o-glycans by tandem mass spectrometry / Catherine Robbe, Jean-Claude Michalski, and Calliope Capon -- Detailed structural analysis of n-glycans released from glycoproteins in SDS-page gel bands using HPLC combined with exoglycosidase array digestions / Louise Royle ... [et al.] -- Molecular modeling of glycosyltransferases / Anne Imberty ... [et al.] -- Galactoside_2,6-sialyltransferase (st6gal.i) and the sialyl_2,6-galactosyl-linkage in tissues and cell lines / Fabio Dall'Olio, Nadia Malagolini, and Mariella Chiricolo -- Visualizing intracellular distribution and activity of core 2 _(1,6)n-acetylglucosaminyltransferase-I (C2GNT-I) in living cells / Maelle Prorok-Hamon, Sylvie Mathieu, and Assou El-Battari --

Analysis of N- and O-linked glycans from glycoproteins using MALTI-TOF mass spectrometry / Willy Morelle ... [et al.] -- Infrared multiphoton dissociation mass spectrometry for structural elucidation of oligosaccharides / Bensheng Li ... [et al.] -- Mass spectrometry of N-linked glycans / Parastoo Azadi and Christian Heiss -- Solid-phase permethylation for glycomic analysis / Yehia Mechref, Pilsoo Kang, and Milos V. Novotny -- Method for investigation of oligosaccharides using phenylhydrazine derivatization / Erika Lattová and Hélène Perreault -- Two-dimensional HPLC separation with reverse-phase-nano-LC-MS/MS for the characterization of glycan pools after labeling with 2-aminobenzamide / Manfred Wuhrer, Carolien A.M. Koeleman, and André M. Deelder -- Capillary lectin-affinity electrophoresis for glycan analysis / Kazuaki Kakehi and Mitsuhiro Kinoshita -- Analysis of methylated O-glycan alditols by reversed-phase nanoLC coupled CAD-ESI mass spectrometry / Franz-Georg Hanisch and Stefan Müller -- High-throughput and high-sensitivity nano-LC/MS and MS/MS for O-glycan profiling / Hasse Karlsson ... [et al.] -- Collision-induced dissociation tandem mass spectrometry for structural elucidation of glycans / Bensheng Li ... [et al.] -- The structural elucidation of glycosaminoglycans / Vikas Prabhakar, Ishan Capila, and Ram Sasisekharan -- Labelling heparan sulphate saccharides with chromophore fluorescence and mass tags for HLC and MS separations / Mark Skidmore ... [et al.] -- Small-scale enzymatic digestion of glycoproteins and proteoglycans for analysis of oligosaccharides by LC-MS and FACE gel electrophoresis / Ruby P. Estrella ... [et al.] -- Enrichment strategies for glycopeptides / Shigeyasu Ito, Ko Hayama, and Jun Hirabayashi -- Introductory glycosylation analysis using SDS-PAGE and peptide mass fingerprinting / Nicole Wilson, Raina Simpson, and Catherine Cooper-Liddell -- Characterization of N-linked glycosylation on recombinant glycoproteins produced in Pichia pastoris using ESI-MS and MALDI-TOF / Bing Gong ... [et al.] -- N-glycosylation site analysis of human platelet proteins by hydrazide affinity capturing and LC-MS/MS / Urs Lewandrowski and Albert Sickmann -- LC/MSn for glycoprotein analysis : N-linked glycosylation analysis and peptide sequencing of glycopeptides / Nana Kawasaki, Satsuki Itoh, and Teruhide Yamaguchi -- Detecting the "O-GlcNAcome" : detection, purification, and analysis of O-GlcNAc modified proteins / Natasha E. Zachara -- Preparation of a glycan library using a variety of glycosyltrasferases [i.e. glycosyltransferases] / Hiromi Ito ... [et al.] -- Data mining the PDB for glyco-related data / Thomas Lütteke and Claus-W. von der Lieth -- Saccharide microarrays for high-throughput interrogation of glycan-protein binding interactions / Andrew K. Powell, Zheng-liang Zhi, and Jeremy E. Turnbull -- Glocosaminoglycan characterization methodologies probing biomolecular interactions / Vikas Prabhakar, Ishan Capila, and Ram Sasisekharan -- Development and characterization of antibodies to carbohydrate antigens / Jamie Heimburg-Molinaro and Kate Rittenhouse-Olson -- Inhibition of glcosyltransferase activities as the basis for drug development / John Schutzbach and Inka Brockhausen -- Saturation transfer difference NMR spectroscopy as a technique to investigate protein-carbohydrate interactions in solution / Thomas Haselhorst, Anne-Christin Lamerz, and Mark von Izstein.

The use of monoclonal antibodies and lectins to identify changes in viral glycoproteins that are influenced by glycosylation : the case of respiratory syncytial virus attachment (G) glycoprotein / Joanna Rawling and José A. Melero -- Expression, glycosylation, and modification of the spike (S) glycoprotein of SARS-CoV / Shuo Shen, Timothy H.P. Tan, and Yee-Joo Tan -- Analysis of glycoproteins of viruses in the family bunyaviridae / Xiaohong Shi and Richard M. Elliott -- Secretion of respiratory syncytial virus fusion protein from insect cells using the baculovirus expression system / Boon-Huan Tan, Gaie Brown, and Richard J. Sugrue -- Characterization of the dengue virus envelope glycoprotein expressed in Pichia pastoris / Boon-Huan Tan, Jian Lin Fu, and Richard J. Sugrue -- Cloning, expression, and functional analysis of patient-derived hepatitis C virus glycoproteins / Alexander W. Tarr ... [et al.].Viruses and glycosylation : an overview / Richard J. Sugrue -- Interaction between respiratory syncytial virus and glycosaminoglycans, including heparan sulfate / Louay K. Hallak, Steven A. Kwilas, and Mark E. Peeples -- Expression of the severe acute respiratory syndrome coronavirus 3a protein and the assembly of coronavirus-like particles in the baculovirus expression system / Sehaam Khan, Mah-Lee Ng, and Yee-Joo Tan -- The C type lectins DC-SIGN and L-SIGN : receptors for viral glycoproteins / Pierre-Yves Lozach ... [et al.] -- Functional analysis of the N-linked glycans within the fusion protein of respiratory syncytial virus / Ping Li ... [et al.] -- Expression and purification of viral glycoproteins using recombinant vaccinia viruses for functional and structural studies / Zhu-Nan Li and David A. Steinhauer -- The use of two-dimensional SDS-PAGE to analyze the glycan heterogeneity of the respiratory syncytial virus fusion protein / Terence P. McDonald and Richard J. Sugrue --

"San Francisco's Laguna Honda Hospital is the last almshouse in the country, a descendant of the Hotel-Dieu (God's Hotel) that cared for the sick in the Middle Ages. Ballet dancers and rock musicians, professors and thieves--"anyone who had fallen, or, often, leapt, onto hard times" and needed extended medical care-ended up here. So did Victoria Sweet, who came for two months and stayed for twenty years.Laguna Honda, lower tech but human paced, gave Sweet the opportunity to practice a kind of attentive medicine that has almost vanished. Gradually, the place transformed the way she understood her work. Alongside the modern view of the body as a machine to be fixed, her extraordinary patients evoked an older idea, of the body as a garden to be tended. God's Hotel tells their story and the story of the hospital itself, which, as efficiency experts, politicians, and architects descended, determined to turn it into a modern "health care facility," revealed its own surprising truths about the essence, cost, and value of caring for body and soul"--Provided by publisher. "Choosing service in the last remaining almshouse in America, and tracing our understanding of medicine back to its medieval roots, a physician uncovers lost lessons in the care of body and soul"--Provided by publisher.Includes detailed explorations of Hildegard's medical practice and its occasional unexpected utility for modern problems.

1. Silver Stains for the Identification of Neuroendocrine Cell Types / L. Grimelius -- 2. Autometallographic Tracing of Gold, Silver, Bismuth, Mercury, and Zinc / G. Danscher, G. W. Hacker, and M. Stoltenberg -- 3. Silver- and Gold-Based Autometallography of Nanogold / J.E Hainfeld and R.D. Powell -- 4. Immunogold-Silver Staining for Light Microscopy Using Colloidal or Clustered Gold (Nanogold) / G.W. Hacker, A.L.M. Cheung, R.R. Tubbs, L. Grimelius, G. Danscher, and C. Hauser-Kronberger -- 5. The Protein A-Gold-Silver Staining Method / O. Fujimori -- 6. Microscopic Uses of Nanogold® / J.E Hainfeld, R.D. Powell, and FR. Furuya -- 7. Combined Fluorescent and Gold Probes for Microscopic and Morphological Investigations / R.D. Powell and J. Hainfeld -- 8. Detection of Human Papillomavirus by In Situ Hybridization Using an In Situ PCR Thermal Cycler / P. Jackson and F.A. Lewis -- 9. Supersensitive In Situ Hybridization by Tyramide Signal Amplification and Nanogold® Silver Staining: The Contribution of Autometallography and Catalyzed Reporter Deposition to the Rejuvenation of In Situ Hybridization / R.R. Tubbs, J. Pettay, T. Grogan, A.L.M. Cheung, R.D. Powell, J. Hainfeld, C. Hauser-Kronberger, and G.W. Hacker -- 10. Immunogold Labeling Techniques for Transmission Electron Microscopy: Applications in Cell and Molecular Biology / L. Lossi, P Aimar, E. Beltramo, and A. Merighi -- 11. Pre-Embedding Immunoelectron Microscopy with Nanogold® Immunolabeling, Silver Enhancement, and Its Stabilization by Gold / H. Sawada and M. Esaki -- 12. Gold Cluster Immunoprobes: Light and Electron Microscopy / J.M. Robinson, T. Takizawa, and D.D. Vandré -- 13. Highly Sensitive Ultrastructural Immunogold Detection Using Tyramide and Gold Enhancement / C. Schöfer and K. Weipoltshammer -- 14. In Situ Hybridization at the Electron Microscopic Level / C. Schöfer and K. Weipoltshammer -- 15. Immunogold-Silver Staining for Scanning Electron Microscopy in Cancer Research / B.-L. Wang, N. Flay, and G.W. Hacker -- 16. Immunogold-Silver Scanning Electron Microscopy Using Glycerol Liquid Substitution / J. Šamaj, H.-J. Ensikat, W. Barthlott, and D. Volkmann.

The golden mouse : a levels-of-organization perspective / Gary W. Barrett -- The golden mouse : taxonomy and natural history / George A. Feldhamer and Donald W. Linzey -- Population ecology of the golden mouse / Robert K. Rose -- Community ecology of the golden mouse / Cory C. Christopher and Guy N. Cameron -- Ecosystem ecology of the golden mouse / Steven W. Seagle -- Landscape ecology of the golden mouse / Jerry O. Wolff and Gary W. Barrett -- Relative abundance and conservation : is the golden mouse a rare species? / George A. Feldhamer and Anita T. Morzillo -- The golden mouse : a model of energetic efficiency / John D. Peles and Gary W. Barrett -- Nesting ecology of the golden mouse : an oikos engineer / Thomas M. Luhring and Gary W. Barrett -- Ectoparasites, bots, and vector-borne diseases associated with the golden mouse / Lance A. Durden -- Aesthetic landscapes of the golden mouse / Terry L. Barrett and Gary W. Barrett -- Future challenges and research opportunities : what do we really know? / Gary W. Barrett and George A. Feldhamer.

Social and ethical issues in medicine -- Principles of evaluation and management -- Preventive and environmental issues -- Aging and geriatric medicine -- Clinical pharmacology -- Genetics -- Principles of immunology and inflammation -- Cardiovascular disease -- Respiratory diseases -- Critical care medicine -- Renal and genitourinary diseases -- Gastrointestinal diseases -- Diseases of the liver, gallbladder, and bile ducts -- Hematologic diseases -- Oncology -- Metabolic diseases -- Nutritional diseases -- Endocrine diseases -- Women's health -- Diseases of bone and mineral metabolism -- Diseases of allergy and clinical immunology -- Rheumatic diseases -- Infectious diseases -- HIV and the acquired immunodeficiency syndrome -- Neurology -- Eye, ear, nose, and throat diseases -- Medical consultation -- Skin diseases.

Section I. Development and cell migration -- Section II. GnRH receptors -- Section III. Physiology and regulation.

Preface / Joseph D. Nally -- Contributors -- 1. Status and Applicability of U.S. Regulations: Current Good Manufacturing Practices in Manufacturing, Processing, Packaging, and Holding of Drugs / Joseph D. Nally -- 2. Finished Pharmaceuticals: General Provisions, Subpart A / Joseph D. Nally -- 3. Organization and Personnel, Subpart B / Joanne W. Cochran and Joseph D. Nally -- 4. Buildings and Facilities, Subpart C / Robert Del Ciello -- 5. Equipment, Subpart D / Robert Del Ciello, Joseph T. Busfield, and Steven Ostrove -- 6. Control of Components and Drug Product Containers and Closures , Subpart E / Arlyn R. Sibille -- 7. Production and Process Controls, Subpart F / Joseph D. Nally and Michael D. Karaim -- 8. Packaging and Labeling Control, Subpart G / Arlyn R. Sibille -- 9. Holding Distribution, Subpart H / Joseph D. Nally -- 10. Laboratory Controls, Subpart I / Wayne J. DeWitte and Lex M. Hoinowski -- 11. Records and Reports, Subpart J / Arlyn R. Sibille, Steven Ostrove, Joseph D. Nally, and Laura L. Nally -- 12. Returned and Salvaged Drug Products, Subpart K / Joseph D. Nally -- 13. Repacking and Relabeling / Joseph D. Nally -- 14. Quality Systems and Risk Management Approaches / Joseph D. Nally and Laura L. Nally -- 15. Clinical Trial Supplies and Current Good Manufacturing / Graham Bunn -- 16. Contracting and Outsourcing / Graham Bunn -- 17. Active Pharmaceutical Ingredients / P. Denis Celentano -- 18. Bulk Pharmaceutical Excipient GMPs / Irwin Silverstein -- 19. Recalls, Warning Letters, Seizures and Injunctions: CGMP Enforcement Alternatives in the United States / Joseph D. Nally -- 20. Control Substances Safeguards (21 CFR 1300, et seq.) / Joseph D. Nally -- 21. The Inspection Procedures for Compliance in the United States: The Regulatee is Inspected; The Rational for Inspection (21 USC 373, 374) / Joseph D. Nally -- 22. FDA Pre-Approval Inspections/Investigations: The Road from Scale-Up and Post-Approval Changes in the Food and Drug Modernization Act / Joseph D. Nally -- 23. World-Wide Good Manufacturings Practices / Joseph D. Nally -- 24. Quality Approaches: ISO 9000, Malcolm Baldrige, and Six Sigma / Joseph D. Nally -- Appendix A: Center for Drug Evaluation and Research: List of Guidance Documents -- Appendix B: ICH Guidelines -- Appendix C: Food and Drug Administration (FDA) Office Regulatory Affairs (ORA) Compliance Policy Guides -- Index.

Drug invention and the pharmaceutical industry -- Pharmacokinetics: the dynamics of drug absorption, distribution, metabolism, and elimination -- Pharmacodynamics: molecular mechanisms of drug action -- Drug toxicity and poisoning -- Membrane transporters and drug response -- Drug metabolism -- Pharmacogenetics -- Neurotransmission: the autonomic and somatic motor nervous systems -- Muscarinic receptor agonists and antagonists -- Anticholinesterase agents -- Agents acting at the neuromuscular junction and autonomic ganglia -- Adrenergic agonists and antagonists -- 5-Hydroxytryptamine (serotonin) and dopamine -- Neurotransmission and the central nervous system -- Drug therapy of depression and anxiety disorders -- Pharmacotherapy of psychosis and mania -- Hyponotics and sedatives -- -- Opioids, analgesia, and pain management -- General anesthetics and therapeutic gases -- Local anesthetics -- Pharmacotherapy of the epilepsies -- Treatment of central nervous system degenerative disorders -- Ethanol and methanol -- Drug addiction -- Regulation of renal function and vascular volume -- Renin and angiotensin -- Treatment of myocardial ischemia and hypertension -- Pharmacotherapy of congestive heart failure -- Anti-arrhythmic drugs -- Blood coagulation and anticoagulant, fibrinolytic, and antiplatelet drugs -- Drug therapy for hypercholesterolemia and dyslipidemia -- Histamine, bradykinin, and their antagonists -- Lipid-derived autacoids: eicosanoids and platelet-activating factor -- Anti-inflammatory, antipyretic, and analgesic agents; pharmacotherapy of gout -- Immunosuppressants, tolerogens, and immunostimulants -- Pulmonary pharmacology -- Hematopoietic agents: growth factors, minerals, and vitamins --Introduction to endocrinology: the hypothalamic-pituitary axis -- Thyroid and anti-thyroid drugs -- Estrogens and progestins -- Androgens -- ACTH, adrenal steroids, and pharmacology of the adrenal cortex -- Endocrine pancreas and pharmacotherapy of diabetes mellitus and hypoglycemia -- Agents affecting mineral ion homeostasis and bone turnover -- Pharmacotherapy of gastric acidity, peptic ulcers, and gastroesophageal reflux disease -- Treatment of disorders of bowel motility and water flux; anti-emetics; agents used in biliary and pancreatic disease -- Pharmacotherapy of inflammatory bowel disease -- General principles of antimicrobial therapy -- Chemotherapy of malaria -- Chemotherapy of protozoal infections: amebiasis, giardiasis, trichomoniasis, trypanosomiasis, leishmaniasis, and other protozoal infections -- Chemotherapy of helminth infections -- Sulfonamides, trimethoprim-sulfamethoxazole, quinolones, and agents for urinary tract infections -- Penicillins, cephalosporins, and other β-lactam antibiotics -- Aminoglycosides -- Protein synthesis inhibitors and miscellaneous antibacterial agents -- Chemotherapy of tuberculosis, mycobacterium avium complex disease, and leprosy -- Antifungal agents -- Antiviral agents (nonretroviral) -- Antiretroviral agents and treatment of HIV infection -- General principles of cancer chemotherapy -- Cytotoxic agents -- Targeted therapies: tyrosine kinase inhibitors, monoclonal antibodies, and cytokines -- Natural products in cancer chemotherapy: hormones and related agents -- Ocular pharmacology -- Dermatological pharmacology -- Contraception and pharmacotherapy of obstetrical and gynecological disorders -- Environmental toxicology; carcinogens and heavy metals -- Appendix I: Principles of prescription order writing and patient compliance -- Appendix II: Design and optimization of dosage regimens: pharmacokinetic data.

Evolution of psychiatric diagnosis -- Mood (affective) disorders -- Schizophrenic disorders -- Panic disorder and phobias -- Posttraumatic stress disorder -- Obsessive-compulsive disorder -- Eating disorders -- Somatization disorder (hysteria) -- Antisocial personality (sociopathy) -- Borderline personality disorder -- Alcoholism -- Drug dependence -- Delirium and dementia (acute and chronic brain syndromes) -- The psychiatric evaluation.

Web -- Advanced web -- News and blogs -- Extending Google -- Google maps -- Gmail -- Webmastering -- Programming Google.

"Using the two-page, templated organization of the 5-Minute Consult series, Gorbach's 5-Minute Infectious Diseases Consult, Second Edition provides comprehensive coverage for clinicians dealing with infectious diseases. The two major sections of the book cover chief complaints and individual diseases and disorders. Additional materials include summary information about individual microorganisms as well as numerous elements related to drugs for infectious disorders. A team of international authorities provides actionable information, supported by current research and practice guidelines.Features Include: Comprehensive coverage of infectious diseases, important symptoms, microorganisms, and anti-infective drugs Coverage of emerging infectious diseases such as H1N1 flu Increased coverage of tropical diseases Two-page, tightly written chapters Updated information about management of HIV/AIDS "--Provided by publisher.

University of Pennsylvania -- Before Kelley -- Kelley the builder -- Kelley in trouble -- After Kelley -- Johns Hopkins University and Hospital -- Separate governance

v. 1. Head and neck -- v. 2. Upper extremities -- v. 3. Torso, pelvis, and lower extremities.

Discusses how to plan and develop a grant proposal, what reviewers look for in applications, and covers recent changes at National Institutes of Health (NIH) and the National Science Foundation (NSF). Also includes information on private foundation proposals.

Thorax -- Abdomen -- Pelvis and perineum -- Back -- Lower limb -- Upper limb -- Head -- Neck -- Cranial nerves.