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- G protein coupled receptors. Modeling, activation, interactions and virtual screening — Genetic analysis of complex diseases. 2nd ed. (141)
- Genetic and molecular epidemiology of multiple myeloma — Getting started with Simulink response optimization 3. Version 3. (141)
- Getting started with Stateflow 7. Version 7. — Grand challenge for the future vaccines for poverty-related diseases from bench to field (141)
- Grant application writer's handbook. 4th ed. — Gynecological imaging a reference guide to diagnosis (141)
- This state-of-the-art book is written by a group of international experts to provide insight into the newest breakthroughs from basic pathogenesis to clinical aspects of multiple myeloma. The book provides a comprehensive overview of the genetic and molecular epidemiology of multiple myeloma in order to get a more refined and conclusive understanding of this disease. Areas, which are covered include the characterization of different myeloma entities by genomics and proteomics, notch signaling and targeting protein translation as a new treatment for multiple myeloma, cell cycle control of plasma cell differentiation, the role of bone disease in the pathogenesis of multiple myeloma as well as the molecular interaction of multiple myeloma with a microenvironment. Genetic and Molecular Epidemiology of Multiple Myeloma is a valuable resource for cancer researchers, medical, surgical, and radiation oncologists.
- Genetic basis for respiratory control disorders 2007Springer1. Respiratory control disorders: from genes to patients and back / David Gozal -- 2. Hereditary aspects of respiratory control in health and disease in humans / John V. Weil -- 3. Phox2b and the homeostatic brain / Jean-François Brunet and Christo Goridis -- 4. Congenital central hypoventilation syndrome: from patients to gene discovery / Ha Trang -- 5. Structural and functional brain abnormalities in congenital central hypoventilation syndrome / Ronald M. Harper... [et al.] -- 6. In vitro study of Pho2xb gene mutations in congenital central hypoventilation syndrome / Tiziana Bachetti and Isabella Ceccherini -- 7. Sudden infant death syndrome: study of genes pertinent to cardiorespiratory and autonomic regulation / Debra E. Weese-Mayer... [et al.] -- 8. The genetic basis for obstructive sleep apnea: what role for variation in respiratory control? / Susan Redline, Sanjay R. Patel -- 9. Apnea and irregular breathing in animal models: a physiogenomic approach / Motoo Yamauchi ... [et al.] -- 10. Genetic determinants of respiratory phenotypes in mice / Clarke G. Tankersley -- 11. Genes and development of respiratory rhythm generation / Jean Champagnat... [et al.] -- 12. Transcription factor control of central respiratory neuron development / Bruno C. Blanchi and Michael H. Sieweke -- 13. Lessons from mutant newborn mice with respiratory control deficits / Claude Gaultier -- 14. Tentative mouse model for the congenital central hypo-ventilation syndrome: heterozygous Phox2b mutant newborn mice / Jorge Gallego... [et al.] -- 15. Respiratory control abnormalities in necdin-null mice: implications for the pathogenesis of Prader-Willi syndrome / John J. Greer and Rachel Wevrick -- 16. Possible role of bioaminergic systems in the respiratory disorders of Rett syndrome / John Bissonnette and Gerard Hilaire -- 17. Respiratory plasticity following intermittent hypoxia: a guide for novel therapeutic approaches to ventilatory control disorders? / Gordon s Mitchell.
- Genetic basis of common diseases. 2nd ed. 2002MyiLibrary
- Genetic cardiomyopathies a clinical approach 2013Springer
- Print MaterialComplicated shadows : a critique of autonomy in genetic counseling / Robert G. Resta -- Actively engaging with patients in decision making / Andrea Zanko and Michelle Fox -- Risk communication : a complex process / Shannan DeLany Dixon and Yasmine L. Konheim-Kalkstein -- Grieving : an inevitable journey / Elizabeth Gettig -- Facing patient anger / Bonnie Jeanne Baty -- Resistance and adherence : understanding the patient's perspective / Jon Weil -- Countertransference : making the unconscious conscious / Jon Weil -- Honoring diversity : cultural competence in genetic counseling / Linwood J. Lewis -- Genetic counseling strategies for working with families / Deborah L. Eunpu -- Developmentally based approaches for counseling children and adolescents / Stephanie Austin -- Genetic counseling for women with intellectual disabilities / Brenda Finucane -- Genetic counselors : caring mindfully / June A. Peters -- Professional development : reflective genetic counseling practice / Kimberly W. Zahm -- Mobilizing genetic counselor leadership skills / Nancy P. Callanan.
- Genetic damage in human spermatozoa 2014SpringerThere are several types of damage that can be found in the male gamete. Genetic damage in spermatozoa can originate during spermatogenesis, or it can originate during transit in both male and female genital tracts. Damage can also be due to aging, environmental or iatrogenic conditions, as well as to the protocols to cryopreserve and to select spermatozoa in assisted reproduction techniques. This book provides a comprehensive resource for all possible DNA damages in sperm, the relation to fertility and infertility, and possible transgenerational heritable effects.
- Genetic democracy philosophical perspectives 2008SpringerIntroduction : the scope and importance of genetic democracy / Veikko Launis -- The prerequisites for genetic democracy / Helena Siipi -- Ethical expertise in democratic societies / Eerik Lagerspetz -- Towards global bioethics : the UNESCO universal declaration on bioethics and human rights / Henk ten Have -- Autonomy and genetic privacy / Juha Räikkä -- Values, rights and GMO : against radicalism -- The precautionary principle and the risks of modern agri-biotechnology / Marko Ahteensuu -- Population databanks and democracy in light of the Icelandic experience / Vilhjálmur Árnason and Stefán Hjörleifsson -- Equality and community in public deliberation : genetic democracy in Taiwan / Terence Hua Tai and Wen-Tsong Chiou -- Genetic resources, genetic democracy and genetic equity / Keekok Lee -- Moral constraints on permissible genetic design / Thomas Pogge.
- Genetic diagnosis of endocrine disorders. 1st ed. 2010ScienceDirect2010 ClinicalKeyMechanisms of mutation -- Pancreas - Genetic testing in diabetes mellitus: a clinical guide to monogenic diabetes -- Obesity -- Syndromes of severe insulin resistance and/or lipodystrophy -- Pituitary -- Functioning pituitary adenomas -- Diabetes insipidus -- States of pituitary hypofunction -- Thyroid -- Congenital defects of thyroid hormone synthesis -- Developmental abnormalities of the thyroid -- Syndromes of reduced sensitivity to thyroid hormone -- Molecular genetics of thyroid cancer: pathogenetic significance and clinical applications -- Parathyroid and bone -- Genetics of hyperparathyroidism including parathyroid cancer -- Genetic diagnosis of skeletal dysplasias -- Vitamin D disorders -- Adrenal -- Congenital adrenal hyperplasia -- Genetics of adrenocortical tumors (ACT) and hypersecretory syndromes -- Hereditary pheochromocytoma and multiple endocrine neoplasia type 2 (MEN2) -- Genetic conditions associated with congenital adrenocortical insufficiency or glucocorticoid and/or mineralocorticoid resistance -- Reproductive -- Genetic considerations in the evaluation of menstrual cycle irregularities -- Genetic diagnosis of hypogonadotropic hypogonadism and Kallmann syndrome -- Disorders of sex development -- Genetic defects of androgen resistance -- Multisystem disorders -- Multiple endocrine neoplasia type 1 (MEN1) -- Genetics of polyglandular failure -- Growth -- Genetic diagnosis of growth failure -- Counseling and laboratory -- Genetic counseling -- Setting up a laboratory.
- Genetic disorders among Arab populations. 2nd ed. 2010Springer
- Print Material"The population of the Indian subcontinent consists of a fine amalgamation of people from diverse tribal, cultural, religious and social backgrounds. Mortality and morbidity from a vast number of medical and surgical conditions is significant and well above compared to the developed countries. Although a large component of the human health problem is related to infection, malnutrition and other preventable causes, a significant proportion is linked to hereditary factors reflecting in the form of chromosomal, single gene and complex medical diseases. Unusual and unique Mendelian disorders are not uncommon and a number of common medical conditions, such as ischemic heart disease and diabetes mellitus are relatively more prevalent among those living in the developing countries of the Indian subcontinent and as well as among the migrant population groups in the western world. However, true burden of the inherited disorders among the Asian Indians is not known, and probably underestimated. -- This text includes a detailed and concise account of the social and cultural diversity, medical demography, genetic epidemiology, consanguinity and common genetic disorders affecting people from the Indian subcontinent. In addition, specific issues of genetic services in various regions are addressed. This volume also provides a glossary for the benefit of non-genetic professionals and is aimed at a wide audience including physicians, genetic professionals, public health consultants, medical demographers, medica/social anthropologists and health administrators." -- [Publisher-supplied data]
- Print MaterialIntroduction : whither gene-environment interactions? ? Michael Rutter -- Gene-environment interaction : overcoming methodological challenges / Rudolf Uher -- Gene-environment interaction and behavioral disorders : a developmental perspective based on endophenotypes / Marco Battaglia, Cecilia Marino, Michel Maziade, Massimo Molteni and Francesca D'Amato -- Use of monozygotic twins to investigate the relationship between 5HTTLPR genotype, depression and stressful life events : an application of item response theory / Naomi R. Wray, William L. Coventry, Michael R. James, Grant W. Montgomery, Lindon J. Eaves and Nicholas G. Martin -- Role of gene-stress interactions in gene finding studies / Harold Snieder, Xiaoling Wang, Vasiliki Lagou, Brenda W. J. H. Penninx, Harriëtte Riese and Catharina A. Hartman -- Practice and public policy in the era of gene-environment interactions / Kenneth A. Dodge -- Gene-environment interaction and the metabolic syndrome / Kristi B. Adamo and Frédérique Tesson -- Longitudinal studies of gene-environment interaction in common diseases - good value for money? / Stephen P. Robertson and Richie Poulton -- Gene-environment interactions in breast cancer / Kee-Seng Chia -- Unbiased forward genetics and systems biology approaches to understanding how gene-environment interactions work to predict susceptibility and outcomes of infections / Malak Kotb, Nourtan Fathey, Ramy Aziz, Sarah Rowe, Robert W. Williams and Lu Lu -- Gene-environment interactions in environmental lung diseases / Steven R. Kleeberger and Hye-Youn Cho -- Gene-environment interaction in complex diseases : asthma as an illustrative case / Fernando D. Martinez -- Conclusions : taking stock and looking ahead / Michael Rutter.
- Genetic engineering v. 27-28, 2006-2007.Springerv. 28, 2007 Springer
- Genetic engineering of mesenchymal stem cells 2006Springer
- Genetic epidemiology 2009Springer ProtocolsMolecular Genetics and Genetic Variation / Mohammed-Elfatih Twfieg, M. Dawn Teare -- Terminology, Concepts, and Models in Genetic Epidemiology / M. Dawn Teare, Mauro F. Koref -- An Introduction to Epidemiology / Cother Hajat -- Genetic Distance and Markers Used in Linkage Mapping / Kristina Allen-Brady, Nicola J. Camp -- Approaches to Genetic Linkage Analysis / M. Dawn Teare -- Fine-Scale Structure of the Genome and Markers Used in Association Mapping / Karen Curtin, Nicola J. Camp -- Genome-Wide Association Studies / Mark M. Iles -- Candidate Gene Association Studies / M. Dawn Teare -- Family-Based Association Studies / Frank Dudbridge -- Genome Variation: A Review of Web Resources / Andrew Collins, William J. Tapper -- Advanced Methods in Twin Studies / Jaakko Kaprio, Karri Silventoinen -- Mendelian Randomisation: A Tool for Assessing Causality in Observational Epidemiology / Nuala A. Sheehan, Sha Meng, Vanessa Didelez -- Copy Number Variation / Louise V. Wain, Martin D. Tobin -- Epigenetic Variation / Kevin Walters -- Modeling the Effect of Susceptibility Factors (HLA and PTPN22) in Rheumatoid Arthritis / Hervé Perdry, Françoise Clerget-Darpoux -- Coronary Artery Disease: An Example Case Study / Jennifer H. Barrett -- The Genetic Epidemiology of Obesity: A Case Study / Laura M. Johnson.
- Genetic epidemiology 2011Springer ProtocolsMolecular genetics and genetic variation / Mohammed-Elfatih Twfieg and M. Dawn Teare -- Terminology, concepts, and models in genetic epidemiology / M. Dawn Teare and Mauro F. Santibàñez Koref -- An introduction to epidemiology / Cother Hajat -- Genetic distance and markers used in linkage mapping / Kristina Allen-Brady and Nicola J. Camp -- Approaches to genetic linkage analysis / M. Dawn Teare -- Fine-scale structure of the genome and markers used in association mapping / Karen Curtin and Nicola J. Camp -- Genome-wide association studies / Mark M. Iles -- Candidate gene association studies / M. Dawn Teare -- Family-based association studies / Frank Dudbridge -- Genome variation : a review of web resources / Andrew Collins and William J. Tapper -- Advanced methods in twin studies / Jaakko Kaprio and Karri Silventoinen -- Mendelian randomisation : a tool for assessing causality in observational epidemiology / Nuala A. Sheehan, Sha Meng, and Vanessa Didelez -- Copy number variation / Louise V. Wain and Martin D. Tobin -- Epigenetic variation / Kevin Walters -- Modeling the effect of susceptibility factors (HLA and PTPN22) in rheumatoid arthritis / Hervé Perdry and Françoise Clerget-Darpoux -- Coronary artery disease : an example case study / Jennifer H. Barrett -- The genetic epidemiology of obesity : a case study / Laura M. Johnson.
- Genetic instabilities and neurological diseases. 2nd ed. 2006ScienceDirectOverview. Overview of the field / Tetsuo Ashizawa and Robert D. Wells -- Myotonic dystrophy. Myotonic dystrophies: an overview / Tetsuo Ashizawa and Peter S. Harper. The RNA-mediated disease process in myotonic dystrophy / Charles A. Thornton, Maurice S. Swanson, and Thomas A. Cooper. cis Effects of CTG expansion in myotonic dystrophy type 1 / Sita Reddy and Sharan Paul. Normal and pathophysiological significance of myotonic dystrophy protein kinase / Derick G. Wansink, René E.M.A. van Herpen, and Bé Wieringa. Biochemistry of myotonic dystrophy protein kinase / Ram Singh and Henry F. Epstein. Clinical and genetic features of myotonic dystrophy type 2 / Jamie M. Margolis, Laura P.W. Ranum, and John W. Day. Myotonic dystrophy type 2: clinical and genetic aspects / Ralf Krahe, Linda L. Bachinski, and Bjarne Udd. The subtelomeric D4Z4 repeat instability in facioscapulohumeral muscular dystrophy / Silvére van der Maarel, Rune R. Frants, and George W. Padberg -- Fragile X syndrome. Fragile X syndrome and fragile X-associated tremor/ataxia syndrome / Randi J. Hagerman and Paul J. Hagerman. Animal models of fragile X syndrome: mice and flies / Ben A. Oostra and David L. Nelson. Chromosomal fragile sites: mechanisms of cytogenetic expression and pathogenic consequences / Robert I. Richards -- Kennedy's disease. Clinical features and molecular biology of Kennedy's disease / CheunJu Chen and Kenneth H. Fischbeck -- Huntington's disease. Molecular pathogenesis and therapeutic targets in Huntington's disease / John S. Bett, Gillian P. Bates, and Emma Hockly. Molecular pathogenesis of Huntington's disease: the role of excitotoxicity / Mahmoud A. Pouladi ... [et al.] Huntington's disease-like 2 / Russell L. Margolis ... [et al.] -- Friedreich's ataxia. Friedreich's ataxia / Massimo Pandolfo. Experimental therapeutics for Friedreich's ataxia / Robert B. Wilson. Evolution and instability of the GAA triplet-repeat sequence in Friedreich's ataxia / Irene De Biase, Astrid Rasmussen, and Sanjay I. Bidichandani. Mouse models for Friedreich's ataxia / Hélène Puccio. Triplexes, sticky DNA, and the (GAA-TTC) trinucleotide repeat associated with Friedreich's ataxia / Leslie S. Son and Robert D. Wells -- Spinocerebellar ataxias. Phosphorylation of ataxin-1: a link between basic research and clinical application in spinocerebellar ataxia type 1 / Kerri M. Carlson and Harry T. Orr. Spinocerebellar ataxia type 2 / Stefan M. Pulst. Machado-Joseph disease/spinocerebellar ataxia type 3 / Henry Paulson. Spinocerebellar ataxia type 6 / Hidehiro Mizusawa and Kinya Ishikawa. Pathogenesis of spinocerebellar ataxia type 7: new insights from mouse models and ataxin-7 function / Dominique Helmlinger and Didier Devys. Spinocerebellar ataxia type 7: clinical features to cellular pathogenesis / Gwenn A. Garden ... [et al.] Molecular genetics of spinocerebellar ataxia type 8 / Yoshio Ikeda ... [et al.] Spinocerebellar ataxia type 10: a disease caused by an expanded (ATTCT)n pentanucleotide repeat / Tetsuo Ashizawa. DNA structures and genetic instabilities associated with spinocerebellar ataxia type 10 (ATTCT)n·(AGAAT)n repeats suggest a DNA amplification model for repeat expansion / Vladimir N. Potman ... [et al.] Spinocerebellar ataxia type 12 / Susan E. Holmes ... [et al.] Spinocerebellar ataxia 17 and Huntington's disease-like 4 / Giovanni Stevanin and Alexis Brice -- Other polyamino acid repeats. Polyalanine and polyglutamine diseases: possible common mechanisms? / Aida Abu-Baker and Guy A. Rouleau -- Biophysics of polyQ. Chemical and physical properties of polyglutamine repeat sequences / Ronald Wetzel -- In vivo instability studies. Somatic mosaicism of expanded CAG·CTG repeats in humans and mice: dynamics, mechanisms, and consequences / Peggy F. Shelbourne and Darren G. Monckton. Transgenic mouse models of unstable trinucleotide repeats: toward an understanding of disease-associated repeat size mutation / Mário Gomes-Pereira, Laurent Foiry, and Geneviève Gourdon -- Insect models. Drosophila models of polyglutamine disorders / George R. Jackson, Tzu-Kang Sang, and J. Paul Taylor -- Instability mechanisms in vivo and in vitro. Involvement of genetic recombination in microsatellite instability / Ruhee Dere, Micheal L. Hebert, and Marek Napierala. Bending the rules: unusual nucleic acid structures and disease pathology in the repeat expansion diseases / Karen Usdin. Replication of expandable DNA repeats / Sergei M. Mirkin. Error-prone repair of slipped (CTG)·(CAG) repeats and disease-associated expansions / Gagan B. Panigrahi ... [et al.] DNA repair models for understanding triplet repeat instability / Yuan Liu, Rajendra Prasad, and Samuel H. Wilson. Models of repair underlying trinucleotide DNA expansion / Irina V. Kovtun and Cynthia T. McMurray. Transcription and triplet repeat instability / Yunfu Lin, Vincent Dion, and John H. Wilson. Structural characteristics of trinucleotide repeats in transcripts / Wlodzimierz J. Krzyzosiak, Krzysztof Sobczak, and Marek Napierala -- Mutations in flanking sequences. Gross rearrangements caused by long triplet and other repeat sequences / Albino Bacolla [et al.] -- Cancer and genetic instability. Microsatellite instability in cancer / Michael J. Siciliano.
- Genetic landscape of diabetes 2004NCBI Bookshelf
- Genetic models of schizophrenia 2009ScienceDirect
- Genetic modification of hematopoietic stem cells methods and protocols 2009Springer ProtocolsImmunomagnetic enrichment of human and mouse hematopoietic stem cells for gene therapy applications / Guillermo Guenechea, Jose C. Segovia, and Juan A. Bueren -- Isolation of human and mouse hematopoietic stem cells / Yuk Yin Ng ... [et al.] -- Murine hematopoietic stem cell transduction using retroviral vectors / Ute Modlich ... [et al.] -- Genetic modification of human hematopoietic cells: preclinical optimization of oncoretroviral-mediated gene transfer for clinical trials / Tulin Budak-Alpdogan and Isabelle Rivière -- Short-term culture of human CD34⁺ cells for lentiviral gene transfer / Francesca Santoni de Sio and Luigi Naldini -- T cell culture for gammaretroviral transfer / Sebastian Newrzela, Gunda Brandenburg, and Dorothee von Laer -- Retroviral transduction of murine primary T lymphocytes / James Lee, Michel Sadelain, and Renier Brentjens -- Lentiviral vector gene trasfer into human T cells / Els Verhoeyen, Caroline Costa, and Francois-Loic Cosset -- DNA transposons for modification of human primary T lymphocytes / Xin Huang ... [et al.] -- Retroviral gene transfer into primary human natural killer cells / Evran Alici, Tolga Sutlu, and M. Sirac Dilber -- Lentiviral vector-mediated genetic programming of mouse and human dendritic cells / Renata Stripecke -- In situ (in vivo) gene transfer into murine bone marrow stem cells / Dao Pan -- In vivo and ex vivo gene transfer in thymocytes and thymocyte precursors / Oumeya Adjali ... [et al.] -- Design and production of retro- and lentiviral vectors for gene expression in hematopoietic cells / Axel Schambach, William P. Swaney, and Johannes C.M. van der Loo -- Knock-down of gene expression in hematopoietic cells / Michaela Scherr, Letizia Venturiani, and Matthias Eder -- The use of retroviral vectors for tet-regulated gene expression in cell populations / Rainer Löw -- Detection of replication competent retrovirus and lentivirus / Lakshmi Sastry and Kenneth Cornetta -- Release testing of retroviral vectors and gene-modified cells / Diana Nordling, Anne Kaiser, and Lilith Reeves -- Copy number determination of genetically-modificed hematopoietic stem cells / Todd Schuesler ... [et al.] -- Tissue procurement for molecular studies using laser-assisted microdissection / Ulrich Lehmann and Hans Kreipe -- Leukemia diagnosis in murine bone marrow transplantation models / Zhixiong Li, Ute Modlich, and Anjali Mishra -- Humanized mouse models to study the human haematopoietic stem cell compartment / Dominique Bonnet -- Canine models of gene-modified hematopoiesis / Brian C. Beard and Hans-Peter Kiem -- Detection of retroviral integration sites by linear amplification-mediated PCR and tracking of individual integration clones in different samples / Manfred Schmidt ... [et al.] -- Retroviral insertion site analysis in dominant haematopoietic clones / Olga S. Kustikova, Ute Modlich, and Boris Fehse -- Tracking gene-modified T cells in vivo / Alessandra Recchia and Fulvio Mavilio -- DNA microarray studies of hematopoietic subpopulations / Karin Pike-Overzet ... [et al.] -- Quantification of genomic mutations in murine hematopoietic cells / Hartmut Geiger ... [et al.] -- Proteomics studies after hematopoietic stem cell transplantation / Eva M. Weissinger, Petra Zürbig, and Arnold Ganser -- Spectral karyotyping and fluorescence in situ hybridization of murine cells / Cornelia Rudolph and Brigitte Schlegelberger -- Database setup for preclinical studies of gene-modified hematopoiesis / Brenden Balcik, Elke Grassman, and Lilith Reeves -- The US and EU regulatory perspectives on the clinical use of hematopoietic stem/progenitor cells genetically modified ex vivo by retroviral vectors / Carolyn A. Wilson and Klaus Cichutek.
- Section 1 Muscular Dystrophies -- Duchenne Muscular Dystrophy -- Duchenne Muscular Dystrophy carrier -- Becker Muscular Dystrophy -- Emery-Dreifuss Muscular Dystrophy type 1 -- Emery-Dreifuss Muscular Dystrophy type 2 -- Limb Girdle Muscular Dystrophy type 1B -- Limb Girdle Muscular Dystrophy type 1C -- Limb Girdle Muscular Dystrophy type 1F -- Limb Girdle Muscular Dystrophy type 2A -- Limb Girdle Muscular Dystrophy type 2B -- Limb Girdle Muscular Dystrophy type 2C -- Limb Girdle Muscular Dystrophy type 2D -- Limb Girdle Muscular Dystrophy type 2E -- Limb Girdle Muscular Dystrophy type 2F -- Limb Girdle Muscular Dystrophy type 2I -- Limb Girdle Muscular Dystrophy type 2K -- Limb Girdle Muscular Dystrophy type 2N -- Congenital Muscular Dystrophy type 1A -- Congenital Muscular Dystrophy type 1C -- Congenital Muscular Dystrophy with rigid spine -- Congenital Muscular Dystrophy with integrin-alpha-7 deficiency -- Congenital Muscular Dystrophy, Ullrich type -- Bethlem myopathy -- Facio Scapulo Humeral Muscular Dystrophy type 1A -- Facio Scapulo Humeral Muscular Dystrophy type 2 -- Section 2: Congenital Myopathies -- Congenital Multi-Mini-Core Myopathy -- Congenital Central-Core Myopathy with Malignant Hyperthermia -- Congenital Centronuclear Myopathy type 1 -- Congenital Hyaline Body Myopathy -- Congenital Myotubular Myopathy -- Congenital Nemaline Myopathy type 2 -- Congenital Fiber Type Disproportion type 1 -- Congenital Fiber Type Disproportion -- Congenital Myofibrillar Myopathy type 1 -- Congenital Myofibrillar Myopathy type 6 -- Congenital Tubular Aggregate Myopathy -- Hereditary Inclusion Body Myopathy type 2 -- Section 3: Ion Channel Disorders -- Myotonic Dystrophy type 1, Steinert Disease -- Congenital Myotonic Dystrophy -- Myotonic Dystrophy type 2, Proximal Myotonic Myopathy -- Congenital Myotonia, Thomsen Disease -- Hyperkalemic Periodic Paralysis -- Hypokalemic Periodic Paralysis type 1 -- Slow-channel Congenital Myasthenic Syndrome -- Congenital Myasthenic Syndrome -- Brody Disease -- Section 4: Metabolic Myopathies -- Glycogenosis type 2, Pompe Disease -- Glycogenosis type 3, Cori-Forbes Disease -- Glycogenosis type 5, McArdle Disease -- Danon Disease -- Kearns-Sayre Syndrome -- Chronic Progressive External Ophthalmoplegia -- MELAS (Myopathy, Encephalopathy, Lactic Acidosis, Stroke-like) -- Leigh Syndrome due to COX Deficiency -- Mitochondrial Encephalopathy with COX Deficiency -- Coenzyme Q10 Deficiency -- Multiple Symmetrical Lipomatosis -- NARP (Neuropathy, Ataxia, Retinitis Pigmentosa) -- SANDO (Sensory Ataxic Neuropathy, Dysarthria, Ophthalmoparesis) -- Systemic Primary Carnitine Deficiency -- Neutral Lipid Storage Disease with Ichthyosis -- Neutral Lipid Storage Disease with Myopathy -- Multiple Acyl-CoA Dehydrogenase Deficiency -- Carnitine-Palmitoyl-Transferase-II Deficiency -- Niemann-Pick Disease type C1 -- Section 5: Neurogenic Disorders -- Spinal Muscular Atrophy type 1, Werdnig-Hoffmann Disease -- Spinal Muscular Atrophy type 2 -- Spinal Muscular Atrophy type 3, Kugelberg-Welander Disease -- Spinal Bulbar Muscular Atrophy, Kennedy Disease -- Charcot-Marie-Tooth Disease type 1A -- Charcot-Marie-Tooth Disease type 1B -- Charcot-Marie-Tooth Disease neuronal type -- Charcot-Marie-Tooth Disease type 4A -- Charcot-Marie-Tooth Disease with pyramidal features -- Charcot-Marie-Tooth Disease type X1 -- Distal Spinal Muscular Atrophy -- Hereditary Neuropathy with Pressure Palsies -- Friedreich Ataxia -- Spastic Ataxia, Charlevoix-Saguenay type -- Ataxia-Telangiectasia, Louis-Bar Syndrome -- Spastic Paraparesis type 4 -- Spastic Paraparesis type 7 -- Optic Atrophy Plus Syndrome -- Amyotrophic Lateral Sclerosis type 1 -- Amyotrophic Lateral Sclerosis.
- Genetic programming 11th European Conference, EuroGP 2008, Naples, Italy, March 26-28, 2008 : proceedings 2008Springer
- Genetic recombination in cancer 2003ScienceDirect
- "The manner in which genetic research associated with addiction is conducted, interpreted and translated into clinical practice and policy initiatives raises important social, ethical and legal issues. Genetic Research on Addiction fulfils two key aims; the first is to identify the ethical issues and requirements arising when carrying out genetically-based addiction research, and the second is to explore the ethical, legal and public policy implications of interpreting, translating and applying this research. The book describes research guidelines on human protection issues such as improving the informed consent process, protecting privacy, responsibilities to minors and determining whether to accept industry funding. The broader public health policy implications of the research are explored and guidelines offered for developing effective social interventions. Highly relevant for clinicians, researchers, academics and policy-makers in the fields of addiction, mental health and public policy"--Provided by publisher.
- Print Materialv. 1. Mental and physical traits of a thousand gifted children / L.M. Terman, assisted by B.T. Baldwin, and others -- v. 2. The early mental traits of three hundred geniuses / C.M. Cox, assisted by L.O. Gillan and others -- v. 3. The promise of youth; follow-up studies of a thousand gifted children / B.S. Burks and others -- v. 4. The gifted child grows up; twenty-five years' follow-up of a superior group / L.M. Terman and M.H. Oden -- v. 5. The gifted group at mid-life; thirty-five years' follow-up of the superior child / L.M. Terman and M.H. Oden.
- Genetic testing 2003Wellcome Trust
- Print Material
- Genetic variants in Alzheimer's disease 2013SpringerSince 2009, a revolution has been witnessed in Alzheimer's Disease genetics. New genetic links are being discovered at an unprecedented pace and our understanding of the molecular mechanisms of neurodegeneration have taken a quantum leap forward. This book provides a thorough description of the genes that have been implicated in the aetiology of late-onset Alzheimer's disease (LOAD) based on evidence of genetic association. These "AD susceptibility genes" are described both in their genomic and cellular context, as well as with respect to their known or suspected molecular functions. Although these genes are not sufficient to explain all of the genetic contributions to LOAD, they represent the best replicated set of genes to date. Undoubtedly the list will grow as more advanced genomic approaches towards the identification of novel LOAD genes progresses.
- Genetic variants in periodontal health and disease 2010SpringerClassification of periodontal diseases -- Evidence for the role of genetic variants in periodontitis -- A gene mutation of major effect on human disease and its association with periodontitis -- Modifying disease genes in relation to periodontitis -- Heritability of chronic periodontitis -- Heritability of aggressive periodontitis -- Heritability of gingivitis -- Heritability of peri-implantitis -- Common guidelines for association studies -- Clinical utility of genetic knowledge.
- Part 1. Application and Perspectives -- ch. 1. Transgenic Modification of Production Traits in Farm Animals / Mathias Müller and Gottfried Brem -- ch. 2. Genetically Modified Plants / Susanne Stirn and Horst Lörz -- ch. 3. Fermented Food Production using Genetically Modified Yeast and Filamentous Fungi / Anke Niederhaus and Ulf Stahl -- ch. 4. Production of Food Additives using Filamentous Fungi / Carsten M. Hjort -- ch. 5. Perspectives of Genetic Engineering of Bacteria used in Food Fermentations / Arnold Geis -- Part II. Legislation in Europe -- ch. 6. The Legal Situation for Genetically Engineered Food in Europe / Rudolf Streinz and Lars O. Fuchs -- Part III. Methods of Detection -- ch. 7. Detection of Genetic Modifications: Some Basic Considerations / Knut J. Heller -- ch. 8. DNA-based Methods for Detection of Genetic Modifications / Ralf Einspanier and Stephanie Rief -- ch. 9. Genetic Engineering of Fishes and Methods for Detection / Hartmut Rehbein -- ch. 10. Detection Methods for Genetically Modified Crops / Rolf Meyer -- ch. 11. Methods to Detect the Application of Genetic Engineering in Composed and Processed Foods / Karl-Heinz Engel and Francisco Moreano -- ch. 12. Mutations in Lactococcus lactis, and their Detection / Jan Kok and Bertus van den Burg -- ch. 13. Detection Methods for Genetically Modified Microorganisms used in Food Fermentation / Walter P. Hammes, Christian Hertel and Torsten Bauer.
- Part I. Application and Perspectives -- ch. 1. Transgenic modification of production traits in farm animals / Gottfried Brem, Mathias Müller -- ch. 2. Genetically modified plants / Susanne Stirn, Horst Lörz -- ch. 3. Fermentation of food by means of genetically modified yeast and filamentous fungi / Rena Leisegang, Elke Nevoigt, Anja Spielvogel, Georg Kristan, Anke Niederhaus, Ulf Stahl -- ch. 4. Production of food additives using filamentous fungi / Carsten M. Hjort -- ch. 5. Genetic engineering of bacteria used in food fermentation / Arnold Geis -- Part II. Legislation in Europe -- ch. 6. The Legal situation for genetically engineered food in Europe / Rudolf Streinz, Jan Kalbheim -- Part III. Methods of Detection -- ch. 7. Detection of genetic modifications : some basic considerations / Knut J. Heller -- ch. 8. DNA-based methods for detection of genetic modifications / Ralf Einspanier -- ch. 9. Genetic engineering of fish, and methods of detection / Hartmut Rehbein -- ch. 10. Detection methods for genetically modified crops / Rolf Meyer -- ch. 11. Methods for detection of genetically modified organisms in composite and processed foods / Karl-Heinz Engel, Francisco Moreano, Alexandra Ehlert -- ch. 12. Mutations in Lactococcus lactis and their detection / Jan Kok, Bertus van den Burg -- ch. 13. Methods for detection of genetically modified microorganisms used in food fermentation processes / Walter P. Hammes, Christian Hertel, Torsten Bauer.
- Genetically engineered mice for cancer research design, analysis, pathways, validation and pre-clinical testing 2012SpringerOverview of designing genetically engineered mouse (GEM) models -- Use of Cre-loxP technology and inducible systems to generate mouse models of cancer -- Using recombineering technology to create genetically engineered mouse models -- Insertional mutagenesis for generating mouse models of cancer -- RCAS/TVA somatic gene transfer method in modeling human cancer -- Target-selected ENU mutagenesis to develop cancer models in the rat -- Tumor pathology of genetically engineered mice: genomic pathology -- Genomic DNA copy number alterations in mouse cancer models and human cancer -- Characterization of chromosomal translocations in mouse models of hematological malignancies using spectral karyotyping, FISH, and immunocytochemistry -- Expression profiling of mouse models of human cancer: model categorization and guidance for preclinical testing -- Imaging mouse models of human cancer -- Identifying mammary epithelial stem and progenitor cells -- Differentiation programs in development and cancer -- Roles of p53 and pRB tumor suppressor networks in human cancer: insight from studies in the engineered mouse -- Mouse models for colorectal cancer -- Src family tyrosine kinases: implications for mammary tumor progression -- Maspin and suppresion of tumor metastasis -- Epigenetic mouse models -- Modeling transforming growth factor-ss signalling in cancer -- Modeling stromal-epithelial interactions -- Utilizing mouse models of human cancer for assessing immune modulation of cancer development -- Transplanted tumor models for preclinical drug testing and the potential benefit of genetically engineered mouse models -- Development and use of genetically tractable preclinical mouse models -- Animal models for breast cancer prevention research -- Oncogene addiction: mouse models and clinical relevance for molecularly targeted therapies -- Mouse models in preclinical drug development: applications to CNS models -- Mouse models of human cancer: role in preclinical testing and personalized medicine -- Mighty, bow how useful? The emerging role of genetically engineered mice in cancer drug discovery and development.
- Genetically engineered mice handbook 2006CRCnetBASE
- Genetically modified organisms : concepts and methods -- Restriction enzymes : from their discovery to their applications -- Transforming growth factor-beta superfamily : animal models for development and disease -- Transfection of human neuroblastoma cells with Alzheimer's Disease brain hallmarks as a promising strategy to investigate the role of neurosteroidogenesis in neuroprotection -- Investigating therapeutic strategies for Fragile X syndrome in mice -- Innovative therapeutic perspectives in neuromuscular diseases -- Gene therapy for cancer treatment : state of the art -- Manipulating the mitochondrial genetic system.
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- Print MaterialGenes, genomes, and genetic analysis -- DNA structure and genetic variation -- Transmission genetics : the principle of segregation -- Chromosomes and sex-chromosome inheritance -- Genetic linkage and chromosome mapping -- Molecular biology of DNA replication and recombination -- Molecular organization of chromosomes -- Human karyotypes and chromosome behavior -- Genetics of bacteria and their viruses -- Molecular biology of gene expression -- Molecular mechanisms of gene regulation -- Genomics, proteomics, and transgenics -- Genetic control of development -- Molecular mechanisms of mutation and DNA repair -- Molecular genetics of the cell cycle and cancer -- Mitochondrial DNA and extranuclear inheritance -- Molecular evolution and population genetics -- The genetic basis of complex traits.
- Genetics and development of scoliosis 2010Springer
- Print Material"Genetics and Genomics in Medicine is a new textbook written for undergraduate and graduate students, as well as medical researchers, which explains the science behind the uses of genetics and genomics in medicine today. It is not just about rare inherited and chromosomal disorders, but how genetics affects the whole spectrum of human health and disease. DNA technologies are explained, with emphasis on the modern techniques that have revolutionized the use of genetic information in medicine and are indicating the role of genetics in common complex diseases. The detailed, integrative coverage of genetic approaches to treatment and prevention includes pharmacogenomics and the prospects for personalized medicine. Cancers are essentially genetic diseases and are given a dedicated chapter that includes new insights from cancer genome sequencing. Clinical disorders are covered throughout and there are extensive end-of-chapter questions and problems"--Provided by publisher.
- Genetics and molecular biology of neural tumors 2008Springer
- Genetics and randomness 2010CRCnetBASELimits and uncertainty in nature and logic -- Quantum fluctuations, mutations, and "fixation" of uncertainty -- Recombination and randomness -- Uncertainty of development -- Organized randomness -- Random genetic drift and "deterministic" selection -- Life : making uncertainty certain.
- Genetics and sports 2009KargerKey concepts in human genetics : understanding the complex phenotype / W.T. Gibson -- Nature versus nurture in determining athletic ability / T.D. Brutsaert, E.J. Parra -- Genetics and sports : an overview of the pre-molecular biology era / M.W. Peeters ... [et al.] -- Genes, athlete status, and training : an overview / I.I. Ahmetov, V.A. Rogozkin -- Angiotensin : converting enzyme, renin-angiotensin system and human performance / D. Woods -- Actinin-3 and performance / N. yang, F. Garton, K. North -- East African runners : their genetics, lifestyle, and athletic prowess / V.O. Onywera -- Gene-lifestyle interactions and their consequences on human health / J. Pomeroy, A.M. Söderberg, P.W. Franks -- Genetic risk factors for musculoskeletal soft tissue injuries / M. Collins, S.M. Raleigh -- Innovative strategies for treatment of soft tissue injuries in human and animal athletes / A. Hoffmann, G. Gross -- Gene doping : possibilities and practicalities / D.J. Wells -- Genetic testing of athletes / A.G. Williams, H. Wackerhage -- The future of genetic research in exercise science and sports medicine / R.J. Trent, B. Yu.
- Print MaterialWho am I? Genes and the problem of historical identity / Keith Wailoo -- Reconciliation projects : from kinship to justice / Alondra Nelson -- The unspoken significance of gender in constructing kinship, race, and nation / Catherine Lee -- A biologist's perspective on DNA and race in the genomics era / Abram Gabriel -- The dilemma of classification : the past in the present / Lundy Braun and Evelynn Hammonds -- The informationalization of race : communication, databases, and the digital coding of the genome / Peter A. Chow-White -- Forensic DNA phenotyping : continuity and change in the history of race, genetics, and policing / Pamela Sankar -- Forensic DNA and the inertial power of race in American legal practice / Jonathan Kahn -- Making history via DNA, making DNA from history : deconstructing the race-disease connection in admixture mapping / Ramya Rajagopalan and Joan H. Fujimura -- Waiting on the promise of prescribing precision : race in the era of pharmacogenomics / Sandra Soo-Jin Lee -- French families, paper facts : genetics, nation, and explanation / Nina Kohli-Laven -- Categorization, census, and multiculturalism : molecular politics and the material of nation / Amy Hinterberger -- "It's a living history, told by the real survivors of the times-DNA" : anthropological genetics in the tradition of biology as applied history / Marianne Sommer -- Cells, gene, and stories : HeLa's journey from labs to literature / Priscilla Wald -- The case of the genetic ancestor / Jennifer A. Hamilton -- Making sense of genetics, culture, and history : a case study of a native youth education program / Michelle M. Jacob -- Humanitarian DNA identification in post-apartheid South Africa / Jay D. Aronson -- Forbidden or forsaken? The (mis)use of a forbidden knowledge argument in research on race, DNA, and disease / Reanne Frank -- Genetic claims and credibility : revisiting history and remaking race / Keith Wailoo, Catherine Lee, and Alondra Nelson.
- Genetics for surgeons 2005NCBI Bookshelf
- Print MaterialGenetics: the study of biological information -- Mendel's breakthrough: patterns, particles, and principles of heredity -- Extensions to mendel: complexities in relating genotype to phenotype -- The chromosome theory of inheritance -- Linkage, recombination, and the the mapping of genes on chromosomes -- DNA: how the molecule of heredity carries, replicates, and recombines information -- Anatomy and function of a gene: dissection through mutation -- Gene expression: the flow of genetic information from DNA to RNA to protein -- Deconstructing the genome: DNA at high resolution -- Reconstructing the genome through genetic and molecular analysis -- The direct detection of genotype distinguishes individual genomes -- Systems biology and proteomics -- The eukaryotic chromosome: an organelle for packaging and managing DNA -- Chromosomal rearrangements and changes in chromosome number reshape eukaryotic genomes -- The prokaryotic chromosome: genetic analysis in bacteria -- The chromosomes of organelles outside the nucleus exhibit non-mendelian patterns of inheritance -- Gene regulation in prokaryotes -- Gene regulation in eukaryotes -- Cell-cycle regulation and the genetics of cancer -- Using genetics to study development -- The genetic analysis of populations and how they evolve -- Evolution at the molecular level.
- Genome-wide association studies in type 2 diabetes / Beer, N.L.; McCarthy, M.I. -- Fine mapping type 2 diabetes susceptibility loci / Morris, A.P. -- Whole genome and exome sequencing of type 2 diabetes / Gaulton, K.; Flannick, J.; Fuchsberger, C. -- Genome-wide association studies of glycaemic traits : a magical journey / Florez, J.C.; Barroso, I. -- Genome-wide association studies of obesity and related traits / Mohlke, K.L.; Lindgren, C.M. -- Next-generation sequencing for the diagnosis of monogenic diabetes and discovery of novel aetiologies / Ellard, S.; De Franco, E. -- Whole-exome sequencing of patients with severe disorders of insulin action / Semple, R.; Barroso, I. -- Epigenetic modifications and type 2 diabetes in humans / Ling, C. -- Insights into ?-cell biology and type 2 diabetes pathogenesis from studies of the islet transcriptome / van de Bunt, M.; Morán, I.; FerrerJ.; McCarthy, M.I. -- Genomics of adipose tissue / Pinnick, K.E.; Karpe, F. -- Translating genetic association signals for diabetes and metabolic traits into molecular mechanisms for disease / Rees, M.G.; Gloyn, A.L. -- Understanding molecular mechanisms for diabetes and obesity through mouse models / Merkestein, M.; Cox, R.; Ashcroft, F. -- Genetics of drug response in diabetes / Pearson, E.R.; Florez, J.C. -- Translating advances in our understanding of the genetics of diabetes into the clinic / Gardner, D.S.; Owen, K.R.; Gloyn, A.L.
- Genetics in ophthalmology 2003KargerA glimpse into genomeland / Langenbeck, U. -- Epidemiology of hereditary ocular disorders / Rosenberg, T. -- Interactions of genes and environment in myopia / Feldkämper, M., Schaeffel, F. -- A molecular perspective on corneal dystrophies / Vincent, A.L., Rootman, D., Munier, F.L., Héon, E. -- Molecular genetics of cataract / Hejtmancik, J.F., Smaoui, N. -- Progress in the genetics of glaucoma / Weisschuh, N., Schiefer U. -- LHON and other optic nerve atrophies: the mitochondrial connection / Howell, N. -- Retinitis pigmentosa: genes, proteins and prospects / Hims, M.M., Diager, S.P., Inglehearn, C.F. -- Bardet-Biedl syndrome and Usher syndrome / Koenig, R. -- Genetic defects in vitamin A metabolism of the retinal pigment epithelium / Thompson, D.A., Gal, A. -- Genetics of macular dystrophies and implications for age-related macular degeneration / Klaver, C.C.W., Allikmets, R. -- Genetics of color vision deficiencies / Deeb, S.S., Kohl, S. -- Gene therapy and animal models for retinal disease / Dejneka, N.S., Rex, T.S., Bennett, J. -- Support for patients loosing [sic] sight / Trauzettel-Klosinski, S., Hahn, G.0A. - Author index -- Subject index.
- Genetics of adaptation 2005Springer
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- Genetics of bacteria 2013SpringerDescribed as the earliest, simplest life forms, with unlimited metabolic versatility, bacteria are ideally suited to answer some very fundamental questions on life and its processes. They have been employed in almost all fields of biological studies, including Genetics. The whole edifice of science of Genetics centers around three processes: the generation, expression, and transmission of biological variation, and bacteria offer immediate advantages in studying all the three aspects of heredity. Being haploid and structurally simple, it becomes easy to isolate mutations of various kinds and relate them to a function. The availability of such mutants and their detailed genetic and biochemical analyses lead to a gamut of information on gene expression and its regulation. While studying the transmission of biological variation, it is clear that unlike their eukaryotic counterpart, a more genetic approach needs to be employed. Transmission of genetic information in most eukaryotic organisms rests on sexual reproduction that allows the generation of genetically variable offspring through the process of gene recombination. Even though bacteria show an apparent preference for asexual reproduction, they too have evolved mechanisms to trade their genetic material. In fact, bacteria not only could acquire many genes from close relatives, but also from entirely distant members through the process of horizontal gene transfer. Their success story of long evolutionary existence will stand testimony to these mechanisms. While teaching a course on Microbial Genetics to the post-graduate students at Delhi University, it was realized that a book devoted to bacterial genetics may be very handy to the students, researchers, and teachers alike. A strong foundation in genetics also helps in comprehending more modern concepts of molecular biology and recombinant DNA technology, always a favorite with the students and researchers. Planning the format of the book, emphasis has been laid on the generation and transmission of biological variability. The omission of expression part is indeed intentional because lots of information is available on this aspect in any modern biology book. The contents are spread over seven chapters and the text is supported with figures/tables wherever possible. The endeavor has been to induce the readers to appreciate the strength of bacterial genetics and realize the contribution of these tiny organisms to the growth of biological sciences as a whole and genetics in particular.
- Print MaterialThis book identifies and analyzes the genetic basis of bone disorders in humans and demonstrates the utility of mouse models in furthering the knowledge of mechanisms and evaluations of treatments. The book is aimed at all students of bone biology and genetics, and with this in mind, it includes general introductory chapters on genetics and bone biology and more specific disease-orientated chapters, which comprehensively summarize the clinical, genetic, molecular genetic, animal model, functional and molecular pathology, diagnostic, counselling and treatment aspects of each disorder. Saves academic, medical, and pharma researchers time in quickly accessing the very latest details on a broad range of genetic bone issues, as opposed to searching through thousands of journal articles. Provides a common language for bone biologists and geneticists to discuss the development of bone cells and genetics and their interactions in the development of disease. Researchers in all areas bone biology and genetics will gain insight into how clinical observations and practices can feed back into the research cycle and will, therefore, be able to develop more targeted genomic and proteomic assays. For those clinical researchers who are also MDs, correct diagnosis (and therefore correct treatment) of bone diseases depends on a strong understanding of the molecular basis for the disease.
- Genetics of colorectal cancer 2009Springer
- Genetics of epilepsy 2014ScienceDirect
- Genetics of male infertility 2007SpringerThe genetics of male infertility in the era of genomics: tools for progress / Douglas T. Carrell -- The use of cDNA libraries to demonstrate a linkage between transcription and translation in male germ cells / Norman B. Hecht -- Considerations when using array technologies for male factor assessment / Adrian E Platts, David J. Dix, and Stephen A. Krawetz -- Microarray analysis of a large number of single-nucleotide polymorphisms in individual human spermatozoa / Honghua Li ... [et al.] -- Physiological and proteomic approaches to understand human sperm function: prefertilization events / Sarah J. Conner -- Genetics of idiopathic male infertility: the power of a cross-species approach / Angshumoy Roy, Yi-Nan Lin, and Martin M. Matzuk -- The immunocytogenetics of human male meiosis: a progress report / Daniel Topping, Petrice Brown, and Terry Hassold -- The clinical relevance of sperm aneuploidy / Renee H. Martin -- DNA repair genes and genomic instability in severe male factor infertility / Francesca K.E. Gordon and Dolores J. Lamb -- Germ cell-specific genes and posttranscriptional regulation in the testis / Mark S. Fox and Renee A. Reijo Pera -- The genetics of cryptorchidism / Alexander I. Agoulnik and Shu Feng -- The chromatoid body and microRNA pathways in male germ cells / Martti Parvinen ... [et al.] -- Sperm maturation in the epididymis: role of segment-specific microenvironments / Gail A. Cornwall and Hans H. von Horsten -- The structure of the Y chromosome in infertility / Leslie Ayensu-Coker, Collin Bishop, and Jan Rohozinski -- Y chromosome microdeletions and haplotypes / Ken McElreavey ... [et al.] -- The genetics of male infertility: from bench to clinic / David M. de Kretser ... [et al.] -- The future of the diagnosis of male (in)fertility / Christopher De Jonge -- Polymorphisms and male infertility / Csilla Krausz -- The genetics of abnormal protamine expression / Vincent W. Aoki and Douglas T. Carrell -- Chromatin damage and male infertility / Denny Sakkas, Davide Bizzaro, and Gian C. Manicardi -- Clinical evaluation of the genetics of male infertility / Peter N. Schlegel.
- Genetics of mental retardation an overview encompassing learning disability and intellectual disability 2010KargerA parent's perspective / Gregory, J.P. -- Mental retardation : definition, classification, and etiology / Regan, R., Willatt, L. -- Technological advances in the molecular cytogenetic diagnosis of mental retardation : telomere testing and genome-wide array analysis / Kaminsky, E.B., Martin, C.L -- The importance of genome architecture in mental retardation / Mefford, H.C -- The clinical evaluation of patients with mental retardation/intellectual disability / Romano, C. -- Database aids for the evaluation of mental retardation / Firth, H.V. Carter, N.P. -- 3D shape and molecular analyses of facial dysmorphology associated with cognitive impairment / Hammond, P., Tassabehji, M. -- Monogenic causes of mental retardation / Raymond, F.L. -- Newly recognized mental retardation microdeletion/duplication syndromes -- Koolen, D.A., de Vries, B.B.A. -- Mendelian CNVs causing mental retardation and developmental disorders -- Vermeesch, J.R., de Ravel, T.J.L. -- Genetic overlaps in mental retardation, autism, and schizophrenia / Kooy, R.F. ... [et al.] -- Chromosome 22q13 rearrangements causing global developmental delay and autistic spectrum Disorder / Bonaglia, M.C. ... [et al.] -- Translating genetics research into a national health service clinical diagnostic environment / Taylor, J.
- Genetics of movement disorders 2003ScienceDirect
- Genetics of obesity 2014SpringerIn the past four years, many genetic loci have been implicated for BMI from the outcomes of genome-wide association studies (GWAS), primarily in adults. Insulin-induced gene 2 (INSIG2) was the first locus to be reported by this method to have a role in obesity, but replication attempts have yielded inconsistent outcomes. The identification of the second locus, the fat mass- and obesity-associated gene (FTO), has been more robustly observed by others. Studies from both FTO knock out and FTO over expression mouse model support the fact that FTO is directly involved in the regulation of energy intake and metabolism in mice, where the lack of FTO expression leads to leanness while enhanced expression of FTO leads to obesity. Along with numerous other studies, a number of genetic variants have been established robustly in the context of obesity, giving us fresh insights into the pathogenesis of the disease. This book provides a comprehensive overview of efforts aimed at uncovering genetic variants associated with obesity, which have been particularly successful in the past 5 years with the advent of genome-wide association studies (GWAS). The Genetics of Obesity covers this state of the art technology and its application to obesity in great detail. Topics include genetics of childhood obesity, genetics of syndromic obesity, copy number variants and extreme obesity, co-morbidities of obesity genetics, and functional follow-up of genetic variants.
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- Genital cutting protecting children from medical, cultural, and religious infringements; proceedings of the 11th International Symposium on Circumcision, Genital Integrity, and Human Rights, 29-31 July 2010, University of California-Berkeley 2013SpringerTortured Bodies, Tortured Doctrines: Informed Consent as a Legal Fiction Inapplicable to Neonatal Male Circumcision -- Routine Infant Circumcision: Vital Issues that the Circumcision Proponents may be Overlooking -- The Smart Penis -- The Harm of Circumcision -- Evolution of Circumcision Methods: Not "Just a Snip" -- Penile Wounding: Complications of Routine Male Circumcision in a Typical American Family Practice -- Male Circumcision and the Potential for Unexplained Male Adolescent Suicide in Northern Ireland -- Healing the Harms of Circumcision: A Nursing Case Study -- Ten Years of Training: Family Medicine Residents as Conscientious Objectors to Circumcision -- Intersex Surgeries, Circumcision, and the Making of "Normal" -- Intersex Genital Autonomy: A Rights-Based Framework for Medical Intervention with Intersex Infants -- The SAR/ROHAN (The Possession): A Response of Somali Women to Pharaonic Circumcision/Infibulation (PhC) -- Genital Stretching Among the Venda Ethnic Group (South Africa) -- Male Circumcision Among the Venda of Limpopo (South Africa) -- Critique of African RCTs into Male Circumcision and HIV Sexual Transmission -- Randomized Controlled Trials for HIV/AIDS Prevention Among Men in Africa: Untraced Infections, Unasked Questions, and Unreported Data -- Dangerous Myths and Tragic Misconceptions: Fighting HIV and AIDS Cases in Africa with Male Circumcision Strategies -- Defying the Enlightenment: Jewish Ethnicity and Ethnic Circumcision -- Circumcision: Gender and Power -- Reclaiming Circumcision: Armenian Stories -- Self-Made Intactivism in the Middle East -- Genital Autonomy: A New Approach.
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- Genitourinary imaging-- a case based approach 2015SpringerCovering all modalities currently used as well as emerging novel imaging tools, each chapter covers an aspect of Genitourinary Imaging with a comprehensive coverage of subspeciatlies. Genitourinary Imaging - A Case Based Approach closely mimics day to day clinical practice, and allows retention of pertinent practice information in an easy to understand format. Providing Genitourinary specific content in a portable form that can be used in close proximity to the PACS workstation, Genitourinary Imaging - A Case Based Approach is the perfect book for residents both in training and practicing as well as genitourinary radiologists worldwide.
- Genitourinary imaging-- case review. Third edition [3rd ed.]. 2016ClinicalKey
- Genitourinary imaging-- the requisites. Third edition [3rd ed.]. 2016ClinicalKeyAn introduction to radiologic methods -- The kidney and retroperitoneum : anatomy and congenital abnormalities / Raymond Dyer -- Renal masses / Ronald Zagoria -- The kidney : the diffuse parenchymal abnormality / Raymond Dyer -- The renal sinus, pelvocalyceal system, and ureter / Ronald Zagoria -- The lower urinary tract / Christopher Brady -- The female genital tract / Christopher Brady -- The male genital tract / Raymond Dyer -- Imaging of the adrenal glands / Christopher Brady -- Interventional genitourinary radiology / Ronald Zagoria.
- Genitourinary pathology-- practical advances 2015SpringerThis book provides a comprehensive, state-of-the art review of the genitourinary tumor pathology field and the most contemporary insights regarding specimen submission, histologic morphology, immunohistochemistry, and molecular studies useful in the diagnosis of genitourinary neoplasms. Discussion of the clinical implications of pathological findings is contributed by renowned clinicians in the field. This handsome volume guides the reader through the intricacies of genitourinary tumor pathology, diagnosis, reporting, and prognosis. Written by experts in the field, Genitourinary Pathology: Practical Advances is of great value to anatomic pathologists, urologists, fellows in genitourinary pathology, as well as upper level residents training in pathology .
- Genitourinary pathology. Second edition. [2nd ed.] 2015ClinicalKeyNonneoplastic diseases of the prostate / Kiril Trpkov -- Neoplastic diseases of the prostate / Ming Zhou, Cristina Magi-Galluzzi -- Nonneoplastic diseases of the urinary bladder / Fang-Ming Deng, Jonathan Melamed -- Neoplasms of the urinary bladder / Jesse K. McKenney, Ming Zhou, Cristina Magi-Galluzzi -- Nonneoplastic diseases of the kidney / Stephen M. Bonsib -- Neoplasms of the kidney / Ming Zhou, Eyas M. Hattab, John N. Eble, Liang Cheng -- Introduction to renal biopsy / Laura Barisoni, Lois J. Arend, David B. Thomas -- Diseases of the ureter and renal pelvis / Ximing J. Yang -- Diseases of penis, urethra, and scrotum / Rajal B. Shah -- Nonneoplastic diseases of the testis / Cristina Magi-Galluzzi, Howard S. Levin -- Neoplasms of the testis / Charles C. Guo.
- 1. Renal Neoplasms / Gregory T. MacLennan -- 2. Inflammatory Conditions of the Kidney / Gregory T. MacLennan -- 3. Cystic Diseases of the Kidney / Gregory T. MacLennan -- 4. Renal Calculus Disease / Can Zafer Karaman -- 5. Vascular Disorders of the Kidney / Gregory T. MacLennan -- 6. Medical Renal Disease and Transplantation Considerations / Gregory T. MacLennan -- 7. Non-neoplastic Disorders of the Renal Pelvis and Ureter / Gregory T. MacLennan -- 8. Neoplasms of the Renal Pelvis and Ureter / Gregory T. MacLennan -- 9. Renal and Ureteral Trauma / Vikram S. Dogra -- 10. Nonneoplastic Disorders of the Bladder / Gregory T. MacLennan -- 11. Neoplasms of the Bladder / Gregory T. MacLennan -- 12. Bladder Trauma / Musturay Karcaaltincaba -- 13. Congenital and Acquired Nonneoplastic Disorders of the Urethra / Gregory T. MacLennan -- 14. Neoplasms of the Urethra / Gregory T. MacLennan.
- Genitourinary radiology-- male genital tract, adrenal and retroperitoneum the pathologic basis 2013SpringerContrast Materials and Contrast Reaction Management -- Congenital and Acquired Nonneoplastic Disorders of the Prostate and Seminal Vesicles -- Neoplasms of the Prostate and Seminal Vesicles -- Congenital and Acquired Nonneoplastic Disorders of the Spermatic Cord and Testicular Adnexae -- Neoplasms of the Spermatic Cord and Testicular Adnexae -- Congenital and Acquired Nonneoplastic Disorders of the Testis -- Neoplasms of the Testis -- Congenital and Acquired Nonneoplastic Disorders of the Penis and Scrotum -- Neoplasms of the Penis and Scrotum -- Congenital and Acquired Nonneoplastic Adrenal Diseases -- Adrenal Neoplasms -- Congenital and Acquired Nonneoplastic Retroperitoneal Disorders -- Retroperitoneal Neoplasms -- Imaging of Urinary Diversion and Neobladder.
- Print MaterialDisorders of cornification -- Disorders of pigmentation -- Disorders of vascularization -- Disorders of connective tissue -- Disorders with malignant potential -- Epidermolysis bullosa -- Disorders of porphyrin metabolism -- Disorders with photosensitivity -- Disorders with immunodeficiency -- Disorders of hair and nails -- Disorders of metabolism -- Disorders with chromosome abnormalities -- Disorders with short stature.
- Print Materialv. 1. Analyzing DNA -- v. 2. Detecting genes -- v. 3. Cloning systems -- v. 4. Mapping genomes.
- Genome and disease 2006.KargerThe genomic basis of disease, mechanisms and assays for genomic disorders / P. Stankiewicz, J.R. Lupski -- Gross deletions and translocations in human genetic disease / S.S. Abeysinghe, N. Chuzhanova, D.N. Cooper -- Nucleotide excision repair and related human diseases / V. Bergoglio, T. Magnaldo -- Oxidative damage to DNA in non-malignant disease / M.D. Evans, M.S. Cooke -- Dominant non-coding repeat expansions in human disease / K.A. Dick ... [et al.] -- Telomeres and telomerase in stem cells during aging and disease / Z. Ju, K.L. Rudolph -- Retrotransposable elements and human disease / P.A. Callinan, M.A. Batzer -- The spindle checkpoint and chromosomal stability / W. Qi, H. Yu -- Protein kinases that regulate chromosome stability and their downstream targets / H. Nojima -- The role of the APC tumor suppressor in chromosomal instability / P. Alberici, R. Fodde -- c-Myc, genomic instability, and disease -- F. Kuttler, S. Mai -- Nijmegen breakage syndrome and functions of the responsible protein, NBS1 / A. Antoccia ... [et al.] -- Werner syndrome, aging, and cancer / A. Ozgenc, L.A. Loeb -- Fanconi anemia / R. Kalb ... [et al.].
- Genome dynamics and stability v. 1-, 2007-Springer
- Genome instability in cancer development 2005Springer
- Genome integrity facets and perspectives 2007SpringerFrom microorganisms to humans, this volume provides an interdisciplinary overview of how genome integrity is maintained. It begins with DNA replication and continues with replicative DNA repair and pleiotropic protein interactions. It also reviews the cellular responses to radiation and genotoxic stress affecting whole genomes.
- Genome mapping and genomics in arthropods 2008SpringerHoneybee / D. Schlipalius, P.R. Ebert, G.J. Hunt -- Bumblebee / L. Wilfert, P. Schmid-Hempel, J. Gadau -- The jewel wasp - Nasonia / J. Gadau ... [et al.] -- Silkworm / Y. Yasukochi, H. Fujii, M.R. Goldsmith -- Pea aphid / J.A. Brisson, G.K. Davis -- Mosquito / D.W. Severson -- Hessian fly / J.J. Stuart, M.-S. Chen, M.O. Harris -- Tick / A.J. Ullmann, J.J. Stuart, C.A. Hill.
- Genome mapping and genomics in laboratory animals 2012SpringerGenomics in the sea urchin : new perspectives on a perennial model system / Katherine M. Buckley amd Jonathan P. Rast -- Genome mapping and genomics of Caenorhabditis elegans / Jonathan Hodgkin, Michael Paulini, and mary Ann Tuli -- Genome mapping and genomics in Drosophila / Boris Adryan and Steven Russell -- Genome structure, functional genomics, and proteomics in ascidians / Yasunori Sasakura, Nicolas Sierro, Kenta Nakai, Kazuo Inaba, and takehiro G. Kusakabe -- Punching above their weight : the compact genomes of pufferfishes / Brian Cusack and Hugues Roest Crollius -- Medaka genomics and the methods and resources for decoding genomic functions / Tetsuaki Kimura, Yasuhiro Kamei, Yusuke Takehana, Takao Sasado, and Kiyoshi Naruse -- Xenopus genomics and genetics : progress and prospects / Amy K. Sater and Michael J. Gilchrist -- Mouse genome mapping and genomics / Paul Denny -- Rat genome mapping and genetics / Claude Szpirer and Göran Levan.
- Genome of Homo sapiens 2003Cold Spring Harb Lab PressHuman genome sequence -- Human genetic variation -- Genome structure and evolution -- Genomics of non-human species -- Bioinformatics and annotation -- Comparing genomes -- Comparative functional genomics -- Genetic variation and disease -- Genome biology and disease -- Human evolution.
- Genome stability and human diseases 2010SpringerComing full circle: Cyclin-dependent kinases as anti-cancer drug targets / R.P. Fisher -- Core and linker histone modifications involved in the DNA damage response / J.E. Chubb and S. Rea -- Chromatin assembly and signalling the end of DNA repair requires acetylation of histone H3 on lysine 56 / T. Costelloe and N.F. Lowndes -- Structure and function of histone H2AX / D.M. Pinto and A. Flaus -- The initiation step of eukaryotic DNA replication / H. Pospiech, F. Grosse and F.M. Pisani -- Non-coding RNAs: New players in the field of eukaryotic DNA replication / T. Krude -- Function of TopBP1 in Genome Stability / M. Sokka ... [et al.] -- Eukaryotic single-stranded DNA binding proteins: central factors in genome stability / S. Broderick ... [et al.] -- DNA polymerases and mutagenesis in human cancers / E. Crespan, A. Amoroso and G. Maga -- DNA polymerase [eta], a key protein in translesion synthesis in human cells / S. Cruet-Hennequart ... [et al.] -- The mitochondrial DNA polymerase in health and disease / W.C. Copeland -- Centromeres: assembling and propagating epigenetic function / M. Glynn ... [et al.] -- Nucleotide excision repair in higher eukaryotes: mechanism of primary damage recognition in global genome repair / N.I. Rechkunova and O.I. Lavrik -- Nonhomologous DNA end joining (NHEJ) and chromosomal translocations in humans / M.R. Lieber ... [et al.] -- Fluorescence-based quantification of pathway-specific DNA double-strand break repair activities: a powerful method for the analysis of genome destabilizing mechanisms / M. Bohringer and L. Wiesmuller -- Apoptosis: a way to maintain healthy individuals / C. Mondello and A.I. Scovassi -- The use of transgenic mice in cancer and genome stability research / S. Conmy and H.P. Nasheuer.
- Genome-wide association studies and genomic prediction 2013Springer Protocols"With the detailed genomic information that is now becoming available, we have a plethora of data that allows researchers to address questions in a variety of areas. Genome-wide association studies (GWAS) have become a vital approach to identify candidate regions associated with complex diseases in human medicine, production traits in agriculture, and variation in wild populations. Genomic prediction goes a step further, attempting to predict phenotypic variation in these traits from genomic information. Genome-Wide Association Studies and Genomic Prediction pulls together expert contributions to address this important area of study. The volume begins with a section covering the phenotypes of interest as well as design issues for GWAS, then moves on to discuss efficient computational methods to store and handle large datasets, quality control measures, phasing, haplotype inference, and imputation. Later chapters deal with statistical approaches to data analysis where the experimental objective is either to confirm the biology by identifying genomic regions associated to a trait or to use the data to make genomic predictions about a future phenotypic outcome (e.g. predict onset of disease). As part of the Methods in Molecular Biology series, chapters provide helpful, real-world implementation advice."--Back cover
- Introduction -- From genomes to protein functions -- Co-evolutionary signals within genome sequences reflect functional dependence of proteins -- Chromosomal proximity of genes as an indicator of functional linkage -- Analyses of complex genome-scale biological networks -- Application of protein interaction networks.
- Print MaterialGenomes, transcriptomes, and proteomes -- Studying DNA -- Mapping genomes -- Sequencing genomes -- Understanding a genome sequence -- Understanding how a genome functions -- Eukaryotic nuclear genomes -- Genomes of prokaryotes and eukaryotic organelles -- Virus genomes and mobile genetic elements -- Accessing the genome -- Assembly of the transcription initiation comple -- Synthesis and processing of RNA -- Synthesis and processing of the proteome -- Regulation of genome activity -- Genome replication -- Mutations and DNA repair -- Recombination -- How genomes evolve -- Molecular phylogenetics.
- Genomes and genomics of nitrogen-fixing organisms 2005Springer
- Genomes. 2nd ed. 2002NCBI Bookshelf
- Genomic and personalized medicine. 2nd ed. 2013ClinicalKeyThis two-volume set provides an in-depth look at one of the most promising avenues for advances in the diagnosis, prevention and treatment of human disease. The inclusion of the latest information on diagnostic testing, population screening, predicting disease susceptibility, pharmacogenomics and more presents this book as an essential tool for both students and specialists across many biological and medical disciplines, including human genetics and genomics, oncology, neuroscience, cardiology, infectious disease, molecular medicine, and biomedical science, as well as health policy disciplines focusing on ethical, legal, regulatory and economic aspects of genomics and medicine. Volume One Includes: Principles, Methodology and Translational Approaches, takes readers on the journey from principles of human genomics to technology, informatic and computational platforms for genomic medicine, as well as strategies for translating genomic discoveries into advances in personalized clinical care. Volume Two Includes: Genome Discoveries and Clinical Applications presents the latest developments in disease-based genomic and personalized medicine. With chapters dedicated to cardiovascular disease, oncology, inflammatory disease, metabolic disease, neuropsychiatric disease, and infectious disease, this work provides the most comprehensive guide to the principles and practice of genomic and personalized medicine. * Contributions from leaders in the field provide unparalleled insight into current technologies and applications in clinical medicine. * Full colour throughout enhances the utility of this work as the only available comprehensive reference for genomic and personalized medicine. * Discusses scientific foundations and practical applications of new discoveries, as well as ethical, legal/regulatory, and social issues related to the practice of genomic medicine.
- Genomic applications in pathology 2015SpringerGenomic Applications in Pathology provides a state-of-the art review of the scientific principles underlying next generation genomic technologies and the required bioinformatics approaches to analyses of the daunting amount of data generated by current and emerging genomic technologies. Implementation roadmaps for various clinical assays such as single gene, gene panels, whole exome and whole genome assays are discussed together with issues related to reporting, including the pathologist?s role in interpretation and clinical integration of genomic tests results. Genomic applications for site-specific solid tumors and hematologic neoplasms are detailed, as well as genomic applications in pharmacogenomics, inherited genetic diseases, and infectious diseases. The latest iteration of practice recommendations and guidelines in genomic testing, put forth by stakeholder professional organizations such as the Association for Molecular Pathology and the College of American Pathologists, are also discussed in the volume, as well as regulatory issues and laboratory accreditation related to genomic testing. Written by experts in the field, Genomic Applications in Pathology provides a comprehensive resource that is of great value to practicing molecular pathologists, hematopathologists, other subspecialized pathologists, general pathologists, pathology trainees, oncologists, and geneticists.
- Genomic approaches for cross-species extrapolation in toxicology proceedings from the Workshop on Emerging Molecular and Computational Approaches for Cross-Species Extrapolations, 18-22 July 2004, Portland, Oregon, USA 2007CRCnetBASE"Omics" approaches in the context of environmental toxicology / Jon C. Cook ... [et al.] -- Selection of surrogate animal species for comparative toxicogenomics / Nancy D. Denslow ... [et al.] -- Species differences in response to toxic substances: shared pathways of toxicity--value and limitations of omics technologies to elucidate mechanism or mode of action / David Eaton ... [et al.] -- Bioinformatic approaches and computational models for data integration and cross-species extrapolation in the postgenomic era / Kenneth S. Ramos ... [et al.] -- The extension of molecular and computational information to risk assessment and regulatory decision making / James S. Bus ... [et al.].
- Genomic biomarkers for pharmaceutical development advancing personalized health care 2014ScienceDirectGenomic Biomarkers for Pharmaceutical Development: Advancing Personalized Health Care provides an in-depth review of the state of translational science across all stages of pharmaceutical development with a special focus on personalized health care. This book provides a complete picture of biomarker development and validation in a pharmaceutical setting while addressing the inherent challenges of targeting the appropriate indications, biomarker robustness, regulatory hurdles, commercialization and much more. It features case studies devoted to the applications of pharmacogenomics, toxicogenomics, and other genetic technologies as they support drug discovery and development. With chapters written by international authorities in industry and academia, this work is a truly unique presentation of the thoughts and approaches that lead to the development of personalized medicine. Intended for all those involved in clinical translational research, this book is the ideal resource for scientists searching for the applications, strategies and successful approaches of translational science in pharmaceutical development. Provides case studies in applications of pharmacodynamic and predictive markers in drug development in oncology, autoimmunity, respiratory diseases and infectious diseases. Shows how to identify potential new therapeutic targets in different diseases and provides examples of potential new disease indications for life cycle management of drugs. Authored by leading international experts from industry and academia.
- Genomic disorders the genomic basis of disease 2006SpringerThe CMT1A duplication: a historical perspective viewed from two sides of an ocean / James R. Lupski and Vincent Timmerman -- Alu elements / Prescott Deininger -- The impact of LINE-1 retrotransposition on the human genome / Amy E. Hulme ... [et al.] -- Ancient transposable elements, processed pseudogenes, and endogenous retroviruses / Adam Pavlicek and Jerzy Jurka -- Segmental duplications / Andrew J. Sharp and Evan E. Eichler -- Non-B DNA and chromosomal rearrangements / Albino Bacolla and Robert D. Wells -- Genetic basis of olfactory deficits / Idan Menashe, Ester Feldmesser, and Doron Lancet -- Genomic organization and function of human centromeres / Huntington F. Willard and M. Katharine Rudd -- Primate chromosome evolution / Stefan Müller -- Genome plasticity in evolution: the centromere repositioning / Mariano Rocchi and Nicoletta Archidiacono -- The CMT1A duplication and HNPP deletion / Vincent Timmerman and James R. Lupski -- Smith-Magenis syndrome deletion, reciprocal duplication dup(17)(p11.2p11.2), and other proximal 17p rearrangements / Paweł Stankiewicz, Weimin Bi, and James R. Lupski -- Chromosome 22q11.2 rearrangement disorders / Bernice E. Morrow -- Neurofibromatosis 1 / Karen Stephens -- Williams-Beuren syndrome / Stephen W. Scherer and Lucy R. Osborne -- Sotos syndrome / Naohiro Kurotaki and Naomichi Matsumoto -- X chromosome rearrangements / Pauline H. Yen -- Pelizaeus-Merzbacher disease and spastic paraplegia type 2 / Ken Inoue -- Y-chromosomal rearrangements and azoospermia / Matthew E. Hurles and Chris Tyler-Smith -- Inversion chromosomes / Orsetta Zuffardi ... [et al.] -- Monosomy 1p36 as a model for the molecular basis of terminal deletions / Blake C. Ballif and Lisa G. Shaffer -- Inv dup(15) and inv dup(22) / Heather E. McDermid and Rachel Wevrick -- Mechanisms underlying neoplasia-associated genomic rearrangements / Thoas Fioretos -- Recombination hotspots in nonallelic homologous recombination / Matthew E. Hurles and James R. Lupski -- Position effects / Paweł Stankiewicz -- Chromosome-engineered mouse models / Pentao Liu -- Array-CGH for the analysis of constitutional genomic rearrangements / Nigel P. Carter ... [et al.] -- Appendix A: Well-characterized rearrangement-based diseases and genome structural features at the locus / Paweł Stankiewicz and James R. Lupski -- Appendix B: Diagnostic potential for chromosome microarray analysis / Paweł Stankiewicz, Sau W. Cheung and Arthur L. Beaudet.
- Genomic imprinting 2008SpringerDNA methylation reprogramming in the germ line / Diane J. Lees-Murdock and Colum P. Walsh -- Control of imprinting at the GNAS cluster / Jo Peters and Christine M. Williamson -- The GNAS locus and pseudohypoparathyroidism / Murat Bastepe -- Imprinted genes, postnatal adaptations, and enduring effects on energy homeostasis / Margalida Frontera ... [et al.] -- What are imprinted genes doing in the brain? / William Davies ... [et al.] -- Genomic imprinting and human psychology : cognition, behavior, and pathology / Lisa M. Goos and Gillian Ragsdale -- Genomic imprinting in plants / Olivier Garnier, Sylvia Laouiellé-Duprat, and Charles Spillane -- Imprinted genes and human disease : an evolutionary perspective / Francisco Úbeda and Jon F. Wilkins -- Evolutionary theories of imprinting ; enough already! / Tom Moore and Walter Mills.
- Genomic imprinting methods and protocolsSpringer ProtocolsGeneration of monoparental embryos for investigation into genomic imprinting -- Deriving and propagating mouse embryonic stem cell lines for studying genomic imprinting -- Balanced translocation for the analysis of imprinted regions of the mouse genome -- Production of YAC transgenic mice by pronuclear injection -- A transgenic approach to studying imprinted genes: modified BACs and PACs -- Methylation-sensitive genome scanning -- Subtraction-hybridization method for the identification of imprinted genes -- Identification of imprinted loci by methylation: use of methylation-sensitive representational difference analys (Me-RDA) -- Ribonuclease protection -- Quantitative RT-PCR-based analysis of allele-specific gene expression -- Allele-specific In Situ hybridization (ASISH) -- RNA-FISH to analyze allele-specific expression -- Flow cytometry and FISH to investigate allele-specific replication timing and homologous association of imprinted chromosomes -- Southern analysis using methyl-sensitive restriction enzymes -- A PCR-based method for studying DNA methylation -- Bisulfite-based methylation analysis of imprinted genes -- Direct analysis of chromosome methylation -- In vitro methylation of predetermined regions in recombinant DNA constructs -- In vitro methylation of specific regions in recombinant DNA constructs by excision and religation -- Probing chromatin, structure with nuclease sensitivity assays -- Examining histone acetylation at specific genomic regions -- Purification of the MeCP2/histone deacetylase complex from Xenopus laevis -- Reconstitution of chromatin in vitro -- Genomic imprinting in plants.
- Genomic instability and cancer metastasis mechanisms, emerging themes, and novel therapeutic strategies 2015SpringerMetastasis is the primary cause of mortality associated with cancer, and tumor genomic heterogeneity is a likely source for the cells that support cancer progression, resistance to therapy, and disease relapse. This book connects cancer metastasis with genomic instability in a comprehensive manner. Section 1 outlines the fundamental mechanisms responsible for these cellular and tissue phenotypes. Section 2 discusses in silico, in vitro, and in vivo models used for the experimental study of these processes. Section 3 reviews emerging themes (ex., microenvironment, mechanotransduction, and immunomodulation), and Section 4 highlights new therapeutic approaches to overcome the unique challenges presented by the heterogeneous and metastatic tumor. This book is intended for undergraduates and postgraduates with an interest in the areas of medicine, oncology, and cancer biology as well as for the content expert searching for thorough reviews of current knowledge in these areas.
- Genomic regulatory systems development and evolution 2001ScienceDirect
- Making the genome public : the American Museum of Natural History and the coming age of genomics / Michael Yudell and Rob DeSalle -- Genome science and the new frontier -- Introduction / Nicholas Wade -- What does knowing about genomes mean for science and society? / Harold Varmus -- Sequencing the human genome : elucidating our genetic blueprint / Eric Green -- Whole-genome shotgun sequencing / J. Craig Venter -- After the genome: where should we go? / Leroy Hood -- Applications of genomics to medicine and agriculture -- Introduction / Robert Bazell -- Genomics : a rapid road from gene to patient / William Haseltine -- The origins of cancer and the human genome / Arnold J. Levine -- Gene diversity in the endorphin system: SNPs, chips, and possible implications / Mary Jeanne Kreek -- Genomics and biotechnology in agriculture / Barbara A. Schaal -- Exploring human variation : understanding identity in the genomic era -- Introduction / Rob DeSalle -- Using maternal and paternal genes to unlock human history / Douglas C. Wallace -- Eugenics, the genome, and human rights / Daniel J. Kevles -- Redesigning the self: the promise and perils of genetic enhancement / David J. Rothman and Sheila M. Rothman -- Financial, legal, and ethical issues and the new genomics -- Introduction / Michael Waldholz -- Investing in the biotechnology sector / Kris H. Jenner -- The role of patents in exploiting the genome / Rebecca Eisenberg -- Social side effects of the new human molecular genetic diagnostics / Troy Duster -- Mapping morality : the rights and wrongs of genomics / Arthur l. Caplan -- Summing up : finding our way through the revolution / Kathi E. Hanna.
- Print MaterialFrom genes to genomes: a historical perspective -- The human genome: structure and organization -- Human function genomics and proteomics -- Epigenomics and human disease -- Genomic perspectives of human development -- Genetic and genomic approaches to taxonomy of human disease -- Genomic technologies -- Nutritional genomics -- Pharmacogenomics: drug development, drug response, and precision medicines -- Clinical medicine in the genome era: an introduction -- Complex cardiovascular disorders -- Diabetes mellitus and obesity -- Chronic renal disease -- Hemostasis and thrombosis -- Disorders of platelets -- Applications in critical care medicine -- The epilepsies -- Neurodegenerative disorders: tauopathies and synucleinopathies -- Neuropsychiatric diseases I: schizophrenia -- Neuropsychiatric disease II: mood disorders -- Asthma and chronic obstructive pulmonary disease -- Inflammatory bowel disease -- Genomics and cancer: mechanisms and applications -- Hematological malignancies: the paradigm of acute myeloid leukemia -- Genomics and infectious diseases: susceptibility, resistance, antimicrobial therapy -- Rheumatoid arthritis and related arthropathies -- Immunological disorders -- Applications in clinical pediatrics -- Learning and behavioral disorders -- Complex ophthalmic disorders -- Applications in audiological medicine -- Complex skin diseases I: psoriasis -- Complex skin diseases II: atopic dermatitis -- Diseases of the epidermis and appendages, skin pigmentation and skin cancer -- Osteoporosis and disorders -- Applications in obstetrics and gynecology and reproductive medicine -- Stem cell genomics, and regenerative medicine -- Genomics and global health -- Genetic testing and genomic screening -- Ethical, legal, and social issues (ELSI) -- The regulation of human genomics research.
- Genomic experimental approaches in oncology -- Pharmacogenomics of toxicity and response of chemotherapy -- Pharmacogenomics in clinical drug development in oncology.
- This book offers a valuable resource that allows students, researchers, educators and the general public to learn about proteomics and genomics. Chromosomes form the basis for our genetic heritage and are the code for protein synthesis. The Human Genome Map was presented in 2002, and the Proteome Sequence Map is currently being created by a global consortia initiative. Proteome and genome building blocks already form the basis of scientific research areas and shape major areas of the pharmaceutical and biomedical industries. The book provides background information on and our current understanding of these gene and protein areas, and explains in detail how cutting-edge science is using these resources to develop new medicines and new diagnostics for patient treatment and care. The book will benefit all students and researchers who need a good understanding of genomics and proteomics within the clinical field. Its content is also suitable for a broad readership, including those not specialized in this field. Dr. Marko-Varga is head of Div. Clinical Protein Science & Imaging at the Biomedical Center, Dept. of Measurement Technology and Industrial Electrical Engineering, Lund University. He's also Professor at the 1st Department of Surgery, Tokyo Medical University, Tokyo, Japan.
- Microarray-based gene expression analysis of endocrine systems: principles of experimental design and interpretation. -- Gene expression profiles and transcription factors involved in parathyroid hormone signaling in osteoblastic cells. -- Analysis of growth hormone effects on hepatic gene expression in hypophysectomized rats. -- Gene expression profiling in leiomyoma in response to GnRH therapy and TGF-beta. -- Gene profiling analysis of androgen receptor mediated function. -- Interrogating estrogen receptor [alpha] signaling in breast cancer by chromatin immunoprecipitation microarrays. -- Gene expression analysis of the adrenal cortex in health and disease. -- DNA microarray analysis of human uterine decidualization. -- Large-scale DNA microarray data analysis reveals glucocorticoid receptor-mediated breast cancer cell survival pathways. -- Application of microarrays for gene transcript analysis in type 2 diabetes. -- DNA microarray analysis of effects of TSH, iodide, cytokines, and therapeutic agents on gene expression in cultured human thyroid follicles. -- Genomics and polycystic ovary syndrome (PCOS): the use of microarray analysis to identify new candidate genes. -- Microarray analysis of alterations induced by obesity in white adipose tissue gene expression profiling. -- Novel molecular signaling and classification of human clinically nonfunctioning pituitary adenomas identified by microarray and reverse transcription-quantitative polymerase chain reaction. -- Gene expression studies of prostate hyperplasia in prolactin transgenic mice.
- Toxicogenomics in ecological risk assessments: regulatory context, technical background, and workshop overview / Gerald Ankley, Ann Miracle, and Edward Perkins -- Application of genomics to screening / Sean W. Kennedy ... [et al.] -- Application of genomics to tiered testing / Charles R. Tyler ... [et al.] -- Application of genomics to regulatory ecological risk assessments for pesticides / Sigmund J. Degitz ... [et al.] -- Application of genomics to assessment of the ecological risk of complex mixtures / Edward Perkins ... [et al.] -- Applications of genomic technologies to ecological risk assessments at remediation and restoration sites / Ann L. Miracle ... [et al.] -- Toxicogenomics in ecological risk assessments: a prospectus / George P. Daston ... [et al.]. Toxicogenomics in ecological risk assessments: regulatory context, technical background, and workshop overview / Gerald Ankley, Ann Miracle, and Edward Perkins -- The development of genomic-based screening assays for ecotoxicology / Sean W. Kennedy ... [et al.] -- Application of genomics to tiered testing / Charles R. Tyler ... [et al.] -- Application of genomics to regulatory ecological risk assessments for pesticides / Sigmund J. Degitz ... [et al.] -- Molecular biology and risk assessment: evaluation of the potential roles of genomics in regulatory ecotoxicology / Edward Perkins ... [et al.] -- Applications of genomic technologies to ecological risk assessments at remediation and restoration sites / Ann L. Miracle ... [et al.] -- Toxicogenomics in ecological risk assessments: a prospectus / George P. Daston ... [et al.].
- Genomics of disease 2008Springer
- Genomics of pattern recognition receptors applications in oncology and cardiovascular diseases 2013SpringerThe Biology of Toll-like Receptors and NOD-like Receptors: Toggles of Inflammation -- Pattern Recognition Receptors, Gene Polymorphisms, and Cancer: A Double-Edged Sword -- Structural Genomic Variation in Toll-Like Receptor 4 and Cancer -- Structural Genomic Variation in Other Toll-like Receptors and Cancer -- Structural Genomic Variation in Toll-Like Receptor Signaling Pathway and Cancer -- Structural Genomic Variation in Toll-like Receptor Pathway and Prostate Cancer -- Structural Genomic Variation in NOD-Like Receptors and Cancer -- Structural Genomic Variation in Pattern Recognition Receptors and Cardiovascular Diseases -- Hot Spots In the Field: Where Should We Go.
- Genomics protocols. 2nd ed. 2008Springer ProtocolsProtein profiling based on two-dimensional difference gel electrophoresis / Gert Van den Bergh and Lutgarde Arckens -- Quantitative protein profiling by mass spectrometry using isotope-coded affinity tags / Arsalan S. Haqqani, John F. Kelly, and Danica B. Stanimirovic -- Quantitative protein profiling by mass spectrometry using label-free proteomics / Arsala S. Haqqani, John F. Kelly, and Danica B. Stanimirovic -- Using 2D-LC-MS/MS to identify Francisella tularensis peptides in extracts from an infected mouse macrophage cell line / John F. Kelly and Wen Ding -- Baculovirus expression vector system : an emerging host for high-throughput eukaryotic protein expression / Binesh Shrestha, Carol Smee, and Opher Gileadi -- Coimmunoprecipitation and proteomic analyses / S. Fabio Falsone, Bernd Gesslbauer, and Andreas J. Kungl -- Tandem affinity purification combined with mass spectrometry to identify components of protein complexes / Peter Kaiser ... [et al.] -- Mammalian two-hybrid assay for detecting protein-protein interactioins in vivo / Runtao He and Xuguang Li -- Detection of protein-protein interactions in live cells and animals with split firefly luciferase protein fragment complementation / Victor Villalobos, Snehal Naik, and David Piwnica-Worms -- Subcellular localization of intracellular human proteins by construction of tagged fusion proteins and transient expression in COS-7 cells / John E. Collins -- GeneFAS : a tool for the prediction of gene function using multiple sources of data / Trupti Joshi ... [et al.] --Comparative genomics-based prediction of protein function / Toni Gabaldón -- Design, manufacture, and assay of the efficacy of siRNAs for gene silencing / Louise A. Dawson and Badar A. Usmani. Whole genome amplification with Phi29 DNA polymerase to enable genetic or genomic analysis of samples of low DNA yield / Kaisa Silander and Janna Saarela -- Scanning for DNA variants by denaturant capillary electrophoresis / Per O. Ekstrøm -- Identification of SNPs, or mutations in sequence chromatograms / Nicole Draper -- BeadArray-based genotyping / Helen Butler and Jiannis Ragoussis -- Microsattelite-based candidate gene linkage analysis studies / Cathryn Mellersh -- Full complexity genomic hybridization on 60-mer oligonucleotide microarrays for array comparative genomic hybridization (aCGH) / Alexei Protopopov, Bin Feng, and Lynda Chin -- Detection of copy number changes at multiple loci in DNA prepared from formalin-fixed, paraffin-embedded tissue by multiplex ligation -dependent probe amplification / Minoru Takata -- Application of microarrays for DNA methylation profiling / Axel Schumacher, Andreas Weinhäusl, and Arturas Petronis -- Genomewide identification of protein binding locations using chromatin immunoprecipitation coupled with microarray / Byung-Kwan Cho, Eric M. Knight, and Bernhard Ø. Palsson -- Transcriptional profiling of small samples in the central nervous system / Stephen D. Ginsberg -- Quantitative expression profiling of RNA from formalin-fixed, paraffin-embedded tissues using randomly assembled bead arrays / Marina Bibikova ... [et al.] -- Expression profiling of microRNAs in cancer cells : technical considerations / Mouldy Sioud and Lina Cekaite -- Identification of disease biomarkers by profiling of serum proteins using SELDI-TOF mass spectrometry / Sigrun Langbein -- The applicability of a cluster of differentiation monoclonal antibody microarray to the diagnosis of human disease / Peter Ellmark ... [et al.] --
- Genomics, proteomics, and the nervous system 2011SpringerComplex behaviours are the product of intercellular signalling events, but their intracellular effectors are present in most cell types. The best-studied example of such architecture is the circadian clock, which directs all diurnal behaviour and physiology, and whose central mechanism is present in most body cells. We present below a method to look at its properties via transcriptional reporters virally delivered to primary cells. By studying primary fibroblasts cultivated from skin biopsies in different human subjects, we have been able to analyse the molecular underpinnings of variance in human daily behaviour. Similar methodologies could be applied to other signalling pathways.
- Genotoxicity and DNA repair a practical approach 2014Springer ProtocolsGenotoxicity and DNA Repair: A Practical Approach provides a key reference for determining how to analyze the genotoxic activity of molecules or materials and, at the same time, serves as a useful tool for researchers in the Environmental Mutagenesis and DNA Repair fields. Focused on genotoxicity assays recommended by the "OECD guidelines for the testing of chemicals", this volume also covers other useful assays, such as some gene mutation assays, the comet assay in different species and applications, and the SMART assays of Drosophila. For all the assays, the book presents brief theoretical introductions to the topics and updated standard and modified step-by-step protocols to perform them. Special emphasis is placed on the analysis of nanoparticles, including an integrative approach analysis. The DNA Repair section includes several assays that provide information on repair activity in vitro and in vivo, as well as recent applications to study DNA repair in humans, cell cultures, and animal models. As a volume in the Methods in Pharmacology and Toxicology series, the chapters contain the kind of detail and key implementation advice that ensures reproducible results in the lab.
- Genotoxicity assessment methods and protocols 2013Springer ProtocolsGenetic toxicology is recognized by geneticists and researchers concerned with the genetic impact of man-made chemicals.In Genotoxicity Assessment: Methods and Protocols, expert researchers in the field provide comprehensive genetictoxicology protocols. These include in vitro and in vivo protocols on mutation assays, cytogenetic techniques, and primary DNA damage, assays in alternate to animal models, and updated ICH guidelines. Written in the highly successfulMethods in Molecular Biology series format, the chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, as well as key tips ontroubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Genotoxicity Assessment: Methods and Protocols seeks to aid research students and scientists working in regulatory toxicology as well as biomedical, biochemical and pharmaceutical sciences.
- Print Material
- Genus Yersinia from genomics to function 2007Springer"The 9th International Symposium on Yersinia was held in Lexington, Kentucky, USA on October 10-14, 2006. Over 250 Yersinia researchers from 18 countries gathered to present and discuss their research. In addition to 37 oral presentations, there were 150 poster presentations. This Symposium volume is based on selected presentations from the meeting and contains both reviews and research articles. It is divided into six topic areas: 1) genomics; 2) structure and metabolism; 3) regulatory mechanisms; 4) pathogenesis and host interactions; 5) molecular epidemiology and detection; and 6) vaccine and antimicrobial therapy development. Consequently, this volume covers a wide range of current research areas in the Yersinia field."--Preface.
- Geocoding health data the use of geographic codes in cancer prevention and control, research, and practice 2008CRCnetBASE
- Geomicrobiology. 4th ed., rev. and expanded. 2002CRCnetBASE
- Geranium and pelargonium the genera geranium and pelargonium 2002CRCnetBASE
- Geriatric anesthesiology. 2nd ed. 2008SpringerThe practice of geriatric anesthesia / Jeffrey H. Silverstein -- Demographics and economics of geriatric patient care / Maria F. Galati and Roger D. London -- Theories of aging / Stanley Muravchick -- Ethical management of the elderly patient / Paul J. Hoehner -- Teaching geriatric anesthesiology to practitioners, residents, and medical students / Sheila J. Ellis -- Research priorities in geriatric anesthesiology / Christopher J. Jankowski and David J. Cook -- Alterations in metabolic functions and electrolytes / Michael C. Lewis -- Perioperative thermoregulation / Daniel I. Sessler -- Postoperative central nervous system dysfunction / Deborah J. Culley, Terri G. Monk, and Gregory Crosby-- Alterations in circulatory function / Thomas J. Ebert and G. Alec Rooke -- The aging respiratory system : anesthetic strategies to minimize perioperative pulmonary complications / Rodrigo Cartin-Ceba ... [et al.] -- Operative debridements of chronic wounds / Andrew M. Hanflik ... [et al.] -- Preoperative risk stratificationand methods to reduce risk / Linda L. Liu and Jacqueline M. Leung -- Anesthetic implications of chronic medications / Tamas A. Szabo and R. David Warters -- The pharmacology of opioids / Steven L. Shafer and Pamela Flood -- Intravenous hypnotic anesthetics / Matthew D. McEvoy and J.G. Reves -- Inhalational anesthetics / Gary R. Haynes -- Relaxants and their reversal agents / Cynthia A. Lien and Takahiro Suzuki -- Management of regional anesthesia / Bernadette Veering -- Fluid management / Jessica Miller, Lee A. Fleisher, and Jeffrey L. Carson -- Pain management / Jack M. Berger -- Anesthesia considerations for geriatric outpatients / Kathryn E. McGoldrick -- Sedaton and monitoring / Sheila R. Barnett -- Total hip replacement, joint replacement, and hip fracture / Idit Matot and Shaul Beyth -- Transurethral prostatectomy syndrome and other complications of urologic procedures / Daniel M. Gainsburg -- Thoracic procedures / Steven M. Neustein and James B. Eisenkraft -- Cardiac procedures / James H. Abernathy III -- Vascular procedures / Leanne Groban and Sylvia Y. Dolinski -- Abdominal procedures / Jeffrey H. Silverstein.
- Print Material
- Geriatric imaging 2013SpringerIn the elderly, the coexistence of various diseases, the presence of involutional and degenerative changes, and the occurrence of both physical and cognitive problems represent ""the norm."" It is therefore important to know how to distinguish the healthy elderly from those in need of treatment as a sound basis for avoiding overdiagnosis and overtreatment. This aspect is a central theme in Geriatric Imaging, which covers a wide range of applications of different imaging techniques and clearly explains both the potential and the limitations of diagnostic imaging in geriatric patients.
- Geriatric nutrition 2007CRCnetBASE1. The aging society and nutrition epidemiology / Shailaja Pulisetty and John E. Morley -- 2. Molecular theories of aging and nutritional interventions / H.J. Armbrecht -- 3. The role of nutrition in the prevention of age-associated diseases / John E. Morley -- 4. Obesity in older adults / Gary A. Wittert -- 5. Sarcopenia and cachexia / John E. Morley and Matthew T. Haren -- 6. Immunity and nutrition / Chantri Trinh -- 7. Nutritional requirements in older adults / David R. Thomas -- 8. Energy balance / John E. Morley -- 9. Water metabolism / David R. Thomas and John E. Morley -- 10. Vitamin disorders / Ramzi R. Hajjar and Zeina Nahhas -- 11. Trace elements / John E. Morley -- 12. Nutritional assessment in older persons / David R. Thomas -- 13. Geriatric assessment and its interaction with nutrition / Julie K. Gammack -- 14. Nutritional assessment in the European community / Juergen Martin Bauer and Dorothee Volkert -- 15. The oral cavity and nutrition / Nathalia Garcia and D. Douglas Miley -- 16. Management of protein-energy undernutrition in older adults / David R. Thomas -- 17. Prescription for enteral nutrition / Zareen Syed and Syed H. Tariq.
- Aging and cancer, what oncologists need to know / Arti Hurria, Lodovico Balducci -- Assessing the older cancer patient / Melissa Cohen, David Reuben, Arash Naeim -- Cancer screening in older adults / Louise C. Walter -- Physiological consequences of aging / Bindu Kanapuru, William B. Ershler -- Assessment and impact of comorbidity in older adults with cancer / Athanasios Karampeasiz, Martine Extermann -- Geriatric syndromes defined and explained for oncology practice / Miriam B. Rodin -- Family caregivers / Betty R. Ferrell, Polly Mazanec -- Surgical management of the older patient with cancer / David M. Heimann, M. Margaret Kemeny -- Chemotherapy for the older adult with cancer / Supriya Mohile, Nail Nagovskiy, Lodovico Balducci -- Radiation therapy in geriatric oncology / Sarah E. Hoffe, Mark S. Russell -- Palliative care, special considerations for older adults with cancer / Genevieve N. Thompson, Harvey M. Chochinov.
- Geriatric ophthalmology a competency-based approach 2009SpringerScope of the problem and demographic shift in population: visual disease incidence and prevalence in the elderly population -- Refractive error in the geriatric population -- Cataracts and cataract surgery -- Glaucoma in the elderly -- Diabetic retinopathy and its management -- Age-related macular degeneration and its management -- Low vision: when vision fails -- Visual loss and depression -- Visual loss and dementia -- Visual loss and hearing loss -- Visual loss and falls -- Elder abuse -- Functional impairment and visual loss -- The research agenda-setting project (RASP) -- Screening for comorbidities -- Refer comorbidities.
- Geriatric otolaryngology 2015Thieme-ConnectThe science of aging / Alessandro Bitto, Chad A. Lerner, and Christian Sell -- Geriatric otolaryngology : an overview / Karen M. Kost -- Understanding geriatric syndromes, the geriatric interdisciplinary team, and resources to optimize care for older patients / Sarah H. Kagan -- Evaluation of the outpatient geriatric patient / David Eibling -- Operative evaluation of the geriatric patient / Natalie Justicz and Jeanne Hatcher -- Age-related hearing loss / Kourosh Parham, Frank R. Lin, and Brian W. Blakley -- Regenerative therapies for sensorineural hearing loss : current research implications for future treatment / Cynthia L. Chow and Samuel P. Gubbels -- Hearing aids : considerations in the geriatric population / Amanda Kantor, Erica Miele, John Luckhurst, Mary Hawkshaw, and Robert T. Sataloff -- Cochlear implantation in the elderly / Daniel H. Coelho and Brian J. McKinnon -- Subjective idiopathic tinnitus in the geriatric population / Paul F. Shea and Brian J. McKinnon -- Dizziness, imbalance, and age-related vestibular loss in the geriatric population / Yuri Agrawal, Allan Rubin, and Stephen J. Wetmore -- Sinonasal disease in the elderly / David R. Edelstein -- Taste and smell in the elderly / Richard L. Doty and Hussam Tallab -- Inhalant allergies and asthma in the geriatric population / Karen H. Calhoun -- Voice disorders in the elderly / Robert T. Sataloff and Karen M. Kost -- Swallowing disorders in the elderly / Ozlem E. Tulunay-Ugur -- Sleep disturbance in the geriatric population / Christopher G. Larsen and M. Boyd Gillespie -- Facial plastic surgery in geriatric patients / J. Regan Thomas -- Oral cavity disorders in geriatric patients / Elliot Regenbogen and Denise A. Trochesset -- Advanced cutaneous malignancies in the elderly / Kelly Michele Malloy and Chaz L. Stucken -- Head and neck cancer in the elderly / Mihir R. Patel, Raymond L. Chai, and Ara A. Chalian -- The role of neuropsychology in the evaluation and treatment of geriatric patients / Thomas Swirsky-Sacchetti and Caterina B. Mosti.
- Geriatric physical therapy. 3rd ed. 2012ScienceDirectGeriatric Physical Therapy offers a comprehensive presentation of geriatric physical therapy science and practice. Thoroughly revised and updated, editors Andrew Guccione, Rita Wong, and Dale Avers and their contributors provide current information on aging-related changes in function, the impact of these changes on patient examination and evaluation, and intervention approaches that maximize optimal aging. Chapters emphasize evidence-based content that clinicians can use throughout the patient management process. Six new chapters include: Exercise Prescription, Older Adults and Their Families, Impaired Joint Mobility, Impaired Motor Control, Home-based Service Delivery, and Hospice and End of Life. Clinically accurate and relevant while at the same time exploring theory and rationale for evidence-based practice, it's perfect for students and practicing clinicians. It's also an excellent study aid for the Geriatric Physical Therapy Specialization exam. Comprehensive coverage provides all the foundational knowledge needed for effective management of geriatric disorders. Content is written and reviewed by leading experts in the field to ensure information is authoritative, comprehensive, current, and clinically accurate. A highly readable writing style and consistent organization make it easy to understand difficult concepts. Tables and boxes organize and summarize important information and highlight key points for quick reference. A well-referenced and scientific approach provides the depth to understand processes and procedures. Theory mixed with real case examples show how concepts apply to practice and help you enhance clinical decision-making skills. Standard APTA terminology familiarizes you with terms used in practice.
- Geriatric rheumatology a comprehensive approach 2011SpringerPart 1. Aging and Comorbidity in Rheumatology -- The Immune System in Aging / Anjali Desai and Raymond L. Yung -- Bone Aging / Arthur N. Lau and Jonathan D. Adachi -- Atherosclerosis in the Rheumatic Diseases: Compounding the Age Risk / Naoto Yokogawa and Joan M. Von Feldt -- Neuropsychiatric Manifestations of Rheumatic Diseases in the Elderly / Jamal A. Mikdashi -- Tuberculosis and Rheumatoid Arthritis in the Elderly / Eduardo M. Acevedo-Vásquez, Darío Ponce de León and Rocío V. Gamboa-Cárdenas -- Widespread Pain in Older Adults / Cheryl D. Bernstein, Jordan F. Karp and Debra K. Weiner -- Part 2. Multidisciplinary Approach to Geriatric Rheumatology -- Pharmacotherapy Considerations Unique to the Older Patient / Keith A. Swanson and Mark A. Stratton -- Rheumatic Disease in the Nursing Home Patient / Joanne Sandberg-Cook -- Post-acute Care for Rheumatologists / Deborah W. Robin -- The Gerontorheumatology Outpatient Service: Toward an International Classification of Function-Based Health Care Provision for the Elderly with Musculoskeletal Conditions / Wim Van Lankveld, Josien Goossens and Marcel Franssen -- Health Policy, Public Health, and Arthritis Among Older Adults / Kristina A. Theis, Debra R. Lubar and Teresa J. Brady -- Physical Therapy Management of Select Rheumatic Conditions in Older Adults / Maura Daly Iversen and Madhuri K. Kale -- Arthrocentesis in the Elderly / Ahmed S. Zayat and Richard J. Wakefield -- Physical Activity in Older Adults with Arthritis / Dorothy D. Dunlop, Pamela A. Semanik and Rowland W. Chang -- Part 3. Rheumatic Diseases in the Elderly -- Systemic Lupus Erythematosus in Elderly Populations / Ana M. Bertoli, Guillermo J. Pons-Estel, Paula I. Burgos and Graciela S. Alarcón -- Elderly Onset Rheumatoid Arthritis / Venkata Sri Cherukumilli and Arthur Kavanaugh -- Disease-Modifying Antirheumatic Drug Use in Older Rheumatoid Arthritis Patients / Sogol S. Amjadi, Veena K. Ranganath and Daniel E. Furst -- Epidemiology, Risk Factors, and Aging of Osteoarthritis / Crisostomo Bialog and Anthony M. Reginato -- Osteoarthritis in the Elderly Population / Roy D. Altman -- Medium- and Small-Vessel Vasculitis / Rafael G. Grau -- Management of Geriatric Gout / Lan X. Chen -- Calcium-Containing Crystal-Associated Arthropathies in the Elderly Population / Elisabeth B. Matson and Anthony M. Reginato -- Polymyalgia Rheumatica and Giant Cell Arteritis in the Elderly / Wolfgang A. Schmidt -- Antiphospholipid Syndrome in the Older Population / Silvia S. Pierangeli, Alan M. Seif and Emilio B. González -- Osteoporosis and Metabolic Bone Diseases of the Elderly / Lora Giangregorio and Alexandra Papaioannou -- Infectious Arthritis in the Elderly / Nicole Melendez and Luis R. Espinoza -- Sarcopenia and Myopathies in the Elderly / Kenneth S. O'Rourke -- Scleroderma in the Elderly Population / Rebecca L. Manno and Fredrick M. Wigley -- Sjögren's Syndrome in the Elderly / Raymond L. Yung and Sheeja Francis.
- Geriatric trauma and critical care 2014SpringerGeriatric Trauma and Critical Care provides a multidisciplinary overview of the assessment and management of the elderly patient presenting with surgical pathology. By utilizing current literature and evidence-based resources, the textbook elucidates the unique nature of caring for the elderly population. The structure of the volume provides the reader with an overview of the physiologic and psychological changes, as well as the impact on the healthcare system, associated with the aging process. Emphasis is placed on the impact of aging, pre-existing medical problems, effects of polypharmacy, advanced directives and end-of-life wishes on acute surgical problems, including trauma and surgical critical care. Special attention is given to the ethical implications of management of the aged. The multidisciplinary contributors provide a unique point of view not common to surgical texts. The textbook is the definitive resource for practicing surgeons, emergency medicine physicians, intensivists, anesthesiologists, hospitalists, geriatricians, as well as surgical residents, nurses and therapists, all who care for elderly patients with surgical emergencies.
- Geriatric urology 2014SpringerGeriatric urology represents one of the largest overall sectors of care provided within the specialty of urology. As the incidence and prevalence of many clinical urologic conditions increase significantly in older adults, the practice of urology involves a need for advanced knowledge of the basic principles of geriatrics. Geriatric Urology outlines important topics in the care of elderly urology patients. The first section covers the biology of aging, changes in the genitourinary system, and common diseases including urologic conditions that may serve as warning signs of other disorders. Section two covers geriatric syndromes and implications for urologic care including frailty, polypharmacy, dementia, , and wound healing. Urologic conditions in older adults are explored in detail including urinary incontinence, pelvic organ prolapse, urinary tract infection, nocturia, and benign prostate diseases. Other topics covered include obtaining informed consent, development of advance directives, palliative medicine and care of the dying patient. Geriatric Urology is of great value to urologists, geriatricians, internists, residents and family practitioners.
- Section One: Hospital-based models of care:1. Acute Care for Elders -- 2. Hospital Elder Life Program -- 3. The ACE Consult program -- 4.The Advanced Dementia Consult program -- 5. Acute Care for Elders (ACE) Tracker and "e-Geriatrician" telemedicine program -- 6. The NICHE program to prepare the workforce to address the needs of older patients -- Section Two: Models to address the needs of seniors in transition from hospital to home: 7. Care Transitions Intervention.-8. The Mary Naylor Advanced Practice Nurse model -- 9. Project BOOST -- Section Three: Outpatient-based models of care: 10. The GRACE model. 11. The Guided Care model -- 12. The Stanford Chronic Disease Self-Management program -- 13. Patient Centered Medical Home -- 14. Hospital at Home model -- 15. The Physician Home Visit program.-16. Geriatrics Evaluation and Management (GEM) program -- Section Four: Emergency Department models of care: 17. Geriatrics Emergency Department -- the GEDI WISE program -- Section Five: Models which address the needs of vulnerable populations: 18. The Evercare program to care for vulnerable elders in skilled nursing facilities -- 19. The UCLA Dementia coordinator program -- 20. The Wisconsin Alzheimer's Institute memory assessment program. 21. Memory Care Connections and LEEPS program for early memory assessment -- Section Six: Community related- models of care: 22. Stepping On-falls prevention program -- 23. Program of All-Inclusive Care of Elders (PACE model) -- 24. Wisconsin Family Care social model to support seniors in their homes.
- Germ cell development in C. elegans 2013Springer
- Germline stem cells 2008Springer Protocolspt. I. Identification and regulation of germline stem cells in model organisms -- The development of germline stem cells in Drosophila / David A. Dansereau and Paul Lasko -- Analysis of the C. elegans germline stem cell region / Sarah L. Crittenden and Judith Kimble -- Immunohistological techniques for studying the Drosophila male germline stem cell / Shree Ram Singh and Steven X. Hou -- Genetic tools used for cell lineage tracing and gene manipulation in Drosophila germline stem cells / Wei Liu and Steven X. Hou -- Structural polarity and dynamics of male germline stem cells in an insect (milkweed bug Oncopeltus fasciatus) / David C. Dorn and August Dorn -- High-resolution light microscopic characterization of spermatogonia / Hélio Chiarini-Garcia and Marvin L. Meistrich -- Identification and characterization of spermatogonial subtypes and their expansion in whole mounts and tissue sections from primate testes / Jens Ehmcke and Stefan Schlatt -- Epigenetic control in male germ cells : a transillumination-assisted microdissection method for the analysis of developmentally regulated events / Durga Prasad Mishra and Paolo Sassone-Corsi -- GDNF maintains mouse spermatogonial stem cells in vivo and in vitro / Hannu Sariola and Tiina Immonen -- g pt. II. In vitro culture and application of germline stem cells -- Ectopic grafting of mammalian testis tissue into mouse hosts / Ina Dobrinski and Rahul Rathi -- Spermatogonial stem cell transplantation, testicular function, and restoration of male fertility in mice / Derek J. McLean -- Isolating highly pure rat spermatogonial stem cells in culture / F. Kent Hamra ... [et al.] -- Deriving mouse spermatogonial stem cell lines / Ilaria Falciatori ... [et al.] -- Production of knockdown rats by lentiviral transduction of embryos with short hairpin RNA transgenes / Christina Tenenhaus Dann and David L. Garbers -- Testicular germ cell tumors in mice : new ways to study a genetically complex trait / Jason D. Heaney and Joseph H. Nadeau -- Study origin of germ cells and formation of new primary follicles in adult human and rat ovaries / Antonin Bukovsky ... [et al.].
- Policies and Reimbursement: Meeting the Need for Mental Health Care in Long-Term Care / Margaret Norris -- Referrals / Michael Smith -- Assessment / Barry A. Edelstein, Lynn E. Northrop and Lisa M. MacDonald -- Treatment Plans / Deborah W. Frazer -- Treatment Process / Michael Duffy -- Integration of Psychology, Psychiatry, and Medication in Long-Term Care / Lee Hyer and Shalija Shah -- Professional Practice: Disciplines, Documentation, and Outcomes Measurement / Merla Arnold, John C. Colletti and Nicholas C. Stilwell -- Ethical Issues in Long-Term Care / Michele J. Karel.
- Print MaterialI. T. Die Ideen Hermann von Meyer's über die Schuhfrage auf Grund seiner Originalschriften.
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- Gestational diabetes during and after pregnancy 2010SpringerHyperglycemia and adverse pregnancy outcome (HAPO) study: an overview -- Evolution of screening and diagnostic criteria for GDM worldwide -- An overview of problems and solutions in the diagnosis and treatment of gestational diabetes -- Prevalence of GDM -- Risk factors for gestational diabetes: from an epidemiological standpoint -- Burden of GDM in developing countries -- Insulin and the placenta in GDM -- What causes gestational diabetes? -- Mechanisms underlying insulin resistance in human pregnancy and gestational diabetes mellitus -- Inflammation, adipokines, and gestational diabetes mellitus -- Lipids in gestational diabetes: abnormalities and significance -- Blood pressure in GDM -- Genetics of gestational diabetes mellitus and type 2 diabetes -- Maternal obesity and epidemiological review of pregnancy complications -- Maternal comorbidities during gestational diabetes mellitus: obstetrical complications, prematurity, and delivery -- The diabetic intrauterine environment: short and long-term consequences -- Exercise recommendations in women with gestational diabetes mellitus -- Nutrition and weight recommendations for treating gestational diabetes mellitus -- Pharmacological treatment options for gestational diabetes -- Risk for maternal postpartum diabetes -- Contraception before and after GDM -- Lactation and diabetes among women with a history of GDM pregnancy -- Emerging science: interventions in women at risk of GDM during pregnancy -- Diabetes prevention interventions for women with a history of GDM -- Diabetes control programs and policy.
- Gestational diabetes-- origins, complications, and treatment 2014CRCnetBASE"Discussing the origins, care, and consequences of gestational diabetes mellitus (GDM), this book focuses on evidence-based medicine to highlight various aspects of this rapidly growing condition. It provides glucose requirements for fetal growth and maternal and fetal metabolism as well as insulin secretion and sensitivity in pregnancy; covers genetic risk factors, autoimmunity, interaction with obesity, and associations with fetal growth genes; presents diet therapies and the role of exercise and nutrition; and reviews the effects of rapid-, short-, and long-acting insulin, oral hypoglycemic agents in pregnancy, and clinical approaches"--Provided by publisher.
- Get through trauma examinations 2014CRCnetBASE
- Getting started in clinical radiology from image to diagnosis 2006Thieme Book
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- G protein coupled receptors. Modeling, activation, interactions and virtual screening — Genetic analysis of complex diseases. 2nd ed. (141)
- Genetic and molecular epidemiology of multiple myeloma — Getting started with Simulink response optimization 3. Version 3. (141)
- Getting started with Stateflow 7. Version 7. — Grand challenge for the future vaccines for poverty-related diseases from bench to field (141)
- Grant application writer's handbook. 4th ed. — Gynecological imaging a reference guide to diagnosis (141)
- Harrison's Principles of Internal Medicine
- AAP Red Book Online
- Robbins & Cotran Pathologic Basis of Disease
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- Nelson's Textbook of Pediatrics
- Surgical Exposures in Orthopaedics
- Mandell, Douglas, & Bennett's Principles & Practice of Infectious Diseases
- Red Book Online
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