- Fabry disease — Fire defense section bulletin (145)
- First aid cases for the USMLE step 2 CK. 2nd ed. — Foodborne diseases (145)
- Foodborne microbial pathogens : mechanisms and pathogenesis — Frozen section library. Head and neck (145)
- Frozen section library. Liver, extrahepatic biliary tree, and gallbladder — Fuzzy and rough techniques in medical diagnosis and medication (143)
- 2008 SpringerArun K. Bhunia.
- 2015 SpringerKaj Klaue.ANAMNESIS: Timetable of disorder (progression, trauma, previous surgery, chronology) -- Type of disorder -- Localization -- Activity dependence -- Barometric dependence -- Personal anamnesis (other pathologies and surgery). CLINICAL EXAMINATION: Independent walk, gait -- Static (standing on the cube and podoscope) -- Passive joint mobility (sitting on the cube) -- Active joint mobility -- Joint stability -- Visualization and palpation. RADIOLOGICAL SCREENING: Conventional radiographs -- CT -- MRI. SURGICAL CORRECTIONS: Reorientation of the upper ankle joint -- Reorientation of the lateral malleolus -- Osteochondroplasty of the talus -- Lateralisation of the hindfoot axis -- Reorientation arthrodesis of the subtalar joint -- Ligamentous reconstruction of the ligaments about the upper ankle joint -- Removal of impingements at the upper ankle joint -- Removal of impingements at the lower ankle joint -- Reorientation of the lower ankle joint -- Functional extension of the hindfoot -- Tibialis anterior tendon transfer on the lateral dorsum of the foot -- Flexor digitorum longus tendon transfer onto the first cuneiform -- Fibularis longus tendon transfer onto the fifth metatarsus -- Flexor hallucis longus tendon transfer on the fifth metatarsus -- Reorientation of the first tarso-metatarsal joint -- Reorientation of the lesser metatarsal heads -- Functional correction of the toes.
- 2016 SpringerHong-Geun Jung, editor.1. Ankle sprain and instability -- 2. OLT, Soft tissue impingement and Sinus Tarsi Syndrome -- 3. Achilles tendon: Tendinosis and Rupture -- 4. Plantar fasciitis -- 5. Ankle OA (I) -- A/S debridement, LTO, Distraction Arthroplasty -- 6. Ankle OA (II) -- Arthrodesis, TAA -- 7. Flatfoot deformity -CHILD, Adult -- 8. Cavovarus foot deformity -- 9. Hallux valgus -- 10. Morton's Neuroma -- 11. Charcot neuropathic joint -- 12. Diabetic foot -- ulcer, infection.
- 2006 Springer[edited by] Maurice Bouysset, Yves Tourné, and Karl Tillmann.Diagnosis of rheumatoid arthritis at an early stage / P. Miossec and J. Tebib, p. 1-8 -- The Rheumatoid foot. Pathomechanics, clinical and radiological features. Therapeutic conditions / M. Bouysset and P. Hugueny, p. 9-48 -- Some reflections on pathomechanics of the rheumatoid foot and ankle / X. Crevoisier, p. 49-72 -- CT and MRI in rheumatoid arthritis (midfoot, hindfoot and ankle) / Th. Tavernier, p. 73-95 -- Management of the patient with rheumatoid arthritis / J. Tebib and P. Miossec, p. 97-109 -- Footwear for the rheumatoid foot and ankle / M. Bouysset, P. Hugueny, G. Guaydier-Souquières and F. Lapeyre, p. 111-121 -- Corticosteroid injections and synoviortheses of the foot and ankle in rheumatoid arthritis / M. Bouysset, P. Hugueny, B. Gintz, J. Jalby and J. Tebib, p. 123-130 -- Forefoot surgery for rheumatoid arthritis / Y. Tourné, p. 131-147 -- Hindfoot surgery for rheumatoid arthritis / B. Valtin and Th. Leemrijse, p. 149-167 -- Points of view about synovectomy of the ankle joint in rheumatoid arthritis / H. Thabe, p. 169-178 -- Total ankle replacement. History, evolution of concepts, designs and surgical technique / M. Bonnin, T. Judet, T. Siguier and J. Colombier, p. 179-200 -- Some reflections about the evolution of ankle prosthesis / H. Kofoed, p. 201-206 -- Total ankle replacement in rheumatoid arthritis: treatment strategy / M. Bonnin, M. Bouysset, J. Tebib and E. Noël, p. 207-219 -- Respective indications of talocrural arthrodesis and ankle prosthesis with different situations in rheumatoid arthritis / K. Tillmann and B. Fink, p. 221-228 -- Surgical strategy in surgery of the lower limb in rheumatoid arthritis / W. Souter, p. 229-236 -- Surgery of the foot and ankle in patients with rheumatoid arthritis: some reflexions / F. Koeck, G. Heers, W. Caro and J. Grifka, p. 237-46.
- 2008 CRCnetBASEedited by Gerald F. Harris, Peter A. Smith, Richard M. Marks.
- 2015 OvidRobert A. Christman.
- 2010 ClinicalKey[edited by] Glenn B. Pfeffer, Mark E. Easley, Carol Frey, Beat Hintermann and Andrew K. Sands.Hallux Valgus Correction with Modified Chevron Osteotomy -- Scarf Osteotomy for Correction of Hallux Valgus -- Modified "Lapidus" Procedure-Tarsometatarsal Corrective Osteotomy and Fusion with First Metatarsophalangeal Joint Correction and Realignment -- Proximal Long Oblique (Ludloff) First Metatarsal Osteotomy with Distal Soft Tissue Procedure -- Hallux Rigidus: Cheilectomy with and without a Dorsiflexion Phalangeal Osteotomy -- Arthrodesis of the Great Toe Metatarsophalangeal Joint -- Forefoot Reconstruction for Rheumatoid Disease -- Fifth Metatarsal Osteotomy for Correction of Bunionette Deformity -- Turf Toe Repair: Capsular Repair of First Metatarsophalangeal Plantar Plate Rupture -- Morton's Neuroma -- Revision Surgery through a Plantar Approach for Recurrent Interdigital Neuroma -- Deviated Lesser Toe/Metatarsal Shortening (Weil) Osteotomy -- Correction of Acquired Hallux Varus -- Arthroscopy of the Great Toe -- Metatarsal Lengthening -- Internal Fixation of the Sesamoid Bone of the Hallux -- Cavovarus Correction in Charcot-Marie-Tooth Disease -- Charcot Neuroarthropathy of the Midfoot/Hindfoot -- Midfoot Arthrodesis in Charcot Foot Deformity with "Charcot Screws" -- Open Reduction and Internal Fixation of Lisfranc/Tarsometatarsal Injuries -- Painful Accessory Navicular: Augmented Kidner Procedure with Flexor Digitorum Longus Transfer -- Painful Accessory Navicular Treated with Fusion -- Open Reduction and Internal Fixation of Proximal Fifth Metatarsal (Jones' or Stress) Fracture -- Open Reduction and Internal Fixation of the Cuboid Fracture/Nutcracker Injury -- Total Ankle Arthroplasty with a Current Three-Component Design (HINTEGRA Prosthesis) -- Salvage of Failed Total Ankle Arthroplasty -- Ankle Arthrodesis for Salvage of the Failed Total Ankle Arthroplasty -- Ankle Arthrodesis Using Ring/Multiplanar External Fixation -- Arthroscopic Ankle Arthrodesis -- Rigid Fixation for Ankle Arthrodesis Using Double Plating -- Tibiotalocalcaneal Fusion with a Retrograde Intramedullary Nail -- Realignment Surgery for Valgus Ankle Osteoarthritis -- Osteochondral Lesion of the Ankle-OATS Procedure -- Mosaicplasty with Bone-Periosteum Graft from the Iliac Crest for Osteochondral Lesions of the Talus -- Arthroscopy of the Subtalar Joint -- Modified Brostrom Procedure for Lateral Ankle Laxity -- Lateral Ankle Ligament Reconstruction Using Plantaris Autograft -- Salvage of a Failed Lateral Ligament Repair -- Lateral Ankle Reconstruction with the Fourth Extensor Digitorum Communis Tendon -- Ligament Reconstruction for Chronic Medial Ankle Instability -- Ligament Reconstruction for Chronic Medial Ankle Instability -- Exosectomy for Haglund's Disease -- Haglund's Deformity: Open and Arthroscopic Treatment -- Intra-articular Calcaneus Fractures -- Calcaneus Open Reduction and Internal Fixation with Extensile Lateral Incision -- Osteotomies for the Correction of Varus Ankle -- Tarsal Tunnel Syndrome -- Anterior Ankle Impingement -- Lateral Calcaneal Lengthening Osteotomy for Supple Adult Flatfoot -- Single Medial Approach for Triple Arthrodesis -- Triple Arthrodesis -- Treatment of Distal Achilles (Insertional) Degeneration and Associated Calf Tightness Plus Calcaneal Tuber Exostosis -- Achilles Tendon Reconstruction with Flexor Hallucis Longus Transfer Augmentation -- Peroneal Tendon Tears: Débridement and Repair -- Chronic Peroneal Tendon Subluxation-Dislocation -- Posterior Tibial Tendon Transfer for Footdrop -- Calf Lengthening for Equinus Contracture -- Proximal Tibia Bone Graft -- Anterior Leg Compartment Release for Exertional Compartment Syndrome.
- 2003 Wellcome Trustedited by L.A. Reynolds and E.M. Tansey.
- 2005 SpringerB.W.J. Mahy (ed.)Also available: Print – 2005
- 2015 SpringerPiero Volpi, editor.
- Footmarks of innate immunity in the ovary and cytokeratin-positive cells as potential dendritic cells2011 SpringerKatharina Spanel-Borowski.The cyclic ovary can be seen as a site of tissue damage, repair and precisely controlled tissue homeostasis, as long ovulation and luteolysis can be compared with acute and chronic inflammation. Innate immunity appears to be a powerful force in the endocrine system, representing a novel concept. In this monograph, remarkable evidence is given for the immune-privileged ovary being an implant on the chicken chorioallantoic membrane with an areactive mesenchyme. Mild to severe tissue damages due to follicular atresia, follicular rupture, or intraovarian oocyte release do no lasting harm. The most exciting part relates to the analysis of cytokeratin-positive (CK<sup>+</sup>) cells, comparing the fate mapping of this cell type from the fetal ovary to the adult organ. Findings on toll-like receptor 4 regulation and interferon-gamma-dependent positive effects indicate that CK<sup>+</sup> cells from human preovulatory follicles and bovine corpora lutea have similarities with nonlymphoid dendritic cells, a discovery that has the makings of a top story in basic and clinical research on the ovary.
- 2013 Springerby Frank Scalia, John J. Rasweiler IV, Jason Scalia, Rena Orman, Mark Stewart.Carollia perspicillata, a tropical species, is the only bat that has essentially been domesticated and can be maintained and propagated in a research environment utilizing simple, inexpensive husbandry procedures. This atlas contains the first quality treatment of a bat species, and is unique in its use of NeuN staining. The NeuN preparations used selectively stain neurons in a sharp black coloration that fills not only the cell body but extends a short distance along the proximal dendrites. Thus, as distinct from the traditional nissl stains, the NeuN generates a quasi Golgi-like image of the neurons, providing a more intimate view of the neurons than can be obtained from nissl staining. In addition, the background is essentially white, facilitating high-contrast photography and allowing for gray-tone illustration without any loss of information. The NeuN procedure does not stain axons, and since it does not stain glial cells or their nuclei, the noise ordinarily generated in nissl stains by the presence of glial cells among the neurons and in the white matter is entirely eliminated. The Forebrain Atlas of the Short-tailed Fruit Bat also includes nissl stained sections for comparison. Since it is known that NeuN is not expressed in certain neurons, such as Purkinje cells, olfactory bulb mitral cells, and the cells of the paraventricular and supraoptic nuclei, the nissl stained sections are also included to provide complementary views of such structures.
- 2006 Springeredited by Aurore Schmitt, Eugénia Cunha, and João Pinheiro.
- 2008 CRCnetBASEeditors, Michael W. Warren, Heather A. Walsh-Haney, and Laurel E. Freas.Introduction / Heather Walsh-Haney -- The Anthropology Research Facility, University of Tennessee / Lee Meadows Jantz and Richard L. Jantz -- The forensic anthropology laboratory in a medical examiner setting / Dana Austin and Laura Fulginiti -- Joint POW/MIA Accounting Command's Central Identification Laboratory / Thomas Holland, John Byrd and Vincent Sava -- The University of Indianapolis Archeology & Forensics Laboratory / Stephen P. Nawrocki -- The mass fatality incident morgue : a laboratory for disaster victim identification / Paul S. Sledzik and Patricia J. Kaufmann -- The Repatriation Osteology Laboratory at the Smithsonian Institution / Erica B. Jones and Stephen D. Ousley -- History and collections of the Division of Physical Anthropology, Smithsonian Institution / David R. Hunt -- The LSU Forensic Anthropology and Computer Enhancement Services Laboratory / Mary H. Manhein ... [et al.] -- The working forensic anthropology laboratory / Heather Walsh-Haney, Laurel Freas and Michael Warre.
- 2015 Wileyedited by W.J. Mike Groen, Nicholas Márquez-Grant and Robert C. Janaway.
- 2012 WileyJules Kieser, Michael Taylor, Debra D. Carr.Basic principles of biomechanics -- Biomechanics of bone and bony trauma -- Biomechanics of skin and soft tissue trauma -- The mechanics of bloodstain pattern formation -- Fibres and textiles.
- 2009 CRCnetBASEBasil RuDusky.
- 2014 CRCnetBASEedited by Dragan Primorac, M.D., Ph.D., Adjunct Professor of Forensic Science, Eberly College of Science, Pennsylvania State University, University Park, PA, USA, and Henry C. Lee College of Criminal Justice and Forensic Sciences, University of New Haven, West Haven, CT, USA, Professor of Pediatric Medicine, School of Medicine, University of Split, Split, Croatia and School of Medicine, University of Osijek, Osijek, Croatia; Moses Schanfield, Ph.D., Professor of Science and Anthropology, Department of Forensic Science, George Washington University, Mount Vernon Campus, Washington, D.C., USA.
- 2007 Springerby Katherine Mainolfi Koppenhaver.Evolution of the written word -- Principles of handwriting -- Factors that cause changes in handwriting -- Handprinting and numerals -- History of document examination -- Forgery -- Other types of fraud -- Equipping a laboratory -- Care and handling of documents -- Standards of comparison -- Systematic examination of handwriting -- Master pattern -- Detecting fraudulent documents -- Weighing the evidence -- Preparing reports -- Alteration of documents -- Disguised writing -- Disguise versus simulation -- Check and credit card fraud -- Paper -- Writing instruments -- Seals, stamps, and paper -- Typewriters and printers -- Duplicating methods -- Desktop publishing -- The discovery process -- The litigation process -- Demonstrative evidence -- Court cases.
- 2007 Ovideditors, Jonathan S. Olshaker, M. Christine Jackson, William S. Smock ; editorial coordinator, Linda J. Kesselring.Perpetrators / John E. Douglas and Mark Olshaker -- The Victims of violence / Carroll Ann Ellis -- Interviewing techniques / Peggy L. Johnson and John S. O'Brien II -- Forensic emergency medicine: penetrating trauma / William S. Smock -- Forensic aspects of motor vehicle trauma / William S. Smock -- Forensic examination of adult victims and perpetrators of sexual assault / Judith A. Linden, Annie Lewis-O'Connor, and M. Christine Jackson -- Sexual abuse and sexual assault of adolescents / V. Jill Kempthorne -- Child sexual assault: the acute assessment / Mary-Theresa L. Baker -- Child abuse/assault / Richard Lichenstein and Adrienne H. Suggs -- Elder abuse / Adam J. Geroff and Jonathan S. Olshaker -- Treating survivors of intimate partner abuse: forensic identification and documentation / Daniel J. Sheridan -- New drugs of abuse / K. Sophia Dyer -- Serology and DNA evidence / Rosalind Bowman, Teri J. Labbe, and Kimberly A. Mullings -- Law enforcement / Donald E. Steinhice -- Sexual assault and the criminal justice system / Sharon A.H. May -- Testifying / Sharon A.H. May -- Forensic photography in the emergency department / William S. Smock and Patrick E. Besant-Matthews.
- 2010 CRCnetBASESteven A. Koehler, Peggy A. Brown.
- 2014 Cambridgeedited by Maureen Dalton, Clinicial Lead Advisor to the South West Sexual Assault Referral Centre, Commissioning, UK.1. Initial contact -- 2. Significant law: sexual offence medicine -- 3. The history -- 4. Consent -- 5. The sexual assault examination kit -- 6. The general examination -- 7. The examination: injuries -- 8. The genital examination -- 9. Aftercare: genitourinary medicine issues -- 10. Aftercare: emergency contraception -- 11. Aftercare: psychological issues -- 12. The statement -- 15. Sexual abuse of the elderly -- 16. Child sexual abuse -- 17. Child sexual exploitation -- 18. Female genital mutilation -- 19. Domestic abuse -- 20. Education and training.
- 2011 SpringerReinhard B. Dettmeyer.Introduction -- Staining Techniques and Microscopy -- Histopathology of Selected Trauma -- Histopathology and Drug Abuse -- Toxin- and Drug-Induced Pathologies -- Alcohol-Related Histopathology -- Heat, Fire, Electricity, Lightning, Radiation, and Gases -- Hypothermia -- Thrombosis and Embolism -- Vitality, Injury Age, Determination of Skin Wound Age, and Fracture Age -- Aspiration and Inhalation -- Forensic-Histological Diagnosis of Species, Gender, Age, and Identity -- Coronary Sclerosis, Myocardial Infarction, Myocarditis, Cardiomyopathy, Coronary Anomalies, and the Cardiac Conduction System -- Vascular, Cardiac Valve, and Metabolic Diseases -- Lethal Infections, Sepsis, and Shock -- Endocrine Organs -- Pregnancy-Related Death, Death in Newborns, and Sudden Infant Death Syndrome -- Forensic Cytology -- Histothanatology: Autolysis, Putrefaction, Mummification -- Forensic Neuropathology.
- 2007 CRCnetBASEedited by Timothy Thompson, Susan Black.section 1. Identification from biomolecular evidence -- section 2. Identification from latent prints -- section 3. Identification from the soft tissues -- section 4. Identification from the hard tissues -- section 5. Facial identification -- section 6. Identification from methods of communication -- section 7. Identification from podiatry and walking -- section 8. Identification from personal effects -- section 9. The Context of forensic human identification -- section 10. Forensic human identification case studies.
- 2006 ScienceDirect[edited by] Eric Stauffer, Monica S. Bonfanti.The problem of auto theft / Mikel Longman -- Victim and witness interviews and collection of circumstantial information / Jean-François Chevalley, Manuel Poza -- General crime scene considerations and documentation / Moira Johnson, Simone Reynolds -- Forensic examination of stolen-recovered vehicles : technical examination and general forensic traces / Marc Demierre ; Chemical traces--drugs, explosives, and gunshot residue / Francesco Saverio Romolo -- Traces and their evidentiary value / Eric Stauffer -- Vehicle identification / William T. Smylie -- Restoration of serial numbers / Horst Katterwe -- Anti-theft systems / Robert F. Mangine -- Examination of steering columns and ignition locks / Robert F. Mangine -- Examination of vehicle keys / Emmanuel Fivaz, Monica S. Bonfanti -- Analysis of vehicle fluids / Eric Stauffer -- Examination of burned vehicles / Eric Stauffer -- Examination of vehicles recovered underwater / Jean-François Voillot -- Examination of vehicle license plates / Didier Brossier -- Examination of vehicle registration documents / Diana Ombelli -- Vehicle searching procedures / Stéphane Kummer -- Examination of vehicles involved in terrorism / Greg Terp -- Investigation from the public side / Greg Terp -- Investigation from the private side : the European perspective / Marc Stauffer ; The U.S. perspective / Glenn Wheeler -- Vehicle tracking / Greg Terp -- Vehicle crime mapping / Jerry Ratcliffe -- International collaboration through Interpol / Alain G. Barbier.
- 2008 CRCnetBASEedited by Steven B. Karch.Measuring acute alcohol impairment / Christopher S. Martin -- Update on clinical and forensic analysis of alcohol / Alan Wayne Jones and Derrick J. Pounder -- Post-mortem alcohol: aspects of interpretation / Derrick J. Pounder and Alan Wayne Jones -- Recent advances in biochemical tests for acute and chronic alcohol consumption / Anders Helander and Alan Wayne Jones -- Alcohol determination in point of collection testing / J. Robert Zettl.
- 2006 Springeredited by Ashraf Mozayani, Carla Noziglia.Serology and DNA / Lisa A. Gefrides and Katherine E. Welch -- Forensic chemistry / Donnell Christian -- Crime reconstruction / W. Jerry Chisum -- Digital evidence / Robert P. Bianchi and Mark Pollitt -- Explosives and arson : boom and flame / James B. Crippin -- Fingerprints / Brian E. Dalrymple -- Firearms and tool marks / Edward E. Hueske -- Forensic odontology : teeth and their secrets / Helena Soomer / Forensic pathology / Joye Carter -- Assuring quality in the crime laboratory / William J. Tilstone -- Introduction to forensic document Examination / William L. Leaver -- Toxicology in the crime laboratory / Ashraf Mozayani -- Trace evidence in the real crime lab / Richard E. Bisbing.
- 2007 CRCnetBASEMichael P. Burke.
- 2014 Springerby Reinhard B. Dettmeyer, Marcel Verhoff, Harald Schutz.Introduction -- The External Postmortem Examination -- Thanatology -- Autopsy (Syn. Postmortem Examination, Necroscopy) -- Exhumation -- Establishing Identity -- Vital Reactions -- Blunt Force Trauma -- Pointed, Sharp, and Semi-sharp Force Trauma -- Gunshot and Blast Wounds -- Neck Trauma -- Thermal Injury -- Electricity, Lightning, and Gases -- Asphyxia -- Water-Related Deaths -- Death by Starvation and Dehydration -- Clinical Forensic Medicine -- Child Abuse -- Child Sexual Abuse -- Infanticide and Neonaticide -- Traffic Medicine -- Forensic DNA Analysis -- Forensic Osteology -- Forensic Radiology -- Special Case Constellations in Natural, Unexplained, and Unnatural Deaths -- Torture -- Forensic Psychopathology -- Medical Malpractice -- Forensic Alcohology -- Forensic Toxicology.
- 2012 Springer Protocolsedited by Lynne S. Bell.Scanning electron microscopy : preparation and imaging for SEM / Chris G. Jones -- Plastic embedding and polishing of bone for reflected light and electron microscopy / A.H.J. Wighton, Chris G. Jones, and Lynne S. Bell -- Preparation of mineralized tissue for light microscopy / Gail Valentine and Kim Piper -- Bone pathology / Kim Piper and Gail Valentine -- Histological method that can be used to estimate the time taken to form the crown of a permanent tooth / M. Christopher Dean -- Determination of age in subadult from the rib cortical microstructure / Margaret Streeter -- Rib histomorphometry for adult age estimation / Christian Crowder, Jarred Heinrich, and Sam D. Stout -- Age estimation using tooth cementum annulation / Ursula Wittwer-Backofen -- Dental topographic analysis of the molar teeth of primates / Zachary S. Klukkert [and others] -- Chemical analyses of fossil bone / Wenxia Zheng and Mary Higby Schweitzer -- Identifying postmortem microstructural change to skeletal and dental tissues using backscattered electron imaging / Lynne S. Bell -- How to approach perimortem injury and other modifications / Peter Andrews and Yolanda Fernandez-Jalvo -- Light microscopy of microfractures in burned bone / Christopher W. Schmidt and Rose Uhlig -- Preliminary assessment of using a white light confocal imaging profiler for cut mark analysis / Christopher W. Schmidt, Christopher R. Moore, and Randell Leifheit -- Identification of cooked bone using TEM imaging of bone collagen / Hannah E.C. Koon.
- 2006 SpringerM. Oehmichen, R.N. Auer, H.G. König ; with a foreword by Kurt A. Jellinger.Introduction -- Risks, responsibilities and liabilities -- Cytology of the CNS -- Cell and tissue reactions -- Methods in forensic neuropathology -- Basic principles of mechanical trauma -- Injuries of the brain's coverings -- Open brain injuries -- Closed brain injuries -- Injuries of spine and spinal cord -- Injuries of peripheral nerves -- Special physical trauma -- Hypoxia, ischemia (hypoglycemia) -- Forensic types of ischemia and asphyxia -- Permanent global ischemia -- Introductory remarks -- Specific types of neurotoxins -- Alcohol, organic solvents, and aerosols -- Illegal drugs and drug dependence -- Basic principles -- Fetal neuropathology -- Perinatal CNS injury -- Postnatal natural CNS death -- Postnatal mechanical brain injury (MBI) -- Physical abuse -- Basic principles -- Seizures and epilepsy -- Vascular diseases -- Inflammatory diseases -- Nutritional and metabolic insults -- Aging and brain pathology.
- 2013 Wiley[edited by] Catherine Adams, Romina Carabott, and Sam Evans.Introduction-editors -- Dental anatomy & development / Alastair Sloan -- Expert witness skills / Jason Tucker -- Mortuary practice / Ali Anderson -- Dental human identification / Romina Carabott -- Disaster victim identification / Cath Adams -- Dental age assessment / Sakher J. Al Qahtani -- Bite marks 1 / Douglas Sheasby -- Bite marks 2 / Roland Kouble -- Forensic photography / Sam Evans -- The role of the fo in protection of the vulnerable person / Catherine Adams & Barbara Chadwick.
- 2007 Springerby Michael J. Shkrum and David A. Ramsay.The "complete autopsy" : the management of risk -- Postmortem changes : the "great pretenders" -- Asphyxia -- Thermal injury -- Bodies recovered from water -- Penetrating trauma: close-range firearm wounds -- Penetrating trauma: sharp force injuries -- Blunt trauma : with reference to planes, trains, and automobiles -- Craniocerebral trauma and vertebrospinal trauma -- Sudden neurological death.
- 2006 Springeredited by Tom Mason.Organizations as evil structures / Dave Holmes and Cary Federman -- The psychopharmaceutical complex / Brian Kean -- Intention, excuse, and insanity / Tamas Pataki -- An archaeology of the "psychopath": the medicalization of evil / Tom Mason -- The comforts of evil: dangerous personalities in high-security hospitals and the horror film / Mick McKeown and Mark Stowell-Smith -- Madness, badness, and evil / Deidre N. Greig -- Destruction as a constructive choice / David A. Winter -- Violence as secular evil: forensic evaluation and treatment of violent offenders from the viewpoint of existential depth psychology / Stephen A. Diamond -- Scapegoat, spectacle, and confessional: close encounters with sex offenders and other species of dangerous individuals / Dave Mercer and Joel Richman -- The villification of victimized children in historical perspective / Victoria Van Slyke -- Evil: a clinical perspective / J. David Kinzie -- Capacities and dispositions: what psychiatry and psychology have to say about evil / Gwen Adshead -- Should radical evil be forgiven? / Marguerita La Caze -- Mad, bad, and evil: psychiatry, psychoanalysis, and evil / Michael Levine -- Talking about evil, even when it's not supposed to exist / C. Fred Alford -- The influence of evil on forensic clinical practice / Tom Mason, Joel Richman, and Dave Mercer -- Hope in the face of evil / Geri Miller and Ron Hood.
- 2004 CRCnetBASEJohn C. Brenner.
- 2011 CRCnetBASEConnie Darnell."This book contains basic forensic information necessary for healthcare professionals to assess and manage victims of trauma and criminal behavior. Chapters cover information on types of wounds and how to describe them; various types of evidence which may be encountered in the healthcare setting; and general principles of evidence collection. Common evidentiary items such as clothing, foreign objects, trace evidence, biological evidence, and bite marks are discussed and collection procedures are identified."--Provided by publisher.
- 2008 ClinicalKeyedited by Neil McIntosh, Peter J. Helms, Rosalind L. Smyth, Stuart Logan.Also available: Print – 2008
- 2003Fred Luskin.Pt. 1. Creating a grievance -- pt. 2. Forgiveness -- pt. 3. Forgive for good.
- Forgive for love : the missing ingredient for a healthy and lasting relationship. 1st HarperCollins pbk. ed.2009Fred Luskin.Offers a seven-step program for creating and maintaining a lasting relationship that teaches forgiveness skills in order to resolve conflicts and increase happiness.
- 2012 SpringerAnna Kuchment.1. Helpful Little Bodies -- 2. Inside Stalin's Empire -- 3. The Fading of Phage Therapy -- 4. Naked Genes -- 5. 'They're Not a Panacea:' Phage Therapy in the Soviet Union and Georgia -- 6. In Poland: Phages for Diabetes? -- 7. The Renaissance of Phage Therapy -- 8. The Startups -- 9. Four Companies, Four Strategies -- 10. Cows and Chickens -- 11. Approval, At Last -- 12. In Treatment.
- Forgotten people, forgotten diseases : the neglected tropical diseases and their impact on global health and development. 2nd ed.2013 ASMPeter J. Hotez.Provides an overview of the neglected tropical diseases (NTDs) and how they devastate the poor, essentially trapping them in a vicious cycle of extreme poverty by preventing them from working or attaining their full intellectual and cognitive development.
- 2009 Springeredited by Kenneth Maiese.FOXO1, T-cell trafficking and immune responses / Florent Carrette, Stéphanie Fabre and Georges Bismuth -- FOXP3 and its role in the immune system / Chang H. Kim -- Molecular regulation of cellular immunity by FOXP3 / Alicia N. McMurchy ... [et al.] -- The biology of FOXP3 : a key player in immune suppression during infections, autoimmune diseases and cancer / Frances Mercer and Derya Unutmaz -- The cooperative roles of FOXC1 and FOXC2 in cardiovascular development / Tsutomu Kume -- FOXO proteins and cardiac pathology / Albert Wong and Elizabeth A. Woodcock -- The forkhead transcription factors play important roles in vascular pathology and immunology / Xiao-Feng Yang ... [et al.] -- Regulatory T cells, FOXP3 and atherosclerosis / Michal Entin-Meer, Arnon Afek and Jacob George -- FOXP genes, neural development, speech and language disorders / Hiroshi Takahashi, Kaoru Takahashi and Fu-Chin Liu -- Pathophysiological relevance of forkhead transcription factors in brain ischemia / Kohji Fukunaga and Norifumi Shioda -- New insights for FOXO and cell-fate decision in HIV infection and HIV associated neurocognitive disorder / Min Cui ... [et al.] -- FOXP3+ regulatory T-cells in chronic kidney disease : molecular pathways and clinical implications / Pascal Meier -- Transcriptional role of FOXO1 in drug resistance through antioxidant defense systems / Tomoko Goto and Masashi Takano -- FOXP3 expressing regulatory T-cells in allergic disease / Kayhan T. Nouri-Aria -- Human clinical phenotype associated with FOXN1 mutations / Claudio Pignata, Anna Fusco and Stefania Amorosi -- FOXL2 : at the crossroads of female sex determination and ovarian function / Bérénice A. Benayoun ... [et al.] -- FOXO transcription factors : from cell fate decisions to regulation of human female reproduction / Jan J. Brosens, Miranda S.C. Wilson and Eric W.-F. Lam -- The "O" class : crafting clinical care with FOXO transcription factors / Kenneth Maiese ... [et al.].Also available: Print – 2009
- 2006 IARC
- 2011 Springer Protocolsedited by Fahd Al-Mulla.Regulatory and ethical Issues on the utilization of FFPE tissues in research / Catherine M. With, David L. Evers, and Jeffrey T. Mason -- Tissue microarrays : construction and uses / Carol B. Fowler ... [et al.] -- Standardization in immunohistology / Anthony S.-Y. Leong and Trishe Y.-M. Leong -- Multiple immunofluorescence labeling of formalin-fixed paraffin-embedded tissue / David Robertson and Clare M. Isacke -- Microwaves for chromogenic In situ hybridization / Anthony S.-Y. Leong and Zenobia Haffajee -- Automated analysis of FISH-stained HER2/neu samples with metafer / Christian Schunck and Eiman Mohammad -- Laser capture microdissection of FFPE tissue sections bridging the gap between microscopy and molecular analysis / Renate Burgemeister -- Nucleic acids extraction from laser microdissected FFPE tissue sections / Renate Burgemeister -- Microarray-based CGH and copy number analysis of FFPE samples / Fahd Al-Mulla -- Microarray profiling of DNA extracted from FFPE tissues using SNP 6.0 affymetrix platform / Marianne Tuefferd ... [et al.] -- Whole genome amplification of DNA extracted from FFPE tissues / Mira Bosso and Fahd Al-Mulla -- Pyrosequencing of DNA extracted from formalin-fixed paraffin-embedded tissue / Brendan Doyle, Ciaran O'Riain, and Kim Appleton -- Analysis of DNA methylation in FFPE tissues using the methylight technology / Ashraf Dallol ... [et al.] -- RT-PCR gene expression profiling of RNA from paraffin-embedded tissues prepared using a range of different fixatives and conditions / Mei-Lan Liu ... [et al.] -- RT-PCR-based gene expression profiling for cancer biomarker discovery from fixed, paraffin-embedded tissues / Aaron Scott ... [et al.] -- MicroRNA isolation from formalin-fixed, paraffin-embedded tissues / Aihua Liu and Xiaowei Xu -- Gene expression profiling of RNA extracted from FFPE tissues : NuGEN technologies' whole-transcriptome amplification system / Leah Turner, Joe Don Heath, and Nurith Kurn -- Protein mass spectrometry applications on FFPE tissue sections / Carol B. Fowler, Timothy J. O'Leary, and Jeffrey T. Mason -- Alternative fixative to formalin fixation for molecular applications : the RCL2®-CS100 approach / Amelie Denouel ... [et al.].
- Also available: Print – 1943
- 2016 SpringerRobert O. Williams III, Alan B. Watts, Dave A. Miller, editors.
- 2012 SpringerRobert O. Williams, Alan B. Watts, Dave A. Miller, editors.1. Route-Specific Challenges in the Delivery of Poorly Water-Soluble Drugs / Stephanie Bosselmann and Robert O. Williams III -- 2. Optimizing the Formulation of Poorly Water-Soluble Drugs / Kevin P. O'Donnell and Robert O. Williams III -- 3. Solid-State Techniques for Improving Solubility / Justin R. Hughey and Robert O. Williams III -- 4. Mechanical Particle-Size Reduction Techniques / Javier O. Morales, Alan B. Watts, and Jason T. McConville -- 5. Solubilized Formulations / Feng Zhang and James C. DiNunzio -- 6. Injectable Formulations of Poorly Water-Soluble Drugs / Michael P. Boquet and Dawn R. Wagner -- 7. Design and Development of Self-Emulsifying Lipid Formulations for Improving Oral Bioavailability of Poorly Water-Soluble and Lipophilic Drugs / Ping Gao -- 8. Structured Development Approach for Amorphous Systems / Navnit Shah, Harpreet Sandhu, Duk Soon Choi, Oskar Kalb, Susanne Page, and Nicole Wyttenbach -- 9. Melt Extrusion / James C. DiNunzio, Feng Zhang, Charlie Martin, and James W. McGinity -- 10. Spray-Drying Technology / Dave A. Miller and Marco Gil -- 11. Pharmaceutical Cryogenic Technologies / Wei Yang, Donald E. Owens III, and Robert O. Williams III -- 12. Precipitation Technologies for Nanoparticle Production / Jasmine M. Rowe and Keith P. Johnston -- 13. Emerging Technologies to Increase the Bioavailability of Poorly Water-Soluble Drugs / Justin R. Hughey and James W. McGinity -- 14. Scientific and Regulatory Considerations for Development and Commercialization of Poorly Water-Soluble Drugs / Zedong Dong and Hasmukh Patel.
- v. 1-4, 1960-64. Karger
- 2000 Internet ArchiveStanford University School of Medicine ; editor, Kate Ruddon.Profiles of forty alumni of Stanford University School of Medicine who have devoted their careers to advancing medical science, education, and patient care.
- Fostering nurse-led care : professional practice for the bedside leader from Massachusetts General Hospital2013 ProQuest Ebook Central[edited by] Jeanette Ives Erickson, Dorothy A. Jones, Marianne Ditomassi."Nurse leaders exist at every level--from the bedside to the boardroom. But these days, nurse leaders and managers face major changes in health care delivery models that pressure them to improve patient care but at the same time improve efficiency and lower costs. Add to this the demand to provide nursing education and improve retentions, and the pressure can mount and create additional problems for your organization. The solution? Fostering Nurse-Led Care--from three of Massachusettes General Hospital's top nurse executives--tells nurse leaders and care providers the secrets of the professional practice model that has improved system outcomes and increased patient, family, and staff satisfaction for nearly 20 years. The book provides details including developing, implementing, and evaluating a professional practice environment; optimizing quality standards; implementing patient safety measurements and balancing cost with quality; building an effective learning environment; and resolving conflicts and ethical dilemmas"--Page 4 of cover.
- 2009Herausgeberin, Corey Keller ; Essays von Maren Gröning, Tom Gunning, Jennifer Tucker ; [Übersetzung, Wolfgang Astelbauer].
- 2012 SpringerKwang-Kuo Hwang."Originally, the global exporting of psychology was considered a means of bringing science and modernism to underdeveloped parts of the world. In response, indigenous psychology has emerged as an alternative to the individual-focused theories and therapies of Western cultures, as well as a critique of the idea that the tenets of Western thought apply to all nations. The first full-length work analyzing its Confucian roots, Foundations of Chinese Psychology strips away the myths and assumptions that can impede reliable scholarship while supplying the context necessary for decoding complex, longstanding traditions of behavior. The author re-interprets the widely held idea of collectivism (which is often defined as the absence of individualism) in favor of the more descriptive relationism, using the structure of Confucian ethics as a lens for testing theories and understanding findings on Chinese social relationships. Elaborating on key concepts such as guanxi (personal connection) and face (social standing), the book offers both a specific paradigm for studying non-Western cultures and a model for indigenous psychologies worldwide. Included in the coverage: The Confucian model of mind and the way of humanity; Confucian relationalism and social exchange; Life goals and achievement motivation in Confucian society; Ethics, morality, and the concept of face; Guanxi and organizational behavior. Indigenous Chinese models of conflict resolution. Foundations of Chinese Psychology is a landmark volume of immediate interest to researchers, particularly members of the American Psychological Association, the Asian Association of Indigenous and Cultural Psychology, the International Academy of Intercultural Research, and similar organizations."--Publisher's website.
- 2009Leslie G. Portney, Mary P. Watkins.
- 2007Arcady R. Mushegian.The beginning of computational genomics -- Finding sequence similarities -- Homology: can we get it right? -- Getting ready for the era of comparative genomics: the importance of viruses -- The first fact of comparative genomics: protein sequences are remarkably resilient in evolution -- The second fact of comparative genomics: functional convergence at the molecular level -- Prediction of function and reconstruction of metabolism from genomic data: homology-based approaches -- Prediction of function and reconstruction of metabolism: post-homology approaches -- Structural genomics: what does it tell us about life? -- How many protein families are there? -- Phylogenetic inference and the era of complete genomes -- Two stories about evolution -- Minimal and ancestral genomes -- Comparative genomics and systems biology.
- 1975. Google BooksFulltext (v. 2 pt. 1 1975) Google BooksFulltext (v. 2 pt. 2 1975) Google BooksFulltext (v. 3 1975) Google Booksgeneral editors, Melvin Calvin and Oleg G. Gazenko.Also available: Print – 1975.
- 2006 Springeredited by Semyon Slobounov, Wayne Sebastianelli.
- 2008 Springerby Semyon M. Slobounov.I. Foundations of Injury in Athletics -- Classification of Injuries in Athletics, p. 3-23 -- Science of Training and Injury in Athletics, p. 25-43 -- Balance as a Risk Factor for Athletic Injuries, p. 45-75 -- Fatigue-Related Injuries in Athletes, p. 77-95 -- Nutrition as a Risk Factor for Injury in Elite Athletes, p. 97-109 -- II. Coaches and Athletes' Perspectives of Injury -- Injury in Athletics: Coaches' Point of View, p. 113-146 -- Injury from Athletes' Perspectives, p. 147-159 -- Interviews with Injured Athletes, p. 161-195 -- Overuse Injuries: Students' Points of View, p. 197-216 -- Fitness Assessment in Athletes, p. 217-239 -- III. Psychological Traumas in Athletes -- Psychological Trauma: Unfortunate Experience in Athletics, p. 243-267 -- Fear as Adaptive or Maladaptive Form of Emotional Response, p. 269-287 -- Fear of Injury, Kinesiophobia & Perceived Risk, p. 289-309 -- Multiple Facets of Pain due to Injury, p. 311-330 -- Psychological Trauma: Case Studies, p. 331-355 -- Psychological Trauma: Age & Gender Factors, p. 357-374 -- IV. Concussion in Athletes -- Concussion: Why Bother?, p. 377-398 -- Concussion Classification: Historical Perspectives and Current Trends, p. 399-414 -- Evaluation of Concussion: Signs and Symptoms, p. 415-445 -- Traumatic Brain Injuries in Children, p. 447-466 -- V. Injury Rehabilitation -- Integrated Injury Rehabilitation, p. 469-491 -- EEG & Neurofeedback in Rehabilitation, p. 493-513 -- Virtual Reality in Injury Rehabilitation, p. 515-540.
- 2008 SpringerDavid M. Williams, Malte C. Ebach ; foreword by Gareth Nelson.Introduction: Systematics, evolution, and classification -- Systematics as problem solving -- The archetype -- Ernest Haeckel and systematische phylogenie -- The German development of morphology: from Ernest Haeckel to Willie Hanning -- Pattern Cladistics -- Homologues and homology -- Discovering homologues -- Homology and systematics -- Homology and transformation -- Character conflict -- The analyses of relationships -- Biogeograhical relationships, evolution, and classification.
- 2008 SpringerJessica Livingston.Max Levchin (PayPal) -- Sabeer Bhatia (Hotmail) -- Steve Wozniak (Apple Computer) -- Joe Kraus (Excite) -- Dan Bricklin (Software Arts) -- Mitchell Kapor (Lotus Development) -- Ray Ozzie (Iris Associates, Groove Networks) -- Evan Williams (Pyra Labs (Blogger.com) -- Tim Brady (Yahoo) -- Mike Lazaridis (Research In Motion) -- Arthur Van Hoff (Marimba) -- Paul Buchheit (Gmail) -- Steve Perlman (WebTV) -- Mike Ramsay (TiVo) -- Paul Graham (Viaweb) -- Joshua Schachter (del.icio.us) -- Mark Fletcher (ONElist, Bloglines) -- Craig Newmark (craigslist) -- Caterina Fake (Flickr) -- Brewster Kahle (WAIS, Internet Archive, Alexa Internet) -- Charles Geschke (Adobe Systems) -- Ann Winblad (Open Systems, Hummer Winblad) -- David Heinemeier Hansson (37signals) -- Philip Greenspun (ArsDigita) -- Joel Spolsky (Fog Creek Software) -- Stephen Kaufer (TripAdvisor) -- James Hong (HOT or NOT) -- James Currier (Tickle) -- Blake Ross (Firefox) -- Mena Trott (Six Apart) -- Bob Davis (Lycos) -- Ron Gruner (Alliant Computer Systems, Shareholder.com) -- Index.
- Greenberg, Paul.
- 2011 WHO"WHO's third decade was characterized by a sense of optimism, perhaps naive in retrospect. There was a feeling that progress was possible, not only in health, but in social and economic ways to improve individual and collective well-being. This optimism was reflected in the approval by the Thirtieth World Health Assembly in May 1977 of resolution WHA30.43, which stated that WHO's main social target for the coming decades should be for all citizens of the world to attain by the year 2000 a level of health to enable them to lead socially and economically productive lives."--Introduction, p. vii.
- 2008edited by Thomas L. Lemke, David A. Williams ; assistant editors, Victoria F. Roche, S. William Zito.
- 2012 AtyponThanh M. Cabral and Rangaraj M. Rangayyan.Fractal analysis is useful in digital image processing for the characterization of shape roughness and gray-scale texture or complexity. Breast masses present shape and gray-scale characteristics in mammograms that vary between benign masses and malignant tumors. This book demonstrates the use of fractal analysis to classify breast masses as benign masses or malignant tumors based on the irregularity exhibited in their contours and the gray-scale variability exhibited in their mammographic images. A few different approaches are described to estimate the fractal dimension (FD) of the contour of a mass, including the ruler method, box-counting method, and the power spectral analysis (PSA) method. Procedures are also described for the estimation of the FD of the gray-scale image of a mass using the blanket method and the PSA method.
- 2016 SpringerAntonio Di Ieva, editor.
- 2013 SpringerAnirban Banerji.Introduction -- Characterization of Protein-Protein Interfaces, Considering Surface-Roughness and Local Shape -- Adhesion on Protein (and Other Rough Biomolecular) Surfaces.
- 2013 SpringerAnirban Banerji.Introduction -- Characterization of Protein-Protein Interfaces, Considering Surface-Roughness and Local Shape -- Adhesion on Protein (and Other Rough Biomolecular) Surfaces.
- 2006 SpringerSeyed Behrooz Mostofi.
- 2012 SpringerSeyed Behrooz Mostofi.Residents and junior doctors on rotation are under constant pressure to have accurate and up-to-date information available to them. This is never more important than when on rotation in the Emergency Room. Junior doctors often lack experience in orthopaedics making the recognition and accurate identification of fractures and their treatment a challenging task.The second edition of this comprehensive handbook contains a wealth of illustrations and explanatory text, which is organized into a concise repository of information on fractures according to the most widely used classification systems. The classification systems covered include AO and OTA systems. This allows readers the opportunity to make a correct diagnosis using the appropriate criteria, while simplifying the planning of further management and ensuring that communication with experienced staff is more effective.
- 2013 SpringerEmmanuel Apergis ; foreword by Hisao Moritomo.According to reports in the literature, despite the severe disruption of carpal anatomy, fracture-dislocations of the wrist are missed on clinical and radiographic examination in a high percentage of cases. Orthopedic surgeons' lack of familiarity with these injuries is one of the factors contributing to failed or delayed diagnosis. This richly illustrated book covers all types of wrist dislocation and fracture-dislocation. Detailed information is provided on anatomy and biomechanics, while terminology and classification of injuries are explained. Treatment options are thoroughly analysed, with special emphasis on surgical treatment, which is presented step by step. All of the figures -- radiological and surgical -- relate to patients treated by the author himself. Most of the cases are from the Red Cross Hospital of Athens that admits many patients with such injuries, in part through referral from other centres due to the author's acknowledged expertise in the field. This volume, with its highly informative and up-to-date chapters and reviews, and a wealth of color figures, will be of great practical value for clinicians and residents in orthopedic surgery, who assist them in daily decision making.
- 2012 ClinicalKeyM. Patrice Eiff, Robert Hatch ; Mariam K. Higgins, medical illustrator.The 3rd edition provides the guidance you need to evaluate and treat common fractures, as well as identify uncommon fractures that should be referred to a specialist. Drs. M. Patrice Eiff and Robert Hatch emphasize the current best guidelines for imaging and treating fractures so that you can make accurate identifications and select appropriate treatment. Detailed descriptions and illustrations combined with evidence-based coverage give you the confidence you need to make the right decisions. Reference key information quickly and easily thanks to one-page management tables that summarize pertinent aspects of diagnosis and treatment. Reference key information quickly and easily thanks to one-page management tables that summarize pertinent aspects of diagnosis and treatment. Effectively manage emergency situations using guidelines for emergent referral, greater detail regarding methods for closed reductions for fractures and dislocations, and more. Know how and when to treat fractures and when to refer your patients to a specialist.
- 1958.Arnesen, Arne.Contents -- pt. 2. A contribution to the discussion on the treatment of calcaneus fracture based on an analysis of a ten-year material treated by closed reduction and traction, from Sentralsykehuset i Trondheim.
- 2009 ClinicalKey[edited by] David J. Slutsky, A. Lee Osterman.Recognized experts from around the world bring you "cutting-edge" guidance on the treatment of distal radius fractures and carpal injuries. Practical and comprehensive, you'll find detailed coverage of the treatment and causes of ulnar sided wrist pain, as well as the latest arthroscopic and mini-invasive techniques for the fixation of both distal radius fractures and scaphoid fractures. The user-friendly format features practical tips, pearls, and potential pitfalls to help optimize outcomes. Best of all, intraoperative videos of 44 techniques available on DVD and online make this an outstanding multimedia guide for the treatment of these challenging fractures. Uses real cases to illustrate diagnostic decision-making, nonsurgical and surgical management and care, and outcomes measurement for a variety of complex distal radius fractures, as well as 44 videos, over two hours, of procedures all on the DVD and website. Includes the fully-searchable text online for quick and easy access to the information you need. Covers distal radius fractures from imaging and classification to the new locking plate designs, emerging nonplate alternatives such as intramedullary and T-pin fixation, and newer nonbridging external fixators for intra-articular fractures to provide you with the latest developments in the field. Presents material in a concise, practical format for an ideal review before surgery. Provides a visual display of intraoperative procedures through full-color images and photographs. Features additional chapters, Role of Advanced Imaging in Distal Radius Fractures, Patient-focused Wrist Outcome Instrument, Biomechanics and Biology of Plate Fixation of Distal Radius Fractures, Micronail, Rehabilitation Following Distal Radius Fractures: a biomechanical/procedure specific approach, Use of Thermal Shrinkage: Biology and applications, Arthroscopic Thermal Shrinkage for Scapholunate Ligament Injuries, Rehabilitation following Carpal Injury, Reconstruction of the Distal Radius Facet by a Free Vascularized Ostechondral Graft, online for even more value.
- 2011 SpringerRobert J. Pignolo, Mary Ann Keenan, Nader M. Hebela, editors.Pt. 1. The aging of bone and etiologies of fractures -- pt. 2. Perioperative management -- pt. 3. Common fractures in the elderly -- pt. 4. Rehabilitation, post-fracture evaluation, and prevention.
- Fractures of the pelvis and acetabulum : principles and methods of management. Fourth edition [4th ed.].v.1-2=, 2015 Thieme-Connect[editors] Marvin Tile, David L. Helfet, James F. Kellam, Mark Vrahas.The fourth edition of this well-known and highly regarded book by Marvin Tile et al. is now a two-volume set of books based on the AO principles of operative management of fractures, as applied to the pelvis and acetabulum. With the collaboration of over 80 international expert surgeons and through hundreds of images and illustrations, each volume emphasizes decision making based on the assessment of the personality of the injury through the patients history, physical examination, and interpretation of radiographic investigations. Access to video presentations demonstrating surgical approaches.
- 2011 ClinicalKey[edited by] James P. Waddell.Match pre-operative assessment, surgical techniques, post-operative management, and more to the specific lifestyle factors of each patient in order to achieve optimal results. Apply state-of-the-art techniques and protocols with the visual help of operative videos as well as more than 500 surgical line drawings and photographs in print. Review surgical techniques such as pinning, plating/intramedulary devices, and total hip replacement implants, and get a greater understanding of deep vein thrombosis and pulmonary embolism prevention. Brush up on related topics including epidemiology, osteoporosis, co-morbidities, evidence-based post-op, and rehabilitation protocols. Get the advice of expert contributors worldwide who detail best practices in prophylaxis, surgical technique, and rehabilitation.
- 2015 SpringerPeter Biberthaler, Chlodwig Kirchhoff and James P. Waddell, editors.In this book fractures of the proximal humerus are examined in detail, with an overview of fracture morphology, injury pattern, preoperative considerations, conservative treatment, surgical management and postoperative care. It is organized anatomically, with a clear structure based on the most recent scientific data to allow surgeons to quickly access key information, practical aspects, pearls and pitfalls. The book is written by a group of experts from the Association for the Rationale Treatment of Fractures (ARTOF) who aim to provide an independent, unbiased summary of proximal humerus fracture treatments to improve clinical outcomes. Trauma and orthopaedic surgeons worldwide who are searching for current knowledge of new implants, therapeutic strategies and advancements will be able to quickly and accurately apply the information from this book to provide the best possible care for their patients.
- 2016 SpringerNirmal C. Tejwani, editor.Part 1: Treatment of Proximal Tibia articular fractures -- Schatzker I/II Tibia Plateau Fracture -- Schatzker III Tibia Plateau Fracture (with Bone Graft Substitute) -- Schatzker IV Tibia Plateau Fracture Treated with Open Reduction and Internal Fixations -- Bicondylar Tibial Plateau ORIF Technique -- Bicondylar Tibial Plateau Fracture (Schatzker VI) -- Tibial Plateau Schatzker V/VI Treated in Ex Fix/Circular Frame -- Bicondylar Tibial Plateau Fracture with Compartment Syndrome -- Part 2: Treatment of Tibia shaft fractures -- Proximal Third Tibia Fracture treated with Intramedullary Nailing -- Proximal Tibia Fracture Treated with Plate and Screws -- Mid Shaft Tibia Shaft Fracture Treated with Intra-medullary Nail (IMN) -- Tibia Shaft Distal Third: Treatment with an Intramedullary Nail -- Distal Tibia Shaft Fracture Treated with Plate Fixation -- Tibia Shaft Fractures of the Distal Third Treated with Plate Fixation of Tibia and Fibula -- Part 3. Treatment of Open Tibia fractures -- Open Tibia fractures: Staged treatment -- Open Tibial Fracture with Immediate Fixation and Early Soft Tissue Coverage -- Part 4: Treatment of Distal tibia articular fractures -- Distal Tibia Pilon: Staged Fixation with an Anterolateral Plate -- Distal tibial pilon fracture: Delayed Treatment and Dual Incision Approach -- Treatment of Pilon Fracture in External Fixator -- Distal Tibia Pilon: Staged Fixation -- Fibula Fixation and then Tibia -- Part 5: Treatment of Nonunion and mal-union of tibia fractures -- Nonunion Tibia Shaft treated with IMN/Bone Grafting -- Technique of Masquelet Bone Grafting -- Modified Clamshell Osteotomy for Treating Acute Tibial Shaft Fracture with Pre-existent Malunion -- Treatment of Tibia Malunion with Circular External Fixation -- Index.
- 2013Grazyna Jasienska.If reproductive hormones are so important, why is there so much variation? -- Coevolution of biology and culture : agriculture and selection for high levels of estrogens -- You are what you eat ... as a fetus -- The French paradox : did child welfare reduce the risk of heart disease? -- Intergenerational echoes of slavery -- The price of reproduction -- The ultimate test of costs of reproduction : life span -- Evolutionary past and modern diet -- Evolution and physical activity -- Evolutionary trade-offs and culture -- Fallacies of philanthropy -- Fixing genes versus fixing lifestyles.
- 2010 SpringerFlora Tassone, Elizabeth M. Berry-Kravis, editors.Clinical Neurological Phenotype of FXTAS / Maureen A. Leehey, Elizabeth Berry-Kravis, Christopher G. Goetz and Randi J. Hagerman -- The Epidemiology of FXTAS / Deborah A. Hall and Sebastien Jacquemont -- FXTAS: Neuropsychological/Neuropsychiatric Phenotypes / Jim Grigsby, Angela G. Brega, Andreea L. Seritan and James A. Bourgeois -- Radiological Findings in FXTAS / Susan M. Rivera, Glenn T. Stebbins and Jim Grigsby -- The Pathology of FXTAS / Claudia M. Greco, Michael R. Hunsaker and Robert F. Berman -- The Molecular Biology of FXTAS / Flora Tassone and Paul J. Hagerman -- Genotype/Phenotype Relationships in FXTAS / Emily Allen, Maureen A. Leehey, Flora Tassone and Stephanie Sherman -- Animal Models for FXTAS / Rob Willemsen, Yujing Li, Robert F. Berman, Judith R. Brouwer and Ben A. Oostra, et al. -- Treatment and Management of FXTAS / Elizabeth Berry-Kravis, Deborah A. Hall, Maureen A. Leehey and Randi J. Hagerman -- Genetic Counseling for FXTAS and FMR1-Associated Disorders / Louise W. Gane, Katherine Howard and Liane Abrams.
- 2011 ScienceDirectedited by Lawrence C. Kuo.There are numerous excellent reviews on Fragment Based Drug Discovery (FBDD), but there are to date no hand-holding guides or protocols with which one can embark on this orthogonal approach to complement traditional high throughput screening methodologies. This Methods in Enzymology volume offers the tools, practical approaches, and hit-to-lead examples on how to conduct FBDD screens. The chapters in this volume cover methods that have proven to be successful in generating leads from fragments, including chapters on how to apply computational techniques, nuclear magnetic resonance, surface plasma resonance, thermal shift and binding assays, protein crystallography, and medicinal chemistry in FBDD. Also elaborated by experienced researchers in FBDD are sample preparations of fragments, proteins, and GPCR as well as examples of how to generate leads from hits. Offers the tools, practical approaches, and hit-to-lead examples on how to conduct FBDD screens. The chapters in this volume cover methods that have proven to be successful in generating leads from fragments, including chapters on how to apply computational techniques, nuclear magnetic resonance, surface plasma resonance, thermal shift and binding assays, protein crystallography, and medicinal chemistry in FBDD.
- 2015 Springer Protocolsedited by Anthony E. Klon.Solvation methods for protein-ligand docking / Rachelle J. Bienstock -- Binding site druggability assessment in fragment-based drug design / Yu Zhou and Niu Huang -- Generating "fragment-based virtual library" using pocket similarity search of ligand-receptor complexes / Raed S. Khashan -- Virtual fragment preparation for computational fragment- based drug design / Jennifer L. Ludington -- Fragment library design : using cheminformatics and expert chemists to fill gaps in existing fragment libraries / Peter S. Kutchukian ... [et al.] -- Protocol for fragment hopping / Kevin B. Teuscher and Haitao Ji -- Site identification by ligand competitive saturation (SILCS) simulations for fragment-based drug Design / Christina E. Faller ... [et al.] -- Computational fragment-based de novo design protocol guided by ligand efficiency indices (LEI) / Álvaro Cortés-Cabrera, Federico Gago, and Antonio Morreale -- Scoring functions for fragment-based drug discovery / Jui-Chih Wang and Jung-Hsin Lin -- Computational methods for fragment-based ligand design : growing and linking / Rachelle J. Bienstock -- Design strategies for computational fragment-based drug design / Zenon D. Konteatis -- Protein binding site analysis for drug discovery using a computational fragment-based method / Jennifer L. Ludington -- Fragment-based design of kinase inhibitors : a practical guide / Jon A. Erickson -- Designing a small molecule erythropoietin mimetic / Frank Guarnieri -- Designing an orally available nontoxic p38 inhibitor with a fragment-based strategy / Frank Guarnieri.
- 2008 SpringerPeter J. Adams.PART 1: THEORY -- Addiction in Perspective -- Dangerous Consumptions -- Overview of this Book -- Companion Relationships -- A Social World -- Worlds, Paradigms and Assumptions -- The Particle Paradigm -- The Social Paradigm -- Switching to a Social World -- Addiction and Connecting -- Connecting to the World -- Patterns of Fragmentation -- Responding to Addiction -- The Prospect of Change -- Setting Out and Setting Back -- Making it Stick -- PART 2: PROCESSES -- Becoming Intimate -- Living in Relationships -- Intimacy and the "Four Cs" -- Special Considerations -- Quality Intimacy? -- Intimacies in Addictive Contexts -- Intimacy within Addictive Relationships -- Intimacies for Others -- Systems of Intimate Connections -- Intimacy and Power -- Controlling Tactics -- The Myth of Disinhibition -- Violence as a Social Event -- Managed Intimacy -- PART 3: FAMILIES & COMMUNITIES -- Fragmented Lives -- Fragmenting Environments -- How Intimates Respond -- Broader Social Dynamics -- Collective Opportunities -- Empowerment and Connectedness -- Reconnecting Intimates -- Responsibility for Change -- Change Processes -- Guidelines for Effective Collective Action -- Reintegration -- What is Reintegration? -- Six Phases of Reintegration -- Reforming Intimacies -- Enabling Closeness and Compassion -- Domains of Connectedness -- PART 4: APPLICATIONS -- Family Resources -- Social Resources from Inner Power -- Social Resources Offered by Services -- Mobilizing Communities -- Volunteer Networks -- Croatian/Italian Community Clubs -- An Indigenous Approach -- Applications to Practice -- Barriers to Social Inclusive Practice -- Social Engagement -- Social Assessment -- Facilitative Meetings -- Looking Ahead -- Where It Fits -- Future Opportunities
- 2015 Kargereditors, Roger A. Fielding, Cornel Sieber, Bruno Vellas.Connecting age-related biological decline to frailty and late-life vulnerability / J.D. Walston -- Cellular senescence and the biology of aging, disease, and frailty / N.K. LeBrasseur, T. Tchkonia, J.L. Kirkland -- The role of genome instability in frailty : mitochondria versus nucleus / A.Y. Seo, C. Leeuwenburgh -- Determinants of frailty and longevity : are they the same ones? / L. Rodrguez Maas -- A summary of the biological basis of frailty / R.A. Fielding -- Psychological frailty in the aging patient / L.J. Fitten -- Frailty clinical phenotype : a physical and cognitive point of view / M. Aubertin-Leheudre, A.J. Woods, S. Anton, R. Cohen, M. Pahor -- Overlaps between frailty and sarcopenia definitions / T. Cederholm -- Recovery after hip fracture : interventions and their timing to address deficits and desired outcomes : evidence from the Baltimore hip studies / J. Magaziner, N. Chiles, D. Orwig -- Physical exercise as therapy for frailty / L.E. Aguirre, D.T. Villareal -- Implementing frailty in clinical practice / M. Cesari, B. Vellas -- Implementing frailty into clinical practice for older adults at risk of dependency / B. Vellas.
- 2015 Kargervolume editors, Olga Theou, Kenneth Rockwood.Frailty : scaling from cellular deficit accumulation? / Rockwood, K.; Mitnitski, A. ; Howlett, S.E -- Assessment of frailty in animal models / Howlett, S.E. -- Frailty, inflammation, and immunosenescence / Fulop, T. ; McElhaney, J., Pawelec, G. ; Cohen. A.A ; Morais, J.A. ; Dupuis, G. ; Baehl, S. ; Camous, X. ; Witkowski, J.M. ; Larbi, A. -- Sex differences in frailty / Hubbard, R.E. -- Frailty and the microbiome / Meehan, C.J. ; Langille, M.G.I. ; Beiko, R.G. -- Operationalizing frailty using the frailty phenotype and deficit accumulation approaches / Theou, O. ; Walston, J. ; Rockwood, K. -- Comparison and clinical applications of the frailty phenotype and frailty index approaches / Theou, O. ; Rockwood, K. -- Frailty in primary care / Romero-Ortuno, R. -- Hospital care for frail elderly adults : from specialized geriatric units to hospital-wide interventions / Bakker, F.C. ; Olde Rikkert, M.G.M. -- Frailty and mobility / Eeles, E. ; Low Choy, N. -- Frailty and interprofessional collaboration / Briggs, M.C.E. ; McElhaney, J.E. -- Frailty and rehabilitation / Cameron, I.D. ; Kurrle, S.E. -- End of life care in frailty / Moorhouse, P. ; Koller, K. ; Mallery, L. -- Frailty and organization of health and social care / Clegg, A. ; Young, J. -- Frailty's place in ethics and law : some thoughts on equality, autonomy, and limits and on possibilities for aging citizens / McNally, M.; Lahey, W. -- Frailty and social vulnerability / Andrew, M.K.
- 2008 SpringerLuc Duchateau and Palul Janssen.
- 2011 CRCnetBASEAndreas Wienke.The concept of frailty offers a convenient way to introduce unobserved heterogeneity and associations into models for survival data. In its simplest form, frailty is an unobserved random proportionality factor that modifies the hazard function of an individual or a group of related individuals. Frailty Models in Survival Analysis presents a comprehensive overview of the fundamental approaches in the area of frailty models. The book extensively explores how univariate frailty models can represent unobserved heterogeneity. It also emphasizes correlated frailty models as extensions of univariate and shared frailty models. The author analyzes similarities and differences between frailty and copula models; discusses problems related to frailty models, such as tests for homogeneity; and describes parametric and semiparametric models using both frequentist and Bayesian approaches. He also shows how to apply the models to real data using the statistical packages of R, SAS, and Stata. The appendix provides the technical mathematical results used throughout. Written in nontechnical terms accessible to nonspecialists, this book explains the basic ideas in frailty modeling and statistical techniques, with a focus on real-world data application and interpretation of the results. By applying several models to the same data, it allows for the comparison of their advantages and limitations under varying model assumptions. The book also employs simulations to analyze the finite sample size performance of the models.--From the publisher's website.
- 2016Committee on Educating Health Professionals to Address the Social Determinants of Health, Board on Global Health, Institute of Medicine, National Academies of Sciences, Engineering, and Medicine."The World Health Organization defines the social determinants of health as "the conditions in which people are born, grow, work, live, and age, and the wider set of forces and systems shaping the conditions of daily life." These forces and systems include economic policies, development agendas, cultural and social norms, social policies, and political systems. In an era of pronounced human migration, changing demographics, and growing financial gaps between rich and poor, a fundamental understanding of how the conditions and circumstances in which individuals and populations exist affect mental and physical health is imperative. Educating health professionals about the social determinants of health generates awareness among those professionals about the potential root causes of ill health and the importance of addressing them in and with communities, contributing to more effective strategies for improving health and health care for underserved individuals, communities, and populations. Recently, the National Academies of Sciences, Engineering, and Medicine convened a workshop to develop a high-level framework for such health professional education. A Framework for Educating Health Professionals to Address the Social Determinants of Health also puts forth a conceptual model for the framework's use with the goal of helping stakeholder groups envision ways in which organizations, education, and communities can come together to address health inequalities"--Publisher's description.
- Francisella tularensis host-pathogen relationships : dissecting bacterial interactions with the Drosophila innate immune system2010Madeleine Moule.The survival of a bacterial pathogen within a host depends upon its ability to outmaneuver the host immune response. Thus mutant pathogens provide a useful tool for dissecting host-pathogen relationships as the strategies the microbe has evolved to counteract immunity reveal a host's immune mechanisms. In this study, we examined the pathogen Francisella tularensis subspecies novicida and identified new bacterial virulence factors that interact with different parts of the Drosophila melanogaster innate immune system. We performed a genome-wide screen to identify F. novicida genes required for growth and survival within the fly and identified a set of 149 negatively selected mutants. Among these, we identified a class of genes including the transcription factor oxyR, and the DNA repair proteins uvrB, recB, and ruvC that help F novicida resist oxidative stress. We determined that these bacterial genes are virulence factors that allow F. novicida to counteract the fly melanization immune response. We then performed a second in vivo screen to identify an additional subset of bacterial genes that interact specifically with the imd signaling pathway. Most of these mutants have decreased resistance to the antimicrobial peptide polymyxin B. Characterization of a mutation in the putative transglutaminase FTN_0989 produced a curious result that could not easily be explained using known Drosophila immune responses. By using an unbiased genetic screen, these studies provide a new view of the Drosophila immune response from the perspective of a pathogen. We show that two branches of the fly's immunity are important for fighting F. novicida infections in a model host: melanization and an imd-regulated immune response, and identify bacterial genes that specifically counteract these host responses. Our work suggests that there may be more to learn about the fly immune system as not all of the phenotypes we observe can be readily explained by its interactions with known immune responses.
- 2011 CambridgeAidan Shaw, Benjamin Smith, David C. Howlett.An essential revision tool for the FRCR anatomy examination, including 10 mock examinations and 200 images, comprehensively covering the curriculum.
- 2011 Kargervolume editors, Yuji Naito, Makoto Suematsu, Toshikazu Yoshikawa.Free radicals and lipid peroxidation / Niki, E. -- Mitochondria as source of free radicals / Majima, H.J. ... [et al.] -- The Nox family of NADPH oxidases that deliberately produce reactive oxygen species / Sumimoto, H., Minakami, R., Miyano, K. -- Neutrophil-dependent oxidative stress in inflammatory gastrointestinal diseases / Naito, Y., Yoshikawa, T. -- Oxidative DNA damage and carcinogenesis / Jiang, L., Toyokuni, S. -- Plasma marker of oxidative stress in circulation and in tissue / Yamamoto, Y. -- Immunochemical detection of 4-hydroxy-2-nonenal-specific epitopes / Uchida, K. -- Carbon monoxide-dependent regulation of microvascular function : one gas regulates another / Suematsu, M., Kajimura, M., Kabe, Y. -- Nrf2-Keap1 signaling as a prime chemopreventive target for antioxidative and anti-inflammatory phytochemicals / Surh, Y.-J. -- Free radicals and gastric mucosal injury / Ock, C.Y. ... [et al.] -- Free radicals in helicobacter pylori infection / Suzuki, H. ... [et al.] -- Free radical and nonsteroidal anti-inflammatory drug-induced small intestinal injury / Handa, O., Naito, Y. -- Free radicals in inflammatory bowel disease / Takagi, T., Naito, Y., Yoshikawa, T. -- Free radicals and chronic hepatitis C / Sakaida, I -- Free radicals and nonalcoholic fatty liver disease/nonalcoholic steatohepatitis / Sumida, Y., Naito, Y., Yoshikawa, T. -- Role of free radicals in pancreatitis / Hamada, S., Shimosegawa, T. -- Free radicals and cancer treatment / Kokura, S.
- 2006 SpringerClemens von Sonntag.
- 2007Barry Halliwell and John M.C. Gutteridge.
- 2009. ScienceDirectedited by T.W.J. Gadella.
- 2012 SpringerRobert W. Rieber ; with contributions by David Bakan."In its early days, some saw psychology as a substitute for religion. Others regarded it as a new religion in its own right. What was less obvious to most observers--and far less obvious today--were the roots of Freud's work in the ancient mystical teachings of the Middle East. A unique analysis, Freud on Interpretation examines the inner workings of his thought process and the rich mine of knowledge that led him toward his theories and therapies. In the beliefs of ancient Egypt, with its sexually ambiguous dieties, and ancient Israel, with its Biblical accounts of madness and feigned madness, are found surprising sources of inspiration for such core Freudian concepts as free association, dream interpretation, the psychosexual stages, the libido, and the unconscious. Psychoanalyis here is seen in its early growth stages, fed and nurtured by philosophers, scientists, and fearless mind explorers; and Freud is boldly synthesizing modes of knowledge from an age when science and superstition were rarely separate. This compelling volume: Overviews the pre-Freudian history of psychology in the writings of Herbart, Morel, and Krafft-Ebing; Probes Freud's interest in ancient Egyptian creation myths and the Kabbala, and their influence on his work; Explores the paradoxes inherent in the interpretation of the mind; Offers unique insights into the origins of the Rorschach test; Considers the real meaning behind Freud's self-identification as a determinist; Includes a listing of Freud's library of titles on ancient Egypt; Freud on Interpretation is stimulating reading for clinical psychologists and those interested in the intellectual and professional development of the master psychiatrist."--Publisher's website.
- Freyschmidt's "Koehler/Zimmer" Borderlands of normal and early pathologic findings in skeletal radiography. 5th revised edition.2003 MedlantisJuergen Freyschmidt, Joachim Brossmann, Juerger Wiens, Andreas Sternberg ; foreword by Donald Resnick.Also available: Print – 2003
- 2014Catherine Reef.Explores the tumultuous lives, marriage, and work of Mexican artists Frida Kahlo and Diego Rivera.
- 2007 ScienceDirectedited by C. von Hofsten, K. Rosander.Pt. I. The structuring of the brain -- Unaltered development of the archi- and neocortex in prematurely born infants: genetic control dominates in proliferation, differentiation and maturation of cortical neurons / H. Ábrahám ... [et al.] -- Subcortical regulation of cortical development: some effects of early, selective deprivations / G.M. Innocenti -- The mirror-neurons system: data and models / L. Craighero ... [et al.] -- Apraxia: a review / B. Petreska ... [et al.] -- Pt. II. The early development of perception and action -- Effects of early visual deprivation on perceptual and cognitive development / D. Maurer, C.J. Mondloch, T.L. Lewis -- Visual tracking and its relationship to cortical development / K. Rosander -- Visual and visuocognitive development in children born very prematurely / J. Atkinson, O. Braddick -- Development of brain mechanisms for visual global processing and object segmentation / O. Braddick, J. Atkinson -- How face specialization emerges in the first months of life / F. Simon ... [et al.] -- The early development of visual attention and its implications for social and cognitive development / S. Hunnius -- Pt. III. The development of action and cognition -- Visual constraints in the development of action / G. Savelsbergh ... [et al.] -- Object and event representation in toddlers / R. Keen, K. Shutts -- Learning and development in infant locomotion / S.E. Berger, K.E. Adolph -- Core Systems in human cognition / K.D. Kinzler, E.S. Spelke -- Taking an action perspective on infant's object representations / G. Gredebäck, C. von Hofsten -- Pt. IV. The development of action and social cognition -- Infants' perception and production of intentional actions / P. Hauf -- The role of behavioral cues in understanding goal-directed actions in infancy / S. Biro, G. Csibra, G. Gergely -- Seeing the face through the eyes: a developmental perspective on face expertise / T. Gliga, G. Csibra -- Past and present challenges in theory of mind research in nonhuman primates / J. Call -- Infancy and autism: progress, prospects, and challenges / M. Elasbbagh, M.H. Johnson -- Children-robot interaction: a pilot study in autism therapy / H. Kozima, C. Nakagawa, Y. Yasuda -- Pt. V. The development of artificial systems -- Sensorimotor coordination in a "baby" robot: learning about objects through grasping / L. Natale ... [et al.] -- Emergence and development of embodied cognition: a constructivist approach using robots / Y. Kuniyoshi ... [et al.].
- From animals to animats 10 : 10th International Conference on Simulation of Adaptive Behavior, SAB 2008, Osaka, Japan, July 7-12, 2008 : proceedings2008 SpringerMinoru Asada, John C.T. Hallam, Jean-Arcady Meyer, Jun Tani, editors.
- 2016 Kargervolume editors, Fu-Chan Wei, Hui-Yun Cheng, Cheng-Hung Lin.Microsurgical reconstruction in brachial plexus injury and facial paralysis / Chuang, D.C.-C. -- Microsurgical reconstruction of oncological defects / Cheng, M.-H.; Browne, T. -- Various free intestinal flaps and omentum for reconstruction of defects / Maruccia, M.; Chen, H.-C. -- Achieving norms : limitations of autotransplantation and the need for allotransplantation illustrated with head and neck reconstruction / Al Deek, N.F.; Tsao, C.-K.; Wei, F.-C. -- Evolution from toe-to-hand transfer to hand transplantation / Zelken, J.; Lin, C.-H. -- Vascularized covmposite allografts and solid organ transplants : similarities and differences / Weissenbacher, A.; Grahammer, J.; Hautz, T.; Schneeberger, S. -- Development of a clinical vascularized composite allotransplantation program : requirements and recommendations / Lawson, S.; Wang, L.; Fries, A.; Davis, M.; Gorantla, V.S. -- Hand transplantation / Brandacher, G.; Shores, J.T.; Lee, W.P.A. -- Facial transplantation / Aycart, M.; Alhefzi, M.; Kueckelhaus, M.; Fischer, S.; Dermietzel, A.; Wo, L.; Bueno, E.; Pomahac, B. -- Establishing a center for vascularized composite allotransplantation : the experience of Chang Gung Memorial Hospital / Cheng, H.-Y.; Al Deek, N.F.; Wei, F.-C. -- Development of animal models for the study of vascularized composite allotransplantation / Zelken, J.; Lin, C.-H. -- Induction of donor-specific tolerance with vascularized bone marrow transplantation / Lin, C.-H.; Anggelia, M.R. -- Cellular therapeutics-based strategies for inducing donor-specific tolerance to vascularized composite allotransplants / Cheng, H.-Y. -- In vivo bioimaging platform with tissomic validation for vascularized composite allotransplantation / Wen, C.-J.; Hsieh, Y.-H. -- Potential of microRNAs in vascularized composite allotransplantation / Hsieh, C.-H. -- Potential of induced pluripotent stem cells in vascularized composite allotransplantation / Wang, Y.-L..
- 2013 SpringerPaolo Marzullo, Guiliano Mariani, editors ; foreword by Philipp Kaufmann.The recent development of three-dimensional imaging techniques has provided an enormous amount of information relevant to the clinical management of patients at low and high risk for coronary artery disease. However, while progress in each individual technique has been rapid, the correlation of findings obtained with radiology, nuclear medicine, and magnetic resonance imaging is still relatively neglected. In this book, qualified experts in cardiac imaging present the basic concepts of cardiac disease and imaging and compare the findings obtained in particular subspecialties with those acquired using other techniques. In this way the reader will learn how images and techniques can be integrated in clinical practice to the benefit of the patient. In addition, the issue is addressed of reducing the patient's exposure to ionizing radiation through appropriate multimodality integration. Physicians ranging from cardiac surgeons to internal medicine specialists and even public health administrators will find this book invaluable in understanding the role of hybrid cardiac imaging.
- 2011 SpringerCarlos Hernández ... [et al.], editors.Introduction: From Brains to the Machines of the Future / Ricardo Sanz, Carlos Hernández and Jaime Gómez-Ramirez -- Emergent Feature Sensitivity in a Model of the Auditory Thalamocortical System / Martin Coath, Robert Mill, Susan L. Denham and Thomas Wennekers -- STDP Pattern Onset Learning Depends on Background Activity / James Humble, Steve Furber, Susan L. Denham and Thomas Wennekers -- Emergence of Small-World Structure in Networks of Spiking Neurons Through STDP Plasticity / Gleb Basalyga, Pablo M. Gleiser and Thomas Wennekers -- Coupling BCM and Neural Fields for the Emergence of Self-organization Consensus / Mathieu Lefort, Yann Boniface and Bernard Girau -- Alpha and Theta Rhythm Abnormality in Alzheimer's Disease: A Study Using a Computational Model / Basabdatta Sen Bhattacharya, Damien Coyle and Liam P. Maguire -- Oscillatory Neural Network for Image Segmentation with Biased Competition for Attention / Tapani Raiko and Harri Valpola -- Internal Simulation of Perceptions and Actions / Magnus Johnsson and David Gil -- Building Neurocognitive Networks with a Distributed Functional Architecture / Marmaduke Woodman, Dionysios Perdikis, Ajay S. Pillai, Silke Dodel and Raoul Huys, et al. -- Reverse Engineering for Biologically Inspired Cognitive Architectures: A Critical Analysis / Andreas Schierwagen -- Competition in High Dimensional Spaces Using a Sparse Approximation of Neural Fields / Jean-Charles Quinton, Bernard Girau and Mathieu Lefort -- Informational Theories of Consciousness: A Review and Extension / Igor Aleksander and David Gamez -- Hippocampal Categories: A Mathematical Foundation for Navigation and Memory / Jaime Gómez-Ramirez and Ricardo Sanz -- The Role of Feedback in a Hierarchical Model of Object Perception / Salvador Dura-Bernal, Thomas Wennekers and Susan L. Denham -- Machine Free Will: Is Free Will a Necessary Ingredient of Machine Consciousness? / Riccardo Manzotti -- Natural Evolution of Neural Support Vector Machines / Magnus Jändel -- Self-conscious Robotic System Design Process - From Analysis to Implementation / Antonio Chella, Massimo Cossentino and Valeria Seidita -- Simulating Visual Qualia in the CERA-CRANIUM Cognitive Architecture / Raúl Arrabales, Agapito Ledezma and Araceli Sanchis -- The Ouroboros Model, Selected Facets / Knud Thomsen.
- 2009Milica Margeta.
- From calcium channels to autism : effects of the Timothy Syndrome mutation in CaV1.2 on neuronal development2009Jocelyn Friedman Krey.L-type voltage-gated calcium channels (LTCs) play a key role in neuronal development by activating signalling pathways that regulate neuronal gene expression and morphology. A point mutation in the LTC CaV1.2, which blocks voltage-dependent inactivation (VDI), causes autism in Timothy Syndrome (TS) patients. While it is known how VDI influences the current through LTCs, it is not known how alterations in VDI affect the signaling function of CaV1.2 in neurons and ultimately cause developmental defects that lead to autism. Here I show that expression of CaV1.2 channels containing the TS mutation (TS-CaV1.2) inhibits CRE-dependent transcription and causes dendrite retraction and reduced dendrite branching in cortical neurons. I found that expression of TS-CaV1.2 leads to increased calcium influx in neurons and that this increase in intracellular calcium concentrations was in part responsible for the ability of TS-CaV1.2 channels to inhibit CREB. Surprisingly, however, I found that TS-CaV1.2 causes dendritic retraction independently of Ca2+ influx through the channel suggesting that the voltage-dependent conformational changes associated with VDI play an important and unexpected role in CaV1.2 signalling. In addition, I found that TS-CaV1.2 causes dendrite retraction by activating the RhoA signalling pathway. I found that changes in the interaction of the small GTP-binding protein Gem with the channel beta subunit play a critical role in mediating the activation of RhoA by TS-CaV1.2. These results provide new insight into how LTCs are coupled to cytoskeletal signalling pathways in neurons and shed light on the molecular mechanisms underlying the generation of TS and other Autism Spectrum Disorders.
- 2006 NAPCommittee on Cancer Survivorship: Improving Care and Quality of Life, National Cancer Policy Board ; Maria Hewitt, Sheldon Greenfield, and Ellen Stovall, editors.Cancer survivors -- The medical and psychological concerns of cancer survivors after treatment -- Delivering cancer survivorship care -- Providers of survivorship care: their supply and education and training -- Employment, insurance, and economic issues -- Research.
- 2014 Wileyedited by Simon Cohn."Presents a collection of international contributions that complement, as well as critique, dominant conceptualisations of health behaviour"--Provided by publisher.
- 2016 SpringerMatei Mancas, Vincent P. Ferrera, Nicolas Riche, John G. Taylor, editors."This both accessible and exhaustive book will help to improve modeling of attention and to inspire innovations in industry. It introduces the study of attention and focuses on attention modeling, addressing such themes as saliency models, signal detection and different types of signals, as well as real-life applications. The book is truly multi-disciplinary, collating work from psychology, neuroscience, engineering and computer science, amongst other disciplines. What is attention? We all pay attention every single moment of our lives. Attention is how the brain selects and prioritizes information. The study of attention has become incredibly complex and divided: this timely volume assists the reader by drawing together work on the computational aspects of attention from across the disciplines. Those working in the field as engineers will benefit from this book's introduction to the psychological and biological approaches to attention, and neuroscientists can learn about engineering work on attention. The work features practical reviews and chapters that are quick and easy to read, as well as chapters which present deeper, more complex knowledge. Everyone whose work relates to human perception, to image, audio and video processing will find something of value in this book, from students to researchers and those in industry"--Provided by publisher.
- 2006 SpringerB. Pulendran and R. Ahmed (eds.).TLR signaling / S. Akira -- Dendritic cells : translating innate to adaptive immunity / R.M. Steinman and H. Hemmi -- Helper T cell-regulated B cell immunity / L.J. Mcheyzer-Williams, L.P. Malherbe, and M.G. McHeyzer-Williams -- T cell memory / J.T. Tan an C.D. Surh -- The privacy of T cell memory to viruses / R.M. Welsh ... [et al.] -- Enhancement of infectious disease vaccines through TLR9-dependent recognition of CpG DNA / M.J. McCluskie and A.M. Krieg.
- From local invasion to metastatic cancer : involvement of distant sites through the lymphovascular system2009 Springeredited by Stanley P.L. Leong.
- 2014Elizabeth Ahrens-Kley, Gerald E. Trobough, Michael A. Shea.Hippocrates / by Michael A. Shea -- The Valley's First Practitioner / by Michael A. Shea -- An Ohlone Birth / by Michael A. Shea -- Trephination in History / by Michael A. Shea -- Bloodletting / by Michael A. Shea -- Medical Care at Mission Santa Clara / by Gerald E. Trobough-- Gold Rush Medicine / by Michael A. Shea -- John Marsh the First American Practitioner in California / by Michael A. Shea -- John Townsend, Pioneer Doctor / by Michael A. Shea -- Benjamin Cory and other Pioneer Physicians. Part 1, Isaac Isbell / by Gerald E. Trobough -- The Cory Brothers Modernized Medicine in Santa Clara County -- Pioneer Physician of Santa Clara Township. Dr. Henry H. Warburton (1819-1903) / by Gerald E. Trobough -- Benjamin Cory and other Pioneer Physicians. Part 2, Louis Bascom / by Gerald E. Trobough -- Benjamin Cory and other Pioneer Physicians. Part 3, Alexander Spencer / by Gerald E. Trobough -- Pioneer Physicians of Los Gatos / by Gerald E. Trobough -- Keeley Institute / by Gerald E. Trobough -- Here Come the Lady Physicians / by Michael Shea -- The Cholera Epidemic-San Jose California 1850 / by elizabeth Ahrens-Kley -- A Famous Grizzley Bear Attack in 1854 / by Michael A. Shea -- Orificial Surgery / by Michael A. Shea -- Origins of the Medical Societies / by Gerald E. Trobough -- American's Greatest Surgeon? / by Gerald E. Trobough -- First Hospital in San Jose by Gerald E. Trobough -- The History of O'Connor Hospital / by Michael A. Shea -- The History of San Jose Hospital / by Michael A. Shea -- Tuberculosis Hospitals of Santa Clara Valley by Gerald E. Trobough -- UCSF Medical School-- the Beginning / by Michael A. Shea -- The Origin of Stanford Medical School / by Michael A. Shea -- Levi Cooper Lane (1830-1902) / by Michael A. Shea -- Agnews State Hospital / by Michael A. Shea -- Leon Parish Fox, MD-- Man of the Century / by Michael A. Shea.
- 2006 Springeredited by Vincent J. Hearing, Stanley P.L. Leong.The origin and development of neural crest-derived melanocytes / Debra L. Silver and William J. Pavan -- MITF : a matter of life and death for the developing melanocytes / Heinz Arnheiter ... [et al.] -- MITF : critical regulator of the melanocyte lineage / Erez Feige, Laura L. Poling, and David E. Fisher -- Melanocytes and the transcription factor Sox10 / Michael Wegner -- Human cutaneous pigmentation : a collaborative act in the skin, directed by paracrine, autocrine, and endocrine factors and the environment / Zalfa A. Abdel-Malek and Ana Luisa Kadekaro -- Melanocyte distribution and function in human skin : effects of ultraviolet radiation / Yuji Yamaguchi and Vincent J. Hearing -- Altered signal transduction in melanoma / Pablo López Bergami, Anindita Bhoumik, and Ze'ev Ronai -- BRN2 in melanocytic cell development, differentiation, and transformation / Anthony L. Cook ... [et al.] -- The dynamic roles of cell-surface receptors in melanoma development / Dong Fang and Meenhard Herlyn -- Familial melanoma genes, melanocyte immortalization, and melanoma initiation / Dorothy C. Bennett -- Genetic progression from melanocyte to malignant melanoma / Boris C. Bastian -- The multiple roles of the oncogenic protein SKI in human malignant melanoma / Dahu Chen ... [et al.] -- RB/E2F regulation and dual activity in the melanocytic system / Ruth Halaban -- Melanoma development and pigment cell transformation / Claudia Wellbrock -- The biology and genetics of melanoma / Norman E. Sharpless and Lynda Chin -- The biology of xeroderma pigmentosum : insights into the role of ultraviolet light in the development of melanoma / James E. Cleaver -- Divergent pathways to cutaneous melanoma / David C. Whiteman and Adéle C. Green -- Pigmentation, DNA repair, and candidate genes : the risk of cutaneous malignant melanoma in a mediterranean population / Maria Teresa Landi -- Low-penetrance genotypes, pigmentation phenotypes, and melanoma etiology / Peter A. Kanetsky and Timothy R. Rebbeck -- The biology of melanoma progression : from melanocyte to metastatic seeds / A. Neil Crowson, Cynthia Magro, and Martin C. Mihm, Jr. -- Optical imaging analysis of atypical nevi and melanoma / Amanda Pfaff Smith and Dorothea Becker -- Proteomics analysis of melanoma cell lines and cultured melanocytes / Katheryn A. Resing and Natalie G. Ahn -- Paradigm of metastasis for malignant melanoma / Stanley P.L. Leong -- Repair of UV-induced DNA damage and melanoma risk / Qingyi Wei -- High risk factors for melanoma metastasis / Neil A. Accortt and Seng-jaw Soong -- Role of melanoma inhibitory activity in early development of malignant melanoma / Anja-Katrin Bosserhoff -- Role and regulation of PAR-1 in melanoma progression / Carmen Tellez and Menashe Bar-Eli -- Molecular mechanisms of melanoma metastasis / Mohammed Kashani-Sabet -- Overview of tumor progression in melanoma / David E. Elder -- The plasticity of melanoma cells and associated clinical implications / Mary J. C. Hendrix ... [et al.] -- The clinical use of molecular markers as predictors of disease outcome and response to therapy in malignant melanoma / Steve R. Martinez, Hiroya Takeuchi, Dave S.B. Hoon -- The role of DCT/TYRP2 in resistance of melanoma cells to drugs and radiation / Brian J. Pak and Yaacov Ben-David -- How melanoma cells evade chemotherapy : role of transporter-dependent and -independent resistance mechanisms / Kevin G. Chen and Michael M. Gottesman -- Apoptosis in melanoma: approaches to therapy / Heicke Röckmann and Dirk Schadendorf -- Role of melanoma-associated antigens / Rishab K. Gupta, Ana M. McElrath-Garza, and Donald L. Morton -- Host responses to melanoma : implications for immunotherapy / Julian A. Kim and Ernest Borden -- Future perspectives / Vincent J. Hearing and Stanley P.L. Leong.
- From molecular to modular tumor therapy : tumors are reconstructible communicatively evolving systems2010 SpringerAlbrecht Reichle, editor."The traditional problem of the poor presentability as well as diagnostic and therapeutic practicability of individual patient care is still unresolved. The present book aims at leading the reader (cancer researchers, pharmacologists, biologists) away-in a scientifically accessible manner-from the daily conflicts between theory and practice and between the generalized and individual tumor patient, so that more personalized diagnostic and therapeutic strategies can be developed for controlling metastatic tumor disease: First, recording the systems concept of tumor biology based on rather different sciences (biochemistry, cell biology, and medical oncology) including their potential contribution to communication, then, giving reductionistically derived systems features an internal communicative context (formal-pragmatic communication theory), and finally, binding the systems features to (tumor-immanent) evolutionary processes (modularity of biochemical and cellular processes, rationalization of biologic functions)"--Back cover.
- 2012 SpringerNatasha Maurits.1. Introduction -- 2. Carpal Tunnel Syndrome, Electroneurography, Electromyography, and Statistics -- 3. Tremor, Polymyography, and Spectral Analysis -- 4. Epilepsia, Electroencephalography, Filtering, and Feature Extraction -- 5. Multiple Sclerosis, Evoked Potentials, and Enhancing Signal-to-Noise Ratio -- 6. Cortical Myoclonus, EEG-EMG, Back-Averaging, and Coherence Analysis -- 7. Psychogenic Movement Disorders, Bereitschaftspotential, and Event-Related Potentials -- 8. Brain Tumor, Preoperative Function Localization, and Source Localization -- 9. Neuromuscular Diseases, Ultrasound, and Image Analysis -- 10. Cerebrovascular Disease, Ultrasound, and Hemodynamical Flow Parameters -- 11. Spinal Dysfunction, Transcranial Magnetic Stimulation, and Motor Evoked Potentials.
- From neuroscience to neurology : neuroscience, molecular medicine, and the therapeutic transformation of neurology2005 ScienceDirectedited by Stephen Waxman.1. Seeing the brain so we can save it: the evolution of magnetic resonance imaging as a clinical tool -- 2. Advances in the acute treatment and secondary prevention of stroke -- 3. Preserving function in acute nervous system injury -- 4. Slowing the progression of multiple sclerosis -- 5. The Emergence of neurosurgical approaches to the treatment of epilepsy -- 6. The Neurobiology of migraine and transformation of headache therapy -- 7. Botulinum toxins: transformation of a toxin into a treatment -- 8. Prospects for slowing the progression of Parkinson's disease -- 9. Current neurosurgical treatments for Parkinson's disease: where did they come from? -- 10. Treatable peripheral neuropathies: plasma exchange, intravenous immunoglobulin, and other emerging therapies -- 11. Molecular pharmacology and the treatment of Tourette's syndrome and attention deficit-hyperactivity disorder -- 12. Neuroscience, molecular medicine, and new approaches to the treatment of depression and anxiety -- 13. Genomics, proteomics, and neurology -- 14. Neuroprotection: where are we going? -- 15. Prospects for gene therapy for central nervous system disease -- 16. Therapeutics development for hereditary neurological diseases -- 17. Inherited channelopathies of the CNS: lessons for clinical neurology -- 18. Inherited channelopathies of muscle: implications for therapy -- 19. Transcriptional channelopathies of the nervous system: new targets for molecular medicine -- 20. New molecular targets for the treatment of neuropathic pain -- 21. Therapeutic transfer and regeneration of neural progenitors or neurons in gray matter of the adult brain -- 22. Cellular plasticity of the adult human brain -- 23. Harnessing endogenous stem cells for central nervous system repair -- 24. Neuropathies-translating causes into treatments -- 25. Therapeutic potential of neurotrophic factors -- 26. Promoting the regeneration of axons within the central nervous system -- 27. Alzheimer's disease: clinical features, neuropathological and biochemical abnormalities, genetics, models, and experimental therapeutics -- 28. Behavioral intervention and recovery from CNS damage -- 29. What functional brain imaging will mean for neurology.Also available: Print – 2005
- From non-coding RNAs to histone demethylases, identifying novel epigenetic regulators of the HOX loci in development and cancer2009Jordon Kuo-Ming Wang.
- 2012 SpringerVolker A. Erdmann, Jan Barciszewski, editors.RNAissance / Juergen Brosius -- Nucleic Acids as Therapeutics / Saraswat Pushpendra, Pareek Arvind and Bhandari Anil -- Thio Effects as a Tool for Mechanistic Studies of the Cleavage of RNA Phosphodiester Bonds: The Chemical Basis / Mikko Ora, Tuomas Lönnberg and Harri Lönnberg -- Off-Target Effects and Safety Aspects of Phosphorothioate Oligonucleotides / Martina Stessl, Christian R. Noe and Johannes Winkler -- Oligonucleotide Conjugates: Rationale, Synthesis, and Applications / Yashveer Singh, Pierre Murat, Nicolas Spinelli and Eric Defrancq -- CRISPR: A Bacterial Immunity System Based on Small RNAs / Rolf Wagner and Ümit Pul -- Antisense Technology: From Unique Laboratory Tool to Novel Anticancer Treatments / Christine Di Cresce, Colin Way, Mateusz Rytelewski, Saman Maleki Vareki and Supritha Nilam, et al. -- Antisense-Mediated Reduction of Eukaryotic Noncoding RNAs / Xue-hai Liang, Timothy A. Vickers and Stanley T. Crooke -- Antisense Oligonucleotides in the Treatment of Malignant Gliomas / Gerardo Caruso, Mariella Caffo, Giuseppe Raudino, Federica Raudino and Mario Venza, et al. -- Natural Antisense Transcripts Mediate Regulation of Gene Expression / Marco Magistri and Mohammad Ali Faghihi -- Activation and Deactivation of Antisense and RNA Interference Function with Light / Jeane M. Govan and Alexander Deiters -- Ribozymes as Molecular Biology Reagents / Sanchita Bhadra, Arti Pothukuchy and Andrew Ellington -- RNA Technologies for Mitochondrial Genetics / André Dietrich, Katarzyna Rolle, Marta Gabryelska, Eliza Wyszko and Romain Val, et al. -- RNA-Based Therapies for Inherited Metabolic Diseases / Belén Pérez, Magdalena Ugarte and Lourdes R. Desviat -- RNA-Cleaving DNA Enzymes and Their Potential Therapeutic Applications as Antibacterial and Antiviral Agents / P. I. Pradeepkumar and Claudia Höbartner -- Hammerhead Ribozymes Against Virus and Viroid RNAs / Alberto Carbonell, Ricardo Flores and Selma Gago -- Suppression of Hepatitis C Viral Genome Replication with RNA-Cleaving Deoxyribozyme / Dal-Hee Min and Dong-Eun Kim -- Design of Synthetic shRNAs for Targeting Hepatitis C: A New Approach to Antiviral Therapeutics / Brian H. Johnston and Qing Ge -- The Diverse Active Sites in Splicing, Debranching, and MicroRNA Processing Around RNA Phosphodiester Bonds / Sourav Kumar Dey, Eduardo Paredes, Molly Evans and Subha R. Das -- MicroRNAs and Their Antagonists as Novel Therapeutics / Jeppe Vinther, Jakob Lewin Rukov and Noam Shomron -- microRNAs in Human Diseases and Viral Infections / Alessandra Mescalchin and Tobias Restle -- Dysregulation of MicroRNA Expression and Human Diseases? / To-Ha Thai -- Noncoding RNAs: Identification of Cancer-Associated MicroRNAs / Muller Fabbri and George A. Calin -- Targeting Non-coding RNAs for Cancer Therapy / Satya K. Kota and Savithri Balasubramanian -- MicroRNA Pathways in Drosophila / Geetanjali Chawla and Nicholas S. Sokol -- Viroids: The Smallest Known Infectious Agents Cause Accumulation of Viroid-Specific Small RNAs / Jaroslav Matoušek, Detlev Riesner and Gerhard Steger.
- 2009 SpringerDaniel John Rigden, editor.Section I: Generating and inferring structures. Ab Initio protein structure prediction / Jooyoung Lee, Sitao Wu, and Yang Zhang ; Fold recognition / Lawrence A. Kelley ; Comparative protein structure modelling / András Fiser ; Membrane protein structure prediction / Timothy Nugent and David T. Jones ; Bioinformatics approaches to the structure and function of intrinsically disordered proteins / Peter Tompa -- Section II: From structure to functions. Function diversity within folds and superfamilies / Benoit H. Dessailly and Christine A. Orengo ; Predicting protein function from surface properties / Nicholas J. Burgoyne and Richard M. Jackson ; 3D motifs / Elaine C. Meng, Benjamin J. Polacco, and Patricia C. Babbitt ; Protein dynamics: from structure to function / Marcus B. Kubitzki, Bert L. de Groot, and Daniel Seeliger ; Integrated servers for structure-informed function prediction / Roman A. Laskowski ; Case studies: Function predictions of structural genomics results / James D. Watson and Janet M. Thornton ; Prediction of protein function from theoretical models / Iwona A. Cymerman, Daniel J. Rigden, and Janusz M. Bujnicki.
- 2009 SpringerMichael Jay Katz.
- From signals to colours : a case-based atlas of electroanatomic mapping in complex atrial arrhythmias ; based on the experience of the Project of ElectroAnatomic mapping in Complex arrhythmia Evaluation (PEACE)2008 SpringerRoberto De Ponti.
- 2011Peiying Chuan.Myosins are a superfamily of molecular motors that couple the chemical energy derived form adenosine triphosphate (ATP) hydrolysis to precise mechanical movements along the filamentous cytoskeletal protein actin. There exist more than 20 distinct classes of myosins within this superfamily, and their specific biophysical and biochemical properties likely allow them to function accordingly in vivo. My research has focused on understanding the how the structural and kinetic characteristics of a particular myosin, myosin VI, relate to its proposed trafficking and tethering functions. In the first section of this dissertation, I perform single molecule studies on the contribution of an unexpected structural domain in the myosin VI tail to the efficiency of processive stepping, especially against external forces. I additionally use optical trapping to examine the load-dependent kinetics of the motor in the second section, and propose that external load in vivo likely regulates myosin VI's dual functions as cellular transporter and cytoskeletal anchor. The specific cellular cargoes as well as oligomerization states of different myosins are defined by their tail domain, which is the most divergent structural region among myosin classes. Myosin VI, shown to be monomeric when purified in its native form, likely dimerizes upon cargo binding. As most in vitro work on myosin VI so far have been performed on a truncated, artificially forced myosin VI dimer, I discuss in the third section steps taken toward achieving a more native, biochemically reconstituted full-length myosin VI molecule bound to its bona fide cargo. Having gained a better understanding of the biophysics, kinetics and biochemistry of myosin at the single molecule level, I moved on to studying myosin function at the cellular level. In the forth section of this dissertation, I examine the effects of a familial hypertrophic cardiomyopathy (FHC) mutation, R403Q in cardiac myosin, on the contractile function of single mouse cardiomyocytes. I find that the functional effects of the R403Q mutation in the diseased FHC heart are manifest at the level of cardiomyocytes as well, suggesting that these effects are cell autonomous. From these studies, we can better appreciate the structural and kinetic properties of myosin VI that make it uniquely suited for its functions. This knowledge is also beneficial in aiding the understanding of other molecular motors that may employ similar mechanisms. We are now also aware of the cell-autonomy of particular dysfunctions exhibited by diseased R403Q FHC hearts, and are better poised to understand the complex disorder as a whole.
- From solid state to soft matter : photonic nanocavities as advanced optoelectronic devices and single-cell biomedical probes2013Gary Shambat.Photonic nanocavities are wavelength-scale dielectric structures that possess remarkable properties due to their intrinsic small sizes and high quality factors. Simply by modifying the device materials and optical properties, one can realize nanocavities for diverse applications ranging from lasers to quantum optics and even biosensing. In this dissertation work, two drastically different functions of nanocavities are presented, both of which make them more practical for real-world adoption. The first part of this dissertation will focus on engineered optical devices for interconnect applications in computing and communications. We have shown that heavily doped germanium on silicon can be used as a CMOS-compatible light source with peak emission at 1.5 microns. Microdisk resonators were fabricated and shown to sustain cavity resonances through both photoluminescence (PL) and electroluminescence (EL) measurements. To access these microresonators, we developed a coupling process using a tapered optical fiber and further showed the versatility of these fibers by using them to tune the cavity wavelength. High performance optical sources were then demonstrated in a gallium arsenide platform containing embedded quantum dots (QDs). We have developed a new platform for efficiently driving photonic crystal (PC) cavities using a lithographically defined, lateral p-i-n junction. With our lateral junction we have demonstrated a world record low threshold laser with a threshold power of only 208 nW at 50K. At room temperature we find that these same devices behave as ultra-fast light-emitting diodes which can be directly modulated at up to 10 GHz with operational energies below 1 fJ/bit. Additional active photonic devices incorporating a lateral junction such as electro-optic modulators and photodetectors were also created using this same platform. The second part of this dissertation describes the demonstration of a whole new class of tools geared towards biomedical photonics that marry PC cavities to the tips of optical fibers. The form factor of the optical fiber lends itself to operation of the tool in exotic environments never before accessible to a nanocavity. Fiber-cavity hybrid devices were constructed using a custom epoxy-based assembly procedure which successfully relocates the small semiconductor templates containing nanocavities. The completed device, called a fiberPC, was then used as a sensor to detect gold nanoparticles through optical readout. We have used our probes to interrogate single human prostate cells with internalized PC cavities showing, for the first time, resonant photonic modes inside biological cells. The beams can be loaded in cells and tracked for days at a time, with cells undergoing regular division and migration. Furthermore, we present in vitro label-free protein sensing with our probes as a path towards quantitative, real-time biomarker detection in single cells. The developed tool may find future applications in drug screening, cancer detection, and fundamental cell biology.
- 2011Jamie Francine Conklin Imam.Embryonic stem cells (ESCs) hold great therapeutic potential, but the regulation of their self-renewal and pluripotency is still not fully understood. Furthermore, ESCs display many similarities to cancer cells, including rapid proliferation and tumorigenic potential, making it critical to understand the basic properties of these cells. The RB family, consisting of RB, p107, and p130, are critical regulators of functions such as cell cycle progression, apoptosis, and differentiation that must be tightly regulated throughout development. Here, we used loss and gain of function experiments to understand the role of the RB family in regulating key properties of ESCs. In hESCs, the RB family is critical for self-renewal and survival. hESCs overexpressing RB arrest in the cell cycle and undergo spontaneous differentiation and apoptosis. Loss of RB family function in hESCs results in decreased self-renewal ability and a loss of pluripotency, as these cells display a defect in their differentiation capacity. hESCs undergo a G2/M arrest and apoptosis through activation of the p53 pathway and the cell cycle inhibitor p21 upon loss of RB family function. In contrast to hESCs, mESCS triple knockout (TKO) for the RB family are largely normal. However, both mouse and human ESCs display genomic instability upon loss of RB family function, highlighting a key function that is conserved between both species. The RB family also regulates many functions that are critical for tumor suppression. We investigated whether RB retains its tumor suppressive ability in cancer cells by re-introducing RB into Rb-/-; p53-/- small cell lung cancer (SCLC) tumors cells. Re-introduction of RB resulted in decreased growth and an increase in differentiation, similar to that seen in hESCs. Thus, the RB pathway is an important regulator of self-renewal and differentiation in both hESCs and SCLC.
- 2014 SpringerLawrence B. Bone, Christiaan N. Mamczak, editors.This book is designed as an easy to read reference and practical guide to the management of combat extremity injuries, which account for a high percentage of the injuries sustained in recent and current conflicts. The surgical techniques appropriate to the full range of extremity injuries and some other frequent injuries, such as trauma to the spine and pelvis, are clearly described with the aid of helpful illustrations. In each chapter a bottom line up front approach is adopted, providing key messages first; a further important feature is the emphasis placed on case-based information and lessons learned from practice. Care has been taken to ensure that the advice provided is straightforward and in line with military clinical practice guidelines.
- 2011 SpringerMatthew Martin, Alec Beekley, editors.Prehospital and enroute care -- Combat triage and mass casualty management -- Initial management priorities: beyond ABCDE -- Damage control resuscitation -- To operate or image?: pulling the trigger -- Ultrasound in combat trauma -- The bowel: contamination, colostomies, and combat surgery -- Liver and spleen injury management in combat (old school) -- Pancreatic and duodenal injuries (sleep when you can ...) -- Operative management of renal injuries -- Major abdominal vascular trauma -- To close or not to close: managing the open abdomen -- Choice of thoracic incision -- Lung injuries in combat -- Diagnosis and management of penetrating cardiac injury -- Thoracic vascular injuries: operative management in "enemy territory" -- Chest wall and diaphragm injury -- Soft tissue wounds and fasciotomies -- Extremity injuries and open fractures -- Mangled extremities and amputations -- Peripheral vascular injuries -- The neck -- Geritourinary injuries (excluding kidney) -- Neurosurgery for dummies -- Spine injuries -- Face, eye, and ear injuries -- Burn care in the field hospital -- The pediatric patient in wartime -- The combat ICU team -- Postoperative resuscitation -- Monitoring -- Ventilator management: a practical approach to respiratory failure in combat casualties -- Practical approach to combat-related infections and antibiotics -- Stabilization and transfer from the far forward environment -- Humanitarian and local national care -- Expectant and end of life care in a combat zone.
- 2016 SpringerStilianos E. Kountakis, Brent A. Senior, Wolfgang Draf, editors.Addressing disease of the frontal sinus successfully remains, perhaps, one of the most technically challenging issues encountered by otolaryngologists. The intricate anatomy, combined with a narrow aperture and relatively acute angle of approach, leads to complexity not encountered elsewhere in surgery of the sinuses. This comprehensive volume with contributions by over 30 of the world's leading rhinologists will help to shed light on this difficult topic. Thorough discussions of anatomy and pathophysiology of a variety of frontal sinus diseases provide a background for in-depth chapters on as.
- 2006 Springer2006 MyiLibraryWan-Li Xing, Jing Cheng, editors.
- 2010 Springeredited by Rahul Jandial.In vivo imaging of cellular transplants / Justin Chan ... [et al.] -- Culture and manipulation of neural stem cells / Jennifer Katz, Bryan Keenan, and Evan Y. Snyder -- Animal models of neurological disease / Amol Shah ... [et al.] -- Stem cell transplantation methods / Kimberly D. Tran, Allen L. Ho and Rahul Jandial -- Stem cell origin of brain tumors / Dawn Waters, Ben Newman, and Michael L. Levy -- The tumor microenvironment / Lissa Baird and Alexey Terskikh -- Exploitation of genetically modified neural stem cells for neurological disease / Allen L. Ho, Sassan Keshavarzi, and Michael L. Levy -- Biological horizons for targeting brain malignancy / Samuel A. Hughes .. [et al.] -- Stem cells in the treatment of stroke / Klaudia Urbaniak Hunter, Chester Yarbrough, and Joseph Ciacci -- Gene- and cell-based approaches for neurodegenerative disease / Klaudia Urbaniak Hunter, Chester Yarbrough, and Joseph Ciacci.Also available: Print – 2010
- 2008 Kargervolume editors, Alessio Fasano, Riccardo Troncone, David Branski.Historical perspective of celiac disease / Guandalini, S. -- Natural history of celiac disease / Kaukinen, K.; Collin, P.; Mäki, M. -- The changing clinical presentation of celiac disease / Lebenthal, E.; Shteyer, E.; Branski, D. -- The global village of celiac disease / Catassi, C.; Yachha, S.K. -- HLA and non-HLA genes in celiac disease / Zhernakova, A.; Wijmenga, C. -- Twins and family contribution to genetics of celiac disease / Greco, L.; Stazi, M.A.; Clerget-Darpoux, F. -- Biochemistry and biological properties of gliadin peptides / Barone, M.V.; Auricchio, S. -- Innate immunity and celiac disease / Meresse, B. ... [et al.] -- Celiac disease: across the threshold of tolerance / Koning, F. -- The role of the intestinal barrier function in the pathogenesis of celiac disease / Fasano, A.; Schulzke, J.D. -- Diagnosis of coeliac disease: open questions / Auricchio, R.; Troncone, R. -- Current guidelines for the diagnosis and treatment of celiac disease / Caicedo, R.A.; Hill, I.D. -- Current therapy / Stern, M. -- Update on the management of refractory coeliac disease / Al-toma, A.; Verbeek, W.H.M.; Mulder, C.J.J. -- The National Institutes of Health consensus conference report / Cohen, M.B.; Barnard, J.A. -- Beyond coeliac disease toxicity: detoxified and non-toxic grains / Gilissen, L.J.W.J.; van der Meer, I.M.; Smulders, M.J.M. -- Oral glutenase therapy for celiac sprue / Ehren, J.; Khosla, C. -- Inhibitors of intestinal barrier dysfunction / Paterson, B.M.; Turner, J.R. -- Development of a vaccine for celiac disease / Anderson, R.P. -- Regulatory T cells in the coeliac intestinal mucosa: a new perspective for treatment? / Gianfrani, C. ... [et al.] -- Strategies for prevention of celiac disease / Hogen Esch, C.E. ... [et al.] -- Towards preventing celiac disease: an epidemiological approach / Ivarsson, A.; Myléus, A.; Wall, S. -- Animal models of celiac disease / Marietta, E.V.; Murray J.A.; David C.S.
- 2010 Kargervolume editors, Wolfgang Langhans, Nori Geary."The development of effective preventive and therapeutic measures to control eating and body weight involves basic physiology as well as cognitive and social psychology. The potential of molecular genetics to illuminate brain-behavior relationships became apparent with the discovery of the leptin gene in 1994. At present, molecular methodologies are being integrated with other physiological approaches, resulting in a number of options from which effective therapeutic strategies may evolve. This book highlights this exciting juncture: Fifteen leading experts present brief descriptions of some of the latest developments of the physiology of eating and weight regulation, ranging from endocrine and neural controls to genetics and functional brain imaging. These Frontier chapters are preceded by a general overview that provides requisite background on the physiology of eating as well as a conceptual framework for the Frontier chapters."--Publisher's description.
- 2015 SpringerBart C.J.M. Fauser, Andrea R. Genazzani, editors.This volume offers an up-to-date overview on the major areas of gynecological endocrinology, presenting the latest advances in adolescent gynecological endocrinology, assisted reproduction, menstrual-related disorders, sexuality and transsexualism, polycystic ovary syndrome, myometrial pathology and adenomyosis, obesity and metabolic syndrome, hormonal contraception, premature ovarian failure and menopause. In each chapter the recent advances deriving from basic science and clinical investigations are related to the practical management of the condition under consideration, taking into account the need for individualized therapies. The book is published within the ISGE Book Series, a joint venture between the International Society of Gynecological Endocrinology and Springer and is based on the 2014 International School of Gynecological and Reproductive Endocrinology Winter Course. It will be an important tool for obstetricians and gynecologists, endocrinologists and experts in women?s health as well as interested GPs.
- 2014 SpringerAndrea R. Genazzani, Mark Brincat, editors.This volume represents an up-to-date overview on the major areas of gynecological endocrinology, providing the reader with a complete explanation of female endocrine regulation and metabolism and relevant disorders and treatment. It is published within the International Society of Gynecological Endocrinology (ISGE) Series and is based on the 2013 International School of Gynecological and Reproductive Endocrinology Summer Course. The book covers a very wide range of topics from primary amenorrhea to menopause, from the impact of ovarian surgery on fertility to fertility cryopreservation, from metabolic syndrome and polycystic ovary to premature ovarian failure and from the clinical impact of selective progesterone receptor modulators to the use of progesterone in prevention of premature labor. It will be an important tool for obstetricians and gynecologists, endocrinologists and experts in women's health as well as interested GPs.
- Frontiers in gynecological endocrinology. Volume 3, Ovarian function and reproduction - from needs to possibilities2016 SpringerAndrea R. Genazzani, Basil C. Tarlatzis, editors.1. Luteal-phase stimulation -- 2. Management of luteal phase in IVF cycles -- 3. Genoics and ovarian response -- 4. Management of poor responders -- 5. Gene expression in cumulus cells and oocyte quality -- 6. Biomarkers of ovarian ageing -- 7. Premature ovarian insufficiency: advances in management through a global registry -- 8. The long-term risks of premature ovarian insufficiency -- 9. Pharmacological and integrative treatment of stress-induced hypothalamic amenorrhea -- 10. Adipose tissue and menstrual disturbances: obesity versus anorexia nervosa -- 11. Neuroendocrine basis of the hypothalamus-pituitary-ovary axis aging -- 12. Androgen replacement in women: safe and efficacious? -- 13. The ratio of MI to DCI and its impact in the tretment of polycystic ovary syndrome: experimental and literature evidences -- 14. Metabolic healthy obesity and metabolic obesity with normal weight and CVD risk in women -- 15. Myths of endometriosis: "endometriomas" -- 16. Vitamin D deficiency: diagnosis, prevention, and treatment - new consensus -- 17. Medical treatment of myomas -- 18. Contraception in climacterium -- 19. Management of symptoms during menopausal transition -- 20. The aging brain in women: impact of steroid replacement therapies -- 21. Current findings on soya and isoflavones -- 22. The importance of isoflavones for women's health -- 23. Gender-specific hypertension -- 24. Body identical hormone replacement: the way forward? -- Index.
- 2007 Springeredited by Po Sing Leung.
- 2009 SpringerNiranjan Bhattacharya, Phillip Stubblefield, editors.
- v. 9-, 1998- Karger
- v. 1-8, 1974-91. Karger
- 2014Bruce L. Miller, MD.History and nomenclature -- The clinical syndrome of bvFTD -- The clinical syndrome of svPPA -- The clinical syndrome of nfvPPA -- Related disorders : FTD-ALS -- Related disorders : corticobasal degeneration and progressive supranuclear palsy -- A primer of FTLD neuropathology -- FTD genes -- FTD reflections upon psychology and philosophy -- Treatments.
- v. 1-, 2009- SpringerCagle, Philip T.
- 2010 SpringerNicole C. Panarelli, Rhonda K. Yantiss.Intraoperative evaluation of colorectal specimens containing cancer -- Intraoperative evaluation for extracolonic disease in colon cancer patients -- Metastases and mimics of colorectal carcinoma -- Non-epithelial tumors of the colorectum -- Frozen section assessment of the colorectum in the pediatric population -- Frozen section evaluation of the appendix -- Frozen section evaluation of anal disease.
- 2011 SpringerOmar Hameed, Shi Wei, Gene P. Siegal.Introduction -- Bone/Osteoid Producing Lesions -- Cartilage-Producing Lesions -- Fibrous and Fibrohistiocytic Lesions -- Giant Cell-Rich Lesions -- Small/Round Cell Lesions -- Cystic and Vascular Lesions -- Epithelial Lesions.
- 2012 Springerby Syed K. Mohsin.1. Sentinel Lymph Nodes -- 2. Assessment of the Surgical Margins -- 3. Diagnostic Evaluation of a Breast Mass -- 4. Handling of Specimens with a Nonpalpable Lesion -- 5. Core Needle Biopsies -- 6. Regulatory Requirements for Breast Specimens.
- 2011 SpringerRichard A. Prayson, Karl M. Napekoski.Introduction -- Where to start -- Nonneoplastic flags -- Cerebral parenchymal lesions: I. Metastatic neoplasms -- Cerebral parenchymal lesions: II. Primary tumors -- Dural-based tumors -- Intraventricular lesions -- Cerebellar lesions -- Pituitary gland and sellar lesions -- Pineal gland lesions -- Spinal cord lesions.
- 2014 SpringerQihui "Jim" Zhai, editor.The Frozen Section Library series provides concise, user-friendly, site specific handbooks that are well illustrated and highlight the pitfalls, artifacts and differential diagnosis issues that arise in the hurried frozen section scenario. Written by expert surgical pathologists, Frozen Section Library: Endocrine Organs presents common and practical problems including follicular adenoma versus follicular carcinoma, papillary thyroid carcinoma versus reactive change and freezing artifact, follicular variant of papillary thyroid carcinoma, and medullary thyroid carcinoma. Anaplastic carcinoma, thyroid lymphoma, resection margin of a pancreatic endocrine tumor, pheochromocytoma within an adrenal gland and extra- adrenal gland, parathyroid tissue versus a thyroid tissue and versus a lymph node are also explored in detail. All chapters are illustrated with color pictures and accompanied legends. As a handbook for practicing pathologists, this volume is an indispensable aid to diagnosis and for avoiding dangers in one of the most challenging situations that pathologists encounter. Rapid consideration of differential diagnoses and how to avoid traps caused by frozen section artifacts are readily accessible. Tables and charts provide guidance for differential diagnosis of various histological patterns.
- 2009 Springer[edited by] Luan D. Truong, Steven S. Shen, Jae Y. Ro.
- 2011 SpringerQihui "Jim" Zhai, Ady Kendler.General considerations -- Nasal cavity and paranasal sinuses -- Salivary glands -- Oral cavity, pharynx, and larynx -- Neck -- Head and neck presentations of intracranial lesions.
- Fabry disease — Fire defense section bulletin (145)
- First aid cases for the USMLE step 2 CK. 2nd ed. — Foodborne diseases (145)
- Foodborne microbial pathogens : mechanisms and pathogenesis — Frozen section library. Head and neck (145)
- Frozen section library. Liver, extrahepatic biliary tree, and gallbladder — Fuzzy and rough techniques in medical diagnosis and medication (143)
- Harrison's Principles of Internal Medicine
- AAP Red Book Online
- Robbins & Cotran Pathologic Basis of Disease
- Sabiston Textbook of Surgery
- Nelson's Textbook of Pediatrics
- Surgical Exposures in Orthopaedics
- Mandell, Douglas, & Bennett's Principles & Practice of Infectious Diseases
- Red Book Online
- ICU Book
- Primary Care Medicine
- Campbell-Walsh Urology
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