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  • E. coli gene expression protocols 2002
    Springer Protocols
  • A textbook in the Illustrated Colour Text series on ENT, aimed at medical students and junior doctors. Concise presentation of ENT in the attractive ICT format - clear line diagrams, colour photos of clinical conditions, summary boxes etc. Covers a topic which is important in primary care - medical students and junior doctors are motivated to buy a book in this area. Basic anatomy and physiology is reviewed - useful revision for students in clinical years. Comprehensive coverage of both presenting symptoms and specific diseases, with more detail on the commoner conditions. Clear description of examination and investigation techniques.
  • Ear -- Nose, nasal sinuses, and face -- Mouth and pharynx -- Larynx and hypopharynx -- Voice, speech, and language -- Tracheobronchial tree -- Esophagus -- Neck (including the thyroid gland) -- Salivary glands.
  • Ear reconstruction 2013
    Ear reconstruction is required in a variety of patients, including especially those with congenital anomalies and associated deformities. In this book, a renowned practitioner in ear reconstruction explains the approaches that he has personally developed over the past 40 years in order to improve surgical results and also presents important new concepts. The proposed techniques offer tailored solutions to specific problems and are applicable in settings including severe microtia, moderate microtia, anotia, traumatic amputation, and unsatisfactory prominent ear surgery. Complications during and after ear reconstruction are also discussed, with guidance on their treatment. Throughout the book, the aim of the author is to share the fruits of his extensive experience with fellow surgeons in an informative and practically oriented way. The clearly written text is complemented by numerous helpful color photographs.
  • Ear surgery 2008
    Otosclerosis Surgery Complications, p. 1-12 -- Tympanoplasty/Ossiculoplasty, p. 13-27 -- Surgery for Chronic Otitis Media, p. 29-31 -- Complications of Chronic Otitis Media, p. 33-42 -- Petrous Apex Lesions, p. 43-53 -- Cholesteatoma, p. 55-60 -- External Auditory Canal Lesions, p. 61-65 -- Spontaneous Cerebral Spinal Fluid Otorrhea, p. 67-75 -- Facial Nerve Surgery, p. 77-88 -- Surgery for Vertigo, p. 89-98 -- Tumor Surgery, p. 99-110 -- Cochlear Implant Surgery, p. 111-115 -- Differential Diagnosis of Unilateral Serous Otitis Media, p. 117-120.
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  • The contemporary context of young adulthood. The contemporary context of young adulthood in the USA : from demography to development, from private troubles to public issues / Richard A. Settersten Jr. ; Transition to adulthood, parental support, and early adult well-being : recent findings from the youth development study / Jeylan T. Mortimer ; "First principles" : components, holism, and context of the transition to adulthood / Ross Macmillan ; Young adults in a wireless world / Eva S. Lefkowitz, Shelley N. Vukman, and Eric Loken -- Parent-child relationships and successful transitions. Relationships between young adults and their parents / Karen L. Fingerman ... [et al.] ; The implications of family context for the transition to adulthood / Monica Kirkpatrick Johnson and Janel Benson ; Child well-being and the long reach of family relationships / Kelly Musick and Ann Meier ; Young adults' "need" : in the eye of the beholder? / D. Wayne Osgood and Sonja E. Siennick -- Romantic and sexual relationships. Developmental shifts in the character of romantic and sexual relationships from adolescence to young adulthood / Peggy C. Giordano .. [et al.] ; Challenges in charting the course of romantic relationships in adolescence and emerging adulthood / Frank D. Fincham ; I just want your kiss? : sexual relationships in young adulthood / Kelly Raley -- Family contexts and timing of fertility. Becoming a parent : the social contexts of fertility during young adulthood / Kathryn Edin and Laura Tach ; Childbearing among cohabiting women : race, pregnancy, and union transitions / Daniel T. Lichter ; Understanding young fertility in the context of economic disadvantage / Marcia J. Carlson -- The study of young adulthood. New horizons in research on emerging and young adulthood / Jeffrey Jensen Arnett ; The role of family context in early adulthood : where we've been and where we're going / Jessica Halliday Hardie and Christine E. Stanik.
  • Also available: Print – 2011
    More than 40 articles provide an extensive coverage of advances over the last three years of research on subarachnoid hemorrhage-induced brain injuries and cerebral vasospasm. Early brain injury, the new frontier of subarachnoid hemorrhage research, which may be a key contributor to the high mortality and morbidity, promotes collaborative efforts from neurosurgery, neurology, neuro-ICU into other interrelated fields and basic neurosciences. For the first time, subarachnoid hemorrhage research is almost equally divided by early brain injury and cerebral vasospasm, mechanistic investigations and therapeutic approaches, demonstrating a translational feature of the future direction.
  • Print Material
    Contents. - pt. 1. Embryos of the first five weeks (to stage 15).
  • Early disease detection v. 1-2, 1970-71.
    Print Material
  • Clinically relevant study end points in rectal cancer -- Neoadjuvant treatment in rectal cancer : do we always need radiotherapy or can we risk assess locally advanced rectal cancer better? -- Treatment dilemmas in patients with synchronous colorectal liver metastases -- Pancreatic surgery : beyond the traditional limits -- Adjuvant therapy for pancreatic cancer -- Radiotherapy of the pancreas : state of the art in 2012 -- Adenocarcinoma of the GEJ : gastric or oesophageal cancer? -- Why is there a change in patterns of GE cancer? -- Endoscopic treatment for esophageal squamous cell carcinoma -- Open or minimally invasive resection for oesophageal cancer? -- Choosing the best treatment for esophageal cancer -- Multimodal therapy of GEJ cancer : when is the definitive radiochemotherapy the treatment of choice? -- Radiotherapy of gastroesophageal junction cancer -- Optimizing neoadjuvant chemotherapy through the use of early response evaluation by positron emission tomography -- Optimal surgery for gastric cancer : is more always better? -- Can adjuvant chemoratiotherapy replace extended lymph node dissection in gastric cancer? -- Predicting the response to chemotherapy in gastric adenocarcinoma : who benefits from neoadjuvant chemotherapy? -- Prediction of response and prognosis by a score including only pretherapeutic parameters in 410 neoadjuvant treated gastric cancer patients -- Adjuvant chemotherapy : an option for Asian patients only? -- Selecting the best treatment for an individual patient.
  • "This Recent Results in Cancer Research volume provides an up-to-date overview of the multidisciplinary management of locally confined rectal cancer as well as colorectal cancer with synchronous resectable liver metastases. The contents comprise the majority of the invited contributions from the Second St. Gallen EORTC Gastrointestinal Cancer Conference, held on 6-8 March 2014 in St. Gallen, Switzerland. Written by some of the world's leading experts in the imaging, endoscopy, pathology, molecular biology, surgery, radiotherapy, and medical oncology of rectal cancer and liver metastases, the chapters offer a comprehensive view on the latest recommendations in diagnosis and multidisciplinary treatment. Every clinician involved in the care of patients with rectal cancer will find this book interesting and helpful."--Publisher's description.
  • Also available: Print – 2001
  • Also available: Print – 2006
    1. The Developmental origins of health and disease: the breadth and importance of the concept / Peter D. Gluckman and Mark A. Hanson -- 2. Developmental origins of cardiovascular disease, type 2 diabetes, and obesity in humans / Caroline H.D. Fall -- 3. Studies of twins: what can they tell us about the developmental origins of adult health and disease? / Ruth Morley, Terence Dwyer, and John B. Carlin -- 4. Prenatal programming of human motor function / Julia B. Pitcher, David J. Henderson-Smart, and Jeffrey S. Robinson -- 5. Adaptive responses of early embryos to their microenvironment and consequences for post-implantation development / Jeremy Thompson, Michelle Lane, and Sarah Robertson -- 6. Modification of epigenetic state through dietary manipulation in the developing mammalian embryo / Nicola Vickaryous and Emma Whitelaw -- 7. Critical experiments to determine if early nutritional influences on epigenetic mechanisms cause metabolic imprinting in humans / Robert A. Waterland -- 8. Manipulation of the maternal diet in rat pregnancy: different approaches to the demonstration of the programming principle / Simon C. Langley-Evans [et al.] -- 9. Programming hypertension-animal models: causes and mechanisms / Kate M. Denton, Michelle M. Kett, and Miodrag Dodic -- 10. Developmental programming of cardiovascular dysfunction / Lucilla Poston, James A. Armitage, and Paul D. Taylor -- 11. Kidney development and fetal programming / Karen M. Moritz and Luise A. Cullen-McEwen -- 12. Programming of obesity-experimental evidence / Bernhard H. Breier, Stefan O. Krechowec, and Mark H. Vickers -- 13. Perinatal programming of adult metabolic homeostasis: lessons from experimental studies / Kathryn l. Gatford ... [et al.] -- 14. Programming effects of excess glucocorticoid exposure in late gestation / Timothy J.M. Moss and Deborah M. Sloboda -- 15. Programming effects of moderate and binge alcohol consumption / Jeff Schwartz and Luke C. Carey -- 16. Vitamin D in pregnancy and offspring health / Marianne Tare, Helena C. Parkington, and Ruth Morley -- 17. The Fetal origins of adult mental illness / Laura Bennet and Alistair J. Gunn -- 18. Hypoxia, fetal growth and developmental origins of health and disease / Dino A. Giussani.
  • Foreword / J.H. Schwartz, I. Tattersall -- Szombathy's excavations in the Mladeč Cave and the first presentations of the results / W. Antl-Weiser -- In search of prototypes - historical soft-tissue reconstructions of Mladeč 1 / M. Teschler-Nicola -- The structure of the cave, stratigraphy, and depositional context / J.A. Svoboda -- The Upper Paleolithic finds from the Mladeč Cave / M. Oliva -- Taphonomic aspects of the human remains from the Mladeč Caves / M. Teschler-Nicola -- Large mammal remains from the Mladeč Caves and their contribution to site formation processes / M. Pacher -- ¹⁴C dating of early Upper Palaeolithic human and faunal remains from Mladeč / E.M. Wild ... [et al.] -- Inventory and photo-documentation of the Mladeč hominid remains / M.H. Wolpoff ... [et al.] -- Aurignacian male crania, jaws and teeth from the Mladeč Caves, Moravia, Czech Republic / D.W. Frayer ... [et al.] -- Aurignacian female crania and teeth from the Mladeč Caves, Moravia, Czech Republic / M.H. Wolpoff, D.W. Frayer and J. Jelínek -- Electronic segmentation methods reveal the preservation status and otherwise unobservable features of the Mladeč 1 cranium / H. Prossinger and M. Teschler-Nicola -- The Mladeč 3 infant / N. Minugh-Purvis, Th. Bence Viola and M. Teschler-Nicola -- The human postcranial remains from Mladeč / E. Trinkaus ... [et al.] -- Lost, destroyed or misidentified postcranial specimens from Mladeč / M.H. Wolpoff, D.W. Frayer and J. Jelínek -- External geometry of Mladeč neurocrania compared with anatomically modern humans and Neanderthals / G.W. Weber ... [et al.] -- Pathological alterations and traumas in the human skeletal remains from Mladeč / M. Teschler-Nicola ... [et al.] -- No evidence of Neandertal mtDNA contribution to early modern humans / D. Serre ... [et al.] -- Non-destructive determination of ⁸⁷Sr/⁸⁶Sr isotope ratios in early Upper Paleolithic human teeth from the Mladeč Caves - preliminary results / T. Prohaska ... [et al.].
  • Endoscopic Screening and Surveillance-Indications and Standards -- Histopathology of Early Mucosal Neoplasias-Morphologic Carcinogenesis in the GI Tract -- Principles of Endoscopic Resection-Diagnostic and Curative Resection of Mucosal Neoplasias -- Endoscopic Detection and Analysis of Mucosal Neoplastic Lesions -- Enhanced Imaging and Tumor Morphology -- High-resolution Endoscopic Ultrasound -Clinical T-staging of Mucosal Neoplasms -- Squamous Cell-lined Esophagus and Hypopharynx -- Mucosal Neoplasias -- Columnar Epithelium-lined (Barrettś) Esophagus -- Mucosal Neoplasias -- Stomach-Mucosal Neoplasias -- Duodenum and Small Bowel -- Mucosal Neoplasias -- Colorectum-Mucosal Neoplasias -- Chronic Inflammatory Bowel Disease in Remission -Mucosal Neoplasias.
  • Animal studies of the effects of early nutrition on long-term health / Harding, J.E. ... [et al.] -- Dietary lipid quality and long-term outcome / Novak, E.M., Keller, B.O. and Innis, S.M. -- How proteins improve the development of preterm infants / Corpeleijn, W.E. ... [et al.] -- The knowns and unknowns of human milk banking / Simmer, K. -- Short- and long-term effects of probiotics administered early in life / Szajewska, H. -- New findings from the feeding infants and toddlers study 2008 / Siega-Riz, A.M. ... [et al.] -- Weaning practices in other parts of the world : case study India / Agarwal, K.N. -- Weaning practices in other parts of the world : case study Russia / Baturin, A.K. -- Micronutrient deficiencies and effect of supplements on correcting them / Zlotkin, S. -- Food allergy and complementary feeding / Shreffler, W.G. and Radano, M. -- Early feeding : setting the stage for healthy eating habits / Mennella, J.A. and Ventura, A.K. -- Early feeding practices and development of food allergies / Lack, G. and Penagos, M. -- Learning to prefer the familiar in obesogenic environments / Birch, L.L. and Anzman-Frasca, S. -- Early feeding practices and their impact on development of celiac disease / Fasano, A. and Catassi, C. -- Infant feeding practices and subsequent development of adipose tissue / Stettler, N. -- Early life nutrition and bone development in children / Jones, G. -- IGF-I signaling and effects on longevity / Holzenberger, M.
  • Also available: Print – 2005
    What is the EU infant nutrition cluster? -- Early nutrition and its later consequences: new opportunities -- The developmental origins of adult health and well-being -- Long term effects of breastfeeding on the infant and mother -- Experimental evidence for long-term programming effects of early diet -- Candidate genes for obesity--how might they interact with environment and diet? -- Rate of growth in early life: a predictor of later health? -- Protective effect of breast-feeding against obesity in childhood-- Discussion forum: from innovation to implementation -- Challenges and opportunities in pan-European collaboration for researchers from Central and Eastern Europe -- Best practice in communicating the results of European research to the public -- Longterm effects of pre- and postnatal exposure to low and high dietary protein levels / Cornelia C. Metges -- Protein intake in the first year of life: a risk factor for later obesity? -- The role of long-chain poly-unsaturated fatty acids (LCPUFA) in growth and development -- Experimental models for studying perinatal lipid metabolism -- Effect of N-3 polyunsaturated fatty acid supplementation in pregnancy: the Nuheal trial -- Young researchers' workshop -- Consumer needs regarding dietetic products for pregnant and lactating women and for baby foods -- Focus group: breakfast meeting: SMES and their co-operation with academia -- Ethical issues in perinatal nutrition research -- Early programming of diabetes risk--an introduction -- Early nutrition and later diabetes risk -- Is type 1 diabetes a disease of the gut immune system triggered by cow's milk insulin? -- Gluten-free diet in subjects at risk for type 1 diabetes: a tool for delaying progression to clinical disease? -- Insulin like growth factor regulation of body mass in breastfed and milk formula fed infants -- Inverse association between trans isomeric and long-chain polyunsaturated fatty acids in erythrocyte membrane lipids in pregnant women -- Comparison of essential fatty acid status among German, Hungarian and Spanish women at mid-gestation -- Trans isomeric fatty acids as confounding variables in studies on perinatal LC-PUFA supply -- An eight years prospective study of iron deficiency anaemia in infancy -- New insights in the potential mechanism of action of nucleotides to modulate immunity -- Thriving of malnourished breastfed infants after additional formula milk feeding -- Role of mammary gland lipoprotein lipase in the availablilty of polyunsaturated fatty acids for milk synthesis -- Is the crying behaviour in infants up to the age of 3 months influenced by the type of early nutrition? -- Dietary gangliosides: beneficial effects for the neonate and potential mechanism of action -- Leptin in breast-fed and formula-fed infants -- Dietary fatty acids during pregnancy determines maternal fatty acid profile during late pregnancy and their availability to the fetus even during fasting condtions -- Effects of oil-supplemented diets on liver expression of PPAR alpha-related genes in pregnant rats -- Effect of a new infant formula enriched with prebiotics, probiotics, nucleotides and LC-PuFA on recovery after infection -- Does habitual protein intake in early childhood influence age and body mass index at adiposity rebound? -- Dietary compliance in diabetes prevention project in Finland -- Changes of plasma fatty acid profile and antioxidant vitamins during normal pregnancy -- Optimal design for the recruitment of participants as a factor for the effective implementation of a clinical trial -- The effect of ponderal index on plasma concentration of insulin-like growth factor-1 (IGF-1) in neonatal pigs -- Effects of prenatal exposure to low and high dietary protein levels on maternal and fetal amino acid metabolism in rats -- Cow's milk introduction in Spanish infants -- Longer term effects of early cholesterol intake on cholesterol biosynthesis and plasma lipids: a randomized clinical trial -- Patterns of growth and energy utilization of the diet after a period of dietary restriction during the weaning period -- Infant formula feeding pattern and weaning introduction in Spanish infants -- Visual evoked potentials in infants after dietary supply of docosahexaenoic acid and 5-methyltetrahydrofolate during pregnancy -- Electronic data capture and use of internet technologies in a double-blind randomised intervention trial -- Breastfeeding and baby friendly hospital initiative in Slovenia -- Nutritional status in young adults with screen-detected silent/sub-clinical coeliac disease -- Liporotein lipase (LPL) MRNA expression in placentas from normal and IUGR (intrauterine growth restricted) pregnancies by real-time PCR -- Maternal fasting effect on neonatal health -- The quality of schoolchildren's nutrition in Serbia -- Tendency towards obesity in Sydney school children -- Monitoring and supervising a dietary intervention trial using modern data processing system -- Analysis of drop-outs in a longitudinal study -- Recruitment strategies of the Spanish group in the "EU childhood obesity: programming by infant nutrition" -- Diet and nutritional risk factors in schoolchildren -- Influence of two forms of caseinophosphopeptide on iron bio availability -- Model of childhood obesity primary prevention programme -- Problems related to recruitment of participants for the triger project -- Vitamin D status at birth in Brussels--preliminary results -- Obesity among young adolescent Kuwaitis -- Dynamic changes in adiposity from fetal to postnatal life are involved in the adult metabolic syndrome associated with reduced fetal growth -- Excess fetal adiposity is associated with programming of placental lipid genes -- Appetite control in breastfed and formula fed infants -- What are the Danone Institutes.
  • Also available: Print – 2009
  • Early writings v. 1-, 1975-
    Print Material
    v. 2. Genitality in the theory and therapy of neurosis.
  • User-friendly and well organized, Easy EMG is designed to help residents learn the fundamental principles of electrodiagnostic testing (including nerve conduction studies and needle EMG). This one-of-a-kind resource offers expert guidance on performing and interpreting EMGs, as well as how to test the most common conditions encountered in daily practice. At-a-glance tables combine with clear illustrations and a pocket-sized format to make Easy EMG ideal for on-the-go reference!
  • Easy injections 2007
    Introduction to injections -- Medications and injection supplies -- Joints -- Tendons -- Bursae -- Nerves -- Trigger point injections -- Botulinum toxin -- Prolotherapy -- Acupuncture -- Sympathetic injections -- Spinal injections.
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    Perspectives -- Introduction -- 1. Classification -- 2. Epidemiology -- 3. Etiology and pathogenesis -- 4. Diagnosis -- 5. General management principles -- 6. Treatment of anorexia -- 7. Treatment of bulimia -- 8. Course and prognosis -- 9. Other eating disorders -- 10. Research areas -- 11. Case studies -- Useful resources -- Index.
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  • Eating disorders, addictions, and substance use disorders are each challenging in their own right, but they also commonly co-occur, causing major challenges for clinicians. Emerging research suggests that there are common substrates at the neuroanatomical, neurochemical, and psychological levels. While randomized controlled trials have revealed a number of effective psychotherapeutic and psychopharmacologic treatments for the individual conditions, little is known about integrative interventions for these comorbidities. This book presents cutting-edge research on the overlap of these complex disorders and reviews integrative assessment strategies and treatment approaches, including enhanced cognitive behavioral therapy, dialectical behavior therapy, abstinence approaches, motivational enhancement, mindfulness meditation, and pharmacotherapy. The issue of whether eating-disordered behaviors such as dieting, binge eating, and excessive exercise are merely other forms of addictive behavior is examined. The authors argue both for and against the concept of food addiction in research, clinical treatment, and public policy.
  • At least 40 skin signs are associated with eating disorders (EDs), and some of them are considered guiding signs because they are indicative of an otherwise hidden ED. These skin signs may arise due to starvation, self-induced vomiting, drug consumption, and concomitant psychiatric illness. The role of the dermatologist in this context is to suspect the presence of a hidden ED based on the guiding signs. With this in mind, the most important specialists in the field come together in this book to document all of the dermatological aspects of EDs. General topics such as classification of EDs, epidemiology, and medical complications are first addressed, and skin signs attributable to various causes are then discussed in a series of detailed chapters. Characteristic changes in the hair, nails, and oral cavity are also carefully documented. The closing chapters address various other related issues of interest, including pain sensitivity in patients with EDs and the effects of anorexia nervosa on skin thickness and skin collagen. Eating Disorders and the Skin will be an invaluable source of up-to-date information for both novice and experienced dermatologists, as well as other practitioners with an interest in EDs, psychiatrists, and nurses.
  • "Foreword When I was a young woman being treated for an eating disorder, certain assumptions were made: if you had an eating disorder, you would be a white adolescent girl from a family with a controlling mother and an absent father. You would display a passive personality and low self-esteem. You would in all likelihood have signs of depression; whether you did or not, you would probably be treated for it. Your treatment team would see and treat you as childish and immature, and hold a variety of vague and often unfounded opinions about who you were, where you'd been, and what kind of chances of recovery you had. Those chances were considered, almost across the board, very low indeed. I was treated for eating disorders in the 1980s and 1990s. The medical and therapeutic understanding of the etiology, nature, and treatment of disordered eating and body image had not changed markedly since the early days of eating disorder research 20 years before. Likewise, the limited understanding of the demographics of eating disordered populations ensured that thousands would go undiagnosed and untreated. While the eating disordered population exploded, research and treatment providers held fast to their notions of what they were dealing with and how they should proceed. Their abysmal success rates bewildered them; they attributed these low rates of recovery to the intractable, probably incurable nature of the diseases. This second edition of Eating Disorders in Women and Children: Prevention, Stress Management, and Treatment is being released into a therapeutic community that has changed in many critical ways, and I believe the community will see further change as a result of the research done here"--Provided by publisher.
  • A synthesis of the best available evidence on diagnosis, management and treatment of frequent and high-cost problems occurring in primary care, inpatient and emergency department settings. Includes the top conditions; recommends a course of action for diagnosis, disease management and drug therapy.
  • Introduction -- Roles of EBNA1 at EBV Episomes -- EBNA1-DNA Interactions -- EBNA1 Contributions to EBV-Associated Tumours -- Cellular Effects of EBNA1 -- Conclusion.
  • The Overview of Needs and Requirements covers the costs of the Ebola response and preparedness activities. The needs and requirements are based on the latest information available from each of the most affected countries. The national plans and budgets comprise the framework and the Overview of Needs and Requirements defines the contributions planed by the UN system as well as the major international civil society organizations.
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    The ECG in healthy people -- The ECG in patients with palpitations and syncope -- The ECG in patients with chest pain -- The ECG in patients with breathlessness -- The effect of other conditions on the ECG -- The ECG in pacemakers, defibrillators and electrophysiology/ David Adlam -- Conclusions : four steps to making the most of the ECG
  • Section 1: The ECG in Prehospital Patient Care. Clinical Applications of the Electrocardiogram (ECG) / Robert C Schutt, William J Brady, Steven H Mitchell -- Clinical Impact of the Electrocardiogram (ECG) / Robert C Schutt, William J Brady, Steven H Mitchell -- Interpretation of the Electrocardiogram : Single-, Multi-, and 12-Lead Analysis / Robert C Reiser, Robert C Schutt, William J Brady -- Variants of the Normal, Lead Misplacement, and Electrocardiographic Artifact Encountered in Clinical Practice / Robert C Reiser, Robert C Schutt, William J Brady -- Section 2: Cardiac Rhythms and Cardiac Dysrhythmias. Cardiac Rhythms with Normal Rates / Korin B Hudson, William J Brady -- Narrow QRS Complex Tachycardia / Courtney B Saunders, Jeffrey D Ferguson -- Wide QRS Complex Tachycardia / Michael Levy, Francis X Nolan -- Bradycardia / Korin B Hudson, J Aidan Boswick, William J Brady -- Atrioventricular Conduction Block / Steven H Mitchell, Korin B Hudson, William J Brady -- Intraventricular Conduction Block: Bundle Branch Block and Other Conduction Abnormalities / Steven H Mitchell, Richard B Utarnachitt, William J Brady -- Atrial and Ventricular Ectopic Beats / Jeffrey D Ferguson, Michael Levy, J Aidan Boswick, William J Brady -- Section 3: Acute Coronary Syndrome and the 12-Lead ECG. Ischemic Heart Disease: Anatomic and Physiologic Considerations / Peter Pollak, Peter Monteleone, Kelly Williamson, David Carlberg, William J Brady -- Historical Development of the Prehospital Electrocardiogram (ECG) / Erik Iszkula, David Carlberg, William J Brady -- Electrocardiographic Findings in Acute Coronary Syndrome / Peter Monteleone, Peter Pollak, David Carlberg, William J Brady -- Section 4: Special Populations, High-Risk Presentation Scenarios, and Advanced Electrocardiographic Techniques. The Electrocardiogram in the Pediatric Patient / Robert Rutherford, Robin Naples, William J Brady -- The Electrocardiogram in the Poisoned Patient / Steven H Mitchell, Christopher P Holstege, William J Brady -- The Electrocardiogram in Hyperkalemia / Steven H Mitchell, William J Brady -- Life-Threatening Electrocardiographic Patterns / Steven H Mitchell, Richard B Utarnachitt, William J Brady -- The Electrocardiogram in Patients with Implanted Devices / Amita Sudhir, William J Brady -- Electrocardiographic Tools in Prehospital Care / Robin Naples, Alvin Wang, William J Brady -- Wolff-Parkinson-White Syndrome / William J Brady -- Cardiac Arrest Rhythms / Amita Sudhir, William J Brady -- Section 5: Electrocardiographic Differential Diagnosis of Common ECG Presentations. Electrocardiographic Differential Diagnosis of Narrow Complex Tachycardia / Megan Starling, William J Brady -- Electrocardiographic Differential Diagnosis of Wide Complex Tachycardia / Amita Sudhir, William J Brady -- Electrocardiographic Differential Diagnosis of Bradyarrhythmia / Megan Starling, William J Brady -- Electrocardiographic Differential Diagnosis of ST Segment Elevation / Megan Starling, William J Brady -- Electrocardiographic Differential Diagnosis of ST Segment Depression / Amita Sudhir, William J Brady -- Electrocardiographic Differential Diagnosis of T Wave Abnormalities: The Prominent T Wave and T Wave Inversions / Amita Sudhir, William J Brady.
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    What the ECG is about -- Conduction and its problems -- The rhythm of the heart -- Abnormalities of P waves, QRS complexes and T waves -- How to use the ECG -- Reminders -- Now test yourself.
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    Anatomy and physiology of the heart -- Electrophysiology -- Waveforms, intervals, segments, and complexes -- Cardiac monitors -- Analyzing a rhythm strip -- Sinus arrhythmias -- Atrial arrhythmias -- AV junctional arrhythmias and AV blocks -- Ventricular arrhythmias and bundle-branch block -- Pacemakers -- Posttest.
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  • Echinodermata 2005
    Are echinoderms of interest to biotechnology? / C. Petzelt -- Cell adhesion and communication : a lesson from echinoderm embryos for the exploitation of new therapeutic tools / F. Zito ... [et al.] -- Cell signalling during sea urchin development : a model for assessing toxicity of environmnetal contaminants / C. Angelini ... [et al.] -- Echinoderm reactive oxygen species (ROS) production measured by peroxidase, luminol-enhanced chemiluminescence (PLCL) as an immunotoxicological tool / G. Coteur, B. Danis, P. Dubois -- Monitoring chemical and physical stress using sea urchin immune cells / V. Matranga ... [et al.] -- DNA damage and developmental defects after exposure to UV and heavy metals in sea urchin cells and embryos compared to other invertebrates / H.C. Schröder ... [et al.] -- Echinoderms : their culture and bioactive compounds / M.S. Kelly -- Regenerative response and endocrine disrupters in crinoid echinoderms : an old experimental model, a new ecotoxicological test / M.D. Candia Carnevali -- Echinoderm adhesive secretions : from experimental characterization to biotechnological applications / P. Flammang, R. Santos, D. Haesaerts -- Mutable collagenous tissue : overview and biotechnological perspective / I.C. Wilkie -- Bioresources from echinoderms / Y. Yokota.
  • Also available: Print – 2006
    How to obtain a good echocardiography examination: ultrasound physics, technique, and medical knowledge -- Transthoracic echocardiography: M-mode, two-dimensional, and three-dimensional -- Transesophageal and intracardiac echocardiography / Jae K. Oh ... [et al.] -- Doppler echocardiography and color flow imaging: comprehensive noninvasive hemodynamic assessment -- Tissue doppler imaging, strain imaging, and dyssynchrony assessment / Brian D. Powell ... [et al.] -- Contrast echocardiography -- Assessment of systolic function and quantification of cardiac chambers -- Assessment of diastolic function and diastolic heart failure -- Pulmonary hypertension and pulmonary vein stenosis -- Coronary artery disease and acute myocardial infarction -- Stress echocardiography -- Valvular heart disease -- Prosthetic valve evaluation -- Infective endocarditis -- Cardiomyopathies -- Cardiac diseases due to systemic illness, genetics, medication, or infection -- Pericardial diseases -- Tumors and masses -- Diseases of the aorta -- Echocardiography in congenital heart disease: an overview / Frank Cetta, Jr., James B. Seward, Patrick W. O'Leary -- Intraoperative echocardiography / Roger L. Click, Jae K. Oh -- Vascular imaging and tonometry / A. Rauoof Malik, Iftikhar J. Kullo -- Goal-directed and comprehensive examination.
  • This atlas of echocardiography presents more than 100 cases of adult congenital heart disease, from diagnosis to treatment follow-up. The coverage is broad, encompassing atrial and ventricular septal defects, patent ductus arteriosus, cyanotic adult congenital heart disease, and numerous other anomalies, as well as findings on fetal echocardiography. For each disease, all echocardiographic images and views which proved of diagnostic value are arranged sequentially, with inclusion of transesophageal echocardiographic images whenever appropriate. Additional pertinent information is provided relating to diagnosis and treatment, and key teaching points are highlighted. The superb quality of the illustrations and the range of cases considered (including many rare ones) ensure that this atlas will be of great value for cardiology residents and fellows and highly relevant to day-to-day practice.
  • Echocardiography has become an invaluable tool in intensive care medicine because of its ease of use and instantaneous provision of precise information on cardiovascular functional anatomy at the bedside. This book contains all the information that readers will require in order to perform echocardiography and lung ultrasound, and to interpret the findings correctly, permitting optimal guidance of the hemodynamic management of unstable patients. Furthermore, lung ultrasound is dealt with for both diagnosis and treatment of respiratory failure requiring mechanical ventilation. After an introductory chapter on the essential physics of ultrasonography, standard echocardiographic examination via both the transthoracic and the transesophageal approach is described. In the third section, the functional anatomy of all normal and pathologic thoracic structures as observed on echocardiography is presented in detail. A wide range of basic and advanced applications of echocardiography in the emergency and intensive care setting are then described. A final supplementary section considers further applications of ultrasound in the intensive care unit, such as ultrasound-guided vein cannulation, Doppler renal evaluation, transcranial Doppler, and lung and pleural ultrasound. This superbly illustrated book has been specifically designed to meet the needs of all intensivists, emergency physicians, and anesthesiologists who intend to use ultrasound extensively to guide optimal management of the critically ill.
  • A volume in the exciting new Practical Echocardiography Series edited by Dr. Catherine M. Otto - provides practical how-to-do-it guidance on echocardiography for an ever-growing number of pediatric and adult congenital heart disease patients. Drs. Mark B. Lewin and Karen Stout offer you definitive, expert instruction with a highly visual, case-based approach that facilitates understanding and equips you to accurately acquire and interpret images while avoiding pitfalls. Master challenging and advanced techniques including 3-D echocardiography and transesophageal echocardiography through a practical, step-by-step format that provides a practical approach to data acquisition and analysis, technical details, pitfalls, and case examples. Expand your knowledge and apply the latest findings on congenital cardiovascular abnormalities and adult congenital heart disease. Reference the information you need quickly thanks to easy-to-follow, templated chapters, with an abundance of figures and tables that facilitate visual learning. Master echocardiography techniques for pediatric and adult patients with Congenital Heart Disease.
  • Distinguishing systolic vs. diastolic heart failure : a practical approach by echocardiography / Tasneem Z. Naqvi -- Evaluation of the patient with systolic heart failure / Maurice Enriquez Sarano and Sorin Pislaru -- Echo parameters important for clinical decision making in HF / Bob McNamara -- Evaluation of the patient with diastolic dysfunction / Ted Abraham, Jacob Abraham, and Kristian Eskesen -- Hypertensive heart failure / Richard Devereux and Fay Lin -- Heart failure due to coronary disease / Martin St. John Sutton, Yan Wang, and Ted Plappert -- Hypertrophic cardiomyopathy / Anna Woo and Sean Jedrzkiewicz -- Role of echocardiography in patients treated with cardiotoxic drugs / Bonnie Ky -- Assessment of treatment for systolic CHF / Judy Hung -- Echocardiography in the patient with right heart failure / Susan Wiegers and Anjali Tiku Owens -- Heart failure due to congenital heart disease / Meryl Cohen -- Echocardiographic evaluation of ventricular support devices / James Kirkpatrick -- The role of echocardiography for OHT / Amresh Raina.
  • This book provides a comprehensive account of the role of echocardiography in patients with mitral valve disease. The normal echocardiographic anatomy of the mitral valve is first presented, and the applications of echocardiography in mitral valve disease are then covered in detail by experts from different subspecialties in cardiology. Topics include etiology, pathophysiology, diagnosis, assessment of severity, and role of echocardiography in percutaneous and surgical techniques. The highly readable text is supported by a wealth of color images obtained with 3D echocardiography, currently the gold standard for the evaluation of mitral valve disease. The interdisciplinary approach used in describing the diagnostic and therapeutic applications will make this book useful for the clinical cardiologist as well as the echocardiographer. It will allow cardiologists to advance their knowledge in the field and will serve as an excellent updating tool for professionals engaged in echocardiography and cardiac diagnostic imaging.
  • Ultrasounds, a much reflected system -- The doctor in front of the machine -- The doctor and the machine in front of the patient -- The doctor, the machine, and the patient in front of the screen -- Learning methods -- Self-training procedure.
  • Also available: Print – 1885.
  • Extracorporeal membrane oxygenation (ECMO) has been in clinical use for some 40 years, but it is only in the past decade that its application in the treatment of life-threatening circulatory and respiratory failure has truly flourished. This book presents a comprehensive overview of both pathophysiological and practical aspects of circulatory and respiratory extracorporeal support. The basics of ECMO, including its history, the "ECMO team", cannulation, materials, and blood-surface interactions, are first discussed. The various indications for and particular characteristics of circulatory and respiratory extracorporeal life support are then described in detail in the main part of the book. Patient care during ECMO and monitoring of the ECMO patient are also carefully covered, with explanation of the management of technical and clinical complications and transport-related problems. Further topics include long-term therapy options beyond ECMO, such as ventricular assist devices and transplants, outcome, the new frontiers of ECMO for organ procurement and future challenges. The authors are well-known experts in the field whose authoritative contributions and attention to practical aspects will be invaluable for novices and experienced practitioners alike.
  • Understanding the causes and consequences of biological diversity remains the unifying goal of ecology and evolutionary. One promising avenue to understand the causes and consequences of genetic diversity within populations is to consider correlations between that genetic diversity and species diversity of the community in which it resides. Both genetic and species diversity can respond to locality characteristics, or each level can influence and be influenced by the other. First, I investigate how area connectivity and gene flow affects the population genetic diversity patterns in the California vole (Microtus californicus). I show that migration across the landscape produces an identical genetic patterns at the local and regional spatial scales in this small mammal (Chapter 1). Next, I explored two ways in which genetic and species diversity influence each other. In one approach, I examine the effects of a species-rich competitor community on the genotypic diversity of a focal community when genetic diversity allows for differential strength of competition with different species. Using computer simulations, I show that species diversity of competitors can act as an important promoter of genotypic diversity within species (Chapter 2). Next, moving to a riparian community in northern Utah, I demonstrate that the genetic diversity of a foundation tree correlates positively with the species diversity of understory plants, including forbs, grasses, and vines (Chapter 3). Finally, I show that both genetic diversity and species richness across the globe show a similar pattern: genetic markers in over 70 vertebrate species show a significant trend of higher diversity at low latitudes than at higher latitudes (Chapter 4). By taking a broad approach to understanding the causes and consequences of intraspecific genetic diversity, with a particular focus on links to species diversity patterns, my dissertation finds general principles that operate across systems. The two levels of diversity can influence each other by creating spatially-varied selection regimes, but gene flow and mutation are two processes operating on the genetic level whose power to scale up to influence species-level patterns is highly contextual.
  • Also available: Print – 2014
    "Researchers in the field of ecological genomics aim to determine how a genome or a population of genomes interacts with its environment across ecological and evolutionary timescales. Ecological genomics is trans-disciplinary by nature. Ecologists have turned to genomics to be able to elucidate the mechanistic bases of the biodiversity their research tries to understand. Genomicists have turned to ecology in order to better explain the functional cellular and molecular variation they observed in their model organisms. Ecological genomics covers 3 fields of research that have most benefited from the recent technological and conceptual developments in the field of ecological genomics: the study of life-history evolution and its impact of genome architectures; the study of the genomic bases of phenotypic plasticity and the study of the genomic bases of adaptation and speciation"-- Publisher's description.
  • Disturbance, survival, and succession : understanding ecological responses to the 1980 eruption of Mount St. Helens / Virginia H. Dale, Frederick J. Swanson and Charles M. Crisafulli -- Geological and ecological settings of Mount St. Helens before May 18, 1980 / Frederick J. Swanson, Charles M. Crisafulli and David K. Yamaguchi -- Physical events, environments, and geological-ecological interactions at Mount St. Helens : March 1980-2004 / Frederick J. Swanson and Jon J. Major -- Plant responses in forests of the tephra-fall zone / Joseph A. Antos and Donald B. Zobel -- Plant succession on the Mount St. Helens debris-avalanche deposit / Virginia H. Dale ... [et al.] -- Geomorphic change and vegetation development on the Muddy River mudflow deposit / Peter M. Frenzen ... [et al.] -- Proximity, microsites, and biotic interactions during early succession / Roger del Moral, David M. Wood and Jonathan H. Titus -- Remote sensing of vegetation responses during the first 20 years following the 1980 eruption of Mount St. Helens : a spatially and temporally stratified analysis / Rick Lawrence -- Arthropods as pioneers in the regeneration of life on the pyroclastic-flow deposits of Mount St. Helens / John S. Edwards and Patrick M. Sugg -- Posteruption arthropod succession on the Mount St. Helens volcano : the ground-dwelling beetle fauna (Coleoptera) / Robert R. Parmenter ... [et al.] -- Causes and consequences of herbivory on prairie lupine (Lupinus lepidus) in early primary succession / John G. Bishop ... [et al.] -- Responses of fish to the 1980 eruption of Mount St. Helens / Peter A. Bisson ... [et al.] -- Amphibian responses to the 1980 eruption of Mount St. Helens / Charles M. Crisafulli ... [et al.] -- Small-mammal survival and colonization on the Mount St. Helens volcano : 1980-2002 / Charles M. Crisafulli, James A. MacMahon and Robert R. Parmenter -- Mycorrhizae and Mount St. Helens : story of a symbiosis / Michael F. Allen ... [et al.] -- Patterns of decomposition and nutrient cycling across a volcanic disturbance gradient : a case study using rodent carcasses / Robert R. Parmenter -- Lupine effects on soil development and function during early primary succession at Mount St. Helens / Jonathan J. Halvorson, Jeffrey L. Smith and Ann C. Kennedy -- Response and recovery of lakes / Clifford N. Dahm ... [et al.] -- Ecological perspectives on management of the Mount St. Helens landscape / Virginia H. Dale, Frederick J. Swanson and Charles M. Crisafulli -- Overview of ecological responses to the eruption of Mount St. Helens : 1980-2005 / Charles M. Crisafulli, Frederick J. Swanson and Virginia H. Dale.
  • Ecological studies v. 1-, 1970-
  • Recent work on the human microbiome represents the essence of community ecology: "What makes assemblages of species more or less similar to each other at different places and times?" (Vellend 2010; Anderson et al. 2011). The complex microbial communities of the human subgingival crevice are particularly relevant since multiple, spatially distinct but ecologically similar sites are found in a single subject. Healthy sites and sites affected by periodontitis (gum disease) can coexist in the same mouth simultaneously; periodontal disease may reflect community processes since it is thought to have a polymicrobial etiology rather than a single species etiology in the tradition of Koch's postulates. Subgingival communities therefore provide a unique, clinically relevant context to apply ecological concepts. The goal of this work was to advance our ecological understanding of the human subgingival microbiota, drawing on two fields of ecological research: biogeography and the stability of complex communities. The first half of this work explored oral biogeography and treating subgingival sites as isolated, island-like patches of similar habitat distributed within a mouth. A survey of twenty-three to thirty subgingival sites per mouth within five periodontally healthy subjects uncovered non-random, spatially relevant patterns of community distributions. Specifically, a left-right symmetric pattern of community similarity and a positive correlation between physical distance between sites and the dissimilarity of their respective communities were observed. However, these patterns were only discernable among deeply sequenced communities. Additional applications of co-occurrence analysis and neutral theory models to the data indicated that both competitive interactions and stochastic, demographic processes influence distributions of subgingival taxa. The second half of this work assessed the temporal stability of health and periodontitis-associated subgingival and salivary microbial communities before and after a single disturbance event of professional teeth cleaning. Communities were surveyed in 8 subjects (4 healthy, 4 with moderate chronic periodontitis), at 4 sites per subject, and at four sampling times ranging from 2 weeks to 1 day before the cleaning to assess baseline spatial and temporal variation. Samples collected at seven time points ranging from 1 hour to 3 months after the cleaning were also examined in order to monitor the compositional response to the perturbation. The results of this work demonstrated that healthy and periodontitis-associated subgingival communities are resilient to a teeth-cleaning perturbation, but the displacement of community composition immediately after cleaning was greater in periodontitis than in health. Periodontitis-associated subgingival communities more closely resembled a health-like composition as they recovered from the cleaning, although this change was transient. Salivary communities were also shown to be resilient to a teeth cleaning perturbation, but the impact of the cleaning on community composition is less pronounced in saliva. The results further suggest that post-cleaning residual subgingival communities contribute more to subgingival recolonization than salivary communities. The results of this work generated testable hypotheses about the ecological mechanisms governing observed spatial and temporal patterns. I hope these findings will contribute to the development of novel, ecologically informed approaches to the clinical treatment of the subgingival environment.
  • Human immunodeficiency virus (HIV) is a significant problem worldwide as well as in the United States (US), despite ongoing efforts to limit HIV transmission. In the US, men who have sex with men (MSM) account for over half of new HIV infections every year, and thus are an important group to consider for HIV interventions. Both prevention and treatment options are available to combat HIV transmission, but decision makers must prioritize among the available disease control strategies. Mathematical modeling frameworks can be used to assess the value and efficiency of various disease control measures and help inform resource allocation decisions. This dissertation describes research on economic analysis of HIV prevention and treatment portfolios, primarily for MSM in the US. We develop two independent mathematical modeling frameworks, both intended to assist decision makers with minimizing HIV transmission in the most cost-effective manner. First, in Chapter 2, we present a dynamic compartmental model of the HIV epidemic that we built and instantiated for MSM in the US. This model can be used to assess the effectiveness and cost-effectiveness of prevention and treatment programs for MSM. In particular, in Chapter 3 we examine testing for and treating acute HIV infection, and in Chapter 4 we examine preexposure prophylaxis for HIV prevention. We find that symptom-based testing for acute HIV infection is cost-effective for MSM in the US, but incorporating testing for acute infection into the standard HIV screening protocol is not. For preexposure prophylaxis, we find that it is not cost-effective for the general MSM population, but it provides good value in high-risk MSM. In Chapter 5, we present a resource allocation framework for determining the optimal mix of HIV treatment and prevention programs, given a fixed budget. We develop methods of linearly estimating health benefits and costs that account for epidemic effects of reducing disease transmission. We illustrate our model with the examples of preexposure prophylaxis and community-based education compared with antiretroviral therapy for MSM in the US. We show both analytically and with the examples that HIV budgets are often best spent on the program that offers the greatest "bang for the buck.".
  • The magnitude of the problem of malnutrition in Europe / Kondrup, J. -- Malnutrition in North America : where have we been? Where are we going? / Jensen, G. -- The economics of malnutrition / Elia, M. -- The need for consistent criteria for identifying malnutrition / Hoffer, J. -- Enteral nutrition reimbursement : the rationale for the policy : the US perspective / Parver, A.K. -- Enteral nutrition reimbursement : the rationale for the policy : the German perspective / Pahne, N. -- Food modification versus oral liquid nutrition supplementation / Silver, H. -- Cost-effectiveness analysis and health policy / Torgerson, D. -- Implementing nutritional standards : the Scottish experience / McKinlay, A. -- Innovative models for clinical nutrition and financing / Van Emelen, J. -- ENHA : what is it and what does it do? Reimbursement is not the solution / De Man, F. -- Brief history of parenteral and enteral nutrition in the hospital in the USA / Bistrian, B. -- What went right? The story of US Medicare medical nutrition therapy / Patrick, S.
  • The book presents a basic introduction to epidemiology from the perspective of economics, using economic modeling to better understand and describe how infectious disease spreads. Three main elements are introduced: epidemiology, social network analysis, and the economics needed to model the behavior of individuals in the presence of infectious disease. The book aims to provide a starting point for discussion between medical professionals, social scientists and public health officials, the three groups interested in the spread of disease.
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    "In response to the growing concern about equity issues and their implications for overall development, WHO established the Commission on Social Determinants of Health (CSDH) in 2005, which focused on the "social justice" or human rights arguments for health investments. CSDH investigated the factors involved in the so-called "social gradient in health", which refers to the large observable differences in health outcomes within and between countries that are determined by avoidable inequalities in the access to resources and power. CSDH aimed to further investigate the causes of health inequities, with a deliberate detachment from economic considerations, and provide advice on how to tackle them effectively. CSDH also reviewed evidence for action on a wider scope of interventions than CMH, many of which require intersectoral collaboration or advocacy. With CMH and CSDH having adopted different but perhaps complementary standpoints, it soon became clear that greater synergies had to be forged between the two. This WHO resource book on the economics of social determinants of health and health inequalities seeks to begin to build a bridge between the two approaches by explaining, illustrating and discussing the economic arguments that could (and could not) be put forth to support the case for investing in the social determinants of health on average and in the reduction in socially determined health inequalities. The resource book has two main objectives: -- to provide an overview and introduction into how economists would approach the assessment of the economic motivation to invest in the social determinants of health and socially determined health inequities, including what the major challenges are in this assessment; -- to illustrate the extent to which an economic argument can be made in favour of investment in three major social determinants of health areas: education, social protection, and urban development and infrastructure."--WHO website
  • EcoSal 2004
    Am Soc Microbiol
    An archive of the entire corpus of knowledge on the enteric bacterial cell, comprised of several hundred modules of information and interpretation, including the genome database.
  • Exploring the linkages between ecosystems and human health -- Evolution towards an ecosystem approach to public health -- Ecosystem approaches to human health: key concepts and principles -- Community-based participatory research for ecohealth -- The process of conducting an ecohealth research project: a participatory action research approach -- Applying an ecosystem approach to community health research in Ghana: a case study -- Planning for a healthy community: a case study: phase II -- Challenges and ethical dilemmas in conducting participatory ecohealth research -- Ecosystem approaches to indigenous health -- Policy frameworks on health and environmental linkages -- Applying critical theory to environmental and health issues -- Examining environmental problems from a critical perspective -- Examining public health concerns from a critical perspective -- Towards a critical approach to ecohealth research and practice.
  • "The third edition of a bestseller, this book describes how chemical toxins and biological hazards impact the environment and people. Addressing how pollutants can alter the environment by contributing to global climate change, the author explores a broad range of environmental and health aspects of chemical and biological hazards. He includes numerous examples of the intimate relationship between ecosystem health and human health and emphasizes the need to consider this relationship whenever human activities are likely to have a significant environmental impact"-- Provided by publisher.
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    Why do ecosystems matter to human health? -- How have ecosystems changed and what are the health implications? -- What actions are required to address the health consequences of ecosystem change? -- How can priorities be established for actions to address the health consequences of ecosystem change? -- What are the policy implications of the most robust findings and key uncertainties?
  • I. Hierarchical ecotoxicology. The hierarchical science of ecotoxicology -- II. Organismal ecotoxicology. The organismal ecotoxicology context -- Biochemistry of toxicants -- Cells and tissues -- Organs and organ systems -- Physiology -- Bioaccumulation -- Models of bioaccumulation and bioavailability -- Lethal effects -- Sublethal effects -- Conclusion -- III. Population ecotoxicology. The population ecotoxicology context -- Epidemiology : the study of disease in populations -- Toxicants and simple population models -- Toxicants and population demographics -- Phenogenetics of exposed populations -- Population genetics : damage and stochastic dynamics of the germ line -- Population genetics : natural selection -- Conclusion -- IV. Community ecotoxicology. Introduction to community ecotoxicology -- Biotic and abiotic factors that regulate communities -- Biomonitoring and the responses of communities to contaminants -- Experimental approaches in community ecology and ecotoxicology -- Application of multimetric and multivariate approaches in community ecotoxicology -- Disturbance ecology and the responses of communities to contaminants -- Community responses to global and atmospheric stressors -- Effects of contaminants on trophic structure and food webs -- Conclusions -- V. Ecosystem ecotoxicology. Introduction to ecosystem ecology and ecotoxicology -- Overview of ecosystem processes -- Descriptive approaches for assessing ecosystem responses to contaminants -- The use of microcosms, mMesocosms, and field experiments to assess ecosystem responses to contaminants and other stressors -- Patterns and processes : the relationship between species diversity and ecosystem function -- Fate and transport of contaminants in ecosystems -- Effects of global atmospheric stressors on ecosystem processes -- VI. Ecotoxicology : a comprehensive treatment--conclusion -- Conclusion.
  • "ENOX Proteins" documents a unique family of cell surface proteins which are the exclusive discovery (subsequently confirmed by others) of the authors, their students and their colleagues. An ENOX-based mechanism is provided for how cells increase in size that is both unique and applicable not only to cancer and cancer therapy but also to production agriculture and biomass increase. The role of ENOX proteins in biological time-keeping is described along with evidence for oscillations in the ratios of electron spin pairs defining ortho and para water states that form highly coordinated populations of coherent water of interest to physicists as the underlying mechanism. The age-related NADH oxidases that appear around age 30 and increase steadily thereafter with potentially causal involvements in atherogenesis and skin aging have been identified as five members of the TM-9 protein superfamily of all with different chromosomal locations. The arNOX proteins initially are membrane anchored but functionally-active N-terminal fragments that are shed into body fluids. Except for critical functional motifs, all of the ENOX protein family members have distinct protein sequences and chromosomal origins. A fourth member of the ENOX protein family occurs in plants as the primary target for both natural and synthetic growth hormone (auxin)-stimulated rapid cell enlargement. Despite masquerading as intractable and difficult to clone and characterize, ENOX proteins offer remarkable opportunities for research, commercial development and outside confirmation of new paradigms to help explain complex biological processes.
  • Comprised exclusively of clinical cases covering ectopic pregnancy, this concise, practical casebook will provide clinicians in reproductive medicine and obstetrics/gynecology with the best real-world strategies to properly diagnose and treat the various forms of the condition they may encounter. Each chapter is a case that opens with a unique clinical presentation, followed by a description of the diagnosis, assessment and management techniques used to treat it, as well as the case outcome and clinical pearls and pitfalls. Cases included illustrate different management strategies ? from treatment with methotrexate to surgical interventions ? as well as types of ectopic pregnancy, such as ovarian, interstitial, heterotopic and abdominal forms, among others. Pragmatic and reader-friendly, Ectopic Pregnancy: A Clinical Casebook will be an excellent resource for reproductive medicine specialists, obstetricians and gynecologists, and family and emergency medicine physicians alike.
  • Introduction -- When does a human being become a person? -- All human beings are persons -- How is the dignity of the person as agent recognized? Distinguishing intention from foresight -- An ethical assessment of Bush's guidelines for stem cell research -- Moral absolutism and ectopic pregnancy -- Could artificial wombs end the abortion debate? -- Solomon's dilemma: should conjointed twins Jodie and Mary have been separated? -- Capital punishment and the Catholic tradition: contradiction, circumstantial application, or development of doctrine?
  • v. 1. Fruits -- v. 2. Fruits -- v. 3. Fruits -- v. 4. Fruits -- v. 5. Fruits -- v. 6. Fruits -- v. 7. Flowers -- v. 8. Flowers
  • Also available: Print – 2010
    Based on a study of physician education by the Carnegie Foundation for the Advancement of Teaching. Calls for a major overhaul of the present approach to preparing doctors for their careers. The text addresses issues for the future of the field and takes a comprehensive look at the most pressing concerns in physician education today.-- excerpted from publisher notes.
  • Also available: Print – 2015
    1. Introduction -- 2. Characterizing physicians' information needs at the point of care -- 3. Access of primary and secondary literature by health personnel in an academic health center : implications for open access -- 4. Evidence-based medicine training in undergraduate medical education : a review and critique of the literature published 2006-2011 -- 5. Challenges to learning evidence-based medicine and education approaches to meet them : a qualitative study of selected EBM curricula in North American medical schools -- 6. Designing evidence-based medicine training to optimize transfer of skills from the classroom to clinical practice : apply the Four Component Instructional Design Model -- 7. Discussion.
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    Health care from the inside out : bringing the self of the healer into the practice of medicine : an interview with Parker J. Palmer / Marcy Jackson -- From freedom to learn to freedom to innovate : the Harvard Macy Institute story / Elizabeth J. Armstrong with Sylvia Barsion -- Facilitating the effectiveness of medical teachers : improving teaching through faculty development / Kelley M. Skeff, Georgette A. Stratos -- Education of a teacher / William T. Branch Jr. -- Influencing the culture of educational assessment in academic health science centers / Eric Holmboe, William Iobst -- A quality improvement management model for curriculum evaluation and integration / Thomas R. Viggiano -- The dissemination of relationship-centered care approaches to enhance the informal curriculum of academic health science centers / Ann H. Cottingham [and others] -- Partners in global health medical education : learner-centered curriculum in resource-poor environments / Paul O. Ayuo, [et al.] -- An academic health science center's journey toward teaching and delivering patient-centered care / Dale Smith -- The power of doing meaningful work together / Shirley M. Moore -- Reforming medical education : confessions of a battered humanist / DeWitt C. Baldwin Jr. -- Concluding reflections on creating enduring change / Linda A. Headrick, Ann H. Cottingham, Debra K. Litzelman.
  • Contains a database of approximately 70,000 reactions and 4000 of the most frequently consulted reagents. Fully searchable by structure and sub-structure, reagent, reaction type, experimental conditions, and keyword. Also includes a searchable interface: Acronym finder (an interface for Scientific and technical acronyms, symbols, and abbreviations).
  • Effective Java. 2nd ed. 2008
    ProQuest Safari
    Introduction -- Creating and destroying objects -- Methods common to all objects -- Classes and interfaces -- Generics -- Enums and annotations -- Methods -- General programming -- Exceptions -- Concurrency -- Serialization.
  • Understanding migraine and pregnancy -- Safety rating systems for drugs used in pregnancy and lactation -- Non-pharmacological headache treatments -- Acute treatment options for the pregnant headache patient -- Acute treatment options for the lactating headache patient -- Preventive treatment options for the pregnant headache patient -- Preventive treatment options for the lactating headache patient -- Urgent care/emergency treatment of the acute, severe headache in pregnant and lactating patients -- Work-up for headache during pregnancy and lactation -- Patient headache resources.
  • This book explains how training in arthroscopic skills is best carried out in order to keep up to date with advances in arthroscopy, meet the ever-increasing demand for high-quality care, and respond to changes in available training time. State of the art developments regarding tools, performance monitoring, and learning strategies are presented, and practical guidelines provided for direct implementation in daily clinical practice. The coverage of simulation-based training ranges from the use of wet labs and box trainers through to sophisticated virtual reality simulators. Subsequent sections on objective performance tracking of training outside and in the operating room cover a variety of key aspects, including psychomotor learning, the adequacy of performance measures, evidence-based thresholds, preclinical training strategies, the role of global rating scales, and video tools. As a result of the success of arthroscopy, its role in the orthopaedic armamentarium is continuously increasing and ever more complex surgeries are being performed arthroscopically. Effective training in arthroscopy is essential to good outcomes. The guidance provided in this book by acknowledged experts in the field will assist in improving the efficiency and effectiveness of arthroscopic training and in enhancing patient safety.
  • Print Material
  • Rupture of the anterior cruciate ligament (ACL) is one of the most common injuries to the knee. Unfortunately, individuals who experience this injury are likely to develop osteoarthritis of the knee much earlier than would be expected due to the normal ageing process, and this remains true even after surgical reconstruction of the ligament. Research has suggested that a major contributing factor to the development of premature osteoarthritis is altered knee mechanics which change the loading conditions of the cartilage in the joint. Furthermore, it has been shown that altered knee mechanics are present following rupture of the ACL and persist after reconstruction surgery. Despite initial reports, there still remains a need for a comprehensive understanding of both altered knee mechanics in both ACL deficient and ACL reconstructed knees as well as changes in cartilage morphology following ACL injury. Therefore, the goal of this dissertation is to address the question of the relationship between certain changes in knee mechanics and cartilage morphology as they relate to the development of osteoarthritis following both ACL injury and reconstruction. The first study presented involves an analysis of the knee mechanics in individuals with unilateral ACL deficiencies. This group was important in that they were free of knee pain and had no sign of osteoarthritis on MRI over a time frame that ranged up to three decades from injury. This provided a unique opportunity to explore the potential for a protective functional adaption. The results of this study suggest that alteration in knee mechanics may act as a protective mechanism against osteoarthritis development since when subjects were separated into "Short Term" and "Long Term", based upon the time from injury, only those in the "Long Term" group demonstrated a relationship between the external knee flexion moment, which is representative of the interaction between quadriceps and hamstrings muscle to control rotation and translation during walking. This is indicative of an adaptive control mechanism present in some subjects who were able to last many years after the injury without reconstruction surgery. These results suggest the potential for new methods for rehabilitation following ACL injury. The second study presented involves an analysis of the knee mechanics of individuals with unilateral ACL reconstructions during gait, stair ascent, and stair descent at two years from surgery. The results demonstrate a reduction in the external joint moments of ACL reconstructed knees and an increase in the joint moments of uninjured contralateral knees during each activity compared to healthy controls. This suggests two things: 1.) compensation for residual muscle weakness in the affected limb is needed by the contralateral knee during ambulation and 2.) a decrease in daily joint loading in ACL reconstructed knees and an increase in joint loading in contralateral knees. Decreased loading of the ACL reconstructed knee may seem counterintuitive to what was expected in patients who will likely develop premature osteoarthritis in this knee. However, this finding is consistent with the suggestion that changes in joint kinematics and even decreased joint loading following the injury may contribute to the initial cartilage breakdown. Note: Taken together the results of study 1 and 2 suggest that the interaction between muscle function and kinematics should be further considered in the development of knee OA in this population. The third and final study involves articular cartilage morphology analysis of individuals with unilateral ACL reconstructions at two and four years from surgery. The results illustrate differences between cartilage thickness of ACL reconstructed and healthy contralateral knees at both times of testing. The findings show significantly thinner cartilage in the lateral tibial compartment of ACL reconstructed knees at two years from surgery. These differences became more pronounced at four years from surgery and include the addition of a significantly thicker medial region of the tibia of ACL reconstructed knees compared to healthy contralateral knees. The results indicate that patterns of cartilage thickness change are detectable as early two years following ACL reconstruction, and these patterns become more pronounced at 4 years which suggests cartilage begins a degenerative pathway substantially in advance of clinically detectable OA. This finding is important since it provides a basis for assessing early interventions to reduce the risk of knee OA following ACL injury. This dissertation helps to further the understanding of altered knee mechanics following both ACL rupture and reconstruction. In addition, a possible pattern of OA initiation has been reported. Each of these studies will benefit future studies with the ultimate goal of a complete understanding of OA initiation and development in ACL ruptured and reconstructed knees.
  • Drug use and abuse continues to thrive in contemporary society worldwide and the instance and damage caused by addiction increases along with availability. The Effects of Drug Abuse on the Human Nervous System presents objective, state-of-the-art information on the impact of drug abuse on the human nervous system, with each chapter offering a specific focus on nicotine, alcohol, marijuana, cocaine, methamphetamine, MDMA, sedative-hypnotics, and designer drugs. Other chapters provide a context for drug use, with overviews of use and consequences, epidemiology and risk factors, genetic.
  • Print Material
    Preclinical data relating to estrogen's effects on cognitive performance / Robert B. Gibbs -- The short-lived effects of hormone therapy on cognitive function / Eva Hogervorst -- Clinical data from structural and functional brain imaging on estrogen's effects in the central nervous system / Daniel H.S. Silverman, Cheri L. Geist, and Natalie L. Rasgon -- Clinical data on estrogen's effects on mood / Natalie L. Rasgon, Laurel N. Zappert, and Katherine E. Williams -- Preclinical efforts to develop effective neuroSERMs for the brain / Roberta Diaz Brinton and Liqin Zhao -- Basic and clinical data on the effects of SERMs on cognition / Kristine Yaffe, Pauline M. Maki, and Peter J. Schmidt.
  • The project reported here, sponsored by the American Medical Association (AMA), aimed to describe the effects that alternative health care payment models (i.e., models other than fee-for- service payment) have on physicians and physician practices in the United States. These payment models included capitation, episode-based and bundled payment, shared savings, pay for performance (PFP), and retainer-based practice. Accountable care organizations and medical homes, which are two recently expanding practice and organizational models that are based on one or more of these alternative payment models, were also included. Project findings are intended to help guide efforts by the AMA and other stakeholders to make improvements to current and future alternative payment programs and help physician practices succeed in these new payment models--i.e., to help practices simultaneously improve patient care, preserve or enhance physician professional satisfaction, satisfy multiple external stakeholders, and maintain economic viability as businesses
  • T cells will usually recognize any pathogen that threatens the body, despite the many different and constantly changing forms these pathogens can take. This is accomplished by the enormous diversity of T-cell receptors that are randomly generated during T-cell maturation. There are a number of distinct mechanisms that drive this diversity: one is the recombination of gene segments, (designated V, D, and J), from pools of many possible gene segments. Another is the addition and deletion of nucleotides at the gene segments joints (between the V, D, and J segments). This yields ~10^15 different possible T-cell receptors, which is many times greater that the number of T cells in the periphery of either mice (~10^8) or humans (~10^11). The T-cell receptor is formed from two polypeptide chains, α and β, each derived from separately rearranged gene segments. Each chain is composed of semi-randomly chosen gene segments. We utilized three transgenes, one limiting the α chain and two limiting the β chain. These progressively limited the number available gene segments of 100 Vα's to 1; 50 Jα's to 2; 30 Vβ's to 1; 2Dβ's to 1 and 13 Jβ's to 2. This reduced the number of gene segment combinations from a theoretical 3,900,000 to 4 combinations. The addition and deletion of nucleotides at the gene segment joints is unaffected. In an in vivo CTL killing assay, the mice with these limited T cell repertoires are able to recognize most but not all of the antigenic peptides tested (9 of 11, in the most restricted mice). Their immunity to Listeria monocytogenes was reduced somewhat; but the LD50 of Yersinia pseudotuberculosis was not diminished by limiting T-cell repertoire, and viral load after murine cytomegalovirus infection was similar to wild type. The limited repertoire mice also exhibited less vigorous alloreactive responses to some haplotypes, indicating that alloreactive responses are influenced by V gene segment compatibility with the MHC. We conclude that N and P nucleotide addition is sufficient for the bulk of T-cell immunity, at least in the laboratory setting. Limiting V(D)J gene segment choice, despite eliminating some T-cell specificities, does not have a dramatic effect on T-cell immunity.
  • The development of atherosclerosis, a chronic inflammatory disease of the arteries, can usually be attributed to specific regions of the blood vessel. In the straight segments of an artery, endothelial cells (ECs) align with the unidirectional blood flow which commonly occurs in these simple geometries. The elongated and aligned ECs are generally found to have a healthy, athero-resistant phenotype. In contrast, branches or curved vessel geometries have regions of disturbed flow, characterized by low shear stress and high shear stress gradients. In these regions of complicated flow patterns, ECs are non-aligned and have a cobblestone cellular morphology. The non-aligned ECs elicit biological properties that promote atherosclerosis, as the location of atherosclerotic fatty plaque is often found at these bends, branches, or bifurcations. Therefore, this correlation highly suggests that the morphology and biological function are inextricably linked in ECs. The ability to regulate both EC morphology and motility, with the aim to influence EC biology, might be highly beneficial in the prevention or treatment of vascular disease. In this dissertation, anisotropic matrices of collagen nanofibrils were fabricated with a simple flow processing technique and used to investigate fundamental cell-matrix interactions with ECs. The aligned fibrils were able to regulate both the morphology and biology of ECs, thereby suggesting the nanofibrillar collagen can be a useful tool to maintain vascular homeostasis. The ECs elongated and organized their actin cytoskeleton along the direction of the aligned collagen fibrils, as demonstrated by organized actin, microtubule networks, and focal adhesions. The nanofibrillar collagen also promoted increased cellular migration along the direction of the nanofibrils. The quantification of monocyte adhesion and expression level of adhesion molecules, known testing indicators of atherosclerosis development, suggested the aligned nanofibrils also promoted an athero-resistant phenotype in the ECs. ECs are subject to biophysical cues in vivo, either in the form of surface topography (provided by the basement membrane of the ECM) or the hemodynamic effects of blood flow. The combination of these cues regulate the organization and immunogenicity of ECs and is representative of the in vivo environment. Therefore, we also investigated the endothelial behavior when both types of cues (topography and flow) were simultaneously present. At physiological levels of high shear stress (14-17 dynes/cm2), the matrix-aligned ECs were able to resist reorientation despite shear flow perpendicular to the matrix direction. The anisotropic collagen matrix could preserve the alignment and elongation of ECs as well as promote an athero-resistant phenotype after exposure to antagonistic perpendicular flow. The ability of the anisotropic nanofibrillar collagen to regulate cell morphology and especially EC immunogenicity highlights its potential in the treatment of vascular diseases. Therefore, an aligned conduit of collagen nanofibrils was fabricated to address the need for a small-diameter vascular graft capable of regulating cellular function. The vascular graft was designed to have a mechanical integrity comparable to that of native vessels and was able to regulate EC attachment, morphology, and phenotype. In addition, the aligned collagen grafts could support an anti-thrombogenic surface modification, providing short-term patency in the carotid artery model of Sprague-Dawley rats.
  • Also available: Print – 2012
    Part I. Introduction -- Part II. Sound Detection by Aquatic Animals -- Part III. Sound Production by Aquatic Animals -- Part IV. Physiological Effects of Sounds -- Part V. Anthropogenic Sounds and Behavior -- Part VI. Population Effects -- Part VII. Anthropogenic Sound Sources and Their Measurement -- Part VIII. Science, Regulation and Sound Exposure Criteria -- Part IX. Monitoring, Management and Mitigation -- Part X. Workshops and Concluding Remarks.
  • In the last 100,000 years, humans have been subjected to multiple different evolutionary pressures. Migration events, changing food sources, climate change, and technological advances are some of the ways environmental changes have applied pressure on human populations to undergo change. Recent advances in methods to measure differences in DNA sequences have led to new powerful techniques to measure the effect of evolution on different human populations. Also due to the availability of recent explosion of genomic data, our understanding of genetic basis of human disease has grown significantly. However, our knowledge regarding the effect that recent evolution has had on the genetic susceptibility to disease has grown to a much lesser extent. There is a lack of studies attempting to place the genetic basis of disease in the context of recent evolutionary changes. I describe multiple ways in which recent evolutionary pressures on the human genome can lead to insights to understanding how evolution has impacted complex disease. I show that GWAS (Genome-Wide Association Studies) are particularly well suited to measure the effect of recent evolution in complex disease. I provide methodology to detect positive selection in human disease and are able to ascertain whether recent evolution has disproportionately increased or decreased the risk of inherited disease. In addition, I introduce a method to approximate when and where genetic risk differentiation for specific disease has occurred, starting when humans began migration out of Africa. Environmental changes in the last 10,000 years known to have created novel, diverse, and pervasive pathogens. I provide methodology to find positive selection in communicable disease. I identify populations that have most likely been severely impacted by specific pathogens in recent human history. I develop and apply methods to identify specific genetic variants important to both communicable and inherited disease that have been affected by evolutionary pressures. I find that type 1 diabetes has recently undergone strong positive selection towards increasing genetic risk in European derived populations. In addition type 2 diabetes and pancreatic cancer is associated with migration trajectories and I find genetic risk differentiation exceeding what is expected by genetic drift in a total of 11 complex diseases. Finally, I find evidence of positive selection in many distinct populations within proteins interacting bacillus anthracis and yersinia pestis, which cause anthrax and the bubonic plague, respectively. I have shown how recent evolution can lead to an increased understanding of both inherited and infectious disease.
  • The bryostatins are a family of structurally complex natural products isolated from the marine bryozoan Bugula neritina. Bryostatin 1 is currently being investigated for cancer, Alzheimer's and HIV/AIDS indications. Despite these remarkable activities, research on the bryostatins is hampered by their low natural abundance. Efficient access by total chemical synthesis has been in large part precluded by the bryostatins' structural complexity. This dissertation describes the design, synthesis, and preliminary biological evaluation of functional bryostatin analogs that possess biological activities comparable or superior to the natural product. These fully synthetic analogs were convergently assembled in a uniquely step-economical manner using novel macrocyclization strategies, including macroacetalization and Prins-driven macrocyclization approaches. Bryostatin analogs were identified that possess unique affinities (subnanomolar) and selectivities for protein kinase C (PKC). Synthetic bryostatin analogs also exhibit subnanomolar antileukemic activity in in vitro assays. The convergent total synthesis of bryostatin 9, a highly potent congener of the natural product family, is also described.
  • The heart is an essential heterogeneous organ that depends on strong coupling between electrical, chemical, and mechanical dynamics to properly function as a pump that supplies blood to the rest of the body. Cardiac arrhythmias are common disorders characterized by irregular beating of the heart that lead to serious clinical conditions. It is estimated that approximately 2.2 million adults in the United States are affected by atrial fibrillation, a prevalent arrhythmia. Unfortunately, a clinician often does not have enough information to diagnose a patient's heart condition to determine the optimal treatment procedure. This is an area that computational mechanics can address. While development of mechanical and electrophysiological models of cardiac tissue primarily started in the 1950s, fully-coupled models have only more recently been developed due to factors regarding computational cost, difficulty in quantifying material properties, and difficulty in integrating complex models in a cohesive and efficient manner. Therefore, in order for simulation tools to have impact in the clinical or experimental setting, these tools must be efficient, fast, robust, and accessible. The focus of this thesis is to develop methods of addressing the aforementioned issues and then illustrate how efficient electromechanical finite element models can be developed for the heart such that their use in the clinical and experimental setting can be realized in several examples. In this thesis, a global-local variable splitting formulation borrowed from the field of plasticity is used to address the issues of complex model integration, and to maintain numerical stability at low costs. Through careful examination of classical phenomenological models and detailed biophysical ionic models of the electrophysiology of the heart, almost all models can be reformulated into this global-local splitting framework. The numerical properties of cost-expensive ionic models are briefly analyzed within the context of this framework. Use of implicit-time stepping in tandem with a simple iteration and error tolerance based adaptive time-stepping algorithm allows for reduction of computation time from hours to minutes. Flexibility and modularity of the framework are illustrated through the development of electrical, electro-chemical, electro-chemical-mechanical, and opto-electro-mechanical models of cardiac tissue. The heart is modeled efficiently using custom finite element ventricular cell models for physiological electrical simulations and large deformation excitation-contraction dry-pumping simulations of the heart. The results accurately model the physiological condition of the heart. The flexibility and multiscale nature of the framework is also leveraged in developing novel optical-induced cardiac cell excitation models of new genetically engineered Channelrhodpsin-2 (ChR2) cardiac myocytes. An ionic model was developed for these particular bio-engineered stem cells, calibrated with experimental data from collaborators, and was able to predict the electrical excitation behavior of the cells to a reasonable degree of accuracy. This model was then combined with ionic pacemaker cell models and also with ventricular cell models into respective finite elements to simulate experiments and predict future therapies using ChR2 genetically modified cardiac tissue. The thesis also addresses difficulties relating to identification and characterization of material parameter identification in inhomogeneous cardiac tissue. Metrics for determining smoothness in electrical conduction in tissue cultures were validated with stochastic finite element models of microelectrode array cell conduction experiments. The results indicate that these metrics are useful in characterizing different conduction patterns based on two metrics borrowed from texture analysis. Difficulties in obtaining structural fiber data from clinical images were addressed by developing an algorithmic method for designating approximate physiologically accurate fiber distributions for the heart using only geometrical information obtained from MRI scans of the surfaces of the heart. Poisson interpolation is used and results in a smooth continuous rotating fiber description that matches experimentally obtained fiber directions from MRI scans. The main benefits of this algorithm are its simplicity of implementation, physiologically accuracy, and generality in interpolating fiber distributions. Lastly, the thesis demonstrates possible benefits of GPU computing in order to achieve near-real-time electrical simulations of arrhythmias in the heart. The assembly and solver routines from the finite element code, FEAP from Berkeley, were ported to the GPU using CUDA. Even with a minimally optimized proof-of-concept, the GPU-only finite element code achieves performance comparable to twelve cores using only one GPU. To increase the overall efficiency of the method, current sparse matrix vector multiplication GPU algorithms are analyzed, and possible alternative algorithms are developed specifically with unstructured finite element meshes in mind. Altogether, the different methods developed in this thesis have been shown to be effective in addressing issues related to efficiency, numerical stability, modularity, and flexibility in real computational applications of the heart. Special consideration was taken in designing the different methods to be compatible with one another, such that a majority of the methods could be integrated and the benefits of each method could be leveraged with each other to gain maximum efficiency. While these developed methods can still be improved, the thesis work as a whole serves to demonstrate and highlight future uses for computational models within experimental and clinical settings.
  • The central theme of this work revolves around the genetics of admixed individuals---individuals who derive their ancestry from two or more different ancestral populations.The genomes of admixed individuals exhibit unique properties that make them both fascinating and challenging to study using existing statistical methods. Their uniqueness lies in their block-like structure, a feature that is the direct result of generations of recombination events. An important advance in the field of admixture genetics has been the development of algorithms capable of determining the ancestry of different regions in the admixed genome. As we will illustrate in this work, local ancestry information can readily be harnessed towards the investigation of subcontinental structure, by which we attempt to determine the specific ancestral populations that gave rise to the admixed genomes under study, and whether differences exist in the ancestral makeup of these admixed samples. The latter line of investigation is of particular relevance to genome-wide association studies, which are prone to confounding if structure in a population has not been explicitly corrected for. This work is thus divided into three parts. We first apply some straightforward multivariate statistical methods such as PCA to gain insights into the African ancestry of African Americans. To this end, we introduce a novel method for the study of specific components of admixture in admixed individuals. We then expand on this work to introduce more sophisticated algorithms for the study of admixed genomics. These methods entail the development of an improved method for local ancestry deconvolution, and the implementation of a PCA approach designed to handle large amounts of missing data. We illustrate the power of using these methods in conjunction with one another with the study of two Latino populations. Finally, we describe a novel phasing algorithm designed to incorporate sequencing information into the process of haplotype reconstruction---an important upstream step for many of the analyses described here.
  • We present models and algorithms that can be applied to common problems in analysis of genomic data. These include CNV (Copy Number Variation) detection, local ancestry inference in admixed populations, and haplotype inference in panels of unrelated individuals. Chapter 2 proposes a new algorithm for the Fused Lasso Signal Approximator which was recently been proposed as an alternative to HMM's for CNV detection. Chapter 3 describes new models for local ancestry inference when high density genotype data is available, and our focus is on a higher order Autoregressive Hidden Markov Model (ARHMM). We give solutions to problems that have thus far prevented the use of higher order ARHMM's for this task, and we demonstrate the model on real and simulated data. Finally, in chapter 4 we given an approach for inferring haplotypes from unphased genotype data. We optimize a likelihood closely related to the PHASE model (which is considered one of the most accurate), and we show that the proposed approach is substantially more accurate than recent alternatives. The work in these chapters contributes to common and important tasks in analysis of genomic data for association studies.
  • EGFR inhibitors in cancer treatment / Fortunato Ciardiello -- Mechanisms of action of EGFR inhibitors / Nicola Normanno, Maria Pergameno, Alessia Iannaccone & Antonella De Luca -- Selection of NSCLC patients to treat with EGFR inhibitors in the era of personalized medicine / Rafael Rosell, Laura Bonanno & Miquel Taron -- Clinical results with EGFR inhibitors in NSCLC and their use in the treatment of metastatic disease / Cesare Gridelli & Antonio Rossi -- Clinical results with EGFR inhibitors in colorectal cancer / Erika Martinelli, Teresa Troiani, Floriana Morgillo & Fortunato Ciardiello -- EGFR-directed therapies in squamous cell carcinoma of the head and neck / Pol Specenier & Jan B. Vermorken -- Optimal use of EGFR inhibitors : challenges, new drugs and future directions / Sara De Dosso, Rodrigo Dienstmann & Josep Tabernero.
  • The debate over eHealth is alive as never before. Supporters suggest that it will result in dramatic innovations in healthcare, including a giant leap towards patient-centered care, new opportunities to improve effectiveness, and enhanced wellness and quality of life. In addition, the growing market value of investments in health IT suggests that eHealth can offer at least a partial cure for the current economic stagnation. Detractors counter these arguments by claiming that eHealth has already failed: the UK Department of Health has shut down the NHS National Program for IT, Google has discontinued its Health flagship, and doubts have arisen over privacy safeguards for both patients and medical professionals. This book briefly explains why caregivers, professionals, technicians, patients, politicians, and others should all consider themselves stakeholders in eHealth. It offers myth-busting responses to some ill-considered arguments from both sides of the trench, in the process allowing a fresh look at eHealth. In addition, it describes how the technical failures of previous eHealth systems can be avoided, examines the legal basis of eHealth, and discusses associated ethical issues.
  • An overview of healthcare disparities -- Provider factors in healthcare disparities -- Patient factors in healthcare disparities -- Healthcare system factors in healthcare disparities -- The social "nonmedical" determinants of health -- The role of the Internet in American life -- The iHealth revolution -- Digital disparities -- The role of eHealth in patient engagement and quality improvement -- Medical informatics -- Public health informatics -- Beyond traditional paradigms in disparities research -- Health information technology policy perspectives and healthcare disparities -- Disparities and eHealth: achieving the promise and the potential.
  • Eiger is the sole TNF family member found in Drosophila melanogaster. This signaling molecule is induced during infection and is required for an appropriate immune response to many microbes; however, little is known concerning where eiger is produced and what genes are regulated by eiger. Here we show that eiger is made in the fly's fat body during a Salmonella typhimurium infection. Using tissue specific knockdowns we found that eiger expression in the fat body is required for all of the phenotypes we observed in eiger null mutant flies. This includes reduced melanization, altered antimicrobial peptide expression and reduced feeding rates. The effect of eiger on feeding rates alone may account for the entire phenotype seen in eiger mutants infected with S. typhimurium. We further characterized the eiger response using transcriptional arrays. We found that the eiger regulates a number of genes involved in metabolism and hormonal signaling during an immune response. How these genes are involved in the immune response is not clear. Finally we examined the role of age related decline of the immune system in D. melanogaster during bacterial infection. We found that vigor and tolerance are reduced when old flies are challenged with a variety of bacterial pathogens.
  • Also available: Print – 1908-
    T. 1. Einführung in das Wesen der Magen-, Darm- und Stoffwechsel-Krankheiten.
  • Print Material
  • Also available: Print – 2009
  • Elbow arthroscopy 2013
    Anatomy and Portals -- Arthroscopic Technique -- Osteochondritis Dissecans Lesions and Loose Bodies of the Elbow -- Arthroscopic Treatment of Lateral Epicondylitis -- Elbow Arthroscopy in Stiff Elbow -- The Role of Arthroscopy in Elbow Instability -- Endoscopy Around the Elbow -- Arthroscopic Treatment of Elbow Fractures -- Elbow Arthroscopy Complications -- Elbow Arthroscopy: The Future.
  • Part I. Exposures -- part II. Fractures and trauma -- part III. Complications of trauma -- part IV. Soft tissue injuries and management -- part V. Nonreplacement and reconstructive surgery -- part VI. Joint replacement arthroplasty -- part VII. Postoperative management.
  • Clinically Relevant Elbow Anatomy and Surgical Approaches -- Ulnar Collateral Ligament: Throwing Biomechanics -- Valgus Extension Overload -- Ulnohumeral Chondral and Ligamentous Overload -- Epidemiology of Elbow Ulnar Collateral Ligament Injuries -- History and Physical Exam on the Thrower{u2019}s Elbow -- Radiographic Imaging of the Elbow -- MR Imaging in Patients with Ulnar Collateral Ligament Injury -- Ultrasound Imaging of Ulnar Collateral Ligament Injury -- The Conservative Treatment of Ulnar Collateral Ligament Injuries -- Injections Including Platelet Rich Plasma -- Ulnar Collateral Ligament Reconstruction: Graft Selection and Harvest Technique -- Primary Repair of Ulnar Collateral Ligament Injuries of the Elbow -- The Role of Arthroscopy in Athletes with Ulnar Collateral Ligament Injuries -- Biomechanics of Reconstruction Constructs -- Figure of 8 Technique and Outcomes -- Ulnar Collateral Ligament Reconstruction: Docking Technique -- American Sports Medicine Institute Techniques and Outcomes -- Ulnar Collateral Ligament Reconstruction: Alternative Surgical Techniques -- Combined Flexor-Pronator Mass and Ulnar Collateral Ligament Injuries -- Ulnar Nerve Issues in Throwing Athletes -- Revision Ulnar Collateral Ligament Reconstruction -- Ulnar Collateral Ligament Injuries in High School-Aged Athletes -- Ulnar Collateral Ligament Injury in Female Athletes -- Complications of Ulnar Collateral Ligament Repair -- Sports Specific Outcomes for Ulnar Collateral Ligament Reconstruction -- Rehabilitation of the Overhead Athlete{u2019}s Elbow -- Sport Specific Rehabilitation after Ulnar Collateral Ligament Surgery.
  • Electric Cell-Substrate Impedance Sensing Concept to Commercialization / Ivar Giaever and Charles R. Keese -- Protein Kinase C Isoforms in the Formation of Focal Adhesion Complexes: Investigated by Cell Impedance / Havovi Chichger, Katie L. Grinnell and Elizabeth O. Harrington -- ECIS as a Tool in the Study of Metastasis Suppressor Genes: Epithelial Protein Lost In Neoplasm (EPLIN) / Andrew J. Sanders, Vladimir M. Saravolac, Malcolm D. Mason and Wen G. Jiang -- Electrical Cell-Substrate Impedance Sensing for Measuring Cellular Transformation, Migration, Invasion, and Anticancer Compound Screening / Bryan Plunger, Chang Kyoung Choi and Tim E. Sparer -- Epithelial-Mesenchymal Transition and the Use of ECIS / Jane Lane and Wen G. Jiang -- Cell Growth and Cell Death Studied by Electric Cell-Substrate Impedance Sensing / Judith Anthea Stolwijk, Stefanie Michaelis and Joachim Wegener -- Tight Junctions in Cancer Metastasis and Their Investigation Using ECIS (Electric Cell-Substrate Impedance Sensing) / Tracey A. Martin and Wen G. Jiang -- Epithelial Wound Healing and the Effects of Cytokines Investigated by ECIS: Electric Cell-Substrate Impedance Sensing in Epithelial Research / Katalin Szaszi, Matthew Vandermeer and Yasaman Amoozadeh -- Tumour-Endothelial and Tumour-Mesothelial Interactions Investigated by Impedance Sensing Based Cell Analyses / Wen G. Jiang, Lin Ye, Haiying Ren, Ann Kift-Morgan and Nicholas Topley, et al. -- Application of Electric Cell-Substrate Impedance Sensing in Evaluation of Traditional Medicine on the Cellular Functions of Gastric and Colorectal Cancer Cells / Lin Ye, Ke Ji, Jiafu Ji, Rachel Hargest and Wen G. Jiang -- Electric Cell-Substrate Impedance Sensing as a Screening Tool for Wound Healing Agents / Cheuk Lun Liu, Jacqueline Chor Wing Tam, Andrew J. Sanders, David G. Jiang and Chun Hay Ko, et al. -- ECIS, Cellular Adhesion and Migration in Keratinocytes / David C. Bosanquet, Keith G. Harding and Wen G. Jiang -- Current and Future Applications of ECIS Models to Study Bone Metastasis / Lin Ye, Sivan M. Bokobza, Howard G. Kynaston and Wen G. Jiang.
  • The past two decades have witnessed an explosion of knowledge and radical changes in our understanding of the molecular, ionic, genetic, and pharmacologic basis of electrical diseases of the heart. Electrical diseases of the heart are heritable arrhythmogenic clinical entities that may share common clinical and genetic features, yet may be distinctly different in their genesis, prognosis, and management. Notably, both congenital and acquired electrical diseases of the heart are receiving increased recognition as a result of important advances in genetic analysis. In this second edition of Electrical Diseases of the Heart, the Editors' goal has been to embrace and highlight the explosion of knowledge that our field has witnessed since the publication of the first edition. The approach continues to be one of bridging basic and clinical science in an attempt to advance meaningfully our understanding of heart disease and identify the knowledge gaps that exist. This volume covers the basic foundations and primary electrical diseases and with the companion volume provides the latest developments in the field of experimental and clinical cardiac electrophysiology, genetics, pharmacology and interventional therapies of various clinical arrhythmogenic entities. Residents, fellows and physicians in cardiology and electrophysiology will gain valuable insight into the latest developments in the field of cardiac electrophysiology and clinical electrocardiology by reading this book, including expert review of the genetic and epidemiologic considerations, diagnostic and therapeutic modalities of the newly discovered clinical syndromes and electrocardiographic phenomena, and their correlation with the most recent advances in the basic science.
  • Part I. Secondary Hereditary and Acquired Cardiac Channelopathies and Sudden Cardiac Death. Introduction to Part Three: Cardiac Remodeling / N. A. Mark Estes III -- Arrhythmias and Arrhythmia Management in Hypertrophic Cardiomyopathy / J. Martijn Bos, Steve R. Ommen, Michael J. Ackerman -- Sudden Cardiac Death in Dilated Cardiomyopathy and Skeletal Muscular Dystrophy / Ingrid A. W. van Rijsingen, Anneke J. van der Kooi, Yigal M. Pinto -- Arrhythmogenic Right Ventricular Cardiomyopathy/Dysplasia / Hugh Calkins, Frank Marcus -- The Wolff-Parkinson-White Syndrome and the Risk of Sudden Death / Michael H. Gollob ... [et al.] -- Acquired (Drug-Induced) Long and Short QT Syndromes / Rashmi R. Shah, Ihor Gussak -- Acquired Form of Brugada Syndrome / Wataru Shimizu -- Part II. Clinical Rhythmology: Diagnostic Methods and Tools. Introduction to Part IV: Abnormal Electrical Functions of the Heart and Their Diagnoses in Clinic / Benjamin C. Eloff -- Diagnostic Electrocardiography / Preben Bjerregaard -- Microvolt T Wave Alternans: Mechanisms and Implications for Prediction of Sudden Cardiac Death / Florian Rader, Lance D. Wilson, Ottorino Costantini -- Heart Rate Variability: Measurements and Risk Stratification / Yi Gang -- Orthostatic Challenge Tests: Active Standing and Head-Up Tilt / Louise R. A. Olde Nordkamp, Nynke van Dijk, Wouter Wieling -- Signal Averaged ECG / Gioia Turitto ... [et al.] -- Surface Mapping and Magneto-Electrocardiography / Satsuki Yamada, Akihiko Kandori -- Ambulatory Monitoring: (Holter, Event Recorders, External, and Implantable Loop Recorders and Wireless Technology) / Rajesh N. Subbiah, Pow-Li Chia, Peter Leong-Sit -- Device Therapy for Remote Patient Management / Dwight W. Reynolds, Christina M. Murray, Robin Germany -- Invasive Electrophysiologic Testing: Role in Sudden Death Prediction / Jan Němec, Win-Kuang Shen -- Provocative (Drug) Testing in Inherited Arrhythmias / Wataru Shimizu, Michael J. Ackerman -- Novel Predictors of Sudden Cardiac Death / Sumeet S. Chugh, Rasmus Havmöller, Carmen Teodorescu -- Genetic Testing / David J. Tester, Michael J. Ackerman -- Part III. Risk Stratification of Sudden Cardiac Death in Acquired Clinical Conditions. Introduction to Part Five: Screening for Risk of Sudden Cardiac Death / John B. Kostis -- Risk Stratification for Sudden Death in Patients with Coronary Artery Disease / Emerson H. Liu, Lilian P. Joventino, Alfred E. Buxton -- Sudden Death in Athletes / Domenico Corrado, Anna Baritussio, Mariachiara Siciliano -- Cardiac Channelopathies and Sudden Infant Death Syndrome / Peter J. Schwartz, Marco Stramba-Badiale, John R. Giudicessi -- Heart Failure and Sudden Death / Yong-Mei Cha, Win-Kuang Shen -- Neurologic Conditions and Sudden Death / David M. Ficker, Elson L. So -- Sudden Cardiac Death and Alcohol / Vincent M. Figueredo, Bhaskar Purushottam -- Sudden Cardiac Death and Addictive Chemical Substances / Bhaskar Purushottam, Vincent M. Figueredo -- Obstructive Sleep Apnea and Sudden Death / Apoor S. Gami, Virend K. Somers -- Sudden Cardiac Arrest in Chronic Kidney Disease / Rod Passman, Mai Ots-Rosenberg, Ihor Gussak -- Clinical Trials in Sudden Cardiac Death Prevention: Principles and Endpoints / Andrzej S. Kosinski -- Part IV. Treatment and Prevention Modalities. Introduction to Part IV: Treatment Modalities / Mark E. Josephson -- Clinical Role of Antiarrhythmic Drugs in the Prevention of Sudden Death / Hon-Chi Lee, Kristin T. L. Huang -- Non-antiarrhythmic Drugs in Sudden Death Prevention / Leonard Ilkhanoff, Alan H. Kadish, Jason T. Jacobson -- Non-surgical Treatment and Prevention of Atrial Fibrillation / Patricia Tung, Peter J. Zimetbaum -- Surgical Treatment of Atrial Fibrillation / John M. Stulak, Hartzell V. Schaff -- Catheter Ablation for Triggered Ventricular Fibrillation and Polymorphic Ventricular Tachycardia / Frédéric Sacher ... [et al.] -- Catheter Ablation for Scar-Dependent Ventricular Tachycardia / Roy M. John, William G. Stevenson -- The Implantable Cardioverter Defibrillator: Technical and Clinical Considerations / Bruce L. Wilkoff, Sergio G. Thal -- Beyond Sudden Death Prevention: Minimizing ICD Shocks and Morbidity, and Optimizing Efficacy / Eyal Nof ... [et al.] -- Pacing and Cardiac Resynchronization / Robert F. Rea.
  • "This book will enable the reader to gain a sound understanding of contemporary and futuristic evidence-based interventions and assessment procedures for pelvic floor disorders. It gathers the experiences of some of the most important experts on electrical stimulation techniques, offering a multidisciplinary and problem-oriented approach organized according to therapeutic goals. Interventions are recommended that are consistent with theory and display clinical efficacy for specific disorders, including urinary incontinence or retention, fecal incontinence, constipation, pelvic pain, sexual dysfunction, and neurological diseases involving the pelvic floor. All of the surgical or rehabilitative techniques requiring electrical stimulation for the treatment of these disorders are explored, and essential background information is provided on functional anatomy, neurophysiology, and concepts in electrotherapy. This volume will be a very useful tool for urologists, general or colorectal surgeons, gynecologists, and anesthesiologists, and also physiotherapists and alternative medicine practitioners (a specific chapter focuses on electroacupuncture). It will assist in their clinical practice as they seek to help the very many patients who suffer from any of the wide range of functional pelvic floor disorders"--Publisher's description.
  • Also available: Print – 2001
  • Print Material
  • Important concepts -- Sinus node dysfunction -- Atrioventricular conduction abnormalities -- Junctional tachycardia -- Atrioventricular nodal reentrant tachycardia (AVNRT) -- Atrioventricular reentrant tachycardias : concealed -- Accessory pathways and Wolff-Parkinson-White (WPW) -- Syndrome and variants -- Atrial tachycardias -- Atrial flutter -- Atrial fibrillation -- Wide complex tachycardia (supraventricular with abberancy -- Vs.ventricular tachycardia) -- Ventricular tachycardia (VT) in structural heart disease -- Ventricular tachycardia in patients with normal hearts -- Polymorphic VT and ventricular fibrillation (VF).
  • Electrocardiography of Laboratory Animals is the only book covering electrocardiography of laboratory animals, including dogs, mini-pigs, and cynomologus monkeys. As more countries institute requirements for the care of laboratory animals in research, this publication offers an effective standard on performing and analyzing ECGs. Topics covered include safety electrocardiography, toxicology, safety pharmacology, and telemetry. Electrocardiography of Laboratory Animals will assist biological and medical researchers, veterinarians, zoologists, and students in understanding electrocardiography of various species of animals used in research. Covers safety electrocardiography of large laboratory animals. Offers comprehensive analysis of ECGs for practical laboratory use. Includes a self-evaluation section for testing of ECG reading and analysis.
  • An introduction to electrochemical methods in neuroscience / Laura M. Borland and Adrian C. Michael -- Rapid dopamine release in freely moving rats / Donita L. Robinson and R. Mark Wightman -- Presynaptic regulation of extracellular dopamine as studied by continuous amperometry in anesthetized animals / Marianne Benoit-Marand, Marie-Francoise Suaud-Chagny, and François Gonon -- Fast scan cyclic voltammetry of dopamine and serotonin in mouse brain slices / Carrie E. John and Sara R. Jones -- High-speed chronoamperometry to study kinetics and mechanisms for serotonin clearance in vivo / Lynette C. Daws and Glenn M. Toney -- Using high-speed chronoamperometry coupled with local dopamine application to assess dopamine transporter function / Joshua M. Gulley, Gaynor A. Larson, and Nancy R. Zahniser -- Determining serotonin and dopamine uptake rates in synaptosomes using high-speed chronoamperometry / Xiomara A. Perez, Amanda J. Bressler, and Anne Milasincic Andrews -- Using fast-scan cyclic voltammetry to investigate somatodendritic dopamine release / Sarah Threlfell and Stephanie J. Cragg -- From interferant anion to neuromodulator : ascorbate oxidizes its way to respectability / George V. Rebec -- Biophysical properties of brain extracellular space explored with ion-selective microelectrodes, integrative optical imaging and related techniques / Sabina Hrabetová and Charles Nicholson -- Hydrogen peroxide as a diffusible messenger : evidence from voltammetric studies of dopamine release in brain slices / Margaret E. Rice, Marat V. Avshalumov, and Jyoti C. Patel -- In vivo voltammetry with telemetry / Paul A. Garris ... [et al.] -- Oxidative stress at the single cell level / Christian Amatore and Stephane Arbault -- Electrochemistry at the cell membrane/solution interface / Nathan Wittenberg ... [et al.] -- The patch amperometry technique : design of a method to study exocytosis of single vesicles / Gregor Dernick, Guillermo Alvarez de Toledo, and Manfred Lindau -- Amperometric detection of dopamine exocytosis from synaptic terminals / Roland G.W. Staal, Stephen Rayport, and David Sulzer -- Scanning electrochemical microscopy as a tool in neuroscience / Albert Schulte and Wolfgang Schuhmann -- Principles, development and applications of self-referencing electrochemical microelectrodes to the determination of fluxes at cell membranes / Peter J.S. Smith, Richard H. Sanger, and Mark A. Messerli -- Second-by-second measures of L-glutamate and other neurotransmitters using enzyme-based microelectrode arrays / Kevin N. Hascup ... [et al.] -- Telemetry for biosensor systems / David A. Johnson and George S. Wilson -- The principles, development and application of microelectrodes for the in vivo determination of nitric oxide / Michael J. Serpe and Xueji Zhang -- In vivo fast-scan cyclic voltammetry of dopamine near microdialysis probes / Hua Yang and Adrian C. Michael.
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  • 1. Principles and methods. Full-field electroretinograms -- Focal macular ERGs -- Multifocal ERGs -- Electrooculography -- Optical coherence tomography -- 2. Hereditary retinal and allied diseases. Retinitis pigmentosa -- Crystalline retinopathy (Bietti) -- Batten disease -- Kearns-Sayre syndrome -- Choroideremia -- Gyrate atrophy -- Enhanced s-cone syndrome -- X-linked retinoschisis -- Nettleship-falls x-linked ocular albinism -- Complete and incomplete types of CSNB -- Fundus albipunctatus -- Oguchi's disease -- Cone dystrophy -- Rod monochromacy -- Blue cone monochromacy -- Congenital tritanopia - differential diagnosis of dominantly inherited juvenile optic atrophy -- Rod-cone dysfunction syndrome with an unusual form of ERG -- Association of negative ERG with diseases of unknown etiology -- Occult macular dystrophy -- Stargardt's disease (fundus flavimaculatus) -- Best's disease -- 3. Acquired retinal diseases. Diabetic retinopathy -- Retinal circulatory disturbances -- Retinal and choroidal detachment -- Inflammatory diseases of retina and choroid -- 4. Acquired macular diseases. Central serous chorioretinopathy -- Aphakic or pseudophakic cystoid macular edema -- Idiopathic epimacular membranes -- Foveal thickness and focal macular ERG -- Idiopathic macular hole -- Macular pseudohole -- Age-related macular degeneration.
  • Also available: Print – 2005
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  • 2013 ClinicalKey
    Approach to Nerve Conduction Studies and Electromyography -- Anatomy and Neurophysiology -- Basic Nerve Conduction Studies -- Late Responses -- Blink Reflex -- Repetitive Nerve Stimulation -- Anomalous Innervations -- Artifacts and Technical Factors -- Basic Statistics for Electrodiagnostic Studies -- Routine Upper Extremity, Facial, and Phrenic Nerve Conduction Techniques -- Routine Lower Extremity Nerve Conduction Techniques -- Basic Overview of Electromyography -- Anatomy for Needle Electromyography -- Basic Electromyography: Analysis of Spontaneous Activity -- Basic Electromyography: Analysis of Motor Unit Action Potentials -- Clinical-Electrophysiologic Correlations: Overview and Common Patterns -- Median Neuropathy at the Wrist -- Proximal Median Neuropathy -- Ulnar Neuropathy at the Elbow -- Radial Neuropathy -- Peroneal Neuropathy -- Femoral Neuropathy -- Tarsal Tunnel Syndrome -- Facial and Trigeminal Neuropathy -- Polyneuropathy -- Amyotrophic Lateral Sclerosis and its Variants -- Atypical Motor Neuron Disorders -- Radiculopathy -- Brachial Plexopathy -- Proximal Neuropathies of the Shoulder and Arm -- Lumbosacral Plexopathy -- Sciatic Neuropathy -- Neuromuscular Junction Disorders -- Myopathy -- Myotonic Muscle Disorders and Periodic Paralysis Syndromes -- Approach to Electrodiagnostic Studies in the Intensive Care Unit -- Approach to Pediatric Electromyography -- Basics of Electricity and Electronics for Electrodiagnostic Studies -- Electrical Safety and Iatrogenic Complications of Electrodiagnostic Studies.
  • Also available: Print – 2007
    The scope of the EMG examination -- Routine clinical electromyography -- Specialized electrodiagnostic studies -- Electrodiagnostic findings in neuromuscular disorders.
  • Introduction to electron crystallography / Werner Kuhlbrandt -- Practical aspects in expression and purification of membrane proteins for structural analysis / Kutti R. Vinothkumar, Patricia C. Edwards, and Joerg Standfuss -- Two-dimensional crystallization of membrane proteins by reconstitution through dialysis / Matthew C. Johnson [and others] -- Monolayer two-dimensional crystallization of membrane proteins / Luc Lebeau and Catherine Venien-Bryan -- Screening for two-dimensional crystals by transmission electron microscopy of negatively stained samples / Tina M. Dreaden [and others] -- Low dose techniques and cryo-electron microscopy / Yoshinori Fujiyoshi -- Grid preparation for cryo-electron microscopy / Nobuhiko Gyobu -- Recording high-resolution images of two-dimensional crystals of membrane proteins / Agustin Avila-Sakar [and others] -- Collection of high-resolution electron diffraction data / Tamir Gonen -- Image processing of 2D crystal images / Marcel Arheit [and others] -- Merging of image data in electron crystallography / Marcel Arheit [and others] -- Evaluation of electron crystallographic data from images of two-dimensional crystals / Vinzenz M. Unger -- Modeling, docking, and fitting of atomic structures to 3D maps from cryo-electron microscopy / Gregory S. Allen and David L. Stokes -- Phasing electron diffraction data by molecular replacement : strategy for structure determination and refinement / Goragot Wisedchaisri and Tamir Gonen -- High-throughput methods for electron crystallography / David L. Stokes [and others] -- Automated grid handling and image acquisition for two-dimensional crystal screening / Anchi Cheng -- Automation of data acquisition in electron crystallography / Anchi Cheng -- Automation of image processing in electron crystallography / Marcel Arheit [and others] -- Choice and maintenance of equipment for electron crystallography / Deryck J. Mills and Janet Vonck -- Future developments in instrumentation for electron crystallography / Kenneth H. Downing -- Tubular crystals and helical arrays : structural determination of HIV-1 capsid assemblies using iterative helical real-space reconstruction / Peijun Zhang, Xin Meng, and Gongpu Zhao -- Single particle electron microscopy / Wilson C.Y. Lau and John L. Rubinstein -- Electron tomography of paracrystalline 2D arrays / Hanspeter Winkler, Shenping Wu, and Kenneth A. Taylor -- High-resolution imaging of 2D outer membrane protein F crystals by atomic force microscopy / Dimitrios Fotiadis and Daniel J. Muller -- Determination of soluble and membrane protein structures by x-ray crystallography / Raquel L. Lieberman, Mary E. Peek, and J. Derrick Watkins -- Solution nuclear magnetic resonance spectroscopy / James J. Chou and Remy Sounier -- Structure-function insights of membrane and soluble proteins revealed by electron crystallography / Tina M. Dreaden [and others] -- Lipid monolayer and sparse matrix screening for growing two-dimensional crystals for electron crystallography : methods and examples / Mark Yeager, Kelly A. Dryden, and Barbie K. Ganser-Pornillos -- Processing of electron diffraction patterns with the XDP program / Kaoru Mitsuoka -- Future directions of electron crystallography / Yoshinori Fujiyoshi.
  • Conventional specimen preparation techniques for transmission electron microscopy of cultured cells / John J. Bozzola -- Processing biological tissues for ultrastructural study / José A. Mascorro and John J. Bozzola -- Processing plant tissues for ultrastructural study / John Kuo and Ivan Kuo -- Microwave-assisted processing and embedding for transmission electron microscopy / Paul Webster -- Ultramicrotomy for biological electron microscopy / Herbert K. Hagler -- Poststaining grids for transmission electron microscopy : conventional and alternative protocols / E. Ann Ellis -- Negative staining of thinly spread biological samples / J. Robin Harris -- Recent advances in high-pressure freezing : equipment- and specimen-loading methods / Kent L. McDonald ... [et al.] -- Cryo-ultramicrotomy : cryo-electron microscopy of vitreous sections / Dimitri Vanhecke, Luca Studer, and Daniel Studer -- Cell-free extract systems and the cytoskeleton : preparation of biochemical experiments for transmission electron microscopy / Margaret Coughlin, William M. Brieher, and Ryoma Ohi -- Electron microscopy/in situ hybridization tracking of DNA and RNA sequences at high resolution / Dusan Cmarko and Karel Koberna -- Correlative light and electron microscopy using immunolabeled resin sections / Heinz Schwarz and Bruno M. Humbel -- Cryosectioning fixed and cryoprotected biological material for immunocytochemistry / Paul Webster and Alexandre Webster -- F-TEM images : integrating fluorescence microscopy with transmission electron microscopy / Paul A. Sims and Jeff D. Hardin -- Quantitative immunoelectron microscopy : alternative ways of assessing subcellular patterns of gold labelling / Terry M. Mayhew -- Electron crystallography of membrane proteins / Hui-Ting Chou, James Evans, and Henning Stahlberg -- Cryo-electron microscopy of icosahedral virus particle / Wen Jiang and Wah Chiu -- 3D reconstructions of chromosomes with electron tomography / Peter Engelhardt -- Whole-mount immuno-electron tomography of chromosomes and cells / Peter Engelhardt ... [et al.] -- 3D cryo-transmission electron microscopy of cells and organelles / Michael Marko and Chyong-Ere Hsieh -- Electron energy-loss spectroscopy (EELS) as a tool for elemental analysis in biological specimens / Nadine Kapp ... [et al.] -- Conventional specimen preparation techniques for scanning electron microscopy of biological specimens / John J. Bozzola -- Variable pressure and environmental scanning electron microscopy : imaging of biological samples / Brendan J. Griffin -- Cryoplaning technique for visualizing the distribution of water in woody tissue by cryo-scanning electron microscopy / Yasuhiro Utsumi and Yuzou Sano -- X-ray microanalysis in the scanning electron microscope / Godfrield M. Roomans and Anca Dragomir -- Botanical SEM X-ray microanalysis in cryo-scanning electron microscopy / Beat Frey -- Static secondary ion mass spectrometry for biological and biomedical research / Nicholas P. Lockyer -- Using secondary ion mass spectrometry and multi-isotope imaging mass spectrometry in biological materials : application to higher plants / Nicole Grignon.
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  • Chapter 1. Electron Microscopy of Viruses -- Chapter 2. Bacterial TEM : New Insights from Cryo-Microscopy -- Chapter 3. Analysis of the Ultrastructure of Archaea by Electron Microscopy -- Chapter 4. Chlamydomonas : Cryopreparation Methods for the 3-D Analysis of Cellular Organelles -- Chapter 5. Ultrastructure of the Asexual Blood Stages of Plasmodium falciparum -- Chapter 6. Electron Tomography and Immuno-labeling of Tetrahymena thermophila Basal Bodies -- Chapter 7. Electron Microscopy of Paramecium (Ciliata).
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  • The Human Genome Project was accomplished by a reduction in the cost of DNA sequencing by three orders of magnitude. Further cost reductions are required for sequencing to become a standard tool in clinical medicine and to enable personalized medicine via individual genome sequencing. The current cost varies between $50k to $100k over a period of months; depend on the technology, accuracy and read-length. It is desired to reduce the cost to $1000 per genome to enable profiling of individuals genome. To achieve this goal, a highly integrated platform with simplified chemistry is required. In this dissertation, we introduce a novel method for DNA sequencing based on electrical detection of polymerization reaction, called "Thermo/pH sequencing". Our proposed method is based on the direct measurement of the heat release or the pH modulation (change of H+ ion concentration in the solution) during DNA extension. For high throughput DNA sequencing, DNA strands are immobilized to small micron-size beads in a microfluidic platform. The DNA-beads are in a reaction mixture in contact with an array of sensitive micro-machined heat or pH sensors, which detect the electrical signature from incorporation of a complementary base (dNTP) in the presence of appropriate reagents (DNA polymerase, and polymerase reaction buffer). This results to a label-free, long-read and fast chemistry; 10x reduction in reagent cost with 10x increase in throughput can potentially yield to significant improvement in the cost of genome sequencing to less than $1000. In addition, substituting optical detection set-up with microelectronic sensor reduces the capital cost of sequencing instruments from $500k to less than $50k. We demonstrate the proof of concept for this technology at large scale. Then we describe the development of an appropriate microfluidic platform and two micromachined electrical biosensors that employ electrical detection for heat or pH detection. Both versatile platforms can be multiplexed and have the potential of providing rapid and inexpensive measurements without any compromise in the sensitivity, making them good potential candidates for use in the clinical setting. We report a chip-based integrated differential microfluidic nanocalimeters with on-chip injection and multiplexing unit, capable of characterizing the heat of reaction with unprecedented 2-nW resolution in 1 Hz bandwidth for nanoliter scale samples. We successfully demonstrate DNA Thermosequencing with sequential injection of different nucleotides into the integrated microfluidic calorimeter device. In addition, the device can serve as a powerful tool to characterize a variety of the biomedical processes, such as metabolic activities of microorganisms, living cells and catalyzed reactions. We also present a microfabricated device in microfluidics for pH sequencing, called nanoneedle biosensor. The key element for this device is a 10nm wide gap on the end of the needle of total diameter about 100nm. Any change in the population of molecules in this gap results in a change of impedance across the gap; single molecule detection should be possible. In addition, DNA-beads can be allocated iv near the sensors to measure the pH change during DNA extension. The design, fabrication, testing, optimization and a modified structure of the device for higher signal to noise ratio are presented. Toward an integrated sequencer platform, automation and reduced labor cost, higher throughput, accuracy and efficiency for genomics and proteomics analysis; further integration and optimization of the presented systems are required. We envision the integration of our CMOS-compatible devices with a CMOS integrated circuitry into a high throughput gene sequencer or proteomics system. The proteomics system enables multiplex analysis using an array of micro-channels for probing clinically relevant samples such as the human serum for various protein and nucleic acid biomarkers for cancer detection, and also the detection of pathogenic bacteria in solution.
  • "This book introduces readers to structured systems analysis and the medications domains. It starts off with top-down decomposition of workflows and data. It applies structured systems analysis methodology and tools to electronic prescription, computerized physician order entry, drug dispensation, medication administration, and clinical decision support. Providing a comprehensive view of the EHR/EMR, the text covers user interface considerations, reporting requirements, and standards and vocabularies for meaningful use. Assuming no previous clinical and/or informatics knowledge, the author uses accessible language and includes over 250 figures and 100 review questions with answers"--Provided by publisher.
  • Part 1. Introduction -- part 2. Identifying and preventing EHR safety concerns -- part 3. EHR users and usability -- part 4. Clinical decision support -- part 5. Referrals -- part 6. Laboratory test result management -- part 7. Bar coded medication administration -- part 8. Computer-based provider order entry.
  • Introduction to e-Healthcare Information Security / Charles A. Shoniregun, Kudakwashe Dube and Fredrick Mtenzi -- Securing e-Healthcare Information / Charles A. Shoniregun, Kudakwashe Dube and Fredrick Mtenzi -- Laws and Standards for Secure e-Healthcare Information / Charles A. Shoniregun, Kudakwashe Dube and Fredrick Mtenzi -- Secure e-Healthcare Information Systems / Charles A. Shoniregun, Kudakwashe Dube and Fredrick Mtenzi -- Towards a Comprehensive Framework for Secure e-Healthcare Information / Charles A. Shoniregun, Kudakwashe Dube and Fredrick Mtenzi -- Towards a Unified Security Evaluation Framework for e-Healthcare Information Systems / Charles A. Shoniregun, Kudakwashe Dube and Fredrick Mtenzi -- Discussions / Charles A. Shoniregun, Kudakwashe Dube and Fredrick Mtenzi.
  • Also available: Print – 2012
    Chapter 1. Identifying general requirements -- Chapter 2. Identifying detailed requirements -- Chapter 3. Selecting a solution -- Chapter 4. Implementing an electronic recording and reporting system .
  • "The new edition of Electrophysiological Disorders of the Heart helps you diagnose and treat a full range of heart rhythm disorders using today's latest technologies and therapies. It provides practical, hands-on coverage of hot topics such as pediatric EP, imaging, echocardiography-guided EP procedures, regenerative therapies, cardiac pacing, and more. Now available in a new full-color format, the title also includes easy online access at "--Publisher's website.
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  • Field Potential Generation and Current Source Density Analysis / L. Stan Leung -- Current Source Density Analysis of Ongoing Neural Activity: Theory and Application / Yonghong Chen, Mukesh Dhamala, Anil Bollimunta, Charles E. Schroeder, Mingzhou Ding -- The Juxtacellular Recording-Labeling Technique / Didier Pinault -- Neural Recording Using Digital Telemetry / André A. Fenton, Kathryn J. Jeffery, James G. Donnett -- Large-Scale Neural Ensembles in Mice: Methods for Recording and Data Analysis / Hui Kuang, Joe Z. Tsien -- Behavioral Correlates of Neuronal Activity Recorded as Single-Units: Promises and Pitfalls as Illustrated by the Rodent Head Direction Cell Signal / Robert W. Stackman -- Event-Related Potentials of the Cerebral Cortex / Steven L. Bressler -- Multisite Spike-Field Coherence, Theta Rhythmicity, and Information Flow Within Papez's Circuit / Zimbul Albo, Gonzalo Viana Prisco, Robert P. Vertes -- Cognitively Relevant Recoding in Hippocampus: Beneficial Feedback of Ensemble Codes in a Closed Loop Paradigm / Robert E. Hampson, John D. Simeral, Theodore W. Berger, Dong Song, Rosa H. Chan, Vasilis Z. Marmarelis, Sam A. Deadwyler -- An Intact Septo-Hippocampal Preparation for Investigating the Mechanisms of Hippocampal Oscillation / Romain Goutagny, Jesse Jackson, Sylvain Williams -- Targeted Modulation of Neural Circuits: A New Treatment Strategy for Neuropsychiatric Disease / Helen S. Mayberg, Paul E. Holtzheimer.
  • Psychophysiology is an ever expanding field. The application of psychophysiological investigations to psychiatric disorders is likewise expanding and has in fact shed much light on some of the neural processes contributing to the development of psychiatric symptoms and/or their amelioration following treatment. The first part of this volume deals with a number of conditions where psychophysiological investigations have recently provided some insight into the pathophysiology of a particular manifestation (e.g., dissociation) or a disorder. Although this volume has a main focus on electrophysiological investigative modalities where neuroimaging was complimentary this added insight was included. The second part of the volume focuses on novel uses of psychophysiological measures, combining it with neuropsychology and imaging where possible, in the context of neuropsychiatric research and describes advanced analytical tools. Both basic and clinical investigators in this field should find the reviews and interpretations provided clear and informative. Clinicians will find this volume easy to assimilate. While direct clinical applications may be down the road, the insights provided should help the practicing clinicians to have firmer understanding of the complexity of the disorder they manage in everyday practice.
  • Pt. I. Basic concepts of DNA transfer via electroporation. Application of electroporation gene therapy: past, current, and future / Lluis M. Mir -- Mechanism by which electroporation mediates DNA migration and entry into cells and targeted tissues / Marie-Pierre Rols -- Applicator and electrode design for in vivo DNA delivery by electroporation / Dietmar Rabussay -- Electrode assemblies used for electroporation of cultured cells / Leda Raptis and Kevin L. Firth -- Formulations for DNA delivery via electroporation in vivo / Khursheed Anwer -- Overview of drug delivery and alternative methods to electroporation / Sek-Wen Hui -- Nanoelectroporation: a first look / Raji Sundararajan -- Pt. II. In vitro targeted gene delivery via electroporation. Nucleofection of human embryonic stem cells / Henrike Siemen ... [et al.] -- Delivery of whole tumor lysate into dendritic cells for cancer vaccination / Linda N. Liu ... [et al.] -- Delivery of tumor-antigen-encoding mRNA into dendritic cells for vaccination / Annelies Michiels ... [et al.] -- Delivery of DNA into natural killer cells for immunotherapy / Kathrin Schoenberg, Hans-Ingo Trompeter, and Markus Uhrberg -- Electroporation of adherent cells in situ for the study of signal transduction and gap junctional communication / Leda Raptis ... [et al.] -- Delivery of DNA into adipocytes within adipose tissue / James G. Granneman -- Pt. III. In vivo targeted gene delivery via electroporation. Delivery of DNA into muscle for treating systemic diseases: advantages and challenges / Capucine Trollet, Daniel Scherman, and Pascal Bigey -- Delivery of DNA into skeletal muscle in large animals / Patricia A. Brown, Amir S. Khan, and Ruxandra Draghia-Akli -- Delivery of DNA into skin via electroporation / Babu M. Medi and Jagdish Singh -- Electroporation-mediated gene delivery to the lungs / Rui Zhou, James E. Norton, and David A. Dean -- Delivery of DNA into bladder via electroporation / Masaki Yoshida ... [et al.] -- Analysis of gene function in the retina / Takahiko Matsuda and Constance L. Cepko -- Optical in vivo imaging of electrically mediated delivery of siRNA into muscle for gene function analysis / Muriel Golzio and Justin Teissie -- Electroporation of adult zebrafish / N. Madhusudhana Rao, K. Murali Rambabu, and S. Harinarayana Rao -- Pt. IV. Treatment of cancer via electroporation gene therapy. Flow electroporation with pulsed electric fields for purging tumor cells / Abie Craiu and David Scadden -- Delivery of DNA into tumors / Shulin Li -- Intraturmoral bieomycin and IL-12 electrochemogenetherapy for treating head and neck tumors in dogs / Jeffry Cutrera ... [et al.] -- Systemic IL-12 gene therapy for treating malignancy via intramuscular electroporation / Shiguo Zhu and Shulin Li -- Treatment of SCCVII tumors with systemic chemotherapy and interleukin-12 gene therapy combination / Marina Torrero and Shulin Li -- Electroporation for drug and gene delivery in the cliic: doctors go electric / Julie Gehl -- IL-2 plasmid electroporation: from preclinical studies in phase I clinical trial / Holly M. Horton, Peggy A. Lalor, and Alain P. Rolland -- Pt. V. Treatment of other diseases via electroporation gene therapy. Factor IX gene therapy for hemophilia / James G. Fewell -- KGF-1 for wound healing in animal models / Guy P. Marti ... [et al.] -- Hapatocyte growth factor gene therapy for hypertension / Kazuo Komamura ... [et al.] -- Electroporation of corrective nucleic acids (CNA) in vivo to promote gene correction in dstrophic muscle / Robert M.I. Kapsa, Sharon H.A. Wong, and Anita F. Quigley -- Gene delivery to dystrophic muscle / Kim E. Wells ... [et al.] -- Effect of electroporation on cardiac electrophysiology / Vadim V. Fedorov, Vladimir P. Nikolski, and Igor R. Efimov -- Muscle and fat mass modulation in different clinical models / Ruxandra Draghia-Akli and Amir S. Khan -- Pt. VI. Applications of electroporation for DNA vaccination. DNA vaccination for prostate cancer / Anna-Karin Roos, Alan King, and Pavel Pisa -- HER2/neu DNA vaccination for breast tumors / Arianna Smorlesi ... [et al.] -- Electroporation-mediated HBV DNA vaccination in primate models / Yong-Gang Zhao and Yuhong Xu -- Taking electroporation-based delivery of DNA vaccination into humans: a generic clinical protocol / Torunn Elisabeth Tjelle ... [et al.] -- Production of monoclonal antibody by DNA immunization with electroporation / Kaw Yan Chua, John D.A. Ramos, and Nge Cheong.
  • Electroreception 2005
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  • ch. 1. Introduction and preview -- ch. 2. Entropy, relative entropy, and mutual information -- ch. 3. Asymptotic equipartition property -- ch. 4. Entropy rates of a stochastic process -- ch. 5. Data compression -- ch. 6. Gambling and data compression -- ch. 7. Channel capacity -- ch. 8. Differential entropy -- ch. 9. Gaussian channel -- ch. 10. Rate distortion theory -- ch. 11. Information theory and statistics -- ch. 12. Maximum entropy -- ch. 13. Universal source coding -- ch. 14. Kolmogorov complexity -- ch. 15. Network information theory -- ch. 16. Information theory and portfolio theory -- ch. 17. Inequalities in information theory.
  • ch. 1. Introductory orientation -- ch. 2. The Conformation of informational macromolecules -- ch. 3. Information processing in cells -- ch. 4. Molecular evolution -- ch. 5. Manipulating biomolecules -- ch. 6. Genomics -- ch. 7. Biomembranes -- ch. 8. G-protein-coupled receptors -- ch. 9. Pumps -- ch. 10. Ligand-gated ion channels -- ch. 11. Voltage-gated channels -- ch. 12. Resting potentials and cable conduction -- ch. 13. Sensory transduction -- ch. 14. The Action potential -- ch. 15. The Neuron as a secretory cell -- ch. 16. Neurotransmitters and neuromodulators -- ch. 17. The Postsynaptic cell -- ch. 18. Developmental genetics of the brain -- ch. 19. Epigenetics of the brain -- ch. 20. Memory -- ch. 21. Some pathologies.
  • Rick's Big Adventure -- All My Trials -- Fish Ate My Cancer -- Smoker's Cough -- Conference With Counsel -- Coming Through -- Here's Henry -- Why Me? -- How Do They Know What I've Got? -- Doctors and Cancer: Firewall.
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  • I. Underlying causes of healthcare disparities -- 1. Historical perspectives on healthcare disparities : is the past prologue? / Richard Allen Williams -- 2. Epidemiology of racial and ethnic disparities in health and healthcare / George A. Mensah and Maleeka J. Glover -- 3. Cultural diversity in medicine and in healthcare delivery / Richard Allen Williams -- II. Current problems -- 4. Healthcare and the politics of race / M. Gregg Bloche -- 5. Barriers to eliminating disparities in clinical practice: lessons from the IOM report "Unequal Treatment" / Joseph R. Betancourt and Angela Maina -- 6. Second-class medicine: implications of evidence-based medicine for improving minority access to the correct pharmaceutical therapy / Randall W. Maxey and Richard Allen Williams -- 7. The diversity benefit: how does diversity among health professionals address public needs? / Brian D. Smedley -- III. Approaches to correcting the problems -- 8. Eliminating disparities in healthcare through quality improvement / Kevin Fiscella -- 9. Eliminating racial discrimination in healthcare: a call for state healthcare anti-discrimination law / Vernellia R. Randall -- 10. Quality of care and health disparities: the evolving role of government / Garth N. Graham -- 11. The role of communities in eliminating healthcare disparities: getting down to the grass roots / JudyAnn Bigby -- 12. The potential impact of performance incentive programs on racial disparities in healthcare / Alyna T. Chien -- IV. Examples of what works -- 13. Monitoring socioeconomic determinants for healthcare disparities: tools from the Public Health Disparities Geocoding Project / Nancy Krieger ... [et a.] -- 14. The Association of Black Cardiologists: a small-group success story / Richard Allen Williams -- 15. Breathe easy in Seattle: addressing asthma disparities through healthier housing / James W. Krieger ... [et al.] -- 16. Access Health Solutions: a minority physician network model that works / Kathy B. Jackson -- 17. Carolinas Association for Community Health Equity-CACHE: a community coalition to address health disparities in racial and ethnic minorities in Mecklenburg County North Carolina / Yele Aluko -- V. Concluding recommendations -- 18. Principles for eliminating racial and ethnic disparities in healthcare / John Z. Ayanian and Richard Allen Williams.
  • ELISA guidebook. 2nd ed. 2009
    Springer Protocols
  • A biographical sketch of Elisha Bartlett. Early life and education -- Medical education -- Life in Lowell -- The peripatetic professor -- Return to Rhode Island -- Philosophy of medicine in the nineteenth century. Early nineteenth century American medicine -- The Paris Clinical School -- Influence of the Paris Clinical School in America -- Elisha Bartlett's philosophy of medicine. An introductory lecture on the objects and nature of medical science -- An essay on the philosophy of medical science -- An inquiry into the degree of certainty of medicine, and into the nature and extent of its power over disease -- The philosophy of therapeutics -- Bartlett's other writings -- Elisha Bartlett / TEXTS.
  • A key resource for coaches, scientists and clinicians.
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    A certain sense of self -- Shedding encumbrances -- One of Gall's gals -- Revelations -- Opportunism -- Gold rush -- Entering the fray -- An interlocking system -- Dr. Jekyll or Mr. Hyde? -- Members of a guild -- Citizen scientist -- Political fallout -- "You have to think it's fun" -- Notes -- Bibliography.
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    pt. A. General medicine -- pt. B. Anatomy -- pt. C. Biology, genetics and biochemistry -- pt. D. Therapeutic substances.
  • Bonus Student Consult access - included with the text - allows readers to conveniently access the book's content online. This concise and user-friendly reference provides crucial knowledge for the early years of medical training, as well as for exam preparation.
  • This concise, high-yield title in the popular Integrated Review Series focuses on the core knowledge in genetics while linking that information to related concepts from other basic science disciplines. Case-based questions at the end of each chapter enable you to gauge your mastery of the material, and a color-coded format allows you to quickly find the specific guidance you need. This concise and user-friendly reference provides crucial guidance for the early years of medical training and USMLE preparation. Effectively review for problem-based courses with the help of text boxes that help you clearly see the clinical relevance of the material.
  • This concise, high-yield title in the popular Integrated Review Series focuses on the core knowledge in immunology and microbiology while linking that information to related concepts from other basic science disciplines. Case-based questions at the end of each chapter enable you to gauge your mastery of the material, and a color-coded format allows you to quickly find the specific guidance you need. This concise and user-friendly reference provides crucial guidance for the early years of medical training and USMLE preparation. Effectively review for problem-based courses with the help of text boxes that help you clearly see the clinical relevance of the material.
  • Pharmakokinetics -- Pharmacodynamics and signal transduction -- Toxicology -- Treatment of infectious diseases -- Cancer and immunopharmacology -- Autonomic nervous system -- Hematology -- Cardiovascular system -- Renal system -- Inflammatory disorders -- Gastrointestinal pharmacology -- Endocrine pharmacology -- Central nervous system.
  • Ewing's sarcoma is the second most common malignant bone cancer in children. The prominent defining feature of Ewing's sarcoma is a translocation event between a member of the FET family of RNA binding proteins and a member of the Ets transcription factor family. The majority of patients have a translocation event between the EWSR1 gene and the FLI1 gene. The EWS-FLI1 translocation was first discovered in 1992 and to date, the mechanism by which EWS-FLI1 induces the formation of Ewing's sarcomas remains unclear. Understanding the role of EWS-FLI1 in oncogenesis is critical for Ewing's sarcoma and would have broad implications for other cancers as well. Translocations involving members of the FET or Ets families are also found in leukemia, prostate cancer and other sarcomas. A primary goal of my graduate work has been to develop tools to express EWS-FLI1 in primary human cells as well as in genetically engineered mice to understand how EWS-FLI1 induces oncogenesis and determine the cell of origin in Ewing's sarcoma. As recent work suggested that Ewing's sarcomas arise from a mesenchymal stem/progenitor cell (MSC), we examined the effects of EWS-FLI1 expression in primary human MSCs. We isolated MSCs from pediatric patients at Lucile Packard Children's Hospital to establish human bone marrow derived MSC lines (which we call HBMs). Through a series of experiments, we learned that the precise expression levels of EWS-FLI1 were critical in determining the effect of this oncogene on primary cells. High expression of EWS-FLI1 was not tolerated in HBMs. In contrast, when expressed at lower levels, stable EWS-FLI1 expression was maintained in HBMs. To elucidate transcriptional targets of EWS-FLI1 in HBMs, we used next-generation sequencing (RNAseq) to identify genes dysregulated by EWS-FLI1. Using this approach we identified 170 targets that constitute an EWS-FLI1 expression signature, including novel target genes. Expression of a subset of these genes was dependent on EWS-FLI1 expression in Ewing's sarcoma cell lines, validating their regulation by EWS-FLI1. The majority of these target genes were required for growth in soft agar of Ewing's sarcoma cell lines and some also showed an effect on cell growth. Among these EWS-FLI1 target genes we focused on a novel long non-coding RNA, lnc277, which is induced and regulated by EWS-FLI1 in Ewing's sarcoma cell lines and in other human cell lines ectopically expressing EWS-FLI1. Expression of lnc277 is highly specific to Ewing's sarcoma and is required for cell growth and transformation by EWS-FLI1. To decipher a mechanism for how lnc277 functions in Ewing's sarcoma cells, we have used protein arrays to identify interacting proteins. Lnc277 appears to interact with several proteins involved in transcription, splicing, RNA stability and translation, including STAU1, HNRPK1 and several others. Additionally, we performed RNAseq analysis of lnc277 knock-down to identify specific genes whose expression is altered upon depletion of lnc277. To elucidate the cell of origin for Ewing's sarcoma and create a model that can be used to test novel strategies for treatment, we have genetically engineered mice to conditionally express the EWS-FLI1 translocation from the endogenous EWSR1 locus. We have generated mice that contain lox sites within both the EWSR1 locus and the FLI1 locus such that upon Cre recombinase expression, some cells will undergo a reciprocal recombination event, generating both the EWS-FLI1 and FLI1-EWS chromosomes. We have genomic DNA and mRNA confirmation that this recombination occurs in vitro and in vivo after expression of Cre recombinase. This is the first example to our knowledge of a mouse model that faithfully recapitulates a translocation mechanism in a solid tumor. The reciprocal translocation model relies on two chromosomes recombining with each other, an event that we have found to be highly rare with these two chromosomes in the mouse. Therefore, we focused our efforts on a second mouse model where the recombination event occurs much more efficiently, our EWS-FLI1-V5 mouse model. The EWS-FLI1-V5 mouse model expresses a V5-epitope tagged version of EWS-FLI1 also from the EWSR1 locus. To create this model, a FLI1 cDNA was introduced downstream of the EWSR1 gene on the same chromosome. The expression of Cre recombinase results in the formation of the translocation by splicing the N-terminal EWSR1 exons to a FLI1 cDNA containing the C-terminal exons. This model leads to expression of EWS-FLI1-V5 in the majority of cells where Cre is expressed. We have carried out in vitro studies expressing EWS-FLI1-V5 in mouse embryo fibroblasts (MEFs) and mouse MSCs. Whereas EWS-FLI1-V5 expression inhibits proliferation in MEFs, MSCs expressing EWS-FLI1-V5 continue to proliferate. We have demonstrated that several of the new target genes identified in the human system were also regulated by EWS-FLI1-V5 in mouse cells. We have crossed both our Ewing's sarcoma mouse models to four Cre strains that express Cre recombinase in mesenchymal tissues as well as one that expresses Cre recombinase in the neural crest lineage. Mice from the reciprocal translocation model failed to develop tumors, most likely because the translocation event was so rare either no cell recombined the EWSR1 and FLI1 loci or that EWS-FLI1 expression was not tolerated in the cells that did recombine the loci. The EWS-FLI1-V5 mice expressing EWS-FLI1 in the mesenchymal lineage using Dermo1-Cre, Col1[alpha]2-Cre, Prx1-Cre or Sox9-Cre died embryonically. Interestingly, we only obtained mice that could potentially be expressing EWS-FLI1-V5 in the neural crest lineage using P0-Cre, suggesting the expression of EWS-FLI1-V5 in these cells was not toxic or that other cells can compensate for loss of the cells expressing EWS-FLI1-V5. Whether these adult mice actually express EWS-FLI1-V5 in the tissues derived from the neural crest lineage and whether these mice are tumor prone are areas for future study. Through this thesis work, we have used a combined approach that leverages both human and mouse model systems to create an in vivo model of Ewing's sarcomagenesis. These models could be used to define the cell of origin for Ewing's sarcoma and gain an understanding of the genetic requirements for oncogenesis downstream of EWS-FLI1. Through our studies of pediatric human mesenchymal stem cells expressing EWS-FLI1 in Chapters 2 and 3, we have discovered a number of novel EWS-FLI1 target genes and identified a lncRNA that is highly specific to and required for EWS-FLI1 mediated oncogenesis. In Chapters 4 and 5, two novel transgenic mouse strains were generated to express the EWS-FLI1 gene fusion from the endogenous EWSR1 locus in a way that is physiologically relevant to Ewing's sarcoma. These tools should help define the effects of EWS-FLI1 expression in primary and cancer cells and hopefully result in new therapies to benefit children diagnosed with this disease.
  • The genome is under constant threat by DNA damage arising from endogenous and exogenous sources, and it is particularly susceptible to damage during DNA replication. Using a genome-wide siRNA screen to identify proteins necessary for genome maintenance in the presence of replication stress, we identified NEK8/NPHP9, a ciliary protein kinase associated with two renal ciliopathies in humans and mice, nephronophthisis (NPHP) and polycystic kidney disease (PKD). Renal ciliopathies are a leading cause of kidney failure, but their exact etiology is poorly understood. Recent findings have shown that several genes linked to the DNA damage signaling are mutated in patients with NPHP or NPHP-like diseases. However, whether loss of the DNA damage response (DDR) itself played a causal role in NPHP is not clear, and the underlying mechanism linking these genes to NPHP is not addressed. This thesis work provides new mechanistic insight into the functions of the NIMA-related kinase, NEK8, in suppressing DNA damage arising from replication stress, and for the first time connects the replication stress response to cystic kidney diseases and renal ciliopathies. Here we directly demonstrate that replication stress, caused by the DNA polymerase inhibitor aphidicolin, as well as NEK8 loss, affects renal cell architecture in a 3D-culture system. Moreover, NEK8 mutation leads to replication stress and DNA damage in the pre-cystic kidney. We further establish that NEK8 is a crucial effector of the replication stress response and that it functions as part of the ATR-dependent signaling pathway, regulating replication fork dynamics and fork stability through effects on CDK activity. We also show NEK8's role in the replication stress response is compromised by ciliopathy-causing mutations. Thus, our study strongly suggests that excessive replication stress or a defect in the ability of cells to respond to replication stress leads to chronic damage in renal epithelial cells and kidney failure in ciliopathies. The major contributions of this dissertation are: (1) We validated NEK8 as a high confidence hit from a previously described unbiased siRNA screen designed to uncover genes that help maintain genome stability during DNA replication stress. (2) Cells lacking NEK8 form spontaneous DNA double-strand breaks (DSBs) which further accumulate when replication forks stall. (3) NEK8 acts at the replication fork to regulate fork dynamics and replication origin firing, particularly under conditions of replication stress. (4) NEK8 functions in the ATR pathway, interacting with ATR and other components of the replication checkpoint, and it suppresses S-phase CDK activity during replication to prevent premature origin firing. (5) NEK8 mutations, which produce kinase-inactive protein or juvenile cystic kidneys (jck), abolish the interaction of NEK8 with ATR and fail to prevent DNA damage accumulation in NEK8-deficient cells. (6) Disruption of NEK8, as well as replication stress induced by aphidicolin, perturbs both ciliogenesis and spheroid structure in a 3D assay that models renal kidney architecture and NPHP. This study therefore provides the first direct evidence that replication stress contributes to renal ciliopathies and mechanistic insight into how it does so. Furthermore, it identifies a new critical component of the replication stress response: NEK8.
  • The ubiquitous parasite Toxoplasma gondii has developed an exquisite arsenal of effectors to support its intracellular lifestyle and its persistence within its diverse hosts. In order to survive and resist clearance, this obligate intracellular parasite must contend with the host immune response. Different strains of the parasite vary dramatically in their interaction with the immune system, and studying these strain differences has furthered our understanding of the spectrum of host-pathogen interactions and led to the identification of parasite effectors. The work described here dissects the interactions between different strains of the parasite and host macrophages: innate immune cells that paradoxically both serve as a niche for parasite replication and defend the host against parasite infection. Chapter 1 introduces Toxoplasma, the immune response to infection, and discusses the role of known parasite effectors. Experiments described in Chapter 2 identify a novel secreted parasite factor, GRA25, which modulates cytokine secretion in macrophages and controls parasite virulence in mice. In Chapter 3, high throughput methods are used to characterize the transcriptional and phosphorylation landscape of macrophages infected with different Toxoplasma strains. These analyses demonstrate that a secreted polymorphic tyrosine kinase, ROP16, directs murine macrophage polarization towards an alternatively activated phenotype. They also reveal that Toxoplasma parasites activate the Type I interferon response, a response classically associated with cytosolic pathogens. Chapter 4 describes work demonstrating that Toxoplasma strain-specifically modulates the innate immune response via secretion of a parasite factor, MAF1, which recruits host mitochondria to the parasitophorous vacuole. Finally, Chapter 5 discusses the future directions and implications of this work in the broader context of host-pathogen interactions.
  • "Completely updated and expanded, 'Emans, Laufer, and Goldstein's Pediatric and Adolescent Gynecology', Sixth Edition, covers the medical and surgical approaches to common pediatric and adolescent clinical problems. The book discusses the importance of the history and physical examination and the physiology of puberty and its associated disorders and complications"--Provided by publisher.
  • Features of embitterment -- Embitterment -- a larger perspective on a forgotten emotion / Hansjö̲rg Znoj -- Hope and embitterment / Beate Schrank, Astrid Grant Hay -- Embitterment -- from the perspective of justice psychology / Claudia Dalbert -- Revenge after trauma; theoretical outline / Ira Gäbler, Andreas Maercker -- "She looks back without bitterness": Wisdom as a developmental opposite of embitterment / Judith Glück -- Personality as risk and resilience in embitterment reactions / Anja Dodek, Sven Barnow -- Neurobiological correlates of social exclusion and social pain / Anna K. Berkefeld, Dieter F. Brauss -- Context of embitterment -- Relationships and embitterment / Kurt Hahlweg, Donald H. Baucom -- Self-regulation of bitterness across the lifespan / Carsten Wrosch, Jesse Renaud -- Cancer patients: loss of meaning, demoralization and embitterment / Anja Mehnert, Sigrun Vehling -- Embitterment and the workplace / Beate Muschalla, Michael Linden -- Embittermenta in Asia: losing face, inequality and alienation under historical and modern perspectives / Changsu Han -- Embitterment and personality disorder / Max Rotter -- Context of embitterment -- Embitterment syndrome: options for psychopharmacological management / Borwin Bandelow -- Forgiveness therapy to treat embitterment: a review of relevant research / Nathaniel G. Wade, Brian C. Post, Marilyn A. Cornish -- Wisdom psychotherapy / Barbara Lieberei, Michael LInden -- Embitterment and forgiveness in the context of the conflict in Northern Ireland / Ed Cairns, Miles Hewstone -- Classification of embitterment -- PTSD and beyond: embitterment and relevant concepts of nosology / Andreas Maercker -- Embitterment in suicide and homicide-sucide / Kenneth R. Conner, Robert L. Weisman -- Should embitterment be included among mental disorders? / Norman Sartorius -- Posttraumatic embitterment disorder, PTED / Michael Linden -- Classification of "reactive" mental disorders in ICD and DSM / Michael B. First -- Contextual facators and reacative disorders in the International Classification of Functioning, Disability and Health / Cille Kennedy, T. Bedirhan Üstün -- Reactive mental disorders: stressors, personality and symptoms / Patricia Casey.
  • Also available: Print – 2005
  • Embolisation 2012
  • Embolization 2014
    Innovations in catheterization techniques and embolization agents have considerably contributed to the development of endovascular occlusion techniques in arterial and venous trunks as much as distal parenchymal capillar beds. Mini invasive therapies, endovascular embolization and chemo-embolization now constitute valuable therapeutic alternatives in various fields: on a purely palliative or on a curative basis in oncology, but also in traumatology, functional diseases, and for the treatment of benign tumors, or when dealing with post-operative complications. As in-depth and detailed descriptions of these techniques are all ready available in specialized books, our ambition is to provide a basic handbook for the young vascular radiologists in training and a checklist for the more experienced interventional radiologists, by providing for each of the constantly increasing indications a synthetic approach of the technique and its expected results. The first part of this book relates to the tool box (the materials) and the procedure techniques as well as the physiopathological requirements for carrying out embolization; the second part is an analytical description of the main situations and anatomo-clinical strategies. This handy book should to be a valuable memory aid for clinicians and interventional radiologists, readily available in the multidisciplinary staff rooms and in angiography suites.
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    How does an embryo form? -- How do the placenta and fetal membranes form? -- The body cavities and the diaphragm -- The integumentary, skeletal, and muscular systems -- The respiratory system -- The cardiovascular system -- The digestive system -- The urinary system -- The reproductive system -- The nervous system -- Development of the head and neck, the eye, and the ear.
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  • Immune privilege of stem cells / Naoki Ichiryu and Paul J. Fairchild -- Immunogenicity of in vitro maintained and matured populations : potential barriers to engraftment of human pluripotent stem cell derivatives / Chad Tang, Irving L. Weissman, and Micha Drukker -- Hematopoietic and nature killer cell development from human pluripotent stem cells / Zhenya Ni, David A. Knorr, and Dan S. Kaufman -- Evaluation of immunogenicity of rat ES-cell derived endothelial cells / Martina Seifert and Juliane Ladhoff -- Interaction of ES cell derived neural progenitor cells with natural killer cells and cytotoxic T cells / Casimir de Rham and Jean Villard -- Strategies to generate induced pluripotent stem cells / Michael Hayes and Nicholas Zavazava -- Differentiation and lineage commitment of murine embryonic stem cells into insulin producing cells / Sudhanshu P. Raikwar and Nicholas Zavazava -- Mouse ES cell-derived hematopoietic progenitor cells / Eun-Mi Kim, Gohar Manzar, and Nicholas Zavazava -- Directed differentiation of embryonic stem cells to the T-lymphocyte lineage / Haydn C.-Y. Liang, Roxanne Holmes, and Juan Carlos Zúñiga-Pflücker -- Development of hematopoietic stem and progenitor cells from mouse embryonic stem cells, in vitro, supported by ectopic human HOXB4 expression / Sandra Pilat, Sebastian Carotta, and Hannes Klump -- Histone modification profiling in normal and transformed human embryonic stem cells using micro chromatin immunoprecipitation, scalable to genome-wide microarray analyses / Angelique Schnerch, Shravanti Rampalii, and Mickie Bhatia -- Combined total proteomic and phosphoproteomic analysis of human pluripotent stem cells / Junjie Hou ... [et al.] -- Transcriptional regulatory mechanisms that govern embryonic stem cell fate / Satyabrata Das and Dana Levasseur.
  • Embryonic stem cell protocols. 2nd ed. v. 1-2, 2006
    Springer Protocols
    v. 2, 2006 Springer Protocols
    v. 1. Isolation and characterization -- v. 2. Differentiation models.
  • Embryonic stem cells 2006
    Also available: Print – 2006
    Derivation and maintenance of embryonic stem cells -- Differentiation of embryonic stem cells.
  • Defined culture media for human embryonic stem cells / T. Ludwig and J. Thomson -- Generation of disease-specific human embryonic stem cell lines / S. Minger -- Characterization and differentiation of human embryonic stem cells / A. Laslett ... [et al.] -- Genetic modification of human embryonic stem cells / T. Zwaka -- Hematopoietic differentiation / C. Cerdan ... [et al.] -- Neural differentiation / Z.-J. Zhang ... [et al.] -- Germ cell differentiation / V. Angeles and R. Pera -- Mesodermal differentiation / N. Sharon and N. Benvenisty -- Three-dimensional culture of human embryonic stem cells / S. Gerecht ... [et al.] -- Extraembryonic cell differentiation / L. Armstrong and M. Lako -- Pancreatic cell differentiation / B. Fishman ... [et al.] -- Cardiomyocyte differentiation / D. Singla ... [et al.] -- Human embryonal carcinoma (EC) cells: Complementary tools for embryonic stem cell research / P. Tonge and P. Andrews -- Quality control of human stem cell lines / G. Stacey.
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    Procedures for deriving ES cell lines from the mouse / Frances A. Brook -- Production of ES cell-derived mice / Yoko Kato and Yukio Tsunoda -- Generating animal models of human mitochondrial genetic disease using mouse ES cells / Grant R. MacGregor ... [et al.] -- Controlling the differentiation of mouse ES cells in vitro / Michael V. Wiles and Gabriele Proetzel -- In vitro differentiation of mouse ES cells into muscle cells / Yelena S. Tarasova [et al.] -- In vitro differentiation of mouse ES cells into haematopoietic cells / Osamu Ohneda and Masayuki Yamamoto -- Lineage selection and transplantation of mouse ES cell-derived neural precursors / Tanja Schmandt, Tamara Glaser and Oliver Brüstle -- In vitro differentiation of mouse ES cells into pancreatic and hepatic cells / Przemyslaw Blyszczuk, Gabriela Kania and Anna M. Wobus -- Isolation and characterization of human ES cells / Martin F. Pera -- Differentiation of human ES cells / Sharon Gerecht-Nir and Joseph Itskovitz-Eldor -- ES cell lines from the cynomolgus monkey (Macaca fascicularis) / Hirofumi Suemori [et al.].
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    The relationship between genotype and phenotype : some basic concepts / Philip Stanier and Gudrun Moore -- Uses of databases in dysmorphology / Michael Baraitser -- Human cytogenetics / J.D.A. Delhanty -- Identification and analysis of genes involved in congenital malformation syndromes / Peter J. Scambler -- Transgenic technology and its role in understanding normal and abnormal mammalian development / Valerie Vidal and Andreas Schedl -- Chemical teratogens : hazards, tools, and clues / Nigel A. Brown -- The limbs / Patrizia Ferretti and Cheryll Tickle -- Brain and spinal cord / Andrew J. Copp -- Birth defects affecting the eye / Jane C. Sowden -- The ear / Sarah L. Spiden and Karen P. Steel -- Development of the enteric nervous system in relation to Hirschsprung's Disease / Heather M. Young, Donald F. Newgreen and Alan J. Burns -- The head / Gillian M. Morriss-Kay -- The heart / Deborah Henderson, Mary R. Hutson and Margaret L. Kirby -- The skin / Ahmad Waseem and Irene M. Leigh -- The vertebral column / David Rice and Susanne Dietrich -- The kidney / Paul J.D. Winyard -- The teeth / Irma Thesleff.
  • This comprehensive guide answers commonly asked questions about neurosurgical conditions related to brain and spinal cord. Emergency Approaches to Neurosurgical Conditions fills the gap which arises after a diagnosis is made on the loved one, explaining the basics of neurosurgical diseases and their management. Emergency Approaches to Neurosurgical Conditions concentrates on the brain and spine, both in surgery and radiotherapy, as well as congenital and accident-related conditions. This comprehensive book which is part of a book-set including Comprehensive Guide to Neurosurgical Conditions, informs the reader on various symptoms to look for, and helps with the management of brain and spine surgery in chapters written by reputed neurosurgeons to help the physicians, the patients and their families.
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  • Introduction to emergency imaging -- Brain -- Head and neck -- Spine -- Chest -- Abdomen and pelvis -- Musculoskeletal -- Pediatrics.
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    Section I. Resuscitation skills and techniques -- Section II. Special considerations in the pediatric patient -- Section III. Head and neck injuries -- Section IV. Gastrointestinal diseases -- Section V. Pulmonary diseases -- Section VI. Cardiac diseases -- Section VII. Vascular diseases -- Section VIII. Injuries to bones and organs -- Section IX. Neurologic diseases -- Section X. Allergic inflammatory, and autoimmune disorders -- Section XI. Genitourinary and renal diseases -- Section XII. Women's health and gynecologic diseases -- Section XIII. Environmental injuries -- Section XIV. Toxicologic emergencies -- Section XV. Bites, stings, and injuries from animals -- Section XVI. Metabolic and endocrine disorders -- Section XVII. Infections -- Section XVIII. Wounds and skin injuries -- Section XIX. Rashes -- Section XX. Emergency psychiatric disorders -- Section XXI. Hematology and oncology management -- Section XXII. Leadership, communication, and administration -- Index.
  • Be prepared to manage increasingly prevalent problems seen in the ED, such as emergent complications of fertility treatment and management of patients who have had bariatric surgery. Deliver high-quality care to your younger patients with expanded pediatrics content. Stay up to date with new chapters on Clotting Disorders and Hemophilia, Patient-Centered Care, Health Disparities and Diversity in Emergency Medicine, Cost-Effectiveness Analysis, Antibiotic Recommendations for Empirical Treatment of Selected Infectious Diseases, and Cardiac Emergency Ultrasound: Evaluation for Pericardial Effusion & Cardiac Activity.
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    Resuscitation -- Cardiovascular emergencies -- Pulmonary emergencies -- Gastrointestinal emergencies -- Urogenital emergencies -- Infectious disease emergencies -- Metabolic emergencies -- Endocrine emergencies -- Neurologic emergencies -- Rheumatologic and allergic emergencies -- Dermatologic emergencies -- Eye, ear, nose, throat, and dental emergencies -- Psychiatric emergencies -- Obstetric and gynecologic emergencies -- Pediatric emergencies -- Hematologic and oncologic emergencies -- Trauma emergencies -- Orthopedic emergencies -- Wound emergencies -- Toxicologic emergencies -- Environmental emergencies -- Emergency medical services -- Disaster medicine -- Legal issues.
  • Emergency medicine-- PreTest self-assessment and review. 3rd ed. 2012
    AccessEmergency Medicine, Users must register and sign in to take a test
    Also available: Print – 2012
    Chest Pain and Cardiac Dysrhythmias -- Shortness of Breath -- Abdominal and Pelvic Pain -- Trauma, Shock and Resuscitation -- Fever -- Poisoning and Overdose -- Altered Mental Status -- Gastrointestinal Bleeding -- Musculoskeletal Injuries -- Headache, Weakness, and Dizziness -- Pediatrics -- Vaginal Bleeding -- Ultrasound in the Emergency Department -- Environmental Exposures -- Eye Pain and Visual Change -- Wound Care -- Prehospital, Disaster, Administration -- Endocrine Emergencies -- Psychosocial Disorders.
  • Emergency medicine procedures. 2nd ed. 2015
    AccessEmergency Medicine
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  • "This book is written and designed to provide medical educators in emergency medicine with resource for integrating medical simulation into their teaching practices. Material is provided in the form of clinical cases which are drawn from a diverse group of faculty authors from a range of major teaching centers. The cases provide readers with a full spectrum of pathology. Moreover, each case is formatted and annotated so that it can be tailored to novice or advanced learners, and easily deployed in a diversity of settings. Valuable "tips or tricks" accompany images patient data. Overall, this book is deal for use by EM educators as part of a tailored teaching and assessment portfolio"--Provided by publisher.
  • This book is a practical guide to the radiologic evaluation of acute musculoskeletal injuries of the upper and lower extremities in children. It covers the detection of more subtle and frequently missed fractures and injuries such as buckle fractures, Salter Harris I and II fractures, and epiphyseal and metaphyseal fractures. It also emphasizes the assessment of soft tissues and periarticular fat pads, which can lead to discovery of the sites of bony injuries. Other pathologies that affect the musculoskeletal system, such as infections and tumors, are also discussed. It includes over 600 magnetic resonance, computed tomography, ultrasound, and radiographic images organized by anatomic region.
  • Emergency neurology 2012
    1. Headache in the Emergency Department / Carrie E. Robertson, David F. Black and Jerry W. Swanson -- 2. Low Back Pain Emergencies / Luis A. Serrano, Tim Maus and J.D. Bartleson -- 3. Dizziness and Vertigo Presentations in the Emergency Department / Kevin A. Kerber and Robert W. Baloh -- 4. Syncope / Mark D. Carlson -- 5. Acute Visual Loss / Cédric Lamirel, Nancy J. Newman and Valérie Biousse -- 6. Diplopia, Third Nerve Palsies, and Sixth Nerve Palsies / Janet C. Rucker -- 7. Facial Nerve Palsy / James M. Gilchrist -- 8. Acute Stroke Evaluation and Management / Ty Tiesong Shang, Dileep R. Yavagal, Jose G. Romano and Ralph L. Sacco -- 9. Intracerebral Hemorrhage / Pratik Vishnu Patel, Lucas Elijovich and J. Claude Hemphill -- 10. Seizures and Status Epilepticus / Sandipan Pati and Joseph I. Sirven -- 11. Central Nervous System Infections / Karen L. Roos -- 12. Weakness (Guillain-Barré Syndrome) / Mengjing Huan and A. Gordon Smith -- 13. Spinal Cord Compression and Myelopathies / William F. Schmalstieg and Brian G. Weinshenker -- 14. Movement Disorder Emergencies / Robert L. Rodnitzky -- 15. Encephalopathy / Steven L. Lewis -- 16. Acute Respiratory Failure in Neuromuscular Disorders / Cynthia L. Bodkin and Robert M. Pascuzzi -- 17. Coma and Brain Death / Robert E. Hoesch and Romergryko G. Geocadin -- 18. Neurotoxicology Emergencies / Laura M. Tormoehlen -- 19. Substance Abuse, Somatization, and Personality Disorders / Ronald Kanner.
  • Emergency Orthopedics is a practical, up-to-date, and comprehensive manual on the diagnosis and treatment of emergency injuries and disorders of the locomotor system. Its problem-based structure, with each chapter addressing a particular symptom, is designed to allow the reader to rapidly locate hands-on advice. For each symptom, facts and findings that will assist in diagnosis are highlighted. Possible diagnoses are suggested according to the ICD-10 code, and the proposed treatment recommendations consider both short- and long-term aspects. The text is supported by exceptionally instructive illustrations, e.g., of examination techniques and reduction maneuvers. The author has extensive practical experience in emergency rooms as well as in sports medicine, research, and education. This book will be a treasure trove of information for all who work in the emergency room and will also be very useful for general practitioners, physiotherapists, and chiropractors.
  • Imaging of Acute Aortic Conditions -- Emergencies of the Biliary Tract -- Acute Appendicitis -- Imaging of Small Bowel -- Imaging of Bowel Obstruction -- Imaging of Acute Colonic Disorders -- Imaging of Genitourinary Emergencies -- Imaging of Acute Conditions of Male Reproductive Organs -- Imaging of Blunt and Penetrating Abdominal Trauma -- Acute Nontraumatic Imaging in the Liver and Spleen -- Imaging of Acute Pancreas -- Imaging of Acute Obstetric Disorders -- Imaging of Acute Gynecologic Disorders -- Emergency Radionuclide Imaging of the Thorax and Abdomen -- Imaging of Neck Emergencies -- Imaging of Acute Head Emergencies -- Imaging of Facial Fractures -- Stroke and Its Imaging Evaluation -- Imaging of Acute Orbital Pathologies -- Imaging of Upper Extremity -- Lower Extremity Trauma -- Imaging of Spinal Trauma -- Imaging of Nontraumatic Mediastinal and Pulmonary Processes -- Imaging of Acute Thoracic Trauma -- Imaging of Lines and Tubes -- Imaging of Pediatric Emergencies.
  • Opening Round -- Fair Game -- Challenge.
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  • Emergency radiology-- case studies 2015
    AccessEmergency Medicine
    Text is specifically designed to help fine-tune emergency radiographic interpretation and problem-solving abilities. Illustrated with hundreds of high-resolution images, this reference covers the full range of clinical problems in which radiographic studies play a key role. Tha author takes you step-by-step through the radiographic analysis of medical, surgical, and traumatic disorders, giving you an unparalleled review of the use and interpretation of radiographic studies in emergency diagnosis.
  • The term "acute abdomen" refers to a serious, often progressive clinical situation that calls for immediate diagnostic and therapeutic action. Today, diagnosis via imaging has basically replaced the physical examination in the emergency room and the Radiologist has become of primary importance in this setting. However, close co-operation among the various specialists involved is essential for successful patient management, and thus the Radiologist needs to have a full understanding of the imaging modalities and technical skills required, as well as appropriate clinical knowledge of t
  • The Requisites series for studying and rotation preparation presents this essential text on emergency radiology. It provides the foundation and the heart of the information you need for the Board exam and every day clinical use. With key features like emergent findings tables and differential diagnoses tables plus 600 high-quality images, this book makes it easy to review important information. Experts on various body systems and modalities of emergency radiology bring you a concise reference that meets all of your study needs.
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  • Also available: Print – 2006
  • Global effects and prevention of emerging and epidemic pathogens: cholera and citrus greening as examples -- Surveillance -- Epidemiological surveillance of highly pathogenic diseases in Kazakhstan -- Surveillance on plague in Natural foci in Georgia -- Application of modern techniques for studying bacterial pathogens in Georgia -- Especially dangerous infections in Azerbaijan -- Strengthening the early-warning function of the surveillance system: the Macedonian experience -- Integrating geographic information systems and ecological niche modeling into disease ecology: a case study of Bacillus anthracis in the United States and Mexico -- Molecular analysis and tools -- Applications of paleomicrobiology to the understanding of emerging and re-emerging infectious diseases -- Characterization of a putative hemagglutinin gene in the caprine model for brucellosis -- Pathoadaptation of especially dangerous pathogens -- Detection of pathogens via high-throughput sequencing -- Environmental infuences on the relative stability of baculoviruses and Vaccinia virus: a review.
  • The role of HLA in MS susceptibility and phenotype -- Sex-based differences in multiple sclerosis (Part I): biology of disease incidence -- Sex-based difference in multiple sclerosis (MS): Part II: rising incidence of multiple sclerosis in women and the vulnerability of men to progression of this disease -- The role of environment and lifestyle in determining the risk of multiple sclerosis -- Evidence for an association between Vitamin D and multiple sclerosis -- Photoimmunology and multiple sclerosis -- Modelling MS: chronic-relapsing EAE in the NOD/Lt mouse strain -- Developing biomarkers for MS -- Helminth Therapy for MS -- Self-assembling peptides form immune suppressive amyloid fibrils effective in autoimmune encephalomyelitis -- Index.
  • Emerging applications of colloidal noble metals in cancer nanomedicine / Jian Zhang & Joseph R. Lakowicz -- Particle characterizations and synthesis methods / Jian Zhang & Joseph R. Lakowicz -- Diagnostics and treatments / Anna M. Sitarski, Jeremy L. Grant, Sanjeev Kumar Kandpal & Michael D. Mason -- Photothermal agents for cell theranostics / Dmitri O. Lapotko -- Drug delivery carriers / Marie-Christine Daniel -- Other applications and future directions / Ismail Ocsoy, Tao Chen & Weihong Tan -- Applications of noble metal nanoparticles in fluorescence sensing / Yi Fu -- Index.
  • Ch. 1. Quantitative radiology: applications to oncology -- Ch. 2. The intricate role of CXCR4 in cancer -- Ch. 3. Recent advances in nanoparticle-based nuclear imaging of cancers -- Ch. 4. Molecular-genetic imaging of cancer -- Ch. 5. Real-time fluorescence image-guided oncologic surgery -- Ch. 6. Cerenkov Imaging -- Ch. 7. Molecular imaging of the tumor microenvironment for precision medicine and theranostics -- Ch. 8. Tracking cellular and immune therapies in cancer -- Ch. 9. Developing MR probes for molecular imaging -- Ch. 10. Clinical translation of molecular imaging agents used in PET studies in cancer -- Index.
  • Neuro-oncology is one of the most exciting and rapidly evolving areas of oncology. In recent years there has been a remarkable increase in activity in the field, from basic science through to the clinic. This is reflected by advances in the understanding of the biology of CNS malignancies which have informed the development of novel and successful therapies. In this environment it is essential to facilitate communication and understanding of new ideas and concepts. Emerging Concepts in Neuro-Oncology is written with this in mind: to encourage collaboration across traditional boundaries and promote translational research for patient benefit. The book moves from concepts in the scientific basis of neuro-oncology in part one, through models of brain cancer in part two, to emerging concepts in clinical practice in part three, with a focus on translational research. This book will be an essential read for neuroscience researchers, cancer researchers, neurosurgeons and clinical oncologists as well as anyone with an interest in this exciting, dynamic field.
  • A global perspective on the management and prevention of emerging and re-emerging diseases Emerging infectious diseases are newly identified or otherwise previously unknown infections that cause public health challenges. Re-emerging infectious diseases are due to both the reappearance of and an increase in the number of infections from a disease that is known, but which had formerly caused so few infections that it was no longer considered a public health problem. The factors that cause the emergence or re-emergence of a disease are diverse. This book takes a look at the worl
  • pt. 1. Identifying emerging pathogens -- pt. 2. Individual pathogens.
  • Store-operated calcium (SOC) entry and channel play a central role in regulating intracellular calcium concentrations in a variety of cell types. SOC is critical for many physiological processes, most notably activation of the immune system, where its lack of function is known to cause severe combined immunodeficiency (SCID) in human patients. In lymphocytes, where SOC has been extensively studied, it has been shown that SOC is mediated by the calcium channel Orai that is activated by its direct binding to STIM, a calcium sensor localized in the endoplasmic reticulum. While it was previously thought that SOC serves an important role only in immune and non-excitable cells, it is now clear that SOC and the proteins that regulate its function are ubiquitously expressed in variety of tissues, including muscle and the nervous system, and serve a diverse set of biological functions. More recently, SOC has been shown to act in a several pathological processes, ranging from muscular dystrophy to cancer, underscoring the significance of gaining a better understanding of its mechanism of action. Here we set out to develop pharmacological blockers of SOC, in order to gain insights into its molecular mechanism and physiological role. Such blockers could allow for acute inhibition of SOC, allowing for a temporal control that is essential for mechanistic studies. If successfully developed, such reagents could also be of therapeutic use as immunosuppressants or anti thrombotic agents in human patients. We designed a novel methodology for generating SOC blockers based on the identification and targeting of minimal functional domains (MFDs) of STIM and Orai. Using this approach, we identified small molecule blockers that can inhibit SOC at high nanomolar concentrations and can also block T cell activation in vitro and in vivo. These studies not only provide an important set of tools for better understanding STIM and Orai function, but also identify compounds that could potentially be developed into therapeutic agents for the treatment of pathological conditions such as autoimmune disease.
  • Emerging oral medications for multiple sclerosis / Sten Fredrikson & Jan Hillert -- Unmet medical needs with current standard treatments / Fredrik Piehl -- Potential drug targets for oral medications / Felix Luessi & Frauke Zipp -- Oral agents for the treatment of RR-MS / Douglas R. Jeffery -- Other therapeutics in the pipeline and future directions / Yuval Karmon, Bijal Mehta & Bianca Weinstock-Guttman -- Index.

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