Books

E

  • 2008 Springer
    edited by Peter Angelos.
    Also available: Print – 2008
  • 2013 Springer
    Norbert Konrad, Birgit Völlm, D.N. Weisstub, editors.
    Recent surveys demonstrate a high and possibly increasing prevalence of mental disorders in prisoners. They have an increased risk of suffering from a mental disorder that transcends countries and diagnoses. Ethical dilemmas in prison psychiatry arise from resource allocation and include issues of patient choice and autonomy in an inherently coercive environment. Ethical conflicts may arise from the dual role of forensic psychiatrists giving raise to tensions between patient care/protection of the public. This book describes models and ethical issues of psychiatric healthcare in prison in several countries. Relevant issues are: the professional medical role of a psychiatrist and/or psychotherapist working in prison, the involvement of psychiatrists in disciplinary or coercive measures; consent to treatment, the use of coercion in forcing a prisoner to undergo treatment, hunger strike, confidentiality. The book ends with consensus guidelines concerning good practice in Prison Psychiatry.
  • 2012 Wiley
    John Jesus, James G. Adams, Shamai A. Grossman, Richard Wolfe, Arthur R. Derse, Peter Rosen.
  • 2011 Stanford Law School
    In response to a request by President Barak Obama on November 24, 2010, the Presidential Commission for the Study of Bioethical Issues oversaw a thorough fact-finding investigation into the specifics of the U.S. Public Health Service-led studies in Guatemala involving the intentional exposure and infection of vulnerable populations. Following a nine-month intensive investigation, the Commission has concluded that the Guatemala experiments involved gross violations of ethics as judged against both the standards of today and the researchers' own understanding of applicable contemporaneous practices. It is the Commission's firm belief that many of the actions undertaken in Guatemala were especially egregious moral wrongs because many of the individuals involved held positions of public institutional responsibility. The best thing we can do as a country when faced with a dark chapter is to bring it to light. The Commission has worked hard to provide an unvarnished ethical analysis to both honor the victims and make sure events such as these never happen again.
  • 2009
    David Seedhouse.
    Status: Not Checked OutLane Catalog Record
    Growing pains -- Ethics is the key -- Problems of practice -- The search for morality -- Persons and potentials -- Theories of ethics -- Obstacles to clear moral reasoning -- The rings of uncertainty -- The background to the ethical grid -- The use of the ethical grid -- The values exchange.
  • 2009
    edited by Steven S. Coughlin, Tom L. Beauchamp, Douglas L. Weed.
    Status: Not Checked OutLane Catalog Record
    Historical foundations / Steven S. Coughlin -- Moral foundations / Tom L. Beauchamp -- Toward a philosophy of epidemiology / Douglas L. Weed -- Epidemiology and informed consent / Jeffrey P. Kahn and Anna C. Mastroianni -- Privacy and confidentiality in epidemiology : special challenges of using information obtained without informed consent / Ellen Wright Clayton -- Ethical issues in the design and conduct of community-based intervention studies / Karen Glanz, Michelle C. Kegler, and Barbara K. Rimer -- Ethical issues in the interaction with research subjects and the disclosure of results / Andrea Smith and Paul A. Schulte -- Ethical issues in public health practice / Robert E. McKeown and R. Max Learner -- Ethical issues in genetic epidemiology / Laura M. Beskow and Wylie Burke -- Ethics and epidemiology in the age of AIDS / Carol Levine -- Ethical issues in international health research and epidemiology / John D.H. Porter, Carolyn Stephens, and Anthony Kessel -- The institutional review board / Robert J. Levine -- Good conduct in integrity in epidemiologic research / Colin L. Soskolne ... [et al.] -- Ethics curricula in epidemiology / Kenneth W. Goodman and Ronald J. Prineas.
  • 2006 Springer
    edited by Sharon E. Sytsma.
    "This collection of 21 articles is designed to serve as a state-of-the art reference book for intersexuals, their parents, health care professionals, ethics committee members and anyone interested in problems associated with intersexuality. It fills an important need because of its uniqueness as an interdisciplinary effort, bringing together not just urologists and endocrinologists, but gynecologists, psychiatrists, psychologists lawyers, theologians, gender theorists, medical historians, and philosophers."--Jacket.
  • 2005 Springer
    edited by Lisa Rasmussen.
    Introduction: in search of ethics expertise -- Socrates and moral expertise -- Aristotle's moral expert: the phronimos -- Hume on true and false philosophy -- Moral expertise: a millian perspective -- The ineffable and the incalculable: G. E. Moore on ethical expertise -- Expert moral choice in medicine: a study of uncertainty and locality -- Societal consensus and the problem of consent: refocusing the problem of ethics expertise in liberal democracies -- Ethical expertise, maternal thinking, and the work of clinical ethicists -- The roles of scientific and normative expertise in public policy formation: the anthrax vaccine case -- Philosophers return to the agora -- Ethical expertise in the clinical setting -- Bioethical expertise in health care organizations -- The expert ethics witness as teacher.
  • 2011 Atypon
    Monique Frize.
    Increasingly, biomedical scientists and engineers are involved in projects, design, or research and development that involve humans or animals. The book presents general concepts on professionalism and the regulation of the profession of engineering, including a discussion on what is ethics and moral conduct, ethical theories and the codes of ethics that are most relevant for engineers. An ethical decision-making process is suggested. Other issues such as conflicts of interest, plagiarism, intellectual property, confidentiality, privacy, fraud, and corruption are presented. General guidelines, the process for obtaining ethics approval from ethics Review Boards,and the importance of obtaining informed consent from volunteers recruited for studies are presented. A discussion on research with animals is included. Ethical dilemmas focus on reproductive technologies, stem cells, cloning, genetic testing, and designer babies. The book includes a discussion on ethics and the technologies of body enhancement and of regeneration. The importance of assessing the impact of technology on people, society, and on our planet is stressed. Particular attention is given to nanotechnologies, the environment, and issues that pertain to developing countries. Ideas on gender, culture, and ethics focus on how research and access to medical services have, at times, been discriminatory towards women. The cultural aspects focus on organ transplantation in Japan, and a case study of an Aboriginal child in Canada; both examples show the impact that culture can have on how care is provided or accepted. The final section of the book discusses data collection and analysis and offers a guideline for honest reporting of results, avoiding fraud, or unethical approaches. The appendix presents a few case studies where fraud and/or unethical research have occurred.
  • 2012 ebrary
    Anji E. Wall.
  • 2014 Springer
    by Shabih H. Zaidi.
    Medical ethics and the medical profession are inseparable, yet the formal teaching of medical ethics is a relatively new phenomenon. Furthermore, since the introduction of managed health care, with the physician becoming a 'health provider' and the patient a 'client', the whole concept of medical ethics has undergone a sea change. The contractual relationship between the provider and the client engenders caution and precaution, resulting in defensive medicine. This book both presents a succinct history of medical ethics and discusses a wide range of important ethical dilemmas in the provision of modern health care. A synopsis is provided of ethics through the ages and the role of ethics in the evolution of medicine. Principles and sources of medical ethics, as well as different religious and secular perspectives, are explained. Ethical concerns in relation to a variety of specific issues are then examined. These issues include, for example, human experimentation, stem cell research, assisted reproductive technologies, termination of pregnancy, rationing of health care, euthanasia, and quality of life issues. The author's many years of practicing medicine in different cultures and countries and his passion for religious works, philosophy, literature, poetry, history, and anthropology have informed and enriched the contents of this stimulating book.
  • 2010 Springer
    edited by Hanfried Helmchen, Norman Sartorius.
    pt. 1. The context -- pt. 2. Principles of ethics in psychiatry -- pt. 3. The applications of the ethical principles in psychiatric practice and research -- pt. 4. Non-medical uses of psychiatry -- pt. 5. Teaching ethics in psychiatry -- pt. 6. Conclusions and summary.
  • 2015 Springer
    Deborah Mascalzoni, editor.
    Biobank research and genomic information are changing the way we look at health and medicine. Genomics challenges our values and has always been controversial and difficult to regulate. In the future lies the promise of tailored medical treatments and pharmacogenomics but the borders between medical research and clinical practice are becoming blurred. We see sequencing platforms for research that can have diagnostic value for patients. Clinical applications and research have been kept separate, but the blurring lines challenges existing regulations and ethical frameworks.Then how do we regulate it? This book contains an overview of the existing regulatory landscape for biobank research in the Western world and some critical chapters to show how regulations and ethical frameworks are developed and work. How should international sharing work? How design an ethical informed consent? An underlying critique: the regulatory systems are becoming increasingly complex and opaque. The international community is building systems that should respond to that. According to the authors in fact, it is time to turn the ship around. Biobank researchers have a moral responsibility to look at and assess their work in relation to the bigger picture: the shared norms and values of current society. Research ethics shouldn?t only be a matter of bioethicists writing guidelines that professionals have to follow. Ethics should be practiced through discourse and regulatory frameworks need to be part of that public discourse. Ethics review should be then not merely application of bureaucracy and a burden for researchers but an arena where researchers discuss their projects, receive advice and practice their ethics skills.
  • 2015 Cambridge
    Kenneth W. Goodman.
    Information technologies and 21st-century clinical practice : ethics and the electronic health record -- Ancient professions and intelligent machines : the ethical challenge of computational decision support -- Health privacy, data protection, and trust -- Professionalism, programming, and pedagogy -- Safety, standards, and interoperability -- The e-health industry : markets, vendors, and regulators -- Digital health : ubiquitous, virtual, remote, robotic -- Biomedical research from genomes to populations : big data and the growth of knowledge.
  • 2006
    edited by John E.J. Rasko, Gabrielle M. O'Sullivan, Rachel A. Ankeny.
    Status: Not Checked OutLane Catalog Record
    Foreword: Shopping at the genetic supermarket / Peter Singer -- Is inheritable genetic modification the new dividing line? / John E.J. Rasko ... [et al.] -- The science of inheritable genetic modification / John E.J. Rasko, Douglas J. Jolly -- Nuclear cloning, embryonic stem cells, and gene transfer / Rudolf Jaenisch -- Controlling bodies and creating monsters: popular perceptions of genetic modifications / Christoph Rehmann-Sutter -- Inheritable genetic modification as moral responsibility in a creative universe / Denis Kenny -- Ethics and welfare issues in animal genetic modification / Gabrielle M. O'Sullivan -- Radical rupture: exploring biologic sequelae of volitional inheritable genetic modification / Francoise Baylis, Jason Scott Robert -- "Alter-ing" the human species? Misplaced essentialism in science policy / Eric T. Juengst -- Traditional and feminist bioethical perspectives on gene transfer: is inheritable genetic modification really the problem? / Rosemarie Tong -- Inheritable genetic modification and disability: normality and identity / Jackie Leach Scully -- Regulating genetic modification: clinical applications and genetic counseling considerations / Joan A. Scott -- Can bioethics speak to politics about the prospect of inheritable genetic modification? If so, what might it say? / Roberta M. Berry -- Glossary of scientific terms / John E.J. Rasko ... [et al.].
  • 2006
    Raymond S. Edge, John Randall Groves.
    Status: Not Checked OutLane Catalog Record
    Human value development -- Decision making in value issues -- Basic principles of health care ethics -- The nature of rights in ethical discourse -- Confidentiality and the management of health care information -- Professional gatekeeping as a function of role fidelity -- Autonomy vs. paternalism: a contest between values -- Justice and the allocation of scarce resources -- Withholding and withdrawing life support -- Euthanasia: practice and principles -- Reproductive issues -- AIDS and health care practice -- Ethical issues and genetic manipulation -- Culturally appropriate health care -- Appendix: codes of professional ethics, selected health professions.
  • 2009 Springer
    Jan Helge Solbakk, Søren Holm, Bjørn Hofmann, editors.
    Pt. 1. Research biobanking : the traditional approach -- Consent to biobank research : one size fits all? / Bjørn Hofmann, Jan Helge Solbakk, Søren Holm -- What no one knows cannot hurt you : the limits of informed consent in the emerging world of biobanking / Arthur L. Caplan -- Users and uses of the biopolitics of consent : a study of DNA banks / Pascal Ducournau and Anne Cambon-Thomsen -- Information rights on the edge of ignorance / Anne Maria Skrikerud -- The dubious uniqueness of genetic information / Anne Maria Skrikerud -- Duties and rights of biobank participants : principled autonomy, consent, voluntariness and privacy / Lars Øystein Ursin -- Biobanking and disclosure of research results : addressing the tension between professional boundaries and moral intuition / Lynn G. Dressler -- Biobanks and our common good / Erik Christensen -- Trust, distrust and co-production : the relationship between research biobanks and donors / Pascal Ducournau and Roger Strand -- Scientific citizenship, benefit, and protection in population-based research / Vilhj́almur Árnason -- Pt. 2. Research Biobanking : towards a new conceptual approach -- Mapping the language of research biobanking : an analogical approach / Bjørn Hofmann, Jan Helge Solbakk, Søren Holm -- The use of analogical reasoning in umbilical cord blood biobanking / Bjørn Hofmann, Jan Helge Solbakk, Søren Holm -- The Alexandria plan : creating libraries for human tissue research and therapeutic use / Laurie Zoloth -- The art of biocollections / Anne Hambro Alnæs -- The health dugnard : biobank participation as the solidary pursuit of the common good / Lars Øystein Ursin and Berge Solberg -- Embodied gifting : reflections on the role of information in biobank recruitment / Klaus Hoeyer -- Conscription to biobank research? / Bjørn Hofmann, Jan Helge Solbakk, Søren Holm -- Ownership rights in research biobanks : do we need a new king of 'biological property'? / Paula Lobato de Faria -- Legal challenges and strategies in the regulation of research biobanking / Elisabeth Rynning -- Annexation of life : the biopolitics of industrial biology / Jan Reinert Karlsen and Roger Strand -- In the ruins of Babel : should biobank regulations be harmonized / Jan Reinert Karlsen, Jan Helge Solbak, and Roger Strand.
  • 2012 Springer
    Niklas Juth, Christian Munthe.
    "Medical or health-oriented screening programs are amongst the most debated aspects of health care and public health practices in health care and public health ethics, as well as health policy discussions. In spite of this, most treatments of screening in the research literature restrict themselves to isolated scientific aspects, sometimes complemented by economic analyses or loose speculations regarding policy aspects. At the same time, recent advances in medical genetics and technology, as well as a rapidly growing societal focus on public health concerns, inspires an increase in suggested or recently started screening programs. This book involves an in-depth analysis of the ethical, political and philosophical issues related to health-oriented screening programs. It explores the considerations that arise when heath care interacts with other societal institutions on a large scale, as is the case with screening: What values may be promoted or compromised by screening programs? What conflicts of values do typically arise - both internally and in relation to the goals of health care, on the one hand, and the goals of public health and the general society, on the other? What aspects of screening are relevant for determining whether it should be undertaken or not and how it should be organised in order to remain defensible? What implications does the ethics of screening have for health care ethics as a whole? These questions are addressed by applying philosophical methods of conceptual analysis, as well as models and theories from moral and political philosophy, medical ethics, and public health ethics, to a large number of ongoing and proposed screening programs which makes this book the first comprehensive work on the ethics of screening. Analyses and suggestions are made that are of potential interest to health care staff, medical researchers, policy makers and the general public"--Provided by publisher.
  • 2013 Wiley
    edited by Ophelia E. Dadzie, Antoine Petit, Andrew F. Alexis.
    Defining ethnic dermatology : challenges, limitations and merits / Ophelia E. Dadzie -- Skin semiology and grading scales in patients with richly pigmented skin / Antoine Petit and Ameet Tailor -- Common skin conditions and ethnicity / Antoine Petit and Moussa Diallo -- Pediatric dermatology and the ethnic patient / Patricia A. Treadwell -- Cutaneous manifestations of systemic diseases / Mahreen Ameen and Fatimata Ly -- Drug eruptions and ethnicity / Jean-Claude Roujeau -- Photodermatoses and phototherapy in the ethnic patient / Richard H. Huggins and Henry W. Lim -- HIV-related skin diseases / Mahreen Ameen and Antoine Mahé -- Benign skin tumours and cysts in the ethnic patient / Nita Agar and Dupe L. Odunsi -- Malignant skin tumours and the ethnic patient / Nita Agar, Bridget Ogawa, and Jean-Jacques Morand -- Treatment of keloids and scars / Martha H. Viera, Alejandra C. Vivas, and Brian Berman -- Vitiligo : clinical presentation and management / Fatima Al Faresi [and others] -- Other causes of hypopigmentation : what not to miss / Ousmane Faye -- Facial hyperpigmentation : a practical approach to diagnosis and management / Camille Fitoussi -- Hair and scalp disorders in women of African descent / Ophelia E. Dadzie and Nonhlanhla P. Khumalo -- Dermatologic disorders in men of African descent / Frederick N. Quarles, Marcelyn Coley, and Andrew F. Alexis -- Hair transplantation in people of African descent / Jack Smadja -- Lasers and the ethnic patient / Heather Woolery-Lloyd and Kristian Figueras -- Cosmetic dermatology in ethnic skin / Leila Ferguson [and others] -- Cosmetic use of skin lightening products / Antoine Mahé.
  • 2013 Springer
    Fady I. Sharara, editor.
    Introduction: the scope of the topic -- Racial and ethnic groups of interest in fertility research -- The impact of sociocultural and economic factors -- Fertility differences among ethnic groups -- Disparities between black and white women in assisted reproductive technology -- Assisted reproductive outcomes in hispanic patients -- Reproductive and assisted reproductive technology (ART) outcomes in East Asian women -- Differences in fertility and assisted reproduction in South Asian women -- Ethnicity and IVF -- Ethnic disparity in oocyte donation outcome -- Frozen embryo transfer outcomes among racial and ethnic groups -- Understanding racial disparity in adverse pregnancy outcome -- Racial diversity and uterine leiomyoma -- The effect of obesity on fertility and ART success among ethnic groups -- Polycystic ovary syndrome across racial and ethnic groups -- Ethnicity and ovariean response: the role of FSH receptor genotype -- Ethnic differences in fertility and assisted reproduction: ethnic disparity in stem cell availability and research -- How can we bridge the gap? Role of insurance mandate -- Toward a better understanding of racial disparities in utilization and outcomes of IVF treatment in the USA.
  • 2008 Springer
    edited by Anthony J. Marsella ... [et al.].
    Essential concepts and foundations / Anthony J. Marsella ... [et al.] -- Promoting disaster recovery in ethnic-minority individuals and communities / Fran H. Norris and Margarita Alegría -- Meeting the physical, psychological, and social needs of African Americans following a disaster / Steven B. Carswell and Melisssa A. Carswell -- Essential information for disaster management and trauma specialists working with American Indians / Jeannette L. Johnson ... [et al.] -- Arab Americans : understanding their challenges, needs, and struggles / Naji Abi-Hashem -- Asian Indians : cultural considerations for disaster workers / B.J. Prashantham -- Caribbean blacks : (Haitians, Jamaicans, Virgin Islanders, Eastern Caribbean) responses to disasters in cultural context / G. Rita Dudley-Grant and Wayne Etheridge -- Chinese Americans : guidelines for disaster mental health workers / Frederick T.L. Leong and Szu-Hui Lee -- The Kanaka Maoli : native Hawaiians and their testimony of trauma and resilience / Laurie D. McCubbin, Michele E. Ishikawa, and Hamilton I. McCubbin -- Mexicans, Mexican Americans, Caribbean, and other Latin Americans / Patricia Arredondo, Veronica Bordes, and Freddy A. Paniagua -- Working with Vietnamese Americans in disasters / Aaron S. Kaplan and Uyen Kim Huynh -- Culture, trauma, and the treatment of post-traumatic syndromes : a global perspective / John P. Wilson -- A brief list of disaster-related vocabulary terms -- Summary and overview of disasters in developing countries / Fran H. Norris -- Disaster rescure and response workers / Bruce H. Young, Julian D. Ford, and Patricia Watson.
  • 2006 Springer
    Christophe Wiart.
    Anti-Inflammatory Plants -- Plants Affecting the Central Nervous System -- Plants for Chemotherapy of Neoplastic Diseases.
  • 2016 Springer
    edited by Toshio Nakanishi, Roger R. Markwald, H.Scott Baldwin, Bradley B. Keller, Deepack Srivastava, Hiroyuki Yamagishi.
    Part I. From Molecular Mechanism to Intervention for Congenital Heart Diseases, Now and Future -- Reprogramming Approaches to Cardiovascular Disease: From Developmental Biology to Regenerative Medicine -- The arterial epicardium, a developmental approach to cardiac disease and repair -- Cell sheet tissue engineering for heart failure -- Future treatment of heart failure and pathophysiological analysis of various heart diseases using human iPS cell-derived cardiomyocytes -- Congenital heart disease: in search of remedial etiologies -- Part II. Left-Right Axis and Heterotaxy Syndrome -- Left-right Asymmetry and Human Heterotaxy Syndrome -- Roles of motile and immotile cilia in left-right symmetry breaking -- Role of cilia and left-right patterning in congenital heart disease -- Pulmonary arterial hypertension in patients with heterotaxy /polysplenia syndrome -- Part III. Cardiomyocyte and Myocardial Development -- Single Cell Expression Analyses of Embryonic Cardiac Progenitor Cells -- Meis1 Regulates Post-Natal Cardiomyocyte Cell Cycle Arrest -- Intercellular signalling in cardiac development and disease: NOTCH -- The epicardium in ventricular septation during evolution and development -- S1P-S1p2 signaling in cardiac precursor cells migration -- Myogenic progenitor cell differentiation is dependent on modulation of mitochondrial biogenesis through autophagy -- The role of the thyroid in the developing heart -- Part IV. Valve Development and Diseases -- Atrioventricular valve abnormalities: From molecular mechanisms underlying morphogenesis to clinical perspective -- Molecular Mechanisms of Heart Valve Development and Disease -- A novel role for endocardium in perinatal valve development: Lessons learned from tissue specific gene deletion of the Tie1 receptor tyrosine kinase -- The Role of the Epicardium in the Formation of the Cardiac Valves in the Mouse -- TMEM100, a novel intracellular transmembrane protein essential for vascular development and cardiac morphogenesis -- Cell autonomous regulation of BMP-2 in endocardial cushion cells during AV valvuloseptal morphogenesis -- Part V. The Second Heart Field and Outflow Tract -- Properties of cardiac progenitor cells in the second heart field -- Nodal signaling and congenital heart defects -- Utilizing Zebrafish to Understand Second Heart Field Development -- A history and interaction of outflow progenitor cells implicated in "Takao syndrome" -- The loss of Foxc2 expression in the outflow tract links the interrupted arch in the conditional Foxc2 knockout mouse -- Environmental modification for phenotype of truncus arteriosus in Tbx1 hypomorphic mice -- Part VI. Vascular Development and Diseases -- Extracellular matrix remodeling in vascular development and disease -- The "cardiac neural crest" concept revisited -- Roles of endothelial Hrt genes for vascular development -- Placental Expression of Type 1 and 3 Inositol Trisphosphate Receptors is Required for the Extra-embryonic Vascular Development -- Tissue Remodeling in Vascular Wall in Kawasaki Disease-related Vasculitis Model Mice -- Part VII. Ductus Arteriosus -- Progerin expression during normal closure of the human ductus arteriosus: A case of premature ageing? -- The multiple roles of prostaglandin E2 in the regulation of the ductus arteriosus -- Developmental Differences in the Maturation of Sarcoplasmic Reticulum and Contractile Proteins in Large Blood Vessels Influences Their Contractility -- Fetal and Neonatal Ductus Arteriosus is Regulated with ATP-sensitive Potassium Channel -- Part VIII. Conduction System and Arrhythmia -- Regulation of vertebrate conduction system development -- Cardiac Pacemaker Development from a Tertiary Heart Field -- Endothelin receptor type A expressing cell population in the inflow tract contributes to chamber formation -- Specific isolation of HCN4 positive cardiac pace-making cells derived from embryonic stem cell -- Part IX. Current Molecular Mechanism in Cardiovascular Development -- Combinatorial functions of transcription factors and epigenetic factors in heart development and disease -- Pcgf5 contributes to PRC1 (Polycomb repressive complex 1) in developing cardiac cells -- non-coding RNAs in cardiovascular disease -- Part X. iPS Cells and Regeneration in Congenital Heart Diseases -- Human pluripotent stem cells to model congenital heart disease -- Engineered cardiac tissues generated from immature cardiac and stem-cell derived cells: Multiple approaches and outcomes -- Dissecting the left heart hypoplasia by pluripotent stem cells -- Lentiviral gene transfer to iPS cells; toward the cardiomyocyte differentiation of Pompe disease-specific iPS cells -- Molecular analysis of long-term cultured cardiac stem cells for cardiac regeneration -- Epicardial contribution in neonatal heart regeneration -- Part XI. Current Genetics in Congenital Heart Diseases -- Genetic discovery for congenital heart defects -- Evidence that deletion of ETS-1, a gene in the Jacobsen syndrome (11q-) cardiac critical region, causes congenital heart defects through impaired cardiac neural crest cell function -- Notch signaling in aortic valve development and disease -- To detect and explore mechanism of CITED2 mutation and methylation in children with congenital heart disease.
  • 2010 Springer
    Alexandrina L. Dumitrescu ; with contributions by Koji Inagaki ... [et al.].
    Etiology of periodontal disease: dental plaque and calculus -- Periodontal microbiology -- Particular aspects of periodontal disease pathogenesis -- Interrelationships between periodontal disease and mortality, cardiovascular disease, metabolic syndrome, diabetes mellitus -- Interrelationships between periodontal disease and adverse pregnancy outcomes, respiratory disease, rheumatoid arthritis, renal disease, cancer, inflammatory bowel disease, Alzheimer disease; Assessing confounding and effect modification -- Genetic variability and periodontal disease -- Implication of systemic osteoporosis on oral health -- Psychological pathways in the pathogenesis of periodontal disease -- Periodontal-restorative interactions -- Endodontic and periodontal interrelationship -- Occlusal considerations in pathogenesis of periodontal disease -- Orthodontics and periodontics.
  • 2016 Springer
    Juan Manuel Mejía-Aranguré, editor.
    Childhood acute leukemias are one of the main causes of death in children aged 1 to 14 years in some countries; and unfortunately, we have been unable to prevent it. Certainly, a good parcel of it is due to the poor understanding about its etiology. This book aims to describe the most important theories and hypothesis regarding childhood acute leukemia. Written by the most outstanding researchers in the field, this book intends to contribute to a greater understanding of the etiology of this disease. It goes beyond the simple and common analysis of risk factors, which hardly allows us to draw definite conclusions. By addressing the etiology of the disease, discussing from molecular biology until epidemiology and clinical manifestations, this book will guide present and future approaches, contributing for a better clinical management of leukemia in children. The knowledge regarding etiology is a crucial step for a better evaluation, prevention and treatment of a disease. Thus, this book finally intends to provide such knowledge, allowing physicians and practitioners to a better manage of childhood acute leukemias.
  • 2015 Springer
    Herbert B. Allen.
    Atopic dermatitis has been called "the itch that rashes", and this book reveals what causes the "itch". It presents completely new and unique findings in eczema: sweat ducts that become occluded with staphylococcal biofilms trigger the innate immune system with TLR2 receptor activity and this leads to production of the "itching" and inflammation in this disease. The Etiology of Atopic Dermatitis details new concepts that bacterial biofilms occlude sweat ducts, trigger the innate immune system, and produce the lesions in atopic dermatitis. The author discusses the findings in terms of microbiology, pathology, immunology, genetics, physiology, treatment, diseases where eczema is considered a secondary component, and diseases not previously thought to be eczema, and followed by an epilogue where eczema and psoriasis are compared. Both these diseases are caused by bacteria, but neither one can be considered an infection. As such, this book is for all who take care of patients with atopic dermatitis, including dermatologists, pediatricians, family practice doctors, allergists and pathologists. It will also be interesting for those involved in research in microbiology, physiology, immunology, and genetics.
  • 1929.
    Guillain, Georges; Alajouanine, Théophile; Mollaret, Pierre.
    Status: Not Checked OutLane Catalog Record
  • 2013
    Thomas H. Lee.
    Flight from Europe, 1929-1939 -- An American education, 1939-1948 -- Medical education and training, 1948-1952 -- Internship and research at Mount Sinai and Bellevue, 1952-1955 -- Clinical associate at the NIH, 1955-1957 -- Johns Hopkins Hospital, 1957-1958 -- The "Golden Years" at the NIH 1958-1968 -- Building a medical school in San Diego, 1968-1972 -- Rebuilding the Brigham, 1972-1980 -- Growth and integration, 1980-1996 -- Research in evolution -- Textbooks and education in evolution -- The still years.
  • 2005 ebrary
    Alexandra Minna Stern.
    Introduction -- 1. Race betterment and tropical medicine in imperial San Francisco -- 2. Quarantine and eugenic gatekeeping on the U.S-Mexico border -- 3. Instituting eugenics in California -- 4. California's eugenic landscapes -- 5. Centering eugenics on the family -- 6. Contesting hereditarianism: reassessing the 1960s -- Epilogue.
    Also available: Print – 2005
  • 2007
    edited by Gáspár Jékely.
    The early eukaryotic fossil record / Emmanuelle J. Javaux -- The diversity of eukaryotes and the root of the eukaryotic tree / Henner Brinkmann and Hervé Philippe -- Origin of eukaryotic endomembranes: a critical evaluation of different model scenarios / Gáspár Jékely -- Origins and evolution of cotranslational transport to the ER / Thomas U. Schwartz -- Evolution of the endoplasmic reticulum and the Golgi complex / Alexander A. Mironov ... [et al.] -- An evolutionary perspective on eukaryotic membrane trafficking / Cemal Gurkan, Atanas V. Koulov, and William E. Balch -- Reconstructing the evolution of the endocytic system: insights from genomics and molecular cell biology / Mark C. Field, Carme Gabernet-Castello, and Joel B. Dacks -- Origins and evolution of the actin cytoskeleton / Francisco Rivero and Fatima Cvrčková -- Origin and evolution of self-consumption: autophagy / Timothy Hughes and Tor Erik Rusten -- Origin and evolution of the centrosome / Michel Bornens and Juliette Azimzadeh -- The evolution of eukaryotic cilia and flagella as motile and sensory organelles / David R. Mitchell.
  • 2012 Springer
    Stuart MacNeill, editor
    Composition and Dynamics of the Eukaryotic Replisome: A Brief Overview / Stuart MacNeill -- Evolutionary Diversification of Eukaryotic DNA Replication Machinery / Stephen J. Aves, Yuan Liu and Thomas A. Richards -- The Origin Recognition Complex: A Biochemical and Structural View / Huilin Li and Bruce Stillman -- Archaeal Orc1/Cdc6 Proteins / Stephen D. Bell -- Cdt1 and Geminin in DNA Replication Initiation / Christophe Caillat and Anastassis Perrakis -- MCM Structure and Mechanics: What We Have Learned from Archaeal MCM / Ian M. Slaymaker and Xiaojiang S. Chen -- The Eukaryotic Mcm2-7 Replicative Helicase / Sriram Vijayraghavan and Anthony Schwacha -- The GINS Complex: Structure and Function / Katsuhiko Kamada -- The Pol [alpha]-Primase Complex / Luca Pellegrini -- The Structure and Function of Replication Protein A in DNA Replication / Aishwarya Prakash and Gloria E. O. Borgstahl -- Structural Biology of Replication Initiation Factor Mcm10 / Wenyue Du, Melissa E. Stauffer and Brandt F. Eichman -- Structure and Function of Eukaryotic DNA Polymerase [delta] / Tahir H. Tahirov -- DNA Polymerase [epsilon] / Matthew Hogg and Erik Johansson -- The RFC Clamp Loader: Structure and Function / Nina Y. Yao and Mike O'Donnell -- PCNA Structure and Function: Insights from Structures of PCNA Complexes and Post-translationally Modified PCNA / Lynne M. Dieckman, Bret D. Freudenthal and M. Todd Washington -- The Wonders of Flap Endonucleases: Structure, Function, Mechanism and Regulation / L. David Finger, John M. Atack, Susan Tsutakawa, Scott Classen and John Tainer, et al. -- DNA Ligase I, the Replicative DNA Ligase / Timothy R. L. Howes and Alan E. Tomkinson.
  • 2008
    David S. Latchman.
    Status: Not Checked OutLane Catalog Record
  • NCBI Bookshelf
  • 2009 Springer
    Karsten E. Dreinhöfer, Paul Dieppe, Klaus-Peter Günther, Wolfhart Puhl.
  • 2015 Springer
    A.D. Katsambas, Torello M. Lotti, Clio Dessinioti, Angelo Massimiliano D'Erme editors.
  • v. 9-, 2009- Springer
  • 2013 Springer
    European Federation of National Associations of Orthopaedics and Traumatology ; edited by George Bentley.
    This thirteenth volume in the EUROPEAN INSTRUCTIONAL LECTURES series continues the format of educational chapters from across Orthopaedics and Traumatology contributed by distinguished Orthopaedic Educators in Europe. It provides current material and major advances covering a range of topics including: General Orthopaedics, Basic Science and Technology, Musculo-skeletal Tumours, Infections, Paediatric Orthopaedics, Trauma, Spine, Upper Limb, Hip, Knee, Leg, Ankle and Foot. All the lectures were presented at the 14th EFORT Congress in Istanbul, Turkey.
  • 2012 Springer
    edited by George Bentley.
    Part 1. Musculo-skeletal Trauma -- The Spectrum of Polytrauma. A Pragmatic Approach for the Musculo-Skeletal Surgeon / Pierre Hoffmeyer and Robin Peter -- Proximal Femoral Fractures / Christopher G. Moran and M. Gaden -- Acute Infections After Osteosynthesis / Volkmar Heppert -- Part 2. Musculo-skeletal Tumours -- The Multi-modal Approach to Metastatic Disease / Minna Laitinen, Maire Ratasvuori and Toni-Karri Pakarinen -- How to Manage Osteolytic Lesions / Jendrik Hardes -- Part 3. Paediatrics -- Developmental Hip Dysplasia - A Problem Solved? / Michael K. D. Benson -- Part 4. Spine -- Infections of the Spine / José Guimarães Consciência, Rui Pinto and T. Saldanha -- Multimodal Treatment of Back Pain / Hans Raimund Casser -- Part 5. Upper Limb -- Proximal Humeral Fractures / Martin Jaeger and N. P. Südkamp -- Part 6. Pelvis and Hip -- Navigation and Hip Surgery / Philippe Merloz -- Re-cementing in Revision Total Hip Replacement / Sarah L. Whitehouse, Matt Wilson, Jonathan R. Howell, Matthew J. W. Hubble and A. John Timperley -- Instability Following Total Hip Arthroplasty / Klaus-Peter Günther, Stephan Kirschner, Maik Stiehler and Albrecht Hartmann -- New Trends in Osteonecrosis of the Femoral Head / Konstantinos N. Malizos and Loukia K. Papatheodorou -- Part 7. Knee -- Patellar Fractures / Jean-Christophe Bel -- Arthroscopic Treatment of Intra-Articular Fractures of the Knee / Reha N. Tandogan -- Treatment of Osteonecrosis of the Knee / Tahsin Beyzadeoglu and Ayberk Onal -- Part 8. Trauma Lower Limb -- Ankle Fractures / Stefan Rammelt and Hans Zwipp -- Part 9. Foot and Ankle -- Treatment of Metatarsalgia / Jean-Luc Besse -- Management of Ankle Osteoarthritis / Matthias G. Walcher, Monika Horisberger, Antony Liddell and Victor Valderrabano.
  • 2011 Springer
    edited by George Bentley.
    Bone Substitutes in Clinical Work / Jari Salo -- Epidemiology and Variability of Orthopaedic Procedures Worldwide / Maria de Fatima de Pina, Ana Isabel Ribeiro, and Carlos Santos -- Cartilage-Forming Bone Tumours / Antonie H.M. Taminiau, Judith V.M.G. Bovée, Carla S.P. van Rijswijk, Hans A.J. Gelderblom, and Michiel A.J. van de Sande -- The Current State of Treatment for Clubfoot in Europe / Rüdiger Krauspe, Kristina Weimann-Stahlschmidt, and B. Westhoff -- Management of Pelvic Fractures / Peter V. Giannoudis and Frangiskos Xypnitos -- The Reverse Shoulder Prosthesis / Carlos Torrens -- Spine Injury: Polytrauma Management / Benny Dahl -- Surgical Management of Tuberculosis of the Spine / Ahmet Alanay and Deniz Olgun -- Scaphoid Fractures / Joseph J. Dias -- Bearing Surfaces / Theofilos Karachalios and George Karydakis -- Hip Pain in the Young Adult / Moritz Tannast, Christoph E. Albers, Simon D. Steppacher, and Klaus A. Siebenrock -- Bone Loss Around the Acetabular Component / Jonathan Howell and Ben Bolland -- The Uni-Knee: Indications, and Recent Techniques / Sébastien Lustig, Gérard Deschamps, M. Alsaati, C. Fary, and Phillippe Neyret -- Osteotomies Around the Knee / Siegfried Hofmann, Philipp Lobenhoffer, Alex Staubli, and Ronald Van Heerwaarden -- Total Knee Replacement for the Stiff Knee / Philippe Massin -- Surgical Treatment of Displaced Calcaneal Fractures / Zvi Cohen, Gershon Volpin, and Haim Shtarker Forefoot Deformities / Wolfgang Schneider.
  • 2014 Springer
    edited by George Bentley.
    General Orthopaedics -- Evidence for Medical Treatment for Tertiary Prophylaxis of Osteoporosis -- Surgical Site Infections (SSIs): Risk Factors and Prevention Strategies -- Exercise Therapy as Treatment for Patients with Osteoarthritis of the Knee -- Tumours -- New Trends Based on Experimental Results in the Treatment of Sarcoma -- Surgery for Soft Tissue Sarcomas -- Trauma -- Biologics in Open Fractures -- Classification and Algorithm of Treatment of Proximal Humerus Fractures -- Management of Proximal Tibial Fractures -- Surgical Treatment of Pelvic Ring Injuries -- Paediatrics -- Anatomical Reconstruction of the Hip with SCFE, Justified by Pathophysiological Findings -- Spine -- Treatment of the Aging Spine -- Shoulder and Elbow -- New Trends in Shoulder Arthroplasty -- Surgery of the Elbow: Evolution of Successful Management -- Forearm -- The Forearm Joint -- Hip -- Current Evidence on Designs and Surfaces in Total Hip Arthroplasty -- Risk Factors and Treatment of Dislocations of Total Hip Arthroplasty -- Treatment of Early and Late Infection Following THA -- Knee -- Prevention and Management of Cartilage Injury and Osteoarthritis from Sports -- Meniscal Lesions Today: Evidence for Treatment -- Modern Indications for High Tibial Osteotomy -- Unicompartment Knee Arthroplasty: From Primary to Revision Surgery -- Foot and Ankle -- Osteotomies Around the Ankle.
  • 2010 Springer
    edited by George Bentley.
    This tenth volume in the EUROPEAN INSTRUCTIONAL LECTURES series continues the format of educational chapters from across Orthopaedics and Traumatology contributed by notable surgeons in Europe. It provides up-to-date material and major advances covering a range of topics including: -General Orthopaedics -Musculo-Skeletal Tumours -Paediatric Orthopaedics -Trauma -Spine -Upper Limb -Hip -Knee -Ankle and Foot All the lectures were presented at the 11th EFORT Congress in Madrid, Spain. The lectures are an authoritative source of information illustrated by radiographs, MRI and CT Scans, operative photographs, tables and line drawings. They are a valuable source of instruction for Surgeons and Trainees alike. This book has been edited by Professor George Bentley. Chairman of Scientific Publications Committee of EFORT.
  • 2015 Springer
    edited by George Bentley.
    Economics of Orthopaedic Infections: A Bottomless Pit -- Updated Animal Models in Orthopaedics Research -- Fractures and Complications Related To Osteoporosis -- RSA Studies in Implant Research -- Instability of the Ankle -- SCFE: Surgical Options -- Proximal Humerus Fractures in Children and Adolescents -- Pelvic Reconstruction in Oncology -- Knee Injuries in Children -- Prevention of Deep Infection in THA -- Revision in Metal-On-Metal THA: Current Knowledge -- Treatment of PJI -- Microbiology/Biofilm/Antibiotics for Dummies -- Diagnostics In PJI -- Patello-Femoral Prosthesis -- Perioperative Management in TKR -- The Role of THR in Patients with Concomitant Back Pain -- Distal Radius Fractures: Indication for Plate Fixation -- Treatment of Fragility Fractures in the Upper Extremity -- Extra capsular Proximal Femur Fractures: Indications for (Primary) Arthroplasty.
  • 2009 Springer
    edited by George Bentley.
  • 2005 Karger
    volume editors, Ibrahim Elmadfa, Elisabeth Weichselbaum.
    Executive summary -- Outlook -- Trends of average food supply in the European Union -- Food availability at the household level in the European Union -- Energy and nutrient intake in the European Union -- Health indicators and status in the European Union -- General discussion.
  • 2009 Karger
    volume editor, Ibrahim Elmadfa.
    Executive summary -- Outlook -- Project background and methodological aspects -- Trends of average food supply in the European Union -- Food availability at the household level in the European Union -- Food consumption in adults on the basis of dietary surveys in European countries -- Energy and nutrient intake in the European Union -- Health and lifestyle indicators in the European Union -- Food and nutrition policies in European countries -- General discussion -- National reports.
  • 2012 Springer
    Patrick Navard, editor.
    This book provides an essential overview of the science of polysaccharides. It both approaches polysaccharides as a polymer class and provides detailed descriptions of most major polysaccharides (cellulose, mannan, xylan, chitin-chitosan, cyclodextrines). Owing to the multidisciplinary character of the European Polysaccharide Network of Excellence (EPNOE), the book describes all main aspects of polysaccharide science and technology (biology, enzymology, physics, chemistry, materials science and processing). Notations and concepts follow a uniform format throughout the whole work in order to create a valuable reference book on the field of polysaccharide science. Owing to the major importance of industry in the EPNOE, concrete applications are also described in detail.
  • 2014 Springer
    George Bentley, editor.
    "This important reference textbook covers the surgical management of all major orthopaedic and traumatological conditions. The book will act as the major source of education and guidance in surgical practice for surgeons and trainees, especially those preparing for higher surgical examinations and the Board of Orthopaedics and Traumatology examinations within and beyond Europe. The emphasis throughout is on the application of current knowledge and research to technical problems, how to avoid operative problems, and how to salvage complications if they occur. The didactic text is complemented by abundant illustrations that highlight the essentials of each clinical scenario. The authors are all recognized international authorities active at congresses and workshops as well as in universities and hospitals across the world."--Publisher's website.
  • 2006
    Hugh Trevor-Roper.
    Status: Not Checked OutLane Catalog Record
    Mayerne and his world -- Early years 1573-1598 -- Paris 1598-1601 -- The grand tour 1599-1601 -- The chemical challenge 1601-1605 -- The German dimension 1605-1606 -- Interlude in England 1606 -- Protestants and Catholics 1600-1610 -- The move to England 1610-1611 -- First years in England 1611-1613 -- Sir Thomas Overbury 1612-1615 -- Secret agent to King James 1614-1615 -- Medical reformer 1615-1616 -- The Protestant revolution 1616-1622 -- Baron d'Aubonne 1620-1621 -- Protector of Switzerland 1622 -- The last years of King James 1623-1625 -- Charles I and the Protestant débâcle 1625-1630 -- A new regime 1630-1631 -- Planting a dynasty 1630-1639 -- Enterpreneur and virtuouso -- The physician and his late years 1640-1655.
  • 2013 Springer
    Richard Brooks.
    The EuroQol Group first met in Rotterdam in May 1987 determined to develop a standardised non-disease-specific instrument for valuing health-related quality of life. The book traces the activities of the Group over the next 25 years. The instrument constructed, eventually named the EQ-5D, was translated into many languages and used in a wide range of countries and settings. The book describes how the instrument's descriptive system was determined, how translation and language issues were handled, and how valuations were provided. Recent developments, in particular a 5-level version (EQ-5D-5L), and a youth version (EQ-5D-Y) are covered. The history of the institutional and administrative framework within which the Group operated is also treated.
  • 2012
    Demetra M. Pappas.
    Status: Not Checked OutLane Catalog Record
    Overview: Emotional public responses to widely publicized right-to-die and euthanasia cases, such as those revolving around Dr. Jack Kevorkian and Terri Schiavo, highlight their volatile mix of medical, ethical, religious, legal, and public policy issues. The Euthanasia/Assisted-Suicide Debate explores how this debate has evolved over the past 100 years as judicial approaches, legislative responses, and prosecutorial practices have shifted as a result of changes in medical technology and consumer sophistication. Emphasizing the period from the 1950s forward, the book offers an unbiased examination of the origins of the modern medical euthanasia and assisted-suicide debates, the involvement of physicians, the history and significance of medical technology and practice, and the role of patients and their families in the ongoing controversy. This illuminating exploration of concepts, issues, and players will help readers understand both sides of the debate as viewed by participants.
  • edited by Christoph Gradmann and Jonathan Simon.
    "This book provides an examination of the regulations that have been successively put into place since the Second World War to standardize the quality and criteria of pharmaceutical products, vaccines and medicines"--Provided by publisher.
  • 2006 NCI
    National Cancer Institute.
  • 2012
    Wei-Nchih Lee.
    Entrusted with providing high quality and cost-effective care across the continuum of primary care to quaternary care medicine, health care institutions are turning to electronic medical records to keep pace with the information demands of medicine. The new patient care data collected within electronic medical records provides the computational foundation to build the rapid learning health care system, in which the delivery of health care within an entire institution improves dynamically by transforming the data into knowledge about which clinical practices are most effective. A crucial component to the rapid learning health care system is an understanding of clinical practice variations in medicine. Individual variations in care reflect decision choices of the treating clinician(s). Taken across an entire population, practice variations offer valuable insight on the behaviors and beliefs of an institution. Devising strategies and policies to improve the quality and efficiency of health care would not be possible without the knowledge that studying practice variations provide. Yet, existing methods for measuring clinical practice variations are not designed to handle temporal complexity. They focus on a small set of practices, of limited duration, and with limited scope. With the data that electronic medical records can provide, we have an opportunity to evaluate temporal complexity in medicine by studying patterns of care and entire treatment histories for a population of patients. In this thesis, I present a method, the T3S, for measuring the temporal sequence similarity between two patterns of care. The T3S advances research in temporal data mining by providing methodology that allows for the measurement of complex temporal features in clinical care. Specifically, the T3S measures the similarity of patterns in terms of the temporal ordering, duration, and overlap of its constituent treatments. I implement the T3S in three novel tools that allow population-level clinical practice variations to be studied from electronic medical records. To begin with, I use the T3S with expert derived domain knowledge to match medication treatment data from the medical record to chemotherapy plans so that patterns of care can be abstracted from granular medical data. This automated method for medical record abstraction of treatment information is a crucial first step before clinical data can be analyzed. Next, I use the T3S to find similar patterns of care from an electronic medical record to recommendations from a clinical practice guideline. The evaluation of individual patterns of care against evidence-based guidelines is an important task of health services related outcomes research. Finally, I incorporate the T3S into a new method for discovering patterns of care from a population of treatment histories. I show how this method can be used to summarize the clinical practice patterns within a population cohort and even discover anomalous practice patterns that may be of interest to clinicians and health services researchers. I evaluate each of these methods for its ability to provide clinically meaningful results from the available treatment data. Taken together, the T3S and the methods in which it is implemented offer a novel framework from which temporal complexities in the practice of medicine can be meaningfully explored. Finding and discovering similar patterns of care offers substantial potential in quality of care, outcomes, and comparative effectiveness research. As medicine marches to the digital age of data, measuring temporal similarity will assume a critical role in the development of new informatics methods to address the challenges of population science.
  • 2007 Springer
    Bengt D. Furbert and Curt D. Furberg.
    Also available: Print – 2007
  • 2011
    Polina A. Segalova.
    Abdominal aortic aneurysms (AAA's) are characterized by a permanent and irreversible enlargement of the abdominal aorta to at least 150 percent its expected normal size. Endovascular treatment of AAA's with endografts has gained tremendous popularity in the last decade, largely due to decreased perioperative mortality and faster recovery times, when compared to open surgical repair. Although endografts are an appealing treatment option for many patients, some device design and safety issues have yet to be addressed. One of the biggest problems with endografts is their tendency to shift their position in the patient anatomy over time. The forces that cause this shift and their relation to endograft design are not well understood. In addition, the degree of blood damage due to the insertion of an endograft into the abdominal aorta has not been quantified. The following studies were completed in order to investigate the issues described above. 1. Calculation of endograft displacement force in patient-specific device models. This study used electron-beam computed tomography (CT) image data to generate patient-specific anatomical models using novel segmentation techniques. The patient models were then virtually modeled to represent three different endograft designs, based on aortic stent-graft devices already available in the U.S. or currently in clinical trials. Computational Fluid Dynamics (CFD) simulations were run to characterize the hemodynamic factors for each patient and a total displacement force was calculated for each model. Results show that the location of the device bifurcation impacts the overall displacement force, with proximal bifurcation endograft designs generating a lesser force than distal bifurcation designs. 2. Characterization of blood damage due to endograft placement. Patient-specific computational models were created to represent endograft features that partially obstruct blood flow to the renal arteries, which is sometimes necessary to attain complete exclusion of the aneurysm after deploying the device. Findings show that the insertion of an endograft causes a two-fold increase in blood damage. However, the magnitude of blood damage is within acceptable safety standards. 3. Benchtop testing of red blood cell damage. A benchtop experimental setup was created to measure the damage to red blood cells under various flow conditions and flow obstructions. Samples were characterized at different time points using light scatter methods to determine cell volume and hemoglobin concentration. Results indicate that significant damage to red blood cells occurs only after prolonged exposure (> 103 seconds) to high shear (> 4000 dynes/cm2) conditions. In addition, the presence of flow obstructions creates red blood cell fragments, instead of destroying the cells entirely. Future directions for this work include additional CFD modeling of devices in more patients treated with different aortic stent graft designs to derive statistical significance relative to various design and anatomical features and extend the analysis to the evaluation of devices used for the treatment of thoracic aortic aneurysms (TAA's). Follow-up studies on device migration studies can also be completed in the cohort of patients where the endograft displacement forces were calculated. Further, blood damage models that incorporate the fragmentation of red blood cells can be developed.
  • 2009 Springer
    Liza H. Gold, Daniel W. Shuman.
    Offers practice guidelines for conducting workplace mental health disability evaluations. This book examines legal and ethical aspects of employment evaluations. It also offers an examination of the process of psychiatric disability development, and discusses issues specific to evaluations for Social Security and other disability benefit programs.
  • 2009 Springer
    Paul Sollie, Marcus Düwell, editors.
    Argues that the world must critically assess the potential pitfalls of new technologies in advance. This book addresses methodological issues with regard to the ethical evaluation of new and emerging technology. It focuses on the concept of uncertainty that, unlike the notion of risk, is greatly undervalued in the field of ethics.
  • 2013
    prepared by Tufts Evidence-based Practice Center ; investigators, Thomas A. Trikalinos, David C. Hoaglin, Kevin M. Small, Christopher H. Schmid.
    BACKGROUND: Existing methods for meta-analysis of diagnostic test accuracy focus primarily on a single index test rather than comparing two or more tests that have been applied to the same patients in paired designs. OBJECTIVES: We develop novel methods for the joint meta-analysis of studies of diagnostic accuracy that compare two or more tests on the same participants. DEVELOPMENT OF METHODS: We extend the bivariate meta-analysis method proposed by Reitsma et al. (J Clin Epidemiol. 2005; 58[10]:982-90) and modified by others to simultaneously meta-analyze M e 2 index tests. We derive and present formulas for calculating the within-study correlations between the true-positive rates (TPR, sensitivity) and between the false-positive rates (FPR, one minus specificity) of each test under study using data reported in the studies themselves. The proposed methods respect the natural grouping of data by studies, account for the within-study correlation between the TPR and the FPR of the tests (induced because tests are applied to the same participants), allow for between-study correlations between TPRs and FPRs (such as those induced by threshold effects), and calculate asymptotically correct confidence intervals for summary estimates and for differences between summary estimates. We develop algorithms in the frequentist and Bayesian settings, using approximate and discrete likelihoods to model testing data. APPLICATION: Published meta-analysis of 11 studies on the screening accuracy of detecting trisomy 21 (Down syndrome) in liveborn infants using two tests: shortened humerus (arm bone), and shortened femur (thigh bone). Secondary analyses included an additional 19 studies on shortened femur only. FINDINGS: In the application, separate and joint meta-analyses yielded very similar estimates. For example, in models using the discrete likelihood, the summary TPR for a shortened humerus was 35.3 percent (95% credible interval [CrI]: 26.9, 41.8%) with the novel method, and 37.9 percent (27.7 to 50.3%) when shortened humerus was analyzed on its own. The corresponding numbers for the summary FPR were 4.8 percent (2.8 to 7.5%) and 4.8 percent (3.0 to 7.4%). However, when calculating comparative accuracy, joint meta-analyses resulted in shorter confidence intervals compared with separate meta-analyses for each test. In analyses using the discrete likelihood, the difference in the summary TPRs is 0 percent (8.9, 9.5%; TPR higher for shortened humerus) with the novel method versus 2.6 percent (14.7, 19.8%) with separate meta-analyses. The standard deviation of the posterior distribution of the difference in TPR with joint meta-analyses is half of that with separate meta-analyses. CONCLUSIONS: The joint meta-analysis of multiple tests is feasible. It may be preferable over separate analyses for estimating measures of comparative accuracy of diagnostic tests. Simulation and empirical analyses are needed to better define the role of the proposed methodology.
  • 2008 ebrary
    Kelly M. Hannum and Jennifer W. Martineau.
    This step-by-step guidebook is designed to help readers understand the importance of evaluation of leadership development initiatives.
  • 2005 Springer
    James G. Anderson, Carolyn E. Aydin, editors.
    Overview: theoretical perspectives and methodologies for the evaluation of healthcare information systems -- Qualitative research methods for evaluating computer information systems -- Multiple perspectives: evaluating healthcare information systems in collaborative environments -- Survey methods for assessing social impacts of computers in healthcare organizations -- Using the Internet for surveys and research -- Cognitive approaches to the evaluation of healthcare information systems -- Work-sampling: a statistical approach to evaluation of the effect of computers on work patterns in health care -- Evaluation of health informatics: social network analysis -- Evaluation in health informatics: computer simulation -- Computers in the consulting room: a case study of clinician and patient perspectives -- Introducing physician order entry at a major academic medical center, A: Impact on organizational culture and behavior, B: Impact on medical education -- Evaluating the capability of information technology to prevent adverse drug events: a computer simulation approach -- Implementing computers in ambulatory care: implications of physician practice patterns for system design -- Nursing documentation time during implementation of an electronic medical record -- Computer charting: an evaluation of a respiratory care computer system -- Research and evaluation: future directions.
  • 2011 Springer
    Adam J. Cohen, David A. Weinberg, editors ; foreword by George Brian Bartley.
    The history of ptosis surgery -- Eyelid anatomy and physiology with reference to blephoraptosis -- Risk factor assessment prior to ptosis surgery -- Ptosis: nailing the diagnosis and considering the differential diagnosis -- Preoperative decision making in ptosis surgery -- Pseudoptosis -- Congenital ptosis -- Involutional ptosis -- Myogenic ptosis -- Myasthenia gravis -- Neurogenic blepharoptosis -- Traumatic blepharoptosis -- Anophthalmic ptosis -- Lash ptosis -- The nonsurgical treatment of ptosis -- External levator resection -- Minimal dissection, small incision ptosis correction -- Muller's muscle-conjunctival resection (posterior approach) -- Open-sky (anterior approach) Muller's muscle resection for the correction of blepharoptosis -- The Fasanella-Servat procedure for ptosis -- Full-thickness eyelid resection for blepharoptosis correction -- Frontalis suspension for the correction of blepharoptosis -- In-office surgery, anesthesia, and analgesia -- Ethnic and gender considerations in ptosis surgery -- Aesthetic considerations for the ptosis surgeon -- Challenging ptosis scenarios -- Ptosis surgery: comparing different surgical techniques -- Ptosis surgery failure and reoperation -- Complications of ptosis repair: prevention and management -- Commentary: perspective of a risk manager: 12 steps of a successful surgical encounter.
  • 2014
    edited by Emma Ciafaloni, Patrick F. Chinnery, Robert C. Griggs.
    Status: Not Checked OutLane Catalog Record
    Structure and function of normal muscle / Robert C. Griggs -- Evaluation of the patient with myopathy / Robert C. Griggs, Emma Ciafaloni -- Genetic evaluation of the patient and family / Gerald Pfeffer, Patrick F. Chinnery -- The muscular dystrophies / Emma Ciafaloni, Robert C. Griggs -- Myofibrillar myopathies / Duygu Selcen -- Congenital myopathies / Francesco Muntoni, Caroline Sewry, Heinz Jungbluth -- Metabolic myopathies / Gráinne S. Gorman, Patrick F. Chinnery -- Mitochondrial myopathy / Gerald Pfeffer, Patrick F. Chinnery -- Muscle channelopathies / Araya Puwanant, Robert C. Griggs -- Inflammatory myopathies / Anthony A. Amato, Andrew Mammen -- Myopathies of systemic disease and toxic myopathies -- Muscle pain and fatigue / Michael R. Rose, Dr. Patrick Gordon -- Prevention and management of systemic complications of myopathies / Wendy M. King, Robert C. Griggs.
  • 2006
    [edited by] David E.E. Holck, John D. Ng.
    Status: Not Checked OutLane Catalog Record
  • 2006 Springer
    Charles P. Friedman, Jeremy C. Wyatt ; foreword by Edward H. Shortliffe ; with contributions by Joan S. Ash, Allen C. Smith III, P. Zoë Stavri, and Mark S. Roberts.
    Challenges of Evaluation in Biomedical Informatics, p. 1-20 -- Evaluation as a Field, p. 21-47 -- Determining What to Study, p. 48-84 -- The Structure of Objectivist Studies, p. 85-112 -- Measurement Fundamentals, p. 113-144 -- Developing and Improving Measurement Methods, p. 145-187 -- The Design of Demonstration Studies, p. 188-223 -- Analyzing the Results of Demonstration Studies, p. 224-247 -- Subjectivist Approaches to Evaluation, p. 248-266 -- Performing Subjectivist Studies in the Qualitative Traditions Responsive to Users / Joan Ash, Allen Smith and P. Starvi, p. 267-300 -- Economic Aspects of Evaluation / Mark Roberts, p. 301-337 -- Proposing and Communicating the Results of Evaluation Studies: Ethical, Legal, and Regulatory Issues, p. 338-361.
    Also available: Print – 2006
  • 2013 Wiley
    by Robert A. Copeland.
    "There has been explosive growth in the hunt for new pharmaceutically agents globally. Traditionally, this has been the purview of the pharmaceutical industry, but today, this effort crosses academic, government, and industry laboratories across the world. Enzymes remain the most valued and common of drug targets; hence, a detailed understanding of their interactions with inhibitors is critical to successful drug discovery. This book provides a practical, readable, and comprehensive treatment of these topics that allows scientists to master the art of applied enzymology for drug discovery. The book addresses the opportunities for inhibitor interactions with enzyme targets arising from consideration of the catalytic reaction mechanism; discusses how inhibitors are properly evaluated for potency, selectivity, and mode of action, covers the potential advantages and liabilities of specific inhibition modalities with respect to efficacy in vivo, and provides valuable biochemical insights to help medicinal chemists and pharmacologists most effectively pursue lead optimization. It includes two new chapters, one on the pioneering idea of drug-target residence time fostered by Dr. Copeland, and the second on quantitative biochemistry. Five new appendices are added"--Provided by publisher.
  • 2005 CRCnetBASE
    edited by John R. Wilson and Nigel Corlett.
  • v. 1-2, 1996-<2014>
    editors, Frederic J. Zucchero, Mark J. Hogan, Christine D. Schultz.
    Status: Not Checked OutLane Catalog Record
  • 1929-
    Evaporated Milk Association.
    Status: Not Checked OutLane Catalog Record
  • 2009
    Trever Bradley Burgon.
    Status: Not Checked OutLane Catalog Record
  • 2006 ScienceDirect
    edited by Christa Neuper, Wolfgang Klimesch.
  • 2013 Wiley
    British Medical Association Ethics Department ; project manager, Veronica English ; written by Ann Sommerville ; editorial board: Sophie Brannan [and others] ; director of professional activities, Vivienne Nathanson.
    A practical approach to ethics -- The doctor-patient relationship -- Consent, choice, and refusal : adults with capacity -- Treating adults who lack capacity -- Treating children and young people -- Confidentiality -- Management of health records -- Prescribing and administering medication.
  • 2001 HighWire
    Also available: Print – 2001
  • 2013 Springer
    Hildebert Wagner, Gudrun Ulrich-Merzenich, editors.
  • 2011 Springer
    Alberto M. Marchevsky, Mark R. Wick, editors.
    Introduction to Evidence-Based Pathology and Laboratory Medicine -- Evidence-Based Pathology: A Stable Set of Principles for a Rapidly Evolving Specialty -- What Is Best Evidence in Pathology? -- Biostatistics 101 -- Prognostication and Prediction in Anatomic Pathology: Carcinoma of the Breast as an Illustrative Model -- Principles of Classification and Diagnosis in Anatomic Pathology and the Inevitability of Problem Cases -- Evaluating Oncopathological Studies: The Need to Evaluate the Internal and External Validity of Study Results -- Power Analysis and Sample Sizes in Pathology Research -- Meta-Analysis: A Statistical Method to Integrate Information Provided by Different Studies -- Decision Analysis and Decision Support Systems in Anatomic Pathology -- Evidence-Based Approach to Evaluate Information Published in the Pathology Literature and Integrate It with Personal Experience -- Evidence-Based Cell Pathology Revisited: A Personal View -- Development of Evidence-Based Diagnostic Criteria and Prognostic/Predictive Models: Experience at Cedars Sinai Medical Cen -- Evaluation and Reduction of Diagnostic Errors in Pathology Using an Evidence-Based Approach -- Meta-Analysis 101 for Pathologists -- Evidence-Based Practices in Applied Immunohistochemistry: Dilemmas Caused by Cross-Purposes -- Evidence-Based Pathology and Laboratory Medicine in the Molecular Pathology Era: Transition of Tests from the Research Bench into Practice -- The Use of Decision Analysis Tools for the Selection of Clinical Laboratory Tests: Developing Diagnostic and Forecasting Models Using Laboratory Evidence -- Implementation and Benefits of Computerized Physician Order Entry and Evidence-Based Clinical Decision Support Systems -- Evidence-Based Pathology and Tort Law: How Do They Compare?
  • 2015 Springer
    Ulrich Schnyder, Marylène Cloitre, editors.
    This book offers an evidence based guide for clinical psychologists, psychiatrists, psychotherapists and other clinicians working with trauma survivors in various settings. It provides easily digestible, up-to-date information on the basic principles of traumatic stress research and practice, including psychological and sociological theories as well as epidemiological, psychopathological, and neurobiological findings. However, as therapists are primarily interested in how to best treat their traumatized patients, the core focus of the book is on evidence based psychological treatments for trauma-related mental disorders. Importantly, the full range of trauma and stress related disorders is covered, including Acute Stress Reaction, Complex PTSD and Prolonged Grief Disorder, reflecting important anticipated developments in diagnostic classification. Each of the treatment chapters begins with a short summary of the theoretical underpinnings of the approach, presents a case illustrating the treatment protocol, addresses special challenges typically encountered in implementing this treatment, and ends with an overview of related outcomes and other research findings. Additional chapters are devoted to the treatment of comorbidities, special populations and special treatment modalities, and to pharmacological treatments for trauma-related disorders. The book concludes by addressing the fundamental question of how to treat whom, and when.
  • 2013 Cambridge
    Anne Andermann.
    "Evidence for Health: From Patient Choice to Global Policy is a practical guide to evidence-informed decision-making. It provides health practitioners and policy-makers with a broad overview of how to improve health and reduce health inequities, as well as the tools needed to make informed decisions that will have a positive influence on health. Chapters address questions such as: What are the major threats to health? What are the causes of poor health? What works to improve health? How do we know that it works? What are the barriers to implementation? What are the measures of success? The book provides an algorithm for arriving at evidence-informed decisions that take into consideration the multiple contextual factors and value judgements involved. Written by a specialist in public health with a wealth of international experience, this user-friendly guide demystifies the decision-making process, from personal decisions made by individual patients to global policy decisions"--Provided by publisher.
  • 2006
    guest editors: Susan E. Reef, Stephen L. Cochi.
  • 2012 Wiley
    Nicky J. Welton, Alexander J. Sutton, Nicola J. Cooper, Keith R. Abrams, A.E. Ades
    Introduction -- Bayesian methods and winBUGS -- Introduction to decision models -- Meta-analysis using Bayesian methods -- Exploring between study heterogeneity -- Model critique and evidence consistency in random effects meta-analysis -- Evidence synthesis in a decision modelling framework -- Multi-parameter evidence synthesis in epidemiological models -- Mixed treatment comparisons -- Markov models -- Generalised evidence synthesis -- Expected value of information for research prioritisation and study design.
  • 2011 Springer
    Thanos Athanasiou, Ara Darzi (Editors).
    Evidence Synthesis: Evolving Methodologies to Optimise Patient Care and Enhance Policy Decisions -- Barriers to Evidence Synthesis -- Systematic Review and Meta-analysis in Clinical Practice -- Diagnostic Tests -- An Introduction to Decision Analysis -- An Introduction to Cost-Effectiveness Analysis -- Evidence Synthesis Using Bayesian Belief Networks -- A Practical Introduction to Meta-analysis -- A Practical Approach to Diagnostic Meta-analysis -- Practical Examples of the Application of Decision Analysis in Healthcare -- A Practical Example of Cost-Effectiveness Analysis -- Exploring Bayesian Belief Networks Using Netica®
  • 2009 ClinicalKey
    edited by Peter M. Miller.
    The addictions treatment field is currently undergoing a period of increased scrutiny, upheaval and change. The growing emphasis on treatment accountability and cost effectiveness is leading to major changes in standards of care. Inconsistent practices based solely on clinical intuition rather than hard scientific evidence of treatment efficacy are rapidly becoming unacceptable. Translating science-based treatments into clinical settings is an important priority in the addictions field and has been the subject of an influential Institute of Medicine report. Substance abuse treatment programs.
  • v. 1-, 2011- Springer
    Cho, William C. S.
  • 2011 Springer
    William C.S. Cho, Editor.
  • 2012 Thieme Book
    Jane Higdon, Victoria J. Drake.
    This evidence-based reference, now in a second edition, presents the most current scientific, epidemiological and clinical research on the role of vitamins and minerals in preventing disease and promoting optimal health. Organized by micronutrient, the book covers biological function, deficiency, recommended daily allowance, role in disease prevention and treatment, sources, safety, and interactions with other micronutrients and drugs - all endorsed by the internationally acclaimed Linus Pauling Institute at Oregon State University.
  • 2014 Springer
    edited by Kathleen Stergiopoulos, David L. Brown.
    This book addresses the increasing demands on cardiology clinicians to manage complex patients with pregnancy, cancer, noncardiac surgery, systemic diseases and concurrent cardiac problems . It provides an up-to-date, detailed, evidence-based approach to key issues facing the consultant including practical clinical advice on the prevention, diagnosis, and treatment of heart disease. Evidence-Based Cardiology Consult addresses the issues specific and relevant to a cardiology consultation and focuses on cardiac issues in both the general medical patient and in specific populations. Topics covered include: The evaluation of chest pain, acute coronary syndromes, heart failure, infective endocarditis, sudden cardiac death, and imaging in cardiology consultation Cardiac problems in women, the elderly and athletes Cardiovascular disease in patients with chronic kidney disease and neurologic disease Pregnancy-related cardiac diseases Cardio-oncology, including cardiac disease resulting from chemotherapy and radiation in oncology patients. This book is a key practical resource for the management of patients with cardiac disease whether it be the primary diagnosis or as a result of other medical conditions. Therefore this is a must read for cardiology trainees and practicing cardiologists, neurologists, physicians in maternalfetal medicine, oncology, nephrology, radiology, and those who participate in preventative medicine programs.
  • 2014 Wiley
    edited by Elizabeth S. Sburlati, Heidi J. Lyneham, Carolyn A. Schniering, and Ronald M. Rapee.
    Machine generated contents note: 1. An Introduction to the Competencies-Based Approach -- 2. Effective Training Methods / Carolyn A. Schniering / Heidi J. Lynehanti / Elizabeth S. Sburlati -- 3. Self-Assessment of Our Competence as Therapists / Emily Jones / Katharina Manassis -- 4. Professional Evidence-Based Practice with Children and Adolescents / James Bennett-Levy / Elizabeth S. Sburlati -- 5. Child and Adolescent Characteristics that Impact on Therapy / Rinad S. Beidas / Julie Edmunds / Matthew Ditty / Margaret Mary Downey -- 6. Building a Positive Therapeutic Relationship with the Child or Adolescent and Parent / Caroline L. Donovan / Sonja March -- 7. Assessing Child and Adolescent Internalizing Disorders / Michael A. Southam-Gerow / Bryce D. McLeod / Ruth C. Brown / Kimberly M. Palter -- 8. Theoretical Foundations of CBT for Anxious and Depressed Youth / Sophie C. Schneider / Carol Newall / Jennifer L. Hudson / Talia Morris -- 9. Case Formulation and Treatment Planning for Anxiety and Depression in Children and Adolescents / Sarah J. Perini / Ronald M. Rapee -- 10. Effectively Engaging and Collaborating with Children and Adolescents in Cognitive Behavioral Therapy Sessions / Heidi J. Lyneham -- 11. Facilitating Homework and Generalization of Skills to the Real World / Philip C. Kendall / Cara A. Settipani / Jeremy S. Peterman -- 12. Managing Negative Thoughts, Part 1: Cognitive Restructuring and Behavioral Experiments / Nikolaos Kazantzis / Philip C. Kendall / Colleen M. Cummings -- 13. Managing Negative Thoughts, Part 2: Positive Imagery, Self-Talk, Thought Stopping, and Thought Acceptance / Shirley Reynolds / Gemma Bowers / Sarah Clark -- 14. Changing Maladaptive Behaviors, Part 1: Exposure and Response Prevention / Sarah Clark / Shirley Reynolds / Maria Loades -- 15. Changing Maladaptive Behaviors, Part 2: The Use of Behavioral Activation and Pleasant Events Scheduling with Depressed Children and Adolescents / Stephen P. Whiteside / Thomas H. Ollendick / Brennan J. Young -- 16. Managing Maladaptive Mood and Arousal / Sandra L. Mendlowitz -- 17. Problem-Solving Skills Training / Caroline E. Kerns / Christina Hardway / Jonathan S. Comer / Donna B. Pincus / Ryan J. Madigan -- 18. Social Skills Training / Ana M. Ugueto / John R. Weisz / Lauren S. Krumholz / Lauren C. Santucci -- 19. Modifying the Family Environment / Lauren C. Santucci / John R. Weisz / Ana M. Ugueto / Lauren S. Krumholz.
  • 2015 Springer
    Paul Ellis Marik.
  • 2014 Wiley
    edited by Hywel C. Williams ; associate editors, Michael Bigby, Andrew Herxheimer, Luigi Naldi, Berthold Rzany, Robert P. Dellavalle, Yuping Ran, Masutaka Furue.
  • 2006 Springer
    edited by Victor M. Montori.
    The new endocrinologist: evidence-based medicine meets endocrine practice / Victor M. Montori -- A short history of evidence-based medicine / Jeanne Daly -- The philosophy of evidence-based medicine, 15 years later / Gordon H. Guyatt and Jason W. Busse -- Preparing future generations of evidence-based endocrinologists / Michael L. Green -- Finding current best evidence in clinical endocrinology / R. Brian Haynes and Cynthia J. Walker-Dilks -- Integrating evidence into clinical diagnosis / W. Scott Richardson -- Supporting evidence-based endocrine practice / Steven A. Smith and Geoffrey Gates -- Helping patients make decisions at the point of care / Annette M. O'Connor, Dawn Stacey, and France Légaré -- Incorporating evidence into health policy decisions / Eduardo Ortiz and Janelle Guirguis-Blake -- The value of observational studies in endocrinology / L. Joseph Melton III -- The value of clinical investigations in endocrinology / William L. Isley -- Systematic reviews and the Cochrane collaboration in endocrinology / Bernd Richter -- Health-related quality of life of in endocrinology / Holger J. Schnemann and Elie A. Akl -- Using decision analyses in endocrinology / David Aron and Evelyn Mentari -- Clouded thinking: the misguided use of cost-effectiveness analysis and the implications for endocrine interventions / Amiram Gafni -- The value of translational research in diabetes: asking broader questions / Russell E. Glasgow, Elizabeth Bayliss, and Paul A. Estabrooks -- The patient with type 1 diabetes and hypoglycemia / Yogish C. Kudva, Teck-Kim Khoo and Peter J. Tebben -- The patient with medically complicated obesity / Kurt A. Kennel -- The patient at risk of type 2 diabetes: considering prevention / Sarah E. Capes -- The patient with type 2 diabetes and incomplete metabolic control / Sean F. Dinneen and Robert K. Semple -- The patient with diabetes using alternative medicine / Edward J. Mills and Dugald Seely -- The patient with osteoporosis / Clifford J. Rosen and Sue A. Brown -- The neuroendocrinology of medically unexplained syndromes: the example of chronic fatigue syndrome / Jason W. Busse.
  • 2007 Ovid
    editors, Pauline M. Camacho, Hossein Gharib, Glen W. Sizemore.
    Hypothalamic-pituitary disorders -- Thyroid disorders -- Adrenal disorders -- Metabolic bone disorders -- Reproductive disorders -- Diabetes mellitus -- Lipid disorders -- Obesity and nutrition -- Multiple endocrine neoplasia -- Carcinoid tumors -- Paraneoplastic endocrine syndromes -- Genetics.
  • 2007 Ovid
    edited by Peter J. Kertes, T. Mark Johnson.
    Clinical epidemiology / Hussein Hollands and Sanjay Sharma -- Health economics / Hussein Hollands and Sanjay Sharma -- Anterior segment / Ayad A. Farjo and Qais A. Farjo -- Refractive surgery / Louis E. Probst -- Clinical trials in glaucoma / Paul E. Rafuse -- Diabetic retinopathy / Dean Eliott -- Diabetic macular edema / Dean Eliott -- Proliferative diabetic retinopathy / Dean Eliott -- Clinical trials in age-related macular degeneration / Sophie J. Bakri and Peter K. Kaiser -- Treatment of central retinal vein occlusion: lessons from clinical trials / Henry Tseng and Sharon Fekrat -- Treatment of branch retinal vein occlusion: lessons from clinical trials / Henry Tseng and Sharon Fekrat -- Retinal detachment and proliferative vitreoretinopathy / Amani A. Fawzi, Jay M. Stewart, and Michael A. Samuel -- Evidence-based medicine and the treatment of endophthalmitis / Seenu M. Hariprasad and William F. Mieler -- Retinopathy of prematurity / Anna Ells -- Amblyopia / Jonathan M. Holmes, Michael X. Repka, and Raymond T. Kraker -- Uveal melanoma: approaches to management / Ernest Rand Simpson -- Optic neuritis / Jonathan D. Trobe -- Thyroid eye disease / Louise A. Mawn -- Traumatic optic neuropathy / Louise A. Mawn.
    Also available: Print – 2007
  • 2014 Ovid
    edited by Peter J. Kertes, T. Mark Johnson.
    "Now in a revised and updated Second Edition, this handy guide to eye care uses evidence from the latest clinical trials to deliver practical advice directly applicable to the challenges of daily ophthalmic practice. Helpful illustrations and tables support the text and improve outcomes, summarizes the major clinical trials in ophthalmology that support the current standard of care. Practical focus helps readers apply research findings to day-to-day practice. Logical organization guides readers from general epidemiology to disease-specific sections. Broad scope addresses the full range of ophthalmologic subspecialties--from treatment of corneal defects, glaucoma, and cataracts to management of vitreo-retinal disorders. NEW in the Second Edition ... Results from the latest clinical trials let readers put current findings into practice. Coverage of new pharmacologic agents broadens therapeutic choices. Three new chapters address arterial occlusive disease, non-exudative age-related macular degeneration, and biostatistics"--Provided by publisher.
  • 2012 Wiley
    edited by Jayna M. Holroyd-Leduc and Madhuri Reddy.
    The latest addition to the Evidence-Based Book series, Evidence-Based Geriatric Medicine provides non-geriatrician clinicians an overview of key topics central to the care of the older patient. This guide focuses on the management of common problems in the elderly taking into account their life situations as well as treatment of specific conditions. Leading geriatricians with expertise in evidence-based medicine utilize the best available evidence and present this information in a concise, easy-to-use, question-based format. Evidence-Based Geriatric Medicine is a unique guide to the optimum management of older patients." Fifty-five full-color narrated video clips on the companion DVD show you clinicians and patients performing the techniques described in the text.
  • 2011 Springer
    L. Santiago Medina, C. Craig Blackmore, Kimberly E. Applegate, editors ; foreward by Bruce J. Hillman.
  • 2006 Springer
    [edited by] L. Santiago Medina, C. Craig Blackmore ; foreword by Bruce J. Hillman.
    Also available: Print – 2006
  • 2010 Springer
    [edited by] L. Santiago Medina, Kimberly E. Applegate, C. Craig Blackmore ; foreword by Jay E. Berkelhamer ; foreword by Bruce J. Hillman.
  • 2012 ScienceDirect
    editors, Simon Dagenais, Scott Haldeman.
  • 2007 ClinicalKey
    [edited by] Daniel I. Steinberg, Jennifer S. Myers, C. Komal Jaipaul.
    "This handbook delivers the assistance you need to provide timely and effective, evidence-based consultations for a range of commonly encountered clinical situations. This book will help you: navigate the most common clinical scenarios requiring medical consultation by reviewing 20-25 clinical questions for each patient type; locate evidence-based answers for each question, collected from the latest clinical findings; and find the information you need quickly thanks to a user-friendly format."--BOOK JACKET.
  • 2008 Springer
    authors, John E. Snyder, Candace C. Gauthier ; foreword by Rosemarie Tong.
  • 2008
    edited by Paul P. Glasziou, Les Irwig, Jeffrey K. Aronson.
    Status: Not Checked OutLane Catalog Record
    An introduction to monitoring therapeutic interventions in clinical practice / Paul P. Glasziou, Jeffrey K. Aronson -- A framework for developing and evaluating a monitoring strategy / David Mant -- Developing monitoring tools: integrating the pathophysiology of disease and the mechanisms of action of therapeutic interventions / Jeffrey K. Aronson, Susan Michie -- Biomarkers and surrogate endpoints in monitoring therapeutic interventions / Jeffrey K. Aronson -- Choosing the best monitoring tests / Les Irwig, Paul P. Glasziou -- Monitoring the initial response to treatment / Katy Bell, Jonathan Craig, Les Irwig -- Control charts and control limits in long-term monitoring / Petra Macaskill -- Developing a monitoring schedule: frequency of measurement / Andrew J. Farmer -- How should we adjust treatment? / Paul P. Glasziou -- Monitoring as a learning and motivational tool / Susan Michie, Kirsten McCaffery, Carl Heneghan -- Monitoring from the patient's perspective: the social and psychological implications / Kirsten McCaffery, Susan Michie -- Evaluating the effectiveness and costs of monitoring / Patrick M.M. Bossuyt -- Good practice in delivering laboratory monitoring / W. Stuart A. Smellie -- Point-of-care testing in monitoring / Christopher P. Price -- Monitoring for the adverse effects of drugs / Jamie J. Coleman, Robin E. Ferner, Jeffrey K. Aronson -- Monitoring diabetes mellitus across the lifetime of illness / Andrew J. Farmer -- Oral anticoagulation therapy (OAT) / Carl Heneghan, Rafael Perera -- Monitoring cholesterol-modifying interventions / Paul P. Glasziou, Les Irwig, Stephane Heritier -- Monitoring levothyroxine replacement in primary hypothyroidism / Andrea Rita Horvath -- Monitoring in renal transplantation / Nicholas B. Cross, Jonathan Craig -- Monitoring in pre-eclampsia / Pisake Lumbiganon, Malinee Laopaiboon -- Monitoring in intensive care / Jan M. Binnekade, Patrick M.M. Bossuyt -- Monitoring intraocular pressure in glaucoma / Les Irwig ... [et al.] -- Monitoring in osteoarthritis / George Peat ... [et al.].
  • 2011
    Sharon E. Straus ... [et al.].
    Status: Not Checked OutLane Catalog Record
    Asking answerable clinical questions -- Acquiring the evidence: how to find current best evidence and have current best evidence find us -- Appraising the evidence -- Therapy -- Diagnosis and screening -- Prognosis -- Harm -- Evaluation -- Teaching EBM.
  • 2014 Wiley
    David Isaacs.
    How to search for evidence -- Epidemiology -- Clinical manifestations -- Laboratory tests -- Rational antibiotic use -- Adjunctive treatment -- Bacterial meningitis -- Respiratory tract infections -- Osteomyelitis and septic arthritis -- Urinary tract infections -- Necrotizing enterocolitis and gastrointestinal infections -- Eye infections -- Skin and soft tissue infections -- Bacterial infections -- Mycoplasmas -- Fungal infections -- Viral infections -- Other congenital infections -- Breast milk -- Surveillance -- Infection control -- Developing countries -- Prevention of neonatal infections -- Neonatal antimicrobials.
  • 2013 Springer
    L. Santiago Medina, Pina C. Sanelli, Jeffrey G. Jarvik, editors.
  • 2006 Thieme eNeurosurgery
    [edited by] Stephen J. Haines, Beverly C. Walters.
    Begins with a review of the concepts and techniques involved in the practice of evidence-based medicine, including the basics of critical analysis using methodologically rigorous evidence-synthesis techniques. The second part of the text provides useful examples of the use of this critical analysis for common clinical situations, such as stent placement, managing infection, metastases, craniocerebral trauma, cervical spine trauma, and more.
  • 2013 Springer
    William C.S. Cho, editor.
  • 2012 Wiley
    Alexander, Sheila A.
    With the aging population ever growing, healthcare for persons suffering from stroke and related illnesses is increasingly important. Evidence-Based Nursing Care in Stroke and Neurovascular Conditions provides a comprehensive and practical guide for novice, experienced and advanced practice nurses working with patients suffering from stroke and other neurovascular conditions. With a focus specifically on neurovascular disorders, this highly detailed text offers easy-to-find information on evidence-based care guidelines.
  • 2009 ClinicalKey
    [edited by] James G. Wright ; section editors, Henry Ahn [and others].
    Dr. James Wright, Associate Editor for the Journal of Bone and Joint Surgery, presents this landmark publication and novel approach to orthopaedic problems and solutions. This new, evidence-based reference examines clinical options and discusses relevant research evidence to provide you with expert recommendations for best practice. The consistent chapter format and featured summary tables provide "at-a-glance" access to the evidence-based literature and clinical options. Leading authorities contribute their expertise so you can apply the most effective clinical solutions to the persistent questions you encounter in your practice.
  • 2008 Springer
    editors, Jennifer J. Shin, Christopher J. Hartnick, Gregory W. Randolph ; section editors, Michael J. Cunningham ... [et al.].
    Also available: Print – 2008
  • 2013 Wiley
    edited by Ross Pinkerton, Ananth G. Shankar, Katherine K. Matthay.
    This book is updated with evidence from the latest published reviews and is more clinically focused, with an emphasis on application of the trial findings. With increased coverage of trials in the area of supportive care for pediatric cancer patients, each chapter opens with a clinical question and concludes with a summary on the trial findings from an expert commentator.
  • 2007
    Steven McGee.
    Status: Not Checked OutLane Catalog Record
  • 2012 ScienceDirect
    2012 ClinicalKey
    Steven McGee.
    Pt. 1. Introduction. What is evidence-based physical diagnosis? -- Pt. 2. Understanding the evidence. Diagnostic accuracy of physical findings -- Using the tables in this book -- Reliability of physical findings -- Pt. 3. General appearance of the patient. Mental status examination -- Stance and gait -- Jaundice -- Cyanosis -- Anemia -- Hypovolemia -- Protein-energy malnutrition and weight loss -- Obesity -- Cushing syndrome -- Pt. 4. Vital signs. Pulse rate and contour -- Abnormalities of pulse rhythm -- Blood pressure -- Temperature -- Respiratory rate and abnormal breathing patterns -- Pulse oximetry -- Pt. 5. Head and neck. The pupils -- Diabetic retinopathy -- Hearing -- Thyroid and its disorders -- Meninges -- Peripheral lymphadenopathy -- Pt. 6. the lungs. Inspection of the chest -- Palpation and percussion of the chest -- Auscultation of the lungs -- Ancillary tests -- Pt. 7. Selected pulmonary disorders. Pneumonia -- Chronic obstructive lung disease -- Pulmonary embolism -- Pleural effusion -- Pt. 8. The heart. Inspection of the neck veins -- Percussion of the heart -- Palpation of the heart -- Auscultation of the heart: general principles -- The first and second heart sounds -- The third and fourth heart sounds -- Miscellaneous heart sounds - Heart murmurs: general principles -- Pt. 9. Selected cardiac disorders. Aortic stenosis -- Aortic regurgitation -- Miscellaneous heart murmurs -- Disorders of the pericardium -- Congestive heart failure -- Coronary artery disease -- Pt. 10. Abdomen. Inspection of the abdomen -- Palpation and percussion of the abdomen -- Abdominal pain and tenderness -- Auscultation of the abdomen -- Pt. 11. Extremities. Peripheral vascular disease -- The diabetic foot -- Edema and deep vein thrombosis -- Examination of the musculoskeletal system -- Pt. 12. Neurologic examination. Visual field testing -- nerves of the eye muscles (III, IV, and VI): approach to diplopia -- Miscellaneous cranial nerves -- Examination of the motor system: approach to weakness -- Examination of the sensory system -- Examination of the reflexes -- Disorders of the nerve roots, plexuses, and peripheral nerves -- Coordination and cerebellar testing -- Pt. 13. Selected neurologic disorders. Tremor and Parkinson disease -- Hemorrhagic versus ischemic stroke -- Acute vertigo and imbalance -- Examination of nonorganic neurologic disorders -- Pt. 14. Examination in the intensive care unit. Examination of patients in the intensive care unit -- Appendix. Likelihood ratios, confidence intervals, and pretest probability.
  • 2010 Springer
    Francesco Chiappelli (editor) ; Xenia Maria Caldeira Brant ... [et al.] (co-editors).
    Introduction: research synthesis in evidence-based clinical decision-making -- Overview, strengths, and limitations of systematic reviews and meta-analyses -- Understanding and interpreting systematic review and meta-analysis results -- Making evidence-based decisions in nursing -- A model for implementing evidence-based decisions in dental practice -- Evidence-based decisions in human immunodeficiency virus infection and cardiac disease -- Bringing evidence basis to decision making in complementary and alternative medicine (CAM): prakriti (constitution) analysis in Ayurveda -- Evidence-based clinical decisions in oral surgery -- Evidence-based issues in maxillofacial trauma -- Strengths and limitations of the evidence-based movement aimed to improve clinical outcomes in dentistry and oral surgery -- Evidence-based decisions for pharmacological management of alcoholic liver disease and alcohol dependence -- Temporomandibular joint disorders, a bibliometric evidence-based approach to analysis -- The efficacy of horizontal and vertical bone augmentation procedures for dental implants: a Cochrane systematic review -- Evidence-based medicine: what does it mean and where are we going? -- Future avenues of research synthesis for evidence-based clinical decision making.
  • 2012 Springer
    Sanjeev Rastogi, editor ; Francesco Chiappelli, Manisha Harish Ramchandani, Ram Harsh Singh, co-editors.
    pt. I. Evidence-Based and Comparative Effectiveness Analysis -- 1. Fundamentals: Evidence-Based Practice in Complementary and Alternative Medicine: Perspectives, Protocols, Problems, and Potentials / Francesco Chiappelli -- pt. II. Evidence-Based Medicine and Ayurveda -- 2. Transforming Ayurveda: Stepping into the Realm of Evidence-Based Practice / Ram Harsh Singh -- 3. Diet and Nutrition Concepts in Ayurveda: Gleaming into Opportunities for Evidence-Based Applications in Health Care / Rajiv Rastogi -- 4. Clinical Evidence in the Tradition of Ayurveda / P. Ram Manohar -- 5. Evidence-Based Traditional Persian Medicine / Francesco Chiappelli -- pt. III. Substantiating Ayurvedic Theory and Practice Toward Evidence-Base -- 6. Prakriti Analysis in Ayurveda: Envisaging the Need of Better Diagnostic Tools / Sanjeev Rastogi -- 7. Panchakarma: Ayurvedic Detoxification and Allied Therapies---Is There Any Evidence? / Ingebritt Ziegler -- 8. Gut and Joint Interconnections: A Reappraisal to Ayurvedic Understanding of Joint Diseases / Ranjana Rastogi -- 9. Ayurvedic Approach to Cardiovascular Diseases: Delineating the Literary and Clinical Evidences / P.S. Srivastav -- 10. Rasayana Therapy and Rejuvenation / Sanjeev Rastogi -- 11. Translational Effectiveness in Ayurvedic Medicine: Implications for Oral Biology and Medicine / Francesco Chiappelli -- pt. IV. Towards Future Perspectives of Evidence-Based Ayurveda -- 12. Safety Aspects of Ayurvedic Drugs / Arun Gupta -- 13. Toward Evidence-Based Practice of Ayurveda: Extrapolating the Challenges in the Current Decade / Sanjeev Rastogi.
  • 2005 Springer
    Ruud ter Meulen, Nikola Biller-Andorno, Christian Lenk, Reidar K. Lie (eds.).
    The ethical debate on evidence-based medicine - introduction to the volume -- Regulating health care. The development of guidelines in medical practice and health policy -- Evidence-based medicine and power shifts in health care systems -- Beyond legitimate science: the case for policy-related science -- Teaching evidence-based medicine -- Evidence-based medicine and clinical guidelines in cardiology. Promoting science, practice, or bureaucracy? -- Are particular patients disadvantaged by EBM? Focus on frail elderly patients -- Evidence-based medicine in mental health: towards better and fairer treatment? -- Current epistemological problems in evidence-based medicine -- Coordinating the norms and values of medical research, medical practice and patient worlds. The ethics of evidence-based medicine in 'boundary fields of medicine' -- Research ethics and evidence-based medicine -- Clinical evaluative research: which patients benefit, how and when? A contribution to a European discussion -- Defining a proper background for discussing evidence-based medicine -- Evidence-based medicine and equity: the exclusion of disadvantaged groups -- The role of formal outcome evaluations in health policy making: a normative perspective -- The usefulness of formal outcome evaluations in health policy making: looking for the baby in the bathwater -- Evidence-based medicine and managed care -- Recommendations from the Evibase project.
  • 2013 ClinicalKey
    [edited by] Lee A. Fleisher.
    1. Evidence-Based Practice Parameters : The Approach of the American Society of Anesthesiologists -- 2. Update on Preprocedure Testing -- 3. Is a Preoperative Screening Clinic Cost-Effective? -- 4. Who Should Have a Preoperative 12-Lead Electrocardiogram? -- 5. Is Routine Preoperative Pregnanc y Testing Necessary? -- 6. What Are the Risk Factors for Perioperative Stroke? -- 7. Should We Delay Surgery in the Patient with Recent Cocaine Use? -- 8. Should All Antihypertensive Agents Be Continued before Surgery? -- 9. What Is the Optimal Timing for Smoking Cessation? -- 10. Which Patient Should Have a Preoperative Cardiac Evaluation (Stress Test)? -- 11. Should Patients with Stable Coronary Artery Disease Undergo Prophylactic Revascularization before Noncardiac Surgery? -- 12. What Are the Role and Management of Percutaneous Coronary Intervention for Noncardiac Surgery? -- 13. How Should We Prepare the Patient with a Pacemaker/Implantable Cardioverter-Defibrillator? -- 14. When Should Pulmonary Function Tests Be Performed Preoperatively? -- 15. Does the Airway Examination Predict Difficult Intubation? -- 16. Is There a Best Approach for Patients with Difficult Airways : Regional versus General Anesthesia? -- 17. What Is the Optimal Airway Management in Patients Undergoing Gastrointestinal Endoscopy? -- 18. Is There a Best Approach to Induction of Anesthesia in Emergent Situations? -- 19. Do Inhalational Agents Have Beneficial or Harmful Effects on Ischemia-Reperfusion Injury? -- 20. Does Anesthetic Choice Affect Surgical and Recovery Times? -- 21. What Are the Benefits of Different Ventilatory Techniques? -- 22. Is There an Optimal Perioperative Hemoglobin Level? -- 23. When Are Platelets and Plasma Transfusions Indicated? -- 24. What Drugs Decrease Perioperative Bleeding? -- 25. Does Perioperative Hyperglycemia Increase Risk? Should We Have Aggressive Glucose Control Perioperatively? -- 26. When and Why Should Perioperative Glucocorticoid Replacement Be Administered? -- 27. Does the Choice of Fluid Matter in Major Surgery? -- 28. What Works in a Patient with Acute Respiratory Distress Syndrome? -- 29. What Actions Can Be Used to Prevent Peripheral Nerve Injury? 30. What Is the Best Means of Preventing Perioperative Renal Injury? -- 31. Does Nitrous Oxide Affect Outcomes? -- 32. Are Alpha-2 Agonists Effective in Reducing Perioperative Cardiac Complications in Noncardiac Surgery? -- 33. What Is the Role of Ketamine in Perioperative Management? -- 34. Should Hypothermia Be Used Routinely after Intraoperative Cardiac Arrest? -- 35. Which Are the Best Techniques for Reducing the Incidence of Postoperative Deep Vein Thrombosis? -- 36. Are There Special Techniques in Obese Patients? -- 37. Is There an Ideal Approach to the Patient Susceptible to Malignant Hyperthermia? -- 38. What Is the Best Strategy for Prevention of Postoperative Nausea and Vomiting? -- 39. How Should Beta-Blockers Be Used Perioperatively? -- 40. How Can We Prevent Postoperative Cognitive Dysfunction? -- 41. Do Intensive Care Specialists Improve Patient Outcomes? -- 42. Fast-Track Cardiac Anesthesia : What Works Best for Safety and Efficacy? -- 43. Can We Prevent Recall during Anesthesia? -- 44. Are Patients with Sleep Apnea Appropriate for Ambulatory Surgery? -- 45. What Criteria Should Be Used for Discharge after Outpatient Surgery? -- 46. What Must I Consider in Order to Safely Anesthetize Someone in the Office Setting? -- 47. Is Propofol Safe If Given by Nonanesthesia Providers? -- 48. Aspiration : Is There an Optimal Management Strategy? -- 49. Nonsteroidal Antiinflammatory Drugs, Antiplatelet Medications, and Spinal Axis Anesthesia -- 50. DVT Prophylaxis with Heparin and Heparin-Like Drugs (UH, LMWH, Fondaparinux, and Rivaroxaban) Used in Combination with Neuraxial Anesthesia and Deep Plexus Blocks -- 51. Is Regional Anesthesia Appropriate for Outpatient Surgery? -- 52. What Is the Best Technique for Hip Surgery? -- 53. Does Intraoperative Regional Anesthesia Decrease Perioperative Blood Loss? -- 54. What Is the Optimal Management of Postdural Puncture Headache? -- 55. Should Ultrasound Guidance Be the Standard of Practice for Peripheral Nerve Blockade? -- 56. Should Regional Anesthesia Be Used for Orthopedic Trauma Patients? -- 57. What Is the Best Method of Diagnosing Perioperative Myocardial Infarction? -- 58. Does Neurologic Electrophysiologic Monitoring Affect Outcome? -- 59. Is Regional Superior to General Anesthesia for Infrainguinal Revascularization? -- 60. Is There a Best Technique to Decrease Blood Loss and Transfusion after Coronary Artery Bypass Grafting? -- 61. Should Thoracic Epidural/Spinal Analgesia be Used for Coronary Artery Bypass Grafting? -- 62. Is There a Best Technique in the Patient with Increased Intracranial Pressure? -- 63. What Works for Brain Protection? -- 64. Anesthesia for Cesarean Delivery : Regional or General? -- 65. When Should a Combined Spinal-Epidural Be Used? 66. Does Labor Analgesia Affect Labor Outcome? -- 67. Does Anesthesia Increase the Risk to the Parturient Undergoing Nonobstetric Surgery? -- 68. How Young Is the Youngest Infant for Outpatient Surgery? -- 69. Should a Child with a Respiratory Tract Infection Undergo Elective Surgery? -- 70. When Should Regional Anesthesia Be Used in Pediatric Patients? -- 71. Optimal Postoperative Analgesia -- 72. Is Pre-Emptive Analgesia Clinically Effective?
  • 2016 ClinicalKey
    [edited by] Clifford S. Deutschman, Patrick J. Neligan.
    Critical care versus critical illness -- What lessons have intensivists learned during the evidence-based medicine era? -- Have critical care outcomes improved? -- What problems are prevalent among survivors of critical illness and which of those are consequences of critical illness? -- Do early warning scores and rapid response teams improve outcomes? -- What are the indications for intubation in the critically ill patient? -- What is the role of noninvasive ventilation in the intensive care unit? -- How does one evaluate and monitor respiratory function in the intensive care unit? -- What is the optimal approach to weaning and liberation from mechanical ventilation? -- How does mechanical ventilation damage lungs? What can be done to prevent it? -- Is extracorporeal life support an evidence-based intervention for critically ill adults with ARDS? -- What factors predispose patients to acute respiratory distress syndrome? -- What is the role of invasive hemodynamic monitoring in critical care? -- Does the use of echocardiography aid in the management of the critically ill? -- How do I manage hemodynamic decompensation in a critically ill patient? -- What are the best tools to optimize the circulation? -- What strategies can be used to optimize antibiotic use in the critically ill? -- Is prophylaxis for stress ulceration useful? -- Should fever be treated? -- What fluids should I give to the critically ill patient? What fluids should I avoid? -- Should blood glucose be tightly controlled in the intensive care unit? -- Is hypothermia useful in managing critically ill patients? Which ones? Under what conditions? -- What are the special considerations in the management of morbidly obese patients in the intensive care unit? -- How do I transport the critically ill patient? -- Are computerized algorithms useful in managing the critically ill patient? -- How do I diagnose and treat pulmonary embolism? -- Should exacerbations of COPD be managed in the intensive care unit? -- What is the clinical definition of ARDS? -- What are the pathologic and pathophysiologic changes that accompany acute lung injury and ARDS? -- What is the best mechanical ventilation strategy in ARDS? -- Is permissive hypercapnia useful in ARDS? -- Do patient positioning in general and prone positioning in particular make a difference in ARDS? -- Is pulmonary hypertension important in ARDS? Should we treat it? -- Inhaled vasodilators in ARDS: do they make a difference? -- Do nonventilatory strategies for acute respiratory distress syndrome work? -- Are anti-inflammatory therapies in ARDS effective? -- What is sepsis? What is septic shock? What are mods and persistent critical illness? -- Is there immune suppression in the critically ill patient? -- What is the role of empirical antibiotic therapy in sepsis? -- What map objectives should be targeted in septic shock? -- What vasopressor agent should be used in the septic patient? -- How can we monitor the microcirculation in sepsis? Does it improve outcome? -- Do the surviving sepsis campaign guidelines work? -- Has outcome in sepsis improved? What has worked? What has not worked? -- How do I diagnose and manage catheter-related bloodstream infections? -- Is selective decontamination of the digestive tract useful? -- Is persistent critical illness an iatrogenic disorder? -- What is the role of autonomic dysfunction in critical illness? -- Is sepsis-induced organ dysfunction an adaptive response? -- How do I manage acute heart failure? -- How is cardiogenic shock diagnosed and managed in the intensive care unit? -- When is hypertension a true crisis, and how should it be managed in the intensive care unit? -- How does one prevent or treat atrial fibrillation in postoperative critically ill patients? -- Is right ventricular failure common in the intensive care unit? How should it be managed? -- How does one rapidly and correctly identify acute kidney injury? -- How does one optimize care in patients at risk for or presenting with acute kidney injury? -- What is the role of renal replacement therapy in the intensive care unit? -- How should acid-base disorders be diagnosed and managed? -- What is the meaning of a high lactate? What are the implications of lactic acidosis? -- How does critical illness alter metabolism? -- Is it really necessary to measure intracranial pressure in brain-injured patients? -- How should traumatic brain injury be managed? -- How should aneurysmal subarachnoid hemorrhage be managed? -- How should acute ischemic stroke be managed in the intensive care unit? -- How should status epilepticus be managed? -- How should Guillain-Barré syndrome be managed in the ICU? -- Is it appropriate to "underfeed" the critically ill patient? -- How does critical illness alter the liver? -- How is acute liver failure managed? -- How does critical illness alter the gut? How does one manage these alterations? -- Is there a place for anabolic hormones in critical care? -- How do I diagnose and manage acute endocrine emergencies in the ICU? -- How does one diagnose, treat, and reduce delirium in the intensive care unit? -- How should trauma patients be managed in the intensive care unit? -- What is abdominal compartment syndrome and how should it be managed? -- How should patients with burns be managed in the intensive care unit? -- What is the best approach to fluid management, transfusion therapy, and the endpoints of resuscitation in trauma? -- How should the critically ill pregnant patient be managed? -- How do I diagnose and manage patients admitted to the ICU after common poisonings? -- How should acute spinal cord injury be managed in the ICU? -- When is transfusion therapy indicated in critical illness and when is it not? -- Which anticoagulants should be used in the critically ill patient? How do I choose? -- How can critical care resource utilization in the united states be optimized? -- Does ICU admission improve outcome? -- How should care within an intensive care unit or an institution be organized? -- What is the role of advanced practice nurses and physician assistants in the ICU? -- What factors influence a family to support a decision withdrawing life support?
  • 2013 ClinicalKey
    [edited by] Nathan E. Goldstein, R. Sean Morrison.
    1. How Should Opioids Be Started and Titrated in Routine Outpatient Settings? -- 2. How Should Opioids Be Started and Titrated in Hospital or Inpatient Settings? -- 3. How Should Patient-Controlled Analgesia Be Used in Patients With Serious Illness and Those Experiencing Postoperative Pain? -- 4. How Should Opioids Be Used to Manage Pain Emergencies? -- 5. What Principles Should Guide Oral, Transcutaneous, and Intravenous Opioid Dose Conversions? -- 6. Which Opioids Are Safest and Most Effective in Renal Failure? -- 7. How Should Methadone Be Started and Titrated in Opioid-Naïve and Opioid-Tolerant Patients? -- 8. What Special Considerations Should Guide the Safe Use of Methadone? -- 9. When Should Corticosteroids Be Used to Manage Pain? -- 10. When Should Nonsteroidal Antiinflammatory Drugs Be Used to Manage Pain? -- 11. What Is Neuropathic Pain? How Do Opioids and Nonopioids Compare for Neuropathic Pain Management? -- 12. Should Bisphosphonates Be Used Routinely to Manage Pain and Skeletal Complications in Cancer? -- 13. Should Bisphosphonates Be Used Routinely to Manage Pain and Skeletal Complications in Other Conditions? -- 14. When Should Radiotherapy Be Considered for Pain Management and What Principles Should Guide the Consideration of Limited-Fraction Versus Full-Dose Radiotherapy? -- 15. When Should Radiopharmaceuticals Be Considered for Pain Management? -- 16. What Principles Should Guide the Prescribing of Opioids for Non-Cancer-Related Pain? -- 17. What Approaches Should Be Used to Minimize Opioid Diversion and Abuse in Palliative Care? -- 18. When Should Epidural or Intrathecal Opioid Infusions and Pumps Be Considered for Pain Management? -- 19. When Should Nerve Blocks Be Used for Pain Management? -- 20. What Interventions Are Effective for Managing Dyspnea in Cancer? -- 21. What Is the Role of Opioids in Treatment of Refractory Dyspnea in Advanced Chronic Obstructive Pulmonary Disease? -- 22. What Nonopioid Treatments Should Be Used to Manage Dyspnea Associated With Chronic Obstructive Pulmonary Disease? -- 23. What Interventions Are Effective for Managing Dyspnea in Heart Failure? -- 24. What Medications Are Effective in Preventing and Relieving Constipation in the Setting of Opioid Use? -- 25. How Should Medications Be Initiated and Titrated to Reduce Acute and Delayed Nausea and Vomiting in the Setting of Chemotherapy? -- 26. How S hould Medications Be Initiated and Titrated to Prevent and Treat Nausea and Vomiting in Clinical Situations Unrelated to Chemotherapy? -- 27. What Interventions Are Effective for Relieving Acute Bowel Obstruction in Cancer and Other Conditions? -- 28. What Medications Are Effective in Improving Anorexia and Weight Loss in Cancer? -- 29. What Therapeutic Strategies Are Effective in Improving Anorexia and Weight Loss in Nonmalignant Disease? -- 30. When Should Enteral Feeding by Percutaneous Tube Be Used in Patients With Cancer and in Patients With Non-Cancer-Related Conditions? -- 31. When Should Parenteral Feeding Be Considered for Patients With Cancer and for Patients With Non-Cancer-Related Conditions? -- 32. How Does One Assess for Psychiatric Illness in Patients With Advanced Disease? -- 33. What Treatments Are Effective for Depression in the Palliative Care Setting? -- 34. What Treatments Are Effective for Anxiety in Patients With Serious Illness? -- 35. What Is Delirium? -- 36. What Are Effective Pharmacological Treatments for Delirium? -- 37. What Nonpharmacological Treatments Are Effective for Delirium? -- 38. What Are the Differences When Treating a Patient at the End of Life With Delirium (Terminal Delirium)? -- 39. How Do Symptoms Change for Patients in the Last Days and Hours of Life? -- 40. What Is Known About Prognostication in Advanced Illness? -- 41. What Is a Useful Strategy for Estimating Survival in Palliative Care Settings for Persons With Advanced Cancer? -- 42. What Is a Useful Strategy for Estimating Survival for Persons With Advanced Non-Cancer-Related Illness in Palliative Care Settings? -- 43. What Are the Key Elements to Having a Conversation About Setting Goals and Communicating Serious News? -- 44. What Do Palliative Care Clinicians Need to Know About Teaching Communication? -- 45. What Are Advance Care Plans and How Are They Different From Advance Directives? -- 46. What Elements Are Essential to Effective Advance Care Planning? -- 47. What Is the Evidence That Advance Care Plans Change Patient Outcomes? -- 48. What Is the Role for Palliative Care in Patients With Advanced Cancer? -- 49. What Is the Clinical Course of Advanced Cancer? -- 50. What Is the Relationsh ip Between Patient Performance Status and Ability to Offer Chemotherapeutic Treatments? -- 51. What Is the Clinical Course of Advanced Dementia? -- 52. What Are Appropriate Palliative Interventions for Patients With Advanced Dementia? -- 53. What Is the Clinical Course of Advanced Liver Disease and What Symptoms Are Associated With It? -- 54. What Special Considerations Are Needed for Treating Patients With Chronic Liver Disease? -- 55. What Is the Role of Palliative Care in Stroke? -- 56. What Special Considerations Are Needed for Individuals With Amyotrophic Lateral Sclerosis, Multiple Sclerosis, or Parkinson Disease? -- 57. What Is the Clinical Course of Advanced Heart Failure and How Do Implanted Cardiac Devices Alter This Course? -- 58. What Is Chronic Critical Illness and What Outcomes Can Be Expected? -- 59. What Special Considerations Are Needed in Patients With Head and Neck Cancer? -- 60. What Special Considerations Are Needed in Treating Symptoms in Patients With End-Stage Renal Disease? -- 61. How Is the Patient Who Stops Dialysis Best Managed? -- 62. Which Patients With End-Stage Renal Disease Should Not Be Started on Dialysis? -- 63. What Is Frailty? -- 64. What Are the Special Needs of Patients With Frailty? -- 65. What Are Special Considerations for Treating Pediatric Patients and Their Families? -- 66. What Are the Signs and Symptoms of Spinal Cord Compression? -- 67. What Are the Best Pharmacological and Surgical Treatments for Patients With Spinal Cord Compression? -- 68. What Techniques Can Be Used in the Hospital or Home Setting to Best Manage Uncontrollable Bleeding? -- 69. What Can Be Done for Patients With Crisis Dyspnea? -- 70. What Are the Arguments That Show That Palliative Care Is Beneficial to Hospitals? -- 71. What Are the Arguments That Show Outpatient Palliative Care Is Beneficial to Medical Systems? -- 72. What Is the Eff ect of Serious Illness on Caregivers? -- 73. What Can Be Done to Improve Outcomes for Caregivers of Patients With Serious Illness? -- 74. What Is Prolonged Grief Disorder and How Can Its Likelihood Be Reduced? -- 75. What Are the Eligibility Criteria for Hospice? -- 76. In What Settings Can Hospice Be Provided? -- 77. What Models Exist for Delivering Palliative Care and Hospice in Nursing Homes? -- 78. How Can Palliative Care Be Integrated Into Home-Based Primary Care Programs? -- 79. What New Models Exist for Ambulatory Palliative Care? -- 80. What New Models Exist for Palliative Care in the Emergency Department? -- 81. What Are Sources of Spiritual and Existential Suffering for Patients With Advanced Disease?
  • 2011 Springer
    edited by Brian Reichow, Peter Doehring, Domenic V. Cicchetti, Fred R. Volkmar.
    Evidence-based practices in autism: Where we started / Brian Reichow and Fred R. Volkmar -- Development, procedures, and application of the evaluative method for determining evidence-based practices in autism / Brian Reichow -- On the reliability and accuracy of the evaluative method for identifying evidence-based practices in autism / Domenic V. Cicchetti -- evidence-based treatment of behavioral excesses and deficits for individuals with autism spectrum disorders / Michael D. Powers, Mark J. Palmieri, Kristen S. D'Eramo, and Kristen M. Powers -- Evidence-based treatments in communication for children with autism spectrum disorders / Patricia A. Prelock, Rhea Paul, and Elizabeth M. Allen -- Treatments to increase social awareness and social skills / Suzannah J. Ferraioli and Sandra L. Harris -- Cognitive behavioral therapy in high-functioning autism: Review and recommendations for treatment development / Jeffrey J. Wood, Cori Fujii, and Patricia Renno -- Psychopharmacology in children with PDD: Review of current evidence / Lawrence Scahill and Susan Griebell Boorin -- Interventions that address sensory dysfunction for individuals with Autism Spectrum Disorders: Preliminary evidence for the superiority of sensory integration compared to other sensory approaches / Roseann C. Schaaf -- Dietary, complementary, and alternative therapies / Susan L. Hyman and Susan E. Levy -- The role of adaptive behavior in evidence-based practices for ASD: Translating intervention into functional success / Katherine D. Tsatsanis, Celine Saulnier, Sara S. Sparrow, and Domenic V. Cicchetti -- Practicing evidence-based practices / Ruth Blennerhassett Eren and Pamela Owen Brucker -- The implementation of evidence-based practices in public schools / Peter Doehring and Vincent Winterling -- Evidence-based practices in autism: Where we are now and where we need to go / Fred R. Volkmar, Brian Reichow, and Peter Doehring.
  • 2012 Springer
    Murad Alam, editor.
    Covers the spectrum of procedural dermatology, including skin cancer surgery, laser techniques, fillers and neurotoxins, minimally invasive cosmetic surgery, and emerging procedures.
  • 2013 Karger
    volume editors, Hania Szajewska, Raanan Shamir.
    Importance of systematic reviews and meta-analyses in pediatric nutrition / Szajewska, H. -- Strengths and weaknesses of observational nutritional trials / Patro-Go B., Szajewska, H. -- Scientific standards for human intervention trials evaluating health benefits of foods, and their application to infants, children, and adolescents / Woodside, J.V., Koletzko, B.V., Patterson, C.C., Welch, R.W. -- Early nutrition and health : short- and long-term outcomes / Gruszfeld, D., Socha, P. -- Probiotics, prebiotics, and dietary fiber in the management of functional gastrointestinal disorders / Horvath, A., Szajewska, H. -- Growing-up milk : a necessity or marketing? / Przyrembel, H, Agostoni, C. -- Cow's milk and goat's milk / Turck, T. -- The timing of introduction of complementary foods and later health / Agostoni, C., Przyrembel, H. -- Dietary interventions for primary allergy prevention -- what is the evidence? / von Berg, A. -- Vitamin and mineral supplementation of term infants : are they necessary? / Lubetzky, R., Mandel, D., Mimouni, F.B. -- Enteral nutrition / Kolaek, S. -- Celiac disease -- prevention strategies through early infant nutrition / Chmielewska, A., Szajewska, H., Shamir, R. -- Interventions for treating obesity in children / De Miguel-Etayo, P., Bueno, G., Garagorri, J.M., Moreno, L.A.
  • 2011 Springer
    Gayle L. Macklem.
    The challenge of providing mental health services in schools -- Evidence-based tier 1, tier 2, and tier 3 mental health interventions in schools -- Strengthening school-counseling interventions -- Affect education at tiers 1, 2, and 3 -- Importance of emotion regulation training for children and adolescents -- Emotion regulation training at tiers 1, 2, and 3 -- Support for the use of CBT in schools -- Preparing young and/or disabled children to benefit from CBT in school-based settings -- CBT in schools -- Sustainability, current programs, and a look to the future.
  • 2013 Springer
    Roger Jankowski.
    The primary nose and palate in evolution -- The primary nose and palate in human embryo development -- Parallels between evolution and development of the nose -- The seemingly simple formation of the secondary palate and nose in the human embryo -- The complex formation of the secondary palate and nose in evolution -- A theory of secondary palate formation -- Primary and secondary palates : primary and secondary nasal fossae -- Olfactory and respiratory nasal fossae -- Is the human ethmoid labyrinth a sinus? -- Understanding the anatomy of the human nose -- Formation of the paranasal air sinues -- The nose in midface development -- Reminder of the normal embryologic development of the human brain -- Phylogenetic origins of the visual and olfactory organs -- Lessons from midface malformations associated to holoprosencephaly -- The evo-devo scenario of nose and midface formation -- A help to teaching anatomy -- Medical hypothesis and perspectives -- Evolutionary and develomental (evo-devo) medicine.
  • 2006 Springer
    K. Shimoji, W.D. Willis, Jr., eds.
  • 2009 Cold Spring Harb Lab Press
    meeting organized by Bruce Stillman, David Stewart, and Jan Witkowski.
  • 2012
    Amanda Morgan Casto.
    Population geneticists have used genome-wide single nucleotide polymorphism (SNP) datasets to investigate the demographic history of humans and to identify regions of the human genome subject to selection. While some general statements can be made about genome as a whole, every genomic locus has its own evolutionary history. The work contained in this dissertation is aimed at elucidating this history for two particular SNP subsets. The first two chapters explore the effects of selection on the X chromosome. Chapter 1 presents evidence that the X chromosome is more frequently a target of selection than the autosomes and identifies regions of the chromosome where selection may have acted. Chapter 2 explores the evolutionary history of one of these regions in depth through haplotype analyses. Chapter 3 investigates the role of selection in the evolution of SNPs with phenotypic associations and finds evidence for selection on SNPs associated with pigmentation, blood pressure, autoimmune disease, and infectious disease susceptibility. Overall, this work as a whole reinforces the conclusion that natural selection acts unevenly throughout the genome and presents evidence for selection on two subsets of genome-wide SNP datasets: X-linked SNPs and SNPs with phenotypic associations.
  • 2006
    Mary Margaret Brinig.
    Status: Not Checked OutLane Catalog Record
  • 2011
    Henry Joseph Folse III.
    In the first chapter, we argue that an individual organism ought not to be defined in terms of genetic homogeneity, but rather by the evolutionary criteria of the alignment of fitness interests, the export of fitness due to interdependence for survival and reproduction, and adaptive functional organization. We consider how these concepts apply to various putative individual organisms, review the costs and benefits of intraorganismal genetic heterogeneity, and demonstrate that high relatedness is neither necessary nor sufficient for individuality. In the second chapter, we model the benefits and costs of genetic mosaicism for a long-lived tree in coevolution with a short-lived pest. We demonstrate benefits of mosaicism for trees at both the individual and population levels when somatic mutation introduces new defenses. In the third chapter, we develop a game theoretic model of the decision to reject or fuse with a potential partner in a colonial ascidian, based on weighing costs and benefits of fusion. We find that once fused, the interactions between cell lineages are cooperative in the soma, but competitive in the germline.
  • 2006 CRCnetBASE
    Roger L. Lundblad.
  • 2006 Springer
    by Martina Newell-McGloughlin and Edward Re.
  • 2011 Springer
    editor, Gerald S. Berenson.
    That precursors of adult coronary artery disease, hypertension, and type II diabetes begin in childhood have been clearly established by the Bogalusa Heart Study. This unique research program has been able to follow a biracial (black/white) population over 35 years from childhood through mid-adulthood to provide perspectives on the natural history of adult heart diseases. Not only do these observations describe trajectories of cardio-metabolic risk variables leading to these diseases but provide a rationale for the need to begin prevention beginning in childhood. The trajectories of the burden of cardio-metabolic risk variables in the context of their fetal origin and chromosome telomere dynamics provide some insight into the metabolic imprinting in utero and aging process. The observed racial contrasts on cardio-metabolic risk variables implicate various biologic pathways interacting with environment contributing to the high morbidity and mortality from related diseases in our population. To address the seriousness of the onset of cardiovascular disease in youth, approaches to primordial prevention are described focussing on childhood health education as an important aspect of Preventive Cardiology.
  • 2013 Springer
    Fred W. Keeley, Robert P. Mecham, editors.
    The evolution of single cells into multicellular organisms was mediated, in large part, by the extracellular matrix. The proteins and glycoconjugates that make up the extracellular matrix provide structural support to cellular complexes, facilitate cell adhesion and migration, and impart mechanical properties that are important for tissue function. Each class of ECM macromolecule has evolved to incorporate distinctive properties that are defined by conserved modules that are mixed together to achieve appropriate function. This volume provides a comprehensive analysis of how the major ECM components evolved over time in order to fill their specific roles found in modern organisms. The major focus is on the structural matrix proteins, matricellular proteins, and more complex ECM structures such as basement membranes. Adhesive proteins and their receptors are also discussed.The series Biology of Extracellular Matrix is published in collaboration with the American Society for Matrix Biology.
    Also available: Print – 2013
  • 2011 Springer
    Herman D. Suit, Jay S. Loeffler.
  • 2005 ScienceDirect
    edited by T. Ryan Gregory.
    Genome size evolution in animals / T. Ryan Gregory -- Genome size evolution in plants / Michael D. Bennett and Ilia J. Leitch -- Transposable elements / Margaret G. Kidwell -- B chromosomes / Juan Pedro M. Camacho -- Small-scale gene duplications / John S. Taylor and Jeroen Raes -- Large-scale gene and ancient genome duplications / Yves Van de Peer and Axel Meyer -- Polyploidy in plants / Jennifer A. Tate, Douglas E. Soltis, and Pamela S. Soltis -- Polyploidy in animals / T. Ryan Gregory and Barbara K. Mable -- Comparative genomics in eukaryotes / Alan Filipski and Sudhir Kumar -- Comparative genomics in prokaryotes / T. Ryan Gregory and Rob DeSalle -- Macroevolution and the genome / T. Ryan Gregory.
  • 2008
    Michael Gleimer.
    Status: Not Checked OutLane Catalog Record
  • 2012 ScienceDirect
    edited by Michel A. Hofman, Dean Falk.
    From tetrapods to primates : conserved developmental mechanisms in diverging ecological adaptations / F. Aboitiz and J.F. Montiel -- Genetic correlates of the evolving primate brain / E.J. Vallender -- Cerebral cortical development in rodents and primates / Z. Molnár and G. Clowry -- Embracing covariation in brain evolution : large brains, extended development, and flexible primate social systems / C.J. Charvet and B.L. Finlay -- The evolution of neocortex in primates / J.H. Kaas -- Lateralization of the human brain / M.C. Corballis -- The insular cortex : a review / R. Nieuwenhuys -- The missing link : evolution of the primate cerebellum / C. MacLeod -- Human prefrontal cortex : evolution, development, and pathology / K. Teffer and K. Semendeferi -- Minicolumn size and human cortex / D.P. Buxhoeveden -- Human brain evolution writ large and small / C.C. Sherwood ... [et al.] -- Hominin paleoneurology : where are we now? / D. Falk -- Evolution of hominin cranial ontogeny / C.P.E. Zollikofer -- Hominins and the emergence of the modem human brain / A. de Sousa and E. Cunha -- Neuronal scaling rules for primate brains : the primate advantage / S. Herculano-Houzel -- Self-organization and interareal networks in the primate cortex / H. Kennedy and C. Dehay -- Neural wiring optimization / C. Cherniak -- Design principles of the human brain : an evolutionary perspective / M.A. Hofman -- Primate encephalization / L. Lefebvre -- Evolution of the brain and intelligence in primates / G. Roth and U. Dicke -- Evolution of human emotion : a view through fear / J.E. LeDoux -- Evolution of brain and language / P.T. Shoenemann.
  • 2012 Springer
    Pedro J. Gutiérrez Diez, Irma H. Russo, Jose Russo.
    Historical Introduction -- Descriptive Biostatistics -- Inferential Biostatistics (I): Estimating Values of Biomedical Magnitudes -- Inferential Biostatistics (II): Estimating Biomedical Behaviors -- Equations: Formulating Biomedical Laws and Biomedical Magnitudes -- Systems of Equations: The Explanation of Biomedical Phenomena (I). Basic Questions -- Systems of Equations: The Explanation of Biomedical Phenomena (II). Dynamic Interdependencies -- Optimal Control Theory: From Knowledge to Control (I). Basic Concepts -- Optimal Control Theory: From Knowledge to Control (II). Biomedical Applications -- Game Theory.
  • 2013
    Jordan Vail Price.
    Since the advent of microarray technology in the early 1990's, the development of highly multiplex genomics tools has greatly outpaced the field of proteomics in terms of the generation of useful platforms for basic research and clinical analysis. Yet, to deliver on the great promise of genomics tools that analyze nucleic acids, technologies that permit the analysis of protein-protein interactions on a comparable scale need to be developed. Our group and others have shown that whole-protein and peptide microarrays can provide large amounts of information about the protein interactions that underlie the human immune response in health and disease. Here we describe three novel proteomics microarray platforms and demonstrate that the arrays can be used to gain insight into the antibody-mediated immune response in a spectrum of human diseases. In the first study, we detail the generation of a protein microarray that allows the detection of antibodies that bind to the molecular communication factors of the immune system: cytokines, chemokines, growth factors, and other circulating proteins. Using these arrays, we identified novel targets of autoantibodies in systemic lupus erythematosus, which may delineate a unique subgroup of patients within the spectrum of lupus. In the second study, we describe influenza antigen microarrays that permitted the identification of antibody reactivity to specific influenza hemagglutinin epitopes associated with poor or effective response to the seasonal influenza vaccine. These arrays have potential for development into a clinical diagnostic tool capable of predicting an individual's ability to mount an effective antibody response to vaccination. Finally, we report the development of a silicon-based peptide microarray developed in collaboration with researchers at the Intel Corporation. These "Intel arrays" hold great potential for ultimately enabling highly parallel, real-time measurement of protein-protein interaction with myriad possible downstream applications. The technologies we have developed move the field of multiplex proteomic analysis forward on many fronts, and constitute valuable additions to the proteomics toolkit available to researchers and clinicians. Moreover, our work demonstrates that detailed analysis of protein-protein interaction is required to make more informed models of different states of human health and disease.
  • 2007 MyiLibrary
    Michael L. Arnold.
    History of investigations -- The role of species concepts -- Testing the hypothesis -- Barriers to gene flow -- Hybrid fitness -- Gene duplication -- Origin of new evolutionary lineages -- Implications for endangered taxa -- Humans and associated lineages -- Emergent properties.
  • 2013 Springer
    Albrecht Reichle, editor.
    pt. I. Introduction -- pt. II. Combined modularized therapies for metastic tumors : pointing to central problems of communication among 'systems participators' in tumors -- pt. III. Social engineering : biomodulation, either endogenously initiated or by implementation of non-normative boundary conditions -- pt. IV. The tumors' normativity : reconstructing and operationalizing starting points for an evolution theory -- pt. V. Evolution theory -- pt. VI. From genome- or organ-centric to rationalization-centric systematization of tumors -- pt. VII. Reconstruction of tumor-immanent normative functions, structures and decision maxims (hubs) -- pt. VIII. The tool of rationalizations constituting tumor-associated normative notions : the non-genomic counterpart of the tumor genome and therefore, an important therapeutic target for diversifying palliative care -- pt. IX. Novel clinical and pharmaceutical technology for bioengineering tumor response -- pt. X. Objectifying the systems objects' subjectivity in biological systems : a novel reification of the scientific picture about the 'objective' world.
  • 2011 Springer
    Donald R. Forsdyke.
    Pt. 1. Information and DNA -- pt. 2. Parity and non-parity -- pt. 3. Variation and speciation -- pt. 4. Conflict with genomes -- pt. 5. Conflict between genomes -- pt. 6. Sex and error-correction -- pt. 7. Information and mind.
  • 2006 Springer
    Donald R. Forsdyke.
    Also available: Print – 2006
  • 2008 Springer
    edited by Pierre Pontarotti.
    I. Modelization of Evolution -- Rate of Adaptation of Large Populations / Feng Yu and Alison Etheridge, p. 3-27 -- A Phylogenetic Mixture Model for Heterotachy / Andrew Meade and Mark Pagel, p. 29-41 -- II. Concepts in Evolutionary Biology -- Accelerated Evolution of Genes of Recent Origin / Macarena Toll-Riera, Jose Castresana and M. Mar Albà, p. 45-59 -- Life-Cycle Features of Tumour Cells / Jekaterina Erenpreisa and Mark S. Cragg, 61-71 -- General Evolutionary Regularities of Organic and Social Life / Valeria I. Mikhalevich, p. 73-94 -- Old and New Concepts in EvoDevo / Margherita Raineri, p. 95-114 -- III. Knowledge -- Overturning the Prejudices about Hydra and Metazoan Evolution / Hiroshi Shimizu, p. 117-134 -- The Search for the Origin of Cnidarian Nematocysts in Dinoflagellates / Jung Shan Hwang, Satoshi Nagai, Shiho Hayakawa, Yasuharu Takaku and Takashi Gojobori, p. 135-152 -- IV. Applied Evolutionary Biology -- A Possible Relationship Between the Phylogenetic Branch Lengths and the Chaetognath rRNA Paralog Gene Functionalities: Ubiquitous, Tissue-Specific or Pseudogenes / Roxane-Marie Barthélémy, Michel Grino, Pierre Pontarotti, Jean-Paul Casanova and Eric Faure, p. 155-164 -- Mode and Tempo of matK : Gene Evolution and Phylogenetic Implications / Khidir W. Hilu and Michelle M. Barthet, p. 165-179 -- Phylogeography and Conservation of the Rare South African Fruit Chafer Ichnestoma stobbiai (Coleoptera: Scarabaeidae) / Ute Kryger and Clarke H. Scholtz, p. 181-196 -- Nothing in Medicine Makes Sense Except in the Light of Evolution: A Review / Bernard Swynghedauw, p. 197-207 -- An Overview of Evolutionary Biology Concepts for Functional Annotation: Advances and Challenges / Anthony Levasseur and Pierre Pontarotti, p. 209-215.
  • 2008 Springer
    Elena Marchiori, Jason H. Moore (eds.).
  • 2007 Springer
    Elena Marchiori, Jason H. Moore, Jagath C. Rajapakse (eds.).
  • 2010
    David Goode.
    I demonstrate how comparative sequence analysis facilitates genome-wide base-pair level interpretation of individual genetic variation, and address three questions of importance for human personal genomics: First, whether an individual's functional variation comes mostly from noncoding or coding polymorphisms; second, whether population-specific or globally present polymorphisms contribute more to functional variation in any given individual; third what is the functional impact of short insertions and deletions in an individual genome. These questions have not been definitively answered by analyses of existing variation data because of a focus on coding polymorphisms, ascertainment biases in favor of common variation, and a lack of base-pair level resolution for identifying functional variants. The data set used in this study consisted of 575 amplicons resequenced in 432 individuals at genomic sites enriched for evolutionary constraint, and variation from 5 published human genomes. Single-site measures of evolutionary constraint derived from mammalian multiple sequence alignments are strongly predictive of reductions in modern-day genetic diversity across a range of annotation categories and across the allele frequency spectrum. I show that putatively functional variation in an individual genome is dominated by polymorphisms that do not change protein sequence, and which originate from our shared ancestral population and commonly segregate in human populations. Furthermore, I demonstrate that selection against short human indels has been shaped by patterns of evolutionary constraint, belying their potential functional importance. These observations show that common, noncoding alleles contribute substantially to human phenotypes and that constraint-based analyses will be of tremendous value to identify phenotypically-relevant variants in individual genomes.
  • 2006
    Gregory Michael Cooper.
    Status: Not Checked OutLane Catalog Record
  • 2012 Springer Protocols
    Fulltext v. 2 (2012) Springer Protocols
    edited by Maria Anisimova.
    Vol. 1. -- pt. I. Introduction: Bioinformactician's primers: 1. Introduction to genome biology: features, processes, and structures / Aidan Budd ; 2. Diversity of genome organisation / Aidan Budd ; 3. Probability, statistics, and computational science / Niko Beerenwinkel and Juliane Siebourg ; 4. The essentials of computational molecular evolution / Stéphane Aris-Brosou and Nicolas Rodrigue ; -- pt. II. Genomic data assembly, alignment, and homology inference: 5. Next-generation sequencing technologies and fragment assembly algorithms / Heewook Lee and Haixu Tang ; 6. Gene prediction / Tyler Alioto ; 7. Alignment methods: strategies, challenges, benchmarking, and comparative overview / Ari Lötynoja ; 8. Whole-genome alignment / Colin N. Dewey ; 9. Inferring orthology and paralogy / Adrian M. Altenhoff and Christophe Dessimoz ; 10. Detecting laterally transferred genes / Rajeev K. Azad and Jeffrey G. Lawrence ; -- pt. III. Genome evolution: insights from statistical analyses: 11. Genome evolution in outcrossing versus selfing versus asexual species / Sylvain Glémin and Nicolas Galtier ; 12. Transposable elements and their identification / Wojciech Makałowski, Amit Pande, Valer Gotea, and Izabela Makałowska ; 13. Evolution of genome content: population dynamics of transposable elements in flies and humans / Josefa González and Dmitri Petrov ; 14. Detection and phylogenetic assessment of conserved synteny derived from whole genome duplications / Shigehiro Kuraku and Axel Meyer ; 15. Analysis of gene order evolution beyond single-copy genes / Nadia El-Mabrouk and David Sankoff ; 16. Discovering patterns in gene order / Laxmi Parida and Niina Haiminen -- Vol. 2. -- pt. I. Phylogenomics: 1. Tangled trees: the challenge of inferring species trees from coalescent and noncoalescent genes / Christian N.K. Anderson, Liang Liu, Dennis Pearl, and Scott V. Edwards ; 2. Modeling gene family evolution and reconciling phylogenetic discord / Gergely J. Szöllősi and Vincent Daubin ; 3. Genome-wide comparative analysis comparative analysis of phylogenetic trees: the Prokaryotic forest of life / Pere Puigbó, Yuri I. Wolf, and Eugene V. Koonin ; 4. Philosophy and evolution: minding the gap between evolutionary patterns and tree-like patterns / Eric Bapteste, Frédéric Bouchard, and Richard M. Burian ; -- pt. II. Natural selection, recombination, and innovation in genomic sequences: 5. Selection on the protein-coding genome / Carolin Kosiol and Maria Anisimova ; 6. Methods to detect selection on noncoding DNA / Ying Zhen and Peter Andolfatto ; 7. The origin and evolution of new genes / Margarida Cardoso-Moreiera and Manyuan Long ; 8. Evolution of protein domain architectures / Kristoffer Forslund and Erik L.L. Sonnhammer ; 9. Estimating recombination rates from genetic variation in humans / Adam Auton and Gil McVean ; 10. Evolution of viral genomes: interplay between selection, recombination and other forces / Sergei L. Kosakovsky Pond, Ben Murrell, and Art F.Y. Poon ; -- pt. III. Population genomics: 11. Association mapping and disease: evolutionary perspectives / Soren Besenbacher, Thomas Mailund, and Mikkel H. Schierup ; 12. Ancestral population genomics / Julien Y. Dutheil and Asger Hobolth ; 13. Nonredundant representation of ancestral recombinations graphs / Laxmi Parida ; -- pt. IV: The "-OMICS". 14. Using Genomic tools to study regulatory evolution / Yoav Gilad ; 15. Characterization and evolutionary analysis of protein-protein interaction networks / Gabriel Musso, Andrew Emili, and Zhaolei Zhang ; 16. Statistical methods in metabolomics / Alexander Korman, Amy Oh, Alexander Raskind, and David Banks ; 17. Introduction the analysis of environmental sequences: metagenomics with MEGAN / Daniel H. Huson and Suparna Mitra ; 18. Analyzing epigenome data in context of genome evolution and human diseases / Lars Feuerbach, Konstantin Halachev, Yassen Assenov, Fabian Müller, Cahristoph Bock, and Thomas Lengauer ; 19. Genetical genomics for evolutionary studies / Pjotr Prins, Geert Smant, and Ritsert C. Jansen ; -- pt. V. Handling genomic data: resources and computation: 20. Genomics data resources: frameworks and standards / Mark D. Wilkinson ; 21. Sharing programming resources between bio* projects through remote procedure call and native call stack strategies / Pjotr Prins, Naohisa Goto, Andrew Yates, Laurent Gautier, Scotter Willis, Christopher Fields, and Toshiaki Katayama ; 22. Scaleable computing for evoluntionart genomics / Pjotr Prins, Dominique Belhachemi, Steffen Möller, and Geert Smant.
  • 2012 Springer
    Orkun S. Soyer, editor.
    Also available: Print – 2012
  • 2016 Springer
    Alexandra Alvergne, Crispin Jenkinson, Charlotte Faurie, editors.
    Preface -- Chapter 1: Applying evolutionary thinking in medicine: an introduction -- Chapter 2: "Foetal-maternal conflicts" and adverse outcomes in human pregnancies -- Chapter 3: Obstructed labour: the classic obstetric dilemma and beyond -- Chapter 4: Bottle feeding: the impact on postpartum depression, birth spacing and autism -- Chapter 5: Sudden Infant Death Syndrome -- Chapter 6: The Developmental Origins of Health and Disease: adaptation reconsidered -- Chapter 7: Is calculus relevant to survival? Managing the evolutionary novelty of modern education -- Chapter 8: Binge eating, Disinhibition and obesity -- Chapter 9: Evolutionary aspects of the dietary omega-6/omega-3 fatty acid ratio: medical implications -- Chapter 10: Evolutionary paradigms in cardiology: the case of chronic heart failure -- Chapter 11: Evolutionary imprints on cardiovascular physiology and pathophysiology -- Chapter 12: Darwinian Strategies to Avoid the Evolution of Drug Resistance During Cancer Treatment -- Chapter 13: Why chemotherapy does not work: cancer genome evolution and the illusion of oncogene addiction -- Chapter 14: Evolution, Infection, and Cancer -- Chapter 15: Microbes, Parasites and Immune diseases -- Chapter 16: Evolutionary principles and Host Defense -- Chapter 17: Helminth immunoregulation and Multiple Sclerosis treatment -- Chapter 18: Inflammaging and its role in ageing and age-related diseases -- Chapter 19: Dementias of the Alzheimer type: views through the lens of evolutionary biology suggest amyloid-driven brain aging is balanced against host defence -- Chapter 20: The Evolutionary Etiologies of Autism Spectrum and Psychotic-Affective Spectrum Disorders -- Chapter 21: Why are humans vulnerable to Alzheimer's Disease? -- Chapter 22: Evolutionary approaches to depression: prospects and limitations -- Chapter 23: The ups and downs of placebos. .
  • 2007 Springer
    by C.H. Vanderwolf.
  • 2002 HighWire
    Also available: Print – 2002
  • 2004 HighWire
    edited by Peter Meredith, Karl Swedberg.
    Also available: Print – 2004
  • 2012 WHO
    Chapter 1. The evolving threat of antimicrobial resistance: Introduction -- Chapter 2. Surveillance to track antimicrobial use and resistance in bacteria -- Chapter 3. Measures to ensure better use of antibiotics -- Chapter 4. Reducing antimicrobial use in animal husbandry -- Chapter 5. Infection prevention and control in health-care facilities -- Chapter 6. Fostering innovation to combat antimicrobial resistance -- Chapter 7. The way forward: political commitment to enable options for action -- Appendix 1. List of 2001 WHO Global Strategy for Containment of Antimicrobial Resistance recommendations -- Appendix 2. List of 2011 WHO World Health Day six-point policy briefs.
    Also available: Print – 2012
  • 2005 CRCnetBASE
    Cazes, Jack; Ewing, Galen Wood.
  • 2007
    guest editors: Stephen I. Rennard, Tim Higenbottam.
  • Examination preparation and subject review for USMLE Step 1 (9000+ questions), USMLE Step 2 (5000+ questions), and USMLE Step 3 (3000+ questions), among others. Certification Review aids cover Family Practice, General Pediatrics, General Surgery, Internal Medicine, Obstetrics and Gynecology, and SPEX. Students can create self-study exams in a variety of subjects.
  • 2015 Thieme eNeurosurgery
    2015 Thieme-Connect
    Stephen Russell.
    "This book teaches the reader how to properly examine a patient with a suspected focal neuropathy. This instruction includes the pertinent anatomy of each peripheral nerve, clear photographs illustrating the muscular examination, and also discussion on how to approach localization and diagnosis. Because a strong foundation in anatomical relationships is paramount for examining patients with nerve injury, this is stressed in the text and by using numerous illustrations." --Excerpt from notes provided by publisher.
  • 2014 Cambridge
    edited by Nick Harris, Fazal Ali.
  • 2012
    Jacqueline Leigh Grant.
    [Beta]-amyloid-42 (A[beta]42) and [beta]-amyloid-40 (A[beta]40), major components of senile plaque deposits in Alzheimer's disease (AD), are considered neurotoxic and pro-inflammatory. In Multiple Sclerosis (MS), A[beta]42 is upregulated in brain lesions and damaged axons. Here we found, unexpectedly, that treatment with either A[beta]42 or A[beta]40 peptides reduced motor paralysis and brain inflammation in four different models of experimental autoimmune encephalomyelitis (EAE) with attenuation of motor paralysis, reduction of inflammatory lesions in the central nervous system (CNS), and suppression of lymphocyte activation. A[beta]42 and A[beta]40 treatments were effective in reducing ongoing paralysis induced with adoptive transfer of either autoreactive Th1 or Th17 cells. High-dimensional 14-parameter flow cytometry of peripheral immune cell populations after in vivo A[beta]2 and A[beta]40 treatment revealed substantial modulations in the percentage of lymphoid and myeloid subsets during EAE. Major pro-inflammatory cytokines and chemokines were reduced in the blood following A[beta] peptide treatment. Protection conferred by A[beta] treatment did not require its delivery to the brain: adoptive transfer with lymphocytes from donors treated with A[beta]42 attenuated EAE in WT recipient mice and A[beta] deposition in the brain was not detected in treated EAE mice by immunohistochemical analysis. In contrast to the improvement in EAE with A[beta]-treatment, EAE was worse in mice with genetic deletion of the amyloid precursor protein. Therefore, in the absence of A[beta] there is exacerbated clinical EAE disease progression. Since A[beta]42 and A[beta]40 ameliorate experimental autoimmune inflammation targeting the CNS, we might now consider its potential anti-inflammatory role in other neuropathological conditions.
  • 2009 ebrary
    Susan M. Reverby.
    Introduction: Race, medical uncertainty, and American culture -- Part. I. Testimony -- 1. Historical contingencies: Tuskegee Institute, the Public Health Service, and syphilis -- 2. Planned, plotted, & official: the study begins -- 3. Almost undone: the study continues -- 4. What makes it stop? -- 5. Testimony: the public story in the 1970s -- Part II. Testifying -- 6. What happened to the men & their families? -- 7. Why & wherefore: the Public Health Service doctors -- 8. Triage & "powerful sympathizing": Eugene H. Dibble, Jr. -- 9. The Best care: Eunice Verdell Rivers Laurie -- Part III. Traveling -- 10. Bioethics, history, & the study as gospel -- 11. The Court of imagination -- 12. The Political spectacle of blame & apology -- Epilogue: the difficulties of treating racism with "Tuskegee" -- Appendix A. Chronology -- Appendix B. Key participants' names -- Appendix C. Men's names -- Appendix D. Tables and charts
  • [v.1], 2014
    Jonathan Orsay.
    Status: Not Checked OutLane Catalog Record
  • [v.2], 2014
    Jonathan Orsay.
    Status: Not Checked OutLane Catalog Record
  • [v.3], 2014
    Jonathan Orsay.
    Status: Not Checked OutLane Catalog Record
  • [v.4], 2014
    Jonathan Orsay.
    Status: Not Checked OutLane Catalog Record
  • [v.5], 2014
    Jonathan Orsay.
    Status: Not Checked OutLane Catalog Record
  • [v.6], 2014
    Jonathan Orsay.
    Status: Not Checked OutLane Catalog Record
  • 2007 ProQuest Safari
    John Walkenbach.
    Getting Started with Excel -- Introducing Excel -- What's New in Excel 2007? -- Entering and Editing Worksheet Data -- Essential Worksheet Operations -- Working with Cells and Ranges -- Introducing tables -- Worksheet Formatting -- Understanding Excel's Files -- Using and Creating Templates -- Printing Your Work -- Working with Formulas and Functions -- Introducing Formulas and Functions -- Creating Formulas and Functions -- Creating Formulas That Manipulate Text -- Working with Dates and Times -- Creating Formulas That Count and Sum -- Creating Formulas That Look Up Values -- Creating Formulas for Financial Applications -- Introducing Array Formulas -- Performing Magic with Array Formulas -- Creating Charts and Graphics -- Getting Started Making Charts -- Learning Advanced Charting -- Visualizing Data Using Conditional Formatting -- Enhancing Your Work with Pictures and Drawings -- Using Advanced Excel Features -- Customizing the Quick Access Toolbar -- Using Custom Number Formats -- Using Data Validation -- Creating and Using Worksheet Outlines -- Linking and Consolidating Worksheets -- Excel and the Internet -- Sharing Data with Other Applications -- Using Excel in a Workgroup -- Protecting Your Work -- Making Your Worksheets Error-Free -- Analyzing Data with Excel -- Using Microsoft Query with External Database Files -- Introducing Pivot Tables -- Analyzing Data with Pivot Tables -- Performing Spreadsheet What-If Analysis -- Analyzing Data Using Goal Seek and Solver -- Analyzing Data with the Analysis Tookpak -- Programming Excel with VBA -- Introducing Visual Basic for Applications -- Creating Custom Worksheet Functions -- Creating UserForms -- Using UserForm Controls in a Worksheet -- Working with Excel Events -- VGA Examples -- Creating Custom Excel Add-Ins -- Worksheet Function Reference -- What's on the CD-ROM -- Additional Excel Resources -- Excel Shortcut Keys.
    Also available: Print – 2007
  • 2007
    E. Joseph Billo.
    Status: Not Checked OutLane Catalog Record
  • 2007 ProQuest Safari
    David and Raina Hawley.
    Reducing workbook and worksheet frustration -- Hacking Excel's built-in features -- Naming hacks -- Hacking PivotTables -- Hacking formulas and functions -- Macro hacks -- Cross-application hacks.
  • 2006
    David M. Bourg.
    Status: Not Checked OutLane Catalog Record
    Using Excel -- Getting acquainted with Visual Basic for Applications -- Collecting and cleaning up data -- Charting -- Statistical analysis -- Time series analysis -- Mathematical functions -- Curve fitting and regression -- Solving equations -- Numerical integration and differentiation -- Solving ordinary differential equations -- Solving partial differential equations -- Performing optimization analyses in Excel -- Introduction to financial calculations.
  • 2016 Karger
    volume editor, Tetsuo Himi, Kenichi Takano.
    Clinical review of cochlear implantation performed at Sapporo Medical University Hospital / Ogasawara, N., Takano, K., Shintani, T., Saikawa, E., Takahashi, N., Ito, F., Himi, T. -- Cochlear implantation in children with cochlear malformation / Saikawa, E., Takano, K., Ogasawara, N., Tsubomatsu, C., Takahashi, N., Shirasaki, H., Himi, T. -- Congenital microtia treated at Sapporo Medical University Hospital : clinical characteristics and associated anomalies / Ogasawara, N., Jitsukawa, S., Takahashi, N., Takano, K., Himi, T. -- Influence of age on caloric response / Jitsukawa, S., Takano, K., Ito, F., Tsubomatsu, C., Himi, T. -- Pneumolabyrinth with labyrinthitis as the suspected cause / Nomura, K., Takano, K., Yamamoto, K., Abe, A., Takahashi, N., Okuni, T., Himi, T. -- Behavior of primary cilia and tricellular tight junction proteins during differentiation in temperature-sensitive mouse cochlear precursor hair cells / Kakuki, T., Kaneko, Y., Takano, K., Ninomiya, T., Kohno, T., Kojima, T., Himi, T. -- Relationship between otitis media and epithelial function in the lymphoepithelium of pediatric adenoids / Ogasawara, N., Yamamoto, K., Takano, K., Himi, T. -- Role of cysteinyl leukotrienes in allergic rhinitis / Shirasaki, H., Himi, T. -- Radiological assessment of the anatomy of frontal recess cells and the Anterior ethmoidal artery / Okuni, T., Takano, K., Nomura, K., Yamashita, K., Abe, A., Ito, F., Murayama, K., Shirasaki, H., Himi, T. -- Nasal mucosal expression of the receptors for inflammatory chemical mediators / Shirasaki, H., Kanaizumi, E., Seki, N., Kikuchi, M., Himi, T. -- Adenovirus-mediated ICOSIg gene therapy in a presensitized murine model of allergic rhinitis / Sato, J., Konno, N., Murakami, M., Uede, T., Himi, T. -- A Novel drug delivery system for the human nasal epithelium / Takano, K., Kojima, T., Keira, T., Miyata, R., Nomura, K., Kakuki, T., Kaneko, Y., Yajima, R., Kakiuchi, A., Himi, T. -- Role of crosstalk between epithelial and Immune cells, the epimmunome, in allergic rhinitis pathogenesis / Kamekura, R., Yamashita, K., Jitsukawa, S., Nagaya, T., Ito, F., Ichimiya, S., Himi, T. -- A clinical study of maxillary sinus squamous cell carcinoma / Kondo, A., Kurose, M., Obata, K., Yamamoto, K., Murayama, K., Shirasaki, H., Himi, T. -- A clinical review of thyroid cancer at Sapporo Medical University Hospital / Koizumi, J., Takano, K., Obata, K., Yamamoto, K., Murayama, K., Himi, T. -- Junctional Adhesion Molecule-A in Head and Neck Squamous Cell Carcinoma / Kurose, M., Kakuki, T., Takano, K., Kondo, A., Obata, K., Nomura, K., Miyata, R., Kaneko, Y., Konno, T., Kohno, T., Kojima, T., Himi, T. -- Expression of inflammasome-associated proteins in human oropharyngeal squamous cell carcinoma / Takano, K., Kondo, A., Kurose, M., Yamashita, K., Nomura, K., Obata, K., Murayama, K., Ito, F., Himi, T. -- Diagnosis and treatment of obstructive sleep apnea syndrome in children / Tsubomatsu, C., Abe, A., Yajima, R., Takahashi, N., Ito, F., Takano, K., Himi, T. -- Expression and localization of human defensins in palatine tonsils / Kamekura, R., Imai, R., Takano, K., Yamashita, K., Jitsukawa, S., Nagaya, T., Ito, F., Hirao, M., Tsubota, H., Himi, T. -- Studies of tonsils in basic and clinical perspectives : from the past to the future / Yamashita, K., Ichimiya, S., Kamekura, R., Nagaya, T., Jitsukawa, S., Matsumiya, H., Takano, K., Himi, T. -- A case study of anisakiasis in the palatine tonsils / Takano, K., Okuni, T., Murayama, K., Himi, T.
  • v. 1-2, 1967-71.
    [Jerome Hellmuth, editor].
    Status: Not Checked OutLane Catalog Record
    v. 1. The Normal infant.--v. 2. Studies in abnormalities.--v. 3. Assessment & intervention.
  • 2012 ScienceDirect
    edited by Jac Andrews, Peter Istvanffy.
    Most students in training to become teachers, psychologists, physicians, and social workers as well as many practicing professionals in these disciplines do not get the opportunity to fully understand and appreciate the circumstances of children ,parents, and teachers who have had to cope and adapt to childhood disorder. Most professionals in the field of childhood disorders are well trained in assessment and treatment methods and are aware of the clinical, theoretical, and empirical foundations of the work they do. In their training, they get some experience in diagnosing the educational, psychological, social, and medical problems of children through their supervised clinical internships. In their training and in their professional practice they get to interview, discuss, consult and collaborate with children and their families regarding developmental issues and treatment plans, however, they rarely get an opportunity to fully realize and understand what it is like to have a disorder and what it is like to be a mother, or father, or teacher of children with disorders. This book provides an opportunity for students in training and professionals in the field to gain some awareness of the life journeys of some exceptional children, their families and their teachers. Focuses on those childhood disorders that are most common or what are sometimes referred to as high incidence disorders such as learning disabilities, autism, behavior disorder, depression, and anxiety Beyond, a clinical, empirical, and theoretical description of childhood disorders or a personal account relative to one particular disorder, this book provides rich narratives of experience from multiple perspectives with respect to numerous childhood disorders Provides readers with insight by sharing examples of personal contexts and situations, significant life issues, challenges and barriers, successes, and recommendations relative to particular circumstances.
  • 2012
    Cohen, Sheldon G.; Samter, Max.
    Status: Not Checked OutLane Catalog Record
    Antiquity -- 1190 to about 1889 -- 1890 to about 1910 -- 1911 to about 1940 -- 1941 to about 1969 -- 1970 to about 1987.
  • 2006 CRCnetBASE
    edited by Ashok Katdare, Mahesh V. Chaubal.
  • 2006 CRCnetBASE
    Theresa G. Di Maio, Vincent J.M. Di Maio.
    A suspect, prisoner, or psychiatric patient becomes violent. The officer or hospital staff struggle to control the person, sometimes with a choke hold or hog tying. Shortly afterward, the patient dies. This illustrates excited delirium syndrome, a condition in which normal physiological changes produced by violent activity culminate in sudden cardiac death. This book discusses the effects of both legal medication and drugs of abuse on the cardiovascular system. The authors also discuss the effects of underlying disease and prevention of the syndrome, the role of the mental health professional, and the "high-risk" individual.
  • 2012 Cambridge
    [edited by] Scott J. Hunter, Elizabeth P. Sparrow.
    "Executive dysfunction occurs in many clinical conditions and has significant impact on multiple facets of life. This book summarizes executive function and dysfunction for practitioners, researchers and educators, covering lifespan development, assessment, impact and interventions. Drawing together clinical, neurobiological and developmental viewpoints, the authors summarize the latest research findings in practical and applied terms, and review conceptual approaches to assessing and identifying executive function and dysfunction. Several chapters are devoted to practical aspects of executive dysfunction, including research-based treatment strategies, educational implications, forensic cautions and intervention resources. Executive dysfunction in ADHD, LD, MR, autism, mood disorders, epilepsy, cancer and TBI is covered, with test performance, neuroimaging and clinical presentation for these clinical conditions. The book concludes with anticipation of future work in the field. This is a key reference for medical, psychological and educational professionals who work with children, adolescents and young adults in clinical and educational settings"-- Provided by publisher.
  • 2010 Springer
    John Saxton, Amanda Delay, editors.
  • 2011 CRCnetBASE
    Brian C. Leutholtz, Ignacio Ripoll.
    Section 1. 'Postmodern' medicine : teaching patients to be responsible for their health -- section 2. Curing, healing, and maintaining health.
  • 2016 Springer
    Diana Vaamonde, Stefan S du Plessis, Ashok Agarwal, editors.
    Overview of the male reproductive system.- Overview of the female reproductive system.- Overview of Fertilization, Gestation and Parturition.- Conceptual and terminological foundations for the sciences of physical exercise: new perspectives.- Sports Physiology and Endocrinology (Endurance vs. Resistance Exercise).- General adaptations to exercise. Acute vs. chronic and strength vs. endurance training.- Impact of physical activity and exercise on male reproductive potential. Semen alterations.- Hormonal changes associated with physical activity and exercise training.- Common male reproductive tract pathologies associated with physical activity, exercise and sport.- Consequences of the Use of Anabolic Androgenic Steroids In Male Athletes' Fertility.- Impact of physical activity and exercise on female reproductive potential.- Hormonal and Reproductive Changes Associated with Physical Activity and Exercise.- Risk Biotypes and the Female Athlete Triad.- Consequences Of The Use Of Anabolic Androgenic Steroids On Female Athletes' Fertility.- Impact of intense physical activity on puberty and reproductive potential of young athletes.- Physical activity and pregnancy.- Impact of combined oral contraceptive use on exercise and health in female athletes.- Oxidative Stress and Infertility: a Possible Link to Exer cise.- Nutritional Deficiencies and Impairment of Fertility in Athletes -- Recommendations and therapeutic guidelines for exercise-related reproductive disorders -- Exercise strategies as therapeutic treatment for fertility disorders (obesity, PCOS, etc).
  • 2014 Springer
    Joost Dekker, editor.
    Osteoarthritis (OA) is among the top 10 of most disabling diseases in the Western world. It is the major cause of pain and disability among the elderly. This book provides a contextual review of recent research on neuromuscular factors and behavioral risk factors for functional decline in OA, with a special emphasis on explanatory mechanisms. In addition, the book discusses innovative approaches to exercise and physical activity in OA, derived from research on behavioral and neuromuscular risk factors for functional decline in OA. Recent research has shown that neuromuscular factors (such as muscle strength, joint laxity) and behavioral factors (such as avoidance of activity, depressed mood) predict pain and disability in OA. Furthermore, exercise and physical activity are among the dominant interventions aiming at reducing pain and disability, and innovative interventions targeting neuromuscular and behavioral interventions have been recently developed. This research has been published as separate papers, with the result that the field is in need of an integrative contextual review that puts the research into theoretical perspective.
  • 2006
    Victor F. Froelicher, Jonathan Myers.
    Status: Not Checked OutLane Catalog Record
  • 2012 Springer
    Michael S. Sagiv.
    1. Exercise Physiology -- 2. Pulmonary Function -- 3. Cardiac Output -- 4. Cardiac Output Redistribution -- 5. Left Ventricular Function -- 6. Blood Pressure and Hypertension -- 7. Metabolic Cardiovascular Risk Factors -- 8. Cardiopulmonary Function in Elderly -- 9. Exercise and Sudden Death -- 10. Cardiac Rehabilitation.
  • 2013 Springer
    Cornelia M. Ulrich, Karen Steindorf, Nathan A. Berger, editors.
    Although it is well established that the worldwide pandemic of overweight and obesity has profound effects on promoting cancer, it is now recognized that alternative aspects of energy balance, namely physical activity and exercise have significant beneficial effects on all aspects of cancer across the spectrum from prevention through treatment and extending through survivorship. While the effect of physical activity and exercise on cancer may be partially mediated through obesity control, it is clear that considerable research is required and is ongoing at both the molecular and clinical levels to better understand the associated mechanisms and to develop optimal exercise strategies. This volume presents the effects of exercise on biological pathways in tumor growth, state of the art exercise strategies and cutting edge research focused on different cancers and patient groups. This important text will provide a basis for ongoing research, experimental approaches and application of evidence based practices to clinical care for patients with cancer.
  • 2015 Springer
    edited by Gail M. Sullivan, Alice K. Pomidor.
  • 2011 Springer
    Linda S. Pescatello, Stephen M. Roth, editors.
    Fundamental Concepts in Exercise Genomics -- Statistical and Methodological Considerations in Exercise Genomics -- Can You Be Born a Couch Potato? The Genomic Regulation of Physical Activity -- Interaction Between Exercise and Genetics in Type 2 Diabetes Mellitus: An Epidemiological Perspective -- The Interaction Between Genetic Variation and Exercise and Physical Activity in the Determination of Body Composition and Obesity Status -- Interactive Effects of Genetics and Acute Exercise and Exercise Training on Plasma Lipoprotein-Lipid and Blood Pressure Phenotypes -- Genetic Aspects of Muscular Strength and Size -- Genomics of Aerobic Capacity and Endurance Performance: Clinical Implications -- A Synopsis of Exercise Genomics Research and a Vision for its Future Translation into Practice.
  • 2003 ScienceDirect
    edited by Charles M. Tipton.
    Ancient and early influences / Jack W. Berryman -- The neuromuscular system / Alan J. McComas -- The cardiovascular system / Loring B. Rowell -- The respiratory system / Jerome A. Dempsey and Brian J. Whipp -- The autonomic nervous system / Charles M. Tipton -- The oxygen transport system and maximal oxygen uptake / Jere H. Mitchell and Bengt Saltin -- The metabolic systems: aerobic metabolism and substrate utilization in exercising skeletal muscle / R. James Barnard and John O. Holloszy -- The metabolic systems: anaerobic metabolism (glycolytic and phosphagen) / George A. Brooks and L. Bruce Gladden -- The endocrine system: metabolic effects of the pancreatic, adrenal, thyroidal, and growth hormones / Michael C. Riddell ... [et al.] -- The temperature regulatory system / Elsworth R. Buskirk -- The renal system / Jacques R. Poortmans and Edward J. Zambraski -- The gastrointestinal system / Carl V. Gisolfi
  • 2009 Springer
    Corey H. Evans, Russell D. White, editors.
  • 2007 Springer
    Isao Ishikawa.
  • 2014 Springer Protocols
    edited by Andrei I. Ivanov.
    Pharmacological inhibitors of exocytosis and endocytosis: novel bullets for old targets -- Systematic analysis of endocytosis by cellular perturbations -- Real-time detection of SNARE complex assembly with FRET using the tetracysteine system -- Profiling lysine ubiquitination by selective enrichment of ubiquitin remnant-containing peptides -- Secretion of circular proteins using sortase -- Fractionation of subcellular membrane vesicles of epithelial and non-epithelial cells by OptiPrep density gradient ultracentrifugation -- Combining pulsed SILAC labeling and click-chemistry for quantitative secretome analysis -- Probabilistic density maps to study the spatial organization of endocytosis -- Use of Kaede and Kikume green-red fusions for live cell imaging of g protein-coupled receptors -- HaloTag as a tool to investigate peroxisome dynamics in cultured mammalian cells -- SNAP-tag to monitor trafficking of membrane proteins in polarized epithelial cells -- FlAsh-palm: Super-resolution pointillist imaging with FlAsh-tetracysteine labeling -- Analysis of protein dynamics with tandem fluorescent protein timers -- Synchronization of secretory cargos trafficking in populations of cells -- Use of transmembrane fret to investigate the internalization of glycosylated proteins -- A method to rapidly induce organelle-specific molecular activities and membrane tethering -- A novel pair of split Venus fragments to detect protein-protein interactions by in vitro and in vivo bimolecular fluorescence complementation assays -- Real-time investigation of plasma membrane deformation and fusion pore expansion using polarized total internal reflection fluorescence microscopy -- Nanocones to study initial steps of endocytosis -- A novel permeabilization protocol to obtain intracellular 3d immunolabeling for electron tomography -- VIS2FIX: Rapid chemical fixation of vitreous sections for immuno-electron microscopy -- Chemical genomics: Characterizing target pathways for bioactive compounds using the endomembrane trafficking network -- Application of RNAi technology and fluorescent protein markers to study membrane traffic in c. Elegans -- Visualization of clathrin-mediated endocytosis in live drosophila egg chambers -- A novel extraction protocol to probe the role of cholesterol in synaptic vesicle recycling -- Microfluidic devices for imaging trafficking events in vivo using genetic model organisms -- The "in situ" proximity ligation assay to probe protein-protein interactions in intact tissues -- Probing the role of the actin cytoskeleton during regulated exocytosis by intravital microscopy -- Measurement of dynamic F-actin changes during exocytosis.
  • 2008 Springer Protocols
    [edited by] Andrei I. Ivanov.
    Vesicular trafficking : molecular tools and targets / Elena V. Vassilieva and Asma Nusrat -- Pharmacological inhibition of endocytic pathways : is it specific enough to be useful? / Andrei I. Ivanov -- In vitro assays to measure SNARE-mediated vesicle fusion / Susanne Kreye, Jörg Malsam, and Thomas H. Söllner -- Imaging Ca²⁺-triggered exocytosis of single secretory granules on plasma membrane lawns from neuroendocrine cells / Thorsten Lang -- FRAP analysis of secretory granule lipids and proteins in the sea urchin egg / Julian L. Wong and Gary M. Wessel -- A cell-free assay for endocytosis of E-cadherin / Toshiaki Sakisaka and Yoshimi Takai -- Cell-surface biotinylation to study endocytosis and recycling of occludin / Noriyuki Nishimura and Takuya Sasaki -- Fractionation of subcellular membrane vesicles of epithelial and nonepithelial cells by OptiPrep density gradient / Xuhang Li and Mark Donowitz -- Identification and characterization of interacting partners of Rab GTPases by yeast two-hybrid analyses / Mark Kail and Angelika Barnekow -- High-throughput analysis of the dynamics of recycling cell surface proteins / Roland Glovers, David E. James, and Adelle C.F. Coster -- Studying phagocytosis by live-cell scintillation proximity assay / Walter Stockinger and Axel Nohturfft -- Transcytosis of polymeric immunoglobin A in polarized Madin-Darby canine kidney cells / Asli Oztan, Christine Rondanino, and Gerard Apodaca -- The use of syntaxin chimeras to study polarized protein trafficking in epithelial cells / Martin B.A. ter Beest -- Targeting the epithelial SNARE machinery by bacterial neurotoxins / Véronique Proux-Gillardeaux and Thierry Galli -- Endocytosis of endothelial cells is regulated by N-ethylmaleimide-sensitive factor / Munekazu Yamakuchi ... [et al.] -- Molecular dissection of HCL secretion in gastric parietal cells using streptolysin O permeabilization / Xia Ding .. [et al.] -- Addressing membrane protein topology using the fluorescence protease protection (FPP) assay / Holger Lorenz, Dale W. Hailey, and Jennifer Lippincott-Schwartz -- Visualizing clathrin-mediated IgE receptor internalization by electron and atomic force microscopy / Alan R. Burns ... [et al.] -- Analyzing endosomes in nonsectioned cells by transmission electron microscopy / Willem Stoorvogel -- Imaging exocytosis of single insulin secretory granules with TIRF microscopy / Shinya Nagamatsu and Mica Ohara-Imaizumi -- Reconstitution of depolarization and Ca²⁺-evoked secretion in Xenopus oocytes monitored by membrane capacitance / Roy Cohen, Bernhard M. Schmitt, and Daphne Atlas -- Low-noise recording of single-vesicle capacitance steps in cell-attached patches / Vitaly Klyachko, Zhenjie Zhang, and Meyer Jackson -- Good practices in single-cell amperometry / David J. Machado, Mónica S. Montesinos, and Ricardo Borges -- Analysis of single-vesicle exocytotic events recorded by amperometry / Eugene V. Mosharov -- Application of RNAi technology and fluorescent protein markers to study membrane traffic in Caenorhabditis elegans / Dmitry Poteryaev and Anne Spang -- FM 1-43 labeling of synaptic vesicle pools at the Drosophila neuromuscular junction / Patrik Verstreken, Tomoko Ohyama, and Hugo J. Bellen -- Probing E-cadherin endocytosis by morpholino-mediated Rab5 knockdown in zebrafish / Florian Ulrich and Carl-Philipp Heisenberg -- Quantifying endocytosis in vivo using intravital two-photon microscopy / Ruben M. Sandoval and Bruce A. Molitoris.
  • 2006
    Stephen Hunt.
    Status: Not Checked OutLane Catalog Record
  • 2014 Springer Protocols
    edited by Peter Thorn, School of Biomedical Sciences, University of Queensland, St. Lucia, QLD, Australia.
    Part I. Techniques in the Measurement of Exocytosis -- Solution Single-Vesicle Fusion Assay by Single-Molecule Alternating-Laser Excitation / Jae-Yeol Kim, Bong-Kyu Choi, Yeon-Kyun Shin, and Nam Ki Lee -- Imaging the Stages of Exocytosis in Epithelial Type II Pneumocytes / Thomas Haller and Paul Dietl -- Carbon-Fiber Amperometry in the Study of Exocytosis / Michael D. Duffield, Ravinarayan Raghupathi, and Damien J. Keating -- Imaging of Insulin Exocytosis from Pancreatic Beta Cells / Mica Ohara-Imaizumi, Kyota Aoyagi, and Shinya Nagamatsu -- Functional, Quantitative, and Super-Resolution Imaging and Spectroscopic Approaches for Studying Exocytosis / Rory R. Duncan and Colin Rickman -- Electrophysiologic Measurements of Membrane Capacitance in Hormone-Secreting Cells / Boštjan Rituper and Robert Zorec. Part II. Model Systems for the Study of Exocytosis -- Measuring Exocytosis in Endocrine Tissue Slices / Maša Skelin Klemen, Jurij Dolenšek, Andraž Stožer, and Marjan Slak Rupnik -- Intravital Microscopy and Its Application to Study Regulated Exocytosis in the Exocrine Glands of Live Rodents / Oleg Milberg, Natalie Porat-Shliom, Muhibullah Tora, Laura Parente, Andrius Masedunskas, and Roberto Weigert -- Rapid Analysis of Synaptic Vesicle Endocytosis in Synaptosomes / James A. Daniel and Phillip J. Robinson -- Isolated Neurohypophysial Terminals: Model for Depolarization-Secretion Coupling / José R. Lemos, James McNally, Edward Custer, Adolfo Cuadra, Hector Marrero, and Dixon Woodbury -- The Sea Urchin Egg and Cortical Vesicles as Model Systems to Dissect the Fast, Ca²-Triggered Steps of Regulated Exocytosis / Prabhodh S. Abbineni, Elise P. Wright, Tatiana P. Rogasevskaia, Murray C. Killingsworth, Chandra S. Malladi, and Jens R. Coorssen.
  • 2013
    Melissa Gale Works.
    Stroke is the fourth leading cause of death in industrialized countries and is a major cause of disability in the United States. Protein therapy shows promise for the reduction of brain damage following stroke; however, current delivery methods lack the ability to efficiently deliver therapeutic proteins to the brain without invasive methods. It is possible to exploit normal inflammation in the brain, and the resultant immune cell migration following stroke, by injecting modified leukocytes such as dendritic cells that act as carriers of protective transgenes in a non-invasive, ischemia-targeted manner. With this solution in mind, my thesis focused on investigating the mechanisms of ex vivo-derived dendritic cell (exDC) migration to the stroke brain and using exDCs as vehicles for the delivery of anti-inflammatory proteins. I determined that the number of exDCs that migrate to the brain after stroke is positively correlated with the level of inflammation 6 hour after stroke. Tissue damage is also positively correlated with inflammation at this same time point. Finally, I investigated whether exDCs could be modified to deliver anti-inflammatory therapy after stroke. ExDCs were successfully transduced to constitutively express soluble TNF receptor 1 (sTNFR1) secrete functional protein that does not alter the phenotype or migratory ability of the cells. Importantly, when sTNFR1-exDCs are delivered after stroke they reduce inflammation and damage in vivo. These studies indicate that the use of cell-mediated protein delivery may be a promising new approach to reduce brain damage following acute neurological insult.
  • 2012 Springer Protocols
    edited by Annemieke Aartsma-Rus.
    DNA diagnostics and exon skipping / Umasuthan Srirangalingam and Shern L. Chew -- Bioinformatics and mutations leading to exon skipping / F.O. Desmet and C. Béroud -- Minigenes to confirm exon skipping mutations / Lourdes R. Desviat, Belén Pérez, and Magdalena Ugarte -- Analysis and interpretation of RNA splicing alterations in genes involved in genetic disorders / Maaike P.G. Vreeswijk and Heleen M. van der Klift -- Exon skipping mutations in neurofibromatosis / Emanuele Buratti and Diana Baralle -- Overview on applications of antisense-mediated exon skipping / Willeke M.C. van Roon-Mom and Annemieke Aartsma-Rus -- Overview on DMD exon skipping / Annemieke Aartsma-Rus -- Overview on AON design / Annemieke Aartsma-Rus -- Optimizing RNA/ENA chimeric antisense oligonucleotides using in vitro splicing / Yasuhiro Takeshima, Mariko Yagi, and Masafumi Matsuo -- Optimizing antisense oligonucleotides using phophorodiamidate morpholino oligomers / Linda J. Popplewell, Alberto Malerba, and George Dickson -- Optimizing splice-switching oligomer sequences using 2'-O-methyl phosphorothioate chemistry / Carl Adkin, Sue Fletcher, and Steve D. Wilton -- Exon skipping quantification by real-time PCR / Alessandra Ferlini and Paola Rimessi -- Antisense-mediated exon skipping to shift alternative splicing to treat cancer / Jing Wan -- Antisense-mediated exon skipping to generate soluble receptors / A. Seda Yilmaz-Elis and J. Sjef Verbeek -- Antisense-mediated exon skipping to reframe transcripts / Sandrina Turczynski [and others] -- U1 snRNA as an effective vector for stable expression of antisense molecules and for the inhibition of the splicing reaction / Julie Martone, Fernanda Gabriella De Angelis, and Irene Bozzoni -- Engineering U7snRNA gene to reframe transcripts / Aurélie Goyenvalle -- Dynamic fluorescent and luminescent reporters for cell-based splicing screens / Claude C. Warzecha, Ruben Hovhannisyan, and Russ P. Carstens -- Antisense-mediated exon-skipping to induce gene knockdown / Petra Disterer and Bernard Khoo -- Antisense-mediated exon inclusion / Yimin Hua and Adrian R. Krainer -- Antisense genes to induce exon inclusion / Rachel Nlend Nlend and Daniel Schümperli -- Using mini-genes to identify factors that modulate alternative splicing / Robert Morse, Adrian G. Todd, and Philip J. Young -- Overview of alternative oligonucleotide chemistries for exon skipping / Amer F. Saleh, Andrey A. Arzumanov, and Michael J. Gait -- Identification of peptides for tissue-specific delivery / Hans Heemskerk -- Systemic delivery of antisense oligomer in animal models and its implications for treating DMD / Qi Long Lu and Bo Wu -- Cell-penetrating peptides enhance systemic delivery of antisense morpholino oligomers / Hong M. Moulton -- Optimizing tissue-specific antisense oligonucleotide-peptide conjugates / Corinne A. Betts [and others].
  • 2007 Springer
    volume editors, Jean-Pierre Verbelen, Kris Vissenberg.
  • 2005 Springer
    edited by Arthur W. Galston and Christiana Z. Peppard.
    The past, present and future of human nature / Samuel Gorovitz -- Unethical contexts for ethical questions / David Ehrenfeld -- Human subject protections: some thoughts on costs and benefits in the humanistic disciplines / C. Kristina Gunsalus -- Secret state experiments and medical ethics / Jonathan Moreno -- Cross-cultural considerations in medical ethics: the case of human subjects research / Marcia Angell -- Reproductive rights and health in the developing world / Ruth Macklin -- Genetic testing of human embryos: ethical challenges and policy choices / Kathy Hudson, Susannah Baruch & Gail Javitt -- Choosing our children: the uneasy alliance of law and ethics in John Robertson's thought / Karen Lebacqz -- The heart disease epidemic that wasn't: lessons learned from death certificate statistics / Harry M. Rosenberg -- Recent history of end-of-life care and implications for the future / James Flory & Ezekiel Emanuel -- The pragmatic power and promise of theoretical environmental ethics: forging a new discourse / J. Baird Callicott -- The expanding circle and moral community - naturally speaking / Chalmers Clark -- Science, conservation and global security / George M. Woodwell -- Energy, technology and climate: running out of gas / David Goodstein.
  • 2016 Springer
    Giovanni Stanghellini, Massimiliano Aragona, editors.
  • 2011 Springer
    Jeffrey Medin, Daniel Fowler, editors.
    T cell therapy: state-of-the-art -- Extending the use of adoptive T cell immunotherapy for infections and cancer -- Non-T cell therapeutic approaches -- B lymphocytes in cancer immunology -- Monoclonal antibody therapy for cancer -- Natural killer cells for cancer immunotherapy -- Dendritic cell-based cancer vaccines: practical considerations -- Mesenchymal stromal cells: an emerging cell-based pharmaceutical -- T cell therapeutic approaches -- Tumor-specific mutations as targets for cancer immunotherapy -- Counteracting subversion of MHC class II antigen presentation by tumors -- Mechanisms and implications of immunodominance in CD8⁺ T-cell responses -- T regulatory cells and cancer immunotherapy -- Negative regulators in cancer immunology and immunotherapy -- Genetically engineered antigen specificity in T cells for adoptive immunotherapy -- Non-cellular aspects of cancer immunotherapy -- Cytokine immunotherapy -- Transcriptional modulation using histone deacetylase inhibitors for cancer immunotherapy -- Combining cancer vaccines with conventional therapies -- Combining oncolytic viruses with cancer immunotherapy -- Radiation therapy and cancer treatment: from the basics to combination therapies that ignite immunity -- Assessing immunotherapy through cellular and molecular imaging -- Transplantation -- Allogeneic and autologous transplantation therapy of cancer: converging themes.
  • 2013 Springer
    Julia V. Burnier, Miguel N. Burnier, Jr., editors.
    The primary cause of death related to cancers can be traced back to metastases, originated from cancer cells. The presence of metastatic disease, the spread of cancer cells, is the most important prognostic and survival factor in patients with cancer. Although treatment of the primary tumor is well established and usually results in local control, treating metastatic disease is a much more daunting task. At diagnosis, few patients present with clinically detectable metastatic lesions regardless of the clinical prognostic factor. Clinical trials assessing potential therapeutic agents are important in order to define the best specific treatment for a particular patient, which are the basis for patient-oriented research that eventually lead to personalized medicine.This volume aims to comprehensively present the latest research and information about metastasis. Understanding the mechanisms underlying the metastatic phenomenon could have vast implications for the large number of patients who are at a high risk for the development of metastasis.
  • 2006
    Mark Alexander Engelhardt.
    Status: Not Checked OutLane Catalog Record
  • 2010 Karger
    volume editors, H.-P. Hammes, M. Porta.
    Clinical presentations and pathological correlates of retinopathy / T. Bek -- Retinal vascular permeability in health and disease / V. Poulaki -- In vivo models of diabetic retinopathy / L. Zheng, T.S. Kern -- Pericyte loss in the diabetic retina / F. Pfister, J. Lin, H.-P. Hammes -- Neuroglia in the diabetic retina / A. Bringmann, A. Reichenbach -- Regulatory and pathogenic roles of Müller glial cells in retinal neovascular processes and their potential for retinal regeneration / G.A. Limb, H. Jayaram -- Growth factors in the diabetic eye / R. Simó, C. Hernández -- Balance between pigment epithelium-derived factor and vascular endothelial growth factor in diabetic retinopathy / N. Ogata, J. Tombran-Tink -- The renin-angiotensin system in the eye / K. Strøder, T. Unger, U.M. Steckelings -- Interactions of leukocytes with the endothelium / T. Chavakis -- Stem and progenitor cells in the retina / N. Sengupta ... [et al.] -- Current approaches to retinopathy as a predictor of cardiovascular risk / N. Cheung, G. Liew, T.Y. Wong.
  • 2008 Springer
    N. Taniguchi ... [et al.], (eds.).
  • 2013 Springer
    Anastasia Malek, editor.
    Metastatic dissemination of cancer is a main cause of cancer related deaths, therefore biological mechanisms implicated in metastatic process presents an essential object of cancer research. This research requires creation and utilization of adequate laboratory models. The book describes main approaches to model processes of metastatic cancer dissemination and metastases development. The book is structured in according with various metastatic pathways reflecting molecular specificity of metastatic process as well as anatomical specificity of aria of dissemination.
  • 2011 Karger
    volume editor, Guillermo A. Herrera.
    Our understanding of the pathogenesis of renal diseases and the ability to accurately classify and diagnose them has improved considerably over the last two decades. Until now, however, this information has not been available in a single, up-to-date and succinct yet comprehensive source. The publication at hand aims at filling this gap, condensing a vast amount of information into easily accessible chapters. After a discussion of basic concepts and principles of renal tissue reactions to injurious agents using a specific cell/compartment approach, a multitude of disorders are looked at, including renal interstitial fibrosis, glomerulosclerosis, various forms of glomerulonephritis and nephropathy, amyloidosis and renal Fanconi syndrome. Some of the chapters address controversial subjects, reporting the current situation and showing areas of future potential research interest. At the end of many of the contributions, a summary is provided, often in the form of a chart to facilitate the understanding of the information and to make it most useful for didactic purposes. This book is intended for students of various disciplines, as well as clinicians and investigators and all those trying to correlate basic research information with clinical issues.
  • 2005 Springer
    edited by Ehud Lavi, Cris S. Constantinescu.
    Section D2. The pathogenesis of canine distemper virus induced demyelination: a biphasic process.
  • 2014 Thieme-Connect
    Hamish Simpson, Peter Augat.
  • v. 1, 1965.
    Jiménez Brundelet, Pablo.
    1. Histological study in rats of the intra-pulmonary bronchial route of elimination.
  • 2009 CRCnetBASE
    edited by Alfredo Rigalli, Verónica Elina Di Loreto.
    Bioethics and animal care -- Control of stress and distress -- Management of pain in laboratory animals -- Anesthesia and analgesia -- Euthanasia -- Antibiotics -- Operating theatre -- Rat identification -- Antisepsis, sterilization, and asepsis -- Suture -- Substances administration -- Samples -- Catheterization of the femoral artery and vein -- Cardiac catheterization -- Cannulation of the thoracic duct -- Tracheostomy -- In situ isolation of the stomach -- In situ isolation of the intestinal loop -- Intestinal everted sacs -- In situ perfusion of the small intestine -- Experimental models for the study of diabetes -- Islets of langerhans isolation -- Incubation of pancreatic tissue slices -- In situ perfusion of the pancreas -- Experimental pancreatitis -- Hepatic circulation impairment -- Extrahepatic cholestasis model -- Adrenalectomy -- Ovariectomy -- Thyroparathyroidectomy -- Parathyroid glands -- Measurement techniques of renal parameters -- Kidney isolation and perfusion -- Acute renal failure models -- Renal blood flow measurement -- Transport studies in plasma membrane vesicles isolated from renal cortex -- Remnant kidney model -- Experimental myocardial infarction -- Experimental arteriosclerosis -- Isolated heart: langendorff technique -- Polyclonal antibodies preparation -- Histological procedures -- Bones and bone tissue -- Equipment -- Solution preparation -- Normal values in IIm/Fm rat subline "M".
  • v. 1-2, 1911. Google Books
    Fulltext (v. 2) Google Books
    von Dr. W. Kolle ... und Dr. H. Hetsch ...
    Also available: Print – v. 1-2, 1911.
  • 2014 Wiley
    Michael D. Coleman.
    A brief history of occupational toxicology -- The expert report process in legal context -- Acute toxicity : case histories of solvent exposure -- Chronic and permanent injury : bladder cancer and occupation -- Chronic and acute toxicity of herbicides and pesticides -- Toxicity of imported goods.
  • 2008 CRCnetBASE
    Kenneth S. Cohen.
    Involvement in a legal action -- Negligence -- Rules of evidence and codes of civil procedure -- The body of scientific literature -- Foundation equals persuasion -- The expert witness -- Speaking the language of lawyers -- To do the courtroom dance, first learn the steps -- Skeletons in your closet -- Impeachment is not just for presidents! -- Criminal, civil, and workers' compensation cases -- Toxic torts in retrospect -- One case is tragic; two or more cases are an epidemic -- Professional liability -- Out of the ordinary : investigations, cases, and trials -- Do you charge for your testimony? No, I charge for my time! -- Expert witnesses : the good, the bad, and the ugly -- Closing arguments.
  • 2013
    Marcin Milkowski.
    Computation in cognitive science : four case studies and a funeral -- Computational processes -- Computational explanation -- Computation and representation -- Limits of computational explanation.
  • 2010
    Fraser Cameron.
    Type 1 Diabetes Mellitus or Juvenile Onset Diabetes is currently a permanent, incurable disease that removes the ability of the patient's body to control blood glucose levels. This loss of automatic control greatly increases the patient's exposure to clinical risks of high and low blood glucose levels. These risks can be mitigated through tight, regulation of blood glucose levels using insulin injections, but only at the price of paying frequent attention to the blood glucose levels and manually providing accurate dosing decisions. This can be very trying for all patients, especially teenagers and children. Recent technological advances enable automatic external regulation of patient's blood glucose levels. Pumps can infuse insulin into the subcutaneous tissue to lower blood glucose levels. Continuous glucose monitors can sense subcutaneous glucose levels, specifically the rises caused by meals and the drops caused by insulin. This has caused a flurry of control and modeling research, in the hopes of mitigating the clinical risk without the price of constant human attention. The most common approach, and the one taken here, is to use model predictive control, where the predictions from a model of glucose dynamics are optimized against a cost function using the future insulin injections. We directly minimize the asymmetric clinical risk instead, and recognize that our control authority (the potential effects of injecting insulin) is largely limited to reducing the blood glucose level. We further consider likely future blood glucose measurements, since we both respond better to positive disturbances than negative ones, and because negative disturbances are more risky. Also, we explicitly estimate the uncertainty of predictions, since glucose dynamics incorporate uncertainty from the complex biology, stochastic patient behaviour, and extrapolation. More uncertainty should mean more cautious insulin injection. Lastly, since meals occur faster than insulin acts and can raise the blood glucose by 2 to 4 times the width of the acceptable range, this work develops a novel Bayesian framework for detecting meals and estimating their effects. This work improves prediction root mean squared error by 20% relative to predictions excluding meals for prediction horizons from 1 to 4 hours and improves robustness to meals. These prediction improvements alone reduce the avoidable clinical risk by 38% relative to predictions excluding meals. When the improvements to the predictions are combined with minimizing clinical risk under uncertainty and measurement anticipation the avoidable clinical risk is reduced by 30% relative to a published MPC controller that has privileged information and tunes independently for each patient.
  • Click LINK above for Print location/circulation status.
    2005 CRCnetBASE
    Wendy L. Martinez, Angel R. Martinez.
  • 2011 CRCnetBASE
    François Husson, Sébastien Lê, Jérôme Pagès.
    "An introduction to exploratory techniques for multivariate data analysis, this book covers the key methodology, including principal components analysis, correspondence analysis, mixed models and multiple factor analysis. The authors take a practical approach, with examples leading the discussion of the methods and lots of graphics to emphasize visualization. They present the concepts in the most intuitive way possible, keeping mathematical content to a minimum or relegating it to the appendices. The book includes examples that use real data from a range of scientific disciplines and implemented using an R package developed by the authors"-- Provided by publisher.
  • 2005 MyiLibrary
    SU Catalog (SearchWorks) Click LINK above for Print location/circulation status.
    Wouter de Nooy, Andrej Mrvar, Vladimir Batagelj.
  • 2010
    Keyan Salari.
    Advances in genomic technologies have allowed investigators to survey diverse molecular properties of cancer cells including DNA copy number alterations, RNA transcript abundance, and protein-DNA binding events. While each data type offers a unique snapshot of the tumor cell, an integrated analysis of two or more complementary data types can reveal much more than the sum of its parts. In this dissertation, I describe new integrative genomic methodologies and novel biologic insights gleaned from their application. In one such analysis of 52 breast cancer cell lines, we identify genomic alterations and gene-expression profiles that largely resemble those identified in primary breast tumors, therefore defining relevant tumor models of breast cancer subtypes. Additionally, we identify 80 high-level DNA amplifications and 13 multi-copy deletions, harboring known and novel cancer genes, thereby providing a rich resource for new breast cancer gene discovery and characterization. In an integrative analysis of colorectal cancers, we unveil a region of amplification highly specific to colorectal-derived tumors. We identify and characterize caudal type homeobox transcription factor 2 (CDX2), a master regulator of intestinal cell survival and differentiation, as the target gene of this amplification, and show a CDX2 amplification-specific dependency for tumor cell survival, proliferation, and anchorage-independent growth. Moreover, by integrating protein-DNA binding and gene expression data, we uncover a novel relationship between CDX2 and Wnt/[beta]-catenin signaling. Taken together, these data show that for a subset of colorectal-derived tumors, cell survival and proliferation are dependent on the abnormal amplification and overexpression of CDX2, thereby characterizing CDX2 as a novel lineage-survival oncogene in colorectal cancer. In the last portion of the dissertation, I reflect on how the rapidly growing knowledgebase of genetic associations with disease and drug response will help usher in a new era of personalized medicine. To help prepare for a future that includes an array of available genomic laboratory tests, I discuss the necessity to reform medical school curricula to educate students about the interpretation, limitations, and impact of genomic testing in clinical medicine. I describe the challenges and considerations relevant to the development of a novel educational curriculum that includes personal genomic testing.
  • 2011 Springer
    Peter T. Robbins, Farah Huzair, editors.
  • 2012 Springer
    Alexander Moreira-Almeida, Franklin Santana Santos, editors.
    Part I. Philosophy and History -- 1. Materialism's Eternal Return: Recurrent Patterns of Materialistic Explanations of Mental Phenomena / Saulo de Freitas Araujo -- 2. The Major Objections from Reductive Materialism Against Belief in the Existence of Cartesian Mind-Body Dualism / Robert Almeder -- 3. Psychic Phenomena and the Mind-Body Problem: Historical Notes on a Neglected Conceptual Tradition / Carlos S. Alvarado -- Part II. Physics -- 4. No-Collapse Physics and Consciousness / Chris Clarke -- 5. The "Quantum Soul": A Scientific Hypothesis / Stuart Hameroff and Deepak Chopra -- Part III. Functional Neuroimaging -- 6. The Neurobiological Correlates of Meditationand Mindfulness / Jesse Edwards, Julio Peres, Daniel A. Monti, and Andrew B. Newberg -- 7. Functional Neuroimaging Studies of Emotional -- Self-Regulation and Spiritual Experiences / Mario Beauregard -- Part IV. Human Experiences as Promising lines of Investigation of Mind-Brain Relationship -- 8. Can Near Death Experiences Contribute to the Debate on Consciousness? / Peter Fenwick -- 9. Death, End of Life Experiences, and Their Theoretical and Clinical Implications for the Mind-Brain Relationship / Franklin Santana Santos and Peter Fenwick -- 10. Research on Mediumship and the Mind-Brain Relationship / Alexander Moreira-Almeida -- 11. Cases of the Reincarnation Type and the Mind-Brain Relationship / Erlendur Haraldsson -- 12. Conclusion / Alexander Moreira-Almeida and Franklin Santana Santos.
  • 2007 Springer
    Alexander G. Karczmar ; with contributions by Neelima Chauhan ... [et al.] ; with a foreword by Victor P. Whittaker.
  • 2013
    Sara Shostak.
    Status: Not Checked OutLane Catalog Record
  • 2014 ScienceDirect
    Gary W. Miller.
  • 2007 CRCnetBASE
    edited by Wayne R. Ott, Anne C. Steinemann, Lance A. Wallace.
  • WHO
    World Health Organization, Food and Agriculture Organization of the United Nations.
    Exposure assessment is one of the four steps of microbiological risk assessment. This volume provides guidelines for the exposure assessment of microbiological hazards in food. It outlines the principles of exposure assessment as well as the data needed and approaches available for carrying out exposure assessment.--Publisher's description.
    Also available: Print – 2008
  • 2009 Springer Protocols
    edited by John Parkinson.
    Expressed sequence tags : an overview / John Parkinson and Mark Blaxter --Strategies for undertaking expressed sequence tag (EST) projects / Sandra W. Clifton and Makedonka Mitreva -- Construction of cDNA libraries : focus on protists and fungi / Naiara Rodríguez-Ezpeleta ... [et al.] -- Generation of full-length cDNA libraries : focus on plants / Motoaki Seki ... [et al.] -- Preparation of full-length cDNA libraries : focus on metazoans / Masako Harada and Yoshihide Hayashizaki -- Expressed sequence tags : normalization and subtraction of cDNA libraries / Marcelo Bento Soares ... [et al.] -- Generating EST libraries : trans-spliced cDNAs / Cecilia Fernández and Rick M. Maizels -- Large-scale sequencing and analytical processing of ESTs / Makedonka Mitreva and Elaine R. Mardis -- EST processing : from trace to sequence / Ralf Schmid and Mark Blaxter -- Obtaining accurate translations from expressed sequence tags / James Wasmuth and Mark Blaxter -- EST databases and web tools for EST projects /Yao-Qing Shen ... [et al.] -- Phylogenomic analysis of EST datasets / José M. Peregrín-Alvarez and John Parkinson -- Statistical analysis of expressed sequence tags / Edward Susko and Andrew J. Roger -- Application of ESTs in microarray analysis / Weizhong Li ... [et al.] -- Exploiting ESTs in human health / Sandro José de Souza.
  • 2012 Springer Protocols
    edited by Yannis Karamanos.
    1. DNA microarrays for gene expression analysis in brain tissue and cell lines / Gustavo A. Barisone and Elva Diaz -- 2. Gene expression profiling using the terminal continuation RNA amplification method for small input samples in neuroscience / Stephen D. Ginsberg, Melissa J. Alldred, and Shaoli Che -- 3. Expression profiling in brain disorders / Peter J. Gebicke-Haerter -- 4. Endothelial cell heterogeneity of blood-brain barrier gene expression: analysis by LCM/qRT-PCR / Tyler Demarest, Nivetha Murugesan, Jennifer A. Macdonald, and Joel S. Pachter -- 5. Gene expression profiling using 3' tag digital approach / Yan W. Asmann, E. Aubrey Thompson, and Jean-Pierre A. Kocher -- 6. Sharing expression profiling data with gemma / Anton Zoubarev and Paul Pavlidis -- 7. Two-dimensional protein analysis of neural stem cells / Martin H. Maurer -- 8. iTRAQ proteomics profiling of regulartory proteins during oligodendrocyte differentiation / Mohit Raja Jain, Tong Liu, Teresa L. Wood, and Hong Li -- 9. Protein profiling of the brain: proteomics of isolated tissues and cells / Nicole Haverland and Pawel Ciborowski -- 10. The proteome of brain capillary endothelial cells: toward a molecular characterization of an in vitro blood-brain barrier model / Sophie Duban-Deweer, Christophe Flahaut, and Yannis Karamanos -- 11. MALDI imaging technology applications in neurosciences: from history to perspectives / Michael Salzet, Céline Mériaux, Julien Franck, Maxence Wistorsi, and Isabelle Fournier -- 12. Profiling of HIV proteins in cerebrospinal fluid / Melinda Wojtkiewicz and Pawel Ciborowski -- 13. Proteomic profiling of cerebrospinal fluid / Gwenael Pottiez and Pawel Ciboroski -- 14. New nanotechnology applications in single cell analysis: why and how? / Gradimir N. Misevic, Gerard BenAssaya, Bernard Rasser, Philippe Sales, Jovana Simic-Krstic, Nikola Misevic, and Octavian Popescu.
  • 2013
    Ronald Chen.
    Lung cancer is the deadliest cancer worldwide. Survival rates for the most common histological subtype, non-small cell lung cancer (NSCLC), have remained 15% over the past several decades. New molecular understandings and treatments are required to advance NSCLC patient care. Here we use several gene expression-based methods to uncover novel dependencies within NSCLC. First, we use cross-species functional genomics to identify TCEB1 (Elongin C) as a novel synthetic lethal partner with mutant KRAS. Secondly, we use gene expression meta-analysis to identify PTK7 as a survival gene in a subset of lung adenocarcinoma, the major type of NSCLC. Our work demonstrates the utility of analyzing gene expression data sets to expose functionally relevant genes within NSCLC, which may lead to effective therapies.
  • 2007
    Jessica Dale Tenenbaum.
    Status: Not Checked OutLane Catalog Record
  • 2012 Springer
    David Seligson, Cyril Mauffrey, Craig Roberts, editors.
    1. Damage Control Orthopedics in the Polytrauma Patient / Hans-Christoph Pape, Thomas Dienstknecht, and Peter V. Giannoudis -- 2. Limb Damage Control Orthopedics / Madhusudhan Yakkanti, Cyril Mauffrey, and Craig S. Roberts -- 3. Practical Biomechanical Considerations about External Fixators / Cyril Mauffrey, Dennis Beck, and Laura Ruhala -- 4. External Fixation in Economically Disadvantaged Areas / David Seligson, N.S. Laud, and Alfredo Aybar Montoya -- 5. External Fixation in the War Zone / Paul J. Dougherty and Kimberly M. Kesling -- 6. External Fixation of the Pelvis in Damage Control Orthopedics / Madhusudhan Yakkanti and Craig S. Roberts -- 7. External Fixation About the Wrist and the Forearm / Cyril Mauffrey, David Seligson, and Jonathan Yerasimide / 8. External Fixators in the Treatment of Tibial Plateau Fractures / V. Manakavala Perumal, Cyril Mauffrey, and Craig S. Roberts -- 9. The Use of External Fixators in the Acute Management of Tibial Pilon Fractures / Cyril Mauffrey, David Seligson, and Jessica Heinsen -- 10. External Fixation of Long Bones / Dennis Beck and Charles Daniel Benson -- 11. The Care and Management of Patients with External Fixators / David Seligson and Janet Macphaden -- 12. Complications of External Fixation / G. Zych -- 13. Timing and Strategies for Definitive Fixation After a Damage Control Frame / Thomas De Coster -- 14. Medico Legal Considerations Surrounding the Injured Patient / David Seligson and Charles Daniel Benson.
  • 2010 Springer
    Evgenia Gerasimovskaya, Elzbieta Kaczmarek, editors.
  • 2014 Springer Protocols
    edited by Jennie B. Leach, Elizabeth M. Powell.
    This volume provides comprehensive procedures for analyzing the extracellular matrix in native, injured, and engineered neural tissues. Divided into four parts, each focusing on different aspects of the extracellular matrix and the nervous system, Extracellular Matrix covers methods to analyze native tissue, in vitro models for investigating cell-extracellular matrix interactions in a variety of contexts, protocols to investigate the role of the extracellular matrix in nervous system injury, degeneration, and regeneration, as well as therapeutics and engineered systems. Each chapter is written by leading experts and presents established protocols in a concise format, encompassing current technologies as well as methods developed over years of research. Beginning with an introduction to the method, chapters continue with a listing of the materials and equipment, step-by-step protocols, and a Notes section with troubleshooting tips, supplemental details and alternative approaches, as well as a list of references for further information.
  • 2011 Springer
    Robert P. Mecham, editor.
    An overview of extracellular matrix structure and function / Jürgen Engel and Matthias Chiquet -- Fibronectin and other adhesive glycoproteins / Jielin Xu and Deane Mosher -- Collagens, suprastructures, and collagen fibril assembly / David E. Birk and Peter Brückner -- Basement membranes / Jeffrey H. Miner -- Hyaluronan and the aggregating proteoglycans / Thomas N. Wight, Bryan P. Toole, and Vincent C. Hascall -- Small leucine-rich proteoglycans / Renato V. Iozzo ... [et al.] -- Microfibrils and fibrillin / Dirk Hubmacher and Dieter P. Reinhardt -- Elastin / Beth A. Kozel, Robert P. Mecham, and Joel Rosenbloom -- Lysyl oxidase and lysyl oxidase-like enzymes / Herbert M. Kagan and Faina Ryvkin -- The fibulins / Marion A. Cooley and W. Scott Argraves -- Matricellular proteins / David D. Roberts and Lester F. Lau.
    Also available: Print – 2011
  • 2006
    Walter Patrick Devine.
    Status: Not Checked OutLane Catalog Record
  • ScienceDirect
    edited by Erkki Ruoslahti, Eva Engvall.
    Also available: Print – 1994
  • 2011 Springer
    William C. Parks, Robert P. Mecham, editors.
    Matrix metalloproteinases and their inhibitors in turnover and degradation of extracellular matrix / Sean E. Gill and William C. Parks -- Role of cysteine cathepsins in extracellular proteolysis / Dieter Brömme and Susan Wilson -- Cooperation between proteolysis and endocytosis in collagen turnover / Thomas H. Bugge and Niels Behrendt -- Pericellular proteolysis / Judith S. Bond, Timothy R. Keiffer, and Qi Sun -- Triple helicase activity and the structural basis of collagenolysis / Hideaki Nagase and Robert Visse -- Structural basis of extracellular matrix interactions with matrix metalloproteinases / Steven R. Van Doren -- The role of matrix metalloproteinases in cellular invasion and metastasis / Elena I. Deryugina and James P. Quigley -- Degradation of bone and the role of osteoclasts, bone lining cells and osteocytes / Vincent Everts and Paul Saftig -- Consequences of elastolysis / A. McGarry Houghton, Majd Mouded, and Steven D. Shapiro.
    Also available: Print – 2011
  • 2013 Springer
    Douglas W. DeSimone, Robert P. Mecham, editors.
    Cells in the developing embryo depend on signals from the extracellular environment to help guide their differentiation. An important mediator in this process is the extracellular matrix - secreted macromolecules that interact to form large protein networks outside the cell. During development, the extracellular matrix serves to separate adjacent cell groups, participates in establishing morphogenic gradients, and, through its ability to interact directly will cell-surface receptors, provides developmental clocks and positional information. This volume discusses how the extracellular matrix influences fundamental developmental processes and how model systems can be used to elucidate ECM function. The topics addressed range from how ECM influences early development as well as repair processes in the adult that recapitulate developmental pathways.The series Biology of Extracellular Matrix is published in collaboration with the American Society for Matrix Biology.
    Also available: Print – 2013
  • 2009 Springer Protocols
    edited by Sharona Even-Ram and Vira V. Artym.
    Retroviral delivery of ECM genes / Vitali alexeev and Olga Igoucheva -- Tissue-specific KO of ECM proteins / Mara Brancaccio, Emila Turco, and Emilio Hirsch -- Recombinant collagen trimers from insect cells and yeast / Johanna Myllyharju -- Eukaryotic expression and purification of recombinant extracellular matrix proteins carrying the Strep II tag / Neil Smyth ... [et al.] -- Preparation of recombinant fibronectin fragments for functional and structural studies / David Staunton ... [et al.] -- Quantitative determination of collagen cross-links / Nicholas C. Avery, Trevor J. Sims, and Allen J. Bailey -- ECM macromolecules : height-mapping and nano-mechanics using atomic force microscopy / Nigel W. Hodson, Cay M. Kielty, and Michael J. Sherratt -- Atomic force microscopy measurements of intermolecular binding forces / Gradimir N. Misevic, Yannis Karamanos, and Nikola J. Misevic -- Mass-mapping of ECM macromolecules by scanning transmission electron microscopy / Michael J. Sherratt ... [et al.] -- Chemical microscopy of biological samples by dynamic mode secondary ion mass spectrometry / Gradimir N. Misevic ... [et al.] -- ECM macromolecules : rotary shadowing and transmission electron microscopy / Michael J. Sherratt ... [et al.] -- Using self-assembled monolayers to pattern ECM proteins and cells on substrates / Emanuele Ostuni ... [et al.] -- Solid phase assays for studying ECM protein-protein interactions / A. Paul Mould -- Cell adhesion assays / Martin J. Humphries -- ECM degradation assays for analyzing local cell invasion / Vira V. Artym, Kenneth M. Yamada, and Susette C. Mueller -- Fluorescence-based assays for in vitro analysis of cell adhesion and migration / Paola Spessotto ... [et al.] -- Fibrin gel model for assessment of cellular contractility / Sharona Even-Ram -- Fluorescent labeling techniques for investigation of fibronectin fibrillogenesis (labeling fibronectin fibrillogenesis) / Roumen Pankov and Albena Momchilova -- Stromagenesis during tumorigenesis : characterization of tumor-associated fibroblasts and stroma-derived 3D matrices / Remedios Castelló-Cros and Edna Cukierman -- Tissue recombinants to study extracellular matrix targeting to basement membranes / Patricia Simon-Assmann ... [et al.] -- ECM and FGF-dependent assay of embryonic SMG epithelial morphogenesis : investigating growth factor/matrix regulation of gene expression during submandibular gland development / Ivan T. Rebustini and Matthew P. Hoffman -- Analyzing how cell adhesion controls mammary gland function by transplantation of embryonic mammary tissue from knockout mice / Teresa C.M. Klinowska and Charles H. Streuli -- Characterizing ECM production by cells encapsulated in hydrogels / Iossif A. Strehin and Jennifer H. Elisseeff -- Tissue engineering and cell-populated collagen matrices / Paul D. Kemp.
  • 2010 Springer
    Yo Kikuchi, Elena Y. Rykova (eds.).
    Extracellular DNA as Matrix Component in Microbial Biofilms / Wen-Chi Chiang and Tim Tolker-Nielsen -- Gene Transfer Agents and Defective Bacteriophages as Sources of Extracellular Prokaryotic DNA / Andrew S. Lang and J. Thomas Beatty -- Roles of Extracellular DNA in Bacterial Ecosystem / Katsuji Tani and Masao Nasu -- Stable Extracellular DNA: A Novel Substrate for Genetic Engineering that Mimics Horizontal Gene Transfer in Nature / Shinya Kaneko and Mitsuhiro Itaya -- Extracellular Nucleic Acids of the Marine Phototrophic Bacterium Rhodovulum sulfidophilum and Related Bacteria: Physiology and Biotechnology / Yo Kikuchi -- Systemic RNAi in C. elegans from the Viewpoint of RNA as Extracellular Signals / Lisa Timmons -- Circulating Nucleic Acids in Health and Disease / E. Y. Rykova, P. P. Laktionov and V. V. Vlassov -- Circulating MicroRNAs in Cancer / Patrick S. Mitchell and Muneesh Tewari -- Biology and Diagnostic Applications of Cell-Free Fetal Nucleic Acids in Maternal Plasma / Jason C. H. Tsang and Y. M. Dennis Lo -- The Biology of Circulating Nucleic Acids in Plasma and Serum (CNAPS) / P. B. Gahan and M. Stroun -- Modulation and Regulation of Gene Expression by CpG Oligonucleotides / Dennis Klinman and Sven Klaschik -- Immune Recognition of Nucleic Acids and Their Metabolites / Shohei Koyama, Shizuo Akira and Ken J. Ishii.
  • 2014 CRCnetBASE
    edited by Paul Harrison, Chris Gardiner, Ian L. Sargent.
    1. Overview of extracellular vesicles in health and disease / Rienk Nieuwland, Edwin van der Pol, and Augueste Sturk -- 2. The biogenesis of exosomes / D. Michiel Pegtel -- 3. Extracellular vesicle-mediated epigenetic reprogramming of cells / Giovanni Camussi, Federica Collino, and Maria C. Deregibus -- 4. An overview of novel and conventional methods to detect extracellular vesicles / Edwin van der Pol, Ton G. van Leeuwen, and Rienk Nieuwland -- 5. Preanalytical variables / Romaric Lacroix, Coralie Judicone, Stéphane Robert, Laurent Arnaud, Florence Sabatier, and Françoise Dignat-George -- 6. Procoagulant assays / Barry J. Woodhams -- 7. Capture-based assays for extracellular vesicles within the blood / Jean Amiral -- 8. Flow cytometry / Romaric Lacroix, Stephane Robert, Florence Sabatier, and Francoise Dignat-George -- 9. Atomic force microscopy measurement of extracellular vesicles derived from plasma / Yuana Yuana and Susanne Osanto -- 10. Light-scattering methods to characterize extracellular vesicles / Don A. Gabriel, Sam Glover, Regina Bowling, and Nigel Key -- 11. Nanoparticle tracking analysis / Chris Gardiner and Rebecca Dragovic -- 12. Extracellular vesicle proteomic analysis / Andrés F. Parguiña and Ángel García -- 13. Microvesicles and exosomes in cancer / Rebecca Karp and Jeffrey Zwicker -- 14. Extracellular vesicles and tissue factor / Pierre-Emmanuel Rautou and Nigel Mackman -- 15. Extracellular vesicles in normal pregnancy and pre-eclampsia / Ian L. Sargent, Rebecca A. Dragovic, Dionne S. Tannetta, and Christopher W. Redman -- 16. Extracellular vesicles in cardiovascular disease / Anne-Clémence Vion and Chantal M. Boulanger -- 17. Extracellular vesicles in immunology / Els J. van der Vlist, Esther N.M. Nolte-'t Hoen, and Marca H.M. Wauben.
  • 2016 Springer
    Gregory A. Schmidt, editor.
    Physiology of Extracorporeal Life Support (ECLS), Matthew J. Brain, Warwick W. Butt, Graeme MacLaren -- Hypoxemic Respiratory Failure: Evidence, Indications, Exclusions, Darryl Abrams, Matthew Bacchetta, Daniel Brodie -- Cardiogenic Shock: Evidence, Indications, Exclusions, Nicolas Bréchot, Alain Combes -- ECCO2R in Obstructive Diseases: Evidence, Indications, Exclusions, Lorenzo Del Sorbo, V. Marco Ranieri -- ECLS as a Bridge to Lung Transplantation, Christian Kuehn.- Modes of ECLS, L. Keith Scott, Benjamin Schmidt -- Vascular Access for ECLS, Steven A. Conrad -- Circuits, Membranes, and Pumps, Bradley H. Rosen -- Ventilator Management during ECLS, Antonio Pesenti, Giacomo Bellani, Giacomo Grasselli, Tommaso Mauri -- Daily Care on ECLS, Giles J. Peek -- Crises during ECLS, Cara L. Agerstrand, Linda B. Mongero, Darryl Abrams, Matthew Bacchetta, Daniel Brodie -- Mobilization during ECLS, Gregory A. Schmidt -- ECMO Weaning and Decannulation, Sundar Krishnan and Gregory A. Schmidt -- The Story of ECLS: History and Future, J. Ann Morris, Robert Pollock, Brittany A. Zwischenberger, Cherry Ballard-Croft, Joseph B. Zwischenberger.
  • 2011 Cambridge
    edited by Bachir Taouli.
    Basic physical principles of body diffusion-weighted imaging / Eric E. Sigmund and Jens Jensen -- Diffusion-weighted MRI of the liver / Bachir Taouli and Dow-Mu Koh -- Diffusion-weighted MRI of diffuse renal disease and kidney transplant / Frederik De Keyzer and Harriet C. Thoeny -- Diffusion-weighted MRI of focal renal masses / Sooah Kim and Bachir Taouli -- Diffusion-weighted MRI of the pancreas / Tomoaki Ichikawa ... [et al.] -- Diffusion-weighted MRI of the prostate / Sophie F. Riches and Nandita DeSouza -- Breast applications of diffusion-weighted MRI / Yong Guo -- Diffusion-weighted MRI of lymph nodes / Thomas C. Kwee and Taro Takahara -- Diffusion-weighted MRI of female pelvic tumors / Hela Sbano and Anwar R. Padhani -- Diffusion-weighted MRI of the bone marrow and the spine / Olaf Dietrich and Andrea Baur-Melnyk -- Diffusion-weighted MRI of soft tissue tumors / Masayuki Maeda -- Evaluation of tumor treatment response with diffusion-weighted MRI / Andriy M. Babsky, Shenghong Ju and Navin Bansal -- Diffusion-weighted MRI: future directions / Dow-Mu Koh and David J. Collins.
  • 2011 ScienceDirect
    2011 ClinicalKey
    Judith A. Ferry.
    Introduction to extranodal lymphomas / Judith A. Ferry -- Lymphomas of the nervous system and the meninges / Judith A. Ferry -- Lymphomas of the head and neck / Judith A. Ferry -- Lymphomas of the thorax / Judith A. Ferry -- Lymphomas of the esophagus, gastrointestinal tract, hepatobiliary tract, and pancreas / Judith A. Ferry -- Lymphomas of the spleen / Aliyah R. Sohani and Lawrence R. Zukerberg -- Adrenal lymphomas / Judith A. Ferry -- Lymphomas of the urinary tract / Judith A. Ferry -- Lymphomas of the male genital tract / Judith A. Ferry -- Lymphomas of the female genital tract / Judith A. Ferry -- Cutaneous lymphomas / Lyn M. Duncan, Johanna l. Baran, and Judith A. Ferry -- Lymphomas of bone / Judith A. Ferry -- Lymphomas of the bone marrow / Robert P. Hasserjian -- Intravascular lymphomas / Judith A. Ferry.
  • 2006 CRCnetBASE
    Karl H.E. Kroemer.
  • 2010 Springer
    I. Mader, P.R. Fürst-Weger, R.M. Mader, E. Nogler-Semenitz, S. Wassertheurer.
  • 2006/2007
    Kerrin Shannon Small.
    Status: Not Checked OutLane Catalog Record
  • 2014
    Kevin Fong, M.D.
    An anesthesiologist and NASA adviser explores how pioneering doctors and scientists have built on findings about the body's response to extreme environments and physical challenges to develop such medical innovations as open-heart surgery, skin grafts, and trauma care.
  • 2012 Wiley
    Robert Brown.
  • 2005 Springer
    W. Kirch, B. Menne, and R. Bertollini (editors).
  • 2007
    Status: Not Checked OutLane Catalog Record
  • 2015 Springer
    A. Neil Salyapongse, Samuel O. Poore, Ahmed M. Afifi, Michael L. Bentz, editors.
    Extremity Replantation is a comprehensive text covering all aspects of the upper and lower limb, with an emphasis on state-of-the-art techniques in the surgical and medical management of amputation and avulsion injuries as well as the current understanding of the recovery of function following replantation. It is organized following anatomical zones ? thumb, digits, wrist, forearm and elbow; foot, ankle and lower leg ? with special chapters dedicated to issues common to all replants, such as complications, medical management, nerve recovery and rehabilitation. Furthermore, the international team of authors demonstrates approaches from the entire spectrum of replantation care specialists, including plastic and reconstructive surgeons, orthopedists, and hand therapists. Generously illustrated with intra-operative photos, this book will serve as a standard reference for orthopedic, reconstructive, plastic, and hand surgeons as well as physicians or ancillary medical staff caring for the replant patient.
  • 2007 ScienceDirect
    edited by Fred A. Rainey and Aharon Oren.
    Also available: Print – 2006
  • 2015 Springer
    Sikha Mandal, Jnanendra Rath.
    This volume presents recent developments in the novel drug development and potential of extremophilic cyanobacteria. It discusses how these tiny organism originated, produce oxygen that leads to evolution of life on the earth, how their survival strategies in extreme climatic conditions lead to diverse metabolic pathways, and the opportunity to use them to develop novel drugs. The book is comprised of five chapters, starting with the origin of cyanobacteria, their survival strategies under extreme conditions, and their capabilities to change metabolic activities.The second chapter explores the different metabolic pathways found in cyanobacteria and examines advances in this field and recent techniques like MALDI-TOF imaging and metagenomics tools as well as in silico techniques for rapid screening of secondary metabolites. Further chapters cover the glycomics of cyanobacteria, anticancer drug development, and some issues and challenges of using cyanobacteria to develop drugs. Extremophilic Cyanobacteria For Novel Drug Development provides insight into future perspectives in drug development and is a key resource for students, researchers and professionals in pharmacy, medicinal chemistry, pharmacognosy biotechnology, biology, and academics.
  • 2009
    Vivian Yi Nuo Poon.
    Status: Not Checked OutLane Catalog Record
  • 2016 ClinicalKey
    John V. Forrester, Andrew D. Dick, Paul G. McMenamin, Fiona Roberts, Eric Pearlman.
    1. Anatomy of the eye and orbit -- 2. Embryology and early development of the eye and adnexa -- 3. Genetics -- 4. Biochemistry and cell biology -- 5. Physiology of vision and the visual system -- 6. General and ocular pharmacology -- Immunology -- 7. Microbial infections of the eye -- 8. Pathology.
  • 2008
    John V. Forrester, Andrew D. Dick, Paul G. McMenamin, Fiona Roberts.
    Status: Not Checked OutLane Catalog Record
    Anatomy of the eye and orbit -- Embryology and early development of the eye and adnexa -- Genetics -- Biochemistry and cell biology -- Physiology of vision and the visual system -- General and ocular pharmacology -- Immunology -- Microbiology and infection -- Pathology.
  • 2009 Karger
    volume editors, Timm Bredehorn-Mayr, Gernot I.W. Duncker, W. John Armitage.
    Corneal grafting and banking / Ehlers, N., Hjortdal, J., Nielsen, K. -- European Eye Bank Association / Jones, G.L.A. ... [et al.] -- Donor selection, retrieval and preparation of donor tissue donor selection / Borderie, V.M. -- Organ culture preservation for corneal tissue technical and quality aspects / Pels, E., Rijneveld, W.J. -- Endothelial evaluation in the cornea bank / Schroeter, J., Rieck, P. -- Cryopreservation for corneal storage / Armitage, W.J. -- Quality management in European eye banks / Toniolo, M. ... [et al.] -- Allocation of corneas in Europe / Bokhorst, A.G., Dorrepaal, C.A. -- Preparation and preservation of amniotic membrane / Dekaris, I., Gabrić, N. -- Preparation and use of human sclera grafts in ophthalmic surgery / Töteberg-Harms, M., Bredehorn-Mayr, T. -- Culturing of retinal pigment epithelium cells / Valtink, M., Engelmann, K. -- Costs and financing : a cost calculation of an up-to-date eye bank in Germany / Böhringer, D. ... [et al.] -- Practical implications of the law on tissues for cornea banks in Germany / Hauswald, C., Bredehorn-Mayr, T. -- European Association of Tissue Banks / Cahane, M., Van Baare, J.
    Also available: Print – 2009
  • 2015 Springer
    Steffen Heegaard, Hans Grossniklaus, editors.
    This book is a comprehensive, in-depth, and up-to-date resource on eye pathology that will be of great practical value for ophthalmic and general pathologists and ophthalmologists. Congenital abnormalities, inflammatory conditions, infections, injuries, degenerative diseases, and tumors are all covered with the aid of more than 700 images. In the case of tumors, the wide variety of neoplasms that occur in the eyelid, conjunctiva, retina, uveal tract, lacrimal gland and sac, orbit, and optic nerve are comprehensively reviewed, and the most recent knowledge on the relation between genetics and prognosis is presented. Entries on specific diseases are organized in a standard way, with information on etiology, epidemiology, clinical presentation, pathological characteristics, differential diagnosis, therapy, and prognosis. The authors are all recognized experts and members of the European and American ophthalmic pathology societies.
  • v. <1>y<1984>, 1984-
    edited by Hugh Davson.
    Status: Not Checked OutLane Catalog Record
    v. 1. Vegetative physiology and biochemistry.
  • 2008
    edited by Leo M. Chalupa and Robert W. Williams.
    Status: Not Checked OutLane Catalog Record
    Evolutionary history of the genus Mus / Priscilla K. Tucker -- Visual and other sensory abilities of mice and their influence on behavioral measures of cognitive function / Aimée A. Wong and Richard E. Brown -- Comparative survey of the mammalian visual system with reference to the mouse / Catherine A. Leamey, Dario A. Protti and Bogdan Dreher -- Survey of the research opportunities afforded by genetic variation in the mouse visual system / Lawrence H. Pinto and John B. Troy -- The mouse as a model for myopia, and optics of its eye / Frank Schaeffel -- Characteristics and applications of mouse eye movements / John S. Stahl -- Measuring vision in the awake behaving mouse / Glen T. Prusky and Robert M. Douglas -- Electroretinographic correlates of normal and abnormal retinal ganglion cell activity / Vittorio Porciatti -- Aqueous humor dynamics and trabecular meshwork / Ernst R. Tamm and Antonia Kellenberger -- Recent advances in the investigation of mouse cone photoreceptors / Arkady Lyubarsky ... [et al.] -- Mosaic architecture of the mouse retina / Benjamin E. Reese -- Synaptic organization of the mouse retina / Enrica Strettoi -- Distribution and functional roles of neuronal gap junctions in the mouse retina / Stewart A. Bloomfield and Béla Völgyi -- Neurotransmission in the mouse retina / Maureen A. McCall, Neal S. Peachey and Ronald G. Gregg -- Morphological, functional, and developmental properties of mouse retinal ganglion cells / Julie L. Coombs and Leo M. Chalupa -- The lamina cribrosa region and optic nerve of the mouse / Christian-Albrecht May -- Photoentrainment of the circadian oscillator / Satchidananda Panda -- Physiology of the mouse dorsal lateral geniculate nucleus / Matthew S. Grubb -- Superior colliculus and saccade generation in mice / Tomoya Sakatani and Tadashi Isa -- Interconnections of visual cortical areas in the mouse / Andreas Burkhalter and Quanxin Wang -- Chronology of development of the mouse visual system : comparisons with human development / Barbara L. Finlay and Barbara Clancy -- Developmental studies of the mouse lens : past, present, and future / Michael L. Robinson -- Development of the retinal vasculature and the effects of high oxygen (retinopathy of prematurity) / Michael R. Powers -- Specification, histogenesis, and photoreceptor development in the mouse retina / Deepak Lamba ... [et al.] -- Rb and the control of retinal development / Michael A. Dyer -- Gene regulatory networks and retinal ganglion cell development / Xiuqian Mu and William H. Klein -- Cell death in the mouse retina / Lucia Galli-Resta and Maria Cristina Cenni -- The function of the retina prior to vision : the phenomenon of retinal waves and retinotopic refinement / Marla B. Feller and Aaron G. Blankenship -- On and Off pathways in the mouse retina and the role of stimulation / Ning Tian -- Retinoic acid function in central visual pathways / Ursula C. Drager, Tuanlian Luo and Elisabeth Wagner -- Intraretinal axon guidance / Lynda Erskine and Hannah Thompson -- Early development of the optic stalk, chiasm, and astrocytes / Timothy J. Petros and Carol A. Mason -- Axon growth and regeneration of retinal ganglion cells / Jeffrey L. Goldberg -- Development of the retinogeniculate pathway / William Guido -- Developmental synaptic remodeling : insights from the mouse retinogeniculate synapse / Chinfei Chen -- Ocular dominance plasticity / Mark Hübener, Sonja B. Hofer and Thomas D. Mrsic-Flogel -- Environmental enrichment and visual system plasticity / Alessandro Sale, Nicoletta Berardi and Lamberto Maffei -- Bidirectional experience-dependent plasticity in primary visual cortex / Mikhail Y. Frenkel and Mark F. Bear -- Mouse models : a key system in revolutionizing the understanding of glaucoma / Gareth R. Howell, Jeffrey K. Marchant and Simon W.M. John -- Cataract genetics / Jochen Graw -- Mouse models of infectious eye diseases / Linda D. Hazlett -- Mouse models of autoimmune and immune-mediated uveitis / Rachel R. Caspi -- Mouse models of Norrie disease / Wolfgang Berger -- The lipofuscin of retinal pigment epithelial cells : learning from mouse models of retinal disease / Janet R. Sparrow ... [et al.] -- Studies of diabetic retinopathy using mice / Rose A. Gubitosi-Klug and Timothy S. Kern -- Roles of oxygen in the stability of photoreceptors : evidence from mouse and other models of human disease / Jonathan Stone and Krisztina Valter -- Complex genetics of photoreceptor light damage / Michael Danciger -- Age-related eye diseases / Bo Chang -- New genetic technologies for studying the morphology, physiology, and development of mouse retinal neurons / Tudor C. Badea and Jeremy Nathans -- Adenoassociated virus gene therapy in mouse models of retinal degeneration / Shannon E. Boye, Sanford L. Boye and William W. Hauswirth -- Delivery of plasmids into the visual system using electroporation / Takahiko Matsuda and Constance L. Cepko -- Genetic knockouts in ophthalmic research and drug discovery / Dennis S. Rice -- Beyond positional cloning of single gene mutations : use of mouse models to examine allelic variance and to identify genetic modifiers / Patsy M. Nishina and Juergen K. Naggert -- The mouse eye transcriptome : cellular signatures, molecular networks, and candidate genes for human disease / Eldon E. Geisert and Robert W. Williams -- Mouse models, microarrays, and genetic networks in retinal development and degenerative disease / Sunil K. Parapuram and Anand Swaroop -- Retinal vascular and retinal pigment epithelium gene expression / Michael I. Dorrell and Martin Friedlander -- Gene expression in cornea and lens / Shivalingappa K. Swamynathan and Joram Piatigorsky -- Proteomics of the mouse lens / Wolfgang Hoehenwarter and Peter R. Jungblut -- Genetic and proteomic analyses of the mouse visual cycle / John C. Saari and John W. Crabb.
  • 2014 Springer
    Arnab Biswas.
    Eyelid tumors are commonly encountered by oculoplastic as well as plastic surgeons. The challenge of managing these cases lies not only in performing the surgery in a precise manner in small area, but also in ensuring a visually-appealing cosmetic outcome. This is an innovative and concise portable handbook that guides the surgeons on how to approach and manage these cases in a step-by-step manner. Each chapter of this practical guidebook has outstanding illustrations drawn in full color clearly showing each incision line, flap management, suture placement and its technique, and the expected cosmetic outcome. When a lid tumor is excised, there is a tissue defect that needs to be corrected. Ophthalmologists and plastic surgeons will find this work an excellent reference material to solve the jigsaw puzzle of tissue defects in and around the periorbital region. Importantly, they can quickly refer to the images just before starting a procedure. The author has first explained the anatomical aspects and anesthetic techniques for eyelid surgery, followed by review of the benign and malignant tumors, finally describing the flap creation and reconstruction techniques that are currently used in various lid tumors in an organized fashion.

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