Lane Medical Library

1. Enzyme Activities and Microbiological and Biochemical Processes in Soil / Paolo Nannipieri, Ellen Kandeler, and Pacifico Ruggiero -- 2. Ecology of Microbial Enzymes in Lake Ecosystems / Ryszard Jan Chróst and Waldemar Siuda -- 3. Ecological Significance of Bacterial Enzymes in the Marine Environment / Hans-Georg Hoppe, Carol Arosti, and Gerhard F. Herndl -- 4. Enzymes and Microorganisms in the Rhizosphere / David C. Naseby and James M. Lynch -- 5. Enzymes in the Arbuscular Mycorrhizal Symbiosis / José Manuel García-Garrido, Juan Antonio Ocampo, and Inmaculada García-Romera -- 6. Microbes and Enzymes Associated with Plant Surfaces / Alan P. Thompson and Mark J. Bailey -- 7. Microbial Enzymes in the Biocontrol of Plant Pathogens and Pests / Leonid Cherin and Ilan Chet -- 8. Microbiology and Enzymology of Carbon and Nitrogen Cycling / Robert L. Tate III -- 9. Enzyme and Microbial Dynamics of Litter Decomposition / Robert L. Sinsabaugh, Margaret M. Carreiro, and Sergio Alvarez -- 10. Fungal Communities, Succession, Enzymes, and Decomposition / Annelise H. Kjøller and Sten Struwe -- 11. Enzyme Adsorption on Soil Mineral Surfaces and Consequences for the Catalytic Activity / Hervé Quiquampoix, Sylvie Servagent-Noinville, and Marie-Hélène Baron -- 12. Microbes and Enzymes in Biofilms / Jana Jass, Sara K. Roberts, and Hilary M. Lappin-Scott -- 13. Search for and Discovery of Microbial Enzymes from Thermally Extreme Environments in the Ocean / Jody W. Deming and John A. Baross -- 14. Molecular Methods for Assessing and Manipulating the Diversity of Microbial Populations and Processes / Søren J. Sørensen, Julia R. de Lipthay, Anne Kirstine Müller, Tamar Barkay, Lars H. Hansen, and Lasse Dam Rasmussen -- 15. Bioindicators and Sensors of Soil Health and the Application of Geostatistics / Ken Killham and William J. Staddon -- 16. Hydrolytic Enzyme Activities to Assess Soil Degradation and Recovery / Tom W. Speir and Des J. Ross -- 17. Enzymatic Responses to Pollution in Sediments and Aquatic Systems / Sabine Kuhbier, Hans-Joachim Lorch, and Johannes C.G. Ottow -- 18. Microbial Dehalogenation Reactions in Microorganisms / Lee A. Beaudette, William J. Staddon, Michael B. Cassidy, Marc Habash, Hung Lee, and Jack T. Trevors -- 19. Isolated Enzymes for the Transformation and Det6xification of Organic Pollutants / Liliana Gianfreda and Jean-Marc Bollag -- 20. Enzyme-Mediated Transformations of Heavy Metals/Metalloids: Applications in Bioremediation / Robert S. Dungan and William T. Frankenberger, Jr. -- 21. Enzymes in Soil: Research and Developments in Measuring Activities / M. Ali Tabatabai and Warren A. Dick.

"'Do no harm' a particularly leading and important phrase in the delivery of healthcare is not working. In fact depending on the epidemiological approach and which data sets one applies, medical errors, hospital acquired infections (HAIs) and pharmaceutical errors combined are the second or third leading killer of Americans annually: approximately 300,000 die from a combination of medical errors, hospital acquired infections (HAIs), and pharmaceutical errors...100,000 per category. Add to these numbers the hundreds of thousands who are harmed (morbidity) but not killed (mortality) changing quality of life and a substantial problem is defined"--Provided by publisher.

Preface -- Epidemic in Athens, 430-427 B.C.E. -- Malaria in ancient Rome -- Plague of the Antonines -- First plague pandemic, 541-747 -- Smallpox epidemic in Japan, 735-737 -- Leprosy in medieval Europe -- Second plague pandemic, 1346-1844 -- "French disease" in sixteenth-century Europe -- Epidemics in sixteenth-century America -- Epidemics and the Thirty Years' War, 1618-1648 -- Plague in Italian cities, 1630s -- Epidemics in China, 1640-1644 -- Plague in London, 1665 -- Smallpox in Iceland, 1707-1709 -- Plague in Marseilles, 1720-1722 -- Smallpox in Boston, 1721 -- Smallpox in eighteenth-century Europe -- Plague in Moscow, 1771 -- Influenza pandemic, 1781-1782 -- Yellow fever in Hispaniola, 1793-1804 -- Yellow fever in Philadelphia, 1793 -- First cholera pandemic, 1817-1824 -- Consumption in the nineteenth century -- Second cholera pandemic, 1827-1835 -- Third cholera pandemic, 1839-1856 -- "Fevers" and the great famine in Ireland, 1846-1850 -- Typhoid fever in cities, 1850-1920 -- Yellow fever in New Orleans, 1853 -- Fourth cholera pandemic, 1863-1875 -- Carrion's disease in Peru, 1870-1871 -- Smallpox in Europe, 1870-1875 -- Measles in Fiji, 1875 -- Fifth cholera pandemic, 1881-1896 -- Influenza pandemic, 1889-1890 -- Cholera epidemic in Hamburg, 1892 -- Third plague pandemic, 1894-? -- Sixth cholera pandemic, 1899-1923 -- Sleeping sickness in east central Africa, 1900-1905 -- Typhoid Mary's "epidemics" -- Cholera epidemic in Naples, 1910-1911 -- Poliomyelitis in the United States, 1916 -- Influenza pandemic, 1918-1919 -- Lung cancer in the United States, mid-twentieth century -- Poliomyelitis in the United States, 1945-1955 -- Seventh cholera pandemic, 1961-present -- Aids in the United States, 1980s -- Contemporary aids pandemic -- The mad cow crisis and transmissible spongiform encephalopathies, 1985-present -- Contemporary malaria -- Contemporary tuberculosis -- Epilogue -- Glossary.

The plague era - Modernity: new concepts of the state and the body -- Cholera: the return of epidemic disease and the abandonment of traditional protective measures -- The "English System:" new methods gain acceptance -- The sanitary reform movement: from miasma theory to departments of health -- Vaccination: a powerful paradigm -- The era of spectacular victories -- The end of a dream?

Early Concepts of Communicability --Infection on the Move --The Impact of Cholera --Stiffening the Sinews --Dawn and Sunset --A Need for Damage Limitation --No Lasting Stability --Tailpiece.

Medicine, science, and statistics -- Terms and concepts in medicine -- Epidemiological research proper -- Introductory terms and concepts -- Terms and concepts of objects of study -- Terms and concepts of methods of study -- Meta-epidemiological clinical research -- Introductory terms and concepts -- Terms and concepts of objects of study -- Terms and concepts of methods of study.

Defining and measuring drug abusing behaviors / Zili Sloboda -- Drug abuse heterogeneity and the search for subtypes / Meyer D. Glantz, Devin P. Conway and James D. Colliver -- Studying the natural history of drug use / Yih-Ing Hser ... [et al.] -- Health, social and psychological consequences of drug use and abuse / Michael D. Newcomb and Thomas Locke -- Use of archival data / Zili Sloboda, Rebecca McKetin and Nicholas J. Kozel -- Sampling issues in drug epidemiology / Colin Taylor and Paul Griffiths -- Collecting drug use data from different populations / Edward M. Adlaf -- Indirect methods to estimate prevalence / Matthew Hickman and Colin Taylor -- Qualitative methods in the drug abuse field / Claire E. Sterk and Kirk W. Elifson -- Ethical considerations for drug abuse epidemiologic research / Craig L. Fry and Wayne Hall --A common language for a common problems: the developing role of drug epidemiology in a global context / Paul Griffiths and Rebecca McKetin -- Longitudinal studies of drug use and abuse / Thomas A. Wills, Carmella Walker and Jody A. Resko -- Drug abuse and the spread of infection: HIV and AIDS as an example / Don C. Des Jarlais, Holly Hagan and Samuel R. Friedman -- Implications of epidemiologic information for effective drug abuse prevention strategies / Zili Sloboda -- The role of treatment data in studying the epidemiology of substance use and abuse / Robert L. Hubbard.

pt. 1. Individual sports -- pt. 2. Team sports.

Basic study designs in analytical epidemiology -- Measuring disease occurence -- Measuring associations between exposures and outcomes -- Understanding lack of validity: bias -- Identifying noncausal associations: confounding -- Defining and assessing heterogeneity of effects: interaction -- Stratification and adjustment: multivariate analysis in epidemiology -- Quality assurance and control -- Communicating results of epidemiologic studies -- Epidemiologic issues in the interface with public health policy.

Benign melanocytic proliferations -- Essential criteria for diagnosing melanoma -- Histologic mimics of malignant melanoma -- Epidermal neoplasms -- Pilosebaceous neoplasms -- Tumors with eccrine differentiation -- Merkel cell carcinoma.

Analysis of connexin 43 expression on keratinocytes using flow cytometry / Maja Matic ... [et al.] -- MMP-9 and TIMP-1 assays in keratinocyte cultures / Takashi Kobayashi -- Characterization of epithelial cells in the hair follicle with S100 proteins / Kenji Kizawa and Mayumi Ito -- Immunoelectron microscopic analysis of cornified cell envelopes and antigen retrieval / Akemi Ishida-Yamamoto -- Cell kinetic analysis in artificial skin using immunochemical methods / Andrea Casasco ... [et al.] -- Proliferation, differentiation, and inflammation in normal and hyperproliferative skin using multiparameter flow cytometry / Piet E.J. van Erp -- Fluorimetric DNA assay of cell number / William R. Otto -- Keratinocyte transient transfections / Anthony M. Flores and Brian J. Aneskievich -- Tetracycline-regulated gene expression in epidermal keratinocytes / Richard B. Presland and Philip Fleckman -- Gene targeting by oligonucleotides in keratinocytes / Olga Igoucheva and Kyonggeun Yoon --Epidermis-targeted gene transfer using in vivo electroporation / Hiroki Maruyama, Jun-Ichi Miyazaki and Fumitake Gejyo -- Gene and stem cell therapy of the hair follicle / Robert M. Hoffman.Isolation, characterization, and culture of epithelial stem cells / Jackie R. Bickenbach -- Keratin 19 as a stem cell marker in vivo and in vitro / Danielle Larouche ... [et al.] -- Immunolocalization in the epidermis / Tammy-Claire Troy ... [et al.] -- Epidermal cell analysis by RT-PCR / Tammy-Claire Troy ... [et al.] -- Whole-mount assays for gene induction and barrier formation in the developing epidermis / Carolyn Byrne and Matthew J. Hardman -- Analysis of early epidermal development in zebrafish / Ashley E. Webb and David Kimelman -- Analysis of E2F factors during epidermal differentiation / Wing Y. Chang and Lina Dagnino -- Analysis of HOX homeodomain proteins and gene transcripts in the epidermis / László G. Kömüves and Corey Largman -- Apoptosis in the epidermis / Kiyofumi Yamanishi, Chun-Shen Shen and Hitoshi Mizutani -- Fate of desmosomal proteins in apoptotic epidermal cells / Jörg Weiske and Otmar Huber --Primary mouse keratinocyte culture / Annalisa Pirrone, Barbara Hager, and Philip Fleckman -- Serial cultivation of primary adult murine keratinocytes / Richard P. Redvers and Pritinder Kaur -- Keratinocyte culture in the absence of substrate attachment / Monika Jost and Ulrich Rodeck -- Application of genetically modified feeder cells for culture of keratinocytes / Takashi Kameda and Toshihiro Sugiyama -- Organ culture of developing mouse skin and its application for molecular mechanistic studies of morphogenesis / Mariko Kashiwaga and Nam-ho Huh -- Experimental models to analyze differentiation functions of cultured keratinocytes in vitro and in vivo / Nicole Maas-Szabowski, Norbert E. Fusenig, and Hans-Jürgen Stark -- In vitro fabrication of engineered human skin / Alexander Margulis, Weitian Zhang and Jonathan A. Garlick -- In vivo labeling and analysis of epidermal stem cells / Wei-Yang Wu and Rebecca J. Morris -- Method for the harvest and assay of in vitro clonogenic keratinocytes stem cells from mice / Wei-Yang Wu and Rebecca J. Morris -- FACS enrichment of human keratinocyte stem cells / Amy Li and Pritinder Kaur --Promoter analysis in the human SPRR gene family / David F. Fischer and Claude Backendorf -- Stable integration of large PAC contructs in keratinocytes / Sarah H. Williams and Alain Hovnanian -- Targeted somatic mutagenesis in the mouse epidermis / Daniel Metzger, Mei Li, and Pierre Chambon -- Methods to study protein-protein interactions / Jin-Jun Meng ... [et al.] -- Isolation of recombinant phage-displayed antibodies recognizing skin keratinocytes / Kim Bak Jensen and Peter Kristensen -- Analysis of tissue-specific DNA methylation during development / Jun Ohgane, Naka Hattori and Kunio Shiota -- Serial analysis of gene expression in human keratinocytes and the epidermis / Bastiaan J.H. Jansen ... [et al.] -- Methods for gene expression profiling in dermatology research using DermArray® nylon filter DNA microarrays / Richard L. Davis Jr. ... [et al.] -- Two-photon fluorescence imaging and reactive oxygen species detection within the epidermis / Kerry M. Hanson and Robert M. Clegg -- In vivo transplantation of engineered human skin / Shari Greenberg, Alexander Margulis and Jonathan A. Garlick --

A historical perspective of EGF receptor and related systems / Francis Edwin ... [et al.] -- Purification and assay of kinase-active EGF receptor from mammalian cells by immunoaffinity chromatography / Gregory J. Wiepz ... [et al.] -- Soluble epidermal growth factor receptor acrydinium-linked immunosorbent assay / Jacqueline M. Lafky, Andre T. Baron, and Nita J. Maihle -- Analysis of epidermal growth factor receptor and interactions with the [alpha] subunit of the stimulatory GTP binding protein of adenylyl cyclase, Gs / Deepti Chaturvedi ... [et al.] -- Regulator of epidermal growth factor signaling : sprouty / Esther Sook Miin Wong and Graeme R. Guy -- Dissecting the epidermal growth factor signal transactivation pathway / Oliver M. Fischer, Stefan Hart, and Axel Ullrich -- A sensitive method to monitor ectodomain shedding of ligands of the epidermal growth factor receptor / Umut Sahin ... [et al.] -- In vitro and in vivo assays of monoubiquitnation of receptor tyrosine kinases / Manachem Katz, Yaron Mosesson, and Yosef Yarden -- Assays to monitor degradation of the EGF receptor / Mirko H.H. Schmidt and Ivan Dikic -- Assessment of degradation and ubiquitination of CXCR4, a GPCR regulated by EGFR family members / Adriano Marchese -- Epithelial cell migration in response to epidermal growth factor / Reema Zeineldin and Laurie G. Hudson -- Motility signaled from EGF receptors and related systems / Alan Wells ... [et al.] -- Methods for determining the proliferation of cells in response to EGFR ligands / Gregory J. Wiepz ... [et al.] -- Clinical advancement of EGFR inhibitors in cancer therapy / Prakash Chinnaiyan and Paul M. Harari.

Epigenetics and chronic diseases : an overview /Rebecca Smith, Jonathan Mill --Techniques to study DNA methylation and histone modification /Ester Lara ... [et al.] --Mechanisms of epigenetic gene silencing /Marie-Pierre Lambert, Zdenko Herceg --Mechanisms of epigenetic gene activation in disease : dynamics of DNA methylation and demethylation /Thierry Granbe, Edio Eligio Lourenco --The role of histone demethylases in disease /Paul Cloos --Autoimmune diseases /Travis Hughes, Amr H. Sawalha --Epigenetics of rheumatoid arthritis /Aleksander M. Grabiec, Paul P. Tak, Kris A. Reedquist --DNA methylation changes in osteoarthritis /Helmtrud I. Roach --Epigenetics and Type 2 diabetes /Charlotte Ling, Tina Ronn, Marloes Dekker Nitert --Epigenetic regulation of asthma and allergic diseases /Andrew L. Durham, Ivan M. Adcock --Epigenetics in psychiatry /Hamid Mostafavi-Abdolmaleky, Stephen J. Glatt, Ming T. Tsuang --Epigenetics and late-onset Alzheimer's disease /Axel Schumacher, Syed Bihaqi, Nasser H. Zawia --Epigenetic mechanisms in the developmental origins of adult disease /Keith M. Godfrey ... [et al.] --Targeting histone deacetylases in chronic obstructive pulmonary disease /Peter J. Barnes --Clinical trials of epigenetic modifiers in the treatment of myelodysplastic syndrome /Lauren C. Suarez, Steven D. Gore.

An introduction to epigenetics / Esteban Ballestar -- Chromatin mechanisms regulating gene expression in health and disease / Constanze Bonifer and Peter N. Cockerill -- Epigenetic control of lymphocyte differentiation / Eduardo Lopez-Granados -- Epigenetic control in immune function / Peter J. van den Elsen, Marja C.J.A. van Eggermond, and Rutger J. Wierda -- DNA methylation and B-cell autoreactivity / Soizic Garaud, Pierre Youinou, and Yves Renaudineau -- Environmental agents and autoimmune diseases / Frederick W. Miller -- Epigenetic dysregulation of Epstein-Barr virus latency and development of autoimmune disease / Hans Helmut Niller ... [et al.] -- Does genomic imprinting play a role in autoimmunity? / Cristina Camprubø and David Monk -- A new epigenetic challenge : systemic lupus erythematosus / Biola M. Javierre and Bruce C. Richardson -- Epigenetic deregulation in rheumatoid arthritis / Emmanuel Karouzakis ... [et al.] -- Prospects for epigenetic compounds in the treatment of autoimmune disease / Nadine Chapman-Rothe and Robert Brown -- Profiling epigenetic alterations in disease / Josø Ignacio Martøn-Subero and Manel Esteller.

Human epigenome -- Considerations in the design, conduct, and interpretation of studies in epigenetic epidemiology -- Laboratory methods in epigenetic epidemiology -- Biostatistical methods in epigenetic epidemiology -- Epigenome changes during development -- Role of epigenetics in the development origins of health and disease -- Epigenetics and assisted reproductive technology -- Imprinting disorders of early childhood -- Utility of twins for epigenetic analysis -- Age-related variation in DNA methylation -- Influence of environmental factors on the epigenome -- Epigenetic epidemiology of cancer -- Epigenetic epidemiology of infectious diseases -- Epigenetic epidemiology of inflammation and rhematoid arthritis -- Asthma epigenetics : emergnece of a new paradigm? -- Epigenetic epidemiology of autism and other neurodevelopmental disorders -- Epigenetic epidemiology psychiatric disorders -- Epigenetic epidemiology of type 1 diabetes -- Epigenetic epidemiology of obesity, type 2 diabetes -- Epigenetic epidemiology of atherosclerosis.

Epigenetic reprogramming and genomic imprinting -- Chromosome inactivation -- DNA methylation -- Histone modification and nucleosome structure -- Chromatin structure and dynamics -- Polycomb and related silencing mechanisms -- Nuclear organization and dynamics -- Heterochromatin and transposon silencing -- RNA interference and related mechanisms -- Epigenetic regulation of phenotypes.

Chromatin remodeling factors and DNA replication -- Epigenetic inheritance of chromatin states mediated by polycomb and trithorax group proteins in drosophila -- How to pack the genome for a safe trip -- Chromatin modifications on the inactive x chromosome -- Chromatin mechanisms in drosophila dosage compensation -- DNA methylation in epigenetic control of gene expression -- The epigenetic breakdown of cancer cells: from DNA methylation to histone modifications -- Developmental regulation of the beta-globin gene locus -- Epigenetic regulation of mammalian imprinted genes: from primary to functional imprints -- Seed development and genomic imprinting in plants.

Epigenetics and cancer: DNA methylation / Santiago Ropero and Manel Esteller -- Epigenetics and cancer: histone modifications / Mario F. Fraga and Manel Esteller -- Epigenetic drugs: DNA demethylating agents / Ehab Atallah, Guillermo Garcia-Manero -- Epigenetic drugs: histone deacetylase inhibitors / Melissa Peart, Ricky W. Johnstone -- Sirtuins in biology and disease / Alejandro Vaquero, Danny Reinberg -- MicroRNAs in cell biology and disease / Muller Fabbri, Carlo M. Croce, George A. Calin -- Chromatin modifications by polycomb complexes / Miguel Vidal -- Epigenetics and its genetic syndromes / Richard J. Gibbons -- Epigenetics and immunity / Esteban Ballestar and Bruce C. Richardson -- Aetiology of major psychosis: why do we need epigenetics? / Gabriel Oh and Arturas Petronis -- Epigenetics and cardiovascular disease / Gertrund Lund and Silvio Zaina -- Epigenetics and plant biology / Luis Valledor ... [et al.] -- Epigenetics, environment, and evolution / Douglas M. Ruden, Parsa Rasouli, Xiangyi Lu -- Epigenetics and epigenomics / Jose Ignacio Martin-Subero, Reiner Siebert.

Epigenetics of human disease / Trygve O. Tollefsbol -- Methods and strategies to determine epigenetic variation in human disease / Yoshihisa Watanabe and Masato Maekawa -- DNA methylation alterations in human cancers / Yae Kanai and Eri Arai -- Alterations of histone modifications in cancer / Ciro Mercurio, Simon Plyte and Saverio Minucci -- MicroRNA in oncogenesis / Niamh Lynam-Lennon, Steven G. Gray and Stephen G. Maher -- Epigenetic approaches to cancer therapy / Sabita N. Saldanha and Trygve O. Tollefsbol -- Epigenomics in neurobehavioral diseases / Cassandra L. Smith and Kai Huang -- Emerging role of epigenetics in human neurodevelopmental disorders / K. Naga Mohan and J. Richard Chaillet -- The epigenetics of Alzheimer's disease / Fabio Coppedè -- Epigenetic modulation of human neurobiological disorders / Takeo Kubota ... [et al.] --Epigenetic basis of autoimmune disorders in humans / Biola M. Javierre, Lorenza de la Rica and Esteban Ballestar -- Approaches to autoimmune disease using epigenetic therapy / Christopher Chang -- Epigenetic mechanisms of human imprinting disorders / Richard H. Scott and Gudrun E. Moore -- Epigenetic factors in human obesity / Christopher G. Bell -- Epigenetic approaches to control obesity / Abigail S. Lapham ... [et al.] -- Epigenetics of diabetes in humans / Charlotte Ling and Tina Rönn -- The potential of epigenetic compounds in treating diabetes / Steven G. Gray -- Epigenetic aberrations in human allergic diseases / Manori Amaraseka ... [et al.] -- Therapy of airway disease: epigenetic potential / Peter J. Barnes -- The role of epigenetics in cardiovascular disease / Boda Zhou, Andriana Margariti and Qingbo Xu -- Epigenetics and human infectious diseases / Hans Helmut Niller and Janos Minarovits -- The epigenetics of endometriosis / Sun-Wei Guo -- Aberrant DNA methlylation in endometrial cancer / Kenta Masuda ... [et al.] -- Stem cell epigenetics and human disease / Mehdi Shafa and Derrick E. Rancourt -- Non-coding RNA regulatory networks, epigenetics, and programming stem cell renewal and differentiation: implications for stem cell therapy / Rajesh C. Miranda -- Aging and disease: the epigenetic bridge / Andrea Fuso -- Early-life epigenetic programming of human disease and aging / Alexander M. Vaiserman.

Methods of epigenetic analysis / Trygve O. Tollefsbol -- Chromatin immunoprecipitation assays / Yan Yan, Haobin Chen, and Max Costa -- Native chromatin immunoprecipitation / Alan W. Thorne, Fiona A. Myers, and Tim R. Hebbes -- Q-PCR in combination with ChIP assays to detect changes in chromatin acetylation / Ryan A. Irvine and Chin-Lin Hsieh -- Restriction endonuclease accessibility as a determinant of altered chromatin structure / William M. Hempel and Pierre Ferrier -- Measuring changes in chromatin using micrococcal nuclease / Nicolas Steward and Hiroshi Sano -- DNasel hypersensitivity analysis of chromatin structure / Qianjin Lu and Bruce Richardson -- Inhibition of histone deacetylases / Cheng Liu and Dawei Xu -- Site-specific analysis of histone methylation and acetylation / David Umlauf, Yuji Goto, and Robert Feil -- Analysis of mammalian telomere position effect / Joseph A. Baur, Woodring E. Wright, and Jerry W. Shay -- Activity assays for poly-ADP ribose polymerase 1 / Eva Kirsten ... [et al.] -- Multigenerational selection and detection of altered histone acetylation and methylation patterns: toward a quantitative epigenetics in Drosophila / Mark D. Garfinkel ... [et al.] --Profiling DNA methylation by bisulfite genomic sequencing: problems and solutions / Liang Liu ... [et al.] -- Methylation-sensitive single-strand conformation analysis: a rapid method to screen for and analyze DNA methylation / Jean Benhattar and Geneviève Clément -- SIRPH analysis, SNuPE with IP-RP-HPLC for quantitative measurements of DNA methylation at specific CpG sites / Osman El-Maarri -- Real-time PCR-based assay for quantitative determination of methylation status / Ulrich Lehmann and Hans Kreipe -- Denaturing gradient gel electrophoresis to detect methylation changes in DNA / Masahiko Shiraishi -- Photocrosslinking oligonucleotide hybridization assay for concurrent gene dosage and CpG methylation analysis / Risa Peoples, Michael Wood, and Reuel Van Atta -- Methylation-specific oligonucleotide microarray / Pearlly S. Yan, Susan H. Wei, and Tim Hui-Ming Huang -- Methylation-specific PCR in situ hybridization / Gerard J. Nuovo -- Relative quantitation of DNA methyltransferase mRNA by real-time RT-PCR assay / John Attwood and Bruce Richardson -- DMB (DNMT-magnetic beads) assay: measuring DNA methyltransferase activity in vitro / Tomoki Yokochi and Keith D. Robertson.

Section I. Scientific Foundations -- Chapter 1. Pathophysiological Mechanisms of Seizures and Epilepsy / Carl E. Stafstrom -- Chapter 2. Blood-Brain Barrier, Blood Flow, Neoplasms and Epilepsy / Luca Cucullo, Nicola Marchi, Vincent Fazio, Minh-Tri Nguyen, Damir Janigro -- Chapter 3. Metabolic Regulation of Seizures and Epileptogenesis / Manisha Patel -- Chapter 4. Brain Inflammation and Epilepsy / Teresa Ravizza, Silvia Balosso, Eleonora Aronica, Annamaria Vezzani -- Chapter 5. Drug Resistance in Epilepsy and Status Epilepticus / Jaideep Kapur, Edward H. Bertram -- Chapter 6. Epilepsy with Complex Genetics / Asuri N. Prasad, Chitra Prasad -- Chapter 7. Pathophysiology of Developmental Epilepsies / Judith L. Z. Weisenberg, Michael Wong -- Section II. Antiepileptic Drugs -- Chapter 8. Mechanisms of Antiepileptic Drug Action / Timothy A. Simeone -- Chapter 9. Epilepsy and Disease Modification: Animal Models for Novel Drug Discovery / H. Steve White -- Chapter 10. Pharmacogenetics of AED Development / Russell J. Buono, Thomas N. Ferraro, Dennis J. Dlugos, Karen S. Wilcox -- Chapter 11. Neuroprotective Strategies Using Antiepileptic Drugs / Patrick G. Sullivan, Ryan D. Readnower -- Chapter 12. Posttraumatic Seizures and Epileptogenesis / Christopher C. Giza -- Chapter 13. Possible Roles of Nonsynaptic Mechanisms in Synchronization of Epileptic Seizures / F. Edward Dudek, Li-Rong Shao, John E. Rash -- Chapter 14. A Mechanistic Approach to Antiepileptic Drug Interactions / Gail D. Anderson -- Section III. Epilepsy Surgery -- Chapter 15. Advances in Structural and Functional Neuroimaging / Hyunmi Kim, A. LeBron Paige, Robert C. Knowlton -- Chapter 16. Magnetoencephalography in Clinical Epilepsy / Jerry J. Shih, Michael P. Weisend -- Chapter 17. What Have We Learned from Resective Surgery in Pediatric Patients with Cortical Dysplasia? / Carlos Cepeda, Gary W. Mathern -- Chapter 18. Nonsurgical Ablation for Epilepsy / Erich O. Richter, Marina V. Abramova, William A. Friedman, Steven N. Roper -- Chapter 19. Deep Brain Stimulation for Epilepsy / Francisco Velasco, Ana Luisa Velasco, Luisa Rocha, Marcos Velasco, Jose D. Carrillo-Ruiz, Manoela Cuellar, Guillermo Castro, Fiacro Jimenez, David Trejo -- Chapter 20. Optical Imaging Techniques in Pediatric Neocortical Epilepsy / Daryl W. Hochman, Michael M. Haglund -- Chapter 21. High-Frequency Oscillations in Epileptic Brain / S. Matt Stead, Mark Bower, Greg Worrell -- Section IV. Alternative Therapies -- Chapter 22. Special Treatments in Epilepsy / Kevin Chapman, James W. Wheless -- Chapter 23. Herbs and Botanicals Steven C. Schachter -- Chapter 24. The Ketogenic Diet / Kristopher J. Bough, Carl E. Stafstrom -- Chapter 25. Vagus Nerve Stimulation / Matthew M. Troester, Dean K. Naritoku -- Chapter 26. Antiinflammatory Treatments for Seizure Syndromes and Epilepsy / Stéphane Auvin, Raman Sankar -- Section V. Other Modulators of the Epileptic State -- Chapter 27. Impact of Neuroendocrine Factors on Seizure Genesis and Treatment / Pavel Klein, Jaromir Janousek -- Chapter 28. Neurosteroid Replacement Therapy for Catamenial Epilepsy / Doodipala S. Reddy, Michael A. Rogawski -- Chapter 29. Chronobiology and Sleep / Mark Quigg -- Chapter 30. Pediatric Epilepsy / Rochelle Caplan -- Section VI. The Future of Epilepsy Therapy -- Chapter 31. Novel Mechanisms of Drug Delivery / Vijay Ivaturi, James Cloyd -- Chapter 32. Early Seizure Detection / Christophe C. Jouny, Piotr J. Franaszczuk, Gregory K. Bergey -- Chapter 33. Gene and Stem Cell Therapies for Treating Epilepsy / Janice R. Naegele, Xu Maisano -- Chapter 34. Arresting Epileptogenesis / Philip A. Schwartzkroin.

"Integrating the studies of epilepsy, neurosciences, computational neurosciences, mathematics, physics, engineering, and medicine, this volume provides the first means to a clear, structured, and enriching multidisciplinary perspective for developing students, researchers, and clinicians in the field of epilepsy. The text gives up to date information on the state of current research, possible future research, and clinical directions in the fields of epilepsy and seizure dynamics. Clear illustrations that illustrate the patterns of brain electrophysiology and behavioral manifestations are provided to aid comprehension. The authors include extensive references in each chapter to enhance further study"--Provided by publisher.

pt. 1. Basic principles and diagnosis -- pt. 2. Treatment.

EEG generation and measurement -- Signal processing in EEG analysis -- Classifying the EEG -- Seizure detection -- Modeling for epilepsy -- On the predictability of seizures.

What is a B-cell epitope? / Marc H.V. Van Regenmortel -- Structural basis of antibody-antigen interactions / Eric J. Sundberg -- Epitope mapping of antibody-antigen complexes by nuclear magnetic resonance spectroscopy / Osnat Rosen and Jacob Anglister -- A solid-phase mutual inhibition assay with labeled antigen / Masahide Kuroki -- Epitope mapping by surface plasmon resonance / Pär Säfsten -- Proteolytic fragmentation for epitope mapping / Maria R. Mazzoni, Francesca Porchia, and Heidi E. Hamm -- Epitope mapping by proteolysis of antigen-antibody complexes / Suraj Dhungana ... [et al.] -- Identifying residues in antigenic determinants by chemical modification / Howard M. Reisner and Roger L. Lundblad -- Epitope mapping by differential chemical modification of antigens / Suraj Dhungana, Michael B. Fessler, and Kenneth B. Tomer -- Linear B-cell epitope mapping using enzyme-linked immunosorbent assay for libraries of overlapping synthetic peptides / Michael W. Heuzenroeder ... [et al.] -- Antibody epitope mapping using SPOT peptide arrays / Ulrich Reineke and Robert Sabat -- Peptide microarrays for profiling of modification state-specific antibodies / Johannes Zerweck, Antonia Masch, and Mike Schutkowski -- Epitope mapping using phage display peptide libraries / Volker Böttger and Angelika Böttger -- Antibody epitope mapping using de novo generated synthetic peptide libraries / Ulrich Reineke -- Antibody specificity profiling on functional protein microarrays / Dawn R. Mattoon and Barry Schweitzer -- Peptide microarrays for determination of cross-reactivity / Alexandra Thiele -- Epitope mapping using randomly generated peptide libraries / Juliane Bongartz, Nicole Bruni, and Michal Or-Guil -- Probing the epitope signatures of IgG antibodies in human serum from patients with autoimmune disease / Peter Lorenz ... [et al.] -- Microarrayed allergen molecules for diagnostics of allergy / Jing Lin, Ludmilla Bardina, and Wayne G. Shreffler -- Monitoring B cell response to immunoselected phage-displayed peptides by microarrays / Lina Cekaite, Eiving Hovig, and Mouldy Sioud -- Epitope mapping using homolog-scanning mutagenesis / Lin-Fa Wang -- Epitope mapping by region-specified PCR-mutagenesis / Tsutomu Mikawa, Masayuki Ikeda, and Takehiko Shibata -- Epitope mapping using phage-display random fragment libraries / Lin-Fa Wang and Meng Yu -- Prediction of linear B-cell epitopes / Ulf Reimer -- Molecular recognition of diverse ligands by T-cell receptors / Eric J. Sundberg -- Identification of human MHC class I binding peptides using the iTOPIA epitope discovery system / Markus Wulf, Petra Hoehn, and Peter Trinder -- T-cell epitope mapping in Mycobacterium tuberculosis using PepMixes created by micro-scale SPOT synthesis / Marisa Frieder and David M. Lewinsohn -- High-throughput T-cell epitope discovery through MHC peptide exchange / Sine Reker Hadrup ... [et al.] -- T-cell epitope processing (the epitope flanking regions matter) / Alejandra Nacarino Martinez, Stefan Tenzer, and Hansjörg Schild -- Identification of MHC class II binding peptides : microarray and soluble MHC class II molecules / Simani Gaseitsiwe and Markus J. Maeurer -- T-cell epitope mapping / Raija K.S. Ahmed and Markus J. Maeurer -- Identification and validation of T-cell epitopes using the IFN-[gamma] EliSpot assay / Markus Wulf, Petra Hoehn, and Peter Trinder.

Ecological ergonomics / Marvin J. Dainoff -- Integrating cognitive and digital human models for virtual product design / Daniel W. Carruth and Vincent G. Duffy -- Time study during vocational training / Gregory Z. Bedny and Waldemar Karwowski -- The laws of ergonomics applied to design and testing of workstations / V.F. Venda, V.K. Kalin, and A.Y. Trofimov -- Day-to-day monitoring of an operator's functional state and fitness-for-work : a psychophysiological and engineering approach / Oleksandr Burov -- Identification of mental modules ; Identification of neural modules / Saul Sternberg -- The new interface of brain, mind, and machine : will the emergent whole be greater than the sum of the parts? / Chris Berka ... [et al.] -- The interaction of sleep and memory / Jeffrey M. Ellenbogen -- Attention, selection for action, error processing, and safety / Magdalena Fafrowicz and Tadeusz Marek -- Activity theory : comparative analysis of Eastern and Western approaches / Waldemar Karwowski, Gregory Z. Bedney, and Olexiy Y. Chebykin -- Discourse in activity / Harry Daniels -- Movements of the cane prior to locomotion judgments : the informer fallacy and the training fallacy versus the role of exploration / Gregory Burton and Jennifer Cyr -- Emotional intelligence : a novel approach to operationalizing the construct / E.L. Nosenko -- Emotional regulation of the learning process / Olexiy Y. Chebykin and S.D. Maksymenko -- Emotional resources of the professional trainer / G.V. Lozhkin -- Good judgment : the intersection of intelligence and personality / Robert Hogan, Joyce Hogan and Paul Barrett -- Relational self in action : relationships and behavior / Susan E. Cross and Kari A. Terzino.

Posture and movement -- Information and operation -- Environmental factors -- Work organization jobs and tasks -- The ergonomic approach -- Sources of additional information.

1. History and Biology of Erythropoietin in Hematopoietic and Non-Neural Tissues / Giorgia Melli, Sanjay Keswani and Ahmet Höke, p. 1-13 -- 2. Expression of Erythropoietin and Its Receptor in the Central Nervous System / Hugo Marti and Christian Bauer, p. 15-31 -- 3. Erythropoietin and Neuroprotection in the Central Nervous System: Intracellular Signaling Pathways / Murat Digicaylioglu, p. 33-48 -- 4. Regulation of Erythropoietin Expression in the Nervous System: The Hypoxia Inducible Factor / Juan Chavez and JoAnn Gensert, p. 49-67 -- 5. Erythropoietin Neuroprotection in the Term and Preterm Infant: Safety and Efficacy / Eric Demers and Sandra Juul, p. 69-98 -- 6. Erythropoietin for the Treatment of Acute Ischemic Stroke: Preclinical Rationale / Michael Renzi, Linda Jolliffe, Francis Farrell and Kenneth Rhodes, p. 99-112 -- 7. Erythropoietin Neuroprotection in the Retina / Gundula Rohde, Mathias Bähr and Jochen Weishaupt, p. 113-126 -- 8. Erythropoietin for Treatment of Human Brain Disease: Experience from Proof-of-Concept Trials / Hannelore Ehrenreich and Anna-Leena Sirén, p. 127-145 -- 9. Erythropoietin in Spinal Cord Injury Challenges for a Novel Neuroprotective Strategy / Michael Brines and Anthony Cerami, p. 147-164 -- 10. Erythropoietin and Neuroprotection in the Peripheral Nervous System: In Vivo Studies / W. Campana, p. 165-177 -- 11. An Endogenous Pathway Preventing Axonal Degeneration Mediated by Schwann Cell-Derived Erythropoietin / Sanjay Keswani and Ahmet Höke, p. 179-190 -- 12. Role of Erythropoietin in Inflammatory Pathologies of the CNS/ Pietro Ghezzi, Paolo Bigini and Manuela Mengozzi, p. 191-209 -- 13. Development of Non-Erythropoietic Erythropoietin Variants for Neuroprotection / Lars Torup and Marcel Leist, p. 211-219.

Erythropoiesis: an overview / B.E. Torbett and J.S. Friedman -- Regulation of endogenous erythropoietin production / D.R. Mole and P.J. Ratcliffe -- Biology of erythropoietin / G. Molineux and A.M. Sinclair -- Erythropoiesis - genetic abnormalities / J.T. Prchal and X.T. Gregg -- Studies of erythropoiesis and the discovery and cloning of recombinant human erythropoietin / M.A. Foote -- Commercial production of recombinant erythropoietins / A.S. Chuck ... [et al.] -- Biosimilar epoetins / H. Schellekens -- New molecules and formulations / S.G. Elliott -- Structural basis for the signal transduction of erythropoietin / T.D. Osslund -- Intracellular signaling by the erythropoietin receptor / H.F. Lodish ... [et al.] -- Mechanism of erythropoietin receptor activation / S.N. Constantinescu -- Pharmacokinetics of erythropoiesis-stimulating agents / S. Doshi ... [et al.] -- Use of erythropoietic stimulating agents in the setting of renal disease / D.A. Goodkin -- Abuse of recombinant erythropoietins and blood products by athletes / D.H. Catlin and C.K. Hatton -- Role and regulation of iron metabolism in erythropoiesis and disease / T.L. Arvedson and B.J. Sasu -- Nonhematopoietic effects of erythropoiesis-stimulating agents / W. Jelkmann, R. Depping and E. Metzen.

Cardiovascular Disease Prevention in Clinical Practice 2007 Fourth Joint European Societies' Task Force on Cardiovascular Disease Prevention in Clinical Practice -- -- Arterial Hypertension 2007 ESH-ESC Task Force on the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC) -- Diabetes, Pre-diabetes and Cardiovascular Diseases 2007 The Task Force on Diabetes and Cardiovascular Diseases of the European Society of Cardiology (ESC) and of the European Association for the Study of Diabetes (EASD) -- Non-ST-segment Elevation Acute Coronary Syndromes 2007 The Task Force for the Diagnosis and Treatment of Non-ST-Segment Elevation Acute Coronary Syndromes of the European Society of Cardiology -- AMI in Patients Presenting with Persistent ST-Segment Elevation 2008 The Task Force on the Management of ST-Segment Elevation Acute Myocardial Infarction of the European Society of Cardiology -- Stable Angina Pectoris 2006 The Task Force on the Management of Stable Angina Pectoris of the European Society of Cardiology -- Myocardial Revascularisation 2011 Joint Task Force on Myocardial Revascularisation of the European Society of Cardiology (ESC) and the European Association of Cardio-Thoracic Surgery (EACTS). Developed with the special contribution of the European Association for Percutaneous Cardiovascular Interventions (EAPCI) -- Hypertrophic Cardiomyopathy 2003 The Task Force on Hypertrophic Cardiomyopathy of the American College of Cardiology Foundation and the European Society of Cardiology Committee for Practice Guidelines -- Pericardial Diseases 2004 The Task Force on the Diagnosis and Management of Pericardial Disease of the European Society of Cardiology -- Grown-up congenital heart disease 2011 The Task Force on the Management of Grown-up Congenital Heart Disease of the European Society of Cardiology (ESC). Endorsed by Association for European Paediatric Cardiology (AEPC) -- Neonatal Electrocardiogram 2002 The Task Force for the interpretation of the Neonatal Electrocardiogram of the European Society of Cardiology -- Cardiovascular Disease during Pregnancy 2003 The Task Force on the Management of Cardiovascular Diseases during Pregnancy of the European Society of Cardiology --Valvular Heart Disease 2007 The Task Force on the Management of Valvular Heart Disease of the European Society of Cardiology -- Infective Endocarditis 2009 The Task Force on the Prevention, Diagnosis and Treatment of Infective Endocarditis of the European Society of Cardiology (ESC), endorsed by the European Society of Clinical Microbiology, Infectious Diseases (ESCMID) and by the International Society of Chemotherapy (ISC) for Infection and Cancer -- Pulmonary Hypertension 2009 The Task Force for the Diagnosis and Treatment of Pulmonary Hypertension of the European Society of Cardiology (ESC) and the European Respiratory Society (ERS), endorsed by the International Society of Heart and Lung Transplantation (ISHLT) and by the Association for European Paediatric Cardiology (AEPC) -- Supraventricular Arrhythmias (SVA) 2003 A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and the European Society of Cardiology Committee for Practice Guidelines (Writing Committee to Develop Guidelines for the Management of Patients with Supraventricular Arrhythmias) -- Atrial Fibrillation 2010 The Task Force for the Management of Patients with Atrial Fibrillation (2010 Version) of the European Society of Cardiology (ESC) Developed with the special contribution of the European Heart Rhythm Association Endorsed by the European Association for Cardio-Thoracic Surgery (EACTS) -- Syncope 2009 The Task Force for the Diagnosis and Treatment of Syncope of the European Society of Cardiology (ESC) Developed in collaboration with the European Heart Rhythm Association (EHRA)¹, the Heart Failure Association (HFA)² and the Heart Rhythm Society (HRS)³ Endorsed by the following societies: European Society of Emergency Medicine (EuSEM)⁴, European Federation of Internal Medicine (EFIM)⁵, European Union Geriatric Medicine Society (EUGMS)⁶, American Geriatrics Society (AGS), European Neurological Society (ENS)⁷, American Autonomic Society (AAS)⁸, European Federation of Autonomic Societies (EFAS)⁹ -- Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death 2006 A Report of the American College of Cardiology/American Heart Association Task Force and the European Society of Cardiology Committee for Practice Guidelines (Writing Committee to Develop Guidelines for the Management of Patients With Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death) Developed in Collaboration With the European Heart Rhythm Association and the Heart Rhythm Society -- Cardiac Pacing and Cardiac Resynchronization Therapy 2007 ESC Task Force on Cardiac Pacing and Cardiac Resynchronization Therapy Developed in collaboration with the European Heart Rhythm Association -- Universal Definition of Myocardial Infarction 2007 The joint ESC-ACCF-AHA-WHF Task Force for the Redefinition of Myocardial Infarction -- Acute and Chronic Heart Failure 2008 The Task Force on Heart Failure of the European Society of Cardiology (ESC) Developed in collaboration with the Heart Failure Association of the ESC (HFA) -- Device Therapy in Heart Failure 2011 The Task Force for an update of the 2008 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure and the 2007 ESC Guidelines for cardiac resynchronization therapy. Developed with the special contribution of the Heart Failure Association (HFA) and the European Heart Rhythm Association (EHRA) of the ESC -- Preoperative Cardiac Risk Assessment and Perioperative Cardiac Management in Non-Cardiac Surgery 2009 The Task Force for Preoperative Cardiac Risk Assessment and Perioperative Cardiac Management in Non-Cardiac Surgery of the European Society of Cardiology (ESC), endorsed by the European Society of Anaesthesiology (ESA).

The genomes of Escherichia coli K-12 and pathogenic E. coli / Nicole T. Perna, Jeremy D. Glasner, Valerie Burland and Guy Plunkett III -- Evolution of pathogenic Escherichia coli / James R. Johnson -- Enteropathogenic Escherichia coli / T. Eric Blank, Jean-Philippe Nougayrède and Michael S. Donnenberg -- Enterohemorrhagic and other shiga toxin-producing Escherichia coli / Cheleste M. Thorpe, Jennifer M. Ritchie and David W.K. Acheson -- Enterotoxigenic Escherichia coli / Eric A. Elsinghorst -- Enteroaggregative and diffusely adherent Escherichia coli / James P. Nataro and Theodore Steiner -- Shigella and enteroinvasive Escherichia coli : paradigms for pathogen evolution and host-parasite interactions / William A. Day and Anthony T. Maurelli -- Uropathogenic Escherichia coli / Farah Bahrani-Mougeot, Nereus W. Gunther IV, Michael S. Donnenberg and Harry L.T. Mobley -- Meningitis-associated Escherichia coli / Kwang Sik Kim -- Adhesive pili of the Chaperone-Usher family / James G. Bann, Karen W. Dodson, Carl Frieden and Scott J. Hultgren -- Type IV pili / W. Schreiber and Michael S. Donnenberg -- The LEE-encoded Type III secretion system in EPEC and EHEC : assembly, function, and regulation / J. Adam Crawford, T. Eric Blank and James B. Kaper -- Hemolysin / Vassilis Koronakis and Colin Hughes -- Capsule and lipopolysaccharide / Thomas A. Russo.

General concepts in column chromatography -- The column in gas chromatography -- Instrumental aspects of gas chromatography -- The column in liquid chromatography -- Instrumental aspects of liquid chromatography -- Thin-layer chromatography -- Supercritical fluid chromatography -- Capillary-electromigration separation techniques -- Spectroscopic detectors for identification and quantification -- Separation of stereoisomers -- Laboratory-scale preparative chromatography.

Introduction to the Art of Communication, p. 1-8 -- Part I. The Written Document: Prose and Panic -- ch. 1. Planning the Document, p. 11-24 -- ch. 2. Acquiring a Healthy Writing Attitude, p. 25-33 -- ch. 3. Producing the Document, p. 35-46 -- Part II. The Formal Presentation: Dissertation or Disaster -- ch. 4. Planning the Presentation, p. 51-69 -- ch. 5. Acquiring the Successful Presentation Attitude, p. 71-79 -- ch. 6. Conducting the Presentation, p. 81-89 -- Part III. The Informal Discussion: Meetings and Mishaps -- ch. 7. Planning for the Meeting, p. 93-103 -- ch. 8. Acquiring a Meeting Attitude, p. 105-110 -- ch. 9. Participating in the Meeting, p. 111-119 -- Part IV. Cross-Culture Communication: Bridging the Gap -- ch. 10. Understanding a Communication Culture Gap, p. 125-136 -- ch. 11. Writing for any Group of Readers, p. 137-149 -- ch. 12. Presenting to Any Audience, p. 151-162 -- ch. 13. Meeting with Anyone or Any Group, p. 163-173 -- ch. 14. Conclusion, p. 17.

Introduction to biological databases -- Pairwise sequence alignment -- Database similarity searching -- Multiple sequence alignment -- Profiles and hidden Markov models -- Protein motifs and domain prediction -- Gene prediction -- Promoter and regulatory element prediction -- Phylogenetics basics -- Phylogenetic tree construction methods and programs -- Protein structure basics -- Protein structure visualization, comparision, and classification -- Protein secondary structure prediction -- Protein tertiary structure prediction -- RNA structure prediction -- Genome mapping, assembly, and comparison -- Functional genomics -- Proteomics.

Multivariable evaluation of candidates for cardiovascular disease / William B. Kannel -- Molecular and cellular basis of myocardial contractility / Arnold M. Katz -- Ventricular function / Lionel H. Opie -- Vascular function / Clive Rosendorff -- Thrombosis / Yale Nemerson and Mark B. Taubman -- The medical history and symptoms of heart disease / H.J.C. Swan -- Physical examination of the heart and circulation / Jonathan Abrams -- Electrocardiography / Tara L. DiMino ... [et al.] -- Echocardiography / Daniel G. Blanchard and Anthony N. DeMaria -- Exercise testing / Gregory Engel and Victor Froelicher -- Radiology of the heart / Gautham P. Reddy and Robert M. Steiner -- Cardiac catheterization and coronary angiography / Mark J. Ricciardi, Nirat Beohar, and Charles J. Davidson --Nuclear imaging in cardiovascular medicine / Diwakar Jain and Barry L. Zaret -- Cardiovascular magnetic resonance and x-ray computed tomography / Gerald M. Pohost ... [et al.] -- Choosing appropriate imaging techniques / Jonathan E. E. Fisher and Martin E. Goldman -- Electrophysiology of cardiac arrhythmias / Sei Iwai ... [et al.] -- Treatment of cardiac arrhythmias / Davendra Mehta -- Syncope / Fei Lü, Scott Sakaguchi, and David G. Benditt -- Pathophysiology of heart failure / Mark Scoote, Ian F. Purcell, and Philip A. Poole-Wilson -- Treatment of congestive heart failure / Stephen S. Gottlieb -- Congenital heart disease / Julien I.E. Hoffman --Pathogenesis of atherosclerosis / Prediman K. Shah -- Risk factors and prevention, including hyperlipidemias / Antonio M. Gotto, Jr. and John Farmer -- Coronary blood flow and myocardial ischemia / Robert J. Henning and Ray A. Olsson -- Stable angina / Satya Reddy Atmakuri, Michael H. Gollob, and Neal S. Kleiman -- Unstable angina and non-ST segment elevation myocardial infarction (acute coronary syndromes) / Satya Reddy Atmakuri and Neal S. Kleiman -- ST segment elevation myocardial infarction / Rajat Deo, Christopher P. Cannon, and James A. de Lemos -- Cardiopulmonary resuscitation / Joseph P. Ornato -- Rehabilitation after acute MI / Fredric J. Pashkow -- Rheumatic fever and valvular heart disease / Edmund A.W. Brice and Patrick J. Commerford -- Infective endocarditis / Adolf W. Karchmer -- Hypertension: mechanisms and diagnosis / Clive Rosendorff -- Hypertension therapy / Norman M. Kaplan -- Cardiomyopathies and myocarditis / Edward K. Kasper -- Pericardial disease / David H. Spodick --Pulmonary vascular disease / Dermot O'Callaghan and Sean P. Gaine -- Diseases of the aorta / Eric M. Isselbacher -- Pregnancy and cardiovascular disease / Samuel C.B. Siu and Jack M. Colman -- Heart disease in the elderly / Michael W. Rich -- Cardiovascular complications in patients with renal disease / Richard A. Preston, Simon Chakko, and Murray Epstein -- Assessment of patients with heart disease for fitness for noncardiac surgery / Joseph Savino and Lee A. Fleisher -- Cardiovascular gene and cell therapy / Eddy Kizana ... [et al.] -- Preventive cardiology / Michael Miller -- Peripheral arterial disease / James J. Jang and Jonathan L. Halperin.

v. 1. Cell structure -- v. 2. Cell function.

Toxicogenomics and classical toxicology, how to improve prediction and mechanistic understanding of human toxicity / Donna L. Mendrick -- Use of traditional endpoints and gene dysregulation to understand mechanisms of toxicity / Wayne R. Buck, Jeffrey F. Waring, Eric A. Blomme -- Quality control of microarray assays for toxicogenomic and in vitro diagnostic applications / Karol L. Thompson and Joseph Hackett -- Role of statistics in toxicogenomics / Michael Elashoff -- Predictive toxicogenomics in preclinical discovery / Scott A. Barros and Rory B. Martin -- In vivo predictive toxicogenomics / Mark W. Porter -- Bioinformatics, databasing and gene annotation / Lyle D. Burgoon and Timothy R. Zacharewski -- Microarray probe mapping and annotation in cross - species comparative toxicogenomics / John N Calley, William B Mattes, Timothy P. Ryan -- Toxicogenomics in biomarker discovery -- Marc F. DeCristofaro, Kellye K. Daniels -- From pharmacogenomics to translational biomarkers / Donna L. Mendrick -- Public consortium efforts in toxicogenomics / William B. Mattes -- Applications of toxicogenomics to nonclinical drug development / Frank D. Sistare, Joseph J. DeGeorge.

Echocardiographic instumentation and principles of doppler echocardiography / Scott D. Solomon -- Introduction to imaging: the normal examination / Dara Lee and Scott D. Solomon -- Protocol and nomenclature in transthoracic echocardiography / Bernard E. Bulwer and Jose Rivero -- Clinical utility of echocardiography / Bernard E. Bulwer, Faisal Shamshad, and Scott D. Solomon -- Echocardiographic assessment of ventricular systolic function / Bernard E. Bulwer, Scott D. Solomon, and Rajesh Janardhanan -- Echocardiographic assessment of diastolic function / Carolyn Y. Ho -- Echocardiography in myocardial infarction / Justina C. Wu -- Stress echocardiography : indications, protocols, and interpretation / Edmund A. Bermudez and Ming Hui Chen -- Cardiomyopathies / Bernard E. Bulwer and Scott D. Solomon -- Pericardial disease / Ashvin N. Pande and Leonard S. Lilly -- Echocardiographic assessment of aortic stenosis / Edmund A. Bermudez -- Echocardiographic evaluation of aortic regurgitation / Susan M. Sallach and Sharon C. Reimold -- Mitral stenosis / Robert J. Ostfeld -- Mitral regurgitation / Jacqueline Suk Danik and Bernard E. Bulwer -- Infective endocarditis / Nagesh S. Anavekar, Marcus Averbach, and Bernard E. Bulwer -- Role of echocardiography in the management of atrial fibrillation / Warren J. Manning -- Cardiac source of embolus / Justina C. Wu -- Echocardiography in pulmonary embolism and secondary pulmonary hypertension / David Aguilar and Bernard E. Bulwer -- Cardiac masses and tumors / Justina C. Wu -- Aortic dissection and other diseases of the aorta / Laura Benzaquen -- Echocardiography in the assessment of artrial septal defects / Edmund A. Bermudez -- Adult congenital heart disease in general echocardiography practice : an introduction / Bernard E. Bulwer and Michael J. Landzberg -- Transesophageal echocardiography multiplane examination primer / Bernard E. Bulwer and Stanton K. Shernan.

The endocrine system -- The biological principles of endocrinology -- The molecular basis of endocrinology -- Investigations in endocrinology -- The hypothalamus and pituitary gland -- The adrenal gland -- Reproductive endocrinology -- The thyroid gland -- Calcium and metabolic bone disease -- Endocrine neoplasia -- Overview of diabetes -- Type 1 diabetes -- Type 2 diabetes -- Complications of diabetes -- Obesity.

The genetic code of genes and genomes -- Transmission genetics: heritage from Mendel -- The chromosomal basis of heredity -- Gene linkage and genetic mapping -- Human chromosomes and chromosome behavior -- DNA structure, replication, and manipulation -- The genetics of bacteria and their viruses -- The molecular genetics of gene expression -- Molecular mechanisms of gene regulation -- Genomics, proteomics, and genetic engineering -- The genetic control of development -- Molecular mechanisms of mutation and DNA repair -- Molecular genetics of the cell cycle and cancer -- Molecular evolution and population genetics -- The genetic basis of complex inheritance.

Part I. Upper Respiratory Tract Infections -- 1. Clinical guidelines: community acquired pneumonia / John Russell -- 2. Pharyngitis / Adrian Wilson -- 3. Treatment and management of acute otitis media / Ross H. Albert and Neil S. Skolnik -- 4. Management of chronic obstructive pulmonary disease exacerbations and acute bronchitis / Michael Gagnon -- 5. Latent tuberculosis infection: testing and treatment / Pamela Ann Fenstemacher -- 6. Sinusitis / Megan Werner and Mathew Clark -- Part II. Gastrointestinal Infections -- 7. Gastroenteritis / Andrew Deroo and Matthew Mintz -- 8. Hepatitis / Michele Lamoreux -- III. Sexually Transmitted Diseases -- 9. Sexually transmitted diseases / Neil Skolnik -- 10. Human immunodeficiency virus / Rosemary Harris -- IV. Skin, Bone, and Joint Infection -- 11. Cellulitis and skin infections associated with bites / Steven Zinn and Judith O'Donnell -- 12. Diabetic foot infections / Thomas C. McGinley Jr. -- 13, Osteomyelitis / Kelly Gannon and Todd Braun -- 14. Septic arthritis and infectious bursitis / Gene Hong and Nirandra Mahamitra -- 15. Lyme disease prevention, diagnosis, and treatment / Ross Albert and Neil Skolnik -- V. Other Infectious Disease Topics -- 16. Infective endocarditis / Tina Degnan and Neil Skolnik -- 17. Meningitis / Anne T. Wiedemann -- 18. Urinary tract infections / Jennifer Neria and Matthew Mintz -- 19. Adult immunizations / John Russell and Ross Albert -- 20. Clinical ethics and infectious disease in family medicine / Janet Fleetwood.

Using this book -- Defining the data -- Displaying the data -- Means, standard deviations and standard errors -- The normal distribution -- Confidence interval for a mean -- Comparison of two means: confidence intervals, hypothesis tests and P-values -- Using P-values and confidence intervals to interpret the results of statistical analyses -- Comparison of means from several groups: analysis of variance -- Linear regression and correlation -- Multiple regression -- Goodness of fit and regression diagnostics -- Transformations -- Probability, risks and odds (of disease) -- Proportions and the binomial distribution -- Comparing two proportions -- Chi-squared tests for 2 x 2 and larger contingency tables -- Controlling for confounding: stratification -- Logistic regression: comparing two or more exposure groups -- Logistic regression: controlling for confounding and other extensions -- Matched studies -- Longitudinal studies, rates and the Poisson distribution -- Comparing rates -- Poisson regression -- Standardization -- Survival analysis: displaying and comparing survival patterns -- Regression analysis of survival data -- Likelihood -- Regression modelling -- Relaxing model assumptions -- Analysis of clustered data -- Systematic reviews and meta-analysis -- Bayesian statistics -- Linking analysis to study design: summary of methods -- Calculation of required sample size -- Measurement error: assessment and implications -- Measures of association and impact -- Strategies for analysis.

Neuromodulation is an emerging field that explores the use of electrical, chemical, and mechanical interventions to heal neurological deficits. Such neurostimulation has already shown great promise with disorders and diseases such as chronic pain, epilepsy, and Parkinson's disease. This is the first concise reference covering all of the basic principles of neuromodulation in a single affordable volume for neuro-residents, fellows, and basic clinical practitioners, edited by two prominent clinical experts in the field. This volume emphasizes essential observations from all of the important clinical phases involved in any neuromodulation: targeting, intraoperative assessment, programming, complications, and complication avoidance. There are commonalities to all neuromodulation procedures that must be brought to the forefront to form a cohesive presentation of neuromodulation, and such emphasis will give readers a more solid grounding in the fundamentals needed to embrace this field as a cohesive clinical entity.

Neurological assessment and examination -- Neurosurgical investigations -- Raised intracranial pressure and hydrocephalus -- Head injuries -- Traumatic intracranial haematomas -- Brain tumours -- Benign brain tumours -- Pituitary tumours -- Subarachnoid haemorrhage -- Stroke / Stephen M. Davis -- Developmental abnormalities -- Infections of the central nervous system -- Low back pain and leg pain -- Cervical disc disease and cervical spondylosis -- Spinal cord compression -- Spinal injuries -- Peripheral nerve entrapments, injuries and tumours -- Facial pain and hemifacial spasm -- Pain: neurosurgical management -- Movement disorders: neurosurgical aspects -- Epilepsy and its neurosurgical aspects / Christine Kilpatrick.

Basic nuclear medicine physics -- Interaction of radiation with matter -- Formation of radionuclides -- Nonscintillation detectors -- Nonimaging scintillation detectors -- Imaging instrumentation -- Single-photon emission computed tomography (SPECT) -- Positron emission tomography (PET) -- Combined PET/CT imaging -- Quality control -- Radiation biology -- Radiation dosimetry -- Radiation safety -- Management of nuclear event casualties.

Introduction -- History and clinical examination -- Orthopaedic anatomy -- Basic science in orthopaedics -- Investigations -- Methods of treatment -- The principles of managing trauma -- Immediate care and major incidents -- Methods of managing trauma -- Injuries to the face, head and spine -- Injuries to the trunk -- Injuries to the upper limb -- Hand injuries -- Injuries to the lower limb -- Sports injuries -- Osteoarthritis -- Rheumatoid arthritis and other arthropathies -- Bone and joint infections -- Metabolic disease, dysplasias, osteochondritis, and neurological disorders -- Granulomatous disorders and tumours -- Deformities in children -- Disorders of the shoulder and elbow -- Disorders of the wrist and hand -- Disorders of the hip and knee -- Disorders of the ankle and foot -- Disorders of the spine.

Anatomy of the ear / K. J. Lee -- Audiology / Kathleen C. M. Campbell, James E. Peck, and K. J. Lee -- Electrical response audiometry / Derald E. Brackmann, Manuel Don, and Weldon Selters -- The vestibular system / Charles C. Della Santina, Lloyd B. Minor, and John P. Carey -- Congenital hearing loss / K. J. Lee and Seilesh C. Babu -- Cochlear implants / Richard T. Miyamoto -- Skull base surgery / Paul J. Donald and Hilary A. Brodie -- Facial nerve paralysis / Elizabeth H. Toh and K. J. Lee -- Syndromes and eponyms / K. J. Lee and Mark Lee -- Embryology of clefts and pouches / K. J. Lee and Jay Farrior -- Cleft lip and palate / Eric J. Moore and Craig W. Senders -- Infections of the ear / Sarah S. Connell and Thomas J. Balkany -- Noninfectious disorders of the ear / Jay Farrior and K. J. Lee -- The nose and paranasal sinuses / Martin J. Citardi and Pete S. Batra -- The paranasal sinuses: embryology, anatomy, endoscopic diagnosis, and treatment / David W. Kennedy and Bradford A. Woodworth -- Obstructive sleep apnea / Jean M. Bruch and Nicolas Y. Busaba -- Immunology and allergy / John Houck -- Salivary gland diseases / Robert L. Witt -- The oral cavity, pharynx, and esophagus / David E. Eibling -- The larynx / Gayle E. Woodson and Ninef E. Zaya -- Neck spaces and fascial planes / Nilesh R. Vasan -- Thyroid and parathyroid glands / Ralph P. Tufano, Chad A Glazer, and Gregory W. Randolph -- Cysts and tumors of the jaws / John P. Kelly -- Carotid body tumors and vascular anomalies / Nilesh R. Vasan and Greg A. Krempl -- TNM classification in otolaryngology----head and neck surgery / Thomas G. Takoudes -- Malignant melanoma / Greg Krempl -- Cancer of the larynx, paranasal sinuses, and temporal bone / Nilesh R. Vasan -- Carcinoma of the oral cavity, pharynx, and esophagus / James P. Malone and K. Thomas Robbins -- Reconstructive head and neck surgery / Mark Delacure -- Facial plastic surgery / Tessa Hadlock and Mack L. Cheney -- Pediatric otolaryngology / Kathleen Sie -- Anesthesia for head and neck surgery / K. J. Lee -- Surgical hemostasis and clotting mechanisms / John E. Godwin and Raghu Kolluri -- Chemotherapy of head and neck cancer / Harold Tara and Bruce Lundberg -- Related neurology and neurosurgery / Isaac Goodrich, James C. McVeety, and K. J. Lee -- Related ophthalmology / K. J. Lee -- The chest / K. J. Lee -- Fluid, electrolytes, and nutrition / K. Chris McMains and Frank R. Miller -- Antimicrobial therapy in otolaryngology----head and neck surgery / David N. F. Fairbanks -- Pharmacology and therapeutics / Mark D'Agostino, K. J. Lee -- Highlights and pearls / Ryan B. Scannell and K. J. Lee.

Traumatic brain injury / Ramnik Singh and Michael W. O'Dell -- Stroke / Brenda S. Mallory -- Spinal cord injury / Monifa Brooks and Steven Kirshblum -- Prosthetics and orthotics / Heikki Uustal -- Cardiac rehabilitation / Mathew N. Bartels -- Pulmonary rehabilitation / Mathew N. Bartels -- Pediatric rehabilitation / Jilda N. Vargus-Adams -- Neuromuscular rehabilitation / Nancy E. Strauss, Shikha Sethi, and Stanley J. Myers -- Cancer rehabilitation / Michael D. Stubblefield and Christian M. Custodio -- Orthopedic rehabilitation / C. David Lin -- Spine and musculoskeletal medicine / Grant Cooper, Yusuf Tatli, and Gregory E. Lutz -- Electrodiagnostic medicine / Joseph Feinberg ... [et al.].

Seventh report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment Of High Blood Pressure / Benjamin J. Epstein -- Hyperlipidemia / Andrew Cohen and Neil S. Skolnik -- Management of newly diagnosed atrial fibrillation: a clinical practice guideline from the American Academy of Family Physicians and the American College of Physicians / Jaya Udayasankar and Doron Schneider -- Antithrombotic therapy for venous thromboembolic disease / George P.N. Samraj -- Antithrombotic therapy for atrial fibrillation, valvular heart disease, management of elevated INRs and perioperative management / Ann Peff and Doron Schneider -- Prevention of bacterial endocarditis / Margot Boigon and Doron Schneider -- Clinical guidelines for the diagnosis and treatment of asthma / Michael Gagnon and Neil S. Skolnik -- Community acquired pneumonia and health-care associated pneumonia clinical guidelines / John Russell -- Diagnosis and management of otitis media: joint guidelines from the American Academy of Pediatrics and American Academy of Family Physicians / Richard Neill --Appropriate antibiotic use for treatment of nonspecific upper respiratory infections, rhinosinusitis, and acute bronchitis in adults / Tina H. Degnan and Neil S. Skolnik -- Group A streptococcal pharyngitis: the Infectious Disease Society of America / Mario Napoletano -- Prevention of perinatal group B streptococcal disease / Ross Albert, Neil S. Skolnik, and Richard Neill -- Adult immunizations / Brett Fissell and Neil S. Skolnik -- Rabies prevention / Doron Schneider -- Practice guidelines for the management of infectious diarrhea / Pam Fenstemacher -- Tuberculosis testing and treatment of latent infection / Pam Fenstemacher -- Sexually transmitted diseases treatment guidelines, 2006 / Neil S. Skolnik -- Updated US public health service guidelines for the management of occupational exposure to HBV, HCV, and HIV and recommendations for postexposure prophylaxis / David Gary Smith -- Screening for osteoporosis in postmenopausal women / Richard Neill --Managing abnormal cervical cytology and cervical intraepithelial neoplasia: 2001 consensus guidelines / Amy Clouse -- Dementia / William McCarberg -- Diagnosis and treatment of migraine headaches / Richard Neill -- Concussion guidelines in athletes / David Webner -- Restless legs syndrome / Matthew Clark -- Depression: pharmacological treatment / John E. Sutherland -- Diagnosis, evaluation, and treatment of the school-aged child with attention deficit hyperactive disorder / Richard Neill -- Practice guidelines for the treatment of patients with delirium / Mary Hofmann and Doron Schneider -- Panic disorder / Diane Dietzen and Doron Schneider.

Knee injuries / Melanie A. Hopper and Andrew J. Grainger -- Hip, pelvis, and groin injuries / Philip Robinson -- Ankle and foot injuries / Ne Siang Chew ... [et al.] -- Osseous stress injury in athletes / Melanie A. Hopper and Philip Robinson -- Shoulder injuries / Andrew J. Grainger and Philip F.J. Tirman -- Elbow injuries / Kenneth S. Lee, Michael J. Tuite, and Humberto G. Rosas -- Hand and wrist injuries / Philip J. O'Connor -- Postoperative imaging in sports medicine / Ali Naraghi and Lawrence M. White -- Muscle injury and complications / Abhijit Datir and David A. Connell -- Sports-related disorders of the spine and sacrum / Rob Campbell and Andrew Dunn -- Ultrasound-guided sports intervention / Philip J. O'Connor.

This text presents a detailed introduction to SQLAlchemy, the code library for Python users that makes it easier to access popular databases such as Oracle and MySQL. It demonstrates how to use the library to create simple database applications, and walks readers through simple queries.

Getting started in laparascopy -- Laparoscopic instrumentation -- Laparoscopic access -- Laparoscopic and robotic pelvic lymphadenectomy -- Laparoscopic renal cyst decorticadtion -- Laparoscopic simple nephrectomy -- Laparoscopic readical nephrectomy: transperitoneal approach -- Laparoscopic radical nephrectomy -- Laparoscopic partial nephrectomy -- Laparoscopic nephroureterectomy -- Laparoscopic live donor nephrectomy -- Laparoscopic and robotic pyeloplasty -- Laparoscopic adrenalectomy -- Laparoscopic retroperitoneal lymph node dissection for nonseminomatous germ cell tumors -- Laparoscopic cystectomy and urinary diversion -- Laparoscopic radical cystectomy and urinary diversion with handport assistance -- Laparoscopic and robotic-assisted laparoscopic radical prostatectomy -- Complications of laparoscopic urologic surgery -- Laparoscopic renal ablation.

Part 1. General Pathology -- Cytopathology / Fadi W. Abdul-Karim, Jennifer Brainard and Claire W. Michael -- Immunohistochemical Diagnosis in Surgical Pathology / Nancy Klipfel, Raul Simental-Pizarro and Clive R. Taylor -- Tumors of Unknown Primary / Nancy Klipfel, Raul Simental-Pizarro and Clive R. Taylor -- Diagnostic Electron Microscopy / Jean L. Olson -- Transplantation Pathology / Oscar W. Cummings -- Microbiology for the Surgical Pathologist / Deborah E. Blue and Stephen D. Allen -- Forensic Pathology / Frank P. Miller and Jeffrey J. Barnard -- Autopsy / Dean Hawley -- Biomedical Informatics for Anatomic Pathology / Waqas Amin, Uma Chandran, Anil V. Parwani and Michael J. Becich -- Quality Assurance and Regulations for Anatomic Pathology / Maxwell L. Smith and Stephen S. Raab -- Molecular Diagnostic Pathology / James Huang and Richard D. Press -- Molecular Pathology of Solid Tumors / Franklin R. Moore and Richard D. Press -- Human Genetic Disorders / Teresa M. Kruisselbrink, Noralane M. Lindor, Elyse B. Mitchell, Brittany C. Thomas and Cassandra K. Runke, et al. -- Part 2. Organ Systems -- Neuropathology / Eyas M. Hattab, Matthew C. Hagen, Bernd W. Scheithauer and Arie Perry -- Lymph Node / Ellen D. McPhail and Paul J. Kurtin -- Spleen / Dennis P. O'Malley and Attilio Orazi -- Bone Marrow / Dennis P. O'Malley -- Neoplasms of the Skin and Immunodermatology / Daniel P. Vandersteen, Melanie Triffet-Treviño and Chris H. Jokinen -- Nonneoplastic Skin Diseases / Steven D. Billings and Antoinette F. Hood -- Endocrine Pathology / Lori A. Erickson -- Bone and Joints / Jasvir S. Khurana and Guldeep Uppal -- Soft Tissue Tumors / Leona A. Doyle and Alessandra F. Nascimento -- Tumor of the Salivary Glands / Diana M. Bell and Adel K. El-Naggar -- Head and Neck / John D. Henley and Don-John Summerlin -- Eye and Ocular Adnexae / Jose M. Bonnin -- Mediastinum and Thymus / Chung-Che (Jeff) Chang, Munir Shahjahan and Joseph F. Tomashefski -- Cardiovascular Pathology / Eric A. Pfeifer -- Lung and Pleura / Carol F. Farver and Andrea V. Arrossi -- Breast / Mohiedean Ghofrani and Fattaneh A. Tavassoli -- Vulva and Vagina / Sharon X. Liang and Wenxin Zheng -- Uterus and Fallopian Tube / Maritza Martel and Fattaneh A. Tavassoli -- Ovary and Peritoneum / Robert E. Emerson -- Placenta and Gestational Trophoblastic Disease / Raymond W. Redline -- Nonneoplastic Renal Diseases / Geoffrey A. Talmon and Donna J. Lager -- Tumors of the Kidney / Gregory T. MacLennan and Liang Cheng -- Urinary Bladder / Liang Cheng, Antonio Lopez-Beltran and David G. Bostwick -- Renal Pelvis, Ureter, and Urethra / Antonio Lopez-Beltran, Sean R. Williamson and Liang Cheng -- Prostate / David G. Bostwick and Liang Cheng -- Testis and Testicular Adnexa / Kenneth A. Iczkowski and Thomas M. Ulbright -- The Penis / Alcides Chaux, Gustavo Ayala and Antonio L. Cubilla -- Esophagus and Stomach / Thomas P. Plesec and John R. Goldblum -- Small Intestine, Appendix, Colorectum, and Anus / Stephen C. Lawhorn and Shuan C. Li -- Pancreas / Olca Basturk and N. Volkan Adsay -- Nonneoplastic Hepatobiliary Disease / Romil Saxena -- Neoplasms of the Liver and Biliary System / Romil Saxena.

Postmorten toxicological redistribution -- Examination of fractures at autopsy -- The relationship of body weight and sudden death -- Fatal sexual abuse in childhood -- Elder abuse and gerontocide -- Air crash investigation for histopathologists -- Bioterrorism -- The chronological dating of injury.

Volume 1. Foundations of Chinese Medicine -- Volume 2. Clinical Fundamentals in Chinese Medicine -- Volume 3. Essentials of the Clinical Specialties in Chinese Medicine.

Basic components: structure and function -- Infection -- Immunodeficiency -- Anaphylaxis and allergy -- Autoimmunity -- Lymphoproliferative disorders -- Immune manipulation -- Transplantation -- Kidney diseases -- Joints and muscles -- Skin diseases -- Eye diseases -- Chest diseases -- Gastrointestinal and liver diseases -- Endocrinology and diabetes -- Haematological diseases -- Neuroimmunology -- Pregnancy -- Techniques in clinical immunology.

"Clinical Mycology" offers a comprehensive review of this discipline. Organized by types of fungi, this volume covers microbiologic, epidemiologic and demographic aspects of fungal infections as well as diagnostic, clinical, therapeutic, and preventive approaches. Special patient populations are also detailed.

I. pt. I. Clinical Research: Definitions, "Anatomy and Physiology," and the Quest for "Universal Truth" / Stephen P. Glasser, p. 3-11 -- Introduction to Clinical Research and Study Designs / Stephen P. Glasser, p. 13-27 -- Clinical Trials / Stephen P. Glasser, p. 29-62 -- Alternative Interventional Study Designs / Stephen P. Glasser, p. 63-71 -- Postmarketing Research / Stephen P. Glasser, Elizabeth Delzell and Maribel Salas, p. 73-91 -- The United States Federal Drug Administration (FDA) and Clinical Research / Stephen P. Glasser, Carol M. Ashton and Nelda P. Wray, p. 73-110 -- The Placebo and Nocebo Effect / Stephen P. Glasser and William Frishman, p. 111-140 -- Recruitment and Retention / Stephen P. Glasser, p. 141-149 -- Data Safety and Monitoring Boards (DSMBs) / Stephen P. Glasser and O. Dale Williams, p. 151-158 -- Meta-Analysis / Stephen P. Glasser and Sue Duval, p. 159-177 -- II. pt. II. -- Research Methods for Genetic Studies / Sadeep Shrestha and Donna K. Arnett, p. 181-199 -- Research Methods for Pharmacoepidemiology Studies / Maribel Salas and Bruno Stricker, p. 201-216 -- Implementation Research: Beyond the Traditional Randomized Controlled Trial / Amanda H. Salanitro, Carlos A. Estrada and Jeroan J. Allison, p. 217-244 -- Research Methodology for Studies of Diagnostic Tests / Stephen P. Glasser, p. 245-257 -- III. pt. III. Statistical Power and Sample Size: Some Fundamentals for Clinician Researchers / J. Michael Oakes, p. 261-278 -- Association, Cause, and Correlation / Stephen P. Glasser and Gary Cutter, p. 279-294 -- Bias, Confounding, and Effect Modification / Stephen P. Glasser , p. 295-302 -- It's All About Uncertainty / Stephen P. Glasser and George Howard, p. 303-316 -- Grant Writing / Donna K. Arnett and Stephen P. Glasser, p. 317-325 -- IV. pt. IV. The Media and Clinical Research / Stephen P. Glasser, p. 329-333 -- Mentoring and Advising / Stephen P. Glasser and Edward W. Hook, p. 335-340 -- Presentation Skills: How to Present Research Results / Stephen P. Glasser, p. 341-349.

An overview of creatine metabolism / Jeff S. Volek, Kevin D. Ballard, and Cassandra E. Forsythe -- Creatine supplementation in strength-power sports / Darryn S. Willoughby -- Creatine supplementation in endurance sports / Joel P. Cramer -- Creatine supplementation and woman athletes / Joan Eckerson -- Creatine consumption and health / Jacques R. Poortmans and Marc Francaux -- Clinical application / Joseph Weir -- Creatine overview : facts, fallacies, and future / Mike Greenwood.

The Normal Breast -- Specimen Processing -- Fibrocystic Change and Duct Ectasia -- Adenosis -- Intraductal Proliferative Lesions -- Intraductal Papillary Neoplasms -- Lobular Intraepithelial Neoplasia (LIN) -- Infiltrating Ductal Carcinoma (NOS Type) -- Invasive Lobular Carcinoma (ILC) -- Special Types of Breast Carcinomas -- Biphasic Tumors -- Disease of the Nipple -- Male Breast Lesions -- Mesenchymal Lesions/Tumors -- Myoepithelial Lesions/Neoplasms -- Miscellaneous Lesions -- Cytopathology of Benign and Malignant Lesions (Selected Topics) -- Immunohistochemistry (Selected Topics).

"During the last two decades, new developments in functional MRI (magnetic resonance imaging) have made it possible to detect changes in the brain over time, as opposed to the "snapshot" produced by conventional MRI. Essentials of Functional MRI breaks down the technical challenges for physicians, researchers, and technologists who use functional MRI but may not be experts in the necessary math and physics. The author describes the theory and practical details of functional MRI (fMRI) methodology, including how to acquire and analyze images, and a wide range of examples demonstrate how fMRI has been used thus far. The author provides the essential information to study, understand, use, and teach the practical aspects of fMRI for those people who are most likely to extend its use into clinical practice"--Provided by publisher.

The foundations of genomic and personalized medicine -- Section 1. Basics -- Organization, variation and expression of the human genome -- DNA sequencing for the detection of human genome variation -- Genome-wide association studies and genotyping technologies -- Copy number variation and human health -- DNA methylation analysis: providing new insight into human disease -- DNA microarrays in biological discovery and patient care -- Proteomics: the deciphering of the functional genome -- Comprehensive metabolic analysis for understanding of disease -- Section 2. Informatics -- Bioinformatic and computational analysis for genomic medicine -- Systems biology and systems medicine -- Electronic medical records in genomic medicine practice and research -- Online health information retrieval by consumers -- Section 3. Translational -- Translational genomics: from discovery to clinical practice -- Pharmacogenetics and pharmacogenomics -- Clinical implementation of translational genomics -- The role of genomics in enabling prospective health care -- Genome policy considerations for genomic medicine -- Federal regulation of genomic medicine -- Economic issues and genomic medicine -- Public health genomics.Section 4. Clinical (cardiology) -- The genomics of hypertension -- Lipoprotein disorders -- Genomics of myocardial infarction -- Acute coronary syndromes -- Heart failure in the era of genomic medicine -- Genomic assessment of cardiac transplant rejection -- Genetics and genomics of hypertrophic cardiomyopathy -- Genetics and genomics of arrhythmias -- Genetics and genomics in the management of hemostasis and thrombosis -- Genomics of congenital heart disease -- Section 5. Clinical (oncology) -- Genomics in the management of lymphomas -- Genomics in leukemias -- Genomics in the diagnosis and management of lung cancer -- Genomics in the diagnosis and management of breast cancer -- Colorectal cancer -- Genomic evaluation and management of prostate cancer -- Genomic assessment of ovarian cancer -- Genomic evaluation of pancreatic neoplasms -- Genomic evaluation of head and neck cancer -- Genomic evaluation of brain tumors and gliomas -- Targeted therapies for cancer.Section 6. Clinical (inflammatory disease) -- Genomics in the evaluation and management of rheumatoid arthritis -- Genomic evaluation of multiple sclerosis -- Genomic assessment of inflammatory bowel disease -- Asthma genomics -- Genomics in the evaluation and management of chronic obstructive pulmonary disease -- Genetics and genomics of interstitial lung disease -- Peptic ulcer disease -- Section 7. Clinical (metabolic disease) -- Genomics in pathogenesis of cirrhosis -- Genomic medicine and obesity -- Diabetes -- Section 8. Clinical (neurological disease) -- Genetics and genomics of dementia -- Genetics and genomics of Parkinson's disease -- Genomic considerations in ophthalmology -- Genomics in the diagnosis and management of depression -- Section 9. Clinical (infectious disease) -- Genomic approaches to the host response to pathogens -- Host genomics and bacterial infections -- Genomics in the evaluation and management of sepsis -- Genomics and the management of hepatitis.

Why learn methods in infectious disease epidemiology? -- Why study methods? -- Descriptive infectious disease epidemiology -- Outbreak investigations -- Rates and measures -- Laying the foundation: how to conduct a study -- Experimental designs as a foundation for observational studies -- Cohort studies -- Case-control and cross-sectional studies -- Interpretation of epidemiologic data -- Threats to internal and external validity of concern in the study of infectious disease epidemiology -- Surveillance of infectious diseases -- Program evaluation in the infectious disease setting.

Radioactivity, radionuclides, and radiopharmaceuticals -- Instrumentation and quality control -- Central nervous system -- Thyroid, parathyroid, and salivary glands -- Cardiovascular system -- Respiratory system -- Gastrointestinal tract -- Skeletal system -- Genitourinary system and adrenal glands -- Non-PET neoplasm imaging and radioimmunotherapy -- ¹⁸F-FDG PET/CT neoplasm imaging -- Inflammation and infection imaging -- Authorized user and radioisotope safety issues -- Self-evaluation. Unknown case sets -- Answers to unknown case sets -- Appendix A: Characteristics of radionuclides for imaging and therapy -- Appendix B-1: Radioactivity conversion table for International System (SI) Units (Becquerels to Curies) -- Appendix B-2: Radioactivity conversion table for International System (SI) Units (Curies to Becquerels) -- Appendix C-1: Technetium-99m decay and generation tables -- Appendix C-2: Other radionuclide decay tables -- Appendix D: Injection techniques and pediatric dosages -- Appendix E-1: Sample techniques for nuclear imaging -- Appendix E-2: Abnormal radio pharmaceutical distribution as a result of medications and other extrinsic factors -- Appendix F: Nonradioactive pharmaceuticals in nuclear medicine -- Appendix G: Pregnancy and breastfeeding -- Appendix H-1: General considerations for hospitalized patients receiving radionuclide therapy -- Appendix H-2: Special considerations and requirements for iodine-131 therapy -- Appendix I: Emergency procedures for spills of radioactive materials.

Ch. 1Ocular anatomy, physiology, and embryology --Ch. 2Basic optics --Ch. 3Ocular pharmacology --Ch. 4The eye exam --Ch. 5Neuro-ophthalmology --Ch. 6Pediatric ophthalmology and strabismus --Ch. 7Orbit --Ch. 8Lids and adnexa --Ch. 9Conjunctiva --Ch. 10Sclera --Ch. 11Cornea --Ch. 12Anterior chamber --Ch. 13Glaucoma --Ch. 14Iris --Ch. 15Lens --Ch. 16Vitreous --Ch. 17Retina --App.Differential diagnosis of common ocular symptoms.

Section I. Basic Considerations -- Section II. Clinical Evaluation and Diagnostic Examinations -- Section III. Pharmacology and Pharmacologic Modalities -- Section IV. Therapeutic Interventions -- Section V. Perioperative Pain Management -- Section VI. Chronic Pain Syndromes -- Section VII. Interventional Techniques for Pain Management -- Section VIII. Cancer Pain -- Section IX. Nerve Blockade.

Introduction -- Fistula First, K/DOQI and Documentation -- The Dialysis Outcomes and Practice Pattern Study (DOPPS): Lessons for Interventionalists -- Controversies in Vascular Access Monitoring and Surveillance -- Clinical Relevance of Vascular Access Monitoring and Surveillance -- Molecular Mechanisms of Hemodialysis Graft Failure -- The Vascular Access Coordinator -- The Procedure Room, Equipment and Radiation Safety -- Patient Considerations and Preparation -- Patient Monitoring, Sedation and Post-Procedure Care -- Sterile Technique -- Contrast Agents -- Dialysis Catheters -- Dialysis Grafts Versus Fistulas -- Commonality of Interventions in AV Accesses -- Interventions in Dialysis Grafts -- Interventions in Dialysis Fistulas -- The Immature or Failure to Mature Fistula -- Cephalic Arch Stenosis -- Central Venous Interventions -- Hemodialysis Access Interventions: An Asian Perspective -- Pediatric Hemodialysis Interventions -- Puncture Site Management -- No Remaining Venous Access -- Radiologic Peritoneal Dialysis Catheter Insertion and Troubleshooting -- Complications and Possible Solutions -- On-Label, Off-Label, Misconceptions and Devices that Do not Work -- Publications of Hemodialysis Interventions: What Is Relevant? -- Interesting Cases.

Cervical spondylotic myelopathy -- Cervical facet arthropathy -- Cervical degenerative disease -- Cervical radiculopathy -- Cervical sprain or strain -- Cervical stenosis -- Cervicogenic vertigo -- Trapezius strain -- Acromioclavicular injuries -- Adhesive capsulitis -- Biceps tendinitis -- Biceps tendon rupture -- Glenohumeral instability -- Rotator cuff tendinitis -- Rotator cuff tear -- Scapular winging -- Shoulder arthritis -- Elbow arthritis -- Epicondylitis -- Median neuropathy -- Olecranon bursitis -- Radial neuropathy --Ulnar neuropathy (elbow) -- de quervain tenosynovits -- Dupuytren contracture -- Extensor tendon injuries -- Flexor tendon injuries -- Hand and wrist ganglia -- Hand osteoarthritis -- Kienböck disease -- Median neuropathy (carpal tunnel syndrome) -- Trigger finger -- Ulnar collateral ligament sprain -- Ulnar neuropathy (wrist) -- Wrist osteoarthritis -- Wrist rheumatoid arthritis -- Thoracic compression fracture -- Thoracic radiculopathy -- Thoracic sprain or strain -- Lumbar degenerative disease -- Lumbar facet arthropathy -- Lumbar radiculopathy -- Low back strain or sprain -- Lumbar spondylolysis and spondylolisthesis -- Lumbar spinal stenosis -- Sacroiliac joint dysfunction -- Hip osteoarthritis -- Femoral neuropathy -- Lateral femoral cutaneous neuropathy -- Piriformis syndrome -- Quadriceps contusion -- Total hip replacement -- Trochanteric bursitis -- Anterior cruciate ligament tear -- Baker's cyst -- Collateral ligament sprain -- Compartment syndrome -- Hamstring strain -- Iliotibial band syndrome -- Knee osteoarthritis -- Knee bursitis -- Meniscal injuries -- Jumper's knee -- Patellofemoral syndrome -- Peroneal neuropathy -- Posterior cruciate ligament sprain -- Quadriceps tendinitis -- Shin splints -- Stress fractures -- Total knee replacement -- Achilles tendinitis -- Ankle arthritis -- Foot and ankle bursitis -- Ankle sprain -- Bunion and bunionette --Chronic ankle instability -- Claw toe -- Corns -- Foot and ankle ganglia -- Hallux rigidus -- Hammer toe -- Mallet toe -- Metatarsalgia -- Morton neuroma -- Plantar fasciitis -- Posterior tibial tendon dysfunction -- Tibial neuropathy (tarsal tunnel syndrome) -- Occipital neuralgia -- Trigeminal neuralgia -- Thoracic outlet syndrome -- Chronic pain syndrome -- Complex regional pain syndrome -- Headaches -- Fibromyalgia -- Myofascial pain syndrome -- Repetitive strain injuries -- Costosternal syndromes -- Intercostal neuralgia -- Tietze syndrome -- Postherpetic neuralgia -- Arachnoiditis -- Coccydynia -- Phantom limb pain -- Cervical dystonia -- Post-thoracotomy pain syndrome -- Post-mastectomy pain syndrome -- Upper limb amputations -- Lower limb amputations -- Ankylosing spondylitis -- Burns -- Cardiac rehabilitation -- Cancer -- Cerebral palsy -- Chronic fatigue syndrome -- Chronic kidney disease -- Joint contractures -- Deep venous thrombosis -- Dementia -- Management of the patient with a foot at risk: peripheral arterial disease and diabetes -- Dysphagia -- Enteropathic arthritides -- Heterotopic ossification -- Lymphedema -- Motor neuron disease -- Movement disorders -- Multiple sclerosis -- Myopathies -- Neurogenic bladder -- Osteoarthritis -- Osteoporosis -- Parkinson disease -- Peripheral neuropathies -- Plexopathy-brachial -- Plexopathy-lumbosaral -- Polytrauma rehabilitation -- Post-poliomyelitis syndrome -- Post-concussion disorders -- Psoriatic arthritis -- Pressure ulcers -- Pulmonary rehabilitation -- Rheumatoid arthritis -- Scoliosis and kyphosis -- Spasticity -- Speech and language disorders -- Spinal cord injury (cervical) -- Spinal cord injury (thoracic) -- Spinal cord injury (lumbosacral) -- Stroke -- Stroke in young adults -- Systemic lupus erythematosus -- Transverse myelitis -- Traumatic brain injury.

Basic chemistry -- General prinicples of gas physics -- Microbiology, sterilization, and infection control -- Anatomy of the respiratory system -- Mechanics of ventilation -- Neurologic control of ventilation -- Oxygen and carbon dioxide transport -- Intrapulmonary shunting and deadspace -- Antomy of the cardiovascular system -- Physiology of the cardiovascular system -- Cardiac electrophysiology and ECG interpretation -- Hemodynamic monitoring -- Renal anatomy and physiology -- Fluid and electrolyte balance -- Acid-base balance and blood gas interpretation -- Anatomy and physiology of the nervous system -- Pharmacology -- Clinical assessment of the cardiopulmonary system -- Pulmonary function testing -- Obstructive pulmonary disease and general management principles -- Obstructive pulmonary disease and ventilatory management -- Restrictive lung diseases: general and ventilatory management -- ARDS, SARS, and sepsis -- Nutrition -- Intrauterine development and comparative respiratory anatomy -- Assessment and management of the newborn -- Respiratory disorders of the newborn -- Mechanical ventilation of the newborn -- Respiratory disorders of the pediatric patient -- Assisted ventilation for pediatric patients -- Pulmonary rehabilitation -- Home respiratory care and mechanical ventilation -- Gas therapy -- Oxygen, helium, and nitric oxide therapy -- Aerosol and humidity therapy -- Airway clearence techniques -- Analyzers -- Airway care -- Modes of mechanical ventilation -- Positive end-expiratory pressure -- Initiation, maintenance, and weaning from mechanical ventilation -- High frequency ventilation -- Noninvasive positive pressure ventilation -- Tracheal gas insufflation -- Prone positioning -- Liquid ventilation.

Introduction to stem cells -- Basic biology/mechanisms -- Tissue and organ development -- Methods -- Applications -- Regulation and ethics.

Anesthesiology / Susan L. Polk ... [et al.] -- Pediatric surgery: surgical diseases of children / Philip J. Wolfson ... [et al.] -- Plastic surgery: diseases of the skin and soft tissue, face, and hand / Garrett A. Wirth and Gregory R.D. Evans -- Cardiothoracic surgery: diseases of the heart, great vessels, and thoracic cavity / Alan Spotnitz, Marshall L. Jacobs, and Manisha R. Shende -- Otolaryngology: diseases of the head and neck / Gerald Berke ... [et al.] -- Orthopedic surgery: diseases of the musculoskeletal system / John J. Murnaghan -- Urology: diseases of the genitourinary system / Joel Gelman, Barry P. Duel, and Isaac Yi Kim -- Neurosurgery: diseases of the nervous system / Mark E. Linskey -- Ophthalmology: diseases of the eye / Alan S. Crandall Jr. ... [et al.].

Normality, disease and enhancement / Theodore M. Benditt -- Holistic theories of health as applicable to non-human living beings / Lennart Nordenfelt -- Disease and the concept of supervenience / Robert D'Amico -- Decision and discovery in defining disease / Peter H. Schwartz -- Race and scientific reduction / Mark Risjord -- Towards an adequate account of genetic disease / Kelly C. Smith -- Why disease persists / Robert L. Perlman -- Creating mental illness in non-disordered community populations / Allan V. Horwitz -- Gender identity disorder / Jennifer McKitrick -- Clinical trials as nomological machines / Robyn Bluhm -- The social epistemology of NIH consensus conferences / Miriam Solomon -- Maternal agency and the immunological paradox of pregnancy / Moira Howes -- Violence and public health / Jonathan Kaplan -- Taking equipoise seriously / Fred Gifford.