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    Introduction and scope of study -- Osteochondroma (osteocartilaginous exostosis) -- Chondroma -- Benign chondroblastoma -- Chondromyxoid fibroma -- Chondrosarcoma (primary, secondary, dedifferentiated, and clear cell) -- Mesenchymal chondrosarcoma -- Osteoma -- Osteoid osteoma -- Osteoblastoma (giant osteoid osteoma) -- Osteosarcoma -- Parosteal osteosarcoma (juxtacortical osteosarcoma) -- Fibrosarcoma and desmoplastic fibroma -- Benign fibrous histiocytoma -- Malignant fibrous histiocytoma -- Myeloma -- Malignant lymphoma of bone -- Ewing tumor -- Giant cell tumor (osteoclastoma) -- Malignancy in giant cell tumor of bone -- Chordoma -- Benign vascular tumors -- Angiosarcoma and hemangiopericytoma -- Adamantinoma of long bones -- Miscellaneous unusual tumors of bone -- Conditions that commonly simulate primary neoplasms of bone -- Odontogenic and related tumors.
  • v. II Springer
    Also available: Print – v. 1-2., 2008
    v. 1. Nonneoplastic lung disease -- v. 2. Neoplastic lung disease.
  • Also available: Print – 2008
    Prenatal care / Vern L. Katz -- Normal labor, delivery, newborn care, and puerperium / Kirsten J. Lund and James McManaman -- Obstetric analgesia and anesthesia / Joy L. Hawkins -- Early pregnancy loss / T. Flint Porter, D. Ware Branch, and James R. Scott -- Ectopic pregnancy / Beata E. Seeber and Kurt T. Barnhart -- Genetics in obstetrics and gynecology / Kenneth Ward -- Prenatal diagnosis / Lorraine Dugoff -- Drugs in pregnancy / Jerome Yankowitz -- Ultrasound in obstetrics / Santosh Pandipati and John C. Hobbins -- Assessment of fetal well-being / Catherine Y. Spong -- Preterm labor and post-term delivery / J. Chris Carey and Ronald S. Gibbs -- Premature rupture of the membranes / Ronald S. Gibbs -- Intrauterine growth restriction / Bronwen F. Kahn, John C. Hobbins, and Henry L. Galan -- Multiple gestation / Roger B. Newman and Charles Rittenberg -- Diabetes mellitus and pregnancy / E. Albert Reece and Carol J. Homko -- Hypertensive disorders of pregnancy / Mounira Habli and Baha M. Sibai -- Medical and surgical complications of pregnancy / Deborah Krakow -- Immunologic disorders in pregnancy / D. Ware Branch, Robert M. Silver, and Kjersti Aagaard-Tillery -- Obstetric and perinatal infections / Jill K. Davies and Ronald S. Gibbs -- Human immunodeficiency virus / Howard Minkoff -- Placenta previa and abruption / Helen H. Kay -- Breech, other malpresentations, and umbilical cord complications / Timothy E. Klatt and Dwight P. Cruikshank -- Stillbirth and intrauterine fetal demise / Robert M. Silver -- Complications of labor / Donald J. Dudley -- Complications of delivery / Larry C. Gilstrap and Edward R. Yeomans -- Operative vaginal delivery / James A. Bofill and James N. Martin, Jr. -- Cesarean delivery / James R. Scott and T. Flint Porter -- Psychologic disorders of pregnancy and the postpartum period / Michael W. O'Hara and Lisa S. Segre -- Office gynecology and surgical procedures / Marian D. Damewood, William R. Keye, Jr., and Charles C. Coddington III -- Gynecologic ultrasound / Mika Thomas and Bradley J. Van Voorhis -- Pediatric and adolescent gynecology / Ann J. Davis -- Contraception / Lisa Memmel and Melissa Gilliam -- Induced abortion / Sabrina Holmquist and Melissa Gilliam -- Pelvic and sexually transmitted infections / David A. Eschenbach -- Benign vulvovaginal disorders / Lori A. Boardman and Colleen M. Kennedy -- Amenorrhea / David P. Cohen -- Abnormal uterine bleeding / Steven R. Goldstein -- Premenstrual syndrome / Robert L. Reid -- Androgen excess disorders / Richard S. Legro and Ricardo Azziz -- Infertility / Kristen P. Wright and Julia V. Johnson -- Endometriosis / Robert S. Schenken -- Menopause / Marcelle I. Cedars and Michele Evans -- Women's sexuality and sexual dysfunction / Rosemary Basson -- Chronic pelvic pain / Howard T. Sharp -- Perioperative evaluation / Jeff Peipert and Sarah Hammil -- Laparoscopic surgery / Joseph S. Sanfilippo and Lisa M. Roberts -- Hysteroscopic surgery / R. Stanford Williams -- Epidemiology, pathophysiology, and evaluation of pelvic organ support / John O. L. DeLancey -- Operative management of pelvic organ prolapse / Kris Strohbehn and Holly E. Richter -- Nonsurgical treatment of pelvic organ prolapse / Ingrid D. Nygaard -- Female urinary incontinence: epidemiology and evaluation / Peggy A. Norton --Operative management of urinary incontinence / Charles W. Nager and Amy R. Kane -- Nonsurgical management of urinary incontinence and overactive bladder / Baharak Amir and Alfred E. Bent -- Fecal incontinence and defecation disorders / Dee E. Fenner and Catherine Ann Matthews -- Leiomyomata / Arthur F. Haney -- Disorders of the breast / Mary L. Gemignani -- Vulvar and vaginal cancer / Natalie S. Gould and Joan L. Walker -- Cervical cancer / Robert L. Giuntoli II and Robert E. Bristow -- Human papillomavirus and the management of the abnormal pap test / Christine H. Holschneider -- Uterine cancer / David G. Mutch -- Ovarian and tubal cancers / Ilana Cass and Beth Y. Karlan -- Management of the adnexal mass / Susan A. Davidson -- Gestational trophoblastic neoplasms / Andrew John Li -- The special approach to solving the profession's liability crisis, improving patient safety, and preventing medical errors / Louis Weinstein and Jason K. Baxter -- Appendix: Evidence-based approach to obstetrics and gynecology / Ronald S. Gibbs.
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    Book I--On the origin of the species - Book II--Voyage of the Beagle - Book III--The descent of man - Book IV--The expression of the emotions in man and animals.
  • Classification of the Antibiotics -- Antibiotics Marketed in the EU -- Principles of Antibiotic Therapy -- The Most Common Errors in Antibiotic Therapy -- Important Infections and Their Microbiological Diagnosis -- Cooperation with Microbiologists -- Resistance of Major Clinical Pathogens -- The Most Frequent Pathogens- Choice of Antibiotics -- Antibiotics, Antimycotics: Spectrum- Dosage- Adverse Effects- Costs -- Antibiotic Therapy of the Principal Infections in Children and Adults -- Treatment of the Most Frequent Types of Bacterial Endocarditis -- Minimal Duration of Treatment for Bacterial Infections -- Failure of Antibiotic Therapy -- Fever of Unknown Origin: Differential Diagnosis -- Dosage of Antibiotics in Impaired Renal Function -- Antibiotic Therapy in Haemodialysis, Peritoneal Dialysis, and Continuous Haemofiltration -- Antibiotic Therapy During Pregnancy and Lactation -- Antibiotics in Liver Diseases -- Diffusion of Antibiotics in Cerebrospinal Fluid and in Cerebral Abscesses -- Local Antibiotics -- Prophylactic Antibiotic Therapy -- Physical Incompatibility of Antibiotics and Antimycotics in Infusion Solutions -- Useful Websites.
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  • Introduction -- Organization of a safety monitoring program for a confirmatory trial -- Meetings -- Clinical issues -- Statistical issues -- Bias and pitfalls -- Data monitoring committee decisions -- Emerging issues.
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  • RWJF and the Advisory Committee hosted a listening tour of five "Learning What Works" events in diverse cities across the country: Philadelphia; Phoenix; Des Moines, Iowa; San Francisco; and Charleston, South Carolina. A broad spectrum of individuals--from health care providers to researchers to community service providers to business leaders interested in using data to improve their health and the health of their communities--attended these five events. The forums generated key observations and examples, as well as many questions around using, exchanging, and protecting data and what individuals and communities want and need in order to improve health or foster connections between different sectors. These observations provided the basis for the Advisory Committee's findings and recommendations, which are detailed in this report.
  • SU Catalog (SearchWorks) Click LINK above for Print location/circulation status.
  • Part I. Machine Learning Tools and Techniques: -- 1. What's it all about? -- 2. Input: concepts, instances, and attributes -- 3. Output: knowledge representation -- 4. Algorithms: the basic methods -- 5. Credibility: evaluating what's been learned -- Part II. Advanced Data Mining: -- 6. Implementations: real machine learning schemes -- 7. Data transformation -- 8. Ensemble learning -- 9. Moving on: applications and beyond -- Part III. The Weka Data Mining Workbench: -- 10. Introduction to Weka -- 11. The explorer -- 12. The knowledge flow interface -- 13. The experimenter -- 14 The command-line interface -- 15. Embedded machine learning -- 16. Writing new learning schemes -- 17. Tutorial exercises for the Weka explorer.
  • Data mining and knowledge discovery handbook 2005
    books24x7, SUNet ID login required.
  • SU Catalog (SearchWorks) Click LINK above for Print location/circulation status.
  • "Data mining has rapidly emerged as an enabling, robust, and scalable technique to analyze data for novel patterns, trends, anomalies, structures, and features that can be employed for a variety of biomedical and clinical domains. Approaching the techniques and challenges of image mining from a multidisciplinary perspective, this book presents data mining techniques, methodologies, algorithms, and strategies to analyze biomedical signals and images. Written by experts, the text addresses data mining paradigms for the development of biomedical systems. It also includes special coverage of knowledge discovery in mammograms and emphasizes both the diagnostic and therapeutic fields of eye imaging"--Provided by publisher.
  • Instruments and methods in proteomics -- In-depth protein characterization by mass spectrometry -- Analysis of phosphoproteomics data -- The origin and early reception of sequence databases -- Laboratory data and sample management for proteomics -- PRIDE and "Database on demand" As valuable tools for computational proteomics -- Analysing proteomics identifications in the context of functional and structural protein annotation: Integrating annotation using PICR, DAS, and BioMart -- Tranche distributed repository and proteomecommons.Org -- Data standardization by the HUPO-PSI: How has the community benefitted? -- mzIdentML: An open community-built standard format for the results of proteomics spectrum identification algorithms -- Spectra, chromatograms, metadata: mzML-the standard data format for mass spectrometer output -- imzML: Imaging mass spectrometry markup language: A common data format for mass spectrometry imaging -- Tandem mass spectrometry spectral libraries and library searching -- Inter-lab proteomics: Data mining in collaborative projects on the basis of the HUPO brain proteome project's pilot studies -- Data management and data integration in the HUPO plasma proteome project -- Statistics in experimental design, preprocessing, and analysis of proteomics data -- The evolution of protein interaction networks -- Cytoscape: Software for visualization and analysis of biological networks -- Text mining for systems modeling -- Identification of alternatively spliced transcripts using a proteomic informatics approach -- Distributions of ion series in ETD and CID spectra: Making a comparison -- Evaluation of peak-picking algorithms for protein mass spectrometry -- OpenMS and TOPP: Open source software for LC-MS data analysis -- LC/MS data processing for label-free quantitative analysis -- Spectral properties of correlation matrices - towards enhanced spectral clustering -- Standards, databases, and modeling tools in systems biology -- Modeling of cellular processes: Methods, data, and requirements.
  • An approach to analyzing and modeling systems for real-time decisions / John C. Brocklebank ... [et al.] -- Ensemble strategies for neural network classifiers / Paul Mangiameli and David West -- Neural network classification with uneven misclassification costs and imbalanced group sizes / Jyhshyan Lan ... [et al.] -- Data cleansing with independent component analysis / Guangyin Zeng and Mark J. Embrechts -- A multiple criteria approach to creating good teams over time / Ronald K. Klimberg, Kevin J. Boyle, and Ira Yermish -- Data mining applications in higher education / Cali M. Davis ... [et al.] -- Data mining for market segmentation with market share data : a case study approach / Illya Mowerman and Scott J. Lloyd -- An enhancement of the pocket algorithm with ratchet for use in data mining applications / Louis W. Glorfeld and Doug White -- Identification and prediction of chronic conditions for health plan members using data mining techniques / Theodore L. Perry, Stephan Kudyba, and Kenneth D. Lawrence -- Monitoring and managing data and process quality using data mining : business process management for the purchasing and accounts payable processes / Daniel E. O'Leary -- Data mining for individual consumer models and personalized retail promotions / Rayid Ghani ... [et al.] -- Data mining : common definitions, applications, and misunderstandings / Richard D. Pollack -- Fuzzy sets in data mining and ordinal classification / David L. Olson, Helen Moshkovich, and Alexander Mechitov -- Developing an associative keyword space of the data mining literature through latent semantic analysis / Adrian Gardiner -- A classification model for a two-class (new product purchase) discrimination process using multiple-criteria linear programming / Kenneth D. Lawrence ... [et al.].
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    Dimension reduction methods -- Regression modeling -- Multiple regression and model building -- Logistic regression -- Naïve Bayes estimation and Bayesian networks -- Genetic algorithms -- Case study : modeling response to direct mail marketing.
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  • "This hands-on book uses practical examples to illustrate the power of R and data mining. Assuming no prior knowledge of R or data mining/statistical techniques, it covers a diverse set of problems that pose different challenges in terms of size, type of data, goals of analysis, and analytical tools. The main data mining processes and techniques are presented through detailed, real-world case studies. With these case studies, the author supplies all necessary steps, code, and data. Mirroring the do-it-yourself approach of the text, the supporting website provides data sets and R code" -- Provided by publisher.
  • Part 1. Explorations -- Introduction -- Getting Started -- Working with Data -- Loading Data -- Exploring Data -- Interactive Graphics -- Transforming Data -- Part 2. Building Models -- Descriptive and Predictive Analytics -- Cluster Analysis -- Association Analysis -- Decision Trees -- Random Forests -- Boosting -- Support Vector Machines -- Part 3. Delivering Performance -- Model Performance Evaluation -- Deployment -- Part 4. Appendices -- Installing Rattle -- Sample Datasets.
  • Also available: Print – 2006
  • Data preparation for analytics using SAS 2006
    books24x7, SUNet ID login required.
    Pt. 1. Data preparation: business point of view -- ch. 1. Analytic business questions -- Ch. 2. Characteristics of analytic business questions -- Ch. 3. Characteristics of data sources -- Ch. 4. Different points of view on analytic data preparation -- Pt. 2. Data structures and data modeling -- Ch. 5. The origin of data -- Ch. 6. Data models -- Ch. 7. Analysis subjects and multiple observations -- Ch. 8. The one row-per-subject data mart -- Ch. 9. The multiple-rows-per-subject data mart -- Ch. 10. Data structures for longitudinal analysis -- Ch. 11. Considerations for data marts -- Ch. 11. Considerations for predictive modeling -- Pt. 3. Data mart coding and content -- Ch. 13. Accessing data -- Ch. 14. Transposing one- and multiple-rows-per-subject data structures -- Ch. 15. Transposing longitudinal data -- Ch. 16. Transformations of interval-scaled variables -- Ch. 17. Transformations of categorical variables -- Ch. 18. Multiple interval-scaled observations per subject -- Ch. 19. Multiple catagorical observations per subject -- Ch. 20. Coding for predictive modeling -- Ch. 21. Data preparation for multiple-rows-per-subject and longitudinal data marts -- Pt. 4. Sampling, scoring, and automation -- Ch. 22. Sampling -- Ch. 23. Scoring and automation -- Ch 24. Do's and don'ts when building data marts -- Pt. 5. Case studies.
  • Also available: Print – 2007
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  • Small molecule drugs continue to be an important part of medical therapy. However, their use is plagued by the onset of unexpected side effects, often seen only in late-stage clinical trials or after release to the market. As a result, there have been a number of high profile drug withdrawals because of side effects. More worrisome, however, are side effects that result from drug-drug interactions (DDIs). It is very difficult to empirically study DDIs before drugs enter the market because of the small samples of co-prescribed drugs in most late stage clinical drug (Phase III) studies. Some DDIs can be predicted based on knowledge of shared pathways of metabolism--such as when two drugs share a metabolizing enzyme and so the effective levels of one or both drugs are affected by saturation of the enzyme. But many DDIs are more idiosyncratic and difficult to predict. The most difficult cases are those in which two drugs produce a synergistic effect not seen with either drug alone. Thus, I created surveillance methods to detect unexpected DDIs, relying on clinical databases--both electronic medical records and spontaneous adverse event reporting systems. Understanding DDIs has an additional benefit for drug discovery. If two drugs have a synergistic effect, they may shed new light on the molecular mechanisms of their action or of the diseases they treat. If we use a model not of "one drug-one target" but of multiple interacting cellular pathways that respond to drugs ("the network is the target"), then we can leverage DDIs for the study of disease. However, to do this we need new ways to probe and understand these pathways, such as studying the unexpected synergies between drugs in observational reporting systems. Thus it would be extremely valuable to have computational methods that link adverse events to molecular events. The emergence of large databases linking drugs, diseases, drug effects, demographics and genes offers a new opportunity to create informatics methods for greater understanding small molecule effects at the clinical and biological level. I describe studies in which I have shown the great power of integrating these databases. In particular, I used the FDA Adverse Events Reporting System (FDA-AERS) to discover a signal for abnormal glucose in patients taking both paroxetine and pravastatin. Paroxetine is a selective serotonin reuptake inhibitor antidepressant. Pravastatin is an HMG CoA reductase inhibitor cholesterol-lowering drug. Neither is typically associated with hyperglycemia. Based on my analysis of the FDA-AERS, I examined patient electronic medical records in three separate hospitals (Stanford, Harvard, Vanderbilt), and demonstrated a striking increase in glucose levels on patients on both drugs, compared to their glucose levels on only one of the drugs. I also showed that mice on these two drugs have increased glucose. I am working with FDA to consider a potential update to the drug labels. Although this discovery illustrates the power of clinical data mining, the databases I used are filled with biases that make their use treacherous. I believe there are many similarly valuable discoveries to be made in these databases. However, only with careful attention to systematic biases can I ensure that the predictions I make are valid. In this thesis I describe methods to address the major informatics challenges to detecting and understanding the effects of taking multiple drugs at once. In particular, I have shown that I can (1) remove the bias introduced by unmeasured confounding variables, (2) improve the detection of drug interactions in cases of low or even non-reporting, (3) link drug effects to genes through chemical informatics methods, and (4) validate new drug effects using novel retrospective and prospective studies. The work forms an infrastructure that is useful to (1) pharmacogenomics scientists wishing to understand drug action at the molecular level, (2) pharmacologists wishing to better understand the effects of drugs singly and in combination, and (3) regulatory agencies wishing to understand the efficacy and safety of drugs and drug-interactions at a population level.
  • This dissertation develops data-driven methods for healthcare risk modeling to facilitate risk identification and evaluation, focusing on post-marketing drug safety surveillance and breast cancer incidence prediction. For risk identification, we first propose a novel methodology for post-marketing drug safety surveillance: "Follow the money'', which monitors cost in health insurance claims data to detect increased spending related to adverse drug events (ADE). By using real claims data from 2.4 million insured individuals, we demonstrate that this method enables early detection of signals of ADE. Second, we recommend statistical study designs to detect rare and time-dependent ADE resulting from long-term drug use and highlight statistical considerations that drug surveillance designers should focus on when implementing a long-term surveillance. We characterize statistical properties and compare performances of a variety of surveillance designs by applying them to simulated event data as well as real health insurance claims data. For risk evaluation, we develop a stochastic simulation model of the Surveillance, Epidemiology and End Results database to quantify the impact of menopausal hormone therapy (MHT) on U.S. breast cancer incidence. Our model quantifies the promoting effect of MHT on breast tumor growth and the reduced mammographic detectability. By modeling unobservable tumor natural history dynamics and simulating individual life history at a population level, we evaluate the contribution of MHT use cessation to the observed decline in breast cancer incidence between 2002 and 2003. We also predict U.S. breast cancer incidence in the absence of MHT.
  • The structure of the normal brain and its imaging appearance -- The general appearance of edema and hemorrhage on CT, MR and US (including a general introduction to CT, MR and US scanning) -- The basics of contrast and its role in dating -- How the imaging appearance of edema and hemorrhage change over time on CT, MR, and US: dynamic (acute) dating -- Patterns of parenchymal injury: pattern (chronic) dating -- Principles of dynamic dating in the medical legal setting -- Principles of pattern dating in the medical legal setting -- Therefore, what can be said based on the images, and what can't be said based on the images -- The root causes of uncertainty in dating neurologic events based on imaging findings.
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    Good medical practice -- Good prescribing -- Molecular mechanisms of disease -- Immunological factors in disease -- Environmental and nutritional factors in disease -- Principles of infectious disease -- Ageing and disease -- Critical care and emergency medicine -- Poisoning -- Medical psychiatry -- Oncology -- Palliative care and pain management -- Infectious diseases -- Human immunodeficiency virus infection and the human acquired immunodeficiency syndrome -- Sexually transmitted infections -- Clinical biochemistry and metabolism -- Kidney and urinary tract disease -- Cardiovascular disease -- Respiratory disease -- Endocrine disease -- Diabetes mellitus -- Alimentary tract and pancreatic disease -- Liver and biliary tract disease -- Blood disorders -- Musculoskeletal disorders -- Neurological disease -- Skin disease -- Appendix.
  • More than two million medical students, doctors and other health professionals from around the globe have owned a copy of Davidson's Principles and Practice of Medicine since it was first published. Today's readers rely on this beautifully illustrated text to provide up-to-date detail of contemporary medical practice, presented in a style that is concise and yet easy to read. Davidson's provides the factual knowledge required to practise medicine, explaining it in the context of underlying principles, basic science and research evidence, and shows how to apply this knowledge to the management of patients who present with problems rather than specific diseases. The book has won numerous prizes including being highly commended in the British Medical Association book awards. Davidson's global perspective is enhanced by the input of an international team of authors and a distinguished International Advisory Board from 17 countries. Building on the foundations laid down by its original editor, Davidson's remains one of the world's leading and most respected textbooks of medicine. The underlying principles of medicine are described concisely in the first part of the book, and the detailed practice of medicine within each sub-specialty is described in later system-based chapters. Most chapters begin with a two-page overview of the important elements of the clinical examination, including a manikin to illustrate the key steps in the examination of the relevant system. A practical, problem-based clinical approach is described in the 'Presenting Problems' sections, to complement the detailed descriptions of each disease. The text is extensively illustrated, with over 1000 diagrams, clinical photographs, and radiology and pathology images. 1350 text boxes present information in a way suitable for revision, including 150 clinical evidence boxes summarising the results of systematic reviews and randomised controlled trials and 65 'In Old Age' boxes highlighting important aspects of medical practice in the older population. A combined index and glossary of medical acronyms contains over 10 000 subject entries. The contents can also be searched comprehensively as part of the online access to the whole book on the StudentConsult platform. Access over 500 self-testing questions with answers linked to the book's content for further reading. The text uses both SI and non-SI units to make it suitable for readers throughout the globe.
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  • Part 1. Research on Cardiac Surgery and Right Cardiac Catheterization before the Advent of Cardiopulmonary Bypass -- 1. The Discovery of Blood Circulation / Yves Glock -- 2. The History of Surgical Research / Marco Picichè -- 3. The Ignored Birth of Cardiac Surgery: The History of the Surgical Treatment of Heart Wounds and Pericardial Effusions / Vladimir Saplacan, Fabio Cuttone and Massimo Massetti -- 4. The History of Pulmonary Embolectomy Before the Advent of CPB / Marco Vola and Jean-Francois Fuzellier -- 5. Right Cardiac Catheterization Before the Advent of Cardiopulmonary Bypass / Achille Gaspardone and Giulio G. Stefanini -- 6. The History of Mitral and Tricuspid Valve Surgery Before the Advent of Cardiopulmonary Bypass / Luigi Chiariello, Paolo Nardi and Giovanni Alfonso Chiariello -- 7. Surgery of the Aortic Valve Before the Era of Cardiopulmonary Bypass / Y. Glock -- 8. The History of Myocardial Revascularization Before the Advent of Cardiopulmonary Bypass / Marco Picichè -- 9. The History of Experimental Heterotopic and Orthotopic Heart Transplantation Before Cardiopulmonary Bypass / Tyson A. Fricke and Igor E. Konstantinov -- 10. The History of Pediatric Cardiac Surgery Before the Introduction of Extracorporeal Circulation / Alessandro Frigiola -- Part 2. Research on the Cardiopulmonary Bypass Machine -- 11. On the Path to Cardiopulmonary Bypass: From Le Gallois' Experiments to Brukhonenko's Machine / Matthew S. Yong, Stephen B. Horton and Igor E. Konstantinov -- 12. Research on Cardiopulmonary Bypass in North America / Manon Caouette -- 13. From Research on Hibernation and Hypothermia to Recent Advances in Cardiopulmonary Bypass / Isabelle Plamondon and Edoardo Gasparotto -- 14. Cardiac Anaesthesia / Fabio Guarracino and Rubia Baldassarri -- Part 3. Research on Interventional Cardiology and Cardiac Surgery after the Advent of Cardiopulmonary Bypass -- 15. The History of Research on Coronary Angiography and Coronary Angioplasty / Luigi La Vecchia -- 16. Right Cardiac Catheterization After the Advent of Cpb / Achille Gaspardone and Giuilo G. Stefanini -- 17. The History of Research on Coronary Stenting / Fabrizio Tomai and Leonardo De Luca -- 18. The History of Percutaneous Valvuloplasty / Alessandro Fontanelli -- 19. Percutaneous Closure of Atrial and Ventricular Septal Defects / Achille Gaspardone and Giulio G. Stefanini -- 20. Evolution of Homografts and Prosthetic Heart Valves / Marco Picichè -- 21. The History of Research on Mitral, Tricuspid, and Aortic Valve Repair After the Advent of Cardiopulmonary Bypass / Ruggero De Paulis, Andrea Salica, Raffaele Scaffa and Luca Weltert -- 22. History of Research on Myocardial Protection / Victor S. Costache, Cristian Martu, Nicolas Chavanis, Jean Philippe Frieh and Serban Stoica -- 23. Supra-Diaphragmatic Aortic Surgery: Evolution of Material, Techniques and Brain Protection / François Dagenais -- 24. Surgical Treatment of Atrial Fibrillation / Gino Gerosa, Carlo Dal Lin and Vincenzo Tarzia -- 25. Catheter Ablation of Atrial Fibrillation / Alessio Marinelli and Domenico Corrado -- 26. The History of Cardiac Pacemakers and Defibrillators / Serge Boveda, Stéphane Garrigue and Philippe Ritter -- 27. The History of Surgery for Ischemic Heart Disease and Mechanical Complications of Myocardial Infarction After the Advent of CPB / Roland G. Demaria and Mohammed Al Yamani -- 28. Progress and Milestones in the Treatment of Deep Sternal Wound Infections / Richard Baillot and Daniel Cloutier -- 29. Engineering for IABP and ECMO / Roberto Lorusso, Attilio Renzulli and Sandro Gelsomino -- 30. The History of Research on Ventricular Assist Devices and Total Artificial Heart / Luc M. Jacquet -- 31. The History of Research on Adult and Paediatric Heart Transplantation / Johann U. Brink and Yves d'Udekem -- 32. The History of Pediatric Cardiac Surgery After the Advent of Cardiopulmonary Bypass / Jean E. Rubay -- 33. Minimally Invasive and Robotic Cardiac Surgery / Loris Salvador -- 34. The History of Research on Percutaneous, Transapical, and Sutureless Aortic Valve Replacement / Thierry Aymard and Thierry Carrel. -- 35. Erratum to: The History of Research on Percutaneous, Transapical, and Sutureless Aortic Valve Replacement / Thierry Aymard and Thierry Carrel.
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  • Preface -- Introduction -- 1. Preparing a scientific presentation -- 2. The structure of a scientific presentation -- 3. Visual displays: how to (and not to) use them -- 4. Delivery -- App. A Checklist for presentations -- App. B Evaluation form.
  • 1. DC servo systems defined -- 2. Anatomy of a continuous-time DC servo -- 3. DC motors in servo systems -- 4. Feedback control systems -- 5. Proportional control of a second-order DC servo -- 6. Compensation of a continuous-time DC servo -- 7. DC servo amplifiers and shaft encoders -- 8. Control of a position servo using a PIC microcontroller.
  • Also available: Print – 2011
    Part A. Report of WHO expert consultation on DDT rish characterization -- 1. Introduction -- 2. Consensus statement -- Part B. Hazard and exposure assessments -- 1. Summary and conclusions -- 2. Chemical identity -- 3. Exposure sources and metrics -- 4. Kinetics and metabolism -- 5. Hepatic effects and enzyme induction -- 6. Neurotoxicity -- 7. Immunotoxicity -- 8. Carcinogenicity -- 9. Genotoxicity -- 10. Endocrinological and reproductive effects -- 11. Hazard characterization -- 12. Exposure assessment.
  • De genetica medica v. 1-5, 1961-.
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  • This website presents Andreas Vesalius' Renaissance anatomical atlas On the Fabric of the Human Body (1543, 1555) in an exciting new way and explains the work in progress at Northwestern University to translate and annotate this historic work.
  • Although cancer types vary widely, the number of new cancer drugs each year is severely limited. Even for those cancer therapies which are currently in use, prognostic outcomes vary significantly across cancer types. Drug discovery relies primarily on our knowledge of direct drug targets, but not the systematic off-target effects that these therapies may have. As a result, our knowledge of these drugs is somewhat limited to general mechanistic classes. Within these classes it is hard to find potential patient differences without time-intensive studies and trials. While drug classification relies on our knowledge of direct targets, it does not typically consider how a number of global cellular processes are ultimately affected. Quantifying the mechanistic differences between drugs is a difficult process. Current standards to quantify individual drug efficacy are large-scale measurements are taken at a heterogeneous population level, ignoring the effects of drug action or mechanism in single cells or cell populations. Because our knowledge is limited in this way, we are often surprised to find that similarly classified cancer drugs can have disparate effects in patients. Single-cell technologies including flow cytometry allow us to uncover relationships between drugs through simultaneous measurement of cell signal, cell cycle and cell type for each cell. Recent technological advances in flow cytometry have facilitated new clinical tests to determine cancer subtypes. In addition, these methodological advances have created potential for providing novel insights into drug mechanism and patient response. In this dissertation, I describe a new framework for performing mechanistic profiling of cancer cells. There are two facets of this problem. The first is an understanding of cancer cell cycle. Prior to treating with a drug, it is important to form a general model of how a cancer cell replicates. In a screening methodology, however, this is a difficult problem. I address this problem by building an automated, de novo model of cell cycle. Second, I perform cancer therapeutic profiling by measuring DNA damage, apoptosis, cell cycle, and cell signaling markers across multiple cancer cell types. In this thesis, I combine both cell cycle and drug profiling methods into a new drug profiling framework that can be used to find existing and novel cell cycle and drug-based biology. The results of our current work have major implications for use in profiling aberrant cell types in primary cancer samples, as well as mechanistic drug screening.
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    Despite advances in health care, infectious microbes continue to be a formidable adversary to scientists and doctors. Vaccines and antibiotics, the mainstays of modern medicine, have not been able to conquer infectious microbes because of their amazing ability to adapt, evolve, and spread to new places. Terrorism aside, one of the greatest dangers from infectious disease we face today is from a massive outbreak of drug-resistant microbes. Deadly Outbreaks recounts the scientific adventures of a special group of intrepid individuals who investigate these outbreaks around the world and figure out how to stop them. Part homicide detective, part physician, these medical investigators must view the problem from every angle, exhausting every possible source of contamination. Any data gathered in the field must be stripped of human sorrows and carefully analyzed into hard statistics. -- Jacket.
  • Deafness 2013
    Deafness explores the neuronal consequences of being deaf on the peripheral and the central nervous system as well as on cognition and learning, viewed from the standpoint of genetics, neuroanatomy and neurophysiology, molecular biology, systems neuroscience, and cognitive neuroscience.
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    Why you need to use statistics in your research -- Understanding statistical language -- Linking data collection with analysis -- Presenting data -- Describing data -- Inferring differences and relationships from data -- What next? -- Appendix 1: Asking questions and types of data -- Appendix 2: Useful statistical software -- Appendix 3: An alphabet of statistics.
  • Death and Dying in Modern Britain -- Palliative Care Philosophy and Practice -- Hospice Development in the UK -- Spirituality -- Understanding Grief -- Supporting Bereaved People -- Issues for Policy and Practice.
  • Miller and Truog challenge fundamental doctrines of established medical ethics. They argue systematically that physicians legitimately cause the death of patients in the routine practices of withdrawing life support and vital organ donation.
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    "The true story of the war on cancer from one of its generals In The Death of Cancer, Dr. Vincent T. DeVita Jr.--former director of the National Cancer Institute, former physician-in-chief at Memorial Sloan Kettering, director of the Yale Cancer Center, former president of the American Cancer Society, and developer of the first successful chemotherapy treatment for Hodgkin's lymphoma, which first demonstrated that advanced cancers of a major organ system in adults could be cured by chemotherapy--provides a personal history of one of the greatest science stories of our time, covering our fight against cancer from a man who's seen it all. But this is more than a history; it's also a work of advocacy. Despite declining mortality rates, DeVita argues, America's cancer patients are being shortchanged by timid doctors, misguided national agendas, and compromised bureaucracies. He gives readers an eye-opening look at the strengths and weaknesses of America's most prestigious cancer centers, showing how patients can use this information to their advantage. Though we're rapidly approaching total victory over cancer, he contends, we need to do more to synthesize our progress and help doctors put it into practice. This is an ambitious book about a life-or-death subject, a vital entry into the cancer literature genre. With historical depth and authenticity, DeVita brings important information to readers about what cancer is, how best to fight it, and what we still have to learn"-- Provided by publisher.
  • Also available: Print – 2009
    The role of TNF in cancer / Harald Wajant -- Many checkpoints on the road to cell death: regulation of Fas-FasL interactions and Fas signaling in peripheral immune responses / Madhu Ramaswamy ... [et al.] -- FasL expression and reverse signaling / M. Lettau ... [et al.] -- Impact of TNF-R1 and CD95 internalization on apoptotic and antiapoptotic signaling / Stefan Schütze and Wulf Schneider-Brachert -- Ubiquitination and TNFR1 signaling / Ken-ichi Fujita and Srinivasa M. Srinivasula -- From biochemical principles of apoptosis induction by TRAIL to application in tumour therapy / Stefanie M. Cordier, Kerstin Papenfuss, and Henning Walczak -- Therapeutic targeting of TWEAK/Fn14 in cancer: exploiting the intrinsic tumor cell killing capacity of the pathway / Jennifer S. Michaelson and Linda C. Burkly -- APRIL in B-cell malignancies and autoimmunity / Fiona C. Kimberly, Jan Paul Medema, and Michael Hahne -- Autophagy in cancer and chemotherapy / Shida Yousefi and Hans-Uwe Simon -- Glucocorticoid-mediated apoptosis resistance of solid tumors / Ingrid Herr, Markus W. Büchler, and Jürgen Mattern -- Targeting death-receptors in radiation therapy / Olivier Niemöller and Claus Belka -- Death ligands designed to kill: development and application of targeted cancer therapeutics based on proapoptotic TNF family ligands / Jeannette Gerspach, Harald Wajant, and Klaus Pfizenmaier.
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    As we think about death -- What is death? -- The death system -- Dying -- Hospice and palliative care -- End-of-life issues and decisions -- Suicide -- Violent death : murder, terrorism, genocide, disaster, and accident -- Euthanasia, assisted death, abortion, and the right to die -- Death in the world of childhood -- Bereavement, grief, and mourning -- The funeral process -- Do we survive death? -- How can we help? -- Good life, good death?
  • 1. A pragmatic method -- 2. A pragmatic framework of values and principles: the beginning -- 3. Defining and valuing properties and individuals -- 4. What harm does death do to the decedent? -- 5. How should we feel about our own death? -- 6. How should we feel about another's death? -- 7. Is there a duty to die? -- 8. A duty to suicide -- Index.
  • Current economic, demographic, and environmental shifts are presenting major challenges to health care systems around the world. In response, decentralization--the transfer of control from central to local authorities--is emerging as a successful means of meeting these challenges and reducing inequities of care. But as with health care itself, one size does not fit all, and care systems must be responsive to global reality as well as local demand. Decentralizing Health Services explores a variety of applications of decentralization to health care delivery in both the developing and developed worlds. Outfitted with principles, blueprints, and examples, this ambitious text clearly sets out the potential role of decentralized care as a major player in public health. Its models of service delivery illustrate care that is effective, inclusive, flexible, and in tune with the current era of preventive and evidence-based healthcare. Contributors point out opportunities, caveats, and controversies as they: Clarify the relationships among decentralization, politics, and policy Differentiate between political, fiscal, and administrative decentralization in health care systems. Consider public/private partnerships in health systems. Explain how the effects of decentralization can be evaluated. Present the newest data on the health outcomes of decentralization. Explore some challenges and global issues of health systems in the 21st century. And each chapter features learning goals, discussion questions, activities, and recommendations for further reading. Heralding changes poised to revolutionize care, Decentralizing Health Services will broaden the horizons of researchers and administrators in health services, health economics, and health policy.
  • Deciphering growth 2005
  • Limb threatening trauma to the leg may be treated with either limb salvage (retention process) or amputation (prosthetic process). Limb salvage allows the patient to keep his leg and avoid using a prosthetic; however, it typically has higher probabilities than amputation of complications, additional time in the hospital, and chronic pain. The optimal treatment is still under debate and the current methods to make the decision do not explicitly incorporate the patient's preferences or the patient's medical insurance. This dissertation develops a decision analysis model to help a patient think clearly about the retention process vs. the prosthetic process. The model updates conditional probabilities of various outcomes based on the patient's demographics and develops a method to explicitly incorporate the patient's preferences for keeping the leg, avoiding chronic pain, and avoiding time in the hospital. The model also calculates the probabilities of hospital and prosthetic costs for the patient's health insurance and risk attitude. The decision analysis model in this dissertation utilizes preferences from the patient to inform the decision, facilitates effective discussions between the doctor and the patient, and provides a comprehensive recommendation to the patient.
  • This well-established international series examines major areas of basic and clinical research within neuroscience, as well as emerging and promising subfields.This volume explores interdisciplinary research on decision making taking a neural and behavioural approach *Leading authors review the state-of-the-art in their field of investigation, and provide their views and perspectives for future research *Chapters are extensively referenced to provide readers with a comprehensive list of resources on the topics covered *All chapters include comprehensive background information and are written in a clear form that is also accessible to the non-specialist.
  • "The art and science of spinal surgery has been in constant evolution since the early middle ages. The majority of advances, however, have occurred after World War II with the advent of antibiotics, better imaging, improved diagnostic methods, and surgical care. In the past five to ten years, a greater understanding of spinal anatomy and the development of more sophisticated radiological imaging and instrumentation have further illuminated what is possible in spinal care. Decision Making in Minimally Invasive Spine Surgery adds to the historical continuum by compiling a collection of chapters that define why a minimally invasive approach should be chosen and how to perform such a procedure, written by authors who have established themselves as experts in the field"--Provided by publisher.
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  • Decision making in neurocritical care 2009
    Thieme eNeurosurgery
    From important aspects of the physical examination to imaging studies to treatment options and dosage guidelines, this book provides a solid introduction to the evidence-based management of patients in the neurological intensive care unit. Succinct text in a highly accessible bullet-point format details the essentials of history-taking, physical examination, differential diagnosis, diagnostic evaluation, and treatments for a range of neurological problems in the critical care setting.
  • v. 2, 2011 Springer
  • "Decision Making in Spinal Care, 2nd Edition presents current management strategies for the most common spine problems, including trauma injuries, metabolic and degenerative diseases, and spinal deformities. Each chapter opens with a concise introduction to the topic and discussion of the classification of the injury, condition, or management approach. The authors then describe the diagnostic workup of the patient, the treatment options available, the likely outcome, and possible complications. Chapters also include useful decision making algorithms"--Provided by publisher.
  • A look at the recent oncology literature or a search of one of the common databases reveals a steadily increasing number of nomograms and other prognostic models, some of which are also available in the form of web-based tools. These models may predict the risk of relapse, lymphatic spread of a given malignancy, toxicity, survival, et cetera Pathology information, gene signatures, and clinical data may all be used to compute the models. This trend reflects increasingly individualized treatment concepts and also the need for approaches that achieve a favorable balance between effectiveness and side-effects. Moreover, optimal resource utilization requires prognostic knowledge, for example to avoid lengthy and aggressive treatment courses in patients with a short survival expectation. In order to avoid misuse, it is important to understand the limits and caveats of prognostic and predictive models. This book provides a comprehensive overview of such decision tools for radiation oncology, stratified by disease site, which will enable readers to make informed choices in daily clinical practice and to critically follow the future development of new tools in the field.
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    Bloodletting and inflammation -- Bloodletting and social norms -- Disease and causes of disease in early nineteenth century medical thought -- The Early nineteenth century conception of quackery -- The Edinburgh bloodletting controversy -- Ignaz Semmelweis and the adoption of etiological concepts of disease -- The Collapse of traditional medicine and the rise of medical science -- The Current crisis in epidemiology.
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    Preface: the sacred part -- Methodological introduction: a strategy and protocol of deconstruction -- Dignity and sanctity -- Dignity and sovereignty -- Human dignity from Cicero to Kant -- The right to die: mapping a contemporary debate -- Suicide and sacrifice from Plato to Kant -- Sacrifice and the right to die -- A debate deconstructed.
  • This thesis is composed of experimental and analytic work deconstructing the cerebellar learning algorithm. The central finding is that two parallel neural circuits, with independent instructive signals, support cerebellum-dependent learning. An analytic framework for this result, based on overcoming signal-dependent noise, is proposed.
  • The ultimate goal of regenerative medicine is to repair tissues damaged by aging, injury or disease. Tissue-specific adult stem cells constitute a reservoir of cells in postnatal tissue that have the remarkable capacity to proliferate and repair tissue damage because they can both self-renew, or produce more stem cells, and differentiate into mature cells. Adult stem cells have been identified in a variety of tissues, including blood, brain, skin, intestine, and muscle and methods exist to prospectively isolate these populations by flow cytometry. Upon transplantation, they possess an extraordinary ability to contribute extensively to tissue regeneration. Notably, adult stem cells are a relatively rare cell population and methods to propagate and expand these cell types in culture without loss of regenerative capacity are lacking, a hurdle to their clinical use. In vivo, stem cells reside in an instructive microenvironment, or niche, which serves to regulate fate decisions, including quiescence, self-renewal, and differentiation. Given the complexity of their native environment, it is not surprising that upon removal from their niche they rapidly lose regenerative capacity. While the role of biochemical signals in regulating stem cell fate and function has been widely explored, the effects of biophysical signals have not been discerned. To elucidate the role of matrix elasticity in regulating adult stem cell fate, we first design a biomimetic hydrogel culture platform to mimic tissue elasticity and physiologic presentation of biochemical cues. Adapting a previously described conjugate addition reaction, poly(ethylene glycol) hydrogel substrates are fabricated which have a Young's modulus that is tunable in the physiologic range (1-50kPa). Gels are designed to have limited post-polymerization swelling to enable constant density of tethered biological ligands. Utilizing this tunable hydrogel culture platform, we provide the first definitive evidence that matrix elasticity regulates adult stem cell self-renewal in culture. Using a combination of culture studies and in vivo functional assays in mice, we demonstrate that substrate rigidity profoundly impacts the self-renewal potential of tissue-specific adult stem cells isolated from skeletal muscle and bone marrow. In contrast with rigid tissue culture plastic in which regenerative potential is lost, we demonstrate that culture on a pliant hydrogel substrate maintains the 'stemness' of muscle stem cells (MuSCs) and hematopoetic stem cells (HSCs). Further, we describe a novel in vivo screen and identify an extracellular matrix molecule which, in conjunction with soft hydrogel, has a previously unrecognized role in regulating HSC fate. These studies demonstrate that recapitulating tissue rigidity, a key component of the in vivo microenvironment, enables propagation of functional adult stem cells in culture for the first time. We expect these experimental approaches will be broadly applicable to other adult stem cell types and ultimately will profoundly impact regenerative medicine by enabling generation of functional stem cell populations for use in clinical cell-based therapies.
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  • Basic Principles of Deep Brain Stimulation / F. L. H. Gielen and G. C. Molnar -- Neural Circuits Affected by Deep Brain Stimulation for the Treatment of Psychiatric Disorders / Suzanne N. Haber and Benjamin D. Greenberg -- Mechanisms of Action of Deep Brain Stimulation for the Treatment of Psychiatric Disorders / J. Luis Lujan and Cameron C. McIntyre -- Deep Brain Stimulation in the Ventral Capsule/Ventral Striatum for the Treatment of Obsessive-Compulsive Disorder: Role of the Bed Nucleus of the Stria Terminalis / Loes Gabriëls and Bart Nuttin -- Deep Brain Stimulation in Obsessive-Compulsive Disorder Targeted at the Nucleus Accumbens / Pelle P. de Koning, Pepijn van den Munckhof, Martijn Figee, Rick Schuurman and Damiaan Denys -- What is the Role of the Subthalamic Nucleus in Obsessive-Compulsive Disorder? Elements and Insights from Deep Brain Stimulation Studies / William I. A. Haynes and Luc Mallet -- Obsessive-Compulsive Disorders in Animals / Christine Winter -- Subcallosal Cingulate Cortex Deep Brain Stimulation for the Treatment of Refractory Mood Disorders: Evidence and Challenges / Peter Giacobbe, Nir Lipsman and Andres M. Lozano -- Deep Brain Stimulation of the Human Reward System as a Putative Treatment for Refractory Major Depression / T. E. Schlaepfer, V. A. Coenen and B. H. Bewernick -- Depression in Humans: The Ventral Capsule/Ventral Striatum / Mayur Pandya, Andre Machado and Donald Malone -- Deep Brain Stimulation in Animal Models of Depression / Brian W. Scott, José N. Nobrega and Clement Hamani -- Deep Brain Stimulation in Tourette Syndrome / L. Ackermans, I. Neuner, J. Kuhn and V. Visser-Vandewalle -- Surgical Treatments for Drug Addictions in Humans / Bomin Sun and Wei Liu -- Manipulating Addictive Behaviour in Animal Models / Rolinka M. C. Schippers, Tommy Pattij and Taco J. De Vries -- Neuropsychiatric Side Effects of Deep Brain Stimulation in Parkinson's Disease / Christine Daniels and Jens Volkmann -- Psychiatric Aspects of Parkinson's Disease in Animal Models of Deep Brain Stimulation of the Subthalamic Nucleus / S. K. H. Tan, H. Hartung, V. Visser-Vandewalle, T. Sharp and Y. Temel -- Scientific Recordings in Deep Brain Stimulation / Michael X. Cohen -- Neurotransmitter Release During Deep Brain Stimulation / Osama A. Abulseoud, Emily J. Knight and Kendall H. Lee -- The Potential Role of Nonneuronal Cells in the Deep Brain Stimulation Mechanism: What Are Glia? What Are Their Functions? Could They Be Players in Deep Brain Stimulation? / Vinata Vedam-Mai, Michael S. Okun and Elly M. Hol -- Animal Studies in Deep Brain Stimulation Research / Matthijs G. P. Feenstra and Damiaan Denys -- Neuroimaging Deep Brain Stimulation in Psychiatric Disorders / Martijn Figee, Pepijn van den Munckhof, Rick Schuurman and Damiaan Denys -- Optogenetic Strategies for the Treatment of Neuropsychiatric Disorders: Circuit-Function Analysis and Clinical Implications / Daniel L. Albaugh and Garret D. Stuber -- Next-Generation Electrodes for Steering Brain Stimulation / H. C. F. Martens, M. M. J. Decré and E. Toader -- Future Applications: Nanotechniques / Russell J. Andrews, Jessica E. Koehne and Meyya Meyyappan -- Ethical Guidance for the Use of Deep Brain Stimulation in Psychiatric Trials and Emerging Uses: Review and Reflections / Emily Bell and Eric Racine -- History of "Psychiatric" Deep Brain Stimulation: A Critical Appraisal / Marwan I. Hariz.
  • Chronic electrical stimulation of the brain has become a standard surgical therapy for Parkinson's disease, with many studies demonstrating excellent outcomes without any serious complications. Recently this surgical intervention has also been applied to various other neurological diseases, such as involuntary movement disorders, intractable pain, and psychological conditions including depression and obsessive-compulsive disorder. This comprehensive, up-to-date textbook will meet the needs of all who wish to learn more about the application of deep brain stimulation and will provide a sound basis for safe and accurate surgery. The book comprises two main parts, the first of which presents relevant anatomical and functional background information on the basal ganglia, thalamus, and other brain structures as well as on the mechanism of brain stimulation. The second part describes clinical studies on deep brain stimulation, covering results in a range of movement disorders and psychiatric diseases and also important aspects of instrumentation and technique. The authors are outstanding scientists and experts in the field from across the world. This book will be welcomed by all young neurosurgeons, neurologists, psychiatrists, and other medical staff who are interested in electrical stimulation of the brain for the treatment of neurological disorders.
  • Introduction / Paola De Nardi and Stefano Ferrari -- Diagnosis / Paola De Nardi and Stefano Ferrari -- Treatment / Paola De Nardi and Stefano Ferrari -- The Experience of Living with Endometriosis / Elaine Denny.
  • Deep sequencing data analysis 2013
    Springer Protocols
    Introduction to high-throughput sequencing experiments : design and bioinformatics analysis / Rachelly Normand and Itai Yanai -- Compressing resequencing data with GReEn / Armando J. Pinho, Diogo Pratas, and Sara P. Garcia -- On the accuracy of short read mapping / Peter Menzel ... [et al.] -- Statistical modeling of coverage in high-throughput data / David Golan and Saharon Rosset -- Assembly algorithms for deep sequencing data : basics and pitfalls / Nitzan Kol and Noam Shomron -- Short read mapping for exome sequencing / Xueya Zhou ... [et al.] -- Profiling short tandem repeats from short reads / Melissa Gymrek and Yaniv Erlich -- Exome sequencing analysis : a guide to disease variant detection / Ofer Isakov, Marie Perrone, and Noam Shomron -- Identifying RNA editing sites in miRNAs by deep sequencing / Shahar Alon and Eli Eisenberg -- Identifying differential alternative splicing events from RNA sequencing data using RNASeq-MATS / Juw Won Park ... [et al.] -- Optimizing detection of transcription factor-binding sites in ChIP-seq experiments / Aleksi Kallio and Laura L. Elo -- Statistical analysis of ChIP-seq data with MOSAiCS / Guannan Sun ... [et al.] -- Detection of reverse transcriptase termination sites using cDNA ligation and massive parallel sequencing / Lukasz J. Kielpinski ... [et al.].
  • Also available: Print – 2005
  • Meniscal degeneration often precedes cartilage degeneration, and effective detection and treatment can be critical in preventing osteoarthritis. The meniscus is a heterogeneous tissue, and obtaining information on the varying characteristics of meniscal regions is important in investigating such strategies. However, no current method exists that can detect such meniscal heterogeneity in the tissue matrix. In addition, the lack of quantitative information on meniscal heterogeneity hinders the development an effective, long-term solution that can treat degeneration in the meniscus. The purpose of this dissertation was thus 1) to find quantitative characteristics that defined meniscal heterogeneity and 2) to evaluate non-invasive diagnostic methods that could reflect the matrix tissue properties and detect meniscal heterogeneity. To accomplish the first goal, gene expression profiles of meniscal cells were statistically analyzed to identify quantitative markers that could distinguish between different regions of the meniscus, describing its heterogeneous properties. This information was then used to evaluate cell sources for meniscal tissue engineering, demonstrating the potential application of these quantitative markers in developing an effective treatment for meniscal degeneration. Secondly, in order to detect meniscal heterogeneity, which is reflected in the changing tissue properties within the tissue, magnetic resonance imaging was used. The potential of the imaging parameters T1[rho] and T2 relaxation times in detecting various meniscal tissue properties, including the matrix composition and mechanical properties, was examined. Ultimately, such information would be useful in identifying internal degenerative changes that take place in the matrix of the tissue prior to macroscopic injuries. In this study, both T1[rho] and T2 relaxation times showed variation with tissue properties but were highly correlated with one another, indicating that only one imaging parameter might be necessary as a diagnostic tool in a clinical setting. In addition, an exploratory aim visualized the internal secondary collagen network in the meniscus and examined its deformation in different mechanical loading positions. This work significantly adds to the understanding of the heterogeneous properties of the meniscus and the potential of magnetic resonance imaging parameters as detection markers. It contributes to the advancement of diagnosis and treatment strategies for meniscal degeneration, which has further implications for preventing osteoarthritis progression.
  • Glioblastoma multiforme (GBM) is the most common and deadly primary brain tumor. Amplification and rearrangements of the epidermal growth factor receptor (EGFR) gene are frequently found in GBM, and the most common variant is EGFRvIII. Here we report that EGFRvIII is a novel cancer stem cell (CSC) or tumor initiating cell marker in GBM. EGFRvIII expression is restricted to sub-regions and sporadic cells within the tumor and EGFRvIII is frequently co-expressed in the putative CSC CD133+ population. EGFRvIII gene and protein expression can be maintained when primary GBM are cultured as tumor derived neurospheres and is lost when spheres are exposed to differentiating conditions. Furthermore, cells that express both EGFRvIII and CD133 display the greatest self-renewal and tumor initiating abilities when compared to the single positive or double negative populations. If amplification and rearrangement are early events in tumorigenesis, this implies that they should be preserved across the tumor despite focal expression. Unexpectedly, we found EGFR amplification and rearrangement throughout the tumor, including regions with no EGFRvIII expression. To study this phenomenon, we characterized three GBM cell lines with endogenous EGFRvIII expression. EGFRvIII defined a hierarchy and epigenetic mechanisms played a role in maintaining heterogeneous EGFRvIII expression, suggesting that drugs which modulate the epigenome might be used successfully in glioblastoma tumors. To assess a broad applicability of our findings to other tumor types, we investigated EGFRvIII expression and amplification in primary breast carcinoma. Our analyses confirmed the presence of EGFRvIII, but in the absence of amplification or rearrangement of the EGFR locus. Interestingly, EGFRvIII was often expressed in a subset of tumor cells and was co-expressed in the putative CSC CD44+/CD24-/low population. EGFRvIII-expressing cells had increased expression of stem cell and epithelial-mesenchymal transition (EMT) associated genes and increased in vitro sphere formation and in vivo tumor formation compared to non-expressing cells. Mechanistically, EGFRvIII mediated its effects through the Wnt/[beta]-catenin pathway. Collectively, this data suggests a novel function for EGFRvIII in tumorigenesis and further supports the use of EGFRvIII-targeted therapy in these tumor types.
  • Prevention Science: An Epidemiological Approach -- Individual Physical, Cognitive, and Emotional Vulnerability Across the Life Course: Benchmarks and Developmental Challenges -- Benchmarks, Developmental Challenges, and Risks During the Prenatal and Infancy Period -- Childhood and the Entry into Adolescence: A Pivotal Period in Health-Related Behaviors and Prevention -- Adolescence and Early Adulthood -- Stressors and Vulnerabilities in Middle and Old Age: Opportunities for Prevention -- Environmental Influences and Implications for Intervention Development -- Family -- School Influences on Child and Youth Development -- Peer Networks -- Risk and Resilience Processes in Single-Mother Families: An Interactionist Perspective -- Environmental Influences: The Workplace and Mental Health-Models, Vulnerability Factors, and Interventions -- An Integrated Prevention Science Model: A Conceptual Foundation for Prevention Research -- Design of Prevention Interventions -- Implementation Science and the Effective Delivery of Evidence-Based Prevention -- Factors Affecting Implementation: Cultural Adaptation and Training -- Measuring Fidelity -- Research Design -- Translating the Intervention Approach into an Appropriate Research Design: The Next-Generation Adaptive Designs for Effectiveness and Implementation Research -- The Epidemiologic Case-Crossover and Case-Control Approaches in Prevention Research -- The Use of Simulation Models in Public Health with Applications to Substance Abuse and Obesity Problems -- Meta-analysis in Prevention Science -- Mixed Methods Research Design for Prevention Science: Methods, Critiques, and Recommendations -- Analytic Methods -- Latent Class Analysis in Prevention Science -- Discrete-Time Survival Analysis in Prevention Science -- Using Mediation and Moderation Analyses to Enhance Prevention Research -- Advances in Missing Data Models and Fidelity Issues of Implementing These Methods in Prevention Science -- Cost Analysis and Policy -- Economic Analysis and Policy Studies: Special Challenges in the Prevention Sciences -- Strengthening Prevention Science to Ensure Effectiveness of Intervention in Practice: Setting up an International Agenda.
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  • Segmentation of anatomical structures in medical image data is an essential task in clinical practice. Dagmar Kainmueller introduces methods for accurate fully automatic segmentation of anatomical structures in 3D medical image data. The author's core methodological contribution is a novel deformation model that overcomes limitations of state-of-the-art Deformable Surface approaches, hence allowing for accurate segmentation of tip- and ridge-shaped features of anatomical structures. As for practical contributions, she proposes application-specific segmentation pipelines for a range of anatomical structures, together with thorough evaluations of segmentation accuracy on clinical image data. As compared to related work, these fully automatic pipelines allow for highly accurate segmentation of benchmark image data. Contents Deformable Meshes for Accurate Automatic Segmentation Omnidirectional Displacements for Deformable Surfaces (ODDS) Coupled Deformable Surfaces for Multi-object Segmentation From Surface Mesh Deformations to Volume Deformations Segmentation of Anatomical Structures in Medical Image Data Target Groups Academics and practitioners in the fields of computer science, medical imaging, and automatic segmentation. The Author Dagmar Kainmueller works as a research scientist at the Max Planck Institute of Molecular Cell Biology and Genetics in Dresden, Germany, with a focus on bio image analysis. The Editor The series Aktuelle Forschung Medizintechnik - Latest Research in Medical Engineering is edited by Thorsten M. Buzug.
  • "With rapid advancement in technology and materials in total knee arthroplasty (TKA), long-term survival and function of the total knee is now more and more dependent on restoring accurate limb alignment, precise component position and optimum soft-tissue balance. Proper technique is key to ensuring this and is all the more crucial and challenging to achieve in arthritic knees with severe and complex deformities. Correction of such knee deformities forms an important part of TKA for orthopedic surgeons working in both emerging and developed nations. Deformity Correction in Total Knee Arthroplasty fills the void that exists in treating severe and complex knee deformities and the use of computer-navigation in TKA. It covers the principles of deformity correction and soft-tissue balancing in primary TKA in an illustrative, step-wise and algorithmic fashion. Starting with the initial key step of preoperative planning, this book goes on to specifically describe how to deal with different types of deformities encountered in patients who undergo TKA - varus, valgus, flexion, hypertension, rotational and extra-articular deformities - as well as the stiff knee, the unstable knee, osteotomies in primary TKA and postoperative pain management and rehabilitation. This focused how-to manual includes plentiful images and clear, concise text from authors who have performed thousands of TKAs, making it a must-have reference for any surgeon unfamiliar or frequently confronted with this type of procedure."--Publisher's website.
  • Diagnosis -- History taking and the medical record -- The screening physical examination -- Vital signs, anthropometric data, and pain -- Non-regional systems and diseases -- The skin and nails -- The head and neck -- The chest : chest wall, pulmonary, and cardiovascular systems; the breasts -- Abdomen, perineum, anus, and rectosigmoid -- The urinary system -- The female genitalia and reproductive system -- Male genitalia and reproductive system -- The spine, pelvis and extremities -- The nervous system -- The mental status, psychiatric, and social evaluations -- The preoperative evaluation -- Principles of diagnostic testing -- Common laboratory tests.
  • Also available: Print – 2009
    Diagnosis -- History taking and the medical record -- The screening physical examination -- Vital signs, anthropometric data, and pain -- Non-regional systems and diseases -- The skin and nails -- The head and neck -- The chest : chest wall, pulmonary, and cardiovascular systems; the breasts -- Abdomen, perineum, anus, and rectosigmoid -- The urinary system -- The female genitalia and reproductive system -- Male genitalia and reproductive system -- The spine, pelvis and extremities -- The neurologic examination -- The mental status, psychiatric, and social evaluations -- The preoperative evaluation -- Principles of diagnostic testing -- Common laboratory tests.
  • Osteoarthritis is a debilitating disease that affects 27 million Americans. Major risk factors for osteoarthritis include mechanical injury and obesity. Prolonged exposure to mechanical overload in the knee joint, either by injury, malalignment, or obesity, is associated with early onset of osteoarthritis. Recent evidence demonstrates that adipose tissue is a metabolically active and produces systemic biofactors known as adipokines associated with numerous diseases including cardiovascular disease, hypertension, insulin resistance, rheumatoid arthritis, and osteoarthritis. Interestingly, obesity is a significant risk factor for hand osteoarthritis, suggesting a biologic link between obesity and osteoarthritis that is perhaps mediated through adipokines. While many studies investigating in vitro osteoarthritic degradation have focused on cartilage tissue, the menisci has received relatively little attention despite it's important functional role in joint stability and load transfer in the knee. The purpose of this thesis was to explore the relative susceptibility of cartilage and meniscal tissue degradation to in vitro mechanical overload and adipokine exposure using an immature bovine tissue explant model. To explore the injury response, explants of cartilage and meniscal tissues were compressed at various strain rates to create a spectrum of peak injury forces and cultured for up to nine days post-injury. To investigate whether adipose tissue and adipokines can biochemically induce changes in cartilage and meniscal tissues, explants of cartilage and meniscal tissue were incubated with infrapatellar fat pad or individual adipokines and assessed for altered matrix metabolism. Overall, results indicate that, while mechanically robust, meniscal tissue is vulnerable to biologic damage induced by mechanical overload and adipokines. We also demonstrate for the first time that meniscal tissue is more catabolically sensitive to adipokines than cartilage tissue. These results provide evidence that obesity-driven degradation of knee joint could be biochemically mediated and suggest meniscal degradation as a possible early event in osteoarthritis development.
  • Introduction -- Overview of the nervous system -- The neurologic history -- The general physical examination -- General outline of the neurologic examination -- Gross and microscopic anatomy of the cerebral hemispheres -- Functions of the central cortex and regional cerebral diagnosis -- The mental status examination -- Disorders of speech and language -- Agnosia, apraxia, and related disorders of higher cortical function -- An overview of brainstem and cranial nerve anatomy -- The olfactory nerve -- The optic nerve -- The ocular motor nerves -- The trigeminal nerve -- The facial nerve -- The acoustic (vestibulocochlear) nerve -- The glossopharyngeal and vagus nerves -- The spinal accessory nerve -- The hypoglossal nerve -- Brainstem and multiple cranial nerve syndromes -- Overview of the motor system -- The motor unit level -- The spinal cord level -- The corticospinal (pyramidal) level -- The extrapyramidal level -- Motor strength and power -- Muscle tone -- Muscle volume and contour -- Abnormalities of movement -- Overview of the sensory system -- The exteroceptive sensations -- The proprioceptive sensations -- The interoceptive, or visceral, sensations -- Cerebral sensory functions -- Sensory localization -- Introduction to the reflexes -- The deep tendon or muscle stretch reflexes -- The superficial (cutaneous) reflexes -- Pathologic reflexes -- Postural and righting reflexes -- Associated movements -- Cerebellar function -- Gait and station -- The autonomic nervous system -- Peripheral neuroanatomy and focal neuropathies -- Neck and back pain -- Other musculoskeletal disorders -- The blood supply of the brain -- The ventricular system and the cerebrospinal fluid -- The examination in coma -- Miscellaneous neurologic signs -- Diagnostic reasoning and neurologic differential diagnosis.
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    Motor strength and power -- Muscle tone -- Muscle volume and contour -- Abnormalities of movement -- -- Overview of the sensory system -- The exteroceptive sensations -- The proprioceptive sensations -- The interoceptive, or visceral, sensations -- Cerebral sensory functions -- Sensory localization -- -- Introduction to the reflexes -- The deep tendon or muscle stretch reflexes -- The superficial (cutaneous) reflexes -- Pathologic reflexes -- Postural and righting reflexes -- Associated movements -- -- Cerebellar function -- Gait and station -- -- The autonomic nervous system -- Peripheral neuroanatomy and focal neuropathies -- -- Neck and back pain -- Other musculoskeletal disorders -- -- The blood supply of the brain -- The ventricular system and the cerebrospinal fluid -- -- The examination in coma -- Miscellaneous neurologic signs -- -- Diagnostic reasoning and neurologic differential diagnosis. Overview of the nervous system -- The neurologic history -- The general physical examination -- General outline of the neurologic examination -- -- Gross and microscopic anatomy of the cerebral hemispheres -- Functions of the cerebral cortex and regional cerebral diagnosis -- The mental status examination -- Disorders of speech and language -- Agnosia, apraxia, and related disorders of higher cortical function -- -- An overview of brainstem and cranial nerve anatomy -- The olfactory nerve -- The optic nerve -- The ocular motor nerves -- The trigeminal nerve -- The facial nerve -- The acoustic (vestibulocochlear) nerve -- The glossopharyngeal and vagus nerves -- The spinal accessory nerve -- The hypoglossal nerve -- Brainstem and multiple cranial nerve syndromes -- -- Overview of the motor system -- The motor unit level -- The spinal cord level -- The corticospinal (pyramidal) level -- The extrapyramidal level
  • v. 1. A-C -- v. 2. D-Mec -- v. 3. Met-Nano -- v. 4. Near-R -- v. 5. S-XYZ.
  • 2014 ClinicalKey
    The revised DeLee & Drez's Orthopaedic Sports Medicine covers the surgical, medical, and rehabilitation/injury prevention topics related to athletic injuries and chronic conditions with coverage of both pediatric and aging athletes; important non-orthopaedic conditions involved in the management of the athlete; rapidly evolving techniques; and sports-related fractures. It aids in understanding rehabilitation and other therapeutic modalities in the context of return to play. It also covers arthroscopic techniques, including ACL reconstruction, allograft cartilage transplantation, rotator cuff repair, and complications in athletes, as well as injury prevention, nutrition, pharmacology, and psychology in sports.
  • Defining organs at risk is a crucial task for radiation oncologists when aiming to optimize the benefit of radiation therapy, with delivery of the maximum dose to the tumor volume while sparing healthy tissues. This book will prove an invaluable guide to the delineation of organs at risk of toxicity in patients undergoing radiotherapy. The first and second sections address the anatomy of organs at risk, discuss the pathophysiology of radiation-induced damage, and present dose constraints and methods for target volume delineation. The third section is devoted to the radiological anatomy of organs at risk as seen on typical radiotherapy planning CT scans, with a view to assisting the radiation oncologist to recognize and delineate these organs for each anatomical region head and neck, mediastinum, abdomen, and pelvis. The book is intended both for young radiation oncologists still in training and for their senior colleagues wishing to reduce intra-institutional variations in practice and thereby to standardize the definition of clinical target volumes.
  • Also available: Print – v. 1-2, 2010.
    Machine generated contents note: pt. I Principles of Assessment and Evaluation -- 1.Clinical Evaluation / Stephen F. Noil -- 2.The Physical Examination / Peter J. Moley -- 3.Assessment of Human Muscle Function / Jan Lexell -- 4.Electrodiagnostic Evaluation of the Peripheral Nervous System / Lawrence R. Robinson -- 5.Human Walking / Brian L. Bowyer -- 6.Imaging Techniques Relative to Rehabilitation / Angel Gomez -- 7.Diagnostic Ultrasound / Yi-Pin Chiang -- 8.Principles and Applications of Measurement Methods / Kathleen A. Hinderer -- 9.Functional Evaluation and Management of Self-care and Other Activities of Daily Living / Kristine L. Haerti -- 10.Disability Determination / Richard T. Katz -- 11.Applying the ICF in Rehabilitation Medicine / Alarcos Cieza -- 12.Systematically Assessing and Improving the Quality and Outcomes of Medical Rehabilitation Programs / Anne C. Hansen -- pt. II The Rehabilitation Team: Systems-Based Practice -- 13.Rehabilitation Team Function and Prescriptions, Referrals, and Order Writing / Amit Mehta -- 14.Psychological Aspects of Rehabilitation / Daniel E. Rohe -- 15.Speech, Language, Swallowing, and Auditory Rehabilitation / Jennifer Ryder -- 16.Sexuality and Disability / Andrei Krassioukov -- 17.Vocational Rehabilitation, Independent Living, and Consumerism / David Delambo -- 18.Community Participation and the Environment: Theoretical, Assessment and Clinical Implications / Daniel K. White -- 19.Systems-Based Practice of Physical Medicine and Rehabilitation / Jared Fleisher -- 20.Ethical Issues in Rehabilitation Medicine / Janet F. Haas -- 21.Interactions with the Medicolegal System / Steve R. Geiringer -- 22.International Aspects of the Practice of Rehabilitation Medicine / Chang-Il Park -- pt. III Major Conditions -- 23.Stroke Rehabilitation / Murray E. Brandstater -- 24.Traumatic Brain Injury / Tessa Hart -- 25.Multiple Sclerosis / Alexander Rae-Grant -- 26.Rehabilitation of Persons with Parkinson's Disease and Other Movement Disorders / Donna Moxley Scarborough -- 27.Rehabilitation of Spinal Cord Injury / Monifa Brooks -- 28.Adult Motor Neuron Disease / Gregory T. Carter -- 29.Peripheral Neuropathy / Maya Therattil -- 30.Myopathy / David D. Kilmer -- 31.Osteoarthritis / Sausheen Heslop -- 32.Disorders of the Cervical Spine / David I. Lipetz -- 33.Rehabilitation of Lumbar Spine Disorders: An Evidence-Based Clinical Practice Approach / Carlo Trevisan -- 34.Scoliosis and Other Spinal Deformities / Scott M. Paul -- 35.Upper Extremity Soft-Tissue Injuries / Kathleen Fink -- 36.Cumulative Trauma Disorders / Joanne Borg-Stein -- 37.Hand Disorders / Lynn H. Gerber -- 38.Foot Disorders / Lynn H. Gerber -- 39.The Prevention and Treatment of Osteoporosis / Gopi Kasturi -- 40.Rehabilitation of the Patient with Rheumatic Diseases / Lynn H. Gerber -- 41.Cardiac Rehabilitation / Matthew Bartels -- 42.Rehabilitation of the Patient with Respiratory Dysfunction / Eric Altschuler -- 43.Burn Rehabilitation / M. Catherine Spires -- 44.Rehabilitation for Patients with Cancer Diagnoses / Deborah J. Franklin -- 45.Vascular Diseases / Vincent J. Yacyshyn -- 46.Transplantation Medicine: A Rehabilitation Perspective / Michael Munin -- 47.Rehabilitation of the Individual with HIV / Steven M. Fine -- pt. IV Secondary Conditions and Complications -- 48.Physical Inactivity: Physiological and Functional Impairments and Their Treatment / Kathleen R. Bell -- 49.Treatment of the Patient with Chronic Pain / Maxim Eckmann -- 50.Spasticity and Muscle Overactivity as Components of the Upper Motor Neuron Syndrome / Neil N. Jasey, Jr. -- 51.Neurogenic Bladder and Bowel / Steven A. Steins -- 52.Pressure Ulcers / Kath Bogie -- pt. V Special Populations -- 53.Sports Medicine / Garrett S. Hyman -- 54.Physical Activity for People with Disabilities / Jennifer A. Gray-Stanley -- 55.Performing Arts Medicine / Katie Weatherhogg -- 56.Children with Disabilities / Michael Armento -- 57.Adults with Childhood-Onset Disabling Conditions / Dennis Matthews -- 58.Empowering Women with Disabilities to be Self-Determining in their Health Care / Cassing Hammond -- 59.Aging and Rehabilitation / Hilary C. Siebens -- 60.Primary Care for Persons with Disability / Amanda Harrington -- pt. VI Management Methods -- 61.Therapeutic Exercise / Daniel A. Judelson -- 62.Aquatic Rehabilitation / Andrew J. Cole -- 63.Therapeutic Physical Agents / G. David Baxter -- 64.Manipulation, Massage, and Traction / Gregory Thompson -- 65.Pharmacotherapy of Disability / Jiaxin J. Iran -- 66.The Pharmacology of Analgesic Agents / Antonio Hernandez -- 67.Injection Procedures / Maxim Eckmann -- 68.Spinal Injection Procedures / Evish Kamrava -- 69.Palliative Care Symptom Management / Andrea L. Cheville -- 70.Evolution of Biofeedback in Physical Medicine and Rehabilitation / He (Helen) Huang -- 71.Therapeutic Electrical Stimulation in Neurorehabilitation / John Chae -- 72.Functional Neuromuscular Electrical Stimulation / John Chae -- 73.Assistive Technology / Cathy Bodine -- 74.Upper and Lower Extremity Prosthetics / Daniel Santa Maria -- 75.Upper Limb Orthotics / Heikki Uustal -- 76.Lower Extremity Orthotics, Shoes, and Gait Aids / Alberto Esquenazi -- 77.Spinal Orthotics / Eva Durand -- 78.Wheelchairs / Rosemarie Cooper -- 79.Complementary and Alternative Medicine / David Jung Seto -- pt. VII Scientific Advances -- 80.Evidence-Based Practice in Rehabilitation (Including Clinical Trials) / Alan M. Jette -- 81.Neural Repair and Plasticity / Steven C. Cramer -- 82.Regenerative Medicine: Implications in Rehabilitation / Fabrisia Ambrosio -- 83.Rehabilitation Robotics / N. Hogan.
  • "In the United States, approximately 14 million people have had cancer and more than 1.6 million new cases are diagnosed each year. However, more than a decade after the Institute of Medicine (IOM) first studied the quality of cancer care, the barriers to achieving excellent care for all cancer patients remain daunting. Care often is not patient-centered, many patients do not receive palliative care to manage their symptoms and side effects from treatment, and decisions about care often are not based on the latest scientific evidence. The cost of cancer care also is rising faster than many sectors of medicine--having increased to 125 billion in 2010 from 72 billion in 2004--and is projected to reach 173 billion by 2020. Rising costs are making cancer care less affordable for patients and their families and are creating disparities in patients' access to high-quality cancer care. There also are growing shortages of health professionals skilled in providing cancer care, and the number of adults age 65 and older--the group most susceptible to cancer--is expected to double by 2030, contributing to a 45 percent increase in the number of people developing cancer. The current care delivery system is poorly prepared to address the care needs of this population, which are complex due to altered physiology, functional and cognitive impairment, multiple coexisting diseases, increased side effects from treatment, and greater need for social support. Delivering High-Quality Cancer Care: Charting a New Course for a System in Crisis presents a conceptual framework for improving the quality of cancer care. This study proposes improvements to six interconnected components of care: (1) engaged patients; (2) an adequately staffed, trained, and coordinated workforce; (3) evidence-based care; (4) learning health care information technology (IT); (5) translation of evidence into clinical practice, quality measurement and performance improvement; and (6) accessible and affordable care. This report recommends changes across the board in these areas to improve the quality of care. Delivering High-Quality Cancer Care: Charting a New Course for a System in Crisis provides information for cancer care teams, patients and their families, researchers, quality metrics developers, and payers, as well as HHS, other federal agencies, and industry to reevaluate their current roles and responsibilities in cancer care and work together to develop a higher quality care delivery system. By working toward this shared goal, the cancer care community can improve the quality of life and outcomes for people facing a cancer diagnosis."--Publisher's description.
  • pt. 1. The effectiveness of controlled release and delivery systems -- pt. 2. Materials and techniques for controlled release and delivery of nutrients -- pt. 3. Delivery and controlled release of particular nutraceuticals -- pt. 4. Regulatory issues and future trends.
  • Print Material
  • Clinical investigations in primary care / de Souza, L.C. ... [et al.] -- The concept of mild cognitive impairment : relevance and limits in clinical practice / Michon, A. -- Pathological substrates of cognitive decline in Alzheimer's disease / Giannakopoulos, P. ... [et al.] -- Functional imaging in mild cognitive impairment and early Alzheimer's disease : is it pertinent? / Ibáñez, V.; Deiber, M.-P. -- Electrophysiological markers of rapid cognitive decline in mild cognitive impairment / Giannakopoulos, P. ... [et al.] -- The future : new methods of imaging exploration in Alzheimer's disease / Nordberg, A. -- Pharmacological interventions in primary care : hopes and illusions / Assal, F.; van der Meulen, M. -- Investigations in primary care / Poggesi, A.; Pantoni, L. -- The concept of vascular cognitive impairment / Erkinjuntti, T.; Gauthier, S. -- Defining the neuropathological background of vascular and mixed dementia and comparison with magnetic resonance imaging findings / Gold, G. -- Is it possible to treat vascular dementia? / Zekry, D. -- Dementia with Lewy bodies : clinical diagnosis and therapeutic approach / Gold, G. -- Significance of brain lesions in Parkinson disease dementia and Lewy body dementia / Jellinger, K.A. -- Delineating dementia with Lewy bodies : can magnetic resonance imaging help? / von Gunten, A.; Meuli, R. -- Pharmacotherapy of Parkinson disease dementia and Lewy body dementia / Gauthier, S. -- Clinical features and diagnosis of frontotemporal dementia / Kertesz, A. -- Neuropathological spectrum of frontal lobe dementias / Kövari, E. -- Frontotemporal dementia neuroimaging : a guide for clinicians / Seeley, W.W. -- Frontotemporal dementia : therapeutic interventions / Mendez, M.F.
  • This concise, pragmatic, pocket-sized book addresses neurological contributions to the diagnosis and management of dementia through a longitudinal examination of the work undertaken in a dedicated neurological dementia clinic. It covers the use of cognitive and non-cognitive screening instruments and their diagnostic utility and the use of other diagnostic investigations: neuroimaging, neurophysiology and neuropathology. The diagnostic mix is discussed in terms of both neuropsychological syndromes and neurological diagnoses, as is the use of conventional treatments for dementia and the impact of national directives (e.g. NICE, National Dementia Strategy) on day-to-day clinical practice. Dementia in Clinical Practice: A Neurological Perspective, Second Edition is an illustrated, practical resource for medical professionals involved in the assessment and management of dementia patients. It is of particular benefit to neurologists, psychiatrists, geriatricians, primary care practitioners and those working in the fields of neuropsychology, psychology, occupational therapy, speech and language therapy and nursing.
  • Referral patterns -- Congitive assessment -- Noncognitive assessment and combinations of scales -- Investigation -- Diagnosis -- Management.
  • Dementias 2008
    Also available: Print – 2008
  • Demographic yearbook 1946-
    United Nations
  • Print Material
  • Dendritic cells 2009
  • Also available: Print – 2001
  • The central role of dendritic cells in immunity / Jessica Chu and Russell D. Salter -- Dendritic cells in cancer: emergence of the discipline / Michael R. Shurin and Michael T. Lotze -- Part I. Alterations of the dendritic cell system in cancer -- Tumor-infiltrating dendritic cells: the pathologist's perspective / Dmitry W. Gutkin -- Functional defects of dendritic cells in cancer / Mikhail M. Dikov and Irina S. Chekneva -- General properties of dendritic cell populations in cancer / Benjamin J. Daniel, Duane P. Jeansonne, Suzanne R. Thibodeaux, and Tyler J. Curiel -- Elimination of dendritic cells in cancer ? Viktor Umansky and Dirk Schadendorf -- Part II. Mechanisms of dendritic cell dysfunction in cancer -- Tumor-derived factors responsible for dendritic cell dysfunction / Alberto Pinzon-Charry and J. Alejandro López -- Tumor-derived exosomes as dendritic cell modulators / Roberta Valenti ... [et al.] -- Signaling pathways mediating dendritic cell dysfunction in cancer / Jing Yang and Qing Yi -- A role for STAT3 in dendritic cell regulation by tumor-derived factors / Dmitry I. Gabrilovich -- Tumor-associated inflammation and impact of dendritic cell function / Zoltan Pos ... [et al.] -- Changes in dendritic cells in cancer and aging / Annabelle Grolleau-Julius and Raymond L. Yung -- Stress, immunity and dendritic cells in cancer / Rachel Kohman and Alexander W. Kusnecov -- Cancer therapy and dendritic cell immunomodulation / Galina V. Shurin, Neil Amina, and Michael R. Shurin -- Part III. Role of dendritic cells in tumor escape -- Role IDO in dendritic cell differentiation and function in cancer / Alexey Popov and Joachim L. Schultze -- Dendritic cells: from inducers of specific T-cell responses to promoters of angiogenesis / George Coukos and Fabian Benencia -- Protumorigenic function of dendritic cells / Anjli Kukreja -- Dendritic cell maturation versus polarization in tumor escape / Michael W. Lipscomb, Walter J. Storkus, and Amy K. Wesa -- Part IV. Dendritic cells in cancer: clinical aspects -- Trafficking of dendritic cells in the tumor environment / Zoya R. Yurkovetsky and Ghena N. Yurkovetsky -- Dendritic cells in tumor-draining lymph nodes / Alistair J. Cochran ... [et al.] -- Dendritic cell vaccines in cancer: obstacles to overcome / Ezra D. Mirvish, Rebecca G. Pomerantz, Louis D. Falo, and Larisa J. Geskin -- How best to generate dendritic cells from patients with cancer and how best to use them for immunotherapeutic purposes / Mark M. Aloysius, Richard A. Robins, and Oleg Eremin -- Genetically modified dendritic cells in cancer immunotherapy / Brian J. Morrison ... [et al] -- Dendritic cell tumors / Lourdes R. Ylagan -- Future directions in dendritic cell research in cancer / Madhav V. Dhodapkar.
  • Also available: Print – 2009
    "Since the second edition of Dengue haemorrhagic fever: diagnosis, treatment, prevention and control was published by the World Health Organization (WHO) in 1997, the magnitude of the dengue problem has increased dramatically and has extended geographically to many previously unaffected areas. It was then, and remains today, the most important arthropod-borne viral disease of humans. Activities undertaken by WHO regarding dengue are most recently guided at the global policy level by World Health Assembly resolution WHA55.17 (adopted by the Fifty-fifth World Health Assembly in 2002) and at the regional level by resolution CE140.R17 of the Pan American Sanitary Conference (2007), resolution WPR/RC59.R6 of the WHO Regional Committee for the Western Pacific (2008) and resolution SEA/RC61/R5 of the WHO Regional Committee for South-East Asia (2008). This new edition has been produced to make widely available to health practitioners, laboratory personnel, those involved in vector control and other public health officials, a concise source of information of worldwide relevance on dengue. The guidelines provide updated practical information on the clinical management and delivery of clinical services; vector management and delivery of vector control services; laboratory diagnosis and diagnostic tests; and surveillance, emergency preparedness and response. Looking ahead, some indications of new and promising avenues of research are also described. Additional and more detailed specific guidance on the various specialist areas related to dengue are available from other sources in WHO and elsewhere, some of which are cited in the references. The contributions of, and review by, many experts both within and outside WHO have facilitated the preparation of this publication through consultative and peer review processes. All contributors are gratefully acknowledged, a list of whom appears under "Acknowledgements". These guidelines are the result of collaboration between the WHO Department of Control Neglected Tropical Diseases, the WHO Department of Epidemic and Pandemic Alert and Response, and the Special Programme for Research and Training in Tropical Diseases. This publication is intended to contribute to prevention and control of the morbidity and mortality associated with dengue and to serve as an authoritative reference source for health workers and researchers. These guidelines are not intended to replace national guidelines but to assist in the development of national or regional guidelines. They are expected to remain valid for five years (until 2014), although developments in research could change their validity, since many aspects of the prevention and control of dengue are currently being investigated in a variety of studies. The guidelines contain the most up-to-date information at the time of writing. However, the results of studies are being published regularly and should be taken into account. To address this challenge, the guide is also available on the Internet and will be updated regularly by WHO." - p. v.
  • Dengue : transmission, diagnosis and surveillance / James Whitehorn & Jeremy Farrar -- Biomarkers for dengue : prospects and challenges / Sophie Yacoub, Annette Fox, Nguyen Van Kinh, Gavin Screaton & Heiman Wertheim -- Dengue diagnosis : commercially available kits and laboratory support / Monique da Rocha Queiroz Lima, Rita Maria Ribeiro Nogueira & Flávia Barreto dos Santos -- Lessons learned from dengue : focus on Taiwan / Tzong-Shiann Ho, Chiou-Feng Lin, Ching-Chuan Liu, Trai-Ming Yeh, Robert Anderson & Yee-Shin Lin -- Dengue and international travel / Silvia Odolini, Alberto Matteelli & Francesco Castelli -- Intraepidemic increases in dengue disease severity : applying lessons on surveillance & transmission / Scott B. Halstead -- Prospects for controlling dengue spread : vaccines and vector control / Monica A. McArthur, Marcelo B. Sztein & Robert Edelman -- Ask the experts : surveillance of global dengue distribution / Jane Messina, Oliver Brady, Simon Hay, Jeremy Farrar & James Whitehorn -- Multiple choice questions : answers.
  • Dengue virus 2010
    Also available: Print – 2010
    Prospective cohort studies of dengue viral transmission and severity of disease / Timothy P. Endy, In-Kyu Yoon, Mammen P. Mammen -- Control of dengue virus translation and replication / Suman M. Paranjape, Eva Harris -- Subversion of interferon by dengue virus / Jorge L. Munoz-Jordan -- Dengue virus virulence and transmission determinants / R. Rico-Hesse -- Systemic vascular leakage associated with dengue infections - the clinical perspective / Dinh D. Trung, Bridget Wills -- Markers of dengue disease severity / Anon Srikiatkhachorn, Sharone Green -- Cellular immunology of sequential dengue virus infection and its role in disease pathogenesis / Alan L. Rothman -- HLA and other gene associations with dengue disease severity / H.A.F. Stephens -- Vector dynamics and transmission of dengue virus: implications for dengue surveillance and prevention strategies / Thomas W. Scott, Amy C. Morrison -- Dengue vaccine candidates in development / Anna P. Durbin, Stephen S. Whitehead -- Targeted mutagenesis as a rational approach to dengue virus vaccine development / Joseph E. Blaney Jr., Anna Pl Durbin, Brian R. Murphy, Stephen S. Whitehead.
  • Print Material
    Describes why humans are able to deny reality and ignore their own inevitable deaths to the detriment of the entire species and what might be done to change this mindset.
  • Patient evaluation and risk assessment -- Cardiovascular disease -- Pulmonary disease -- Gastrointestinal disease -- Genitourinary disease -- Endocrine and metabolic disease -- Immunologic disease -- Hematologic and oncologic disease -- Neurologic, behavioral, and psychiatric disorders.
  • Dental evolution and dental morphology: Introduction / S.E. Bailey -- Patterns of molar variation in great apes and their implications for hominin taxonomy / V. Pilbrow -- Trends in postcanine occlusal morphology within the hominin clade : the case of Paranthropus / S.E. Bailey and B.A. Wood -- Maxillary molars cusp morphology of South African australopithecines / J. Moggi-Cecchi and S. Boccone -- Gran Dolina-TD6 and Sima de los Huesos dental samples : preliminary approach to some dental characters of interest for phylogenetic studies / M. Martinón-Torres ... [et al.] -- Neural network analysis by using the Self-Organizing Maps (SOMs) applied to human fossil dental morphology : a new methodology / F. Manni, R. Vargiu and A. Coppa -- Micro-computed tomography of primate molars : methodological aspects of three-dimensional data collection / A.J. Olejniczak, F.E. Grine and L.B. Martin -- HRXCT analysis of hominoid molars : a quantitative volumetric analysis and 3D reconstruction of coronal enamel and dentin / D.G. Gantt, J. Kappelman and R.A. Ketcham -- Dental microstructure and life history: Introduction / R. Macchiarelli and S.E. Bailey -- Inferring primate growth, development and life history from dental microstructure : the case of the extinct Malagasy lemur, Megaladapis / G.T. Schwartz, L.R. Godfrey and P. Mahoney -- Histological study of an upper incisor and molar of a bonobo (Pan paniscus) individual / F. Ramirez Rossi and R.S. Lacruz -- New perspectives on chimpanzee and human molar crown development / T.M. Smith ... [et al.] -- Portable confocal scanning optical microscopy of Australopithecus africanus enamel structure / T.G. Bromage ... [et al.] -- Imbricational enamel formation in Neandertals and recent modern humans / D. Guatelli-Steinberg ... [et al.] -- Dental development: Introduction / B.A. Wood -- Of mice and monkeys : quantitative genetic analyses of size variation along the dental arcade / L.J. Hlusko and M.C. Mahaney -- Quantifying variation in human dental development sequences : an evo-devo perspective / J. Braga and Y. Heuze -- Dental calcification stages of the permanent M1 and M2 in U.S. children of African-American and European-American ancestry born in the 1990s / J. Monge ... [et al.] -- A computerized model for reconstruction of dental ontogeny : a new tool for studying evolutionary trends in the dentition / P. Smith ... [et al.] -- Dentition and diet: Introduction / F.E. Grine -- An evaluation of changes in strontium/calcium ratios across the neonatal line in human deciduous teeth / L.T. Humphrey, M.C. Dean and T.E. Jeffries -- Dental topography and human evolution with comments on the diets of Australopithecus africanus and Paranthropus / P.S. Ungar -- Dental microwear and paleoanthropology : cautions and possibilities / M.F. Teaford -- Tooth wear and diversity in early hominid molars : a case study / L. Ulhaas, O. Kullmer and F. Schrenk -- 3-D interferometric microscopy applied to the study of buccal enamel microwear / F. Estebaranz ... [et al.].
  • Dental Evolution -- Tooth development -- Dental Pulp is a Connective Tissue -- Dental Pulp Stem Cells (DPSC) -- Isolation methods of DPSC -- Characterization of DPSC -- Reprogramming of DPSC to induced pluripotent stem cells (iPSC) -- Immunomodulatory effects of DPSC -- Dental Pulp is a Complex Adaptive System.
  • Dental radiology 2015
  • 1. The Principles of Dependability -- 2. System Safety Assessment -- 3. Fault Tree Analysis -- 4. Failure Modes and Effects Analysis -- 5. Machine Learning Methods with Applications to Diagnosis -- 6. Byzantine Medical Problems: Decision Making with Misleading, Imperfect Information -- 7. Process Driven Methods in Diagnosis and Treatment -- 8. Toyota Production System -- 9. Reliance Implementation Methods Applied to a Kaizen Project -- 10. Knowledge & Culture.
  • Adipose tissue is found in diverse depots throughout the human body. The diversity of physiological specialization of these fat depots is reflected in the diverse depot-specific alterations seen in lipodystrophies and links between specific patterns of fat distribution and susceptibility to diseases, including Type II Diabetes and coronary artery disease. Previous studies, although focused on only 2 major fat depots (omental and abdominal subcutaneous), have identified numerous differences in metabolic, endocrine and developmental programs. We carried out a more extensive and higher resolution investigation of the anatomic specialization of white adipose tissue, based on 59 samples collected from 7 anatomically diverse fat depots, from 56 individuals. Using DNA microarrays we measured relative abundance of ~25,000 distinct mRNAs in each adipose tissue sample and in adipocytes and stromal-vascular cells isolated from each sample, and compared their gene expression patterns with ~120 samples representing diverse non-adipose tissues. Adipocytes from different regions of the body displayed distinct gene expression profiles. Characteristic patterns of expression of HOX genes distinguished adipocyte samples by site of origin; these patterns were recapitulated when adipocyte precursors from each site were cultured and differentiated ex vivo, suggesting that these genes may have a role in programming and/or maintaining depot-specific differentiation of adipocytes. Expression in adipocytes of 300 genes with major roles in energy metabolism showed both depot-dependent and inter-individual variation. Some of the patterns suggested important differences among anatomic depots in metabolic roles. For example, a set of genes involved in lipid uptake and storage and hormone-regulated lipolysis were generally most highly expressed in breast, pericolonic and omental adipocytes whereas genes involved in glycogen metabolism and de novo fatty acid synthesis were generally most highly expressed in breast and abdominal subcutaneous adipocytes, suggesting that these depots play a role as glucose buffers. Dozens of genes known or predicted to encode secreted molecular signals were highly expressed in adipocytes compared to either adipose stromal-vascular cells or other organs; many of these were differentially expressed among adipocyte depots. Some of these genes appear to be good candidates for encoding novel adipokines. In summary, we found extensive variation among adipose depots, as well as inter-individual variation, in global gene expression. Differences in genes linked to development, metabolism and cell-cell communication suggest new hypotheses relevant to depot-specific and general aspects of adipocyte biology.
  • Antidepressant compounds : a critical review / S.W. Tang, D.M. Helmeste, B. Leonard -- The hypothalamic-pituitary-adrenal axis in depression / M. Julio-Pieper, T.G. Dinan -- Dysfunctional circadian rhythms and mood disorders : opportunities for novel therapeutic approaches / T.R. Norman -- The concept of depression as a dysfunction of the immune system / B.E. Leonard -- The role of polyunsaturated fatty acids in the pathology and treatment of depression / C. Song -- Overcoming antidepressant treatment resistance : focus on glutamate / J.W. Murrough, S.J. Mathew -- Neuroimaging and the pathophysiology and treatment of depression : recent advances and future needs / D.M. Cannon -- Animal models of depression : where are we going? / D.A. Slattery, J.F. Cryan -- Genetic models of depression and antidepressant response / I. Lucki -- The role of 5-HT2C receptors in the antidepressant response : a critical review / C.B.P. Martin ... [et al.] -- Chromatin-based treatments for affective disorders : insight or utopia / H.E. Covington III, O. Berton -- Neurotrophic factors and antidepressant action : recent advances / O.F. O'Leary, E. Castron -- Neurogenic basis of antidepressant action : recent advances / A. Tanti, C. Belzung -- The nature and treatment of therapy-resistant depression / S.H. Kennedy, S.J. Rizvi, P. Giacobbe -- Optimizing antidepressant management of depression : current status and future perspectives / T.L. Schwartz, S.M. Stahl.
  • Depression ranks as a leading mental health problem among Hispanic immigrants and their US-born children. And a wide array of issues - starting with the widespread stereotype of the "illegal immigrant" - makes the Latino experience of this condition differ from that of any other group. Depression in Latinos consolidates the conceptual, diagnostic, and clinical knowledge base on this salient topic, providing coverage from prevalence to prevention, from efficient screening to effective interventions. In this concise yet comprehensive volume, leading clinicians, researchers, and academics offer extensive research and clinical findings, literature reviews (e.g., an in-depth chapter on the Mexican American Prevalence and Services Survey), and insights gathered from first-hand experience in clinical practice. Perceptive information is offered on the most urgent and complex issues on depression in this diverse and dynamic population, including: (1) the impact language, culture, and societal factors have on depression and its diagnosis; (2) the most relevant assessment instruments; (3) how depression manifests among Latino children, youth, and seniors as well as in Latinas; (4) the relationship between depression and substance abuse; (5) the most effective evidence-based treatment methods; and (6) the efficacy of interventions for depression at the community level.
  • Dépressions 2009
  • The degradation of misfolded secretory proteins is ultimately mediated by the ubiquitin-proteasome system in the cytoplasm, therefore endoplasmic reticulum-associated degradation (ERAD) substrates must be dislocated across the ER membrane through a process driven by the AAA ATPase p97/VCP. Derlins recruit p97/VCP and have been proposed to be part of the dislocation machinery. Here we report that Derlins are inactive members of the rhomboid family of intramembrane proteases and bind p97/VCP through C-terminal SHP boxes. Human Derlin-1 harboring mutations within the rhomboid domain stabilized mutant [alpha]-1 antitrypsin (NHK) at the cytosolic face of the ER membrane without disrupting the p97/VCP interaction. We propose that substrate interaction and p97/VCP recruitment are separate functions that are essential for dislocation and can be assigned respectively to the rhomboid domain and the C terminus of Derlin-1. These data suggest that intramembrane proteolysis and protein dislocation share unexpected mechanistic features.
  • Also available: Print – 2014
  • Skin: Architecture and Function -- Skin Tissue Engineering -- Use of Novel Biomaterial Design and Stem Cell Therapy in Cutaneous Wound Healing -- In Vivo Visualisation of Skin Graft Revascularisation -- The Role of Elastin in Wound Healing and Dermal Substitute Design -- Surface Modi fi cation by Cold Gasplasma: A Method to Optimise the Vascularisation of Biomaterials -- Collagen Matrices with Enhanced Angiogenic and Regenerative Capabilities -- 3D Visualisation of Skin Substitutes -- Wound Coverage Technologies in Burn Care-Established and Novel Approaches -- Collagen Implants in Hernia Repair and Abdominal Wall Surgery -- The Use of Dermal Substitutes in Dermatosurgery -- The Use of Dermal Substitutes in Breast Reconstruction: An Overview -- Reconstruction of the Skin in Posttraumatic Wounds -- Subdermal Tissue Regeneration -- Bioengineering and Analysis of Oral Mucosa Models -- The Use of Dermal Substitutes in Burn Surgery: Acute Phase -- Burn Reconstruction.
  • An Overview of Cutaneous Lymphomas -- Vascular Tumors -- Histiocytic Proliferations -- ʺFibrohistiocyticʺ Proliferations -- Tumors of Fat, Nerve, and Smooth Muscle -- Cutaneous Metastases -- Further Reading.
  • Part I. Dermatologist as Clinician -- 1. "Excuse Me...": Unsolicited Dermatologic Opinions: Ethical, Moral, and Legal Issues / Lionel Bercovitch -- 2. "Give Me Enbrel(TM) or Give Me Death": Confronting the Limits of Autonomy / Lionel Bercovitch -- 3. Direct-to-Consumer Advertising of Prescription Medications: Misguided "Autonomy" in the Information Age / Lisa Pappas-Taffer and Alexander Miller -- 4. Autonomy, Isotretinoin and iPLEDGE: The Ethics of Burdensome Regulation and Use of Teratogenic Medication / Kenneth E. Bloom and Lionel Bercovitch -- 5. "Who Speaks for the Child?" Consent, Assent, and Confidentiality in Pediatric Dermatology / Kenneth E. Bloom and Lionel Bercovitch -- 6. Therapeutic Privilege: If, When, and How to Lie to Patients / Richard G. Fried and Clifford Perlis -- 7. Communicating with Patients About Adverse Medical Events: If, When, and How to Say "I'm Sorry" / Steven Shama, Lyn Duncan, and Lionel Bercovitch -- 8. The Computer Will See You Now: Ethics of Teledermatology / Jennifer L. Weinberg, Rachel H. Gormley, and Carrie L. Kovarik -- 9. Hospital Consultations: Embracing Professionalism Even When It Hurts / Lauren E. Krug and Stephen E. Helms -- 10. The Extender Is In: Delegating Ethically, Ethical and Professional Issues Relating to Physician Extenders in Dermatology / Steven Rosenberg and Clifford Perlis -- Part II. Dermatologist as Professional -- 11. Professional Boundaries: Safeguarding the Physician-Patient Relationship / Brandon H. Krupp -- 12. Taking Care of Uncle Bob's Rash: Should One Treat Family Members? / Sandra Osswald -- 13. Peering into the Gift Horse: Is It Ethical to Accept Gifts from Patients? / Lionel Bercovitch -- 14. The Dermatologist and Social Media: The Challenges of Friending and Tweeting / Jennifer A. Sbicca and Stanton K. Wesson -- 15. Respecting Differences: Dermatology in a Diverse Society / Vimal Prajapati and Benjamin Barankin -- 16. Dermatologists Within, Beyond and Struggling with Borders: The Global Dermatologist / Jennifer L. Weinberg -- 17. Feet of Clay: The Impaired Dermatologist / Brandon H. Krupp -- Part III. Dermatologist as Teacher and Trainee -- 18. The Mentor-Mentee Relationship: The Devil Is in the Details / Kimberly L. Merkel, John A. Cole, and Stanton K. Wesson -- 19. Tales from the Residency Interview Trail / Jennifer A. Sbicca and Alfred T. Lane -- 20. Ethics Education for Residents: Growing Pains and Learning Crises / Irèn Kossintseva and Benjamin Barankin -- 21. Teaching Ethics in Clinic: Keeping You Smart and Honest / Nely Z. Aldrich and Eliot N. Mostow -- Part IV. Dermatologist as Businessperson -- 22. Boutiques, Botox®, and Basal Cells: Can Dermatology Set Its Priorities? / Jeffrey J. Meffert and Maria Villegas -- 23. The Price Is Right: Office Dispensing and Product Pricing / Tivon Sidorsky -- 24. My Elixir, MD: Morphing a Medical Degree into a Skincare Brand / Julie Cantor -- 25. Marketing the Physician: From Antitrust to Distrust / Catherine L. Kowalewski and Jeffrey J. Meffert -- 26. What the Market Will Bear? Ethical and Professional Issues in Medical Fees / Carl Johnson and Lionel Bercovitch -- 27. Spa, MD: When Dermatology Meets Aromatherapy / Tivon Sidorsky and Lionel Bercovitch -- 28. Gatekeepers, Dermatologists, and Their Patients: Mixed Messages in Managed Care / Lindsey A. Brodell, Robert T. Brodell, and Brendan Minogue -- 29. Ethical Adventures in 21st Century Dermatopathology / Homer O. Wiland IV, Barry D. Kels, and Jane Grant-Kels -- 30. Defining the Gray Zone: Client Billing and Contractual Joint Ventures / Homer O. Wiland IV, Barry D. Kels, and Jane Grant-Kels -- 31. No Strings Attached? Managing Conflicts of Interest in Medicine / Noah D. Shannon and Clifford Perlis -- Part V Dermatologist as Scholar -- 32. Respecting Human Subjects: Responsibilities of the Clinical Investigator / Kenneth Katz and Samual Garner -- 33. Hope, Hype, and Genotype: Genetic Testing in Dermatological Diseases / Natasha Shur -- 34. Desperate Measures for Desperate Patients: Translational Research in Epidermolysis Bullosa / Alfred T. Lane -- 35. Reading Between the Lines: Can Peer Reviewers Be Expected to Detect Fraud? / Jason D. Gillum, Jeffrey D. Bernhard, and Robert P. Dellavalle -- 36. Hiding Behind the Curtain: Anonomyous Versus Open Peer Review / Andrea L. Suárez, Jeffrey D. Bernhard, and Robert P. Dellavalle -- 37. Ghost Busting in Dermatology Publications: Providing Byline Integrity / Andrea L. Suárez, Jeffrey D. Bernhard, and Robert P. Dellavalle -- 38. Telling the Same Tale Twice: Déjà vu and the Shades of Grey in Self-Plagiarism / Andrea L. Suárez, Jeffrey D. Bernhard, and Robert P. Dellavalle -- 39. Cutting Edge or Cutting Corners? Innovative Care / Jolion McGreevy and Clifford Perlis.
  • "Novel drug delivery technologies strive to bypass challenging biological layers to elicit desired pharmacological activity. The skin, one of our key defensive barriers, is imperfect, and may allow certain topically applied substances or toxins to pass. The dermatokinetics of a drug determines the efficacy of treatment of skin disorders. Presenting the first comprehensive reference on this important area of research, Dermatokinetics of Therapeutic Agents includes a general overview of the theoretical as well as practical aspects of dermatokinetics and addresses the impact of nature of a drug delivery system on the dermatokinetics of drugs. Chapters and illustrations cover the introductory aspects significance, methods, and models used in dermatokinetic studies of therapeutic agents.Topics include: Theoretical Models for Dermatokinetics of Therapeutic Agents; Drug Delivery Approaches to Modulate Dermatokinetics of Drugs; Conventional Methods of Cutaneous Drug Sampling; Cutaneous Microdialysis; Sampling Substrates by Skin Permeabilization; Spectroscopic Techniques in Dermatokinetics Studies; Regulatory Perspective of Dermatokinetic Studies"--Provided by publisher.
  • Drs. Richard Usatine, John Pfenninger, Daniel Stulberg, and Rebecca Small, provides you with the clear, step-by-step guidance you need to provide these options to your patients. Full-color photographs and drawings in combination with high-definition narrated videos clearly demonstrate key procedures, including skin biopsies, cryosurgery, electrosurgery, botulinum toxin injections, and more. Incorporate key dermatologic and cosmetic procedures into your practice with coverage of using dermoscopy to more accurately detect skin cancer, the latest information on lasers, botulinum toxin injections and dermal fillers, the diagnosis and treatment of benign and malignant lesions, and more. Master dermatologic and cosmetic procedures thanks to more than 40 narrated, high-definition videos on DVD, demonstrating skin biopsies, cryosurgery, electrosurgery, and excision of skin cancers, cysts, and lipomas. See how to perform each procedure clearly from detailed, full-color photographs and drawings and step-by-step instructions. Maximize the value of providing dermatologic and cosmetic procedures with guidance on combination treatments as well as coding and billing details. Enhance your practice with step-by-step guidance to perform virtually any skin procedure in the office setting.
  • Allergic contact dermatitis / M.D. Gober, A.A. Gaspari -- Immune privilege and the skin / T. Ito ... [et al.] -- Immunobiology of acute cytotoxic drug reactions / B.J. Nickoloff -- Psoriasis / F.O. Nestle -- Atopic dermatitis in 2008 / L.S. Chan -- Cutaneous Lupus erythematosus : molecular and cellular basis of clinical findings / A. Kuhn, R. Sontheimer -- Bullous pemphigoid and related subepidermal autoimmune blistering diseases / E.B. Olasz, K.B. Yancey -- Pemphigus vulgaris and its active disease mouse model / M. Amagai -- Pemphigus foliaceus / D. Dasher, D. Rubenstein, L. Diaz -- Autoimmunity to type VII collagen : Epidermolysis bullosa acquisita / J. Remington ... [et al.] -- Pathomechanisms of Lichen planus autoimmunity elicited by cross-reactive T cells / T. Shiohara ... [et al.] -- Autoimmune etiology of generalized vitiligo / I.C. Le Poole, R.M. Luiten -- The genetics of generalized vitiligo / R.A. Spritz -- Scleroderma / A.C. Gilliam -- Alopecia areata / L.E. King Jr., K.J. McElwee, J.P. Sundberg -- Dermatomyositis / M.S. Krathen, D. Fiorentino, V.P. Werth -- Novel mechanism for therapeutic action of IVIg in autoimmune blistering dermatoses / D. Michael, S.A. Grando -- Skin involvement in systemic autoimmune diseases / S. Rashtak, M.R. Pittelkowo -- Therapeutics and immune-mediated skin disease / K.B. Gordon, R. Satoskar.
  • Dermatologic surgery 2009
    Also available: Print – 2009
    1, Surgical anatomy of the head and neck -- 2, Antisepsis -- 3, Local anesthetics -- 4. Surgical instruments -- 5. Preoperative evaluation of the dermatologic surgery patient -- 6. Cutaneous wound healing -- 7. Electrosurgery -- 8. Cryosurgery -- 9. Biopsy techniques -- 10. Basic excisional surgery -- 11. Suture techniques -- 12. Suture materials -- 13. Flaps -- 14. Skin grafts -- 15. Nail surgery -- 16. Mohs micrographic surgery -- 17. Surgical complications -- 18. Sclerotherapy of varicose and telangiectatic leg veins -- 19. Lasers: physics and medical indications -- 20. Photodynamic therapy.
  • This book is a comprehensive introduction to ultrasonography of the skin, nails, and scalp as it relates to the assessment and diagnosis of dermatologic diseases. It provides a concise understanding of the diagnosis of dermatologic conditions through extensive high-resolution gray scale and color Doppler ultrasound images and presents classical correlations of clinical dermatologic lesions with sonographic and histologic findings.
  • Life span and life course approaches to dermatological disease / Ryff, C.D. -- Key concepts in the life course approach in medicine : allostatic load and cumulative life course impairment / Offidani, E.; Tomba, E.; Linder, M.D. -- Mathematical modeling in life course research / Barban, N.; Linder, M.D. -- Life course impairment and quality of life over time / Sampogna, F. -- Concept of major life-changing decisions in life course research / Bhatti, Z.U.; Salek, S.; Finlay, A.Y. -- Setting up a life course questionnaire / Sampogna, F. -- Cumulative life course impairment in chronic wounds / Augustin, M. -- Cumulative life course impairment : evidence for psoriasis / Mattei, P.L.; Corey, K.C.; Kimball, A.B. -- Cumulative life impairment by epidermolysis bullosa / Fine, J.-D. -- Cumulative life course impairment in vitiligo / Krüger, C.; Schallreuter, K.U. -- Cumulative life course impairment in melanoma and nonmelanoma skin cancer / Piaserico, S. -- Cumulative life course impairment : identifying patients at risk / Augustin, M. -- Cumulative life course impairment in dermatological diseases other than psoriasis : an overview / Ibler, K.S.; Jemec, G.B.E. -- Cumulative life course impairment across cultures and medical systems / Lima, X.T. -- Patients' narratives / Foulkes, A.C.; Warren, R.B.
  • Genodermatoses / Erin L. Reese -- Metabolic disorders / Davida A. Kornreich -- Hepatitis viruses / Ivy I. Norris and Cindy England Owen -- Human immunodeficiency virus / Caroline Y. Winslow and Francisco A. Kerdel -- Rheumatologic conditions / Kseniya Golubets, Dan Ilkovitch, and Lisa M. Grandinetti -- Xerosis / Connie M. Wu, Annie M. Wu, Jenna Lester, and Leslie Robinson-Bostom -- Pruritus in chronic kidney disease / Ehsan Azimi, Ethan A. Lerner, and Sarina B. Elmariah -- Dyschromias in renal disease / Mwatsveruka N. Munhutu and Rebat M. Halder -- Calcinosis cutis / Mitalee P. Christman and Daniela Kroshinsky -- Calciphylaxis / Julio C. Sartori-Valinotti and Mark Davis -- Acquired perforating disorders / Mieke L.F. Flour and Dirk R.J. Kuypers -- Nephrogenic systemic fibrosis / Avery LaChance, Ali K. Abu-Alfa, and Shawn E. Cowper -- Blistering disorders (Porphyria cutanea tarda and Pseudoporphyria) / Christine A. DeWitt, Kara M. Trapp, and Melissa A. Muszynski -- Nail diseases among renal patients / Avner Shemer, Nicole Sakka, and C. Ralph Daniel III -- Alopecias / Kimberly Scott Salkey -- Uremic frost / Kristie Lynn Slivka Delaney, Edgar V. Lerma, and Julia R. Nunley -- Infections in the kidney transplant recipient / James D. Russell and Calvin O. McCall -- Cutaneous malignancies / Melina B. Chu, Brandon T. Beal, and Ian A. Maher -- Miscellaneous drug related adverse effects / Punam H. Patel and Krista L. Donohoe -- Drug dosing in patients with chronic kidney disease and dermatological diseases / Ali J. Olyaei and Edgar V. Lerma.
  • Also available: Print – 2009
    1. Lupus erythematosus / Christopher B. Hansen, Jeffrey P. Callen -- 2. Dermatomyositis / Ruth Ann Vleugels, Jeffrey P. Callen -- 3. Scleroderma, Raynaud's phenomenon, and related conditions / Susannah E. McClain ... [et al.] -- 4. Vasculitis / Jeffrey P. Zwerner, Jeffrey P. Callen, David F. Fiorentino -- 5. Miscellaneous disorders with prominent features involving the skin and the joints / Brad A. Yentzer ... [et al.] -- 6. Urticaria / Andrew D. Lee, Joseph L. Jorizzo -- 7. Erythema multiforme, Stevens-Johnson syndrome, and toxic epidermal necrolysis / B. Asher Louden, Joseph L. Jorizzo -- 8. Erythema nodosum and other panniculitides / Manisha J. Patel, Joseph L. Jorizzo, Jeffrey P. Callen -- 9. Pruritus / Gil Yosipovitch -- 10. Erythroderma / Aaron M. Loyd, Joseph L. Jorizzo -- 11. Purpura / Warren W. Piette -- 12. Bullous diseases / Anneli R. Bowen, John J. Zone -- 13. Skin signs of internal malignancy / Edward W. Cowen, Jeffrey P. Callen -- 14. Metastatic disease / Warren W. Piette -- 15. Cutaneous manifestations of leukemias, myelodysplasti and myeloproliferative syndromes, and systemic lymphomas / Warren W. Piette -- 16. Dysproteinemias, plasma cell disorders, and amyloidosis / Warren W. Piette -- 17. Cutaneous manifestations of macrophage/dendritic cell proliferative disorders (histiocytoses) / Warren W. Piette -- 18. Vascular neoplasms / Julie V. Schaffer, Jean L. Bolognia -- 19. Primary cutaneous T-cell and B-cell lymphomas / Gary S. Wood, Warren W. Piette -- 20. Diabetes mellitus / Mohammad Reza Namazi, Gil Yosipovitch -- 21. Thyroid and the skin / Warren R. Heymann, Ted Rosen, Joseph L. Jorizzo -- 22. Lipids / Sarah L. Taylor, Kenneth E. Greer, Joseph L. Jorizzo -- 23. Adrenal, androgen-related, and pituitary disorders / Drew W. Miller, Steven R. Feldman, Joseph L. Jorizzo -- 24. Porphyrias / Julia R. Nunley, Marc E. Grossman, Warfen W. Piette -- 25. Cutaneous diseases associated with gastrointestinal abnormalities / Mark D. Herron, John J. Zone -- 26. Cutaneous hepatology / J. Mark Jackson, Jeffrey P. Callen, Kenneth E. Greer -- 27. Pancreatic disease / Daniel J. Pearce, Kenneth E. Greer, Joseph L. Jorizzo -- 28. Cutaneous manifestations of systemic viral, bacterial, and fungal infections and protozoan disease / Christina Haverstock ... [et al.] -- 29. Acquired immunodeficiency syndrome and sexually transmitted infections / Jean L. Bolognia -- 30. Sarcoidosis / Joseph C. English III, Jeffrey P. Callen -- 31. Cardiovascular diseases and the skin / Kathryn Schwarzenberger, Jeffrey P. Callen -- 32. Renal disease and the skin / Cheryl L. Lonergan, Thomas G. Cropley -- 33. Manifestations in transplant recipients / Dennis L. Cooper, Jean L. Bolgnia -- 34. Neurocutaneous disease / Clive M. Liu, John J. Zone -- 35. Pregancy / Lisa M. Cohen, George Kroumpouzos -- 36. Mast cell disease / Michael D. Tharp -- 37. Hair disorders in systemic disease / Raechele C. Gathers, Amy J. McMichael -- 38. Nail signs of systemic disease / Christopher B. Yelverton, Joseph L. Jorizzo -- 39. Oral mucous membranes and systemic disease / Charles Camisa, Jeffrey P. Callen -- 40. Leg ulcerations / Mark D.P. Davis -- 41. Cutaneous drug eruptions / Susan Burgin, Stephen E. Wolverton, Jeffrey P. Callen -- 42. Systemic therapy for cutaneous disease / Stephen E. Wolverton, Jeffrey P. Callen.
  • Print Material
    Contents. - pt. 1. A study of health manpower resources, 1963-1970.
  • Dermatology 2006
    Thieme Book
    Anogenital diseases -- Phlebology -- Occupational dermatoses -- Skin diseases in different age groups -- Psychodermatology -- Topical therapy -- Systemic therapy -- Radiation therapy -- Therapy during pregnancy and nursing -- Operative dermatology -- Wound healing -- Dermatologic emergencies. Introduction to skin biology -- Dermatologic diagnosis -- Other diagnostic methods -- Viral diseases -- Bacterial diseases -- Fungal diseases -- Other infectious diseases -- Sexually transmitted diseases -- HIV infection and AIDS -- Allergic diseases -- Drug reactions -- Dermatitis -- Collagen vascular disorders -- Autoimmune bullous diseases -- Purpura and vasculitis -- Papulosquamous disorders -- Granulomatous and necrobiotic disorders -- Dermatoses caused by physical and chemical agents -- Metabolic diseases -- Pruritus and prurigo -- Genodermatoses -- Disorders of pigmentation -- Melanocytic tumors -- Cysts and epidermal tumors -- Adnexal tumors -- Soft tissue tumors -- Other cutaneous tumors -- Cutaneous lymphomas and leukemia -- Paraneoplastic disorders -- Diseases of the lips and oral mucosa -- Diseases of the hairs and scalp -- Diseases of the nails -- Disorders of sweat glands -- Diseases of sebaceous glands -- Diseases of subcutaneous fat --
  • Basic Science and Immunology -- Pediatric Dermatology -- General Dermatology -- Infectious Diseases -- Benign and Malignant Tumors -- Dermatologic Surgery -- Pharmacology and Drug Reactions -- Pathology -- Dermoscopy and Electron Microscopy -- Life After Boards -- High Yield Facts and Buzz Words.
  • Machine generated contents note: Basic principles -- Microanatomy of the skin -- Derivatives of the skin -- Physiology of the skin -- Biochemistry of the skin -- Immunology of the skin -- Molecular genetics and the skin -- Terminology of skin lesions -- Taking a history -- Examining the skin -- Practical clinic procedures -- Basics of medical therapy -- Epidemiology of skin disease -- Body image, the psyche and the skin -- Diseases -- Eruptions -- Psoriasis -- epidemiology, pathophysiology and presentation -- Psoriasis -- management and complications -- Psoriasis -- biologics -- Eczema -- basic principles/contact dermatitis -- Eczema -- atopic eczema -- Eczema -- other forms -- Lichenoid eruptions -- Papulosquamous eruptions -- Erythroderma -- Photodermatology -- Infections -- Bacterial infection -- staphylococcal and streptococcal -- Other bacterial infections -- Viral infections -- warts and other viral infections -- Viral infections -- herpes simplex and herpes zoster
  • Print Material
  • This atlas, containing more than 300 color photos, focuses on those dermatologic conditions that are most common in ethnic skin or skin of color. It includes succinct explanations of each disease process, describes clinical findings, and presents key information on diagnosis and treatment. Individual chapters are devoted to pigmentary disorders, follicular disorders, hair and scalp disorders, eczemas, papulosquamous disorders, granulomatous disorders, connective tissue diseases, infectious diseases, scarring disorders, cutaneous neoplasms, photodermatoses and drug eruptions. The fact that this atlas covers skin disorders that affect patients of all ethnic backgrounds ensures that it will be of worldwide relevance. It will serve as a valuable reference for dermatologists and a range of other health care providers.
  • Dermatology essentials 2014
    Dermatology Essentials, edited by world authorities Drs. Jean L. Bolognia, Julie V. Schaffer, Karynne O. Duncan, and Christine J. Ko, provides the quick answers you need on every important aspect of dermatology and guidance on their application in your day-to-day practice. Derived from the renowned authoritative reference work Dermatology, 3rd Edition, this on-the-go reference distills the essential information needed to quickly diagnose and manage a wide range of dermatologic disorders-without the need for any additional resources. Review or refresh your knowledge of the fundamentals and diagnostic approaches of skin disease with unique introductory chapters providing the basic principles of dermatology, bedside diagnostics, and clinical approach to a fever and rash - extremely helpful for the beginner. Visualize more of the conditions you see in practice with over 1,500 clinical images, illustrations, and schematics. Avoid diagnostic pitfalls using practical tables, intuitive artworks, and logical algorithms. Find answers fast with a highly user-friendly, "easy-in-easy-out" format and a wealth of tables and schematics for instant visual comprehension. Expedite decision making with easily recognizable DDx and Rx sections to provide rapid direct reference to the expert guidance and treatment recommendations. Downloadable worksheets are also available. Make the most of electronic functionality with access to the complete contents online and in various ebook formats - making it easy to teach impromptu on a tablet in the clinic, or conduct more formal lecturing.
  • Skin: structure and function -- Immune system of the skin -- Diagnosis of skin disease -- Bacterial infections -- Superficial fungal infections -- Viral infections -- Parasitic infestations and diseases caused by arthropods -- Eczema -- Keratinizing and papulosquamous disorders -- Diseases of connective tissue -- Bullous disorders: autoimmune and childhood bullous dermatoses -- Vasculitis, common erythemas, and lymphatic disorders -- Exanthems and hypersensitivity syndromes -- Urticaria -- Pruritus -- Leg ulcers -- Disorders of pigmentation Disorders of ultraviolet radiation and injuries due to cold -- Diseases of the sebaceous, sweat, and apocrine glands -- Hair disorders -- Nail disorders -- Diseases of the subcutaneous tissue -- Tumors of the skin -- Naevi and hereditary diseases of the skin -- Skin and malnutrition -- Skin and systemic disease -- Skin and the psyche -- Erythroderma -- Ages of man and their dermatoses -- Diseases of the oral cavity -- Diseases of the external genitalia -- Miscellaneous disorders -- Drug reactions -- Management of skin diseases.
  • Print Material
  • Dermatology. 2nd ed. v. 1-2, 2008.
    Print Material
  • Dermatology. 3rd ed. 2012
    "Dermatology, edited by world authorities Jean L. Bolognia, MD, Joseph L. Jorizzo, MD, and Julie V. Schaffer, MD, is an all-encompassing medical reference book that puts the latest practices in dermatologic diagnosis and treatment at your fingertips. It delivers more comprehensive coverage of basic science, clinical practice, pediatric dermatology, and dermatologic surgery than you'll find in any other source. Whether you're a resident or an experienced practitioner, you'll have the in-depth, expert, up-to-the-minute answers you need to overcome any challenge you face in practice."--Publisher's website.
  • Print Material
  • Specific history -- Dermatologic physical examination -- Indicated supporting diagnostic data -- Therapy -- Molluscum contagiosum (dimple warts) -- Verruca vulgaris (common warts) -- Seborrheic dermatitis (dandruff) -- Pityriasis rosea -- Psoriasis vulgaris -- Lichen planus -- Miliaria rubra (prickly heat) -- Scabies -- Erythrasma -- Tinea (superficial fungi, dermatophytosis, ringworm) -- Urticaria (urticaria simplex, common hives) -- Fixed drug eruption -- Erysipelas/cellulitis -- Erythema multiforme -- Lupus erythematosus -- Toxicodendron dermatitis (poison oak, poison ivy, poison sumac; also known as Rhus dermatitis) -- Atopic dermatitis (atopic eczema, disseminated neurodermatitis -- Besnier's prurigo) -- Asteatotic eczema (xerosis, xerotic eczema, eczema craquelé, eczema cannalé, eczema hiemalis, winter itch) -- Senile purpura (Bateman's purpura) -- Striae distensae (striae atrophicans, striae gravidarum, stretch marks) -- Seborrheic keratosis (old age spots, liver spots) -- Ephelides (freckles) -- Lentigines -- Melanocytic nevi -- Malignant melanoma -- Actinic keratosis (solar keratosis) -- Keratoacanthoma (molluscum sebaceum) -- Common skin cancers -- Impetigo (impetigo contagiosa) -- Herpes simplex recidivans (herpes labialis, cold sores, fever blisters Herpes genitalis) -- Herpes zoster (shingles) -- Acne vulgaris (acne, zits) -- Rosacea (acne rosasea).
  • Papulosquamous Diseases / Herbert B. Allen -- Vesiculobullous Disorders (Including Dermatitis/Eczema) / Herbert B. Allen -- Infectious Diseases / Herbert B. Allen -- Hypersensitivity Disorders / Herbert B. Allen -- Genetic Diseases / Herbert B. Allen -- Dermatology in Systemic Disease / Herbert B. Allen -- Tumors / Herbert B. Allen -- Miscellaneous Disorders / Herbert B. Allen.
  • Dermatopathologie 2010
  • Dermatopathology 2011
    Part of the High-Yield Pathology Series, this title is designed to help you review the key pathologic features of skin disease, recognize the classic look of each disease, and quickly confirm your diagnosis. Its templated format, excellent color photographs, concise bulleted text, and authoritative content, will help you accurately identify more than 400 skin conditions. Find information quickly and easily with a templated, easy-to-reference format. Confirm your diagnoses with excellent color photographs that demonstrate the classic appearance of each disease. Find the answers you need fast with concise bulleted text. Depend on authoritative information from leading experts in the field.
  • Dermatopathology 2006
    Also available: Print – 2006
    1. Requirements for a Good Diagnostic Result, p. 1-3 -- 2. The Dermal Blood Vasculature, p. 4-8 -- 3. The Dermal Lymphatic Vasculature, p. 9-11 -- 4. The Immune Response, p. 12-20 -- 5. Cell and Vascular Response to Infection and Injury, p. 1-30 -- 6. Cell Death in the Living Body, p. 31-34 -- 7. Vasculitis, p. 35-64 -- 8. Skin Lesions due to Abnormalities in Blood Components, p. 65-74 -- 9. Arteriosclerosis in the Skin, p. 75-77 -- 10. Thromboangiitis Obliterans, p. 78-79 -- 11. Angiotropic Lymphoma, p. 80-82 -- 12. Infections Caused by Common Pyogenic Bacteria, p. 83-85 -- 13. Common Fungal Infections, p. 86-99 -- 14. Demodicidosis, p. 100-101 -- 15. Infections Caused by Mycobacterium Tuberculosis, M. Bovis, and Atypical Mycobacteria, p. 102-109 -- 16. Leprosy, p. 110-113 -- 17. Syphilis, p. 114-121-- 18. Lyme Borreliosis, p. 122-133 -- 19. Leishmaniasis, p. 134-135 -- 20. Herpes Simplex, Herpes Zoster/Varicella, and Cytomegalovirus Infections, p. 136-146 -- 21. Langerhans Cell Histiocytosis in Skin and Mucous Membranes, p. 147-154 -- 22. Dermatitis (Eczema), p. 155-162 -- 23. Psoriasis, p. 163-169 -- 24. Lichen Planus and Lichen Nitidus, p. 170-175 -- 25. Autoimmune Vesicular, Bullous, and Pustular Dermatoses, p. 176-198 -- 26. Recurrent Vesicular Eruptions, p. 199-209 -- 27. Profiles of the Epidermal/Dermal Area in some Vesicular/Bullous Dermatoses, p. 210-213 -- 28. Skin Lesions Due to Drugs, p. 214-230 -- 29. Artifacts, p. 231-244.
  • Elements of Cutaneous Embryology, Anatomy, and Biochemistry -- Classification of Cutaneous Lesions -- Hereditary Lesions -- Malformative Lesions -- Inflammatory Cutaneous Lesions -- Proliferative Cutaneous Lesions -- Miscellaneous Cutaneous Lesions.
  • With significant progress as new techniques to evaluate the pathology of the skin, this book satisfies the need to provide practical clinical information and concise criteria for pathologic diagnosis for pathologists and dermatologists looking for an up-to-date resource. This superb visual reference provides detailed instruction of the experience of both diagnostic pathology and clinical dermatology. Dermatopathology: Clinicopathological Correlations is a comprehensive but concise visual reference that contains specific features on the various clinical findings and histologic findings of skin diseases. It emphasizes criteria for diagnosis to help the trainee pathologist or dermatologist decipher the most important features and make clinical decisions quickly and effectively.
  • Print Material
  • New to this edition: Recognize the presentation of most major dermatopathology lesions through abundant high-resolution histopathology examples, with labels and pointers highlighting key aspects of each slide and providing additional clarity. Including 26 lectures by Dr. Elston, clinical and dermatopathology image atlases, and a virtual slide library. Easily focus on the most important "takeaways" and "must-knows" for each topic through the use of color key points, differential diagnosis, and pearls.
  • Inflammatory disease of the dermis and epidermis / Maxwell A. Fung -- Panniculitis / Maxwell A. Fung -- Infectious diseases of the skin / Helen M. Chen, Anca G. Prundeanu Croitoru, Stefanie Hu, Hideko Kamino, Marcia Ramos-e-Silva, Klaus J. Busam -- Cutaneous vasculitis / Rami N. Al-Rohil, J. Andrew Carlson -- Blistering skin diseases / Jacqueline M. Junkins-Hopkins, Klaus J. Busam -- Mucinoses, deposition disorders, and connective tissue alterations / Franco Rongioletti, Jacqueline Granese, Jacqueline Junkins-Hopkins, Luis Requena -- Non-neoplastic disorders of pigmentation / Ravi Ubriani, Loren E. Clarke, Michael E. Ming -- Non-neoplastic disorders of hair / Klaus Sellheyer, Wilma F. Bergfeld -- Cysts and sinuses / Douglas R. Fullen -- Tumors of the epidermis / Angela J. Wyatt, Klaus J. Busam -- Adnexal tumors / Victor G. Prieto, Christopher R. Shea, Julide Tok Celebi, Klaus J. Busam -- Melanocytic proliferations / Klaus J. Busam -- Soft tissue tumors and tumor-like reactions / Darya Buehler, Steven D. Billings -- Hematopoietic neoplasms / Jacqueline M. Junkins-Hopkins, Patricia L. Myskowski, Melissa P. Pulitzer -- Histiocytic proliferative disorders / Bijal Amin, Melissa P. Pulitzer, Klaus J. Busam -- Cutaneous neuroendocrine (Merkel cell) carcinoma / Bijal Amin, Klaus J. Busam -- Cutaneous metastases / Richard A. Scolyer, John F. Thompson, Annabelle Mahar, Rajmohan Murali -- Neoplastic and non-neoplastic disorders of the nail apparatus / Beth S. Ruben -- Neoplastic and non-neoplastic disorders of the conjunctiva and eyelid / Jasmine Francis, Klaus J. Busam, Brian Marr -- Evaluations of sections from Mohs surgery / Kishwer S. Nehal, Marie Tudisco, Klaus J. Busam.
  • Also available: Print – 2010
    1. Inflammatory diseases of the dermis and epidermis / Maxwell A. Fung -- 2. Panniculitis / Neil Scott McNutt, Maxwell A. Fung -- 3. Infectious diseases of the skin / Anca G. Prundeanu Croitoru ... [et al.] -- 4. Cutaneous vasculitis / J. Andrew Carlson -- 5. Blistering skin diseases / Jacqueline M. Junkins-Hopkins, Klaus J. Busam -- 6. Deposition disorders and miscellaneous alterations of dermal connective tissue / Franco Rongioletti, Jacqueline Granese, Jacqueline M. Junkins-Hopkins -- 7. Non-neoplastic disorders of pigmentation / Ravi Ubriani, Loren E. Clarke, Michael E. Ming -- 8. Non-neoplastic disorders of hair / Klaus Sellheyer, Wilma F. Bergfeld -- 9. Cysts and sinuses / Douglas R. Fullen -- 10. Tumors of the epidermis / Angela J. Wyatt, Klaus J. Busam -- 11. Adnexal tumors / Victor G. Prieto ... [et al.] -- 12. Melanocytic proliferations / Klaus J. Busam -- 13. Soft tissue tumors and tumor-like reactions / Steven D. Billings, John R. Goldblum -- 14. Hematopoietic neoplasms / Jacqueline M. Junkins-Hopkins, Patricia L. Myskowski, Klaus J. Busam -- 15. Histiocytic proliferative disorders / Bijal Amin, Melissa Pulitzer -- 16. Cutaneous nueroendocrine (Merkel cell) carcinoma / Bijal Amin, Klaus J. Busam -- 17. Cutaneous metastases / Richard A. Scolyer, Rajmohan Murali, John F. Thompson.
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  • Drs. Peter Soyer, Giuseppe Argenziano, Rainer Hofmann-Wellenhof, and Iris Zalaudek explain all aspects of performing dermoscopy and interpreting results. With approximately 50% new clinical and dermoscopic images, valuable pearls and checklists, and you'll have everything you need to diagnose earlier and more accurately. Diagnose more accurately using the expanded section on testing tools for extra guidance on difficult cases. Gain a better visual understanding with approximately 50% new clinical and dermoscopic images that depict the appearance of benign and malignant lesions and feature arrows and labels to highlight important manifestations. Get better diagnostic results for less by learning how to successfully perform dermoscopy with this portable, to-the-point resource.
  • Also available: Print – 5. éd., 1877.
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  • Design of bioavailability studies -- Statistical inferences for effects from a standard 2x2 crossover design -- Statistical methods for average bioequivalence -- Power and sample size determination -- Transformation and analysis of individual subject ratios -- Assessment of inter- and intra-subject variabilities -- Assumptions of outlier detection for average bioequivalence -- Optimal crossover designs for two formulations for average bioequivalence -- Assessment of bioequivalence for more than two formulations -- Population and individual bioequivalence -- Statistical procedures for assessment of population and individual bioequivalence -- Assessment of bioequivalence for drugs with negligible plasma levels -- In vitro bioequivalence testing -- In vitro dissolution profiles comparison -- Meta-analysis for bioequivalence review -- Population pharmacokinetics -- Other pharmacokinetic studies -- Review of regulatory guidances on bioequivalence -- Frequently asked questions and future challenges.
  • Overview of time-to-event endpoint methodology / Karl E. Peace -- Design (and monitoring) of clinical trials with time-to-event endpoints / Michael W. Sill and Larry Rubinstein -- Overview of time-to-event parametric methods / Karl E. Peace and Kao-Tai Tsai -- Overview of semiparametric inferential methods for time-to-event endpoints / Jianween Cai and Donglin Zeng -- Overview of inferential methods for categorical time-to-event data / Eric V. Slud -- Overview of Bayesian inferential methods including time-to-event endpoints / Laura H. Gunn -- An efficient alternative to the Cox model for small time-to-event trials / Devan V. Mehrotra and Arthur J. Roth -- Estimation and testing for change in hazard for time-to-event endpoints / Rafia Bhore and Mohammad Huque -- Overview of descriptive and graphical methods for time-to-event data / Michael O'Connell and Bob Treder -- Design and analysis of analgesic trials / Akiko Okamoto, Julia Wang, and Surya Mohanty -- Design and analysis of analgesic trials with paired time-to-event endpoints / Zhu Wang and Hon Keung Tony Ng -- Time-to-event endpoint methods in antibiotic trials / Karl E. Peace -- Design and analysis of cardiovascular prevention trials / Michelle McNabb and Andreas Sashegyi -- Design and analysis of antiviral trials / Anthony C. Segreti and Lynn P. Dix -- Cure rate models with applications to melanoma and prostate cancer data / Ming-Hui Chen and Sungduk Kim -- Parametric likelihoods for multiple nonfatal competing risks and death, with application to cancer data / Peter F. Thall and Xuemei Wang -- Design, summarization, analysis, and interpretation of cancer prevention trials / Matthew C. Somerville, Jennifer B. Shannon, and Timothy H. Wilson -- LASSO method in variable selection for right-censored time-to-event data with application to astrocytoma brain tumor and chronic myelogonous leukemia / Lili Yu and Dennis Pearl -- Selecting optimal treatments based on predictive factors / Eric C. Polley and Mark J. van der Laan -- Application of time-to-event methods in the assessment of safety in clinical trials / Kelly L. Moore and Mark J. van der Laan -- Design and analysis of chronic carcinogenicity studies of pharmaceuticals in rodents / Mohammad Atiar Rahman and Karl K. Lin -- Design and analysis of time-to-tumor response in animal studies : a Bayesian perspective / Steve Thomson and Karl K. Lin.
  • Using SAS, SPSS, and R, this book addresses design and analysis aspects in enough detail so that readers can apply statistical methods to their own longitudinal studies. This edition includes a new chapter on testing models that involve moderation and mediation, a new chapter on QALYs and QTWiST specific to clinical trials, and recent methodological developments for the analysis of trials with missing data. It also presents revised discussions of multiple comparisons procedures that focus on the integration of HRQoL outcomes with other study outcomes using gatekeeper strategies.
  • A balance between complexity and functional capabilities has been explored since the first years of multi-fingered robotic hands. In an age where DC motors are the de facto standard for actuation in robotics, the problem of needing to operate in a human-sized world puts severe constraints and limits on actuator size and placement in hands. While many successful examples of fully-actuated designs exist, these designs generally reflect the trade-offs and sacrifices imposed by such constraints. In that light, underactuation, employing fewer actuators than degrees of freedom, has gained attention as a method to achieve many of the functional capabilities of fully-actuated hands with fewer constraints on actuators and transmissions. Underactuated hands also have distinct advantages over fully actuated hands, especially when used on mobile robots, due to their reduced weight and control complexity, and the potential for increased robustness. However there is typically a trade-off in terms of reduced controllability or manipulability when handling grasped objects. When designing underactuated hands, extra care must be taken during the design process to ensure that such hands will grasp a wide range of object sizes and shapes robustly, particularly when friction is low and uncertain. Despite these concerns, underactuated hands have become increasingly popular in robotic and prosthetic applications. Robotic hands are also a venue in which novel, secondary mechanisms are often found. Devices such as differentials, valves, clutches, and low-power, shape-changing actuators have been used to improve grasp robustness on a wider range of objects and allow users more grasping and manipulation options. However, the location and placement of secondary actuators has not been studied in a comprehensive way with respect to the types of actuation methods possible. This is due in part to the lack of general analytic tools which enable designers to rapidly investigate their designs prior to the prototyping stage. Additionally, much of the analysis in the field of robotic hands is done once basic design choices have already been made, making subsequent analyses specific only to a set of design parameters specific to those choices. The same point can be made regarding quality metrics, which suffer from fragmented utilization due to the many different emphases placed on different design requirements. The primary goal of this thesis is to provide a framework for the analysis and evaluation of underactuated robotic hands. The first chapter discusses both the broad motivations for studying robotic hands and the specific contributions of this thesis. The next chapter reviews relevant designs from literature, analyses that have accompanied them, uses of secondary devices in underactuated hands, and the progress that dynamics simulators have made towards representing reality. In the next chapters, the issues related to modeling abstract, generic hand designs is discussed, and a kinematic framework is introduced to derive the force relationships between actuator and grasped object for many mechanisms commonly encountered in underactuated hands. Chapter 6 discusses difficulties associated with solving static force equations, and several methods are introduced to accomplish this. The last of these options relies on three-dimensional rigid-body dynamic simulations to evaluate the performance of compliant, underactuated mechanisms which may encounter conditions such as coulomb friction in contact and and damping at the joints. In the next chapters, these force relationships are derived and discussed for specific hand designs in the context of a force-field representation, and several performance metrics are derived which measure a hand's ability both to acquire and retain objects. The benefits of secondary actuation mechanisms are then discussed with two specific examples. First is the SRI/Stanford/Meka hand, a tendon-driven, compliant, underactuated hand capable of locking individual joints. Second is a mechanism implemented on the Seabed Hand, which increases the range of graspable objects and allows users to selectively change grasp properties based on their specific control needs. Finally, the impacts of friction are discussed, and the trends from simulations are compared with experimental data. From these experiments the benefits of secondary mechanisms can be demonstrated in a frictional world as well.
  • This dissertation describes the design, implementation, and experimentation of an autonomous free-climbing robot, Capuchin. The objective of our project is to create a multi-limbed robot capable of climbing vertical terrain autonomously using techniques similar to those used by human free climbers. When a "free" climber climbs a steep crag or an artificial climbing wall, she uses nothing else but her hands and feet to make contact with terrain features such as holes, cracks, ledges or protrusions. Unlike "aid" climbing, which uses special equipments, tools, or engineered features, free climbing only relies on friction at the contacts between the climber and the terrain. In order to make a multi-limbed robot climb in a similar way, four fundamental challenges must be addressed: robot design, sensing, motion planning and motion control. Our work focuses on robot design (including sensors) and motion control. However, our robot, Capuchin, is an integrated system including a simplified sensing system and a pre-existing motion planner running off-line. A good robot design can increase the inherent ability of the robot to climb complex terrain. It may also lead to better performance and make other issues easier, such as motion planning and control. A four-limb structure was chosen after consideration of the robot's capability and complexity. Simulation was used during the design process to optimize performance, in particular to maximize the workspace reachable by the end-effectors (fingers). Sensors have been selected to allow the robot to both acquire information about the terrain and control its motion. Each finger is equipped with a camera. Vision feedback allows the robot controller to accurately dock the finger on a terrain feature at a location computed by the planner. It also allows modifying a planned trajectory in real-time, when the terrain differs slightly from the model that had been used by the planner or when other small errors occur (for instance, if the robot slips slightly at a contact). Each finger is additionally equipped with a force sensor that gives the magnitude and orientation of the reaction force at a contact. The four force sensors are used by the robot controller to maintain the robot in quasi-static equilibrium, by adjusting the robot posture and the joint torques when needed, so that the reaction forces at the contact point continuously within their Coulomb friction cones. A two-stage motion planner previously developed by Bretl and Hauser for free-climbing and other multi-limbed robots navigating on challenging and irregular terrain is used in this work. This planner decomposes a climbing motion into a sequence of moves, each performed with a fixed set of robot-terrain contacts (this set is called a "stance"). The transition at the end of each move consists of either breaking a contact or making a new one. The planner first computes a sequence of stances. Next it computes a trajectory for the move to be performed at each stance. If it fails to find a move at one step, it considers another sequence of stances. The core part of our research has been the design of the motion controller. The main problem we had to solve is a multi-contact force control problem. One of our most important findings has been the following: for quasi-static climbing, it is not necessary, even not desirable, to continuously control the forces exerted by the robot at the contact points. Instead, it is preferable to continuously monitor these forces and perform joint torque adjustments only when some reaction forces get too close to the boundaries of the friction cones or to their maximal magnitude. This strategy was not obvious when we started our research. In fact, we first developed a motion controller that continuously adjusted joint torques to keep measured reaction forces as close as possible to the terrain normals at the contact points. But computing these adjustments is rather time consuming. Moreover, this approach leads the robot to perform delicate adjustments frequently. As a result, robot motion was neither as smooth, nor as reliable as we would have liked. Instead, our new approach, which we call "lazy" force control, leads to a faster servo rate and much smoother motion. Our experiments show that on average adjustments only amount for a small percentage (less than 10%) of the total time spent climbing. They also demonstrate that Capuchin can reliably climb vertical artificial climbing walls autonomously and can handle small errors in the terrain model used by the planner.
  • Using hybrid x-ray/MR (XMR) systems for image guidance during interventional procedures can enhance the diagnosis and treatment of neurologic, oncologic, cardiovascular, and other disorders. XMR suites have become more available, with various vendors offering dual-modality solutions. These systems combine the three-dimensional imaging capabilities and excellent soft tissue contrast provided by MR with the high spatial/temporal resolution and accurate device tracking provided by x-ray. To eliminate system compatibility concerns, the suites typically have long travel distances between MR and x-ray components. As a result, switching between modalities requires shuttling the patient several meters from one system to the other. Because patients typically have critically placed monitoring systems and intravenous lines for drug delivery and anesthesia, the cumbersome shuttling process impedes repeated switching between the modalities. To circumvent the hurdles associated with alternating between modalities, we proposed a close proximity hybrid system design in which a c-arm fluoroscopy unit is placed immediately adjacent to a closed bore MR system with a minimum distance of 1.2 meters between the x-ray and MR imaging field of views. Placing the x-ray system so close to the MR bore requires an x-ray tube capable of operating in a relatively strong MR fringe field environment. Existing rotating anode x-ray tube designs fail within MR fringe field environments because the magnetic fields alter the electron trajectories in the x-ray tube and act as a brake on the induction motor, reducing the rotation speed of the anode. In my work, I have developed (1) techniques to correct for the altered electron trajectories and (2) a novel motor design that eliminates the reduced rotation speed of the anode. Altering electron trajectories between the cathode and anode affects the location, size, and shape of the x-ray tube focal spot on the anode. I proposed a combination of approaches to control the trajectories. First, I derived an active magnetic shielding design using constrained optimization techniques that minimizes power consumption and heat deposition in the external deflection coils. I then adapted my shielding design to include rare earth permanent magnets, to further reduce the power and size requirements of the coils. Finally, I designed a split-focusing cup that controls the electron trajectories via electrostatic mechanisms, providing an alternative that is more space efficient and MR-compatible. High rotation speed of the anode is needed for sufficient instantaneous heat loading on the target area, to achieve the needed x-ray tube output. There is currently no available motor design to rotate the anode in the expected magnetic environment. To solve this problem, I designed a new motor that operates efficiently within the fringe field. The design is analogous to a modified three-pole brushed DC motor, with the radial component of the MR fringe field replacing the permanent magnet stator field used in conventional brushed DC motors. The motor support bearings provide rotating electrical contacts, while feedback signals from a position sensor control electrical commutation. A vacuum compatible prototype of the proposed motor design was assembled, and its performance was evaluated at various field strengths and orientations. Combining the control mechanisms for the electron trajectories with the new motor design yields a robust x-ray tube capable of operating in fringe fields with magnitudes on the order of 0.1 to 0.2 T.
  • Optical MEMS (Micro-Electro-Mechanical Systems) is an enabling technology that realizes miniaturized optical systems with high functionality and excellent performance. In this dissertation, two novel miniaturized optical systems are presented for applications in optical communication and biomedical imaging. In Part I, a multi-functional MEMS tunable optical filter are described, which is a key element for dynamic wavelength provisioning in reconfigurable optical networks and communication systems. This filter is built based on MEMS platform technology that allows large vertical mirrors (311 [mu]m x 450 [mu]m x 40 [mu]m) to be micro-assembled on actuated platforms to enable compact tunable optical filters with large apertures and high-quality optical mirrors with very low scattering losses. Besides, electrostatic combdrive actuators connected to the MEMS platforms provide independent and continuous control of the center wavelength and the optical bandwidth. The filter has been tested by integrating it in a 10Gb/s communication system. The performance of the MEMS tunable filter is demonstrated for amplified spontaneous emission (ASE) rejection and wavelength selection. In PART II, a 3-D MEMS scanning system utilizing 2-D lateral and 1-D vertical MEMS scanners is introduced for use in miniature in vivo dual-axis confocal (DAC) microendoscopes, which is an emerging biomedical-imaging technology with high resolution, good tissue penetration, large field of view, and ability to provide both reflectance and fluorescence contrast images. Both MEMS scanners are fabricated exclusively by front-side processing to enable compact and robust structures that facilitate handling and packaging for miniaturized optical instrumentation. Co-operation of a 2-D lateral scanner and a 1-D vertical scanner enables fast 3-D microscopy over a volume that measures 340[mu]m by 236[mu]m by 286[mu]m. This part describes the principle of the all-MEMS-based 3-D scanning DAC microscopy that gives the functionality of OCT (real-time vertical cross-section imaging) to a confocal microscope.
  • Over the last several years advances and miniaturization of technology have allowed legged robots to move from the research laboratory to the real world, as evidenced by the large number of flexible platforms only recently available. These platforms are successful, but fall short of capitalizing on the biggest advantage of legs: the ability for high speed locomotion over unstructured terrain. Additionally, no current articulated legged robot is able to perform both static and truly dynamic locomotion, as the actuation technology is not conducive to these two very different regimes of operation. Currently, machines that are dynamic are unable to walk or position themselves accurately, and machines that function very well with static motions are unable to move dynamically. The bipedal robot TRIP (Tendonized Running Inspired Platform) was built to study dynamic maneuvering and control of an articulated legged robot with high-inertia legs. Each leg includes an inelastic tendon which couples ankle joint rotations to knee joint rotations, resulting in simplified effective dynamics and control, and a high degree of passive stabilization with dynamic maneuvers. A hybrid pneumatic-electric actuator was built and tested while driving a knee joint; this actuator is capable of precise positioning, as well as highly energetic thrusting. It will be shown that static and dynamic maneuvers are attainable with a tendon-coupled ankle, and that a tendon allows simpler dynamic control through the concept of impulse compensation, and through the use of passive stabilization from the kinematics resulting from the tendon. Second, it will be shown that the hybrid actuator is superior in some respects to current available technology, both by specification, and by experimental results of static and dynamic maneuvers achieved through its use. And third, using a general heuristic-based control algorithm developed for various sized bipedal machines, dynamic maneuvers are possible with a high leg-to-body moment of inertia ratio, which would show that the control strategy takes into account the dynamics of the legs during high speed locomotion.
  • Biological barriers prevent the uptake of many potentially harmful xenobiotics yet also limit the delivery and cellular entry of a variety of drugs to their targets. One approach to this problem selects only those compounds with appropriate properties, namely solubility in polar biological fluids yet also able to pass through the nonpolar cellular membrane. This restriction would therefore preclude the use of many polar (e.g. siRNA) and nonpolar (e.g. Taxol) compounds whose inherent physical properties cause problems with formulation, distribution or bioavailability. The research described herein utilizes an alternative strategy that involves molecular transporters, which are agents that, when attached to poorly soluble or poorly bioavailable drugs, produce conjugates that exhibit excellent water solubility and simultaneously an increased ability to cross tissue and cell barriers. Bioactivatable molecular transporter conjugates of the immunosuppressant drug Cyclosporin A incorporating disulfide linkers were developed, evaluated for their biological activity in vitro, and administered topically in an in vivo mouse model. In addition to the inherent physical properties limitation that prevents drug passage across the cell membrane, another significant contributor to the failure of many therapeutics is the overexpression of membrane proteins (e.g. P-glycoprotein or Pgp) that mediate the unidirectional efflux of drugs out of target cells, often doing so prior to the drug reaching its intracellular target. Bioactivatable oligoarginine transporter conjugates of Taxol, a substrate for Pgp, were prepared and shown to overcome efflux-mediated resistance in primary human ovarian cancer tissue ex vivo. The encapsulation of transporter conjugates inside biodegradable polymeric nanoparticles was also investigated as a way to achieve sustained release of transporter drug conjugates over extended periods of time, thereby avoiding metabolism or toxicity problems associated with a bolus administration of therapeutic agents. Nanoparticles encapsulating transporter-probe conjugates were formed using two different methods, and shown to release their encapsulated cargo over time under biologically relevant conditions.
  • The protein kinase C isozyme family has been implicated in a number of diseases representing the majority of the most significant challenges to global human health, including cancer, neurodegenerative diseases (Alzheimer's disease, depression, schizophrenia, etc.), cardiovascular disease, HIV/AIDS, diabetes, and chronic pain. As such, potent and selective modulation of this enzyme family using small molecule ligands designed for a particular function has tremendous therapeutic potential. A number of agents have been identified as ligands for the C1 domain of protein kinase C. Many of these compounds, including the endogenous ligand diacylglycerol and the complex bryostatin family of natural products, act by inducing an initial activation event, resulting in the translocation of protein kinase C to the plasma membrane where it can participate in the phosphorylation of downstream serine and threonine residues. The bryostatins are complex macrolides isolated from the marine organism Bugula neritina. Although a number of agents from this family of natural products have been shown to be biologically active, bryostatin 1 in particular has garnered tremendous therapeutic interest owing to its remarkable potency and activity profile. Specifically, bryostatin 1 has been shown to stimulate apoptosis, bolster the immune system, reverse multidrug resistance, synergize with other anticancer agents, enhance memory and learning in rodent models through the induction of synapse formation (synaptogenesis), reverse the effects of stroke in animal models, and induce latent HIV in vitro. As a result of this activity profile, bryostatin 1 is currently in phase I and II clinical trials for cancer treatment and is being advanced to the clinic for the treatment of Alzheimer's disease. However, despite its remarkable clinical potency (often ~ 1 mg is required for a 8 week treatment cycle in humans), the extremely low supply of bryostatin 1 prohibits its continued human clinical use and investigation for the treatment of additional therapeutic indications. In an effort to address the issues associated with the supply and unoptimized nature of a number of complex natural product protein kinase C ligands, the Wender group developed a pharmacophore model for C1 domain binding in the mid 1980s. This resulted in the design and synthesis of highly simplified, functional protein kinase C ligands based on the diacylglycerol scaffold. Additionally, structurally simplified, synthetically accessible bryostatin analogs were designed and shown to have comparable or even superior potency relative to bryostatin 1 for protein kinase C binding and in vitro anticancer activity. Described herein is the design, synthesis, and biological evaluation of a series of macrocyclic diacylglycerol analogs in an effort to improve protein kinase C affinity by reducing the entropic penalty of the binding event relative to the endogenous linear diacylglycerols. The binding affinity was found to be highly dependent on macrocycle size, with the most potent analog being up to two orders of magnitude more potent than the linear diacylglycerols (consistent with previous reports). Moreover, these analogs were prepared in a step-economical fashion (3-4 steps from commercial materials). Additionally, the design and synthesis of members of the first series of B-ring tetrahydropyran bryostatin analogs produced in the Wender group is reported. The use of a novel, high yielding Prins macrocyclization allowed for the retention of the synthetic convergency that has become a hallmark of the B-ring dioxane analogs produced previously in the Wender group. Several compounds from this B- ring tetrahydropyran class were found to be among the most potent analogs produced to date (with respect to protein kinase C affinity and in vitro anticancer activity). Despite the high potency and synthetic accessibility of the previously reported bryostatin analogs, these compounds lacked the ability to activate protein kinase C isozymes (as measured by their ability to induce the translocation of the enzyme from the cytosol to the plasma membrane) with a high degree of selectivity but were not equally non-selective either. The ability to tune isozyme selectivity has tremendous therapeutic potential and, in an effort to address this challenge, a series of A-ring functionalized, B-ring tetrahydropyran analogs was designed and synthesized using the Prins macrocyclization methodology. It was found that the C8 geminal dimethyl group on the A-ring in combination with C7 hydroxyl functionality imparts selectivity for the conventional protein kinase C [Beta]I over the novel protein kinase C [lowercase Delta}. Alternatively, C8 geminal dimethyl functionality in combination with C7 acetate functionality results in a high degree of non-selectivity for these isoforms. C13 functionalization was found to increase the potency of this already highly active analog class. Finally, several of the B-ring tetrahydropyran bryostatin analogs were shown to synergize with taxol in a human leukemia cell line. Additionally, a lead B-ring dioxane bryostatin analog was shown to be capable of inhibiting tumor growth in vivo in a transgenic mouse lymphoma model. Protein kinase C was implicated in this activity by monitoring the phosphorylation of downstream proteins as well as by performing inhibitor studies. This lead analog was also shown to induce apoptosis in a number of human B- and T-lymphocytes. The apoptotic induction observed in the murine cell line used for this pilot in vivo study was found to be independent of direct cell cycle effects. Significantly, this represents the first academic report of bryostatin analog efficacy and safety in vivo.
  • My graduate studies have focused on the design, synthesis, and biological evaluation of novel probe and drug delivery technologies. This research has explored the development of new molecular transporter scaffolds with a focus on step economy and translational costs as well as evaluation of their uptake and delivery properties in cells and animals. Chapter 1 provides a historical context and overview of guanidinium-rich molecular transporter technology. Chapter 2 describes the development of a new family of guanidinium-rich oligocarbonate molecular transporter which are flexibly and efficiently assembled by a one-step oligomerization strategy. These novel oligocarbonate transporters were shown to exhibit excellent uptake properties both in cells and animal models. Chapter 3 is directed at the utility of an oligomerization approach to generate molecular transporters by the design, synthesis, and evaluation of new aphipathic co-oligomers for the delivery of siRNA, an oligonucleotide cargo of intense therapeutic interest. Amphipathic carbonate co-oligomers were prepared by an oligomerization strategy and demonstrated to effectively package, deliver, and release functional siRNA in cells. Chapter 4 describes the effects of a branched guanidinium array on the transport and delivery efficiency of releasable dendrimeric guanidinium-rich transporters. These transporters were synthesized and demonstrated to deliver and release a small molecule for turnover by its intracellular target enzyme by bioluminescence assays in cells and transgenic animal models. Chapter 5 describes the design, synthesis, and preliminary biological evaluation of lipidated molecular transporter derivatives of the immunosuppressant drug rapamycin for topical delivery.
  • My graduate studies have focused on the development of novel drug delivery technologies of research, clinical, and industrial significance. More specifically, my research has focused on the design, synthesis, and application of guanidinium-rich molecular transporters for the delivery of siRNA into cells. My studies have also focused on using molecular transporters to develop the first molecular method to deliver cargo into algae, and on the development of new strategies to control the timing and amount of drug or probe release in cells. Though all of this research is fundamentally based on organic chemistry, these projects have broad applications in research, industrial and clinical settings. Chapter 1 reviews the strategies that have been developed for the delivery of siRNA in both cells and animals. Rather than divide the field by chemical type (e.g. peptide vs. protein) or disease indication, this review categorizes siRNA deliver agents by the identity of their cationic moiety for siRNA complexation. Guanidinium-containing delivery vectors are presented, as are vectors containing ammonium and phosphonium groups. Highlighting this field by cationic moiety reveals how little research has been done to compare the effects of the cation's identity on deliver efficacy, toxicity, and pharmacokinetics. Chapter 2 describes the design, synthesis, and evaluation of guanidinium-rich amphipathic oligocarbonate molecular transporters for the complexation, delivery, and release of siRNA in cells. The synthetic ease of the metal-free carbonate oligomerization to synthesize these transporters afforded fast access to a series of transporters that systematically probed the functionality required for effective complexation, delivery, and release of siRNA. Transporters were characterized and evaluated for biological activity in immortalized human keratinocytes. The transporters discovered in this study were highly effective, with target gene silencing of up to 90% observed. Chapter 3 focuses on efforts towards expanding the scope of both the chemical space and cell types tested in the delivery of siRNA with amphipathic oligocarbonate molecular transporters. These second generation delivery systems have improved physical properties, including smaller and more stable particle sizes, relative to their first generation counterparts described in Chapter 2. These transporters delivered siRNA to primary keratinocytes, melanoma cells, and ovarian cancer cells. Chapter 4 details the development of the first molecular method for the delivery of small molecule probes and large protein cargos into algal cells. It was shown that oligoarginine could facilitate the uptake of fluorescein, or the larger, FAM-streptavidin protein, into cells. A catalytically active protein was delivered into cells and was shown to maintain catalytic activity even after delivery. Chapter 5 describes the design of new strategies to control the timing and amount of cargo released inside cells. Efforts towards a novel linker carrying two copies of drug or probe are described, as well as the combination of microneedles and luciferin-transporter conjugates for transdermal delivery in vivo.
  • In this work, a function-oriented array of simplified analogs of the daphnane diterpene orthoester class of natural products bearing palmitate, phenyl, or phenylacetyl orthoesters was synthesized starting from commerically available starting materials via a key late stage common diversification intermediate. These families of novel compounds were evaluated for both selective PKC activation and growth inhibition of K562 (myleogenous leukemia) cancer cells. While these analogs showed no growth inhibitory activity in K562 cells up to concentrations of 10 micromolar, they did display varying profiles of PKC activation. One analog in particular demonstrated the ability to activate and cause translocation of conventional PKC b1 and novel PKC d to the same extent as resiniferonol, a potent natural resiniferonoid. A second analog, however, was found to activate novel PKC d selectively over conventional PKC b1; surprisingly, resiniferonol did not share this selectivity profile. Because the simplified, functional analogs synthesized in this study were shown to activate PKC while having no growth inhibitory activity, these compounds should be further investigated for their potential as therapeutic leads for the treatment of diseases like Alzheimer's or Parkinson's, in which (selective) activation of PKC could serve a therapeutic purpose without being plagued by growth inhibitory pathways.
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    "Combining the latest thinking about mixed methods research designs with practical, step-by-step guidance, the Second Edition of Designing and Conducting Mixed Methods Research now covers six major mixed methods designs. Authors John W. Creswell and Vicki L. Plano Clark walk readers through the entire research process, from formulating questions to designing, collecting data, and interpreting results and include updated examples from published mixed methods studies drawn from the social, behavioral, health, and education disciplines."--pub. desc.
  • Purified DNA serves as a template for a wide array of analysis techniques, ranging from sequencing to PCR and hybridization assays. DNA analysis can be used for clinical diagnosis, for forensic investigation, and for a range of research purposes. These analysis techniques improve each year, but they are all constrained by the availability of purified DNA. DNA is typically derived from raw biological samples that contain a host of other molecular species, including proteins, lipids and metal ions. These species can inhibit analysis of the DNA, so purification of DNA from complex sample matrices is a necessary precursor to analysis. Typically, DNA purification is performed using either liquid-liquid extraction or solid-phase extraction, both of which require manual labor, involve toxic chemicals, and are difficult to miniaturize. Isotachophoresis (ITP) is an alternative method for DNA purification that does not rely on specialized surface chemistry or toxic chemical species. Instead, ITP uses electric fields to selectively pre-concentrate DNA from a raw sample, and simultaneously separate it from inhibiting species. ITP purification of DNA has been demonstrated from human serum, plasma, and whole blood, and the same technique has been used to purify RNA from bacteria in human blood and urine. Until recently, the parameters governing extraction efficiency, throughput, and separation quality in ITP purification were not well established. This thesis is focused on rational analysis for designing and optimizing ITP systems for rapid, high quality DNA purification.
  • Also available: Print – 2007
    Designing a randomized blinded trial / Steven R. Cummings, Deborah Grady, and Stephen B. Hulley -- Alternative trial designs and implementation issues / Deborah Grady, Steven R. Cummings, and Stephen B. Hulley -- Designing studies of medical tests / Thomas B. Newman ... [et al.] -- Utilizing existing databases / Deborah Grady and Norman Hearst -- Addressing ethical issues / Bernard Lo -- Designing questionnaires and interviews / Steven R. Cummings and Stephen B. Hulley -- Data management / Michael A. Kohn -- Implementing the study and quality control / Deborah Grady and Stephen B. Hulley -- Community and international studies / Norman Hearst and Thomas E. Novotny -- Writing and funding a research proposal / Steven R. Cummings and Stephen B. Hulley. Getting started: the anatomy and physiology of clinical research / Stephen B. Hulley, Thomas B. Newman, and Steven R. Cummings -- Conceiving the research question / Steven R. Cummings, Warren S. Browner, and Stephen B. Hulley -- Choosing the study subjects: specification, sampling, and recruitment / Stephen B. Hulley, Thomas B. Newman, and Steven R. Cummings -- Planning the measurements: precision and accuracy / Stephen B. Hulley, Jeffrey N. Martin and Steven R. Cummings -- Getting ready to estimate sample size: hypotheses and underlying principles / Warren S. Browner, Thomas B. Newman, and Stephen B. Hulley -- Estimating sample size and power: applications and examples / Warren S. Browner, Thomas B. Newman, and Stephen B. Hulley -- Designing a cohort study / Steven R. Cummings, Thomas B. Newman, and Stephen B. Hulley -- Designing cross-sectional and case-control studies / Thomas B. Newman ... [et al.] -- Enhancing causal inference in observational studies / Thomas B. Newman, Warren S. Browner, and Stephen B. Hulley --
  • Also available: Print – 2013
    "This book provides a practical guide to planning, tabulating, formulating, and implementing clinical research, in an easy-to-use, readable presentation"--Provided by publisher.
  • "Clear, polished, and stimulating presentations are as important to the scientific profession as they are to business, yet most scientists never receive formal training in the creation, delivery, and evaluation of such material." ... "Designing Science Presentations provides visually intensive guidance at every step-from the construction of original figures to the presentation and delivery of those figures in papers, slideshows, posters, and websites." --Excerpts from publisher's description.
  • "As simple and straightforward as two health professionals conferring over the telephone or as complex and sophisticated as robotic surgery between facilities at different ends of the globe, telehealth is an increasingly frequent component in healthcare. A primer on the human factors issues that can influence how older adults interact with telehealth systems, Designing Telehealth for an Aging Population: A Human Factors Perspective examines the new ways patients and healthcare providers communicate to achieve the same or better outcomes than with traditional face-to-face healthcare.The authors examine older adult capabilities and provide standards and guidelines for telehealth design, enlivened by clinical examples and tutorials on human factors methodologies. They take a systematic look at how the use of human factors principles can facilitate the successful development, deployment, and maintenance of telehealth technology to better serve the aging population. The authors have carefully stayed away from academic writing, distilling their experience in the form of basic observations and principles drawn from their work. They include suggested readings at the end of each chapter that supply the research underpinning their recommendations. The first reference to cover older adult users in an area that will only get bigger, this book sets itself apart by providing focused coverage of the human factors issues specific to aging populations and practical advice on how to accommodate them"-- Provided by publisher.
  • Part I Designing the User Study -- Overview -- Variables -- Design equation and statistics -- Between-subjects design -- Within-subject designs -- Advanced designs -- Part II Practical Tips -- Understanding main and interaction effects -- Conducting multiple comparisons -- Gold standard and user evaluations -- Recruiting and motivating study participants -- Institutional review board (IRB) approval -- Resources -- Part III Common Mistakes to Avoid -- Avoid bias -- Avoid missing the effect -- Avoid missing variables or conditions -- Other errors to avoid -- Appendix: cookbook for designing user studies in informatics.
  • Also available: Print – 2008
  • The pharmacokinetic basis of therapeutics -- The pharmacodynamic basis of therapeutics -- Adverse reactions and drug-drug interactions -- Herb-drug interactions -- Food-drug interactions.
  • Desmoid tumors 2011
    Clinical Presentation of Desmoid Tumors -- Pathology of Desmoid Tumors -- APC/β-Catenin Deregulation in Desmoid Tumors: Important Implications for Diagnosis, Prognosis, and Therapy -- Imaging Techniques in Desmoid Tumors -- Surgical Management of Desmoid Tumors -- Systemic Therapy in the Treatment of Desmoid Tumors -- Radiation Therapy for Desmoid Tumors -- Interventional Radiology -- Introduction -- Desmoid Disease in Familial Adenomatous Polyposis -- Desmoid Tumor in Children and Adolescents: The Influence of Age -- Microarrays and High-Throughput Sequencing in Desmoid-Type Fibromatosis and Scar -- Desmoid Tumors: Are They Benign or Malignant? -- The Role of Patient Advocacy Groups in Rare Tumors Such as Desmoid Tumors.
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  • Understanding human brain function is one of the most important endeavors in modern science. There is growing evidence that cognitive functions are executed by large-scale networks, comprising multiple interacting anatomically-connected brain areas. Although considerable progress has been made in understanding which specific brain areas are involved in particular cognitive functions, very little is known about the integrative functioning of large-scale brain networks. This is due in part to the lack of methods to pursue this line of research. This dissertation describes computational methods for detecting and characterizing large-scale human brain networks, combining data from task-free functional magnetic resonance imaging (fMRI) and structural diffusion tensor imaging (DTI), two complementary brain imaging modalities. Application of our methods to task-free fMRI and DTI data obtained from a wide range of subject populations provided new insights into how large-scale human brain networks develop, mature, and get disrupted in psychiatric and neurological disorders. More generally, this work demonstrates the power of our multimodal network-analytic approach to obtain a system-level understanding of brain function across the human lifespan.
  • Due to the sequential nature of magnetic resonance imaging (MRI) data acquisition, correction of image artifacts originating from involuntary patient motion is essential for reliable diagnostic quality. Especially during MRI scans of certain patient populations such as children, elderly or patients with certain medical conditions (e.g. stroke, Parkinson's), motion correction methods must be incorporated into the MR imaging protocol for adequate image quality. With increased demands for higher resolution or time-resolved examinations (e.g. functional MRI), examination times also increase and even willing patients might have trouble staying still during the course of the examination. The first part of this thesis provides a method for retrospective correction of head motion artifacts using a multi-shot spiral-in \& out readout and parallel-imaging based iterative image reconstruction. The spiral-in part provided a low resolution image that was used for measurement of head motion. Due to rotational motion, locally undersampled areas appear in MR acquisition space (i.e., k-space), which violate the Nyquist theorem and cause artifacts even after motion correction. These artifacts were addressed through the data redundancy provided by multiple receiver channels that is present in modern receiver coils and an iterative conjugate-gradient based reconstruction. This method was then applied to diffusion tensor imaging (DTI) with multi-shot readout. Since DTI uses directional gradients to encode diffusion, rotational motion causes the image contrast to change, and it becomes incorrect to combine data with varying diffusion encodings on them. To address this issue, a non-linear conjugate gradient based reconstruction is presented and it is shown that this method provided more accurate description of white matter pathways compared to traditional methods. In the second part of this thesis, a prospective motion correction system using an optical tracking device is presented. Such systems are preferable compared to retrospective navigator-based methods due to various reasons, such as ability to perform motion correction independent of the MR data acquisition and immunity to spin history effects. The system proposed used a single camera mounted on the head coil and a self-encoded checkerboard marker mounted on the patient's forehead. Results on structural and diffusion imaging revealed that prospective motion correction outperforms retrospective navigator-based schemes. In the last part of the thesis, entropy-based retrospective autofocusing was used in combination with motion data obtained from prospective tracking to remove residual motion artifacts in the images. This method was especially useful for removing errors caused by inaccurate cross-calibration between the scanner and camera frame-of-references. It was also shown that prospective tracking can be the enabling technology for autofocusing in 3D acquisitions.
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  • In the era of rapid high-throughput DNA sequencing and increasing bioinformatic capabilities to analyze large amounts of biological data, it is especially important to continue to develop high-throughput experimental proteomic methods. Probing physical interactions among proteins and nucleic acids is a powerful approach to gain insight into their functional relationships. Microfluidic tools are of great potential value to this field because they make it possible to run hundreds or thousands of independent experiments in parallel and at a high spatial density. Here I present and explain MITOMI (mechanically induced trapping of molecular interactions), an in vitro method that was initially created to measure the affinities of transcription factors binding to DNA. I contributed to the development of the system so it could be applied to mapping protein-protein interaction networks, and used it to study the interactions of E. coli RNA polymerase in order to better understand the regulation of bacterial transcription. I also extended the utility of MITOMI by adapting it to be able to measure interaction kinetics and to more efficiently measure affinities. With the ability to discover interactions at a large scale and to quantitatively characterize them on the same platform, MITOMI constitutes a valuable contribution to proteomic methodology.
  • Introduction : how the detection, assessment, diagnosis and monitoring of caries integrate with personalized caries management / Pitts, N.B. -- Clinical visual caries detection / Topping, G.V.A., Pitts, N.B. -- Traditional lesion detection aids / Neuhaus, K.W. ... [et al.] -- Novel lesion detection aids / Neuhaus, K.W. ... [et al.] -- Lesion activity assessment / Ekstrand, K.R. ... [et al.] -- Patient caries risk assessment / Twetman, S., Fontana, M. -- Dentition and lesion history / Eggertsson, H., Ferreira-Zandona, A. -- Assessing patients' health behaviours : essential steps for motivating patients to adopt and maintain behaviours conducive to oral health / Freeman, R., Ismail, A. -- Personalized treatment planning / Pitts, N.B., Richards, D. -- Background level care / Pitts, N.B. -- Traditional preventive treatment options / Longbottom, C., Ekstrand, K.R., Zero, D.T. -- Novel preventive treatment options / Longbottom, C. ... [et al.] -- Traditional operative treatment options / Ricketts, D.N.J., Pitts, N.B. -- Novel operative treatment options / Ricketts, D.N.J., Pitts, N.B. -- Recall, reassessment and monitoring / Clarkson, J.E. ... [et al.] -- Implementation : improving caries detection, assessment, diagnosis and monitoring / Pitts, N.B -- Glossary of key terms / Longbottom, C. ... [et al.].
  • Part 1. BIOTERRORISM PREVENTION -- Bioterrorism: A Potential Weapon for Terrorist Attacks Through Food and Water Contamination: Evolution of Our Understanding of the Use of Chemical and Bacteriological Weapons / Vincenzo Costigliola and Franco Quagliata -- Detection and Quantification of Bacteria and Fungi Using Solid-Phase Cytometry / Lies ME Vanhee, Eva D'Haese, Ils Cools, Hans J Nelis and Tom Coenye -- Vulnerability Assessment and Mapping of Akounq Groundwater Body, Armenia / Vahram Vardanyan and Artashes Aginian -- Part 2. BACTERIA DIAGNOSTIC TESTS -- Methods for Detection of Shiga-Toxin Producing Escherichia coli (STEC) / Jordan Madic -- Genetic Diversity of Enterococci in Bryndza Cheese / Roman Dušinský, Anna Belicová, Libor Ebringer, Dušan Jurkovič and Lívia Križková, et al. -- Salmonella Infections / Constantine Arvanitakis -- Molecular Diagnostics of Staphylococcus aureus / Jiří Doškař, Roman Pantůček, Vladislava Růžičková and Ivo Sedláček -- Molecular Methods to Detect Bacillus cereus and Bacillus thuringiensis in Foods / Marisa Manzano, Lucilla Iacumin, Cristina Giusto and Giuseppe Comi -- Control of Listeria monocytogenes in San Daniele Dry Cured Ham by Different Technologies: Reduction of L. Monocytogenes in Dry Cured Ham / Lucilla Iacumin, Marisa Manzano, Milena Osualdini, Carlo Cantoni and Giuseppe Comi -- Part 3. VIRAL INFECTIONS -- Epidemiology and Diagnosis of Hepatitis B in the Mediterranean Region and Elsewhere / Nurdan Tözün, Özdal Ersoy, Fatih Eren and Veysel Tahan -- Hepatitis E Virus (HEV) - An Emerging Viral Pathogen / Avrelija Cencič and Walter Chingwaru -- Dengue Virus Diagnostics / Evgeni Eltzov, Danit Atias, Levi Gheber and Robert S. Marks -- Part 4. PARASITES AND FUNGI -- Infectious Forms of Parasites in Food: Man Embedded in Ecosystems / Eduardo Dei-Cas, Cécile-Marie Aliouat, Gabriela Certad, Colette Creusy and Karine Guyot -- Unusual Developmental Pattern of Expression of Enzymes Involved in DNA Biosynthesis in Trichinella spiralis and Trichinella pseudospiralis / Magdalena Dąbrowska, Barbara Gołos, Elżbieta Wałajtys-Rode, Patrycja Wińska and Joanna Cieśla, et al. -- Immunodulation and Helminths: Towards New Strategies for Treatment of Immune-Mediated Diseases? / Fabrizio Bruschi, Lorena Chiumiento and Gianfranco Del Prete -- Parasites and Oncogenesis with a Special Reference to Gastro-Intestinal Neoplasia Induced by Cryptosporidium parvum / C Creusy, G Certad, K Guyot and E Dei-Cas -- Smart Biosensors for Determination of Mycotoxines / Lyubov Yotova, Ivo Grabchev, Rossica Betcheva and Dessislava Marinkova.
  • Health and wellness / Susan Hatters Friedman, Joy Stankowski, and Martha Sajatovic -- City living and mental health in history / Sandro Galea, Emily Goldmann, and Andrea Maxwell -- Mental health, mental health courts, and minorities / Lara Nochomovitz and Franklin J. Hickman -- Migration and mental health / Sana Loue -- Media, minorities, and the stigma of mental illness / Sandra S. Swantek -- Minority mental health and wellness: a perspective from health care systems / Siran M. Koroukian -- Social support, mental health, minorities, and acculturative stress / Deborah Goebert -- Religion and mental health among minorities and immigrants in the U.S. / Anahí Viladrich and Ana F. Abraído-Lanza -- Cultural considerations regarding perspectives on mental illness and healing / Declan T. Barry and Mark Beitel -- Gender and minority mental health: the case of body image / Laura Simonelli and Leslie J. Heinberg -- Family determinants of minority mental health and wellness / Stevan Weine and Saif Siddiqui -- Family-focused psychoeducational programs for minorities with serious mental illness / Amy Weismann de Mamani ... [et al.] -- Socioeconomic status: risks and resilience / Lara M Stepleman, Dustin E. Wright, and Kathryn A. Bottonari -- Psychiatric genetics: an update / Prashant Gajwani -- Substance abuse in minority populations / W.A. Vega and A. G. Gil -- Neurocognitive testing of minorities in mental health settings / Amir Poreh and Alya Sultan -- Stress and resilience / AnnaMaria Aguirre McLaughlin, Lisa Stines Doane, Alice L. Costiuc and Norah C. Feeney -- Methodological challenges in research on the determinants of minority mental health and wellness / Peter Guarnaccia.
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    Human articular cartilage can degrade, losing functional quality and eventually exposing bone surfaces; when significantly advanced, this cartilage degradation can be diagnosed as osteoarthritis (OA). Currently, knee OA can be diagnosed only when the disease is advanced and the patient is suffering from pain. There is no cure for knee OA, nor are there prevent preventative therapies; current treatment strategies relieve the pain of OA or completely replace the knee joint. To evaluate potential therapies and treatments, we need a method that can identify and measure changes to cartilage prior to the onset of degradation. Magnetic resonance imaging (MRI) is a potentially powerful tool to non-invasively evaluate the progression of knee OA by mapping MR image parameters to molecular and material properties that are known to change with disease. The goal of this dissertation was to determine MR image parameters that can be used to evaluate the progression of OA. We examined the biphasic and viscoelastic models of cartilage to determine cartilage material properties from indentation creep tests. We compared initial elastic modulus and cartilage macromolecules to MRI parameters, specifically T2 and T1rho relaxation times and T1rho dispersion. We determined that a predictive model based on T1rho relaxation time maps, which accounts for T2 relaxation time and the effects of age, may estimate longitudinal trends in GAG content in the same person. In addition, a simple T1rho dispersion estimate has the potential for substantial clinical impact by measuring changes in cartilage initial elastic modulus and macromolecules non-invasively. This work is an important step toward developing clinical methods for evaluating cartilage functional condition, and in turn, to advance work towards preventing and treating knee OA.
  • Print Material
    Basic terms and concepts -- Statistical power analysis -- Confidence intervals: measures of precision -- Computer-intensive methods -- Additional considerations, recommendations, and conclusions -- Worked examples.
  • Also available: Print – 1981

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