Lane Medical Library

""Doubt is our product," a cigarette executive once observed, "since it is the best means of competing with the 'body of fact' that exists in the minds of the general public. It is also the means of establishing a controversy."" "In this expose, David Michaels reveals just how prevalent - and how effective - such strategies have become. He argues that to keep the public confused about the hazards posed by global warming, secondhand smoke, asbestos, lead, plastics, and many other toxic materials, industry executives have hired unscrupulous scientists and lobbyists to dispute the scientific evidence that would alert the public to these dangers. Their goal is the manufacture of doubt."--BOOK JACKET.

Therapeutic approaches in the improvement of cognitive performance in Down syndrome: past, present, and future / R. de la Torre and M. Dierssen -- Genomic determinants in the phenotypic variability of Down syndrome / A. Letourneau and S.E. Antonarakis -- Intellectual disabilities, neuronal posttranscriptional RNA metabolism, and RNA-binding proteins: three actors for a complex scenario / B. Bardoni ... [et al.] -- Aberrant epigenetic landscape in intellectual disability / J.V. Sanchez-Mut, D. Huertas and M. Esteller -- Pathways to cognitive deficits in Down syndrome / X. Sturgeon ... [et al.] -- Neurological phenotypes for Down syndrome across the life span / I.T. Lott -- Human and mouse model cognitive phenotypes in Down syndrome: implications for assessment / J.O. Edgin ... [et al.] -- Perturbation of dendritic protrusions in intellectual disability / J. Levenga and R. Willemsen -- The in vivo Down syndrome genomic library in mouse / Y. Herault ... [et al.] -- Discoveries in Down syndrome: moving basic science to clinical care -- A.M. Kleschevnikov ... [et al.] -- A Sonic hedgehog (Shh) response deficit in trisomic cells may be a common denominator for multiple features of Down syndrome / D.G. Currier, R.C. Polk and R.H. Reeves -- Gene therapy for Down syndrome / C. Fillat and X. Altafaj.

Drosophila melanogaster and the development of biology in the 20th century / Alfonso Martinez Arias -- Getting started : an overview on raising and handling Drosophila / Hugo Stocker and Peter Gallant -- FlyBase : a database for the Drosophila research community / Rachel Drysdale and the FlyBase Consortium -- The use of P-element transposons to generate transgenic flies / André Bachmann and Elisabeth Knust -- The GAL4 system : a verstile system for the expression of genes / David A. Elliott and Andrea H. Brand -- P-element mutagenesis / Thomas Hummel and Christian Klämbt -- EMS screens : from mutagenesis to screening and mapping / Christian Bökel -- RNAi screening in cultured Drosophila cells / Sandra Steinbrink and Michael Boutros -- Methods for homologous recombination in Drosophila / Keith A. Maggert, Wei J. Gong, and Kent G. Golic -- Recombinases and their use in gene activation, gene inactivation, and transgenesis / Johannes Bischof and Konrad Basler -- Cuticle preparation of Drosophila embryos and larvae / Cyrille Alexandre -- Immunolabeling of embryos / H.-Arno J. Müller -- Imaging cellular and molecular dynamics in live embryos using fluorescent proteins / Matthieu Cavey and Thomas Lecuit -- Analysis of neuromuscular junctions : histology and in vivo imaging / Andreas Schmid and Stephan J. Sigrist --Immunolabeling of imaginal discs / Thomas Klein -- Imaging Drosophila pupal wing morphogenesis / Anne-Kathrin Classen ... [et al.] -- Microscopic analysis of the adult Drosophila retina using semithin plastic section / Konstantin Gaengel and Marek Mlodzik -- Fluorescent in situ hybridization protocols in Drosophila embryos and tissues / Eric Lécuyer, Neela Parthasarathy, and Henry M. Krause -- Linear RNA amplification for the production of microarray hybridization probes / Ansgar Klebes and Thomas B. Kornberg -- An overview of the identification, detection, and functional analysis of Drosophila microRNAs / Nicholas S. Sokol -- Extraction and immunoblotting of proteins from embryos / Andreas Wodarz -- Purification of Drosophila protein complexes for mass spectrometry / Christoph Jüschke and Jürgen A. Knoblich -- Mass production of Drosophila embryos and chromatographic purification of native protein complexes / Natascha Kunert and Alexander Brehm -- Flow cytometric analysis of Drosophila cells / Aida Flor A. de la Cruz and Bruce A. Edgar -- Drosophila cell lines as model systems and as an experimental tool / Buzz Baum and Lucy Cherbas -- Appendix : phenotypic markers in Drosophila / Jennifer Childress and Georg Halder.

Criminalistics: introduction to controlled substances / Joseph P. Bono -- Pathology of drug abuse / edited by Charles V. Wetli -- Pharmacokinetics: drug absorption, distribution, and elimination / Amanda J. Jenkins -- Pharmacodynamics / edited by Stephen J. Heishman -- Alcohol / edited by Alan Wayne Jones -- Neurochemistry of drug abuse / edited by Julie K. Staley and Kelly P. Cosgrove -- Addiction medicine / edited by Kim Wolff -- Medical complications of drug abuse / edited by Neal L. Benowitz -- Sports / edited by Marc D. Bollmann and Martial Saugy -- Workplace testing / edited by Yale H. Caplan and Marilyn A. Huestis -- Point of collection drug testing / edited by Dennis J. Crouch -- Post-mortem toxicology / edited by Henrik Druid -- Toxicogenetics / edited by Steven B. Karch -- Drug law -- Appendices.

Depressants -- Alcoholism: an introduction -- Alcoholism: acute treatment -- Stimulants: amphetamines and cocaine -- Opioids and other analgesics -- Cannabinols -- Hallucinogens and related drugs -- Glues, inhalants and aeorsols -- Over-the-counter (OTC) drugs and some prescription drugs -- Xanthines (caffeine) and nicotine -- Multidrug abuse and dependence -- Emergency problems: a quick overview -- Rehabilitation.

Part I. Studies of Membrane Permeability and Oral Absorption -- ch. 1. Physico-Chemical Approaches to Drug Absorption / Han van de Waterbeemd, p. 1-20 -- ch. 2. High-Throughput Measurement of log D and pKa / John E. A. Comer, p. 21-45 -- ch. 3. High-throughput Measurement of Permeability Profiles / Alex Avdeef, p. 46-71 -- ch. 4. Caco-2 and Emerging Alternatives for Prediction of Intestinal Drug Transport: A General Overview / Per Artursson and Staffan Tavelin, p. 72-89 -- ch. 5. Cell Cultures in Drug Discovery: An Industrial Perspective / Anna-Lena Ungell and Johan Karlsson, p. 90-131 -- ch. 6. Use of Animals for the Determination of Absorption and Bioavailability / Chris Logan, p. 132-154 -- ch. 7. In Vivo Permeability Studies in the Gastrointestinal Tract of Humans / Niclas Petri and Hans Lennernäs, p. 155-188 -- Part II. Drug Dissolution and Solubility -- ch. 8. Gastrointestinal Dissolution and Absorption of Drugs / Gladys E. Granero, Chandrasekharan Ramachandran and Gordon L. Amidon, p. 189-214 -- ch. 9. Aqueous Solubility in Discovery, Chemistry, and Assay Changes / Chris Lipinski, p. 215-231 -- ch. 10. Factors Influencing the Water Solubilities of Crystalline Drugs / James W. McFarland, Chau M. Du and Alex Avdeef, p. 232-242 -- Part III. Role of Transporters and Metabolism in Oral Absorption -- ch. 11. Transporters in the GI Tract / Ho-Chul Shin, Christopher P. Landowski, Duxin Sun and Gordon L. Amidon, p. 243-287 -- ch. 12. Hepatic Transport / Hiroshi Suzuki and Yuichi Sugiyama, p. 288-310 -- ch. 13. The Importance of Gut Wall Metabolism in Determining Drug Bioavailability / Kevin Beaumont, p. 311-328 -- ch. 14. Modified Cell Lines / Charles L. Crespi, p. 329-338 -- Part IV. Computational Approaches to Drug Absorption and Bioavailability -- ch. 15. Intestinal Absorption: The Role of Polar Surface Area / Per Artursson and Christel A. S. Bergström, p. 339-357 -- ch. 16. Calculated Molecular Properties and Multivariate Statistical Analysis in Absorption Prediction / Ulf Norinder and Markus Haeberlein, p. 358-405 -- ch. 17. VOLSURF: A Tool for Drug ADME-Properties Prediction / Gabriele Cruciani, Mirco Meniconi, Emanuele Carosati, Ismael Zamora and Raimund Mannhold, p. 406-419 -- ch. 18. Simulation of Absorption, Metabolism, and Bioavailability / Michael B. Bolger, Balaji Agoram, Robert Fraczkiewicz and Boyd Steere, p. 420-443 -- ch. 19. Prediction of Bioavailability / Arun K. Mandagere and Barry Jones, p. 444-460 -- ch. 20. Towards P-Glycoprotein Structure-Activity Relationships / PD Anna Seelig, Ewa Landwojtowicz, Holger Fischer and Xiaochun Li Blatter, p. 461-492 -- Part V. Drug Development Issues -- ch. 21. Application of the Biopharmaceutic Classification System Now and in the Future / Bertil Abrahamsson and Hans Lennernäs, p. 493-531 -- ch. 22. Prodrugs / Bente Steffansen, Anne Engelbrecht Thomsen and Sven Frokjaer, p. 532-546 -- ch. 23. Modern Delivery Strategies: Physiological Considerations for Orally Administered Medications / Clive G. Wilson, p. 547-568.

Drug delivery systems--an overview / Kewal K. Jain -- The role of the adeno-associated virus capsid in gene transfer / Kim M. Van Vliet ... [et al.] -- Delivering small interfering RNA for novel therapeutics / Patrick Y. Lu and Martin C. Woodle -- Catheters for chronic administration of drugs into brain tissue / Michael Guarnieri, Benjamin S. Carson, Sr., and George I. Jallo -- Transdermal drug delivery systems : skin perturbation devices / Marc B. Brown ... [et al.] -- Controlling the release of proteins/peptides via the pulmonary route / Sunday A. Shoyele -- Engineering protein particles for pulmonary drug delivery / Sunday A. Shoyele -- 2B-Trans technology : targeted drug delivery across the blood-brain barrier / Pieter J. Gaillard and Albertus G. de Boer -- Drug delivery in cancer using liposomes / Crispin R. Dass -- pH-responsive nanoparticles for cancer drug deliery / Youqing Shen ... [et al.] -- Extended-release oral drug delivery technologies : monolithic matrix systems / Sandip B. Tiwari and Ali R. Rajabi-Siahboomi.

"Drug delivery technologies represent a vast and vital area of research and development in pharmaceutics. The demand for innovative drug delivery systems continues to grow, and this growth drives a variety of new developments. Building on the foundation provided by the second edition, Drug Delivery Systems, Third Edition covers the latest in research, development, and regulations in industry and academia.The third edition of this popular book provides a comprehensive review of the latest research and development on drug delivery systems (including liposomal, transmucosal, transdermal, oral, polymeric, and monoclonal antibody directed delivery); it also contains a new chapter on nanoscience and technology for drug delivery along with cutting-edge business intelligence and strategies. These topics are spread into five sections: Site-specific drug delivery Polymers and implantable drug delivery systems Oral drug delivery Transdermal, transmucosal, ocular, and miscellaneous drug delivery systems Regulatory considerations and global outlook Written in a straightforward, clear, and concise manner, the authors provide a global perspective on current and future advances and market opportunities. The book answers the need for comprehensive information in a single resource for anyone venturing into this area of drug development and who desires an overview of the field, with extensive guidance on where to gain more information. Each chapter provides a table of marketed and investigational products, with numerous practical examples; the book also provides readers with a multitude of possible drug delivery systems that can be used to improve therapeutics, along with global and regulatory perspectives"--Provided by publisher.

Section I, Safety pharmacology: -- Introduction to safety pharmacology -- Status of safety pharmacology and present guidelines -- Central nervous system (CNS) safety pharmacology studies -- Methods in cardiovascular safety pharmacology -- Safety pharmacology of drugs for the urinary tract -- Respiratory function assays in safety pharmacology -- Metabolism pharmacology -- Peripheral nervous system -- Safety of intravenous and inhalation anesthetics -- Side effects of central analgesic drugs -- Safety pharmacology of antiinflammatory drugs -- Safety pharmacology of drugs with osteoarthritis-related activity -- Safety pharmacology of blood constituents -- Ocular toxicity tests -- Assays in endocrine safety pharmacology -- Safety assays in skin pharmacology -- Magnetic resonance imaging in pharmaceutical safety assessment --Section II, Safety pharmacokinetics: -- Introduction -- Physicochemical properties -- In-silico ADME modeling -- Absorption-in vitro tests-cell based -- Absorption-in vitro tests-non cell based -- Distribution-in vitro tests-protein binding -- Perfused organs -- Metabolism studies in vitro and in vivo -- Distribution-across barriers -- Drug-drug interaction-enzyme induction -- Drug-drug interaction-enzyme inhibition -- Absorption -- In vivo distribution -- Distribution-in vivo-other methods -- Bioanalytical assays-Toxicokinetics -- Bioanalytical assays-liquid chromatography coupled to tandem spectrometry -- Bioanalytical assays-gas chromatography -- Bioanalytical assays-RIA/EIA -- Clinical studies-typical designs -- Pharmacogenomics in DME -- Typical PK/PD approaches -- Population kinetics in drug development --Section III, Safety toxicology: -- Introduction -- International guidelines for the development of pharmaceutical compounds -- General toxicity -- In silico methods -- Alternative methods for carcinogenicity testing -- Genotoxicity -- Reproductive toxicology -- Application of toxicoproteomics in profiling drug effects.

Introduction. Drug discovery in the 21st century --ch. 1.Natural products /Charles B. Spainhour --ch. 2.Cancer cell proteomics using molecular aptamers /Weihong Tan ... [et al.] --ch. 3.Molecular similarity methods and QSAR models as tools for virtual screening /Jürgen Bajorath --ch. 4.Systems biology : applications in drug discovery /Sean Ekins ...[et al.] --ch. 5.High throughput flow cytometry /Larry A. Sklar ... [et al.] --ch. 6.Combining NMR spectral information with associated structural features to form computationally nonintensive, rugged, and objective models of biological activity /Richard D. Beger, Dan A. Buzatu, and Jon G. Wilkes --ch. 7.Using Microsoft Excel as a laboratory data management tool /A. Erik Rubin, Mark F. Russo, and William Neil --ch. 8.Age of regulation /Sandy Weinberg and Gerald J. Whartenby --ch. 9.Simultaneous screening of multiple cell lines using the CellCard system /Oren E. Beske --ch. 10.Protein X-ray crystallography in drug discovery /Peter Nollert ... [et al.] --ch. 11.Biological and chemistry assays available during drug discovery and developability assessment /Duane B. Lakings --ch. 12.Strategies and methods in monitoring and targeting protein-protein interactions /Arianna Loregian and Giorgio Palù --ch. 13.High-throughput screening : evolution of technology and methods --Martyn N. Banks ... [et al.] --ch. 14.Metal-enhanced fluorescence : application to high-throughput screening and drug discovery /Kadir Aslan ... [et al.] --ch. 15.Methods for the design and analysis of replicate-experiment studies to establish assay reproducibility and the equivalence of two potency assays /Brian J. Eastwood ... [et al.] --ch. 16.Coupled luminescent methods in drug discovery : 3-minute assays for cytotoxicity and phosphatase activity /Michael J. Corey and Robert J. Kinders --ch. 17.Design and pharmaceutical applications of prodrugs /Tomi Järvinen ... [et al.] --ch. 18.GABA and glutamate receptor ligands and their therapeutic potential in CNS disorders /Ulf Madsen ... [et al.] --ch. 19.Cardiac sarcolemmal ATP-sensitive potassium channel antagonists : novel ischemia-selective antiarrhythmic agents /George E. Billman --ch. 20.Factors influencing the efficacy of mediator-specific anti-inflammatory, glucocorticoid, and anticoagulant therapies for sepsis /Peter C. Minneci ... [et al.] --ch. 21.Combinatorial chemistry in the drug discovery process /Nathan T. Ross, Brian R. McNaughton, and Benjamin L. Miller --ch. 22.Herbal medicines and animal models of gastrointestinal diseases /C.H. Cho and J.K.S. Ko --ch. 23.Endocrine and metabolic agents /Brian L. Furman --ch. 24.Respiratory viruses /Paul D. Olivo --ch. 25.Strategies in the design of antiviral drugs /Erik De Clercq and Piet Herdewijn --ch. 26.Protein kinase inhibitors in drug discovery /Keykavous Parang and Gongqin Sun --ch. 27.RNA-based therapies /Steve Pascolo --ch. 28.Novel imaging agents for molecular MR imaging of cancer /Dmitri Artemov and Zaver M. Bhujwalla --ch. 29.Targets and approaches for cancer drug discovery /Susan L. Mooberry.

Presents alphabetically arranged entries of drug products providing information on brand names, usage, dosage, pregnancy considerations, warnings, adverse reactions, and drug interactions.

Guide to the guide -- Drug identification : variations in drug nomenclature and their impact on information retrieval -- Government regulations affecting drugs and the pharmaceutical industry -- Evaluating drug information sources and developing a search protocol -- Pharmacology and therapeutics reference sources -- Reference sources for adverse drug reactions and interactions -- Drug analysis, formulation, and compounding reference sources -- Compiling background bibliography using online resources -- Competitive intelligence resources : drugs-in-development directories, protocol registries, and pharmaceutical business intelligence : companies, products, and marketplace research sources.

Introduction to Drug-Drug Interactions -- Mechanisms of Drug Interactions I: Absorption, Metabolism, and Excretion -- Mechanisms of Drug Interactions II: Transport Proteins -- Drug-Food Interactions -- Interactions Between Herbs and Antiinfective Medications -- Drug-Cytokine Interactions -- Beta-Lactam Antibiotics -- Macrolides, Azalides, and Ketolides -- Quinolones -- Glycopeptides, Lipopeptides, and Lipoglycopeptides -- Miscellaneous Antibiotics -- Drugs for Tuberculosis -- Drug Interactions with Antiretrovirals for HIV Infection -- Non-HIV Antiviral Agents -- Antifungal Agents -- Antimalarial Agents -- Antiprotozoal and Anthelmintic Agents -- Drug Interaction Considerations Throughout Drug Development -- Probe Cocktail Studies -- Design and Data Analysis in Drug Interaction Studies.

Cell Biology of Prostate Cancer and Molecular Targets / Martin E. Gleave, Michael E. Cox, and Yuzhuo Wang -- Part I. Hormone Therapy. Luteinizing Hormone-Releasing Hormone and its Agonistic, Antagonistic, and Targeted Cytotoxic Analogs in Prostate Cancer / Andrew V. Schally and Norman L. Block ; Nuclear Receptor Coregulators: Promising Therapeutic Targets for the Treatment of Prostate Cancer / Hannelore V. Heemers and Donald J. Tindall ; Androgens and Prostate Cancer / Douglas K. Price and Ann W. Hsing ; Androgen Receptor Biology in Prostate Cancer / Edward P. Gelmann ; Androgen Receptor Antagonists / Howard C. Shen, Mary-Ellen Taplin, and Steven P. Balk ; 5-Alpha Reductase Inhibitors in Prostate Cancer / Zoran Culig ; Adrenal Androgen Synthesis Inhibitor Therapies in Castration-Resistant Prostate Cancer / Terence W. Friedlander and Charles J. Ryan ; Androgen Deprivation Therapy / Nima Sharifi ; Pharmacogenetics of the Androgen Metabolic Pathway / Francine Zanchetta Coelho Marques, and Juergen K.V. Reichardt -- Part II. Chemotherapy. Mitoxantrone / Patricia Halterman, Nicholas J. Vogelzang, Alireza Farabishahadel, and Oscar B. Goodman Jr. ; Docetaxel / Courtney K. Phillips and Daniel P. Petrylak ; Beyond Docetaxel: Emerging Agents in the Treatment of Advanced Prostate Cancer / Jonathan Rosenberg ; Platinum Agents in Prostate Cancer / Ashley Brick, Junyang Niu, Jiaoti Huang, and William K. Oh ; Clinical Pharmacology and Pharmacogenetics of Chemotherapy in Prostate Cancer / Tristan M. Sissung and William D. Figg ; Microtubule Targeting Agents / Antonio Tito Fojo and David E. Adelberg -- Part III. Angiogenesis. Principles of Antiangiogenic Therapy / Cindy H. Chau and William D. Figg ; Bevacizumab in Advanced Prostate Cancer / Aymen A. Elfiky and William Kevin Kelly ; Thalidomide and Analogs / Erin R. Gardner, Giuseppe Di Lorenzo, and William D. Figg ; Investigational Angiogenesis Inhibitors / Jeanny B. Aragon-Ching and William Dahut ; Pharmacogenetics of Angiogenesis / Guido Bocci, Giuseppe Pasqualetti, Antonello Di Paolo, Francesco Crea, Mario Del Tacca, and Romano Danesi -- Part IV. Bone Metastasis. Pathophysiology of Prostate Cancer Bone Metastasis / Evan T. Keller and Christopher L. Hall ; Radiopharmaceuticals / Oliver Sartor and Damerla R. Venugopal ; Bisphosphonates for Prevention and Treatment of Bone Metastases / Philip J. Saylor and Matthew R. Smith ; Endothelin Receptors as Therapeutic Targets in Castration-Resistant Prostate Cancer / Joel B. Nelson ; Calcitriol and Vitamin D Analogs / Ana R. Jensen, Russell Z. Szmulewitz, Tomasz M. Beer, and Edwin M. Posadas -- Part V. Immunotherapy. Cancer Immunology, Immunotherapeutics, and Vaccine Approaches / Ravi A. Madan, James L. Gulley, Jackie Celestin, Philip M. Arlen, and Jeffrey Schlom ; Sipuleucel-T (APC8015): Active Cellular Immunotherapy for Advanced Metastatic Castration-Resistant Prostate Cancer / Celestia S. Higano and Mark W. Frohlich ; GM-CSF Gene-Transduced Prostate Cancer Vaccines: GVAX / Lalit R. Patel and Jonathan W. Simons ; CTLA-4 Blockade for Prostate Cancer Treatment / Andrea L. Harzstark and Lawrence Fong -- Part VI. Prevention. Prostate Cancer Chemoprevention Strategies / Howard L. Parnes, Margaret G. House, and Joseph A. Tangrea ; Diet and Prostate Cancer Incidence, Recurrence, and Progression Risk / June M. Chan and Erin L. Richman ; Inflammation as a Target in Prostate Cancer / Marshall Scott Lucia, James R. Lambert, Elizabeth A. Platz, and Angelo M. De Marzo -- Part VII. Drug Development. Challenges for the Development of New Agents in Prostate Cancer / Ajjai S. Alva, Deborah A. Bradley, and Maha Hussain ; FDA Approval of Prostate Cancer Treatments / Yang-Min Ning, Ramzi N. Dagher, and Richard Pazdur ; Applications of Proteomics in Prostate Cancer / Mitchell Gross, Edward Macrohon Nepomuceno, and David B. Agus.

Renal cytochrome P450s and flavin-containing monooxygenases : potential roles in metabolism and toxicity of 1,3-butadiene, trichloroethylene, and tetrachloroethylene / Adnan A. Elfarra -- Experimental approaches for the study of cytochrome P450 gene regulation / Hollie I. Swanson ... [et al.] -- Insulin and growth factor signaling : effects on drug metabolizing enzymes / Sang K. Kim, Kimberly J. Woodcroft, and Raymond F. Novak -- Catalytic function and expression of glutathione transferase zeta / Philip G. Board, M.W. Anders, and Anneke C. Blackburn -- Glucuronidation of fatty acids and prostaglandins by human udp glucuronosyltransferases / Anna Radominska-Pandya, Joanne M. Little and Arthur Bull -- Transcriptional regulation of UDP-glucuronosyltransferases / Anna Radominska-Pandya, Peter I. Mackenzie, and Wen Xie -- Phenotypic and genotypic characterization of n-acetylation / Craig K. Svensson and David W. Hein -- Methods and approaches to study metabolism and toxicity of acetaminophen / Sam A. Bruschi -- Modulation of drug metabolism and antiviral therapies / Bernhard H. Lauterburg -- Modulation of thiols and other low-molecular-weight cofactors : effects on drug metabolism and disease susceptibility / Charles V. Smith -- Multidrug resistance proteins and hepatic transport of endo- and xenobiotics / Phillip M. Gerk and Mary Vore -- Structural determinants of folate and antifolate membrane transport by the reduced folate carrier / Wei Cao and Larry H. Matherly -- Glutathione transport in the kidneys : experimental models, mechanisms, and methods / Lawrence H. Lash -- Human cytosolic sulfotransferases : properties, physiological functions, and toxicology / Charles N. Falany.

Multidrug Resistance Mediated by MDR-ABC Transporters / Gergely Szakács ... [et al.] -- Metastasis and Drug Resistance / Dominic Fan ... [et al.] -- The Role of Autophagy and Apoptosis in the Drug Resistance of Cancer / Tomohisa Yokoyama ... [et al.] -- Mechanisms of Resistance to targeted Tyrosine Kinase Inhibitors / Stacey J.Baker, E. Premkumar Reddy -- Targeting Transglutaminase-2 to overcome Chemoresistance in Cancer Cells / Kapil Mehta, Jansina Y. Fok -- Extracellular Matrix-Mediated Drug Resistance / P.S. Hodkinson, Tariq Sethi -- Oxidative Stress and Drug Resistance in Cancer / Dunyaporn Trachootham, Wan Zhang, Peng Huang -- Nuclear Factor-kB and Chemoresistance / Ajaikumar B.Kunnumakkara, Preetha Anand, Bharat B. Aggarwal -- Drug Resistance and the Tumor Suppressor p53 : The Paradox of Wild-Type Genotype in Chemorefractory Cancers / Zahid H. Siddik -- Resistance to Differentiation Therapy / Bulent Ozpolat -- MicroRNAs and Drug Resistance / Elisa Barbarotto, George A. Calin -- Molecular Signatures of Drug Resistance / Melissa A. Troester, Jason I. Herschkowitz, Katherine A. Hoadley -- Assessment of Drug Resistance in Anticancer Therapy by Nuclear Imaging / Natalie Charnley, Catharine West, Pat Price -- Overcoming Drug Resistance by Phytochemicals / Marion M. Chan, Dunne Fong.

Developing Combination Drugs in Preclinical Studies / Alberto Lodola -- Preclinical Evaluation of Juvenile Toxicity / Paul C. Barrow, Stéphane Barbellion, Jeanne Stadler -- Necropsy and Sampling Procedures in Rodents / Laurence Fiette, Mohamed Slaoui -- Histopathology Procedures: From Tissue Sampling to Histopathological Evaluation / Mohamed Slaoui, Laurence Fiette -- Principles and Methods of Immunohistochemistry / José A. Ramos-Vara -- Tissue Microarrays and Digital Image Analysis / Denise Ryan, Laoighse Mulrane, Elton Rexhepaj, William M. Gallagher -- Micronucleus Assay and Labeling of Centromeres with FISH Technique / Ilse Decordier, Raluca Mateuca, Micheline Kirsch-Volders -- The Use of Bacterial Repair Endonucleases in the Comet Assay / Andrew R. Collins -- Manual Whole-Cell Patch-Clamping of the HERG Cardiac K+ Channel / Xiao-Liang Chen, Jiesheng Kang, David Rampe -- Generation and Analysis of Transcriptomics Data / Philip D. Glaves, Jonathan D. Tugwood -- Protocols of Two-Dimensional Difference Gel Electrophoresis to Investigate Mechanisms of Toxicity / Emmanuelle Com, Albrecht Gruhler, Martine Courcol, Jean-Charles Gautier -- Protocols and Applications of Cellular Metabolomics in Safety Studies Using Precision-Cut Tissue Slices and Carbon 13 NMR / Gabriel Baverel, Sophie Renault, Hassan Faiz, Maha Hage, Catherine Gauthier, Agnès Duplany, Bernard Ferrier, Guy Martin -- Statistical Analysis of Quantitative RT-PCR Results / Richard Khan-Malek, Ying Wang -- Evaluation of Mitochondrial Respiration in Cultured Rat Hepatocytes / Jean-Pierre Marchandeau, Gilles Labbe -- FETAX Assay for Evaluation of Developmental Toxicity / Isabelle Mouche, Laure Malesic, Olivier Gillardeaux -- Evaluation of Embryotoxicity Using the Zebrafish Model / Lisa Truong, Stacey L. Harper, Robert L. Tanguay -- Protocols of In Vitro Protein Covalent Binding Studies in Liver / Jean-François Lévesque, Stephen H. Day, Allen N. Jones -- Utilization of MALDI-TOF to Determine Chemical-Protein Adduct Formation In Vitro / Ashley A. Fisher, Matthew T. Labenski, Terrence J. Monks, Serrine S. Lau -- Utilization of LC-MS/MS Analyses to Identify Site-Specific Chemical Protein Adducts In Vitro / Ashley A. Fisher, Matthew T. Labenski, Terrence J. Monks, Serrine S. Lau / One-Dimensional Western Blotting Coupled to LC-MS/MS Analysis to Identify Chemical-Adducted Proteins in Rat Urine / Matthew T. Labenski, Ashley A. Fisher, Terrence J. Monks, Serrine S. Lau -- Identification of Chemical-Adducted Proteins in Urine by Multi-dimensional Protein Identification Technology (LC/LC-MS/MS) / Matthew T. Labenski, Ashley A. Fisher, Terrence J. Monks, Serrine S. Lau -- Optimization of SELDI for Biomarker Detection in Plasma / Jean-Francois Léonard, Martine Courcol, Jean-Charles Gautier -- Differential Proteomics Incorporating iTRAQ Labeling and Multi-dimensional Separations / Ben C. Collins, Thomas Y. Lau, Stephen R. Pennington, William M. Gallagher -- NMR and MS Methods for Metabonomics / Frank Dieterle, Björn Riefke, Götz Schlotterbeck, Alfred Ross, Hans Senn, Alexander Amberg -- Absolute Quantification of Toxicological Biomarkers by Multiple Reaction Monitoring / Thomas Y. Lau, Ben C. Collins, Peter Stone, Ning Tang, William M. Gallagher, Stephen R. Pennington.

Arsenite resistance in leishmania and possible drug targets / Gaganmeet Singh, K.G. Jayanarayan, Chinmoy S. Dey -- Unique characteristics of the kinetoplast DNA replication machinery provide potential drug targets in trypanosomatids / Dotan Sela ... [et al.] -- Drugs and transporters in kinetoplastid protozoa / Scott M. Landfear -- Selective lead compounds against kinetoplastid tubulin / R.E. Morgan and K.A. Werbovetz -- Fishing for anti-leishmania drugs: principles and problems / Emanuela Handman ... [et al.] -- Sterol 14-demethylase inhibitors for trypanosoma cruzi infections / Frederick S. Buckner -- Histone deacetylases / David Horn -- Targeting glycoproteins or glycolipids and their metabolic pathways for antiparasite therapy / Sumi Mukhopadhyay nee Bandyopadhyay and Chitra Mandal -- DNA topoisomerases of leishmania: the potential targets for anti-leishmanial therapy / Benu Brata Das, Agneyo Ganguly and Hemanta K. Majumder -- Antiparasitic chemotherapy: tinkering with the purine salvage pathway / Alok Kumar Datta, Rupak Datta and Banibrata Sen -- Searching the tritryp genomes for drug targets / Peter J. Myler -- Purine and pyrimidine metabolism in leishmania / Nicola S. Carter ... [et al.].

Biophysical approaches -- Chemical and molecular biological approaches -- Enzymology and biological approaches.

I. Chapters of general nature. How to handle biological specimens -- Alternative specimens -- Pitfalls and cautions in analysis of drugs and poisons -- Pretreatments of human specimens -- Detection methods -- A computer system for diagnosis of causative drugs and poisons developed by the Japan Poison Information Center (Tokyo) -- Practical use of the poison-net developed by the Japan Poison Information Network (Hiroshima) -- Problems in toxin analysis in emergency medicine -- Analyses of chemical warefare agents and their related compounds -- B. Chapters on specific toxins. Volatile compounds -- Controlled drugs -- Psychopharmaceuticals and hypnotics -- General drugs -- Chemicals of daily necessaries -- Natural toxins and alkaloids -- Pesticides -- Miscellaneous.

Male sexual health -- Structure and physiology of the testis -- Introduction -- The spermatozoa -- Sperm motility -- Capacitation and acrosome reaction -- Fertilization of the oocyte -- Testing substances that compromise spermatogenesis and fertility (adapted from Creasy 1997) -- Testosterone production and testosterone effects -- Physiology of erection -- Introduction -- Role of androgens in erection -- Priapism -- Physiology of ejaculation -- Drugs which compromise male sexual health -- Adverse drug effects -- Male sexual health and drugs -- Drugs which compromise testicular function -- Drugs which compromise erectile function -- Drugs which compromise ejaculation -- Database of drugs.

"Every year the average number of prescriptions purchased by Americans increases, as do healthcare expenditures, which are projected to reach one fifth of the U.S. gross domestic product by 2020. In Drugs for Life, Joseph Dumit considers how our burgeoning consumption of medicine and cost of healthcare not only came to be, but came to be taken for granted. For several years, Dumit attended pharmaceutical industry conferences; spoke with marketers, researchers, doctors, and patients; and surveyed the industry's literature regarding strategies to expand markets for prescription drugs. He concluded that underlying the continual growth in medications, disease categories, costs, and insecurity is a relatively new perception of ourselves as inherently ill and in need of chronic treatment. This perception is based on clinical trials that we have largely outsourced to pharmaceutical companies. Those companies in turn see clinical trials as investments and measure the value of those investments by the size of the market they will create. They only ask questions for which the answer is more medicine. Drugs for Life challenges our understanding of health, risks, facts, and clinical trials, the very concepts used by pharmaceutical companies to grow markets to the point where almost no one can imagine a life without prescription drugs."--Provided by publisher.

[Beta]-blocking agents / Lionel H. Opie, John D. Horowitz -- Nitrates and newer antianginals / Lionel H. Opie, John D. Horowitz -- Calcium channel blockers (calcium antagonists) / Lionel H. Opie -- Diuretics / Lionel H. Opie, Norman M. Kaplan -- Inhibitors of angiotensin-converting enzyme, angiotensin II receptor, aldosterone, and renin / Lionel H. Opie, Marc A. Pfeffer -- Acute and chronic heart failure : positive inotropes, vasodilators, and digoxin / Philip A. Poole-Wilson, Lionel H. Opie -- Antihypertensive drugs / Norman M. Kaplan, Lionel H. Opie -- Antiarrhythmic drugs and strategies / Lionel H. Opie, John P. DiMarco, Bernard J. Gersh -- Antithrombotic agents : platelet inhibitors, anticoagulants, and fibrinolytics / Keith A.A. Fox ... [et al.] -- Lipid-modifying and antiatherosclerotic drugs / Antonio M. Gotto, Jr., Lionel H. Opie -- Metabolic syndrome, hyperglycemia, and Type 2 diabetes / Lionel H. Opie, John M. Miles, Sidney C. Smith, Jr. -- Which therapy for which conditon? / Bernard J. Gersh, Lionel H. Opie.

Anatomy and physiology of the ocular surface / Athiya Agarwal -- Lacrimal system: anatomy and physiology / Alexander V. On and Marc J. Hirschbein -- Anatomy, physiology, and biochemistry of the tear film / Ashok Garg, Amar Agarwal, and C. Sujatha -- Dry eye process and ocular surface disorders / Soosan Jacob and Amar Agarwal -- Evaluation of the dry eye patient / Grant D. Gilliland -- Dry eye secondary to aqueous tear deficiency (Sjögren's syndrome) / Mahmoud M. Ismail, M. Alaa El Danasoury, and Akef El Maghrabi -- Dry eye secondary to increased evaporation / Amar Agarwal and Soosan Jacob -- Allergy- and medication-induced ocular surface disease / W. Barry Lee and Ivan R. Schwab -- Chemical burns and the dry eye / Vatinee Y. Bunya, Christopher J. Rapuano, and Kristin M. Hammersmith --Keratoplasty: ocular surface corneal transplantation / Roy S. Chuck ... [et al.] -- Keratolimbal allografting / Daniel Böhringer, Rainer Sundmacher and Thomas Reinhard -- Keratoprosthesis / M. Emilia Mulet and Jorge L. Alio -- Surgical options for dry eyes and exacerbating eyelid disorders / Kimberly Cockerham, Orin Zwick, and Glenn C. Cockerham -- Contact lens-induced dry eye / Kenneth Daniels -- Cataract surgery in the dry eye patient / Suresh K. Pandey, Brighu Swamy, and Amar Agarwal -- Refractive surgery and the dry eye patient / Ahmad M. Fahmy and David R. Hardten -- Computer vision syndrome / Suresh K. Pandey and Brighu Swamy.Ocular cicatricial pemphigoid and dry eye syndrome / Vasudha Panday, Kristin M. Hammersmith, and Christopher J. Rapuano -- Tear supplements-artificial tears / Guillermo L. Simón-Castellví ... [et al.] -- Autologous serum drops / Kazuo Tsubota and Murat Dogru -- Restasis-topical cyclosporin A / Renée Solomon ... [et al.] -- Management: miscellaneous modalities / Soosan Jacob ...[et al.] -- Punctal occlusion: plugs, cautery, and suturing / Sanjay V. Patel and H. Kaz Soong -- Amniotic membrane transplantation / Oscar Gris and José L. Güell -- Limbal stem cell disease and management / W. Barry Lee and Ivan R. Schwab --Surgical procedure in stem cell transplantation / Sunita Agarwal and Soosan Jacob -- Large diameter lamellar keratoplasty and stem cell transplantation / Javier Mendicute ... [et al.] --

Etiological theories on the relationship of mental disorders and substance use disorders / Moggi, F. -- The genetic basis of substance use and abuse / Jacobson, K.C. -- Paths of genetic and environmental influence: the routes connecting personality disorders with substance use disorders / Cadoret, R.J. ... [et al.] -- Historical and conceptual issues / Jacobs, W.S., Cahill, K.S., Gold, M.S. -- Comorbidity in alcohol use disorders: focus on mood, anxiety and personality / Hintz, T., Mann, K. -- Having attention-deficit/hyperactivity disorder and substance use disorder: a review of the literature / Eich, D., Figner, B. -- Diagnostic issues in dual diagnosis patients / Petitjean, S. -- Neurocognitive impairment: an underdiagnosed comorbid entity in the treatment of substance use disorders / Dorsteler-MacFarland, K.M., Cereghetti, K.H., Wiesbeck, G.A. -- Modified therapeutic communities for co-occurring substance abuse and psychiatric disorders / Leon, G.D.

Duane's Clinical ophthalmolgy -- Duane's Foundations of clinical ophthalmology -- New and revised chapters: Duane's Clinical ophthalmolgy -- New and revised chapters: Duane's Foundations of clinical ophthalmology.

Duane's Clinical ophthalmolgy -- Duane's Foundations of clinical ophthalmology -- New and Revised Chapters: Duane's Clinical Ophthalmology -- New and Revised Chapters: Duane's Foundations of Clinical Ophthalmology.

Acknowledgments -- Introduction -- Author -- Bibliographic abbreviations -- Chemical and medical abbreviations -- Hushpuppy -- Format of this book -- Catalog of "faith-based" farmaceuticals -- References -- Common name index -- Scientific name index.

Assessing infants and toddlers -- Assessing the preschool-age child -- Assessing the elementary school-age child -- Assessing adolescents -- Classification of psychiatric disorders -- The process of assessment and diagnosis -- Diagnostic interviews -- Rating scales -- Pediatric evaluation and laboratory testing -- Neurological examination, electroencephalography, and neuroimaging -- Psychological and neuropsychological testing -- Intellectual disability (mental retardation) -- Autism spectrum disorders -- Developmental disorders of learning, communication, and motor skills -- Attention-deficity/hyperactivity disorder -- Oppositional defiant disorder and conduct disorder -- Substance abuse and addictions -- Depression and dysthmyia -- Biopolar disorder -- Generalized anxiety disorder, specific phobia, panic disorder, social phobia, and selective mutism -- Separation anxiety disorder and school refusal -- Posttraumatic stress disorder -- Obsessive-compulsive disorder -- Early-onset schizophrenia -- Obesity -- Anorexia nervosa and bulimia nervosa -- Tic disorders -- Elimination disorders -- Sleep disorders -- Evidence-based practices -- Child abuse and neglect -- HIV and AIDS -- Bereavement and traumatic grief -- Ethnic, cultural, and religious issues -- Youth suicide - Gender identity and sexual orientation -- Aggression and violence -- Genetics: fundamentals relevant to child and adolescent psychiatry -- Psychiatric emergencies -- Family transitions: challenges and resilience -- Psychiatric aspects of chronic physical disorders -- Children of parents with psychiatric and substance abuse disorders -- Legal and ethical issues --; Telepsychiatry -- Principles of psychopharmacology -- Medications used for attention-deficit/hyperactivity disorder -- Antidepressants -- Mood stabilizers -- Antipsychotic medications -- Apha-adrenergics, beta-blockers, benzodiazepines, buspirone, and desmopressin - Medications used for sleep -- Electroconvulsive therapy, transcranial magnetic stimulation, and deep brain stimulation -- Individual psychotherapy -- Parent counseling, psychoeducation, and parent support groups -- Behavioral parent training --- Family therapy - Interpersonal psychotherapy for depressed adolescents -- Cognitive-behavioral treatment for anxiety disorders -- Cognitive-behavioral therapy for depression - Motivational interviewing -- System of care, wraparound services,and home-based services -- Milieu treatment: inpatient, partial hospitalization, and residential programs -- School-based interventions -- Collaborating with primary care -- Juvenile justice.

Introduction -- Historical considerations -- Anatomy of the cavernous sinus and related structures -- Classification of cavernous sinus fistulas (CSFs) and dural arteriovenous fistulas (DAVFs) -- Etiology, prevalence and natural history of dural cavernous sinus fistulas (DCSFs) -- Neuro-ophthalmology in dural cavernous sinus fistulas (DCSFs) -- Radiological diagnosis of DCSFs -- Endovascular treatment -- Alternative treatment options -- Hemodynamic aspects of DCSFs -- Summary.

"The purpose of Dust Mites is to provide a comprehensive reference work for all readers with an involvement or interest in house dust mite research and management, incorporating ... the topics of systematics and identification, physiology, ecology, allergen biochemistry and molecular biology, epidemiology, mite control and allergen avoidance."--From publisher's notes.

Elements of the nervous system -- Somatosensory system -- Motor system -- Brainstem -- Cerebellum -- Diencephalon and autonomic nervous system -- Limbic system -- Basal ganglia -- Cerebrum -- Coverings of the brain and spinal cord: cerebrospinal fluid and ventricular system -- Blood supply and vascular disorders of the central nervous system.

Dynamic imaging of brain function / Fahmeed Hyder -- Fractal characterization of complexity in dynamic signals : application to cerebral hemodynamics / Peter Herman, Laszlo Kocsis, and Andras Eke -- Wide-field and two-photon imaging of brain activity with voltage- and calcium-sensitive dyes / Ryota Homma ... [et al.] -- Two-photon imaging of capillary blood flow in olfactory bulb glomeruli / Pascale Tiret ... [et al.] -- Astrocytic calcium signaling : mechanism and implications for functional brain imaging / Xiaohai Wang, Takahiro Takano, and Maiken Nedergaard -- Using the light scattering component of optical intrinsic signals to visualize in vivo functional structures of neural tissues / Uma Maheswari Rajagopalan, Kazushige Tsunoda, and Manabu Tanifuji -- Methods for studying functional interactions among neuronal populations / Nandakumar S. Narayanan and Mark Laubach -- Magnetoencephalography (MEG) / Andreas A. Ioannides -- Functiional neuroimaging of spike-wave seizures / Joshua E. Motelow and Hal Blumenfeld -- Tactile and non-tactile sensory paradigms for fMRI and neurophysiologic studies in rodents / Basavaraju G. Sanganahalli ... [et al.] -- Using fMRI for elucidating dynamic interactions / Yul-Wan Sung and Seiji Ogawa -- Resting-state functional connectivity in animal models : modulations by exsanguination / Bharat B. Biswal and Sridhar S. Kannurpatti -- Dynamic magnetic resonance imaging of cerebral blood flow using arterial spin labeling / Afonso C. Silva and Fernando F. Paiva -- Dynamic MRI of small electrical activity / Allen W. Song, Trong-Kha Truong, Marty Woldorff -- Advanced in vivo heteronuclear MRS approaches for studying brain bioenergetics driven by mitochondria / Xiao-Hong Zhu ... [et al.]

The why and how of dynamic modeling -- Basic epidemic models -- Insect dynamics -- Malaria and sickle cell anemia -- Encephalitis -- Chagas disease -- Lyme disease -- Chicken pox and shingles -- Toxoplasmosis -- The zebra mussel -- Biological control of pestilence -- Indirect susceptible-infected-resistant models of arboviral encephalitis transmission -- Chaos and pestilence -- Catastrophe and pestilence -- Spatial pestilence dynamics.

Basic models -- Chemostat versus the lake -- Instability tendencies -- Self-regulation -- Wall growth -- Zones of no activation -- Influence of the control mechanisms -- Parameter estimation using dynamic optimization.

"In the last twenty years, dynamic prediction models have been extensively used to monitor patient prognosis in survival analysis. Written by one of the pioneers in the area, this book synthesizes these developments in a unified framework. It covers a range of models, including prognostic and dynamic prediction of survival using genomic data and time-dependent information. The text includes numerous examples using real data that is taken from the authors collaborative research. R programs are provided for implementing the methods"--Provided by publisher.

Methods for uncovering the mechanisms of AMPA receptor trafficking / Sophie Restituito and Edward B. Ziff -- Long-term plasticity at inhibitory synapses: a phenomenon that has been overlooked / Jean-Luc Gaiarsa and Yehezkel Ben-Ari -- New tricks for an old dog: proteomics of the PSD / Bryen A. Jordan ... [et al.] -- Phosphorylation site-specific antibodies as research tools in studies of native GABA[subscript A] receptors / Jasmina Jovanovic -- Protein palmitoylation by DHHC protein family / Yuko Fukata, David S. Bredt, Masaki Fukata --RNAi and applications in neurobiology / Tija C. Jacob -- Transfecting and transducing neurons with synthetic nucleic acids and biologically active macromolecules / Josef T. Kittler, Jonathan G. Hanley, John T.R. Isaac -- Acute in vivo expression of recombinant proteins in rat brain using Sindbis virus / Hélène Marie & Robert C. Malenka -- Lentivirus-based genetic manipulations in neurons in vivo / Pavel Osten, Tanjew Dittgen, and Pawel Licznerski -- AMPA receptor phosphorylation in synaptic plasticity : insights from knockin mice / Hey-Kyoung Lee -- Genomic and post-genomic tools for studying synapse biology / Josef T. Kittler and Peter L. Oliver.Studying the localization, surface stability and endocytosis of neurotransmitter receptors by antibody labelling and biotinylation approaches / I. Lorena Arancibia-Cárcamo ... [et al.] -- Visualisation of AMPAR trafficking and surface expression / Pavel V. Perestenko and Jeremy M. Henley -- Neurotransmitter dynamics / Sabine Lévi and Antoine Triller -- Receptor dynamics at the cell surface studied using functional tagging / Philip Thomas and Trevor G. Smart --

Structure, biosynthesis and gene regulation of collagens in cartilage and bone / Klaus von der Mark -- Fibrillogenesis and maturation of collagens / Simon P. Robins -- Vitamin K dependent proteins of bone and cartilage / Caren M. Gundberg and Satoru K. Nishimoto -- Noncollagenous proteins: glycoproteins and related proteins / Dick Heinegård, Pilar Lorenzo, and Tore Saxne -- Proteoglycans and glycosaminoglycans / Tim Hardingham -- Growth factors / Philippa Hulley, Graham Russell, and Peter Croucher -- Prostaglandins and proinflammatory cytokines / Lawrence G. Raisz and Joseph A. Lorenzo -- Integrins and other adhesion molecules / M.H. Helfrich and M.A. Horton -- Alkaline phosphatases / José Luis Millán -- Acid phosphatases / Helena Kaija ... [et al.] -- Matrix proteinases / Ian M. Clark and Gillian Murphy -- Mineralization, structure and function of bone / Adele L. Boskey -- Bone structure and strength / Ego Seeman -- The cells of bone / Jane B. Lian and Gary S. Stein -- Signaling in bone / T. John Martin and Natalie A. Sims -- Parathyroid hormone: structure, function and dynamic actions / Lorraine A. Fitzpatrick and John P. Bilezikian -- Interaction of parathyroid hormone-related peptide with the skeleton / David Goltzman -- The vitamin D hormone and its nuclear receptor: mechanisms involved in bone biology / Geert Carmeliet ... [et al.] -- Sex steroid effects on bone metabolism / David G. Monroe, Thomas C. Spelsberg, and S. Khosla -- Physiology of calcium and phosphate homeostasis / René Rizzoli and Jean-Philippe Bonjour -- The central control of bone remodelling / Paul A. Baldock ... [et al.] -- New concepts in bone remodeling / David W. Dempster and Hua Zhou -- Products of bone collagen metabolism / Juha Risteli and Leila Risteli -- Supramolecular structure of cartilage matrix / Peter Bruckner -- Products of cartilage metabolism / Daniel-Henri Manicourt, Jean-Pierre Devogelaer, and Eugene J.-M.A. Thonar -- Fluid dynamics of the joint space and trafficking of matrix products / Peter A. Simkin --Transgenic models of bone disease / Barbara E. Kream and John R. Harrison -- The role of genetic variation in osteoporosis / André G. Uitterlinden ... [et al.] -- Measurement of calcium, phosphate and magnesium / Heinrich Schmidt-Gayk -- Measurement of parathyroid hormone / Harald Jüppner and Ghada El-Hajj Fuleihan -- New horizons for assessment of vitamin D status in man / Gary L. Lensmeyer, Neil Binkley, and Marc K. Drezner -- Measurement of biochemical markers of bone formation / Kim E. Naylor and Richard Eastell -- Measurement of biochemical markers of bone resorption / Marius E. Kraenzlin and Markus J. Seibel -- Variability in the measurement of biochemical markers of bone turnover / Tuan V. Nguyen, Christian Meier, and Markus J. Seibel -- Validation of biochemical markers of bone turnover / Kim Brixen and Erik Fink Eriksen -- Genetic markers of joint disease / Michel Neidhart, Renate E. Gay, and Steffen Gay -- Laboratory assessment of postmenopausal osteoporosis / Patrick Garnero and Pierre D. Delmas -- Monitoring anabolic treatment / John P. Bilezikian and Mishaela R. Rubin -- Monitoring of antiresorptive therapy / Christian Meier, Tuan V. Ngyen, and Markus J. Seibel -- Age-related osteoporosis and skeletal markers of bone turnover / Clifford J. Rosen -- Steroid-induced osteoporosis / Ian R. Reid -- Transplantation osteoporosis: biochemical correlates of pathogenesis and treatment / Carolina A. Moreira Kulak and Elizabeth Shane -- Secondary osteoporosis / Jean E. Mulder, Carolina A. Moreira Kulak, and Elizabeth Shane -- Osteomalacia and rickets / Marc K. Drezner -- Assessment of bone and joint diseases: renal osteodystrophy / Esther A. González, Ziyad Al Aly, and Kevin J. Martin -- Primary hyperparathyroidism / Shonni J. Silverberg, and John P. Bilezikian -- Paget's disease of bone / Andreas Grauer, Ethel Siris, and Stuart Ralston -- Metastatic bone disease / Jean-Jacques Body -- Rare bone diseases / Michael P. Whyte -- Osteogenesis imperfecta / Francis H. Glorieux and Frank Rauch -- Rheumatoid arthritis and other inflammatory joint pathologies / Steven R. Goldring and Mary B. Goldring -- Osteoarthritis and degenerative spine pathologies / Kristina Åkesson.

Age of cancer incidence -- Multistage progression -- History of theories -- Progression dynamics -- Theory I -- Theory II -- Genetics of progression -- Carcinogens -- Aging -- Inheritance -- Stem cells : tissue renewal -- Stem cells : population genetics -- Cell lineage history.

Research on dyneins has a direct impact on human diseases, such as viruses and cancer. With an accompanying website showing over one hundred streaming videos of cell dynamic behavior for best comprehension of material, Dynein: Structure, Biology and Disease is the only reference covering the structure, biology and application of dynein research to human disease. From bench to bedside, Dynein: Structure, Biology and Disease offers research on fundamental cellular processes to researchers and clinicians across developmental biology, cell biology, molecular biology, biophysics, biomedicine, genetics and medicine. . Broad-based up-to-date resource for the dynein class of molecular motors . Chapters written by world experts in their topics . Numerous well-illustrated figures and tables included to complement the text, imparting comprehensive information on dynein composition, interactions, and other fundamental features.

Anatomy and Physiology /Olle Ekberg and Göran Nylander --Saliva and the Control of Its Secretion /Jörgen Ekström, Nina Khosravani, Massimo Castagnola and Irene Messana --Feeding and Respiration /Olle Ekberg, Anna I. Hårdemark Cedborg, Katarina Bodén, Hanne Witt Hedström and Richard Kuylenstierna, et al. --Oral and Pharyngeal Function and Dysfunction /Olle Ekberg --Evaluation of Symptoms /Doris-Maria Denk-Linnert --Neurology of Swallowing and Dysphagia /Mario Prosiegel --Gastroesophageal Reflux Disease, Globus, and Dysphagia /Jacqui Allen and Peter C. Belafsky --Pediatric Aspect of Dysphagia /Pascale Fichaux Bourin, Michèle Puech and Virginie Woisard --Dysphagia in Systemic Disease /Thomas Mandl and Olle Ekberg --The Geriatric Pharynx and Esophagus /Olle Ekberg --Voice and Dysphagia /Daniele Farneti --Psychiatric Aspects of Dysphagia /Margareta Bülow --The Clinical and Radiological Approach to Dysphagia /Peter Pokieser and Martina Scharitzer --Imaging Techniques and Some Principles of Interpretation (Including Radiation Physics) /Olle Ekberg --Pharyngeal Morphology /Stephen E. Rubesin --Morphology of the Esophagus /Marc S. Levine and Arastoo Vossough --The Pediatric Esophagus /Jane E. Benson --Pharyngeal Manometry /Rolf Olsson --Esophageal Manometry and Gastroesophageal Reflux Monitoring /Karin Aksglæde, Per Thommesen and Peter Funch-Jensen --Impedance Planimetry /Johannes Lenglinger --Radiologic Evaluation of Esophageal Function /Wolfgang Schima, Edith Eisenhuber and Christiane Kulinna-Cosentini --Neuroimaging in Patients with Dysphagia /Kasim Abul-Kasim --Cross-Sectional Imaging of the Oesophagus Using CT and PET/Techniques /Ahmed Ba-Ssalamah, Barbara J. Fueger and Wolfgang Schima --Endoscopy of the Pharynx and Esophagus /Doris-Maria Denk-Linnert and Rainer Schöfl --The Therapeutic Swallowing Study /Margareta Bülow and Bonnie Martin-Harris --Surgical Aspects of Pharyngeal Dysfunction, Dysphagia, and Aspiration /Hans F. Mahieu and Martijn P. Kos --The Post-Operative Pharynx and Larynx /Anita Wuttge-Hannig and Christian Hannig --Dysphagia Evaluation and Treatment After Head and Neck Surgery and/or Chemo-radiotherapy for Head and Neck Malignancies /Antonio Schindler, Francesco Mozzanica and Filippo Barbiera --Behavioural Treatment of Oropharyngeal Dysphagia: Bolus Modification and Management, Sensory and Motor Behavioural Techniques, Postural Adjustments, and Swallow Manoeuvres /Renée Speyer --Rheological Aspects of Swallowing and Dysphagia /Edmundo Brito-de la Fuente, Olle Ekberg and Críspulo Gallegos --The Dietitian's Role in Diagnosis and Treatment of Dysphagia /S. Burton, A. Laverty and M. Macleod --Direct and Indirect Therapy: Neurostimulation for the Treatment of Dysphagia After Stroke /Satish Mistry, Emilia Michou, Dipesh H. Vasant and Shaheen Hamdy --Intervention on the Esophagus /Jason D. Conway, David J. Ott and Michael Y. Chen --The Importance of Enteral Nutrition /Christina Stene and Bengt Jeppsson --Complications of Oropharyngeal Dysphagia: Malnutrition and Aspiration Pneumonia /Silvia Carrión, Eric Verin, Pere Clavé and Alessandro Laviano --Dehydration in Dysphagia /Zeno Stanga, Samuel Hannes Baldinger and Pere Clavé.