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  • 2012 Springer Protocols
    edited by Lotte Bjergbæk.
    DNA repair : front and center and not going away! / Vilhelm A. Bohr -- Identification of genes required for damage survival using a cell-based RNAi screen against the Drosophila genome / Dashnamoorthy Ravi and Alexander James Roy Bishop -- Isolating genes involved with genotoxic drug response in the nematode Caenorhabditis elegans using genome-wide RNAi screening / Lone Vedel Schøler [and others] -- Establishment of the DNA repair-defective mutants in DT40 cells / Masamichi Ishiai, Emi Uchida, and Minoru Takata -- Electrophoretic mobility shift assays for protein-DNA complexes involved in DNA repair / Chun Tsai [and others] -- Comet assay : a sensitive genotoxicity test for the detection of DNA damage and repair / Günter Speit and Andreas Rothfuss -- Detection of DNA damage by comet fluorescence in situ hybridization / Wiebke Schlörmann and Michael Glei -- Quantitative DNA damage and repair measurement with the yeast comet assay / Rui Oliveira and Björn Johansson -- Analysis of DNA damage and repair in nuclear and mitochondrial DNA of animal cells using quantitative PCR / Amy M. Furda [and others] -- In vitro DNA mismatch repair in human cells / Liya Gu, Charles M. Ensor, and Guo-Min Li -- Eukaryotic DNA mismatch repair in vitro / Fenghua Yuan [and others] -- Immuno-slot blot assay for detection of UVR-mediated DNA damage / Mahsa Karbaschi [and others] -- Quantification of DNA photoproducts in mammalian cell DNA using radioimmunoassay / Thomas R. Berton and David L. Mitchell -- Measuring the formation and repair of UV damage at the DNA sequence level by ligation-mediated PCR / Ahmad Besaratinia and Gerd P. Pfeifer -- Construction of plasmids containing site-specific DNA interstrand cross-links for biochemical and cell biological studies / Milica Enoiu [and others] -- Replication-coupled DNA interstrand cross-link repair in Xenopus egg extracts / Puck Knipscheer [and others] -- In vitro base excision repair using mammalian cell extracts / Jason L. Parsons and Grigory L. Dianov -- Using Arabidopsis cell extracts to monitor repair of DNA base damage in vitro / Dolores Córdoba-Cañero, Teresa Roldán-Arjona, and Rafael R. Ariza -- In vitro monitoring of base excision repair in Saccharomyces cerevisiae / Simone Moertl and Fred Ahne -- Mitochondrial base excision repair assays / Ricardo Gredilla and Tinna Stevnsner -- O-hydroxylamine-coupled alkaline gel electrophoresis assay for the detection and measurement of DNA single-strand breaks / April M. Luke and Jun Nakamura -- DNA double-strand break damage and repair assessed by pulsed-field gel electrophoresis / Helen E. Bryant -- Quantitative amplification of single-stranded DNA / Eva-Maria Holstein and David Lydall -- Simple, non-radioactive measurement of single-stranded DNA at telomeric, sub-telomeric, and genomic loci in budding yeast / James M. Dewar and David Lydall -- Monitoring DNA recombination initiated by HO endonuclease / Neal Sugawara and James E. Haber -- Monitoring I-SceI-induced double-strand break repair in DT40 Cells / David du Plessis and Julian E. Sale -- I-SceI-based assays to examine distinct repair outcomes of mammalian chromosomal double strand breaks / Amanda Gunn and Jeremy M. Stark -- Studying repair of a single protein-bound nick in vivo using the Flp-nick system / Ida Nielsen, Anni H. Andersen, and Lotte Bjergbæk -- Measurement of diversification in the immunoglobulin light chain gene of DT40 cells / Julian E. Sale -- Live cell microscopy of DNA damage response in Saccharomyces cerevisiae / Sonia Silva [and others] -- Use of gene targeting to study recombination in mammalian cell DNA repair mutants / Jennifer J. Rahn, Gerald M. Adair, and Rodney S. Nairn -- In vitro rejoining of double strand breaks in genomic DNA / George Iliakis, Emil Mladenov, and Nge Cheong -- In vitro DNA double-strand break repair assay based on end-joining of defined duplex oligonucleotides / Kamal Datta [and others] -- Assays of bypass replication of genotoxic lesions in cell-free extracts / Nana Nikolaishvili-Feinberg and Marila Cordeiro-Stone -- Quantitative measurement of translesion DNA synthesis in mammalian cells / Omer Ziv [and others] -- Detection of PCNA modifications in Saccharomyces cerevisiae / Adelina A. Davies and Helle D. Ulrich -- In vitro PCNA modification assays / Joanne L. Parker and Helle D. Ulrich -- Analysis of inhibition of DNA replication in irradiated cells using the SV40 based in vitro assay of DNA replication / George Iliakis [and others] -- CHK1 kinase activity assay / Hong Yan Wang and Ya Wang -- Histone H2AX phosphorylation : a marker for DNA damage / Arishya Sharma, Kamini Singh, and Alexandru Almasan.
  • ScienceDirect
    edited by Judith L. Campbell.
    Also available: Print – 1995
  • edited by Melvin L. DePamphilis.
  • 2010
    Jennifer Coyne Albrecht.
    Capillary electrophoresis in a viscous sieving polymer was used to sequence the first human genome by separating DNA molecules on basis of size. Since the completion of the Human Genome Project in 2003, several "next-generation" technologies have offered greatly decreased cost per base and increased throughput of DNA sequencing. While the ultra-high-throughput nature of these technologies is highly advantageous to genome-wide studies, it is not amenable to all situations; electrophoresis-based sequencing remains relevant when a small number of exons need to be sequenced rapidly and accurately. Miniaturized electrophoretic separations on microfluidic devices require less sample volume, a shorter analysis time, and, in principle, can be performed on an inexpensive, disposable platform. The high pressures necessary to load polymer solutions into chips are challenging and difficult to automate. This work presents a method to separate DNA by size with no polymer matrix to enable rapid, accurate DNA sequencing and size-based genotyping on microchips, with an approach that can be automated and/or multiplexed. Free-Solution Conjugate Electrophoresis (FSCE) achieves size-based separations of DNA by virtue of the attachment of a mobility-modifying "drag-tag" to the end of DNA molecules. Drag-tags must be completely monodisperse so that only one bioconjugate peak appears in the electropherogram for each length of DNA. Previous work in the Barron lab focused on the development of highly repetitive polypeptide "protein polymer" drag-tags, since chemically synthesized polymers which were sufficiently large, while also being monodisperse, are not available. However, the Barron lab struggled for seven years to produce recombinant proteins with sufficient length and monodispersity to enable DNA sequencing. This dissertation presents significant improvements to the development and use of protein polymer drag-tags for size-based separations of DNA. The cause of the polydispersity previously plaguing the production and purification of protein polymer drag-tags was discovered and eliminated. A longer, monodisperse protein polymer of the previously designed repetitive "family" enabled an almost 50% increase in read length by capillary electrophoresis, which is the longest FSCE sequencing read ever reported, and is essentially "on par" with the read lengths of current next-generation technologies. The longest drag-tag produced is predicted to be able to sequence at least 400 bases of DNA. A second "family" of repetitive protein polymers was also developed, which allows the addition of positively charged amino acid residues for increased friction without extra length to be tested. For all protein drag-tags, interactions between the slightly positively charged drag-tags and microchannel walls were found to cause increased peak width when more than 3 cationic amino acids were present, despite the use of robust and hydrophilic dynamic wall coatings. Significant work was done to transition FSCE separations of DNA oligomers conjugated to drag-tags onto glass microfluidic devices. An optimal injection method for separations in buffer was discovered, and all the monodisperse drag-tags were able to be injected when conjugated to ssDNA oligomers, including the largest protein (516 amino acids long). Separation efficiency by microchip electrophoresis was tested. Contrary to matrix-based separations, free-solution electrophoresis with drag-tags shows no loss of resolution when electric field strength is increased, up to the maximum of the power supply (E = 700 V/cm). This indicates that the speed of free-solution sequencing separations will be able to be minimized while still achieving single-base resolution, all without the use of a polymeric sieving network. Specific recommendations are made for further research advances necessary to implement FSCE sequencing separations on microchips. In addition to separating DNA sequencing fragments, FSCE was applied to size-based separation of DNA molecules for genotyping using the ligase detection reaction (LDR). Initial proof-of-concept experiments and further multiplexing demonstrated the advantages of FSCE genotyping on plastic and glass microchips. Using four drag-tags, FSCE-LDR was used to identify, simultaneously, all 19 mutant loci in the K-ras gene of diagnostic importance to colorectal cancer in less than 75 seconds on a glass microchip.
  • Springer Protocols
    edited by Colin A. Graham and Allison J.M. Hill.
    Also available: Print – 2001
  • pt. A-B, 1992. ScienceDirect
    pt. B ScienceDirect
    edited by David M.J. Lilley, James E. Dahlberg.
    pt. A. Synthesis and physical analysis of DNA -- pt B. Chemical and electrophoretic analysis of DNA.
    Also available: Print – pt. A-B, 1992.
  • 2012 Springer
    Yves Pommier, editor.
    Introduction and historical perspective / Patrick Forterre -- Human DNA topoisomerase I : structure, enzymology and biology / James J. Champoux -- Mitochondrial topoisomerases / Ilaria Dalla Rosa, Yves Pommier, and Hongliang Zhang -- Structure and mechanism of eukaryotic type IIA topoisomerases / James M. Berger and Neil Osheroff -- Essential functions of topoisomerase III-alpha in the nucleus and mitochondria / Stefanie Hartman Chen, Jianhong Wu, and Tao-shih Hsieh -- DNA topoisomerase I and illegitimate recombination / Céline Auzanneau and Philippe Pourquier -- Topoisomerase-induced DNA damage / Yves Pommier and Neil Osheroff -- Topoisomerases and carcinogenesis : topoisomerases III-alpha and BLM / Mounira Amor-Guéret and Jean-François Riou -- Topoisomerases inhibitors : a paradigm for interfacial inhibition / Christophe Marchand and Yves Pommier -- Topoisomerases I inhibitors : chemical biology / Beverly A. Teicher -- Topoisomerases II inhibitors : chemical biology / Anna Rogojina ... [et al.] -- Topoisomerases I inhibitors : current use and prospects / Yan Makeyev ... [et al.] -- Topoisomerases II inhibitors : current use and prospects / Olivier Mir ... [et al.] -- Transcriptional stress by camptothecin : mechanisms and implications for the drug antitumor activity / Giovanni Capranico ... [et al.] -- Mechanisms regulating cellular responses to DNA topoisomerases I-targeted agents / Piero Benedetti and Mary-Ann Bjornsti -- Tyrosyl-DNA-phosphodiesterase / Thomas S. Dexheimer ... [et al.] -- Ubiquitin and ubiquitin-like proteins in repair of topoisomerases-mediated DNA damage / Shyamal D. Desai -- Repair of topoisomerases II-mediated DNA damage : fixing DNA damage arising from a protein covalently trapped on DNA / John L. Nitiss ... [et al.] -- Topoisomerases and apoptosis / Olivier Sordet and Stéphanie Solier.
  • 2009 Springer
    Blossom Damania, James M. Pipas, editors.
    Polyomavirus life cycle / Ellen Fanning, Xiaorong Zhao, and Xiaohua Jiang -- Transformation by polyomaviruses / Dweepanita Das and Michael J. Imperiale -- Polyomaviruses and disease / Jaime M. Kean and Robert L. Garcea -- The life cycle of human papillomaviruses / Cary A. Moody and Laimonis A. Laimins -- Papillomavirus transformation / Kimberly Johung and Daniel DiMaio -- Papillomaviruses : biology, diversity, and pathogenesis / Hans-Ulrich Bernard -- Adenovirus transformation / Patrick Hearing -- Overview of the large DNA tumor viruses / Subhash C. Verma ... [et al.] -- Epidemiology of EBV infection / Rosemary Rochford -- EBV diseases / Joseph S. Pagano -- The Epstein-Barr virus genome / Jeffery T. Sample ... [et al.] -- Epstein-Barr virus transforming proteins : biologic properties and contribution to oncogenesis / Nancy Raab-Traub -- The Epstein-Barr virus lytic life cycle / Sankar Swaminathan and Shannon Kenney -- Epstein-Barr virus latent infection nuclear proteins : genome maintenance and regulation of lymphocyte cell growth and survival / Eric Johannsen ... [et al.] -- Epstein-Barr virus entry / Richard Longnecker, Lindsey Hutt-Fletcher, and Theodore Jardetzky -- EBV immunotherapy / Leslie E. Huye and Cliona M. Rooney -- KSHV epidemiology and subtype evolution / Gary S. Hayward and Denise Whitby -- Introduction to diseases associated with Kaposi's sarcoma-associated herpesvirus / Patrick S. Moore and Yuan Chang -- Organization and expression of the Kaposi's sarcoma-associated herpesvirus genome / Yan Yuan and Rolf Renne -- KSHV latent genes and their regulation / Dirk P. Dittmer -- Regulation of expression, mode of action and downstream targets of ORF50 protein in KSHV lytic cycle activation / Pey-Jium Chang, Jianjiang Ye, and George Miller -- HHV-8/KSHV proteins involved in signaling and transformation / Silke Hartmann, Thomas F. Schulz, and John Nicholas -- KSHV entry and infection of target cells / Bala Chandran and Neelam Sharma-Walia -- KSHV immune evasion / Chengyu Liang ... [et al.] -- Non-coding regulatory RNAs of the DNA tumor viruses / Christopher S. Sullivan and Bryan R. Cullen -- AIDS and associated malignancies / William J. Harrington, Charles Wood, and C. Wood -- Primate models for gammaherpesvirus-associated malignancies / Ilhem Messaoudi, Blossom Damania, and Scott W. Wong -- Murine gammaherpesvirus 68 infection of mice : a small animal model for characterizing basic aspects of gammaherpesvirus pathogenesis / James Craig Forrest, Laurie T. Krug, and Samuel H. Speck.
  • 2006 Springer Protocols
    edited by W. Mark Saltzman, Hong Shen, Janet L. Brandsma.
    DNA vaccine design / Janet L. Brandsma -- Design of plasmid DNA constructs for vaccines / Donna L. Montgomery and Kristala Jones Prather -- Vaccination with messenger RNA / Stave Pascolo -- A stress protein-facilitated antigen expression system for plasmid DNA vaccines / Petra Riedl ... [et al.] -- In vitro assay of immunostimulatory activities of plasmid vectors / Weiwn Jiang, Charles F. Reich, and David S. Pisetsky -- Delivery of DNA vaccines using electroporation / Shawn Babiuk, Sylvia van Drunen Littel-van den Hurk, and Lorne A. Babiuk -- Needle-free injection of DNA vaccines: a brief overview and methodology / Kanakatte Raviprakash and Kevin R. Porter -- Needle-free delivery of veterinary DNA vaccines / Sylvia van Drunen Littel-van den Hurk, Shawn Babiuk, and Lorne A. Babiuk -- Surface-modified biodegradable microspheres for DNA vaccine delivery / Mark E. Keegan and W. Mark Saltzman -- A dendrimer-like DNA-based vector for DNA delivery: a viral and nonviral hybrid approach / Dan Luo ... [et al.] -- Identification of compartments involved in mammalian subcellular trafficking pathways by indirect immunofluorescence / Anne Doody and David Putnam -- Adjuvant properties of CpG oligonucleotides in primates / Daniela Verthelyi -- Complexes of DNA vaccines with cationic, antigenic peptides are potent, polyvalent CD8+ T-cell stimulating immunogens / Petra Riedl, Jörg Reimann, and Reinhold Schirmbeck -- Prime-boost strategies in DNA vaccines / C. Jane Dale ... [et al.] -- Modifying professional antigen-presenting cells to enhance DNA vaccine potency / Chien-Fu Hung, Mu Yang, and T.C. Wu -- Replicase-based DNA vaccines for allergy treatment / Sandra Scheiblhofer ... [et al.] -- Immunological responses of neonates and infants to DNA vaccines / Martha Sedegah and Stepen L. Hoffman -- DNA vaccines for allergy treatment / Richard Weiss, Sandra Sheiblhofer, and Josef Thalhamer -- Protection from autoimmunity by DNA vaccination against T-cell receptor / Thorsten Buch and Ari Waisman -- The use of bone marrow-chimeric mice in elucidating immune mechanisms / Akiko Iwasaki -- A simple method for the production of plasmid DNA in bioreactors / Kristin Listner, Laura Kizer Bentley, and Michel Chartrain -- Practical methods for supercoiled pDNA production / John Ballantyne -- Production of plasmid DNA in industrial quantities according to cGMP guidelines / Joachim Schorr ... [et al.] -- Large-scale, nonchromatographic purification of plasmid DNA / Jason C. Murphy, Michael A. Winters, and Sangeetha L. Sagar -- Assuring the quality, safety, and efficacy of DNA vaccines / James S. Robertson and Elwyn Griffiths.
  • 2014 Springer Protocols
    edited by Monica Rinaldi, Daniela Fioretti, Sandra Iurescia.
    Blueprint for DNA vaccine design / Sandra Iurescia, Daniela Fioretti, and Monica Rinaldi -- Enhancement of plasmid-mediated transgene expression / Daniela Fioretti, Sandra Iurescia, and Monica Rinaldi -- Strategies for improving DNA vaccine performance/ Sandra Iurescia, Daniela Fioretti, and Monica Rinaldi -- Enhancement of DNA vaccine efficacy by intracellular targeting strategies / Elisabete Borges Freitas ... [et al.] -- Progresses in DNA-based heterologous prime-boost immunization strategies / Ronald J. Jackson, David B. Boyle, and Charani Ranasinghe -- Development of antibiotic-free selection system for safer DNA vaccination / Jeremy M. Luke, Aaron E. Carnes, and James A. Williams -- Electroporation-based DNA delivery technology : methods for gene electrotransfer to skin / Anita Gothelf and Julie Gehl -- DNA vaccination in skin enhanced by electroporation / Kate E. Broderick, Amir S. Khan, and Niranjan Y. Sardesai -- Intradermal vaccination by DNA tattooing / Joost H. van den Berg ... [et al.] -- Microneedle applications for DNA vaccine delivery to the skin / Hae-yong Seok ... [et al.] -- Multivalent DNA-based vectors for DNA vaccine delivery / Young Hoon Roh ... [et al.] -- Superparamagnetic nanoparticle delivery of DNA vaccine / Fatin Nawwab Al-Deen ... [et al.] -- Plasmid fermentation process for DNA immunization applications / Aaron E. Carnes and James A. Williams -- Pharmaceutical grade large-scale plasmid DNA manufacturing process / Marco Schmeer and Martin Schleef -- Protective and therapeutic DNA vaccination against allergic diseases / Almedina Isakovic ... [et al.] -- Immunotherapy for Alzheimer's disease : DNA- and protein-based epitope vaccines / Hayk Davtyan, Irina Petrushina, and Anahit Ghochikyan -- Tetravalent DNA vaccine product as a vaccine candidate against Dengue / Kevin R. Porter, Nimfa Teneza-Mora, and Kanakatte Raviprakash -- DNA vaccination as a treatment for chronic kidney disease / Yuan Min Wang and Stephen I. Alexander.
  • 2012
    Bettina Van Lengerich.
    Vesicle fusion is a central process in transport and communication in biology. In neuronal transmission, synaptic vesicles carrying neurotransmitters dock and fuse to the plasma membrane of the neuron, a process mediated by a combination of several membrane anchored and soluble proteins. Fusion results in the merger of the two apposing lipid bilayers, leading to the exchange of both the lipidic and aqueous components. The fusion reaction is thought to proceed through several stages: first, the membranes are brought into close proximity (docking), second, the outer leaflets mix, but the inner leaflets and contents remain separate (hemi-fusion), and finally, the inner leaflet and contents exchange (full fusion). Due to the complex nature of the fusion reaction and the multitude of proteins involved, the mechanism of the fusion reaction is not well understood. Simplified model systems for vesicle fusion can bring insight into the mechanism by studying the fusion reaction in a more defined and controllable system. This thesis describes a DNA-based model for the protein fusion machinery. Previously, DNA-lipids were used to tether lipid vesicles to glass-supported lipid bilayers. These vesicles could be observed by fluorescence microscopy, and are laterally mobile along the plane parallel to the supported bilayer. DNA-mediated docking between vesicles was characterized, but fusion was not observed due to the fact that the DNA partners were both coupled at the 5' end, so antiparallel hybridization holds the membranes apart. In this work, a new synthesis of DNA-lipid conjugates is described which allows coupling at both the 3' and 5' end of the DNA. Incorporation of complementary DNA-lipids coupled at opposite ends mediates fusion between lipid vesicles. Vesicle fusion was measured in bulk fluorescence assays (Chapter 2 and 3), by both lipid mixing and content mixing assays. The rate of vesicle fusion showed a strong dependence on the number of DNA per vesicle, as well as the sequence of the DNA. Consistent with previous results measured for the docking reaction, fusion was faster for a repeating DNA sequence than for a non-repeating sequence that required full overlap of the strands for hybridization. The role of membrane proximity on the rate of vesicle fusion was investigated in Chapter 3 by insertion of a short spacer sequence at the membrane-proximal end of fusion sequences. The length of the spacer sequence was varied between two and 24 bases, corresponding to length scales of approximately 1-12 nm. Fusion, as measured in bulk assays by lipid and content mixing, decreases systematically as the membranes are held progressively further apart, demonstrating a clear dependence of the rate of the fusion reaction on membrane proximity. While the bulk vesicle fusion assays showed that DNA-lipids can mediate vesicle fusion, these ensemble measurements convolve the multiple steps (docking, hemifusion, and full fusion) of the fusion reaction, complicating any kinetic analysis. In order to image individual vesicle fusion events between tethered vesicles, a new tethering strategy was developed (Chapter 4). This strategy exploits the dependence of DNA hybridization on salt by covalently attaching lipid vesicles to a glass-supported lipid bilayer, then triggering DNA-mediated docking and fusion by spiking the salt concentration. The kinetics of individual vesicle fusion events were subsequently measured using a FRET-based lipid mixing assay for many vesicles (Chapter 6). An analysis of the distribution of waiting times from docking to fusion indicated that this transition occurs in a single step. A second model membrane architecture was used to study individual fusion events between vesicles and a planar bilayer (Chapters 5 and 6). This architecture uses a DNA-tethered planar free-standing bilayer as the target membrane. The kinetics of individual vesicle fusion events to this membrane patch were also consistent with a single step process, as for vesicle to vesicle fusion. In this system, it was also possible to observe content transfer of vesicles containing a self-quenched aqueous dye (Chapter 5). By analyzing the diffusion profile of the dye, it was shown that the dye indeed is transferred into the region below the planar membrane patch, and is not released into the solution above the patch due to vesicle rupture or leakage.
  • 2015 Springer Protocols
    edited by Benoit P. Leblanc and Sebastien Rodrigue.
    Electrophoretic mobility shift assay using radiolabeled DNA probes -- In vitro DNase i footprinting -- Determining the architecture of a protein-DNA complex by combining FeBABE cleavage analyses, 3-D printed structures, and the ICM molsoft program -- In cellulo DNA analysis: LMPCR footprinting -- Southwestern blotting assay -- Single-molecule approaches for the characterization of riboswitch folding mechanisms -- Probing of nascent riboswitch transcripts -- Functional studies of DNA-protein interactions using fret techniques -- Precise identification of genome-wide transcription start sites in bacteria by 5'-rapid amplification of cDNA ends (5'-RACE) -- Analysis of DNA supercoiling induced by DNA-protein interactions -- Precise identification of DNA-binding proteins genomic location by exonuclease coupled chromatin immunoprecipitation (ChIP-exo) -- The cruciform DNA mobility shift assay: A tool to study proteins that recognize bent DNA -- Individual and sequential chromatin immunoprecipitation protocols -- Chromatin endogenous cleavage (ChEC) as a method to quantify protein interaction with genomic DNA in saccharomyces cerevisiae -- Selection and validation of spacer sequences for CRISPR-Cas9 genome editing and transcription regulation in bacteria -- Detection of short-range DNA interactions in mammalian cells using high-resolution circular chromosome conformation capture coupled to deep sequencing -- Global mapping of open chromatin regulatory elements by formaldehyde-assisted isolation of regulatory elements followed by sequencing (FAIRE-seq) -- Aggregate and heatmap representations of genome-wide localization data using VAP, a versatile aggregate profiler -- Circular dichroism for the analysis of protein-DNA interactions -- Quantitative investigation of protein-nucleic acid interactions by biosensor surface plasmon resonance -- Identification of nucleic acid high affinity binding sequences of proteins by SELEX.
  • 2009 Springer Protocols
    edited by Tom Moss and Benoît Leblanc.
    Filter-binding assays / Peter G. Stockley -- Electrophoretic mobility shift assays for the analysis of DNA-protein interactions / Manon Gaudreault ... [et al.] -- DNase I footprinting / Benoît Leblanc and Tom Moss -- Exonuclease III footprinting on immobilized DNA templates / Patrizia Spitalny and Michael Thomm -- Hydroxyl radical footprinting of protein-DNA complexes / Indu Jagannathan and Jeffrey J. Hayes -- The use of diethyl pyrocarbonate and potassium permanganate as probes for strand separation and structural distortions in DNA / Brenda F. Kahl and Marvin R. Paule -- Uranyl photofootprinting / Peter E. Nielsen -- Identification of protein/DNA contacts with dimethyl sulfate : methylation protection and methylation interference / Peter E. Shaw and A. Francis Stewart -- Ethylation interference footprinting of DNA-protein complexes / Iain W. Manfield and Peter G. Stockley -- Site-directed cleavage of DNA by protein-Fe(II) EDTA conjugates within model chromatin complexes / David R. Chafin and Jeffrey J. Hayes -- Identification of nucleic acid high-affinity binding sequences of proteins by SELEX / Philippe Bouvet -- Identification of sequence-specific DNA-binding proteins by southwestern blotting / Simon Labbé, Jean-François Harrisson, and Carl Séguin -- Footprinting DNA-protein interactions in native polyacrylamide gels by chemical nucleolytic activity of 1,10-phenanthroline-copper / Athanasios G. Papavassiliou -- Determination of a transcription factor-binding site by nuclease protection footprinting onto southwestern blots / Athanasios G. Papavassiliou -- Use of a reporter gene assay in yeast for genetic analysis of DNA-protein interactions / David R. Setzer ... [et al.] -- Chromatin immunoprecipitation in mammalian cells / Amy Svotelis, Nicolas Gévry, and Luc Gaudreau -- Sequential chromatin immunoprecipitation protocol : ChIP-reChIP / Mayra Furlan-Magaril, Héctor Rincón-Arano, and Félix Recillas-Targa -- Profiling genome-wide histone modifications and variants by ChIP-chip on tiling microarrays in S. cerevisiae / Alain R. Bataille and François Robert -- Nucleosome mapping / Nicolas Gévry ... [et al.] -- In cellulo DNA analysis (LMPCR footprinting) / Régen Drouin ... [et al.] -- Atomic force microscopy imaging and probing of DNA, proteins, and protein DNA complexes : silatrane surface chemistry / Yuri L. Lyubchenko, Luda S. Shlyakhtenko, and Alexander A. Gall -- Two-dimensional crystallisation of soluble protein complexes / Patrick Schultz, Corinne Crucifix, and Luc Lebeau -- Assays for transcription factor activity / Douglas Browning ... [et al.] -- Ultraviolet crosslinking of DNA protein complexes via 8-azidoadenine / Rainer Meffert ... [et al.] -- Static and kinetic site-specific protein-DNA photocrosslinking : analysis of bacterial transcription initiation complexes / Nikolai Naryshkin ... [et al.] -- Use of site-specific protein-DNA photocrosslinking of purified complexes to analyze the topology of the RNA polymerase II transcription initiation complex / Diane Forget, Céline Domecq, and Benoit Coulombe -- Site-directed DNA crosslinking of large multisubunit protein-DNA complexes / Jim Persinger and Blaine Bartholomew -- Functional studies of DNA-protein interactions using FRET techniques / Simon Blouin ... [et al.] -- Single-molecule FRET analysis of protein-DNA complexes / Mike Heilemann ... [et al.] -- Analysis of DNA supercoiling induced by DNA-protein interactions / David J. Clark and Benoît Leblanc -- The cruciform DNA mobility shift assay : a tool to study proteins that recognize bent DNA / Victor Y. Stefanovsky and Tom Moss -- Plasmid vectors for the analysis of protein-induced DNA bending / Christian Zwieb and Sankar Adhya -- Analysis of distant communication on defined chromatin templates in vitro / Yury S. Polikanov and Vasily M. Studitsky -- A competition assay for DNA binding using the fluorescent probe ANS / Ian A. Taylor and G. Geoff Kneale -- Fluorescence spectroscopy and anisotropy in the analysis of DNA-protein interactions / Rosy Favicchio ... [et al.] -- Circular dichroism for the analysis of protein-DNA interactions / P.D. Cary and G. Geoff Kneale -- Defining the thermodynamics of protein/DNA complexes and their components using micro-calorimetry / Colyn Crane-Robinson, Anatoly I. Dragan, and Christopher M. Read -- Surface plasmon resonance assays of DNA-protein interactions / Peter G. Stockley and Björn Persson.
  • 2002 ScienceDirect
    edited by Thomas Sutula, Asla Pitkänen.
    Also available: Print – 2002
  • 2014
    Sandeep Jauhar.
    "A memoir-expose of the health-care system by a cardiologist and much-praised author"--Provided by publisher. In his memoir Intern, Sandeep Jauhar chronicled the formative years of his residency at a prestigious New York City hospital. Doctored, his harrowing follow-up, observes the crisis of American medicine through the eyes of an attending cardiologist. Hoping for the stability he needs to start a family, Jauhar accepts a position at a massive teaching hospital. With a decade's worth of elite medical training behind him, he is eager to settle down and reap the rewards of countless sleepless nights. Instead, he is confronted with sobering truths. Doctors' morale is getting lower. Cronyism determines referrals, corporate ties distort medical decisions, and unnecessary tests are routinely performed to generate income. Meanwhile, a single patient might see fifteen specialists and still fail to receive a full picture of his actual condition. Jauhar has written an introspective memoir that is also an impassioned plea for reform.--From publisher description.
  • 2011
    Tanya Sheehan.
    "Examines the relationship between photography and medicine in American culture. Focuses on the American Civil War and postbellum Philadelphia to explore how medical models and metaphors helped establish the professional legitimacy of commercial photography while promoting belief in the rehabilitative powers of studio portraiture"--Provided by publisher.
  • 2012
    by Gretchen Long.
    When the slaves got sick : antebellum medical practice -- Sickness rages fearfully among them : a wartime medical crisis and its implications -- We have come out like men : African American military medical care -- We have come to a conclusion to bind ourselves together : African American associations and medical care -- No license; nor no deplomer : regulating private medical practice and public space -- By nature specially fitted for the care of the sufferer : black doctors, nurses, and patients after the war.
  • 2012
    Sylvia A. Pamboukian.
    False professions : defining orthodoxy and quackery -- Orthodoxy or quackery? Anatomy in 'Frankenstein' -- Doctoring in 'Little Dorrit' and 'Bleak house' -- Legerdemain and the physician in Charlotte Brontë's 'Villette' -- Poisons and the poisonous in Wilkie Collins's 'Armadale' -- The Quackery of Arthur Conan Doyle -- The In-laws: orthodoxy and quackery in 'Vernon Galbray'.
  • 2006
    John Middleton, Erica Middleton ; forewords by Sir Liam Donaldson and Peter Wheeler.
    Status: Not Checked OutLane Catalog Record
  • 2009
    Alessia Minicozzi.
    Status: Not Checked OutLane Catalog Record
    "When physicians complete their training, they are given a title of "attending" and given full authority to care for patients. Many researchers assume their training process is complete. However, through a sociological ethnographic study of first-year attending at a prestigious pediatric hospital, many unresolved issues emerge: developing a style of doctoring, acquiring an authoritative role, dealing with professional uncertainty, malpractice, balancing work and family life. Understanding the first-year attending's socialization process can help medical educators expand their body of knowledge and improve patient care."
  • 2014
    edited by David K.C. Cooper.
    Status: Not Checked OutLane Catalog Record
    The medical profession is rich in those who have made names for themselves outside of medicine. The fields of literature, exploration, business, sport, entertainment, and beyond abound with doctors whose interests lie outside medicine. This book, largely written by members of the medical profession, examines the efforts of doctors in non-medical fields. The doctors discussed here are those who are, or were, well-known to the public for their contributions to their non-medical fields of choice. In many cases, the public may have been unaware that a subject was medically qualified. This book provides wide-ranging and comprehensive biographical sketches of forty-two doctors who are best known to the public for their contributions to fields outside of medicine.--Back cover.
  • v. 1-8, 2001
    Status: Not Checked OutLane Catalog Record
    v. 1. Chemical substances A-D -- v. 2. Chemical substances E-O -- v. 3. Chemical substances P-Z -- v. 4. Biological exposure indices -- v. 5. Physical agents.
  • edited by Elaine A. Ostrander, Urs Giger, Kerstin Lindblad-Toh.
  • 2011 ProQuest Safari
    John K. Kruschke.
    This book's organization : read me first! -- Introduction : models we believe in -- What is this stuff called probability? -- Bayes' rule -- Inferring a binomial proportion via exact mathematical analysis -- Inferring a binomial proportion via grid approximation -- Inferring a binomial proportion via the Metropolis algorithm -- Inferring two binomial proportions via Gibbs sampling -- Bernoulli likelihood with hierarchical prior -- Hierarchical modeling and model comparison -- Null hypothesis significance testing -- Bayesian approaches to testing a point ("null") hypothesis -- Goals, power, and sample size -- Overview of the generalized linear model -- Metric predicted variable on a single group -- Metric predicted variable with one metric predictor -- Metric predicted variable with multiple metric predictors -- Metric predicted variable with one nominal predictor -- Metric predicted variable with multiple nominal predictors -- Dichotomous predicted variable -- Ordinal predicted variable -- Contingency table analysis -- Tools in the trunk.
  • 2008 Springer
    edited by Pranee Liamputtong.
  • 2009
    Philip C. Hébert.
    Status: Not Checked OutLane Catalog Record
    Ethics matters: principles and ethically sound medicine -- Almost revolution: autonomy and patient-based care -- No man an island: confidentiality and trust -- Power to heal: truth, lies, and deception in clinical practice -- Power to choose: due care and informed consent -- Waning and waxing self: capacity and incapacity in medical care -- Helping and not harming: beneficience and non-maleficence -- Conduct becoming: medical professionalism and managing error -- Beyond the patient: doing justice in medical care -- Labour pains: ethics and new life -- Dark wood: end-of-life decisions.
  • 2006
    Chisholm, Dan; Saxena, Shekhar; Van Ommeren, Mark.
    Status: Not Checked OutLane Catalog Record
  • 2006
    Felix Müller-Planitz.
    Status: Not Checked OutLane Catalog Record
  • 2008 CRCnetBASE
    Richard L. Davis.
    Introduction -- Domestic violence and violent behavior in general -- Battered statistics harm all victims -- Dating abuse -- The California conundrum : keeping the promise -- Rape and sexual assault -- Mandatory domestic violence arrest policies -- The Colorado star chamber -- Ain't I a victim -- In memoriam -- Rethinking victimization -- Afterword.
  • 2005 ScienceDirect
    editors, S.B. Dunnett ... [et al.].
    Also available: Print – 2005
  • 2005 Springer
    edited by Werner J. Schmidt and Maarten E.A. Reith.
    I. Dopamine -- Dopamine Receptors / Kim A. Neve -- Dopamine Receptor Alternative Splicing / Neil M. Richtand, Laurel M. Pritchard and Lique M. Coolen -- II. Glutamate -- Glutamatergic Pathways : Their Relevance for Psychiatric Diseases / Yoland Smith -- Glutamate Receptors : Ionotropic / Daniel T. Monaghan, Julia C. A. More, Bihua Feng and David E. Jane -- Metabotropic Glutamate Receptors / Krystyna Ossowska -- III. Schizophrenia -- Dopamine and Schizophrenia / Bart A. Ellenbroek -- Glutamate and Schizophrenia and the N-Methyl-d-Aspartate Receptor Hypofunction Hypothesis / Stefan Bleich and Johannes Kornhuber -- Role of Glycine in Schizophrenia / Beate D. Kretschmer -- IV. Depression -- Dopamine and Depression / Phil Skolnick -- Glutamate and Depression / Joaquín Del Río and Diana Frechilla -- V. Stress and Aggression -- Dopamine, Glutamate, and Aggression / Klaus A. Miczek and Eric W. Fish -- VI. Anxiety -- Glutamatergic Systems and Anxiety / David N. Stephens -- VII. Attention Deficit Hyperactivity Disorder -- Dopamine and Glutamate in Attention Deficit Hyperactivity Disorder / James M. Swanson, Nora D. Volkow, Jeffrey Newcorn, B. J. Casey and Robert Moyzis, et al. -- VIII. Addiction -- Dopamine-Glutamate Interactions in Reward-Related Incentive Learning / Richard J. Beninger and Todor V. Gerdjikov -- Sensitization and Relapse : Dopamine-Glutamate Interactions / David A. Baker and Peter W. Kalivas -- Glutamatergic Neurotransmission in Sensitization / Thomas M. Tzschentke -- Glutamatergic Mechanisms of Drug Relapse : Withdrawal and Conditioning Factors / Anton Y. Bespalov and Robert L. Balster -- IX. Neurodegeneration -- Dopamine and Neurodegeneration / Gabriele Gille and Peter Riederer -- Glutamate and Neurodegeneration / Antonello Novelli, Marcos Pérez-Basterrechea and Maria Teresa Fernández-Sánchez -- X. Parkinson's Disease -- Presymptomatic and Symptomatic Stages of Intracerebral Inclusion Body Pathology in Idiopathic Parkinson's Disease / Heiko Braak and Kelly Del Tredici -- Dopamine and Glutamate in Parkinson's Disease : Biochemistry, Clinical Aspects, and Treatment / Heinz Reichmann, Bernd Janetzky and Peter Riederer -- Dopamine and Glutamate in Motor and Cognitive Symptoms of Parkinson's Disease / Werner J. Schmidt -- XI. Huntington's Disease -- Dopamine and Glutamate in Huntington's Disease / Carlos Cepeda, Marjorie A. Ariano and Michael S. Levine -- XII. Dementias -- Dopaminergic and Glutamatergic Systems in Alzheimer's Disease / Paul T. Francis.
  • 2014 ScienceDirect
    edited by Marco Diana, Gaetano Di Chiara and Pier Franco Spano.
    Progress in Brain Research is a well-established international series examining major areas of basic and clinical research within neuroscience, as well as emerging and promising subfields. This volume, concentrates on state-of-the-art of dopamine research: from basic science to clinical applications. It covers topics including thalamostriatal synapses as a substrate for dopamine action; the multilingual nature of dopamine neurons; ethanol-mechanisms along the mesolimbic dopamine system, and much more. Progress in Brain Research is the most acclaimed and accomplished series in neuroscience, firmly established as an extensive documentation of the advances in contemporary brain research. The volumes, some of which are derived from important international symposia, contain authoritative reviews and original articles by invited specialists. The rigorous editing of the volumes assures that they will appeal to all laboratory and clinical brain research workers in the various disciplines: neuroanatomy, neurophysiology, neuropharmacology, neuroendocrinology, neuropathology, basic neurology, biological psychiatry, and the behavioral sciences.The most acclaimed and accomplished series in neuroscienceThis volume looks at dopamine researchin the light of the newest scholarly discoveries and insights.
  • 2013 Springer Protocols
    edited by Nadine Kabbani.
  • 2015 Springer Protocols
    edited by Mario Tiberi.
    Genetic and epigenetic methods for analysis of the dopamine D2 receptor gene / Laura M. Fiori , Mireille Daigle , and Paul R. Albert -- Characterization of D1 dopamine receptor posttranscriptional regulation / Eldo V. Kuzhikandathil -- Computational approaches in the structure-function studies of dopamine receptors / Mayako Michino and Lei Shi -- Cell-free protein synthesis and purification of the dopamine D2 receptor / Dipannita Basu ... [et al.] -- Wnt ligand binding to and regulation of dopamine D2 receptors / Sehyoun Yoon , Mi-Hyun Choi , and Ja-Hyun Baik -- Regulation of pre- and postsynaptic protein phosphorylation by dopamine D2 receptors / Alessandra Bonito-Oliva, Giada Spigolon, and Gilberto Fisone -- Study of dopamine D1 receptor regulation by G protein-coupled receptor kinases using whole-cell phosphorylation and cross-linking methods / Keyvan Sedaghat ... [et al.] -- Ubiquitination of dopamine receptor studied by sequential double immunoprecipitation / Kamila Skieterska, Pieter Rondou, and Kathleen Van Craenenbroeck -- Dopamine receptors in the subthalamic nucleus : identification and localization of D5 receptors / Lionel Froux ... [et al.] -- MALDI mass spectrometry imaging of dopamine and PET D1 and D2 receptor ligands in rodent brain tissues / Richard J. A. Goodwin, Mohammadreza Shariatgorji, and Per E. Andren -- Positron emission tomography imaging of dopaminergic receptors in rats / Boguslaw Szczupak and Abraham Martín -- Transactivation of receptor tyrosine kinases by dopamine receptors / Jeff S. Kruk ... [et al.] -- Dopamine receptors in human embryonic stem cell differentiation / Glenn S. Belinsky ... [et al.] -- Calcium and phospholipase Cβ signaling through dopamine receptors / Lani S. Chun, R. Benjamin Free, and David R. Sibley -- Intracellular trafficking assays for dopamine D2-like receptors / Chengchun Min, Mei Zheng, and Kyeong-Man Kim -- Study of crosstalk between dopamine receptors and ion channels / Ping Su, Albert H. C. Wong, and Fang Liu -- Study of dopamine receptor and dopamine transporter networks in mice / Victor Gorgievski, Eleni T. Tzavara, and Bruno Giros -- Optogenetic regulation of dopamine receptor-expressing neurons / T. Chase Francis and Mary Kay Lobo -- Characterization of D3 dopamine receptor agonist-dependent tolerance property / Samantha R. Cote and Eldo V. Kuzhikandathil -- Dopamine D1 and D2 receptors in chronic mild stress : analysis of dynamic receptor changes in an animal model of depression using in situ hybridization and autoradiography / Dariusz Zurawek ... [et al.].
  • 2010 Springer
    Kim A. Neve, editor.
    Also available: Print – 2010
  • 2010 Springer
    Detlef Thieme, Peter Hemmersbach, editors.
    History of doping and doping control -- Biochemical and physiological aspects of endogenous androgens -- Phase-II metabolism of androgens and its relevance for doping control analysis -- Detecting the administration of endogenous anabolic androgenic steroids -- Synthetic anabolic agents: steroids and nonsteroidal selective androgen receptor modulators -- Nandrolone: a multi-faceted doping agent -- Designer steroids -- Growth hormone -- Mass spectrometry-based analysis of IGF-1 and hGH -- Insulin -- [Beta]-adrenergic stimulation -- Erythropoietin and analogs -- Blood transfusion in sports -- Athlete's biological passport and indirect markers of blood doping -- Masking and manipulation -- Hormonal growth promoting agents in food producing animals -- Some aspects of doping and medication control in equine sports -- Androgenic anabolic steroid abuse and the cardiovascular system -- Side effects of anabolic androgenic steroids: pathological findings and structure-activity relationships -- Gene doping -- Science and the rules governing anti-doping violations.
  • 2015 Springer
    Karl-Heinz Deeg, Thomas Rupprecht, Michael Hofbeck ; with contributions by Doris Franke, Michael Riccabona, Heiko Dudwiesus.
    This book covers the full range of current applications of Doppler sonography in infancy and childhood, describing the variety of potential findings with the aid of a wealth of images. After an introductory chapter on the physical and technical basis of Doppler sonography, applications of cerebral Doppler sonography in infancy and of transcranial Doppler sonography in childhood are addressed, with numerous examples of imaging appearances. The major part of the book is devoted to Doppler sonography of the brain, face and neck and of the abdomen, covering normal abdominal vessels, liver, spleen, pancreas, and mesenteric and renal circulation. Imaging of the ovaries and testes is also presented, encompassing the differential diagnosis of acute scrotum and other space-occupying lesions of the testis. The book closes by considering Doppler sonography of soft tissue and vascular malformations, and the influence of congenital heart malformations on flow parameters in peripheral arteries. Doppler Sonography in Infancy and Childhood will be an invaluable reference for pediatricians, neonatologists, pediatric sonographers, and pediatric and general radiologists.
  • 2005 Springer
    editor, Dev Maulik ; associate editor for gynecology, Ivica Zalud.
    Also available: Print – 2005
  • 2016 ClinicalKey
    Bogdan Czerniak.
    General considerations -- Clinical considerations and imaging of bone tumors / Colleen M. Costelloe and John E. Madewell -- Molecular biology of bone tumors -- Benign osteoblastic tumors -- Osteosarcoma -- Benign cartilage lesions -- Malignant cartilage tumors -- Fibroosseous lesions -- Fibrous and fibrohistiocytic lesions -- Giant-cell lesions -- Ewing's sarcoma and related entities -- Hematopoietic tumors / April Ewton -- Vascular lesions -- Neurogenous tumors and neurofibromatosis affecting bone / Gregory N. Fuller -- Cystic lesions -- Miscellaneous mesenchymal tumors -- Adamantinoma of long bone -- Chordoma and related lesions -- Metastic tumors in bone / John D. Reith -- Synovial lesions -- Sclerosing bone lesions -- Tumor-induced osteomalacia and rickets -- Reactive and metabolic conditions simulating neoplasms of bone -- Precancerous conditions.
  • 2016 ClinicalKey
    Jablonski, Stanley.
  • 1988, 2000-<2012>
    Dorland, W. A. Newman.
    Status: Not Checked OutLane Catalog Record
    Also available: Print – 1965-2007
    Also available: Print – <2012>
  • 2010 Springer
    [edited by] Esther Lubzens, Joan Cerdà, Melody Clark.
    Many organisms have evolved the ability to enter into and revive from a dormant state. They can survive for long periods in this state (often even months to years), yet can become responsive again within minutes or hours. This is often, but not necessarily, associated with desiccation. Preserving one 's body and reviving it in future generations is a dream of mankind. To date, however, we have failed to learn how cells, tissues or entire organisms can be made dormant or be effectively revived at ambient temperatures. In this book studies on organisms, ranging from aquatic cyanobacteria that produce akinetes to hibernating mammals, are presented, and reveal common but also divergent physiological and molecular pathways for surviving in a dormant form or for tolerating harsh environments. Attempting to learn the functions associated with dormancy and how they are regulated is one of the great future challenges. Its relevance to the preservation of cells and tissues is one of the key concerns of this book
  • 2011 CRCnetBASE
    Ying Kuen Cheung.
    Part I. Fundamentals -- Chapter 1. Introduction -- Chapter 2. Dose Finding in Clinical Trials -- Chapter 3. The Continual Reassessment Method -- Chapter 4. One-Parameter Dose-Toxicity Models -- Chapter 5. Theoretical Properties -- Chapter 6. Empirical Properties -- Part II. Design Calibration -- Chapter 7. Specifications of a CRM Design -- Chapter 8. Initial Guesses of Toxicity Probabilities -- Chapter 9. Least Informative Normal Prior -- Chapter 10. Initial Design -- Part III. CRM and Beyond -- Chapter 11. The Time-to-Event CRM -- Chapter 12. CRM with Multiparameter Models -- Chapter 13. When the CRM Fails -- Chapter 14. Stochastic Approximation.
  • 2006 Springer
    Naitee Ting, editor.
  • 2006 CRCnetBASE
    edited by Rajesh Krishna.
  • 2008 HighWire
    International Commission on Radiation Units and Measurements.
  • 2008 Springer
    K.-K. Dittel, M. Rapp, eds. ; in collaboration with W. Abendschein ... [et al.].
  • 2006 Springer
    Val Raghavan.
  • 2006 Springer
    K. Sugano, editor in chief ; H. Yamamoto, H. Kita, editors.
  • David Michaels.
    ""Doubt is our product," a cigarette executive once observed, "since it is the best means of competing with the 'body of fact' that exists in the minds of the general public. It is also the means of establishing a controversy."" "In this expose, David Michaels reveals just how prevalent - and how effective - such strategies have become. He argues that to keep the public confused about the hazards posed by global warming, secondhand smoke, asbestos, lead, plastics, and many other toxic materials, industry executives have hired unscrupulous scientists and lobbyists to dispute the scientific evidence that would alert the public to these dangers. Their goal is the manufacture of doubt."--BOOK JACKET.
  • 2009 Springer
    André Khoury-Hélou et Philippe Zerbib.
  • 2013 Springer
    Milind Watve.
    1. A Darwinian Way of Thinking -- 2. Diabetes in a Textbook -- 3. Diabetes in an Undergraduate Class -- 4. The Rise and Fall of Thrift -- 5. Of Hawks and Doves -- 6. Of Soldiers and Diplomats -- 7. The Physiology of Aggression -- 8. Deploying the Immunological Garrison -- 9. Why Population Density Matters -- 10. Time to Give Up Stress -- 11. Fat: Beyond Energy Storage -- 12. Why Blood Sugar Goes Up -- 13. Beating Around the "Wrong" Bush? -- 14. Behavioral Deficiencies and Behavioral Supplementation -- 15. Where Do We Go From Here?
  • 2012 ScienceDirect
    edited by Mara Dierssen, Rafael de la Torre.
    Therapeutic approaches in the improvement of cognitive performance in Down syndrome: past, present, and future / R. de la Torre and M. Dierssen -- Genomic determinants in the phenotypic variability of Down syndrome / A. Letourneau and S.E. Antonarakis -- Intellectual disabilities, neuronal posttranscriptional RNA metabolism, and RNA-binding proteins: three actors for a complex scenario / B. Bardoni ... [et al.] -- Aberrant epigenetic landscape in intellectual disability / J.V. Sanchez-Mut, D. Huertas and M. Esteller -- Pathways to cognitive deficits in Down syndrome / X. Sturgeon ... [et al.] -- Neurological phenotypes for Down syndrome across the life span / I.T. Lott -- Human and mouse model cognitive phenotypes in Down syndrome: implications for assessment / J.O. Edgin ... [et al.] -- Perturbation of dendritic protrusions in intellectual disability / J. Levenga and R. Willemsen -- The in vivo Down syndrome genomic library in mouse / Y. Herault ... [et al.] -- Discoveries in Down syndrome: moving basic science to clinical care -- A.M. Kleschevnikov ... [et al.] -- A Sonic hedgehog (Shh) response deficit in trisomic cells may be a common denominator for multiple features of Down syndrome / D.G. Currier, R.C. Polk and R.H. Reeves -- Gene therapy for Down syndrome / C. Fillat and X. Altafaj.
  • 2011
    Elizabeth Ahrens-Kley.
  • 2011
    prepared by Barbara Lawson, Pamela Miller, and Kristen Dobbin.
  • 2011 Thieme Book
    Hildegard Wittlinger [and others] ; [translator, Ruth Gutberlet ; illustrator, Emil Wolfgang Hanns].
    Anatomy and physiology of the circulation of the blood -- Lymphatic system -- Physiology of the lymphatic system, lymph, and interstitium -- Lymphedema -- Equilibrium and balance as the aim of the massage -- Indications and contraindications for manual lymph drainage -- Effect of manual lymph drainage on the smooth muscles of blood vessels and lymphangions -- Diagnostic examination and edema measurement -- Massage techniques -- Treatments of the individual parts of the body -- Special techniques -- Treatment model for secondary lymphedema -- Complementary treatments.
  • 2009 ATSDR
    prepared by Syracuse Research Corporation ; prepared for U.S. Department of Health and Human Services, Public Health Service, Agency for Toxic Substances and Disease Registry.
    Also available: Print – 2009
  • 2006
    prepared by Syracuse Research Corporation under contract no. 200-2004-09793 ; prepared for U.S. Department of Health and Human Services, Public Health Service, Agency for Toxic Substances and Disease Registry.
    Status: Not Checked OutLane Catalog Record
  • 2007 ATSDR
    U.S. Department of Health and Human Services, Public Health Service, Agency for Toxic Substances and Disease Registry.
    Also available: Print – 2007
  • 2009 ATSDR
    prepared by SRC, Inc. ; prepared for U.S. Department of Health and Human Services, Public Health Service, Agency for Toxic Substances and Disease Registry.
    Also available: Print – 2009
  • 2008 ATSDR
    prepared by Syracuse Research Corporation Under contract no. 200-2004-09793 ; prepared for U.S. Department of Health and Human Services, Public Health Service, Agency for Toxic Substances and Disease Registry.
    Also available: Print – 2008
  • 2009 ATSDR
    prepared by SRC, Inc. ; prepared for U.S. Department of Health and Human Services, Public Health Service, Agency for Toxic Substances and Disease Registry.
    Also available: Print – 2009
  • 2007
    prepared by Syracuse Research Corporation under contract no. 200-2004-09793 ; prepared for U.S. Department of Health and Human Services, Public Health Service, Agency for Toxic Substances and Disease Registry.
    Status: Not Checked OutLane Catalog Record
  • 2008 ATSDR
    prepared by Syracuse Research Corporation under contract no. 200-2004-09793 ; prepared for U.S. Department of Health and Human Services, Public Health Service, Agency for Toxic Substances and Disease Registry.
    Also available: Print – 2008
  • 2006
    prepared by Syracuse Research Corporation under contract no. 200-2004-0979 ; prepared for U.S. Department of Health and Human Services, Public Health Service, Agency for Toxic Substances and Disease Registry.
    Status: Not Checked OutLane Catalog Record
  • 2006
    prepared by Syracuse Research Corporation under contract no. 200-2004-09793 ; prepared for U.S. Department of Health and Human Services, Public Health Service, Agency for Toxic Substances and Disease Registry.
    Status: Not Checked OutLane Catalog Record
  • 2006
    prepared by Syracuse Research Corporation under contract no. 200-2004-09793 ; prepared for U.S. Department of Health and Human Services, Public Health Service, Agency for Toxic Substances and Disease Registry.
    Status: Not Checked OutLane Catalog Record
  • 2007 ATSDR
    U.S. Department of Health and Human Services, Public Health Service, Agency for Toxic Substances and Disease Registry.
    Also available: Print – 2007
  • 2007
    U.S. Department of Health and Human Services, Public Health Service, Agency for Toxic Substances and Disease Registry.
    Status: Not Checked OutLane Catalog Record
  • 2007
    prepared by Syracuse Research Corporation under contract no. 200-2004-09793 ; prepared for U.S. Department of Health and Human Services, Public Health Service, Agency for Toxic Substances and Disease Registry.
    Status: Not Checked OutLane Catalog Record
  • 2006
    prepared by Syracuse Research Corporation under contract no. 200-2004-09793 ; prepared for U.S. Department of Health and Human Services, Public Health Service, Agency for Toxic Substances and Disease Registry.
    Status: Not Checked OutLane Catalog Record
  • 2008 ATSDR
    prepared by Syracuse Research Corporation under contract no. 200-2004-09793 ; prepared for U.S. Department of Health and Human Services, Public Health Service, Agency for Toxic Substances and Disease Registry.
    Also available: Print – 2008
  • 2009 ATSDR
    prepared by SRC, Inc. under contract no. 200-2004-09793 ; prepared for U.S. Department of Health and Human Services, Public Health Service, Agency for Toxic Substances and Disease Registry.
    Also available: Print – 2009
  • 2006
    prepared by Syracuse Research Corporation under contract no. 200-2004-09793 ; prepared for U.S. Department of Health and Human Services, Public Health Service, Agency for Toxic Substances and Disease Registry.
    Status: Not Checked OutLane Catalog Record
  • 2009 ATSDR
    prepared by SRC, Inc. ; prepared for U.S. Department of Health and Human Services, Public Health Service, Agency for Toxic Substances and Disease Registry.
    Also available: Print – 2009
  • 2007 ATSDR
    prepared by Syracuse Research Corporation under contract no. 200-2004-09793 ; prepared for U.S. Department of Health and Human Services, Public Health Service, Agency for Toxic Substances and Disease Registry.
    Also available: Print – 2007
  • 2008 ATSDR
    prepared by Syracuse Research Corporation under contract no. 200-2004-09793 ; prepared for U.S. Department of Health and Human Services, Public Health Service, Agency for Toxic Substances and Disease Registry.
    Also available: Print – 2008
  • 2010 ATSDR
    prepared by SRC, Inc. under contract no. 200-2004-09793 ; prepared for U.S. Department of Health and Human Services, Public Health Service, Agency for Toxic Substances and Disease Registry.
    Also available: Print – 2010
  • 2007 ATSDR
    prepared by Syracuse Research Corporation under contract No. 200-2004-09793 ; prepared for U.S. Department of Health and Human Services, Public Health Service, Agency for Toxic Substances and Disease Registry.
    Also available: Print – 2007
  • 2006
    prepared by Syracuse Research Corporation under conract no. 200-2004-09793 ; prepared for U.S. Department of Health and Human Services, Public Health Service, Agency for Toxic Substances and Disease Registry.
    Status: Not Checked OutLane Catalog Record
  • 2009 ATSDR
    prepared by SRC, Inc. under contract no. 200-2004-09793 ; prepared for U.S. Department of Health and Human Services, Public Health Service, Agency for Toxic Substances and Disease Registry.
    Also available: Print – 2009
  • 2014 Cambridge
    Susan Ward, Consultant Obstetrician and Gynaecologist, Kings Mill Hospital, Sherwood Forest Hospitals Trust, Sutton-in-Ashfield, Nottinghamshire, UK ; with contributions from Lisa Joels, Consultant Obstetrician and Gynaecologist, Royal Devon and Exeter NHS Foundation Trust, Exeter, Devon, UK, Elaine Melrose, Retired Consultant Obstetrician and Gynaecologist, Ayreshire Maternity Unit and Crossroads Hospitals, Kilmarnock, Ayrshire, UK, Srinivas Vindla, Consultant Obstetrician and Gynaecologist, Kings Mill Hospital, Sherwood Forest Hospitals Trust, Sutton-in-Ashfield, Nottinghamshire, UK.
    The DRCOG examination -- Curriculum module 1: basic clinical skills -- Curriculum module 2: basic surgical skills and surgical procedures -- Curriculum module 3: antenatal care -- Curriculum module 4: management of labour and delivery -- Curriculum module 5: postpartum problems (the puerperium) including neonatal problems -- Curriculum module 6: gynaecological problems -- Curriculum module 7: fertility control (contraception and termination of pregnancy).
  • 2010
    editors, James J. McCarthy, James C. Drennan.
    Status: Not Checked OutLane Catalog Record
  • 2013 Wiley
    edited by Cesarettin Alasalvar, Fereidoon Shahidi.
    Dried fruits serve as important healthful snack items around the world. They provide a concentrated form of fresh fruits, prepared by different drying techniques. With their unique combination of taste/aroma, essential nutrients, fibre, and phytochemicals or bioactive compounds, dried fruits are convenient for healthy eating and can bridge the gap between recommended intake of fruits and actual consumption. Dried fruits are nutritionally equivalent to fresh fruits, in smaller serving sizes, in the current dietary recommendations of various countries. Scientific evidence suggests that indivi.
  • 2016 ebrary
    Guenter B. Risse.
  • 2010 Karger
    editors, Berthold Koletzko, Sibylle Koletzko, Frank Rümmele.
    Innovations in infant milk feeding : from the past to the future / Koletzko, B. -- Novel insights into human lactation as a driver of infant formula development / Lønnerdal, B. -- The clinical challenge of preventing and treating malnutrition / Cooper, P.A. -- Progress of enteral feeding practice over time : moving from energy supply to patient-and disease-adapted formulationse / Koletzko, S. -- Molecular mechanisms of pediatric nutrition / Rümmele, F. -- Epidemiological research drives a paradigm shift in complementary feeding : the celiac disease story and lessons learnt / Nordyke, K. ... [et al.] -- Technological progress as a driver of innovation in infant foods / Ferruzzi, M.G.; Neilson, A.P. -- Health economic perspectives of pediatric malnutrition : determinants of innovative progress / Spieldenner, J. -- Economic perspectives on pediatric obesity : impact on health care expenditures and cost-effectiveness of preventive interventions / John, J. -- Sustainable clinical research, health economic aspects, and marketing : drivers of product innovation / Haschke, F.; Klassen-Wigger, P. -- Evaluation of dietetic product innovations : the relative role of preclinical and clinical studies / Makrides, M.; Gibson, R.A. -- Regulatory environment and claims : limits and opportunities / Martin, A. -- The role of consumers / Raats, M.M. -- Bioethics and innovation in pediatric nutrition research / Solomons, N.W. -- The role of pediatricians as innovators in pediatric nutrition / Greer, F.R. -- Promoting innovation in pediatric nutrition / Bier, D.M.
  • Office of Applied Studies; [compiled by] Tara N. Townsend ... [et al.].
  • 2006 ScienceDirect
    Therese A. Markow, Patrick O'Grady.
  • 2008 Springer Protocols
    edited by Christian Dahmann.
    Drosophila melanogaster and the development of biology in the 20th century / Alfonso Martinez Arias -- Getting started : an overview on raising and handling Drosophila / Hugo Stocker and Peter Gallant -- FlyBase : a database for the Drosophila research community / Rachel Drysdale and the FlyBase Consortium -- The use of P-element transposons to generate transgenic flies / André Bachmann and Elisabeth Knust -- The GAL4 system : a verstile system for the expression of genes / David A. Elliott and Andrea H. Brand -- P-element mutagenesis / Thomas Hummel and Christian Klämbt -- EMS screens : from mutagenesis to screening and mapping / Christian Bökel -- RNAi screening in cultured Drosophila cells / Sandra Steinbrink and Michael Boutros -- Methods for homologous recombination in Drosophila / Keith A. Maggert, Wei J. Gong, and Kent G. Golic -- Recombinases and their use in gene activation, gene inactivation, and transgenesis / Johannes Bischof and Konrad Basler -- Cuticle preparation of Drosophila embryos and larvae / Cyrille Alexandre -- Immunolabeling of embryos / H.-Arno J. Müller -- Imaging cellular and molecular dynamics in live embryos using fluorescent proteins / Matthieu Cavey and Thomas Lecuit -- Analysis of neuromuscular junctions : histology and in vivo imaging / Andreas Schmid and Stephan J. Sigrist -- Immunolabeling of imaginal discs / Thomas Klein -- Imaging Drosophila pupal wing morphogenesis / Anne-Kathrin Classen ... [et al.] -- Microscopic analysis of the adult Drosophila retina using semithin plastic section / Konstantin Gaengel and Marek Mlodzik -- Fluorescent in situ hybridization protocols in Drosophila embryos and tissues / Eric Lécuyer, Neela Parthasarathy, and Henry M. Krause -- Linear RNA amplification for the production of microarray hybridization probes / Ansgar Klebes and Thomas B. Kornberg -- An overview of the identification, detection, and functional analysis of Drosophila microRNAs / Nicholas S. Sokol -- Extraction and immunoblotting of proteins from embryos / Andreas Wodarz -- Purification of Drosophila protein complexes for mass spectrometry / Christoph Jüschke and Jürgen A. Knoblich -- Mass production of Drosophila embryos and chromatographic purification of native protein complexes / Natascha Kunert and Alexander Brehm -- Flow cytometric analysis of Drosophila cells / Aida Flor A. de la Cruz and Bruce A. Edgar -- Drosophila cell lines as model systems and as an experimental tool / Buzz Baum and Lucy Cherbas -- Appendix : phenotypic markers in Drosophila / Jennifer Childress and Georg Halder.
  • 2009
    Yufeng Yang.
    Status: Not Checked OutLane Catalog Record
  • 2012
    Heather Briana DeBruhl.
    The Myb gene family plays a role in several types of human cancers. For example, high expression levels of c-Myb in colon cancer and B-Myb in breast cancer correlated with poor prognosis for the patient. B-Myb, the vertebrate homolog of invertebrate Myb, activates transcription of mitotic genes. In Drosophila, mutation of Myb reduced expression of mitotic genes, such as the regulatory kinase genes polo and ial (AurB). Previous studies revealed multiple mitotic defects in Myb mutant cells, including disrupted chromosome condensation and abnormal spindles. I now show that binucleate cells, the hallmark phenotype of cytokinesis failure, accumulate in Myb-null ovarian follicle cell and wing disc epithelia. Myb functions as an activator in the generally repressive Drosophila RBF, E2F2, and Myb (dREAM)/Myb-MuvB complex. Absence of the dREAM subunits Mip130 or E2F2 suppressed the Myb-null cytokinesis defect. While previous Myb-null mitotic phenotypes were difficult to quantitatively assay, the binucleate phenotype was binary, countable, and had a near zero background level in wild-type tissues. This offered a unique opportunity to use the Myb-null binucleate phenotype to study how the dREAM complex represses transcription. In the absence of Myb, repression by the dREAM complex was sensitive to the decreased dose of the subunits E2F2, Mip120, Caf1, and interestingly Lin-52, which was previously genetically implicated as an activator in the complex. Surprisingly, reducing the dose of His2Av also suppressed the Myb-null binucleate phenotype, suggesting a novel role for this variant histone in transcriptional repression by the dREAM complex.
  • 2015 Springer Protocols
    edited by Diana P. Bratu, Gerard P. McNeil.
    Drosophila melanogaster oogenesis : an overview / John M. McLaughlin and Diana P. Bratu -- Basic techniques in Drosophila ovary preparation / Letitia Thompson, Kristen Randolph, and Amanda Norvell -- Mosaic analysis in the Drosophila melanogaster ovary / Thomas Rubin and Jean-René Huynh -- Genetic mosaic analysis of stem cell lineages in the Drosophila ovary / Kaitlin M. Laws and Daniela Drummond-Barbosa -- Culturing Drosophila egg chambers and investigating developmental processes through live imaging / Lathiena Manning and Michelle Starz-Gaiano -- Border cell migration : a model system for live imaging and genetic analysis of collective cell movement / Mohit Prasad [and four others] -- Visualizing microtubule networks during Drosophila oogenesis using fixed and live Imaging / Kevin Legent, Nicolas Tissot, and Antoine Guichet -- Visualization of actin cytoskeletal dynamics in fixed and live Drosophila egg chambers / Christopher M. Groen and Tina L. Tootle -- Single-molecule RNA in situ hybridization (smFISH) and immunofluorescence (IF) in the Drosophila egg chamber / Livia V. Bayer [and three others] -- Fluorescent in situ hybridization of nuclear bodies in Drosophila melanogaster ovaries / Zehra F. Nizami, Ji-Long Liu, and Joseph G. Gall -- Ultrastructural analysis of Drosophila ovaries by electron microscopy / Thomas R. Hurd [and seven others] -- Immuno-electron microscopy and electron microscopic in situ hybridization for visualizing piRNA biogenesis bodies in Drosophila ovaries / Shinsuke Shibata [and six others] -- Visualizing cytoophidia expression in Drosophila follicle cells via immunohistochemistry / Ömür Y. Tastan and Ji-Long Liu -- Detection of cell death and phagocytosis in the Drosophila ovary / Tracy L. Meehan [and three others] -- Analysis of cell cycle switches in Drosophila oogenesis / Dongyu Jia , Yi-Chun Huang , and Wu-Min Deng -- Global run-on sequencing (GRO-seq) library preparation from Drosophila ovaries / Nikolay V. Rozhkov -- Bioinformatics analysis to identify RNA-protein interactions in oogenesis / Ravinder Singh.
  • 2014 Springer
    edited by Joost J.L.M. Bierens.
    Since the first edition of the Handbook on Drowning in 2005, many epidemiological data have confirmed the burden of drowning in several parts of the world. Studies have increased the understanding of effective drowning prevention strategies, rescue techniques, and treatment options. Much has been learned about submersion and immersion hypothermia, SCUBA-diving injuries, the life-saving preparations of water-related disasters and how to deal with forensic investigations. In this updated second edition, experts from around the world provide a complete overview of current research data, consensus statements and expert opinions. The book Drowning provides evidence-based practical information and has a unique informative value for various groups with tasks, duties and responsibilities in this domain. In addition, the book may be an inspiration for future networks and research initiatives.
  • 2008 Springer
    Carsten Ehrhardt, Kwang-jin Kim, editors.
  • 2007 CRCnetBASE
    editor-in-chief, Steven B. Karch.
    Criminalistics: introduction to controlled substances / Joseph P. Bono -- Pathology of drug abuse / edited by Charles V. Wetli -- Pharmacokinetics: drug absorption, distribution, and elimination / Amanda J. Jenkins -- Pharmacodynamics / edited by Stephen J. Heishman -- Alcohol / edited by Alan Wayne Jones -- Neurochemistry of drug abuse / edited by Julie K. Staley and Kelly P. Cosgrove -- Addiction medicine / edited by Kim Wolff -- Medical complications of drug abuse / edited by Neal L. Benowitz -- Sports / edited by Marc D. Bollmann and Martial Saugy -- Workplace testing / edited by Yale H. Caplan and Marilyn A. Huestis -- Point of collection drug testing / edited by Dennis J. Crouch -- Post-mortem toxicology / edited by Henrik Druid -- Toxicogenetics / edited by Steven B. Karch -- Drug law -- Appendices.
  • 2011
    Jae Y. Choe.
    Status: Not Checked OutLane Catalog Record
  • v. 1-4, 1972-74.
    edited by Jasbir M. Singh, Lyle Miller, Harbans Lal.
    Status: Not Checked OutLane Catalog Record
    v. 1. Experimental pharmacology -- v. 2. Clinical and socio-legal aspects -- v. 3. Neurobiology and influences on behaviour -- v. 4. New aspects of analytical and clinical toxicology.
  • 2008 Springer
    edited by Rao S. Rapaka, Wolfgang Sadée.
  • 2013 Springer
    Brian A. Baldo, Nghia H Pham.
    Adverse reactions to drugs and drug allergy: scope of this book --Classification and descriptions of allergic reactions to drugs -- Mechanisms of hypersensitivity -- Diagnosis of allergic reactions to drugs -- β-lacam antibiotics -- Other antimicrobial drugs -- Drugs and other agents used in anesthesia and surgery -- Opiod analgesic drugs -- Nonsteroidal anti-inflammatory drugs -- Contrast media -- Biologics -- Corticosteroids -- Drugs used for chemotherapy -- Proton pump inhibitors -- Postface-concluding remarks.
  • 2006 Springer
    Marc A. Schuckit.
    Depressants -- Alcoholism: an introduction -- Alcoholism: acute treatment -- Stimulants: amphetamines and cocaine -- Opioids and other analgesics -- Cannabinols -- Hallucinogens and related drugs -- Glues, inhalants and aeorsols -- Over-the-counter (OTC) drugs and some prescription drugs -- Xanthines (caffeine) and nicotine -- Multidrug abuse and dependence -- Emergency problems: a quick overview -- Rehabilitation.
  • 2007 Springer
    editor, Ronald P. Evens.
  • ScienceDirect
    edited by Kenneth J. Widder, Ralph Green.
    Also available: Print – 1985
  • ScienceDirect
    edited by Ralph Green, Kenneth J. Widder.
    Also available: Print – 1987
  • 2010 Springer
    Monika Schäfer-Korting, editor.
    This volume gives a topical overview of various modern approaches to drug targeting covering today's options for specific carrier systems allowing successful drug treatment at various sites of the body difficult to address and increasing the benefit-risk-ratio.
  • 2014 Wiley
    edited by Chun Li, Mei Tian.
    Introduction to molecular imaging / Vikas Kundra -- PET/SPECT : instrumentation and imaging techniques / Yuan-Chuan Tai -- Photoacoustic tomography and its application in drug delivery and photothermal therapy / Liang Song Lihong Wang -- Raman microspectral imaging for label-free detection of nanoparticle-mediated cellular and sub-cellular drug delivery / Tatyana Chernenko ... [et al.] -- Anatomical and functional MRIi / Edward F. Jackson -- Quantitative imaging in drug delivery / Kooresh Shoghi -- PET imaging of small-molecular-weight drug pharmacokinetics / Stephen M. Moerlein and Zhude Tu -- Imaging peptides, proteins, and antibody delivery / F. L. Giesel and C. Kratochwil -- In vivo imaging and delivery of siRNA / Zdravka Medarova and Anna Moore -- Imaging cell therapy / Yijie Linag and Jeff W.M. Bulte -- Radiolabeled liposomes as drug delivery nano-theranostics / William T. Phillips ... [et al.] -- Polymeric micelles as imaging agents and drug delivery systems / Jun Zhao and Chun Li -- Perfluorocarbon nanoparticles: translating bench opportunities to the clinic / G.M. Lanza ... [et al.] -- Cancer theranostics with hollow gold nanospheres / Wei Lu and Chun Li -- Imaging pulmonary drug delivery / Stephen Newman -- In-vivo imaging for validation of oral dose performance / Fiona McInnes and Howard Stevens -- Role of large animal models in translational studies of imaging and targeted drug delivery / Rajesh K. Uthamanthil and Mei Tian -- Imaging transcatheter delivery to liver tumors / Adil AL-Nahhas, Meeran Naji, Imene Zerizer -- Direct visualization of therapeutic radionuclides distribution using nuclear medicine imaging: i-131 in metastatic thyroid carcinoma / Ho Young Lee ... [et al.] -- Imaging drug delivery to the cns using translational positron emission tomography studies / Chi-Ming Lee, Katarina Varns.
  • 2013 Wiley
    edited by Dennis Douroumis and Alfred Fahr.
    Self-assembled delivery vehicles for poorly water-soluble drugs : basic theoretical considerations and modeling concepts / Silvio May and Alfred Fahr -- Liposome as intravenous solubilizers for poorly water soluble drugs / Peter van Hoogevest, Mathew Leigh and Alfred Fahr -- Drug solubilization and stabilization of cyclodextrin drug carriers / Thorsteinn Loftsson and Marcus Eli Brewster -- Solid lipid nanoparticles for drug delivery / Sonja Joseph and Heike Bunjes -- Polymeric drug delivery systems for encapsulating hydrophobic drugs / Naveed Ahmed, C.E. Mora-Heurtas, Chiraz Jaafar-Maalej, Hatem Fessi and Abdelhamid Elaissari -- Polymeric drug delivery systems for encapsulating hydrophobic drugs / Dagmar Fischer -- Development of self-emulsifying drug delivery systems (SEDDS) for oral ioavailability enhancement of poorly soluble drugs / Dimitrios G. Fatouros and Anette Müllertz -- Novel top-down technologies : effective production of ultra-fine drug nanocrystals / Cornelia. M. Keck, S. Kobierski, R. Mauludin and Rainer H. Müller -- Nanosuspensions with enhanced drug dissolution rates of poorly water-soluble drugs / Dennis Douroumis -- Microemulsions for drug solubilization and delivery / X.Q. Wang and Qiang Zhang -- Enhancing drug solubility and bioavailability using hot melt extruded solid dispersions / Shu Li, David S. Jones and Gavin P. Andrews -- Penetration enhancers, solvents and the skin / Jonathan Hadgraft and Majella E. Lane -- Dendrimers for enhanced drug solubilization / Narendra K. Jain and Rakesh K. Tekade -- Polymeric micelles for the delivery of poorly soluble drugs / Swati Biswas, Onkar S. Vaze, Sara Movassaghian and Vladimir P. Torchilin -- Nanostructured silicon-based materials as a drug delivery system for water insoluble drugs / Vesa-Pekka Lehto, Jarno Salonen, Helder Santos and Joakim Riikonen -- Micro- and nanosizing of poorly soluble drugs by grinding techniques / Stefan Scheler -- Enhanced solubility of poorly soluble drugs via spray drying / Cordin Arpagaus, David Rütti and Marco Meuri.
  • 2014 Springer Protocols
    edited by Kewal K. Jain, Jan PharmaBiotech, Basel, Switzerland.
    Current Status and Future Prospects of Drug Delivery Systems -- A Method for Screening Mitochondrial Fusogenic Envelopes for use in Mitochondrial Drug Delivery -- Ultrasound-directed, Site-specific Gene Delivery -- Synthesis of Thermoresponsive Polymers for Drug Delivery -- Recombinant Stem Cells as Carriers for Cancer Gene Therapy -- Microfluidic-based Manufacture of siRNA-lipid Nanoparticles for Therapeutic Applications -- Microneedle-iontophoresis Combinations for Enhanced Transdermal Drug Delivery -- Polymer Nanoparticle-based Controlled Pulmonary Drug Delivery -- Antibody Labeling with Radioiodine and Radiometals -- Self Assembling Peptide -based Delivery of Therapeutics for Myocardial Infarction -- Applications of Chitosan Nanoparticles in Drug Delivery -- A Method for Evaluating Nanoparticle Transport through the Blood Brain Barrier in vitro -- Bacterial Systems for Gene Delivery to Systemic Tumours -- Synthesis of a Smart Nanovehicle for Targeting Liver -- Intranasal Delivery of Chitosan-siRNA Nanoparticle Formulation to the Brain -- Intrathecal Delivery of Analgesics.
  • 2013 Springer
    edited by Jorge Coelho.
    Polymers in Drug Delivery: Concepts, Developments and Potential / Rongjun Chen -- Amphiphilic Molecules in Drug Delivery Systems / Salomé dos Santos, Bruno Medronho -- Sizing Nanoparticles in Liquids: An Overview of Methods / Margarida Figueiredo -- Nanoparticles for Oral Delivery of Insulin / Antonio J. Ribeiro, Raquel Seiça -- Bioartificial Pancreas: In the Road to Clinical Application / Joana Crisóstomo, Jorge F. J. Coelho -- Cationic Liposome-Based Systems for Nucleic Acid Delivery: From the Formulation Development to Therapeutic Applications / Henrique Faneca, Ana Luísa Cardoso -- Biomaterial-Based Vectors for Targeted Delivery of Nucleic Acids to the Nervous System / Ana Paula Pêgo, Hugo Oliveira -- Biofabrication of Hydrogel Constructs / Rúben F. Pereira, Henrique A. Almeida -- The Warburg Effect Is a Guide to Multipurpose Cancer Therapy Including Trace Element Delivery / Anatoliy V. Popov, Leonid G. Menchikov -- In Silico Research in Drug Delivery Systems / André Filipe Ferreira, Rodrigo José Lopes -- The Importance of Controlled/Living Radical Polymerization Techniques in the Design of Tailor Made Nanoparticles for Drug Delivery Systems / Nuno Rocha, Patrícia Mendonça, Joana R. Góis.
  • 2011 CRCnetBASE
    Vasant V. Ranade, John B. Cannon.
    "Drug delivery technologies represent a vast and vital area of research and development in pharmaceutics. The demand for innovative drug delivery systems continues to grow, and this growth drives a variety of new developments. Building on the foundation provided by the second edition, Drug Delivery Systems, Third Edition covers the latest in research, development, and regulations in industry and academia.The third edition of this popular book provides a comprehensive review of the latest research and development on drug delivery systems (including liposomal, transmucosal, transdermal, oral, polymeric, and monoclonal antibody directed delivery); it also contains a new chapter on nanoscience and technology for drug delivery along with cutting-edge business intelligence and strategies. These topics are spread into five sections: Site-specific drug delivery Polymers and implantable drug delivery systems Oral drug delivery Transdermal, transmucosal, ocular, and miscellaneous drug delivery systems Regulatory considerations and global outlook Written in a straightforward, clear, and concise manner, the authors provide a global perspective on current and future advances and market opportunities. The book answers the need for comprehensive information in a single resource for anyone venturing into this area of drug development and who desires an overview of the field, with extensive guidance on where to gain more information. Each chapter provides a table of marketed and investigational products, with numerous practical examples; the book also provides readers with a multitude of possible drug delivery systems that can be used to improve therapeutics, along with global and regulatory perspectives"--Provided by publisher.
  • 2008 Springer Protocols
    edited by Kewal K. Jain.
    Drug delivery systems--an overview / Kewal K. Jain -- The role of the adeno-associated virus capsid in gene transfer / Kim M. Van Vliet ... [et al.] -- Delivering small interfering RNA for novel therapeutics / Patrick Y. Lu and Martin C. Woodle -- Catheters for chronic administration of drugs into brain tissue / Michael Guarnieri, Benjamin S. Carson, Sr., and George I. Jallo -- Transdermal drug delivery systems : skin perturbation devices / Marc B. Brown ... [et al.] -- Controlling the release of proteins/peptides via the pulmonary route / Sunday A. Shoyele -- Engineering protein particles for pulmonary drug delivery / Sunday A. Shoyele -- 2B-Trans technology : targeted drug delivery across the blood-brain barrier / Pieter J. Gaillard and Albertus G. de Boer -- Drug delivery in cancer using liposomes / Crispin R. Dass -- pH-responsive nanoparticles for cancer drug deliery / Youqing Shen ... [et al.] -- Extended-release oral drug delivery technologies : monolithic matrix systems / Sandip B. Tiwari and Ali R. Rajabi-Siahboomi.
  • 2014 Springer
    Margareta Hammarlund-Udenaes, Elizabeth C.M. de Lange, Robert G. Thorne, editors.
    This book describes the different approaches for drug delivery to the brain with an emphasis on the physiology of the blood-brain barrier (BBB) and the governing principles and concepts for drug delivery across the BBB. It contains cutting-edge methods for studying drug delivery and administering drugs into the brain. The book also explores different approaches for predicting human brain concentrations as well as the influence of disease and drug industry perspectives. In addition to wide-ranging coverage of physiological concepts relevant to central nervous system (CNS) drug delivery, a detailed review of brain structure, function, blood supply and fluids is also provided. In each chapter, descriptions of future challenges and unresolved questions are combined with points for discussion. This unique combination of material makes this book a valuable resource for students and for established academic and industry scientists looking to learn about state-of-the-art drug delivery research. It is also a source for stimulating new ideas among experts already performing CNS drug delivery research or working in related areas. Margareta Hammarlund-Udenaes (Ph.D.) is a Professor in Pharmacokinetics and Pharmacodynamics (PK/PD) at Uppsala University and the Head of the Translational PK/PD Group. Her research is focused on studying pharmacokinetic aspects of BBB transport of drugs in relation to CNS effects, and it has led to the development of new concepts and methods within the BBB transport area, focusing on unbound drug relationships. Elizabeth C.M. de Lange (Ph.D.) is Head of the Target Site Equilibration Group at the Division of Pharmacology of the Leiden Academic Center for Drug Research (LACDR). Her research program focuses on the development of generally applicable predictive PK/PD models on CNS drugs using advanced in vivo animal models and mathematical modeling techniques, with a number of recent successes. Robert G. Thorne (Ph.D.) is an Assistant Professor in Pharmaceutical Sciences at the University of Wisconsin-Madison School of Pharmacy. He was previously a research scientist and faculty member in the Department of Physiology & Neuroscience at the New York University School of Medicine. His research focuses on diffusive and convective transport within the CNS and the development, refinement and optimization of strategies for delivering biologics into the brain.
  • 2010 Springer Protocols
    edited by Kewal K. Jain.
    An overview of drug delivery to the CNS / K.K. Jain -- Receptor-mediated transport of drugs across the BBB / J.-M. Feng, P.C.W. Lui and J.Y. Li -- Disruption of blood-brain barrier by focused ultrasound for targeted drug delivery to the brain / N. Vykhodtseva -- Prediction of blood-brain barrier penetration by drugs / K. Lanevskij ... [et al.] -- Intraparenchymal delivery and its discontents / R. Raghavan -- Intrathecal drug delivery by implanted pumps / S. Belverud, A. Mogilner and M. Schulder -- Intracarotid drug delivery: Revisiting the past or looking into the future / S. Joshi -- Vesicular systems for intranasal drug delivery / I.A. Alsarra ... [et al.] -- Convection-enhanced drug delivery and monitoring in a rat model / Y. Mardor and Z. Ram -- Intrathecal delivery of stem cells to the spinal cord / B. Neuhuber and I. Fischer -- CNS delivery of peptides across the BBB using the dual-artery in situ brain perfusion model / K.A. Witt ... [et al.] -- An engineered peptide compound platform technology incorporating angiopep for crossing the BBB / R. Gabathuler -- Adeno-associated virus mediated gene therapy in ischemic stroke / Y. Wang, F. Yuan and G.-Y. Yang -- Use of mesenchymal stem cells for gene delivery to intracranial glioma / S.-S. Jeun ... [et al.] -- Convection-enhanced drug delivery to the brain / D. Ding ... [et al.].
  • 2005 CRCnetBASE
    [editors] Tapash K. Ghosh, William R. Pfister.
  • 2014 ScienceDirect
    edited by Atta-ur-Rahman, FRS, Honorary Life Fellow, Kings College, University of Cambridge, UK and Muhammad Iqbal Choudhary, H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Pakistan.
  • 2011 Springer Protocols
    edited by Seetharama D. Satyanarayanajois.
    Virtual screening for lead discovery / Yat T. Tang and Garland R. Marshall -- Computer-aided drug discovery and development / Shuxing Zhang -- Using active site mapping and receptor-based pharmacophore tools : prelude to docking and de novo/fragment-based ligand design / Ashutosh Tripathi, J. Andrew Surface, and Glen E. Kellogg -- Methods for evaluation of structural and biological properties of antiinvasive natural products / Mudit Mudit [and others] -- Solid-phase peptide synthesis using microwave irradiation / Justin K. Murray, Jennifer Aral, and Les P. Miranda -- Fluorescent and lanthanide labeling for ligand screens, assays, and imaging / Jatinder S. Josan [and others] -- DNA-directed assembly microarray for protein and small molecule inhibitor screening / Ng Jin Kiat [and others] -- Selection of peptide ligands for human placental transcytosis systems using in vitro phage display / Saleem Basha, Shruthi Vaidhyanathan, and GIovanni M. Pauletti -- Optimization of the tetrazolium dye (MTT) colorimetric assay for cellular growth and viability / Paul W. Sylvester -- Imaging NF-KB signaling in mice for screening anticancer drugs / Delira Robbins and Yunfeng Zhao -- Evaluation of anticancer agents using flow cytometry analysis of cancer stem cells / Vineet Gupta, Qian-Jin Zhang, and Yong-Yu Liu -- Chemical screening with zebrafish embryos / Hanbing Zhong and Shuo Lin -- iTRAQ labeling coupled with LC-MALDI mass spectrometry for monitoring temporal response of colorectal cancer cells to butyrate treatment / Hwee Tong Tan [and others] -- Heterotypic cell adhesion assay for the study of cell adhesion inhibition / Seetharama D. Satyanarayanajois, Sharon Ronald, and Jining Liu -- Evaluation of antibacterial activity of proteins and peptides using a specific animal model for wound healing / Ramar Perumal Samy [and others] -- In vitro immunogenicity risk assessment of therapeutic proteins in preclinical setting / Punett Gaitonde and Sathy V. Balu-Iyer.
  • 2013 Springer
    Gerhard Klebe.
    Unique work on structure-based drug design, covering multiple aspects of drug discovery and development. Fully colored, many images, computer animations of 3D structures (these only in electronic form). Makes the spatial aspects of interacting molecules clear to the reader, covers multiple applications and methods in drug design. Structures by mode of action, no therapeutic areas. Of high relevance for academia and industrial research. Focus on gene technology in drug design, omics-technologies computational methods experimental techniques of structure determinationmultiple examples on mode of action of current drugs, ADME-tox properties in drug development, QSAR methods, combinatorial chemistry, biologicals, ribosome, targeting protein-protein interfaces.
  • 2011 Springer
    Hans Gerhard Vogel, Jochen Mass, Alexander Gebauer (eds.).
    Section A. Introduction -- section B. Clinical pharmacokinetics -- section C. Human studies in clinical pharmacology -- section D. Regulations.
  • 2008 Springer
    H. Gerhard Vogel (ed.).
  • 2006 Springer
    H. Gerhard Vogel (ed.) ; Franz Jakob Hock, Jochen Maas, Dieter Mayer (co-editors).
    Section I, Safety pharmacology: -- Introduction to safety pharmacology -- Status of safety pharmacology and present guidelines -- Central nervous system (CNS) safety pharmacology studies -- Methods in cardiovascular safety pharmacology -- Safety pharmacology of drugs for the urinary tract -- Respiratory function assays in safety pharmacology -- Metabolism pharmacology -- Peripheral nervous system -- Safety of intravenous and inhalation anesthetics -- Side effects of central analgesic drugs -- Safety pharmacology of antiinflammatory drugs -- Safety pharmacology of drugs with osteoarthritis-related activity -- Safety pharmacology of blood constituents -- Ocular toxicity tests -- Assays in endocrine safety pharmacology -- Safety assays in skin pharmacology -- Magnetic resonance imaging in pharmaceutical safety assessment -- Section II, Safety pharmacokinetics: -- Introduction -- Physicochemical properties -- In-silico ADME modeling -- Absorption-in vitro tests-cell based -- Absorption-in vitro tests-non cell based -- Distribution-in vitro tests-protein binding -- Perfused organs -- Metabolism studies in vitro and in vivo -- Distribution-across barriers -- Drug-drug interaction-enzyme induction -- Drug-drug interaction-enzyme inhibition -- Absorption -- In vivo distribution -- Distribution-in vivo-other methods -- Bioanalytical assays-Toxicokinetics -- Bioanalytical assays-liquid chromatography coupled to tandem spectrometry -- Bioanalytical assays-gas chromatography -- Bioanalytical assays-RIA/EIA -- Clinical studies-typical designs -- Pharmacogenomics in DME -- Typical PK/PD approaches -- Population kinetics in drug development -- Section III, Safety toxicology: -- Introduction -- International guidelines for the development of pharmaceutical compounds -- General toxicity -- In silico methods -- Alternative methods for carcinogenicity testing -- Genotoxicity -- Reproductive toxicology -- Application of toxicoproteomics in profiling drug effects.
  • 2005 Wiley
    edited by Shayne Cox Gad.
    Introduction. Drug discovery in the 21st century -- ch. 1. Natural products / Charles B. Spainhour -- ch. 2. Cancer cell proteomics using molecular aptamers / Weihong Tan ... [et al.] -- ch. 3. Molecular similarity methods and QSAR models as tools for virtual screening / Jürgen Bajorath -- ch. 4. Systems biology : applications in drug discovery / Sean Ekins ...[et al.] -- ch. 5. High throughput flow cytometry / Larry A. Sklar ... [et al.] -- ch. 6. Combining NMR spectral information with associated structural features to form computationally nonintensive, rugged, and objective models of biological activity / Richard D. Beger, Dan A. Buzatu, and Jon G. Wilkes -- ch. 7. Using Microsoft Excel as a laboratory data management tool / A. Erik Rubin, Mark F. Russo, and William Neil -- ch. 8. Age of regulation / Sandy Weinberg and Gerald J. Whartenby -- ch. 9. Simultaneous screening of multiple cell lines using the CellCard system / Oren E. Beske -- ch. 10. Protein X-ray crystallography in drug discovery / Peter Nollert ... [et al.] -- ch. 11. Biological and chemistry assays available during drug discovery and developability assessment / Duane B. Lakings -- ch. 12. Strategies and methods in monitoring and targeting protein-protein interactions / Arianna Loregian and Giorgio Palù -- ch. 13. High-throughput screening : evolution of technology and methods -- Martyn N. Banks ... [et al.] -- ch. 14. Metal-enhanced fluorescence : application to high-throughput screening and drug discovery / Kadir Aslan ... [et al.] -- ch. 15. Methods for the design and analysis of replicate-experiment studies to establish assay reproducibility and the equivalence of two potency assays / Brian J. Eastwood ... [et al.] -- ch. 16. Coupled luminescent methods in drug discovery : 3-minute assays for cytotoxicity and phosphatase activity / Michael J. Corey and Robert J. Kinders -- ch. 17. Design and pharmaceutical applications of prodrugs / Tomi Järvinen ... [et al.] -- ch. 18. GABA and glutamate receptor ligands and their therapeutic potential in CNS disorders / Ulf Madsen ... [et al.] -- ch. 19. Cardiac sarcolemmal ATP-sensitive potassium channel antagonists : novel ischemia-selective antiarrhythmic agents / George E. Billman -- ch. 20. Factors influencing the efficacy of mediator-specific anti-inflammatory, glucocorticoid, and anticoagulant therapies for sepsis / Peter C. Minneci ... [et al.] -- ch. 21. Combinatorial chemistry in the drug discovery process / Nathan T. Ross, Brian R. McNaughton, and Benjamin L. Miller -- ch. 22. Herbal medicines and animal models of gastrointestinal diseases / C.H. Cho and J.K.S. Ko -- ch. 23. Endocrine and metabolic agents / Brian L. Furman -- ch. 24. Respiratory viruses / Paul D. Olivo -- ch. 25. Strategies in the design of antiviral drugs / Erik De Clercq and Piet Herdewijn -- ch. 26. Protein kinase inhibitors in drug discovery / Keykavous Parang and Gongqin Sun -- ch. 27. RNA-based therapies / Steve Pascolo -- ch. 28. Novel imaging agents for molecular MR imaging of cancer / Dmitri Artemov and Zaver M. Bhujwalla -- ch. 29. Targets and approaches for cancer drug discovery / Susan L. Mooberry.
  • 2010 Springer
    Haiyong Han, Paul Grippo, editors.
    1. Drug evaluations in pancreatic cancer culture systems -- 2. Mouse xenograft models for drug discovery in pancreatic cancer -- 3. Flourescent metastatic mouse models of pancreatic cancer for drug discovery -- 4. A new preclinical paradigm for pancreas cancer -- 5. Zebrafish as a biological system for identifying and validating therapeutic targets and compounds -- 6. Gene expression arrays in pancreatic cancer drug discovery research -- 7. Using array comparative genomic hybridization of pancreatic cancer samples to map interesting regions for target gene identification -- 8. The application of high-throughput RNAi in pancreatic cancer target discovery and drug development -- 9. MicroRNA a profiling and its application in drug discovery in pancreatic cancer -- 10. Methylation detection and epigenomics in pancreatic cancer -- 11. Tissue microarray applications in drug discovery for pancreatic cancer -- 12. Proteomic analysis of blood and pancreatic juice -- 13. Applications of antibody-lectin sandwich arrays (ALSA) to pancreatic cancer diagnostics and drug discovery -- 14. The development of pharmacodynamic endpoint models for evaluation of therapeutic in pancreatic cancer -- Index.
  • 2008
    Bonnie Snow.
    Status: Not Checked OutLane Catalog Record
    Guide to the guide -- Drug identification : variations in drug nomenclature and their impact on information retrieval -- Government regulations affecting drugs and the pharmaceutical industry -- Evaluating drug information sources and developing a search protocol -- Pharmacology and therapeutics reference sources -- Reference sources for adverse drug reactions and interactions -- Drug analysis, formulation, and compounding reference sources -- Compiling background bibliography using online resources -- Competitive intelligence resources : drugs-in-development directories, protocol registries, and pharmaceutical business intelligence : companies, products, and marketplace research sources.
  • 2012
    Status: Not Checked OutLane Catalog Record
    Drug products alphabetically organized and cross-referenced by U.S. and Canadian brand names and index terms; information on brand names, usage, dosage, pregnancy considerations, warnings, adverse reactions, and drug interactions.
  • 2011
    seniors editors: Charles F. Lacy, Lora L. Armstrong, Morton P. Goldman, Leonard L. Lance.
    Status: Not Checked OutLane Catalog Record
    Presents alphabetically arranged entries of drug products providing information on brand names, usage, dosage, pregnancy considerations, warnings, adverse reactions, and drug interactions.
  • 2010
    Status: Not Checked OutLane Catalog Record
  • 2011
    senior editor, Diedra L. Bragalone.
    Status: Not Checked OutLane Catalog Record
  • 1983-2014.
    the Mediphor Editorial Group, Division of Clinical Pharmacology, Stanford University School of Medicine ; editor, Richard J. Mangini ; editorial board, Terrence F. Blaschke, Stanley N. Cohen, David S. Tatro.
    Status: Not Checked OutLane Catalog Record
    Also available: Print – 1983-2015 including updates
  • 2002-2013 (including updates)
    editor, David S. Tatro.
    Status: Not Checked OutLane Catalog Record
    Also available: Print – 2002-2013 including updates
  • v. 1-2, 1972-1974.
    Vasta, Bruno M.
    Status: Not Checked OutLane Catalog Record
    v. 1. 1967-1970 -- v. 2. 1970-1971.
  • 2011 Springer
    Stephen C. Piscitelli, Keith A. Rodvold, Manjunath P. Pai, editors.
    Introduction to Drug-Drug Interactions -- Mechanisms of Drug Interactions I: Absorption, Metabolism, and Excretion -- Mechanisms of Drug Interactions II: Transport Proteins -- Drug-Food Interactions -- Interactions Between Herbs and Antiinfective Medications -- Drug-Cytokine Interactions -- Beta-Lactam Antibiotics -- Macrolides, Azalides, and Ketolides -- Quinolones -- Glycopeptides, Lipopeptides, and Lipoglycopeptides -- Miscellaneous Antibiotics -- Drugs for Tuberculosis -- Drug Interactions with Antiretrovirals for HIV Infection -- Non-HIV Antiviral Agents -- Antifungal Agents -- Antimalarial Agents -- Antiprotozoal and Anthelmintic Agents -- Drug Interaction Considerations Throughout Drug Development -- Probe Cocktail Studies -- Design and Data Analysis in Drug Interaction Studies.
  • 2010 Springer
    edited by William D. Figg, Cindy H. Chau, Eric J. Small.
    Cell Biology of Prostate Cancer and Molecular Targets / Martin E. Gleave, Michael E. Cox, and Yuzhuo Wang -- Part I. Hormone Therapy. Luteinizing Hormone-Releasing Hormone and its Agonistic, Antagonistic, and Targeted Cytotoxic Analogs in Prostate Cancer / Andrew V. Schally and Norman L. Block ; Nuclear Receptor Coregulators: Promising Therapeutic Targets for the Treatment of Prostate Cancer / Hannelore V. Heemers and Donald J. Tindall ; Androgens and Prostate Cancer / Douglas K. Price and Ann W. Hsing ; Androgen Receptor Biology in Prostate Cancer / Edward P. Gelmann ; Androgen Receptor Antagonists / Howard C. Shen, Mary-Ellen Taplin, and Steven P. Balk ; 5-Alpha Reductase Inhibitors in Prostate Cancer / Zoran Culig ; Adrenal Androgen Synthesis Inhibitor Therapies in Castration-Resistant Prostate Cancer / Terence W. Friedlander and Charles J. Ryan ; Androgen Deprivation Therapy / Nima Sharifi ; Pharmacogenetics of the Androgen Metabolic Pathway / Francine Zanchetta Coelho Marques, and Juergen K.V. Reichardt -- Part II. Chemotherapy. Mitoxantrone / Patricia Halterman, Nicholas J. Vogelzang, Alireza Farabishahadel, and Oscar B. Goodman Jr. ; Docetaxel / Courtney K. Phillips and Daniel P. Petrylak ; Beyond Docetaxel: Emerging Agents in the Treatment of Advanced Prostate Cancer / Jonathan Rosenberg ; Platinum Agents in Prostate Cancer / Ashley Brick, Junyang Niu, Jiaoti Huang, and William K. Oh ; Clinical Pharmacology and Pharmacogenetics of Chemotherapy in Prostate Cancer / Tristan M. Sissung and William D. Figg ; Microtubule Targeting Agents / Antonio Tito Fojo and David E. Adelberg -- Part III. Angiogenesis. Principles of Antiangiogenic Therapy / Cindy H. Chau and William D. Figg ; Bevacizumab in Advanced Prostate Cancer / Aymen A. Elfiky and William Kevin Kelly ; Thalidomide and Analogs / Erin R. Gardner, Giuseppe Di Lorenzo, and William D. Figg ; Investigational Angiogenesis Inhibitors / Jeanny B. Aragon-Ching and William Dahut ; Pharmacogenetics of Angiogenesis / Guido Bocci, Giuseppe Pasqualetti, Antonello Di Paolo, Francesco Crea, Mario Del Tacca, and Romano Danesi -- Part IV. Bone Metastasis. Pathophysiology of Prostate Cancer Bone Metastasis / Evan T. Keller and Christopher L. Hall ; Radiopharmaceuticals / Oliver Sartor and Damerla R. Venugopal ; Bisphosphonates for Prevention and Treatment of Bone Metastases / Philip J. Saylor and Matthew R. Smith ; Endothelin Receptors as Therapeutic Targets in Castration-Resistant Prostate Cancer / Joel B. Nelson ; Calcitriol and Vitamin D Analogs / Ana R. Jensen, Russell Z. Szmulewitz, Tomasz M. Beer, and Edwin M. Posadas -- Part V. Immunotherapy. Cancer Immunology, Immunotherapeutics, and Vaccine Approaches / Ravi A. Madan, James L. Gulley, Jackie Celestin, Philip M. Arlen, and Jeffrey Schlom ; Sipuleucel-T (APC8015): Active Cellular Immunotherapy for Advanced Metastatic Castration-Resistant Prostate Cancer / Celestia S. Higano and Mark W. Frohlich ; GM-CSF Gene-Transduced Prostate Cancer Vaccines: GVAX / Lalit R. Patel and Jonathan W. Simons ; CTLA-4 Blockade for Prostate Cancer Treatment / Andrea L. Harzstark and Lawrence Fong -- Part VI. Prevention. Prostate Cancer Chemoprevention Strategies / Howard L. Parnes, Margaret G. House, and Joseph A. Tangrea ; Diet and Prostate Cancer Incidence, Recurrence, and Progression Risk / June M. Chan and Erin L. Richman ; Inflammation as a Target in Prostate Cancer / Marshall Scott Lucia, James R. Lambert, Elizabeth A. Platz, and Angelo M. De Marzo -- Part VII. Drug Development. Challenges for the Development of New Agents in Prostate Cancer / Ajjai S. Alva, Deborah A. Bradley, and Maha Hussain ; FDA Approval of Prostate Cancer Treatments / Yang-Min Ning, Ramzi N. Dagher, and Richard Pazdur ; Applications of Proteomics in Prostate Cancer / Mitchell Gross, Edward Macrohon Nepomuceno, and David B. Agus.
  • 2005 Springer
    edited by Corina Ionescu and Mino R. Caira.
  • 2011 Springer
    by Siamak Cyrus Khojasteh, Harvey Wong, Cornelis E.C.A. Hop.
    1. Pharmacokinetics -- 2. Drug Metabolizing Enzymes -- 3. Oral Absorption -- 4. Transporters -- 5. Metabolism-Based Drug Interactions -- 6. Biotransformation and Bioactivation -- 7. Prediction of Human Pharmacokinetics -- 8. Advances in Bioanalysis as It Relates to ADME -- 9. ADME Properties and Their Dependence on Physicochemical Properties -- 10. In Silico ADME Tools -- 11. Approved Drugs -- 12. Chemical Nomenclature.
  • 2005 Springer Protocols
    edited by Lawrence H. Lash.
    Renal cytochrome P450s and flavin-containing monooxygenases : potential roles in metabolism and toxicity of 1,3-butadiene, trichloroethylene, and tetrachloroethylene / Adnan A. Elfarra -- Experimental approaches for the study of cytochrome P450 gene regulation / Hollie I. Swanson ... [et al.] -- Insulin and growth factor signaling : effects on drug metabolizing enzymes / Sang K. Kim, Kimberly J. Woodcroft, and Raymond F. Novak -- Catalytic function and expression of glutathione transferase zeta / Philip G. Board, M.W. Anders, and Anneke C. Blackburn -- Glucuronidation of fatty acids and prostaglandins by human udp glucuronosyltransferases / Anna Radominska-Pandya, Joanne M. Little and Arthur Bull -- Transcriptional regulation of UDP-glucuronosyltransferases / Anna Radominska-Pandya, Peter I. Mackenzie, and Wen Xie -- Phenotypic and genotypic characterization of n-acetylation / Craig K. Svensson and David W. Hein -- Methods and approaches to study metabolism and toxicity of acetaminophen / Sam A. Bruschi -- Modulation of drug metabolism and antiviral therapies / Bernhard H. Lauterburg -- Modulation of thiols and other low-molecular-weight cofactors : effects on drug metabolism and disease susceptibility / Charles V. Smith -- Multidrug resistance proteins and hepatic transport of endo- and xenobiotics / Phillip M. Gerk and Mary Vore -- Structural determinants of folate and antifolate membrane transport by the reduced folate carrier / Wei Cao and Larry H. Matherly -- Glutathione transport in the kidneys : experimental models, mechanisms, and methods / Lawrence H. Lash -- Human cytosolic sulfotransferases : properties, physiological functions, and toxicology / Charles N. Falany.
  • 2011 Springer
    Uday B. Kompella, Henry F. Edelhauser, editors.
    This comprehensive volume discusses approaches for a systematic selection of delivery systems for various classes of therapeutic agents including small molecule, protein, and nucleic acid drugs. Specific topics covered in this book include: Solution, suspension, gel, nanoparticle, microparticle, and implant dosage forms; Refillable and microneedle devices; Intravitreal, suprachoroidal, intrascleral, transscleral, systemic, and topical routes of delivery; Physical methods including iontophoresis for drug delivery; Rational selection of routes of administration and delivery systems; Noninvasive and continuous drug monitoring; Clinical endpoints and regulatory path to drug product development; Emerging and existing drugs and drug targets.
  • 2006 CRCnetBASE
    edited by Donald C. Monkhouse, Charles F. Carney, James L. Clark.
  • 2006
    edited by Donald C. Monkhouse, Charles F. Carney, James L. Clark.
    Status: Not Checked OutLane Catalog Record
  • 2001 CRCnetBASE
    Nikolaos A. Botsoglou, Dimitrios J. Fletouris.
  • 2009 Springer
    Kapil Mehta, Zahid H. Siddik, editors ; foreword by Susan E. Bates.
    Multidrug Resistance Mediated by MDR-ABC Transporters / Gergely Szakács ... [et al.] -- Metastasis and Drug Resistance / Dominic Fan ... [et al.] -- The Role of Autophagy and Apoptosis in the Drug Resistance of Cancer / Tomohisa Yokoyama ... [et al.] -- Mechanisms of Resistance to targeted Tyrosine Kinase Inhibitors / Stacey J.Baker, E. Premkumar Reddy -- Targeting Transglutaminase-2 to overcome Chemoresistance in Cancer Cells / Kapil Mehta, Jansina Y. Fok -- Extracellular Matrix-Mediated Drug Resistance / P.S. Hodkinson, Tariq Sethi -- Oxidative Stress and Drug Resistance in Cancer / Dunyaporn Trachootham, Wan Zhang, Peng Huang -- Nuclear Factor-kB and Chemoresistance / Ajaikumar B.Kunnumakkara, Preetha Anand, Bharat B. Aggarwal -- Drug Resistance and the Tumor Suppressor p53 : The Paradox of Wild-Type Genotype in Chemorefractory Cancers / Zahid H. Siddik -- Resistance to Differentiation Therapy / Bulent Ozpolat -- MicroRNAs and Drug Resistance / Elisa Barbarotto, George A. Calin -- Molecular Signatures of Drug Resistance / Melissa A. Troester, Jason I. Herschkowitz, Katherine A. Hoadley -- Assessment of Drug Resistance in Anticancer Therapy by Nuclear Imaging / Natalie Charnley, Catharine West, Pat Price -- Overcoming Drug Resistance by Phytochemicals / Marion M. Chan, Dunne Fong.
  • 2013 Springer
    Alicia Ponte-Sucre, Emilia Díaz, Maritza Padrón-Nieves, editors.
  • 2009 Springer Protocols
    edited by Jean-Charles Gautier.
    Developing Combination Drugs in Preclinical Studies / Alberto Lodola -- Preclinical Evaluation of Juvenile Toxicity / Paul C. Barrow, Stéphane Barbellion, Jeanne Stadler -- Necropsy and Sampling Procedures in Rodents / Laurence Fiette, Mohamed Slaoui -- Histopathology Procedures: From Tissue Sampling to Histopathological Evaluation / Mohamed Slaoui, Laurence Fiette -- Principles and Methods of Immunohistochemistry / José A. Ramos-Vara -- Tissue Microarrays and Digital Image Analysis / Denise Ryan, Laoighse Mulrane, Elton Rexhepaj, William M. Gallagher -- Micronucleus Assay and Labeling of Centromeres with FISH Technique / Ilse Decordier, Raluca Mateuca, Micheline Kirsch-Volders -- The Use of Bacterial Repair Endonucleases in the Comet Assay / Andrew R. Collins -- Manual Whole-Cell Patch-Clamping of the HERG Cardiac K+ Channel / Xiao-Liang Chen, Jiesheng Kang, David Rampe -- Generation and Analysis of Transcriptomics Data / Philip D. Glaves, Jonathan D. Tugwood -- Protocols of Two-Dimensional Difference Gel Electrophoresis to Investigate Mechanisms of Toxicity / Emmanuelle Com, Albrecht Gruhler, Martine Courcol, Jean-Charles Gautier -- Protocols and Applications of Cellular Metabolomics in Safety Studies Using Precision-Cut Tissue Slices and Carbon 13 NMR / Gabriel Baverel, Sophie Renault, Hassan Faiz, Maha Hage, Catherine Gauthier, Agnès Duplany, Bernard Ferrier, Guy Martin -- Statistical Analysis of Quantitative RT-PCR Results / Richard Khan-Malek, Ying Wang -- Evaluation of Mitochondrial Respiration in Cultured Rat Hepatocytes / Jean-Pierre Marchandeau, Gilles Labbe -- FETAX Assay for Evaluation of Developmental Toxicity / Isabelle Mouche, Laure Malesic, Olivier Gillardeaux -- Evaluation of Embryotoxicity Using the Zebrafish Model / Lisa Truong, Stacey L. Harper, Robert L. Tanguay -- Protocols of In Vitro Protein Covalent Binding Studies in Liver / Jean-François Lévesque, Stephen H. Day, Allen N. Jones -- Utilization of MALDI-TOF to Determine Chemical-Protein Adduct Formation In Vitro / Ashley A. Fisher, Matthew T. Labenski, Terrence J. Monks, Serrine S. Lau -- Utilization of LC-MS/MS Analyses to Identify Site-Specific Chemical Protein Adducts In Vitro / Ashley A. Fisher, Matthew T. Labenski, Terrence J. Monks, Serrine S. Lau / One-Dimensional Western Blotting Coupled to LC-MS/MS Analysis to Identify Chemical-Adducted Proteins in Rat Urine / Matthew T. Labenski, Ashley A. Fisher, Terrence J. Monks, Serrine S. Lau -- Identification of Chemical-Adducted Proteins in Urine by Multi-dimensional Protein Identification Technology (LC/LC-MS/MS) / Matthew T. Labenski, Ashley A. Fisher, Terrence J. Monks, Serrine S. Lau -- Optimization of SELDI for Biomarker Detection in Plasma / Jean-Francois Léonard, Martine Courcol, Jean-Charles Gautier -- Differential Proteomics Incorporating iTRAQ Labeling and Multi-dimensional Separations / Ben C. Collins, Thomas Y. Lau, Stephen R. Pennington, William M. Gallagher -- NMR and MS Methods for Metabonomics / Frank Dieterle, Björn Riefke, Götz Schlotterbeck, Alfred Ross, Hans Senn, Alexander Amberg -- Absolute Quantification of Toxicological Biomarkers by Multiple Reaction Monitoring / Thomas Y. Lau, Ben C. Collins, Peter Stone, Ning Tang, William M. Gallagher, Stephen R. Pennington.
  • 2008
    edited by Hemanta K. Majumder.
    Arsenite resistance in leishmania and possible drug targets / Gaganmeet Singh, K.G. Jayanarayan, Chinmoy S. Dey -- Unique characteristics of the kinetoplast DNA replication machinery provide potential drug targets in trypanosomatids / Dotan Sela ... [et al.] -- Drugs and transporters in kinetoplastid protozoa / Scott M. Landfear -- Selective lead compounds against kinetoplastid tubulin / R.E. Morgan and K.A. Werbovetz -- Fishing for anti-leishmania drugs: principles and problems / Emanuela Handman ... [et al.] -- Sterol 14-demethylase inhibitors for trypanosoma cruzi infections / Frederick S. Buckner -- Histone deacetylases / David Horn -- Targeting glycoproteins or glycolipids and their metabolic pathways for antiparasite therapy / Sumi Mukhopadhyay nee Bandyopadhyay and Chitra Mandal -- DNA topoisomerases of leishmania: the potential targets for anti-leishmanial therapy / Benu Brata Das, Agneyo Ganguly and Hemanta K. Majumder -- Antiparasitic chemotherapy: tinkering with the purine salvage pathway / Alok Kumar Datta, Rupak Datta and Banibrata Sen -- Searching the tritryp genomes for drug targets / Peter J. Myler -- Purine and pyrimidine metabolism in leishmania / Nicola S. Carter ... [et al.].
  • 2008 Springer
    edited by Amanda J. Jenkins ; foreword by Yale H. Caplan.
  • 2013 Springer
    Martin Wehling, editor.
    With people aged 65 years and older currently making up the fastest growing age group throughout the world, the demographic revolution of an aging society will inevitably lead to increased pressure to develop a rationalistic and age-tailored process of diagnosis and treatment among the elderly. As aging people often suffer from several chronic diseases and are being treated with multiple medications concurrently, unwanted drug interactions occur more frequently. Whereas recent approaches have recommended to remove particular drugs from the medication regimen to avoid adverse effects, Drug Therapy for the Elderly underlines both indispensable and dispensable elements of drug treatment, providing the practitioner with:- Background information on the elderly population regarding their needs for particular drugs (with an eye to frailty, co-morbidity patterns, and special sensitivities regarding drug metabolism and excretion)- Practical advice about drug treatment surveillance parameters in the elderly- In-depth discussion of drugs in relation to the elderly with specific diagnoses- Integration of multimorbidity/polypharmacy situations into prioritization schemes- A plan for how to deal with the complexity of polypharmacy situations in a five-minute consultationAn original classification of drugs is proposed by the editor which relates the power of effects, prognostic data, and tolerability to a prioritization scoring system. This approach is the first to not only provide a negative listing, but also integrates positive data into an overall assessment for drugs fit for the aged. Therefore, Drug Therapy for the Elderly serves as a timely reference for a wide array of physicians.
  • 2012 Springer
    Andrew J. Krentz, Bedfordshire & Hertfordshire Postgraduate Medical School, United Kingdom.
    This Adis Pocket Reference presents an up-to-date, succinct, and practical approach to drug therapy for type 2 diabetes.
  • 1976-
    Status: Not Checked OutLane Catalog Record
  • 2011 Springer
    Martin F. Fromm, Richard B. Kim editors.
    Uptake transporters of the human OATP family / Jörg König -- In vitro and in vivo evidence of the importance of organic anion -- transporters (OATs) in drug therapy / Gerhard Burckhardt and Birgitta Christina Burckhardt -- Organic cation transporters (OCTs, MATEs), in vitro and in vivo evidence for the importance in drug therapy / Anne T. Nies et al. -- Role of the intestinal bile acid transporters in bile acid and drug disposition / Paul A. Dawson -- The role of the sodium-taurocholate cotransporting polypeptide (NTCP) and of the bile salt export pump (BSEP) in physiology and pathophysiology of bile formation / Bruno Stieger -- P-glycoprotein: tissue distribution, substrates, and functional consequences of genetic variations / Ingolf Cascorbi -- Importance of P-glycoprotein for drug-drug interactions / Hartmut Gläser -- Multidrug resistance proteins (MRPs, ABCCs): importance for pathophysiology and drug therapy / Dietrich Keppler -- In vitro and in vivo evidence for the importance of breast cancer resistance protein transporters(BCRP/MXR/ABCP/ABCG2) / Henriette E. Meyer zu Schwabedissen and Heyo K. Kroemer -- Molecular mechanisms of drug transporter regulation / Rommel G. Tirona -- In vivo probes of drug transport: commonly used probe drugs -- to assess function of intestinal P-glycoprotein (ABCB1) in humans / Stefan Oswald, Bernd Terhaag, and Werner Siegmund.
  • 2008
    Kazuo Nakamoto, Masamichi Tsuboi, Gary D. Strahan.
    This book provides vital information about drug-DNA interactions. Understand the types of structural and bonding information that can be obtained using specific physico-chemical methods and discover how to design new drugs that are more effective than current treatments and have fewer side effects. Find detailed information about X-ray crystallography, NMR spectroscopy, molecular modeling, and optical spectroscopy such as UV-Visible absorption, fluorescence, circular dichroism (CD), flow linear dichroism (FLD), infrared (IR) and Raman spectroscopy.
  • 2012 Future Med
    editors, Imad Sheiban, Fabrizio D'Ascenzo.
    Drug-eluting stents / Imad Sheiban & Fabrizio D'Ascenzo -- Drug-eluting stents : overview and indications / Fabrizio D'Ascenzo & Imad Sheiban -- Coronary artery stents : approved first-generation drug-eluting stents / Jason R. Foerst, Frank Gruenheck, Malte Kelm & Marc Vorpahl -- Approved drug-eluting stents : second generation / Giampaolo Niccoli & Gregory A. Sgueglia -- Drug-eluting stents in development / Joanne Shannon & Azeem Latib -- Current guidelines for the use of drug-eluting stents / Gill Louise Buchanan & Alaide Chieffo -- Index.
  • 2010
    [editors] James E. Tisdale, Douglas A. Miller.
    Status: Not Checked OutLane Catalog Record
  • 2013 ScienceDirect
    edited by Neil Kaplowitz and Laurie Deleve.
    I. Mechanisms of liver injury. Drug-induced liver injury / Neil Kaplowitz -- Cytochrome P450 activation of toxins and hepatotoxicity / F. Peter Guengerich -- Mechanistic role of acyl glucuronides / Howard Horng, Hilde Spahn-Langguth, and Leslie Z. Benet -- Oxidant stress, antioxidant defense, and liver injury / Mitchell R. McGill and Hartmut Jaeschke -- Hepatotoxicity due to mitochondrial injury / John J. Lemasters -- Mechanisms of cell death and relevance to drug toxicity / Lily Dara, Derick Han, and Neil Kaplowitz -- Role of membrane transport in hepatotoxicity and pathogenesis of drug-induced cholestasis / Bruno Stieger and Gerd A. Kullak-Ublick -- Liver sinusoidal endothelial cells and liver injury / Laurie D. Deleve -- Macrophages and kupffer cells in drug-induced liver injury / Mark Barnes ... [et al.] -- Role of inflammation in drug-induced liver injury / Robert A. Roth and Patricia E. Ganey -- Role of the adaptive immmune system in idiosyncratic drug-induced liver injury / Jack Uetrecht -- Role of tissue repair and death proteins in liver injury / Harihara M. Mehendale -- Genetic factors in the pathogenesis of drug-induced liver injury / Ann K. Daly and Christopher P. Day -- II. Diagnosis and management. Clinical manifestations and management of drug-induced liver diseases / Willis C. Maddrey -- Histopathological evaluationof drug-induced liver disease / David E. Kleiner -- Risk factors for drug-induced liver disease / Raj Vuppalanchi and Maga Chalasani -- Biomarkers for drug-induced liver injury / Paul B. Watkins -- Causality assessment / M. Isabel Lucena ... [et al.] -- III. Hepatotoxicity of specifid drugs. Mechanisms of acetaminophen-induced liver disease / Jack A. Hinson -- Acetaminophen / Laura P. James -- Mechanisms underlying the hepatotoxicity of nonsteroidal antiinflammatory drugs / Urs A. Boelsterli -- Nonsteroidal antiinflammatory drugs and leukotriene receptor antagonists / James H. Kewis and Jonathan G. Stine -- Mechanism, pathology, and clinical presentation of hepatotoxicity of anesthetic agents / J. Gerald Kenna -- Anticonvulsant agents / Munir Pirmohamed and J. Steven Leeder -- Hepatotoxicity of psychotropic drugs and drugs of abuse / Dominique Larrey and Marie-Pierre Ripault -- Hepatotoxicity of antimicrobials and antifungal agents / Richard H. Moseley -- Hepatotoxicity of antitubercular drugs / Sumita Verma and Neil Kaplowitz -- Hepatotoxicity of antiviral agents / Marina Núñez -- Hepatotoxicity of cardiovascular and antidiabetic drugs / Dina Halegoua-De Marzio and Victor J. Navarro -- Cancer chemotherpay / Laurie D. Deleve -- Hepatotoxicity of immunosuppressive drugs / Adrian Reuben -- Hepatotoxicity related to methotrexate / Guruprasad P. Aithal -- Adverse effects of hormones and hormone antagonists on the liver / Shivakumar Chitturi and Geoffrey C. Farrell -- Mushroom poisoning / François Durand and Dominique Valla -- Hepatotoxicity of herbals and dietary supplements / Leonard Seeff, Felix Stickel, and Victor J. Navarro -- Occupational and environmental hepatotoxicity / Keith G. Tolman and Anthony S. Dalpiaz -- Chronic liver disease from drugs / Einar S. Björnsson -- IV. Future directions. Regulatory perspectives / Mark I. Avigan -- Drug-induced liver injury research networks / Robert J. Fontana -- LiverTox / Jay H. Hoofnagle.
  • 2015
    Frederick "Fritz" T. Fraunfelder, Frederick "Rick" W. Fraunfelder, Wiley A. Chambers ; associate editor, Bree Jensvold-Vetsch.
    Status: Not Checked OutLane Catalog Record
  • ScienceDirect
    edited by Jonathan B. Chaires, Michael J. Waring.
    Biophysical approaches -- Chemical and molecular biological approaches -- Enzymology and biological approaches.
    Also available: Print – 2001
  • 2009 Springer
    Patrik Midlöv, Tommy Eriksson, Annika Kragh.
  • 2006 Springer
    edited by H.M. Pinedo and C.H. Smorenburg.
  • 2013 Wellcome Trust
    edited by C. Overy and E.M. Tansey.
  • v. 1-4, 1963. Google Books
    Fulltext Google Books
    Fulltext Google Books
    Fulltext Google Books
    Prepared for the National Advisory Heart Council by May Sherman.
    1. Anticholesteremic, anticoagulant, cholesteremic, fibrinolytic, hemoplastic, and vasoactive agents.--2. Cause and cure of hypertension; drugs and the kidney.--3. Cause and cure of heart failure and shock.
    Also available: Print – v. 1-4, 1963.
  • 2005 Springer
    [edited by] Osamu Suzuki and Kanako Watanabe.
    I. Chapters of general nature. How to handle biological specimens -- Alternative specimens -- Pitfalls and cautions in analysis of drugs and poisons -- Pretreatments of human specimens -- Detection methods -- A computer system for diagnosis of causative drugs and poisons developed by the Japan Poison Information Center (Tokyo) -- Practical use of the poison-net developed by the Japan Poison Information Network (Hiroshima) -- Problems in toxin analysis in emergency medicine -- Analyses of chemical warefare agents and their related compounds -- B. Chapters on specific toxins. Volatile compounds -- Controlled drugs -- Psychopharmaceuticals and hypnotics -- General drugs -- Chemicals of daily necessaries -- Natural toxins and alkaloids -- Pesticides -- Miscellaneous.
  • 2008 Springer
    Walter Krause.
    Male sexual health -- Structure and physiology of the testis -- Introduction -- The spermatozoa -- Sperm motility -- Capacitation and acrosome reaction -- Fertilization of the oocyte -- Testing substances that compromise spermatogenesis and fertility (adapted from Creasy 1997) -- Testosterone production and testosterone effects -- Physiology of erection -- Introduction -- Role of androgens in erection -- Priapism -- Physiology of ejaculation -- Drugs which compromise male sexual health -- Adverse drug effects -- Male sexual health and drugs -- Drugs which compromise testicular function -- Drugs which compromise erectile function -- Drugs which compromise ejaculation -- Database of drugs.
  • 2007 ClinicalKey
    edited by Christof Schaefer, Paul Peters, and Richard K. Miller.
    General commentary on drug therapy and drug risks in pregnancy / Richard K. Miller, Paul W. Peters, and Christoff E. Schaefer -- Specific drug therapies during pregnancy / Mimke Reuvers and Christof Schaefer -- General commentary on drug therapy and drug risk during lactation / Ruth Lawrence and Christof Schaefer -- Specific drug therapies during lactation / Chistof Schaefer and Ruth Lawrence.
  • 2015 ClinicalKey
    edited by Christof Schaefer, Paul Peters, and Richard K. Miller.
  • 2011 Springer
    Maria Sibilia, Christoph C. Zielinski, Rupert Bartsch, Thomas W. Grunt, editors.
    "Growth factor receptors have long been known to drive malignant transformation and cancer progression. The epidermal growth factor receptor (EGFR, ErbB, HER) system is likely the best described membrane receptor tyrosine kinase family in malignant tumors. With implementation of the growth-inhibitory anti-HER-2 antibody trastuzumab (Herceptin) for the treatment of HER-2-positive advanced metastatic breast cancer, a new era has dawned in the therapy of this malignant disease. Unfortunately, trastuzumab-sensitive cancers invariably develop resistance to the antibody after some time. Recent clinical studies have revealed that these refractory tumors are still responsive to inhibition of the HER receptor family using dual HER-1/-2 inhibitors such as lapatinib (Tykerb/Tyverb). Moreover, a multiplicity of novel, improved irreversibly acting small molecular HER tyrosine kinase inhibitors are in the pipeline of many drug developing companies and are being evaluated in the clinical setting."
  • 2012
    Joseph Dumit.
    Status: Not Checked OutLane Catalog Record
    "Every year the average number of prescriptions purchased by Americans increases, as do healthcare expenditures, which are projected to reach one fifth of the U.S. gross domestic product by 2020. In Drugs for Life, Joseph Dumit considers how our burgeoning consumption of medicine and cost of healthcare not only came to be, but came to be taken for granted. For several years, Dumit attended pharmaceutical industry conferences; spoke with marketers, researchers, doctors, and patients; and surveyed the industry's literature regarding strategies to expand markets for prescription drugs. He concluded that underlying the continual growth in medications, disease categories, costs, and insecurity is a relatively new perception of ourselves as inherently ill and in need of chronic treatment. This perception is based on clinical trials that we have largely outsourced to pharmaceutical companies. Those companies in turn see clinical trials as investments and measure the value of those investments by the size of the market they will create. They only ask questions for which the answer is more medicine. Drugs for Life challenges our understanding of health, risks, facts, and clinical trials, the very concepts used by pharmaceutical companies to grow markets to the point where almost no one can imagine a life without prescription drugs."--Provided by publisher.
  • 2005 Springer
    edited by R. Spanagel and K.F. Mann.
  • 2013 ClinicalKey
    [edited by] Lionel H. Opie ; co-editor, Bernard J. Gersh ; foreword by Eugene Braunwald.
    [Beta]-blocking agents / Lionel H. Opie -- Nitrates and newer antianginals / Lionel H. Opie, John D. Horowitz -- Calcium channel blockers / Lionel H. Opie -- Diuretics / Lionel H. Opie, Ronald G. Victor, Norman M. Kaplan -- Inhibitors of the renin-angiotensin-aldosterone system / Lionel H. Opie, Marc A. Pfeffer -- Heart failure / John R. Teerlink, Karen Sliwa, Lionel H. Opie -- Antihypertensive therapies / Lional H. Opie ... [et al.] -- Antiarrhythmic drugs and strategies / Stanley Nattel, Bernard J. Gersh, Lionel H. Opie -- Antithrombotic agents : platelet inhibitors, acute anticoagulants, fibrinolytics, and chronic anticoagulants / Keith A.A. Fox ... [et al.] -- Lipid-modifying and antiatherosclerotic drugs / Antonio M. Gotto Jr., Lionel H. Opie -- Metabolic syndrome, hyperglycemia, and type-2 diabetes / Lionel H. Opie, Juris Meier, John M. Miles -- Which therapy for which condition? / Bernard J. Gersh, Lionel H. Opie.
  • 2009
    [edited by] Lionel H. Opie ; co-editor, Bernard J. Gersh ; foreword by Eugene Braunwald ; original artwork by Jeannie Walker.
    Status: Not Checked OutLane Catalog Record
    [Beta]-blocking agents / Lionel H. Opie, John D. Horowitz -- Nitrates and newer antianginals / Lionel H. Opie, John D. Horowitz -- Calcium channel blockers (calcium antagonists) / Lionel H. Opie -- Diuretics / Lionel H. Opie, Norman M. Kaplan -- Inhibitors of angiotensin-converting enzyme, angiotensin II receptor, aldosterone, and renin / Lionel H. Opie, Marc A. Pfeffer -- Acute and chronic heart failure : positive inotropes, vasodilators, and digoxin / Philip A. Poole-Wilson, Lionel H. Opie -- Antihypertensive drugs / Norman M. Kaplan, Lionel H. Opie -- Antiarrhythmic drugs and strategies / Lionel H. Opie, John P. DiMarco, Bernard J. Gersh -- Antithrombotic agents : platelet inhibitors, anticoagulants, and fibrinolytics / Keith A.A. Fox ... [et al.] -- Lipid-modifying and antiatherosclerotic drugs / Antonio M. Gotto, Jr., Lionel H. Opie -- Metabolic syndrome, hyperglycemia, and Type 2 diabetes / Lionel H. Opie, John M. Miles, Sidney C. Smith, Jr. -- Which therapy for which conditon? / Bernard J. Gersh, Lionel H. Opie.
  • 2006 Springer
    Donald S. Fong, Simon K. Law, Ursula Schmidt-Erfurth, editors.
  • 2015 Ovid
    Gerald G. Briggs, Roger K. Freeman.
  • 2008 Ovid
    Gerald G. Briggs, Roger K. Freeman, Sumner J. Yaffe.
    Also available: Print – 2008
  • 2011 Ovid
    Gerald G. Briggs, Roger K. Freeman, Sumner J. Yaffe.
  • 2005 Springer
    edited by Raphael C. Wong, Harley Y. Tse.
  • 2014 Springer
    Xavier Bosch, Manuel Ramos-Casals, Munther A. Khamashta, editors.
  • Mlodinow, Leonard.
    Status: Not Checked OutLane Catalog Record
  • 2006
    edited by Amar Agarwal.
    Status: Not Checked OutLane Catalog Record
    Anatomy and physiology of the ocular surface / Athiya Agarwal -- Lacrimal system: anatomy and physiology / Alexander V. On and Marc J. Hirschbein -- Anatomy, physiology, and biochemistry of the tear film / Ashok Garg, Amar Agarwal, and C. Sujatha -- Dry eye process and ocular surface disorders / Soosan Jacob and Amar Agarwal -- Evaluation of the dry eye patient / Grant D. Gilliland -- Dry eye secondary to aqueous tear deficiency (Sjögren's syndrome) / Mahmoud M. Ismail, M. Alaa El Danasoury, and Akef El Maghrabi -- Dry eye secondary to increased evaporation / Amar Agarwal and Soosan Jacob -- Allergy- and medication-induced ocular surface disease / W. Barry Lee and Ivan R. Schwab -- Chemical burns and the dry eye / Vatinee Y. Bunya, Christopher J. Rapuano, and Kristin M. Hammersmith -- Keratoplasty: ocular surface corneal transplantation / Roy S. Chuck ... [et al.] -- Keratolimbal allografting / Daniel Böhringer, Rainer Sundmacher and Thomas Reinhard -- Keratoprosthesis / M. Emilia Mulet and Jorge L. Alio -- Surgical options for dry eyes and exacerbating eyelid disorders / Kimberly Cockerham, Orin Zwick, and Glenn C. Cockerham -- Contact lens-induced dry eye / Kenneth Daniels -- Cataract surgery in the dry eye patient / Suresh K. Pandey, Brighu Swamy, and Amar Agarwal -- Refractive surgery and the dry eye patient / Ahmad M. Fahmy and David R. Hardten -- Computer vision syndrome / Suresh K. Pandey and Brighu Swamy. Ocular cicatricial pemphigoid and dry eye syndrome / Vasudha Panday, Kristin M. Hammersmith, and Christopher J. Rapuano -- Tear supplements-artificial tears / Guillermo L. Simón-Castellví ... [et al.] -- Autologous serum drops / Kazuo Tsubota and Murat Dogru -- Restasis-topical cyclosporin A / Renée Solomon ... [et al.] -- Management: miscellaneous modalities / Soosan Jacob ...[et al.] -- Punctal occlusion: plugs, cautery, and suturing / Sanjay V. Patel and H. Kaz Soong -- Amniotic membrane transplantation / Oscar Gris and José L. Güell -- Limbal stem cell disease and management / W. Barry Lee and Ivan R. Schwab --Surgical procedure in stem cell transplantation / Sunita Agarwal and Soosan Jacob -- Large diameter lamellar keratoplasty and stem cell transplantation / Javier Mendicute ... [et al.] --
  • 2015 Springer
    Colin Chan, editor.
    This handbook is a concise, easy-to-read, practical guide that conveys the core knowledge necessary to diagnose, classify, grade, and manage dry eye disease effectively and efficiently. A series of succinct, informative chapters cover the following key topics: definition and classification, epidemiology, office-based screening and diagnostics, artificial tears, medical management, surgical management, and future directions. Current guidelines, published studies, and the personal experience of internationally recognized dry eye experts are distilled into practical tips that will be of value during daily clinical routine. Highlighted boxes are included to emphasize the most important points or clinical pearls, and tables and flow charts will further assist the eye care practitioner in using the book as a quick reference. The closing chapter presents case examples that build upon the instruction provided earlier in the book by illustrating the optimal approach to diverse scenarios that may be encountered in the clinic.
  • 2014 PsychiatryOnline
    edited by John W. Barnhill.
    Neurodevelopmental disorders -- Schizophrenia spectrum and other psychotic disorders -- Bipolar and related disorders -- Depressive disorders -- Anxiety disorders -- Obsessive-compulsive and related disorders -- Trauma- and stressor-related disorders -- Dissociative disorders -- Somatic symptom and related disorders -- Feeding and eating disorders -- Elimination disorders -- Sleep-wake disorders -- Sexual dysfunctions -- Gender dysphoria -- Disruptive, impulse-control, and conduct disorders -- Substance-related and addictive disorders -- Neurocognitive disorders -- Personality disorders -- Paraphilic disorders.
    Also available: Print – 2014
  • 2014 PsychiatryOnline
    Michael B. First.
    Part I. Differential diagnosis step by step -- Part II. Differential diagnosis by the trees -- Part III. Differential diagnosis by the tables -- Neurodevelopmental disorders -- Schizophrenia spectrum and other psychotic disorders -- Bipolar and related disorders -- Depressive disorders -- Anxiety disorders -- Obsessive-compulsive and related disorders -- Trauma- and Stressor-related disorders -- Dissociative disorders -- Somatic symptom and related disorders -- Feeding and eating disorders -- Sleep-wake disorders -- Sexual dysfunctions -- Gender dysphoria -- Disruptive, impulse-control, and conduct disorders -- Substance-related and addictive disorders -- Neurocognitive disorders -- Personality disorders -- Paraphilic disorders.
    Also available: Print – 2014
  • 1994 PsychiatryOnline
    Also available: Print – 1994
  • v. 1-3, 1994-97
    edited by Thomas A. Widiger ... [et al.].
    Status: Not Checked OutLane Catalog Record
  • 2000 PsychiatryOnline
    Also available: Print – 2000
  • 2013 PsychiatryOnline
    Section 1. DSM-5 basics. Introduction -- Use of the manual -- Cautionary statement for forensic use of DSM-5 -- Section 2. Diagnostic criteria and codes. Neurodevelopmental disorders -- Schizophrenia spectrum and other psychotic disorders -- Bipolar and related disorders -- Depressive disorders -- Anxiety disorders -- Obsessive-compulsive and related disorders -- Dissociative disorders -- Somatic symptom and related disorders -- Feeding and eating disorders -- Elimination disorders -- Sleep-wake disorders -- Sexual dysfunctions -- Gender dysphoria -- Disruptive, impulse-control, and conduct disorders -- Substance-related and addictive disorders -- Neurocognitive disorders -- Personality disorders -- Paraphilic disorders -- Other mental disorders -- Medication-induced movement disorders and other adverse effect of medication -- Other conditions that may be a focus of clinical attention -- Section 3. Emerging measures and models. Assessment measures -- Cultural formulation -- Alternative DSM-5 Model for Personality Disorders -- Conditions for further study -- Appendix. Highlights of changes from DSM-IV to DSM-5 -- Glossary of technical terms -- Alphabetic listing of DSM-5 diagnoses and codes (ICD-9-CM and ICD-10-CM) -- Numerical listing of DSM-5 diagnoses and codes (ICD-9-CM) -- Numerical listing of DSM-5 diagnoses and codes (ICD-10-CM) -- DSM-5 advisors and other contributors.
    Also available: Print – 2013
  • 2002 CRCnetBASE
    edited by Stellos M. Tavantzis.
  • 2007/2008
    Erik George Huntzicker.
    Status: Not Checked OutLane Catalog Record
  • 2005 Karger
    volume editors, R. Stohler, W. Rossler.
    Etiological theories on the relationship of mental disorders and substance use disorders / Moggi, F. -- The genetic basis of substance use and abuse / Jacobson, K.C. -- Paths of genetic and environmental influence: the routes connecting personality disorders with substance use disorders / Cadoret, R.J. ... [et al.] -- Historical and conceptual issues / Jacobs, W.S., Cahill, K.S., Gold, M.S. -- Comorbidity in alcohol use disorders: focus on mood, anxiety and personality / Hintz, T., Mann, K. -- Having attention-deficit/hyperactivity disorder and substance use disorder: a review of the literature / Eich, D., Figner, B. -- Diagnostic issues in dual diagnosis patients / Petitjean, S. -- Neurocognitive impairment: an underdiagnosed comorbid entity in the treatment of substance use disorders / Dorsteler-MacFarland, K.M., Cereghetti, K.H., Wiesbeck, G.A. -- Modified therapeutic communities for co-occurring substance abuse and psychiatric disorders / Leon, G.D.
  • 2015 Springer
    Carlo N. De Cecco, Andrea Laghi, U. Joseph Schoepf, Felix G. Meinel, editors.
    The aim of this book is fourfold: to describe the basic principles of Dual Energy CT (DECT) imaging, to explain how post-processing is utilized, to critically appraise the strengths and weaknesses of the technique in oncologic imaging, and above all, to demonstrate the contribution of DECT in the management of oncologic patients. Information is provided on the practice and interpretation of DECT and its impact on clinical decision making in a variety of oncological settings, including tumors of the head and neck, lung, liver, pancreas, gastrointestinal system, kidney, and musculoskeletal system. DECT is an innovative imaging technique in which the application of two distinct energy settings provides a transition from density-based image to spectral imaging. As detailed in this book, DECT acquisition allows the simultaneous generation of multiple datasets which enable the radiologist to address varied diagnostic problems in oncologic imaging using a multiparametric approach, having clear advantages in tumor detection, lesion characterization and evaluation of treatment response.
  • 2008 Springer
    Peter R. Seidensticker, Lars K. Hofmann, [eds.].
  • 2008 Stanford
    Londa Schiebinger, Andrea Davies Henderson, Shannon K. Gilmartin.
  • 2015 Springer
    Patricia M. Carrascosa, Ricardo C. Cury, Mario J. García, Jonathon A. Leipsic, editors.
    This book focuses on the rapidly developing and promising novel applications of Dual Energy CT (DECT) in cardiovascular medicine. Although developed many years ago, DECT represents the newest significant advancement in the field of computed tomography, the clinical utility of which has recently expanded as many new applications have been developed. In the field of cardiovascular medicine, DECT has been applied for purposes such as the evaluation of myocardial ischemia, myocardial viability and atherosclerotic plaque characterization. As the first book of its kind, Dual-Energy CT in Cardiovascular Imaging contains practical and clinically relevant information on the protocols used that provide precise quantification of coronary artery stenosis using either different monochromatic levels or material decomposition, reduction of beam hardening artifacts in perfusion studies and optimizing endovenous contrast, among others. It is therefore a valuable read for residents, fellows and practicing clinicians in cardiac imaging and cardiology.
  • 2013 Ovid
    Jaeger, Edward A.; Tasman, William S.
    Duane's Clinical ophthalmology -- Duane's Foundations of clinical ophthalmology -- New and Revised Chapters: Duane's Clinical Ophthalmology -- New and Revised Chapters: Duane's Foundations of Clinical Ophthalmology -- 2012 New and Revised Chapters: Duane's Clinical Ophthalmology -- 2012 New and Revised Chapters: Duane's Foundations of Clinical Ophthalmology -- 2013 New and Revised Chapters: Duane's Clinical Ophthalmology -- 2013 New and Revised Chapters: Duane's Foundations of Clinical Ophthalmology.
  • 2013 Ovid
    editors, William Tasman, Edward A. Jaeger.
    Duane's Clinical ophthalmology -- Duane's Foundations of clinical ophthalmology -- New and Revised Chapters: Duane's Clinical Ophthalmology -- New and Revised Chapters: Duane's Foundations of Clinical Ophthalmology -- 2012 New and Revised Chapters: Duane's Clinical Ophthalmology -- 2012 New and Revised Chapters: Duane's Foundations of Clinical Ophthalmology.
  • 2007 Ovid
    editors, William Tasman, Edward A. Jaeger.
    Duane's Clinical ophthalmology -- Duane's Foundations of clinical ophthalmology -- New and revised chapters: Duane's Clinical ophthalmolgy -- New and revised chapters: Duane's Foundations of clinical ophthalmology.
  • 2011 Ovid
    editors, William Tasman, Edward A. Jaeger.
    Duane's Clinical ophthalmology -- Duane's Foundations of clinical ophthalmology -- New and Revised Chapters: Duane's Clinical Ophthalmology -- New and Revised Chapters: Duane's Foundations of Clinical Ophthalmology.
  • 2013 ClinicalKey
    edited by Daniel J Wallace, Bevra Hannahs Hahn ; associate editors, David Isenburg [and others].
    Definition and Classification of Lupus and Lupus-Related Disorders -- The Epidemiology of Lupus -- The Pathogenesis of SLE -- Genetics of Human SLE -- Epigenetics of Lupus -- The Innate Immune System in SLE -- Cytokines and Interferons in Lupus -- The Structure and Derivation of Antibodies and Autoantibodies -- T Cells -- Regulatory Cells in SLE -- Apoptosis, Necrosis, and Autophagy -- Abnormalities in Immune Complex Clearance and Fcγ Receptor Function -- Neural-Immune Interactions: Principles and Relevance to SLE -- Complement and SLE -- Mechanisms of Acute Inflammation and Vascular Injury in SLE -- Mechanisms of Tissue Damage-Free Radicals and Fibrosis -- Animal Models of SLE -- Pathogenetic Mechanisms in Lupus Nephritis -- Immune Tolerance Defects in Lupus -- Autoantibodies -- Autoantigenesis and Antigen-Based Therapy and Vaccination in SLE -- Overview and Clinical Presentation -- Pathomechanisms of Cutaneous Lupus Erythematosus -- Skin Disease in Cutaneous Lupus Erythematosus -- The Musculoskeletal System and Bone Metabolism -- Pathogenesis and Treatment of Atherosclerosis in Lupus -- Cardiopulmonary Disease in SLE -- Pathogenesis of the Nervous System -- Clinical Aspects of the Nervous System -- Psychopathology, Neurodiagnostic Testing, and Imaging -- Ocular, Aural, and Oral Manifestations -- Management of Sjögren Syndrome in Patients with SLE -- Gastrointestinal and Hepatic Manifestations -- Hematologic and Lymphoid Abnormalities in SLE -- Clinical and Epidemiologic Features of Lupus Nephritis -- Pregnancy in Women with SLE -- Neonatal Lupus Erythematosus -- Reproductive and Hormonal Issues in Women with Autoimmune Diseases -- Drug-Induced Lupus: Etiology, Pathogenesis, and Clinical Aspects -- SLE in Childhood and Adolescence -- Mixed Connective Tissue Disease and Undifferentiated Connective Tissue Disease -- Clinical Aspects of the Antiphospholipid Syndrome -- Clinical Application of Serologic Tests, Serum Protein Abnormalities, and Other Clinical Laboratory Tests in SLE -- Differential Diagnosis and Disease Associations -- SLE and Infections -- Clinical Measures, Metrics, and Indices -- Principles of Therapy, Local Measures, and Nonsteroidal Medications -- Systemic Glucocorticoid Therapy in SLE -- Antimalarial Medications -- Immunosuppressive Drug Therapy -- Specialized Treatment Approaches and Niche Therapies for Lupus Subsets -- Adjunctive and Preventive Measures -- Novel Therapies for SLE: Biological Agents Available in Practice Today -- Critical Issues in Drug Development for SLE -- Socioeconomic and Disability Aspects -- Investigational Agents and Future Therapy for SLE -- Mortality in SLE.
  • 2007 Ovid
    editors, Daniel J. Wallace, Bevra Hannahs Hahn.
    Also available: Print – 2007
  • 2015 Springer
    Lisa A. Newman, Jessica M. Bensenhaver, editors.
    This volume reviews the evolution of information regarding the epidemiology of DCIS and its modes of detection, as well as treatment options as a function of both clinical trial data and ongoing investigational therapeutic prospects. Several of the challenging and clinically-relevant scenarios of DCIS that appear in daily practice is discussed, including the difficulties of distinguishing "true" DCIS from borderline patterns of other breast diseases and the therapeutic implications of differentiating these various diagnoses. Particular attention is paid to pathologic evaluation of DCIS, including histologic patterns and the importance of margin evaluation/margin control. The text also explores the data regarding DCIS in medical research in hereditary susceptibility for breast cancer and race/ethnicity-associated disparities in breast cancer. Written by experts in the field, Ductal Carcinoma In Situ and Microinvasive/Borderline Breast Cancer is a comprehensive, state-of-the art review of the field, and serves as a valuable resource for clinicians, surgeons and researchers with an interest in breast cancer.
  • 2016 Cambridge
    edited by John H. Sampson.
    1. Genetics of glioma / Landon J. Hansen, Bill H. Diplas, Joseph Webb, Oren Becher and Hai Yan -- 2. Glioma surgery / Kyle G. Halvorson and Allan H. Friedman -- 3. Radiation therapy for gliomas / John P. Kirkpatrick, Grace Kim and John H. Sampson -- 4. Chemotherapy for gliomas / Annick Desjardins and Henry S. Friedman -- 5. Immunotherapy for gliomas / Peter E. Fecci, Katherine Riccione, Gavin P. Dunn, Elizabeth Reap, Gordana Vlahovic, Kendra Congdon and John H. Sampson -- 6. Neuroradiology of gliomas / Peter G. Kranz -- 7. Neuropathology of gliomas / Roger McLendon and Thomas J. Cummings -- 8. Design and statistical analysis of clinical trials for glioma therapy / James E. Herndon, II -- 9. Health-related quality of life in glioma patients / Katherine B. Peters -- Index.
  • Provenzale, James M.; Nelson, Rendon C.; Vinson, Emily N.
    Status: Not Checked OutLane Catalog Record
  • 2012 ClinicalKey
    Wells I. Mangrum [and others].
    T1 contrast / Phil Hoang ... [et al.] -- T2 contrast / Scott Duncan and Tim Amrhein -- Proton density / Kimball Christianson ... [et al.] -- Gadolinium-based contrast agents / Kimball Christianson, Allen Song, Elmar Merkle -- Preparatory pulses / Phil Hoang ... [et al.] -- Inversion recovery / Phil Hoang ... [et al] -- Chemical shift type 2 artifact / Scott Duncan and Tim Amrhein -- Susceptibility artifact / Wells Mangrum, Elmar Merkle, Allen Song -- Motion, pulsation and other artifacts / Kimball Christianson ... [et al.] -- Flow-related contrast / Scott Duncan and Tim Amrhein -- Time-of-flight imaging / Scott Duncan and Tim Amrhein -- Time-resolved contrast enhanced MRA / Kimball Christianson ... [et al.] -- Phase contrast / Scott Duncan and Tim Amrhein -- Diffusion MRI / Kimball Christianson ... [et al.] -- Perfusion MRI / Wells Mangrum ... [et al.] -- Magnetic resonance spectroscopy / Wells Mangrum, Allen Song, Jeffrey Petrella -- Functional MRI -- Wells Mangrum ... [et al.].
  • Mangrum, Wells I.; Christianson, Kimball L.
    Status: Not Checked OutLane Catalog Record
  • 2016 ClinicalKey
    [edited by] James C. Duke.
    Autonomic nervous system -- Respiratory and pulmonary physiology -- Blood gas and acid-base analysis -- Volume regulation, volume disturbances, and fluid replacement -- Electrolytes -- Transfusion therapy -- Coagulation -- Airway management -- Pulmonary function testing -- Volatile anesthetics -- Opioids -- Intravenous anesthetics and benzodiazepines -- Muscle relaxants and monitoring of relaxant activity -- Local anesthetics -- Inotropes and vasodilator drugs -- Preoperative medication -- Preoperative evaluation -- The anesthesia machine and vaporizers, and anesthesia circuits and ventilators -- Patient positioning -- Mechanical ventilation in critical illness -- Pulse oximetry -- Capnography -- Central venous catheterization and pressure monitoring -- Flow-directed therapy -- Blood pressure disturbances, arterial catheterization, and blood pressure monitoring -- Awareness during anesthesia -- Temperature disturbances -- Postanesthetic care -- Ischemic heart disease and myocardial infarction -- Heart failure -- Valvular heart disease -- Aorto-occlusive diseases -- Intracranial and cerebrovascular disease -- Reactive airway disease -- Aspiration -- Chronic obstructive pulmonary disease -- Acute respiratory distress syndrome (ards) -- Pulmonary hypertension -- Perioperative hepatic dysfunction and liver transplantation -- Renal function and anesthesia -- Increased intracranial pressure and traumatic brain injury -- Malignant hyperthermia and other motor diseases -- Degenerative neurologic diseases and neuropathies -- Alcohol and substance abuse -- Diabetes mellitus -- Nondiabetic endocrine disease -- Obesity and sleep apnea -- Allergic reactions -- Herbal supplements -- Trauma -- The burned patient, laser surgery and operating room fires -- Neonatal anesthesia -- Pediatric anesthesia -- Congenital heart disease -- Fundamentals of obstetric anesthesia -- Obstetric analgesia and anesthesia -- High-risk obstetrics -- Geriatric anesthesia -- Sedation and anesthesia outside the operating room -- Pacemakers and internal cardioverter defibrillators -- Spinal anesthesia -- Epidural analgesia and anesthesia -- Peripheral nerve blocks -- Principles of anesthesia in heart transplantation -- Cardiopulmonary bypass -- Lung isolation techniques -- Somatosensory-evoked potentials and spinal surgery -- Anesthesia for craniotomy -- Minimally invasive surgery -- Electroconvulsive therapy -- Acute pain management -- Chronic pain management.
  • 2008 CRCnetBASE
    James A. Duke ; with Peggy-Ann K. Duke, Judith L. duCellie [sic. duCellier].
    Acknowledgments -- Introduction -- Author -- Bibliographic abbreviations -- Chemical and medical abbreviations -- Hushpuppy -- Format of this book -- Catalog of "faith-based" farmaceuticals -- References -- Common name index -- Scientific name index.
  • 2010 PsychiatryOnline
    edited by Mina K. Dulcan.
    Assessing infants and toddlers -- Assessing the preschool-age child -- Assessing the elementary school-age child -- Assessing adolescents -- Classification of psychiatric disorders -- The process of assessment and diagnosis -- Diagnostic interviews -- Rating scales -- Pediatric evaluation and laboratory testing -- Neurological examination, electroencephalography, and neuroimaging -- Psychological and neuropsychological testing -- Intellectual disability (mental retardation) -- Autism spectrum disorders -- Developmental disorders of learning, communication, and motor skills -- Attention-deficity/hyperactivity disorder -- Oppositional defiant disorder and conduct disorder -- Substance abuse and addictions -- Depression and dysthmyia -- Biopolar disorder -- Generalized anxiety disorder, specific phobia, panic disorder, social phobia, and selective mutism -- Separation anxiety disorder and school refusal -- Posttraumatic stress disorder -- Obsessive-compulsive disorder -- Early-onset schizophrenia -- Obesity -- Anorexia nervosa and bulimia nervosa -- Tic disorders -- Elimination disorders -- Sleep disorders -- Evidence-based practices -- Child abuse and neglect -- HIV and AIDS -- Bereavement and traumatic grief -- Ethnic, cultural, and religious issues -- Youth suicide - Gender identity and sexual orientation -- Aggression and violence -- Genetics: fundamentals relevant to child and adolescent psychiatry -- Psychiatric emergencies -- Family transitions: challenges and resilience -- Psychiatric aspects of chronic physical disorders -- Children of parents with psychiatric and substance abuse disorders -- Legal and ethical issues --; Telepsychiatry -- Principles of psychopharmacology -- Medications used for attention-deficit/hyperactivity disorder -- Antidepressants -- Mood stabilizers -- Antipsychotic medications -- Apha-adrenergics, beta-blockers, benzodiazepines, buspirone, and desmopressin - Medications used for sleep -- Electroconvulsive therapy, transcranial magnetic stimulation, and deep brain stimulation -- Individual psychotherapy -- Parent counseling, psychoeducation, and parent support groups -- Behavioral parent training --- Family therapy - Interpersonal psychotherapy for depressed adolescents -- Cognitive-behavioral treatment for anxiety disorders -- Cognitive-behavioral therapy for depression - Motivational interviewing -- System of care, wraparound services,and home-based services -- Milieu treatment: inpatient, partial hospitalization, and residential programs -- School-based interventions -- Collaborating with primary care -- Juvenile justice.
  • 2014 Springer
    Erika Mendoza, Christopher R. Lattimer, Nick Morrison, editors.
    This book describes in detail the use of duplex ultrasound for exploration of the superficial veins and their pathology. It has a practical orientation, presenting numerous clinical situations and explaining how to identify the different sources of reflux, specially in the groin. The investigation of pathology of the saphenous trunks, perforators, and side branches is described in detail. As duplex ultrasound plays an important role during various venous surgical procedures, its application pre-, intra-, and postoperatively is presented. Furthermore, the sonographic appearances of thrombotic pathology of superficial and deep veins, edema, and other conditions that may be observed while exploring the veins are fully described. The book is based on the authors{u2019} extensive clinical experience and is intended to assist fellow practitioners who want to learn more about the technique. It includes a wealth of informative images with the aim of covering every potential situation.
  • 2012 Springer
    Charles Eaton, Michael Heinrich Seegenschmiedt, Ardeshir Bayat, Giulio Gabbiani, Paul M.N. Werker, Wolfgang Wach, editors.
    Part I. Anatomy, Pathology, and Pathophysiology / Charles Eaton -- Part II. The Myofibroblast / Giulio Gabbiani -- Part III. Genetics and Demographics / Ardeshir Bayat -- Part IV. Collagen and Cell Biology / Charles Eaton -- Part V. Surgical Treatment / Paul M.N. Werker -- Part VI. Needle Release and Hand Therapy / Paul M.N. Werker -- Part VII. Additional and New Treatment Options / M. Heinrich Seegenschmiedt -- Part VIII. Future Perspectives / Charles Eaton.
  • 2010 Springer
    Goetz Benndorf ; foreword by K. Sartor.
    Introduction -- Historical considerations -- Anatomy of the cavernous sinus and related structures -- Classification of cavernous sinus fistulas (CSFs) and dural arteriovenous fistulas (DAVFs) -- Etiology, prevalence and natural history of dural cavernous sinus fistulas (DCSFs) -- Neuro-ophthalmology in dural cavernous sinus fistulas (DCSFs) -- Radiological diagnosis of DCSFs -- Endovascular treatment -- Alternative treatment options -- Hemodynamic aspects of DCSFs -- Summary.
  • 2016 Springer
    Stuart Silverman, Bo Abrahamsen, editors.
    Foreword -- Preface -- Osteoporosis: Pathophysiology & Epidemiology -- Antiresorptives -- Anabolics -- Tools for Assessing Fracture Risk and for Treatment Monitoring -- Treatment Failure -- Epidemiology of Atypical Subtrochanteric and Femoral Shaft Fractures -- Bisphosphonate-Related Atypical Femoral Fractures and Their Radiographic Features -- Factors Contributing to Atypical Femoral Fractures -- Clinical Presentation of Atypical Femur Fractures -- Effects of Antiresorptive Therapy on Bone Microarchitecture -- Management of Atypical Femoral Fractures -- Osteonecrosis of the Jaw: Clinico-Pathologic and Radiologic Features -- Epidemiology of Osteonecrosis of the Jaws from Antiresorptive Treatment -- Management of Osteonecrosis of the Jaw in Patients Receiving Antiresorptive Treatment -- Long-Term Efficacy and Safety of Treatments for Osteoporosis -- Management of Drug Holidays -- Patients Who Do Not Take Their Osteoporosis Medications: Can We Help Them Become Compliant? -- Fractures and Healing on Antiresorptive Therapy -- Antiresorptive Therapy and Mortality and Cancer Incidence -- Other Safety Concerns -- The Impact of Regulatory and Scientific Organizations Recommendations on Clinical Decision Making -- Integrated Clinical View on Long-Term Management of Patients with Osteoporosis -- Conclusions.
  • 2009 Springer
    Matthew J. Colloff.
    "The purpose of Dust Mites is to provide a comprehensive reference work for all readers with an involvement or interest in house dust mite research and management, incorporating ... the topics of systematics and identification, physiology, ecology, allergen biochemistry and molecular biology, epidemiology, mite control and allergen avoidance."--From publisher's notes.
  • 2005 Thieme Book
    Mathias Baehr, Michael Frotscher ; with contributions by Wilhelm Kueker ; founding author, Peter Duus ; translated by Ethan Taub ; 400 illustrations, most in color, by Gerhard Spitzer and Barbara Gay.
    Elements of the nervous system -- Somatosensory system -- Motor system -- Brainstem -- Cerebellum -- Diencephalon and autonomic nervous system -- Limbic system -- Basal ganglia -- Cerebrum -- Coverings of the brain and spinal cord: cerebrospinal fluid and ventricular system -- Blood supply and vascular disorders of the central nervous system.
  • 2012 Thieme Book
    Mathias Baehr, Michael Frotscher.
    Elements of the nervous system -- Somatosensory system -- Motor system -- Brainstem -- Cerebellum -- Diencephalon and autonomic nervous system -- Limbic system -- Basal ganglia -- Cerebrum -- 1Coverings of the brain and spinal cord; cerebrospinal fluid and ventricular system -- Blood supply and vascular disorders of the central nervous system.
  • 2009 Springer
    Thomas P. Naiedich, Henri M. Duvernoy, Bradley N. Delman ... [et. al.] ; with contributions by T. Benner ... [et. al.] ; drawings by Jean-Louis Vannson.
  • 2014 Springer
    Angelo A. Licata, Susan E. Williams.
    Dual-energy X-ray absorptiometry (DXA) is the principal x-ray technology used to diagnose osteoporosis in its early, asymptomatic stages, to assess treatment efficacy, and to guide treatment decisions. It remains the gold standard today. A DXA Primer for the Practicing Clinician: A Case-Based Manual for Understanding and Interpreting Bone Densitometry is based on actual clinical encounters and treatment dilemmas encountered by the authors. The content is derived from years of clinical practice and presentations given by the authors at regional and national conferences. It exemplifies not only the complete body of knowledge provided through these lectures but also the full range of previously undiscussed nuances of DXA interpretation. This practical, easy-to-read text captures many of the common challenges of DXA interpretation that clinicians often encounter. The central focus of the book is the presentation of what is normal and what is problematic when using DXA. It presents real-life case histories, their corresponding DXA images, the problems encountered and their solutions. Unique in approach and presentation, this one-of-a-kind case-based manual will be of immense value to all clinicians and students motivated to optimize their diagnostic skills and assessment of patients with abnormal bone densities
  • Elizabeth T. Hurren.
  • 2014 NAP
    Committee on Approaching Death: Addressing Key End of Life Issues, Institute of Medicine of the National Academies.
    A substantial body of evidence shows that broad improvements to end-of-life care are within reach. In Dying in America, a committee of experts finds that improving the quality and availability of medical and social services for patients and their families could not only enhance quality of life through the end of life, but may also contribute to a more sustainable care system. Dying in America is a study of the current state of health care for persons of all ages with a serious illness or medical condition who are likely approaching death, providing a detailed description of important aspects of the current U.S. health care system as they affect Americans nearing the end of life. It also evaluates strategies to integrate care into a person- and family-centered, team-based framework. According to this report, the current health care system of rendering more intensive services than are necessary and the lack of coordination among programs increases risks to patients and creates avoidable burdens on them and their families. This report makes recommendations to create a system that coordinates caregiving and supports and respects the choices of patients and their families.
  • v. 1-2, 1973-75.
    edited by Avivah Zuckerman and David W. Weiss.
    Status: Not Checked OutLane Catalog Record
  • 2013
    Scott Hsieh.
    The utilization of x-ray computed tomography (CT) has increased dramatically in recent decades. While extremely useful, a major drawback of CT scans is their use of ionizing radiation. Today, one quarter of the radiation dose received by the U.S. population can be attributed to CT scans. We present the use of a dynamic attenuator which is capable of personalizing the radiation usage in the scan. This attenuator is inspired by a stationary-source, inverse geometry CT scanner, which is an architecture with several advantages but which is also very complex. The dynamic attenuator consists of a series of movable wedges which together produce a time-varying, piecewise-linear thickness profile. In simulations, this attenuator reduces dose by 30% in nontargeted scans and 50% in targeted scans without increasing peak noise. On many datasets, this attenuator can also achieve order-of-magnitude dynamic range reductions, which may aid in the adoption of photon-counting detectors, a separate technology which may provide additional dose reductions. We show that most of these dose reduction benefits can be achieved using a real-time control algorithm to position the wedges dynamically during the scan. Additionally, we have developed a framework for optimizing the control of a broad range of dynamic attenuators. A prototype system suggests that the level of artifacts produced by the wedge transitions is within the range of tens of Hounsfield units, although further refinements are expected to reduce artifacts. Based on these positive results, we believe that this dynamic, piecewise-linear attenuator is a practical and effective option for CT.
  • 2009 Springer Protocols
    edited by Fahmeed Hyder.
    Dynamic imaging of brain function / Fahmeed Hyder -- Fractal characterization of complexity in dynamic signals : application to cerebral hemodynamics / Peter Herman, Laszlo Kocsis, and Andras Eke -- Wide-field and two-photon imaging of brain activity with voltage- and calcium-sensitive dyes / Ryota Homma ... [et al.] -- Two-photon imaging of capillary blood flow in olfactory bulb glomeruli / Pascale Tiret ... [et al.] -- Astrocytic calcium signaling : mechanism and implications for functional brain imaging / Xiaohai Wang, Takahiro Takano, and Maiken Nedergaard -- Using the light scattering component of optical intrinsic signals to visualize in vivo functional structures of neural tissues / Uma Maheswari Rajagopalan, Kazushige Tsunoda, and Manabu Tanifuji -- Methods for studying functional interactions among neuronal populations / Nandakumar S. Narayanan and Mark Laubach -- Magnetoencephalography (MEG) / Andreas A. Ioannides -- Functiional neuroimaging of spike-wave seizures / Joshua E. Motelow and Hal Blumenfeld -- Tactile and non-tactile sensory paradigms for fMRI and neurophysiologic studies in rodents / Basavaraju G. Sanganahalli ... [et al.] -- Using fMRI for elucidating dynamic interactions / Yul-Wan Sung and Seiji Ogawa -- Resting-state functional connectivity in animal models : modulations by exsanguination / Bharat B. Biswal and Sridhar S. Kannurpatti -- Dynamic magnetic resonance imaging of cerebral blood flow using arterial spin labeling / Afonso C. Silva and Fernando F. Paiva -- Dynamic MRI of small electrical activity / Allen W. Song, Trong-Kha Truong, Marty Woldorff -- Advanced in vivo heteronuclear MRS approaches for studying brain bioenergetics driven by mitochondria / Xiao-Hong Zhu ... [et al.]
  • 2010
    Misung Han.
    T1-weighted dynamic contrast-enhanced (DCE) breast MRI has shown high sensitivity in detecting tumors, but has suffered from low specificity. Accuracy of tumor detection and characterization is enhanced by high temporal and spatial resolution, high signal-to-noise ratio (SNR), reliable fat suppression, and reduction of flow artifacts. This thesis presents imaging techniques for improving DCE breast MRI in terms of imaging speed and image quality. It first demonstrates that slab-phase modulation of the two breast slabs improves parallel imaging quality in terms of SNR and aliasing artifacts. Second, it presents temporal acceleration scheme by using parallel imaging to achieve high temporal resolution. Thorough patient study results are also included. Third, it shows that fat suppression can be improved by applying independent shimming to each breast through in vivo experiments. Finally, it demonstrates that partial saturation can eliminate flow artifacts efficiently in RF-spoiled gradient-echo sequences. This technique would be helpful to quantification of kinetic parameters from DCE-MRI.
  • 2005 Springer
    A. Jackson, D.L. Buckley, G.J.M. Parker, eds. ; with contributions by M.W. Ah-See ... [et al.] ; foreword by A.L. Baert.
  • 2009 Springer
    Robert L. Bard.
  • 2009 Springer
    Bruce Hannon, Matthias Ruth.
    The why and how of dynamic modeling -- Basic epidemic models -- Insect dynamics -- Malaria and sickle cell anemia -- Encephalitis -- Chagas disease -- Lyme disease -- Chicken pox and shingles -- Toxoplasmosis -- The zebra mussel -- Biological control of pestilence -- Indirect susceptible-infected-resistant models of arboviral encephalitis transmission -- Chaos and pestilence -- Catastrophe and pestilence -- Spatial pestilence dynamics.
  • 2009 Springer
    Vadrevu Sree Hari Rao, Ponnada Raja Sekhara Rao.
    Basic models -- Chemostat versus the lake -- Instability tendencies -- Self-regulation -- Wall growth -- Zones of no activation -- Influence of the control mechanisms -- Parameter estimation using dynamic optimization.
  • 2013 Springer
    V. Sree Hari Rao, Ravi Durvasula, editors.
    This book covers modeling of insect vector-borne infectious diseases, which account for some three million deaths worldwide. The authors describe processes for quantifying the vital parameters of diseases transmitted by mosquitoes, sand flies, fleas and ticks. Despite great advances in public health worldwide, insect vector-borne infectious diseases remain a leading cause of morbidity and mortality. Diseases that are transmitted by arthropods such as mosquitoes, sand flies, fleas, and ticks affect hundreds of millions of people and account for nearly three million deaths all over the world. In the past there was very little hope of controlling the epidemics caused by these diseases, but modern advancements in science and technology are providing a variety of ways in which these diseases can be handled. Clearly, the process of transmission of an infectious disease is a nonlinear dynamic process which can be understood only by appropriately quantifying the vital parameters that govern these dynamics --c Source other than Library of Congress.
  • 2013 Springer
    V. Sree Hari Rao, Ravi Durvasula, editors.
    This book covers modeling of insect vector-borne infectious diseases, which account for some three million deaths worldwide. The authors describe processes for quantifying the vital parameters of diseases transmitted by mosquitoes, sand flies, fleas and ticks. Despite great advances in public health worldwide, insect vector-borne infectious diseases remain a leading cause of morbidity and mortality. Diseases that are transmitted by arthropods such as mosquitoes, sand flies, fleas, and ticks affect hundreds of millions of people and account for nearly three million deaths all over the world. In the past there was very little hope of controlling the epidemics caused by these diseases, but modern advancements in science and technology are providing a variety of ways in which these diseases can be handled. Clearly, the process of transmission of an infectious disease is a nonlinear dynamic process which can be understood only by appropriately quantifying the vital parameters that govern these dynamics.
  • 2012 CRCnetBASE
    Hans van Houwelingen, Hein Putter.
    "In the last twenty years, dynamic prediction models have been extensively used to monitor patient prognosis in survival analysis. Written by one of the pioneers in the area, this book synthesizes these developments in a unified framework. It covers a range of models, including prognostic and dynamic prediction of survival using genomic data and time-dependent information. The text includes numerous examples using real data that is taken from the authors collaborative research. R programs are provided for implementing the methods"--Provided by publisher.
  • 2006 Thieme eNeurosurgery
    [edited by] Daniel H. Kim, Frank P. Cammisa, Jr., Richard G. Fessler.
    Also available: Print – 2006
  • 2013 Springer
    Péter Halász, Róbert Bódizs.
    Dynamic Structure of NREM Sleep is a concise guide to Cyclic Alternating Pattern (CAP) phenomenology and slow wave homeostasis. It presents an original approach to a specialized aspect of sleep neuroscience in a concise and easy-to-read format. The authors are specialists in the field of sleep neuroscience and lend a new perspective to the benefits of slow wave activity during sleep. The main feature of this discussion is that slow wave activity increases as a function of previous wakefulness and it gradually decreases in the course of sleep. Alongside developing this idea, this book covers the entire range of sleep issues from basic structure to function in comprehensive detail. Dynamic Structure of NREM Sleep is valuable reading for neurologists, sleep neuroscientists and those with an interest in the field.
  • 2006 CRCnetBASE
    edited by Josef T. Kittler, Stephen J. Moss.
    Methods for uncovering the mechanisms of AMPA receptor trafficking / Sophie Restituito and Edward B. Ziff -- Long-term plasticity at inhibitory synapses: a phenomenon that has been overlooked / Jean-Luc Gaiarsa and Yehezkel Ben-Ari -- New tricks for an old dog: proteomics of the PSD / Bryen A. Jordan ... [et al.] -- Phosphorylation site-specific antibodies as research tools in studies of native GABA[subscript A] receptors / Jasmina Jovanovic -- Protein palmitoylation by DHHC protein family / Yuko Fukata, David S. Bredt, Masaki Fukata -- RNAi and applications in neurobiology / Tija C. Jacob -- Transfecting and transducing neurons with synthetic nucleic acids and biologically active macromolecules / Josef T. Kittler, Jonathan G. Hanley, John T.R. Isaac -- Acute in vivo expression of recombinant proteins in rat brain using Sindbis virus / Hélène Marie & Robert C. Malenka -- Lentivirus-based genetic manipulations in neurons in vivo / Pavel Osten, Tanjew Dittgen, and Pawel Licznerski -- AMPA receptor phosphorylation in synaptic plasticity : insights from knockin mice / Hey-Kyoung Lee -- Genomic and post-genomic tools for studying synapse biology / Josef T. Kittler and Peter L. Oliver. Studying the localization, surface stability and endocytosis of neurotransmitter receptors by antibody labelling and biotinylation approaches / I. Lorena Arancibia-Cárcamo ... [et al.] -- Visualisation of AMPAR trafficking and surface expression / Pavel V. Perestenko and Jeremy M. Henley -- Neurotransmitter dynamics / Sabine Lévi and Antoine Triller -- Receptor dynamics at the cell surface studied using functional tagging / Philip Thomas and Trevor G. Smart --
    Also available: Print – 2006
  • 2009 Springer
    Alain Destexhe, Thierry Bal, editors.
  • 2006/2007
    Marlene Rochelle Cohen.
    Status: Not Checked OutLane Catalog Record
  • 2012
    Mark Akira Tsuchida.
    In actin-based crawling motility, cells continuously build, reorganize, and disassemble an actin network in a process driven jointly by biochemical reactions and mechanical work. Herein, we use isolated actin cytoskeletons from fish epithelial keratocytes to study two aspects of this highly coordinated process. For the continuous actin network of a motile cell to drive translocation, net assembly of the actin network at the leading edge (which drives protrusion) must be balanced by net disassembly at the trailing edge. Although proteins such as ADF/cofilin and gelsolin are known to locally depolymerize actin filaments, it is not clear how such activity could be coordinated with assembly over the distance scale of the whole cell. Here we present experiments showing that activation of nonmuscle myosin II embedded in isolated cytoskeletons results in partial disassembly of the actin network. Taken together with prior work on the effect of myosin II inhibition in live cells, these results establish that myosin II contributes to actin network disassembly in the rear of motile cells, and suggest that gradual binding of myosin to a maturing actin network could serve as a mechanism to coordinate actin network assembly and disassembly over long distances. A thorough understanding of how forces produced by actin and myosin contribute to whole-cell movement will require detailed knowledge of the material properties of the cytoskeletal network at the relevant spatial and temporal scales. Measurements of mechanical properties have largely been limited to microscopic strains, whole-cell bulk measurements, or reconstituted gels that do not fully capture the cellular cytoskeletal organization. We have therefore sought to characterize the deformation of actin networks derived from motile cells under large applied strains. Strain could be applied to the lamellipodial actin network by displacing the cell body using a glass microneedle. The network behaves as a coherent material sheet that is mechanically well-coupled to the cell body and stretches to approximately 400% of its original dimensions. At smaller strains and time scales ranging from a fraction of a second to tens of seconds, the network behaves almost exclusively elastically, suggesting that the cytoskeletal network is capable of integrating and transmitting forces over large distances within the cell.
  • 2006 ScienceDirect
    edited by Markus J. Seibel, Simon P. Robins, John P. Bilezikian.
    Structure, biosynthesis and gene regulation of collagens in cartilage and bone / Klaus von der Mark -- Fibrillogenesis and maturation of collagens / Simon P. Robins -- Vitamin K dependent proteins of bone and cartilage / Caren M. Gundberg and Satoru K. Nishimoto -- Noncollagenous proteins: glycoproteins and related proteins / Dick Heinegård, Pilar Lorenzo, and Tore Saxne -- Proteoglycans and glycosaminoglycans / Tim Hardingham -- Growth factors / Philippa Hulley, Graham Russell, and Peter Croucher -- Prostaglandins and proinflammatory cytokines / Lawrence G. Raisz and Joseph A. Lorenzo -- Integrins and other adhesion molecules / M.H. Helfrich and M.A. Horton -- Alkaline phosphatases / José Luis Millán -- Acid phosphatases / Helena Kaija ... [et al.] -- Matrix proteinases / Ian M. Clark and Gillian Murphy -- Mineralization, structure and function of bone / Adele L. Boskey -- Bone structure and strength / Ego Seeman -- The cells of bone / Jane B. Lian and Gary S. Stein -- Signaling in bone / T. John Martin and Natalie A. Sims -- Parathyroid hormone: structure, function and dynamic actions / Lorraine A. Fitzpatrick and John P. Bilezikian -- Interaction of parathyroid hormone-related peptide with the skeleton / David Goltzman -- The vitamin D hormone and its nuclear receptor: mechanisms involved in bone biology / Geert Carmeliet ... [et al.] -- Sex steroid effects on bone metabolism / David G. Monroe, Thomas C. Spelsberg, and S. Khosla -- Physiology of calcium and phosphate homeostasis / René Rizzoli and Jean-Philippe Bonjour -- The central control of bone remodelling / Paul A. Baldock ... [et al.] -- New concepts in bone remodeling / David W. Dempster and Hua Zhou -- Products of bone collagen metabolism / Juha Risteli and Leila Risteli -- Supramolecular structure of cartilage matrix / Peter Bruckner -- Products of cartilage metabolism / Daniel-Henri Manicourt, Jean-Pierre Devogelaer, and Eugene J.-M.A. Thonar -- Fluid dynamics of the joint space and trafficking of matrix products / Peter A. Simkin -- Transgenic models of bone disease / Barbara E. Kream and John R. Harrison -- The role of genetic variation in osteoporosis / André G. Uitterlinden ... [et al.] -- Measurement of calcium, phosphate and magnesium / Heinrich Schmidt-Gayk -- Measurement of parathyroid hormone / Harald Jüppner and Ghada El-Hajj Fuleihan -- New horizons for assessment of vitamin D status in man / Gary L. Lensmeyer, Neil Binkley, and Marc K. Drezner -- Measurement of biochemical markers of bone formation / Kim E. Naylor and Richard Eastell -- Measurement of biochemical markers of bone resorption / Marius E. Kraenzlin and Markus J. Seibel -- Variability in the measurement of biochemical markers of bone turnover / Tuan V. Nguyen, Christian Meier, and Markus J. Seibel -- Validation of biochemical markers of bone turnover / Kim Brixen and Erik Fink Eriksen -- Genetic markers of joint disease / Michel Neidhart, Renate E. Gay, and Steffen Gay -- Laboratory assessment of postmenopausal osteoporosis / Patrick Garnero and Pierre D. Delmas -- Monitoring anabolic treatment / John P. Bilezikian and Mishaela R. Rubin -- Monitoring of antiresorptive therapy / Christian Meier, Tuan V. Ngyen, and Markus J. Seibel -- Age-related osteoporosis and skeletal markers of bone turnover / Clifford J. Rosen -- Steroid-induced osteoporosis / Ian R. Reid -- Transplantation osteoporosis: biochemical correlates of pathogenesis and treatment / Carolina A. Moreira Kulak and Elizabeth Shane -- Secondary osteoporosis / Jean E. Mulder, Carolina A. Moreira Kulak, and Elizabeth Shane -- Osteomalacia and rickets / Marc K. Drezner -- Assessment of bone and joint diseases: renal osteodystrophy / Esther A. González, Ziyad Al Aly, and Kevin J. Martin -- Primary hyperparathyroidism / Shonni J. Silverberg, and John P. Bilezikian -- Paget's disease of bone / Andreas Grauer, Ethel Siris, and Stuart Ralston -- Metastatic bone disease / Jean-Jacques Body -- Rare bone diseases / Michael P. Whyte -- Osteogenesis imperfecta / Francis H. Glorieux and Frank Rauch -- Rheumatoid arthritis and other inflammatory joint pathologies / Steven R. Goldring and Mary B. Goldring -- Osteoarthritis and degenerative spine pathologies / Kristina Åkesson.
  • 2007 NCBI Bookshelf
    Steven A. Frank.
    Age of cancer incidence -- Multistage progression -- History of theories -- Progression dynamics -- Theory I -- Theory II -- Genetics of progression -- Carcinogens -- Aging -- Inheritance -- Stem cells : tissue renewal -- Stem cells : population genetics -- Cell lineage history.
  • 2012
    Katherine Muterspaugh Steele.
    This dissertation presents the first three-dimensional musculoskeletal simulations of individuals with cerebral palsy and has contributed to our understanding of how muscle contributions, joint loads, and the effects of muscle weakness change in individuals with cerebral palsy and crouch gait. The simulations created for these analyses have been made freely-available for researchers and clinicians to download, use, and evaluate at http://www.simtk.org/home/crouchgait/. This work has provided insight into the underlying dynamics of crouch gait and created pathways to improve treatment. The first objective of this dissertation was to examine how individual muscles contribute to motion during crouch gait. We evaluated how muscles contribute to joint and mass center accelerations to support and propel the body during crouch gait and how these contributions change with crouch severity. The results of these analyses indicated that crouch gait uses similar muscles to support and propel the body as unimpaired gait; however, larger and more sustained muscle activity is required during crouch gait, which contributes to the inefficiencies of this gait pattern. The second objective of this dissertation was to examine how the compressive tibiofemoral force changes in individuals with cerebral palsy and crouch gait. Knee pain is common among individuals with crouch gait and the results of this study demonstrated that tibiofemoral load increases quadratically with crouch severity. Individuals who walk in a severe crouch gait experience three-times the tibiofemoral load than during unimpaired gait. The elevated tibiofemoral forces during crouch gait could contribute to cartilage degeneration and knee pain. The final objective of this dissertation was to examine how muscle weakness may contribute to crouch gait. We used musculoskeletal simulations to determine how much muscle groups can be weakened and still reproduce mild and moderate crouch gait. The results of this analysis demonstrated that crouch gait requires greater quadriceps strength but less hip abductor and ankle plantarflexor strength than unimpaired gait; suggesting that these latter muscles may be better targets for strength training programs. We also performed a meta-analysis of individuals with crouch gait who had participated in strength training programs. This analysis demonstrated that outcomes after strength training are inconsistent, even among individuals with cerebral palsy and crouch gait. Hamstring spasticity was associated with poor outcomes after strength training and may be a contraindication for strength training. The long term goal of the work presented in this dissertation is to improve quality of life for individuals with cerebral palsy. The freedom to walk, explore, and interact with the world is a skill that many of us take for granted every day. Through the combination of musculoskeletal modeling and simulation, experimental studies, and clinical outcomes we can help individuals with gait pathologies achieve this freedom throughout their life.
  • 2002 NAP
    Gooloo S. Wunderlich, Dorothy P. Rice, and Nicole L. Amado, editors ; Committee to Review the Social Security Administration's Disability Review Process Research, Division of Health Care Services, Institute of Medicine and Committee on National Statistics, Division on Behavioral and Social Sciences and Education, National Research Council.
  • 2006
    Wolfgang Schumann.
    Status: Not Checked OutLane Catalog Record
  • 2012 CRCnetBASE
    Abdelhamid Ajbar, Khalid Alhumaizi.
    1. Introduction to stability of bioreactors -- 2. Introduction to bioreactors models -- 3. Introduction to stability and bifurcation theory -- 4. The basic model of ideal chemostat -- 5. The chemostat with wall attachment -- 6. Pure and simple microbial competition -- 7. Stability of continuous recombinant DNA cultures -- 8. Biodegradation of mixed substrates -- 9. Predator-prey interactions -- 10. Ratio-dependent models -- 11. Models with product formation -- 12. Models with product formation : type II models -- 13. Models with product formation : type III models -- 14. Operability of nonideal bioreactors -- 15. Operability of prefermentation of cheese culture -- 16. Biodegradation of wastewater -- 17. Dynamics of activated sludge reactors -- 18. Complex dynamics in forced bioreactors.
  • 2009 Springer
    Kiyotaka Toshimori.
    In humans, male infertility is caused by a number of factors such as the external environment, nutrient changes, genotoxins, and mutagens. This book discusses the events that occur in the normal sperm head and govern the structure-function relationship from the time of spermatogenesis to that of fertilization or egg activation.
  • 2009 Springer
    Meribeth Bunch Dayme.
  • 2001 Springer
    Uwe J. Ilg, Guillaume S. Masson, editors.
  • 2012 ScienceDirect
    Stephen M. King.
    Research on dyneins has a direct impact on human diseases, such as viruses and cancer. With an accompanying website showing over one hundred streaming videos of cell dynamic behavior for best comprehension of material, Dynein: Structure, Biology and Disease is the only reference covering the structure, biology and application of dynein research to human disease. From bench to bedside, Dynein: Structure, Biology and Disease offers research on fundamental cellular processes to researchers and clinicians across developmental biology, cell biology, molecular biology, biophysics, biomedicine, genetics and medicine. . Broad-based up-to-date resource for the dynein class of molecular motors . Chapters written by world experts in their topics . Numerous well-illustrated figures and tables included to complement the text, imparting comprehensive information on dynein composition, interactions, and other fundamental features.
  • 2015 Springer
    Abhimanyu Garg.
    Dyslipidemias: Pathophysiology, Evaluation and Management provides a wealth of general and detailed guidelines for the clinical evaluation and management of lipid disorders in adults and children. Covering the full range of common through rare lipid disorders, this timely resource offers targeted, practical information for all clinicians who care for patients with dyslipidemias, including general internists, pediatric and adult endocrinologists, pediatricians, lipidologists, cardiologists, internists, and geneticists. For the last twenty years, there has been a growing recognition worldwide of the importance of managing dyslipidemia for the primary and secondary prevention of atherosclerotic vascular disease, especially coronary heart disease. This has been mainly due to the publication of the guidelines of National Cholesterol Education Programs Adult Treatment Panel and Pediatric Panel from the United States. These guidelines have stimulated generation of similar recommendations from all over the world, particularly Europe, Canada, Australia and Asia. Developed by a renowned group of leading international experts, the book offers state-of-the-art chapters that are peer-reviewed and represent a comprehensive assessment of the field. A major addition to the literature, Dyslipidemias: Pathophysiology, Evaluation and Management is a gold-standard level reference for all clinicians who are challenged to provide the best care and new opportunities for patients with dyslipidemias.
  • 2014 Springer
    edited by Adrian Covic, Mehmet Kanbay, Edgar V. Lerma.
  • 2011 Springer
    Marko Duvnjak.
    The Definition of Dyspepsia -- Subgroups of Dyspepsia -- Epidemiology -- Structural Causes of Dyspepsia -- Functional (Nonulcer) Dyspepsia -- How to Diagnose Dyspepsia -- Differential Diagnosis: Overlap Between Gastroesophageal Reflux Disease and Irritable Bowel Syndrome -- Management of Uninvestigated Dyspepsia -- Management of Helicobacter pylori Infection -- Management of Peptic Ulcer Disease -- Therapeutic Approach in Functional (Nonulcer) Dyspepsia -- Prognosis -- Quality of Life Issues -- Economic Analyses of Present Management Strategies and Nonprescription Therapy in Treatment of Dyspepsia -- Dyspepsia in Children: Epidemiology, Clinical Presentation, and Causes -- Diagnostic Tests and Treatment of Dyspepsia in Children -- Dyspepsia in the Elderly -- Diabetes Mellitus and Dyspepsia.
  • 2012 Springer
    Olle Ekberg, editor ; foreword by Maximilian F. Reiser.
    Part I. Anatomy and Physiology -- Anatomy and Physiology / Olle Ekberg and Göran Nylander -- Saliva and the Control of Its Secretion / Jörgen Ekström, Nina Khosravani, Massimo Castagnola and Irene Messana -- Feeding and Respiration / Olle Ekberg, Anna I. Hårdemark Cedborg, Katarina Bodén, Hanne Witt Hedström and Richard Kuylenstierna, et al. -- Oral and Pharyngeal Function and Dysfunction / Olle Ekberg -- Part II. Evaluation of Symptoms -- Evaluation of Symptoms / Doris-Maria Denk-Linnert -- Neurology of Swallowing and Dysphagia / Mario Prosiegel -- Gastroesophageal Reflux Disease, Globus, and Dysphagia / Jacqui Allen and Peter C. Belafsky -- Pediatric Aspect of Dysphagia / Pascale Fichaux Bourin, Michèle Puech and Virginie Woisard -- Dysphagia in Systemic Disease / Thomas Mandl and Olle Ekberg -- The Geriatric Pharynx and Esophagus / Olle Ekberg -- Voice and Dysphagia / Daniele Farneti -- Psychiatric Aspects of Dysphagia / Margareta Bülow -- Part III. Imaging and other Examination Techniques -- The Clinical and Radiological Approach to Dysphagia / Peter Pokieser and Martina Scharitzer -- Imaging Techniques and Some Principles of Interpretation (Including Radiation Physics) / Olle Ekberg -- Pharyngeal Morphology / Stephen E. Rubesin -- Morphology of the Esophagus / Marc S. Levine and Arastoo Vossough -- The Pediatric Esophagus / Jane E. Benson -- Pharyngeal Manometry / Rolf Olsson -- Esophageal Manometry and Gastroesophageal Reflux Monitoring / Karin Aksglæde, Per Thommesen and Peter Funch-Jensen -- Impedance Planimetry / Johannes Lenglinger -- Radiologic Evaluation of Esophageal Function / Wolfgang Schima, Edith Eisenhuber and Christiane Kulinna-Cosentini -- Neuroimaging in Patients with Dysphagia / Kasim Abul-Kasim -- Cross-Sectional Imaging of the Oesophagus Using CT and PET/Techniques / Ahmed Ba-Ssalamah, Barbara J. Fueger and Wolfgang Schima -- Endoscopy of the Pharynx and Esophagus / Doris-Maria Denk-Linnert and Rainer Schöfl -- Part IV. Treatment -- The Therapeutic Swallowing Study / Margareta Bülow and Bonnie Martin-Harris -- Surgical Aspects of Pharyngeal Dysfunction, Dysphagia, and Aspiration / Hans F. Mahieu and Martijn P. Kos -- The Post-Operative Pharynx and Larynx / Anita Wuttge-Hannig and Christian Hannig -- Dysphagia Evaluation and Treatment After Head and Neck Surgery and/or Chemo-radiotherapy for Head and Neck Malignancies / Antonio Schindler, Francesco Mozzanica and Filippo Barbiera -- Behavioural Treatment of Oropharyngeal Dysphagia: Bolus Modification and Management, Sensory and Motor Behavioural Techniques, Postural Adjustments, and Swallow Manoeuvres / Renée Speyer -- Rheological Aspects of Swallowing and Dysphagia / Edmundo Brito-de la Fuente, Olle Ekberg and Críspulo Gallegos -- The Dietitian's Role in Diagnosis and Treatment of Dysphagia / S. Burton, A. Laverty and M. Macleod -- Direct and Indirect Therapy: Neurostimulation for the Treatment of Dysphagia After Stroke / Satish Mistry, Emilia Michou, Dipesh H. Vasant and Shaheen Hamdy -- Intervention on the Esophagus / Jason D. Conway, David J. Ott and Michael Y. Chen -- The Importance of Enteral Nutrition / Christina Stene and Bengt Jeppsson -- Part V. Complications -- Complications of Oropharyngeal Dysphagia: Malnutrition and Aspiration Pneumonia / Silvia Carrión, Eric Verin, Pere Clavé and Alessandro Laviano -- Dehydration in Dysphagia / Zeno Stanga, Samuel Hannes Baldinger and Pere Clavé.
  • 2015 Springer
    Petr Kanovsky, Kailash P. Bhatia, Raymond L. Rosales, editors.
    Part I. Pathophysiology and nosology of dystonia -- Dystonia: History of the term and syndrome -- Physiology of dystonia -- Genetics of dystonia -- Nosology and classification of dystonia -- Secondary dystonias -- Dystonia -- parkinsonism syndromes -- Dystonia in multiple system atrophy and progressive supranuclear palsy -- Psychogenic dystonia -- Part II. Treatment of dystonia -- Pharmacological treatment of dystonia -- Botulinum toxin treatment of dystonia -- Long-term BoNT treatment of dystonia -- Brain plasticity in dystonia -- Surgical treatment of dystonia -- Indications of deep brain stimulation in dystonia -- Pitfalls of deep brain stimulation in dystonia -- Neurorehabilitation in dystonia -- Dystonia in Art: The Impact of Psychiatric and Neurological Disease on the Work of the Sculptor F.X. Messerschmidt.

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A repository of medical knowledge from internal medicine, cardiology, genetics, pharmacy, diagnosis and management, basic sciences, patient care, and more.

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MicroMedex: Premier pharmaceutical information source containing multiple databases and drug reference tools. Of particular value is DRUGDEX Evaluations, one of the most comprehensive drug sources available.DynaMed is a clinical information resource used by physicians to answer clinical questions quickly and easily at the point of care. Topics are updated daily as new evidence becomes available.Scopus is the largest abstract and citation database of peer-reviewed literature: scientific journals, books and conference proceedings.A drug information resource containing: American Hospital Formulary System (AHFS), drug formulary for Lucile Packard Children's Hospital (LPCH) and Stanford Hospital & Clinics (SHC), Lexi-Drugs (adverse reactions, dosage and administration, mechanism of action, storage, use, and administration information), Lexi-Calc, Lexi-ID, Lexi-I.V. Compatibility (King Guide), Lexi-Interact, and Lexi-PALS.Cumulative Index to Nursing and Allied Health Literature (CINAHL) contains coverage of nursing and allied health literature.A knowledge database that provides access to topic reviews based on over 6000 clinically relevant articles. The evidence-based content, updated regularly, provides the latest practice guidelines in 59 medical specialtiesProvides critical assessments of systematic reviews compiled from a variety of medical journals.Selects from the biomedical literature original studies and systematic reviews that are immediately clinically relevant and then summarizes these articles in an enhanced abstract with expert commentary.

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