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  • 2009 Springer
    J.-P. Lepoittevin ; C.J. Le Coz ; avec la contribution de Peter J. Frosch.
  • 2013 Springer Protocols
    edited by Ludwig Eichinger, Francisco Rivero.
    Amoebozoa / Christina Schilde and Pauline Schaap -- Model organism Dictyostelium discoideum / Salvatore Bozzaro -- Comparative genomics of the dictyostelids / William F. Loomis -- One stop shop for everything Dictyostelium : dictyBase and the dicty stock center in 2012 / Petra Fey [and others] -- Fluorescent reporters and methods to analyze fluorescent signals / Annette Müller-Taubenberger and Hellen C. Ishikawa-Ankerhold -- Collection and cultivation of dictyostelids from the wild / Tracy E. Douglas [and others] -- Identification and verification of microRNAs by high-throughput sequencing / Jimmie Hällman [and others] -- Transcriptional profiling of Dictyostelium with RNA sequencing / Edward Roshan Miranda [and others] -- Analysis of chromatin organization by deep sequencing technologies / James L. Platt [and others] -- Pharmacogenetics of resistance to cisplatin and other anticancer drugs and the role of sphingolipid metabolism / Stephen Alexander, William S. Swatson, and Hannah Alexander -- N-glycomic and n-glycoproteomic studies in the social amoebae / Christa L. Feasley -- Measuring cheating, fitness, and segregation in Dictyostelium discoideum / Neil J. Buttery [and others] -- Application of the Cre-loxP system for generating multiple knock-out and knock-in targeted loci / Jan Faix [and others] -- Extrachromosomal inducible expression / Douwe M. Veltman and Peter J.M. Van Haastert -- Isolation of Dictyostelium nuclei for light and electron microscopy / Petros Batsios [and others] -- Investigation of DNA repair pathway activity / Anne-Marie C. Couto, Nicholas D. Lakin, and Catherine J. Pears -- Transcript localization in Dictyostelium discoideum cells by RNA FISH / Patrick Hofmann, Janis Kruse, and Christian Hammann -- Analysis of mitochondrial gene expression / Jessica E. Accari [and others] -- Mitochondrial respiratory complex function and the phenotypic consequences of dysfunction / Sarah J. Annesley [and others] -- Micropipette aspiration for studying cellular mechanosensory responses and mechanics / Yee-Seir Kee and Douglas N. Robinson -- Quantitative analysis of phagocytosis and phagosome maturation / Natascha Sattler, Roger Monroy, and Thierry Soldati -- Setting up and monitoring an infection of Dictyostelium discoideum with mycobacteria / Sonia Arafah [and others] -- Isolation of pathogen-containing vacuoles / Olga Shevchuk and Michael Steinert -- Immunomagnetic purification of fluorescent legionella-containing vacuoles / Ivo Finsel, Christine Hoffmann, and Hubert Hilbi -- Secretory lysosomes in Dictyostelium : visualization, characterization, and dynamics / Wanessa C. Lima and Pierre Cosson -- Monitoring autophagy in Dictyostelium / Ana Mesquita [and others].
  • 2006 Springer Protocols
    edited by Ludwig Eichinger, Francisco Rivero.
  • v. 1-, 2010- Springer
  • 2015 Wiley
    Tahira Farooqui and Akhlaq A. Farooqui, editors.
    "Diet and Exercise in Cognitive Function and Neurological Diseases looks at the role and impact that nutrition and activity have on cognitive function and neurological health. The book is divided into the two sections. The first focuses on diet and its impact on neurobiological processes. Chapters focus on the impacts of specific diets, such as the Mediterranean diet, ketogenic and vegan diets, as well as the role specific nutrients, fats, fatty acids, and caloric intake have on neurological health and cognitive function. The second part of the book focuses on exercise, and its role in maintaining cognitive function, reducing neuroinflammatory responses, regulating adult neurogenesis, and healthy brain aging. Other chapters in this section look at the impacts of disease in the management of specific neurological disorders such multiple sclerosis and Parkinson's disease. Collectively, the chapters in Diet and Exercise in Cognitive Function and Neurological Diseases come together to form a timely reference on the neurobiological interplay between diet and exercise on long-term brain health and cognitive function"--Provided by publisher.
  • 2015 Springer
    Rajkumar Rajendram, Victor R. Preedy, Vinood B. Patel, editors.
  • 2011 CRCnetBASE
    edited by Victor R. Preedy.
  • 2012 CRCnetBASE
    edited by Robin B. Kanarek and Harris R. Lieberman.
    Mental energy and fatigue : science and the consumer / Harris R. Lieberman -- Hydration and brain function / Kristen E. D'Anci -- Diet as an analgesic modality / Alexis M. Codrington, Yoram Shir, and John Pereira -- Breakfast and adult and children behaviors / Andrew P. Smith -- Diet, physical activity, and substrate oxidation : implications for appetite control, weight loss, and body composition / Mark Hopkins, Neil A. King, and John E. Blundell -- The reward deficiency hypothesis : implications for obesity and other eating disorders / Brenda M. Geiger, Erin N. Umberg, and Emmanuel N. Pothos -- Potential consequences of obesity on cognitive behavior / Nicole A. Jurdak and Robin B. Kanarek -- Dietary supplements for weight loss / Igho Onakpoya and Edzard Ernst -- Sweet taste preferences and cravings in gestational diabetes mellitus (GDM) : implications for diet and medical management / Beverly J. Tepper ... [et al.] -- Homocysteine, B vitamins, and cognitive function / Joshua W. Miller -- Creatine, brain functioning, and behavior / Patricia J. Allen, Kristen E. D'Anci, and Robin B. Kanarek -- Theanine, mood, and behavior / Jessica E. Smith and Peter J. Rogers -- Caffeine : practical implications / Andrew P. Smith -- Caffeine effects on aggression and risky decision making / Caroline R. Mahoney, Tad T. Brunyé, and Grace E. Giles.
  • 2005 Karger
    volume editor, Ibrahim Elmadfa.
    Fat intake, diet variety, and health promotion / Elmadfa, I., Freisling, H. -- Mixed diet in Europe : a historical overview / Spiekermann, U. -- Influences on food choice and dietary behavior / Shepherd, R. -- Age and gender dependent profile of food choice / Westenhoefer, J. -- Diversification in indigenous and ethnic food culture / Wahlqvist, M.L. -- Organic foods : do they have a role? / Kpke, U. -- Impact of 'functional food' / Guesry, P.R. -- The role of fortified foods : situation in Austria / Wagner, K.-H. ... [et al.] -- Attitudes of Austrian adults to the consumption of fruits and vegetables / Rust, P., Elmadfa, I. -- Health effects of phytoestrogens / Branca, F., Lorenzetti, S. -- Exploitation of convenience food in view of a diet diversification for better nutrition / Berghofer, E. -- Adulteration of foodstuffs : from misleading to poisoning / Bnti, D. -- Macro- and micronutrients in a traditional Greek menu / Trichopoulou, A., Vasilopoulou, E., Georga, K. -- Vegetarian diets : what are the advantages? / Leitzmann, C. -- Food safety and consumers' attitude in a new EU member state : a case study of Hungary / Bnti, D., Lakner, Z. -- Making the healthy choice an easy choice : from nutrition science to consumer action / Verschuren, P.M. -- Diversification and food choice, the consumer's view / Kettlitz, B.
  • 2014 CRCnetBASE
    edited by C. Murray Ardies.
    "The idea of producing a book on the prevention of chronic diseases through exercise and diet was intriguing for me when I was first approached with the idea. I had been teaching nutrition, exercise, and health science courses with a focus on cellular aspects of prevention for many years and had to develop all of my own materials because very few books were available. And of those that were, they had a decided clinical approach with very little discussion about the actual biochemistry or molecular mechanisms involved in prevention. When I broached the concept with several potential coauthors, the prevailing opinion was that books that covered biochemical and molecular aspects of disease etiology also were in very short supply. Thus this book was born: an attempt to collate the latest cellular- and molecularbased research on the etiology of chronic diseases with how these mechanisms of cause are modified by various aspects of diet and exercise. Essentially, we have tried to produce a text that translates molecular-based data on etiology and prevention into a clinical prescription for the prevention of chronic disease. The focus on diabetes, atherosclerosis, osteoporosis, cancer, and degenerative neurological disease is because they are the major causes of morbidity and mortality by chronic disease and also because there is sufficient molecular evidence for a strong dietary and activity (or rather, an insufficiency of both) component to their etiology. The inclusion of a separate chapter on "Inflammation" became necessary when it was clear that inflammatory signaling is a fundamental component of each of these diseases and that reducing inflammation is key to reducing risk for all of these diseases. At the time we started, obesity had not yet been declared a diseas"-- Provided by publisher.
  • 2012 CRCnetBASE
    edited by John J.B. Anderson, Sanford C. Garner, Philip J. Klemmer.
    "Presenting recent advancements in research findings and the resulting new schools of thought on the physiology of human bone, this comprehensive reference examines information on dietary pattern and specific nutrients in bone health. Written by experts in the areas of nutrition, bone function, and medicine, chapters include research on a variety of bone-related topics including effects of vitamins, nutrients, and antioxidants; dietary requirements; physical exercise; bone hormones; lifestyle and effects through the life cycle; race and ethnicity; and prevention of bone diseases including osteopenia and osteoporosis"-- Provided by publisher.
  • v. 1-2, 2013 Springer
    vol. 2 Springer
    Victor R. Preedy, Lan-Anh Hunter, Vinood B. Patel, editors.
  • 2010 Springer
    edited by Ronald R. Watson, Sherma Zibadi, Victor R. Preedy.
  • 2006 CRCnetBASE
    editors, Yung-Sheng Huang, Yuyoshi Yanagita, Howard R. Knapp.
    Lipid analysis and lipidomics / Magdi M. Mossoba ... [et al.], editors -- An overview of modern mass spectrometry methods in the toolbox of lipid chemists and biochemists / R. Moreau --Techniques and applications in lipid analysis / Nils Hinrichsen and Hans Steinhart -- Recent advances in silver-ion HPLC utilizing acetonitrile in hexane as solvent / R.O. Adlof -- TLC-FID with special reference to marine lipids and other high-molecular-weight organic compounds / R.G. Ackman and A. Timmins -- Analysis of trans-18:1 fatty acids by silver ion HPLC / P. Delmonte and M.P. Yurawecz -- Lipid separations using packed-column SFC / D.G. Hayes -- LC-MS and chiral separation / A. Kuksis -- LC-MS and lipid oxidation / A. Kuksis -- Structural analysis of unsaturated fatty acid methyl ester isomers with acetonitrile covalent adduct chemical ionization (CACI) / J.T. Brenna -- Fast GC for cellular FAME analysis of bacteria / J.S. Buyer -- Use of cellular fatty acids to identify food-borne pathogens by infrared spectroscopy and capillary GC / M.M. Mossoba -- Infrared spectroscopy and partial least square calibration in the simultaneous quantification of isolated trans and conjugated linoleic acids / Alfred A. Christy -- Global cellular lipidome analyses by shotgun lipidomics using multidimensional mass spectrometry / X. Han and R.W. Gross -- Waxes and sterols / E.J. Paris and A.D. Bell -- Analysis of biological tissue and edible fat / J.K.G. Kramer -- Investigation of protein-lipid interactions by vibrational spectroscopy / E.C.Y. Li-Chan, G. Meng, and N.K. Howell -- Fat replacers / W.E. Artz -- High-performance size-exclusion chromatography for lipid analysis in organic media / M.C. Dobarganes and G. Marquez-Ruiz -- Phospholipids / M.C. Erickson.
  • 2012 CRCnetBASE
    edited by Susan Cho, Nelson Almeida.
    "Preface: Fiber offers a variety of health benefits and is essential to reduce the risk of such chronic diseases as diabetes, obesity, cardiovascular disease, and diverticulitis. According to the Institute of Medicine (IOM), adequate intake (AI) of total fiber should be 14 g/1000 kcal. The IOM recommendation is joined by those from a variety of government public health agencies that promote increased fiber consumption, but a majority of people in developed countries still fall short of recommended values. On average, Americans consume only half of required intake, and approximately 90% of the U.S. population fails to meet AI goals. The problem stems largely from the fact that most conventional high-fiber foods are not tasty. Their organoleptic properties lack the kind of sensory attributes that people seek in the foods they eat. This makes it imperative for food companies to formulate tasty foods with high fiber content to improve population-wide consumption. Many have done so with new fiber ingredients that satisfy consumer demands while also delivering the health benefits of fiber. This book discusses findings from the Ninth Vahouny Fiber Symposium, which was held in Bethesda, Maryland, in June 2010. It includes a definition of fiber developed through expert consensus and delves into the many health benefits of fiber, including its prebiotic effects and roles in weight management, glycemic control, cardiovascular health, and intestinal regularity. It also reviews a variety of fiber ingredients that can be used in many appealing foods. The book provides details of claim opportunities for fiber ingredients and fiber-containing foods as well as a list of global suppliers of these ingredients. It is designed for use by food product developers, nutritionists, dietitians, and regulatory agencies"--Provided by publisher.
  • USDA
    U.S. Department of Health and Human Services, U.S. Department of Agriculture.
  • 1983-
    [William R. Harlan ... et al.].
    pt. 1. Blood pressure correlates -- pt. 2. Serum urate, serum cholesterol, and correlates
  • 2010 Springer
    Gabriella Calviello, Simona Serini, editors.
  • 2012 Springer
    Amlan K. Patra, editors.
    An Overview of Antimicrobial Properties of Different Classes of Phytochemicals / Amlan Kumar Patra -- Antimicrobial Properties of Flavonoids / Luisa Pistelli and Irene Giorgi -- Antiviral Properties of Phytochemicals / Ai-Lin Liu and Guan-Hua Du -- Antimicrobial Properties of Organosulfur Compounds / Osman Sagdic and Fatih Tornuk -- Antimicrobial Activities of Essential Oils / Danuta Kalemba, Martyna Matla and Anna Smętek -- Phytochemicals Against Drug-Resistant Microbes / Manuel Sim{tilde}oes, Madalena Lemos and Lúcia C. Sim{tilde}oes -- Phytochemicals as Anti-microbial Food Preservatives / Mehrdad Tajkarimi and Salam A. Ibrahim -- Dietary Tannins on Microbial Ecology of the Gastrointestinal Tract in Ruminants / Amlan Kumar Patra, Byeng-Ryel Min and Jyotisna Saxena -- Manipulating Ruminal Biohydrogenation by the Use of Plants Bioactive Compounds / Valentina Vasta and Rui J. B. Bessa -- Essentials Oils and Rumen Microbial Populations / Malgorzata Szumacher-Strabel and Adam Cieślak -- Saponins: Effects on Rumen Microbial Ecosystem and Metabolism in the Rumen / Elizabeth Wina -- Effect of Plant Secondary Metabolites on Rumen Methanogens and Methane Emissions by Ruminants / Devki Nandan Kamra, Mahesh Pawar and Beddyuti Singh -- Phytochemicals and Gut Microbial Populations in Non-ruminants / Artabandhu Sahoo and Nira Manik Soren.
  • 2012 CRCnetBASE
    edited by Lonnie Michael Lowery, Jose Antonio.
    "There has been a long standing controversy in the field of sports nutrition regarding the role of protein and protein metabolism in muscle development and athletic performance. The understanding of protein nutrition has changed dramatically over the last decade and this book aims to clarify and modernize the topic. This book presents the efficacy, safety, and recommendations of protein intake among strength athletes. Including case studies, the text covers historical perspectives of protein use; safety of high protein diets; specific protein types and timing of intake; weight control using protein; protein synthesis and breakdown; and nitrogenous compounds/supplements"--Provided by publisher.
  • 2005 NAP
    Panel on Macronutrients, Panel on the Definition of Dietary Fiber, Subcommittee on Upper Reference Levels of Nutrients, Subcommittee on Interpretation and Uses of Dietary Reference Intakes, and the Standing Committee on the Scientific Evaluation of Dietary Reference Intakes, Food and Nutrition Board.
    Also available: Print – 2005
  • 2009/2010
    Eric Lieberman Greer.
    Status: Not Checked OutLane Catalog Record
  • 2002 NAP
    Committee on Dietary Risk Assessment in the WIC Program, Food and Nutrition Board, Institute of Medicine.
    Also available: Print – 2002
  • 2012 Springer Protocols
    edited by Rainer Cramer, Reiner Westermeier.
    Part I Fundamentals -- DIGE : past and future / Jonathan S. Minden -- Basics of 2D DIGE / Phil Beckett -- Multifluorescence 2D gel imaging and image analysis / Ingo Vormbrock, Sonja Hartwig, and Stefan Lehr -- Assessing signal-to-noise in quantitative proteomics : multivariate statistical analysis in DIGE experiments / David B. Friedman -- Analysis of proteins using DIGE and MALDI mass spectrometry / Witold M. Winnik [and others] -- Synthesis and validation of cyanine-based dyes for DIGE / Michael E. Jung [and others] -- Part II Methods -- 2D DIGE saturation labeling for minute sample amounts / Georg J. Arnold and Thomas Frohlich -- Proteomic analysis of redox-dependent changes using cysteine-labeling 2D DIGE / Hong-Lin Chan, John Sinclair, and John F. Timms -- Analysis of protein posttranslational modifications using DIGE-based proteomics / Robert M. DeKroon [and others] -- Comparative analyses of protein complexes by blue native DIGE / Katrin Peters and Hans-Peter Braun -- 2D DIGE analysis of protein extracts from muscle tissue / Cecilia Gelfi and Sara De Palma -- Combination of highly efficient hexapeptide ligand library-based sample preparation with 2D DIGE for the analysis of the hidden human serum/plasma proteome / Sonja Hartwig and Stefan Lehr -- 2D DIGE analysis of serum after fractionation by proteominertm beads / Cynthia Liang, Gek San Tan, and Maxey C.M. Chung -- Study design in DIGE-based biomarker discovery / Alexandra Graf and Rudolf Oehler -- Comparative 2D DIGE analysis of the depleted serum proteome for biomarker discovery / Megan Penno, Matthias Ernst, and Peter Hoffmann -- Part III Applications in clinical proteomics -- Differential gel-based proteomic approach for cancer biomarker discovery using human plasma / Keun Na [and others] -- 2D DIGE for the analysis of RAMOS cells subproteomes / Marisol Fernandez and Juan Pablo Albar -- Application of saturation labeling in lung cancer proteomics / Gereon Poschmann [and others] -- Proteomic profiling of the epithelial-mesenchymal transition using 2D DIGE / Rommel A. Mathias, Hong Ji, and Richard J. Simpson -- Method for protein subfractionation of cardiovascular tissues before DIGE analysis / Athanasios Didangelos, Xiaoke Yin, and Manual Mayr -- Application of DIGE and mass spectrometry in the study of type 2 diabetes mellitus mouse models / Celia Smith, Davinia Mills, and Rainer Cramer -- Evaluating the efficacy of subcellular fractionation of blast cells using live cell labeling and 2D DIGE / Yin Ying Ho [and others] -- Part IV Applications in animal, plant, and microbial proteomics -- DIGE analysis of plant tissue proteomes using a phenolic protein extraction method / Christina Rode [and others] -- Native DIGE of fluorescent plant protein complexes / Veronika Reisinger and Lutz Andreas Eichacker -- Overview of 2D DIGE analysis of marine (environmental) bacteria / Ralf Rabus -- Application of 2D DIGE in animal proteomics / Ingrid Miller.
  • prepared by Anthony Oreglia and Janet Ciarcia.
    Also available: Print – 1996.
  • 2007
    Catherine Cavallaro Goodman, Teresa E. Kelly Snyder.
    Status: Not Checked OutLane Catalog Record
  • 2012 Springer
    Scott M. Jackson, Lee T. Nesbitt.
    1. The Chief Complaint -- 2. The Past Medical History, Social History, and Review of Systems -- 3. The Physical Exam -- 4. The Biopsy -- 5. The Laboratory Results -- 6. The Diagnosis -- 7. Glossary.
  • 2008 Springer
    by Scott Jackson, Lee T. Nesbitt.
  • 2012 Thieme Book
    Francis A. Burgener, MD, Professor of Radiology, University of Rochester Medical Center, Rochester, New York, USA, Steven P. Meyers, MD, PhD, Professor of Radiology and Neurosurgery, University of Rochester Medical Center, Rochester, New York, USA, Christopher Herzog, MD, MBA, Department of Radiology, Rotkreuzklinikum, Munich, Germany, Wolfgang Zaunbauer, MD, Institute for Radiology, Kantonsspital St. Gallen, St. Gallen, Switzerland ; In collaboration with Grégory Dieudonné, MD, Scott A. Mooney, MD, Richard T. White, DO.
    "This unique, findings-oriented guide to computed tomography is organized to reflect the way radiologists really work: progressing from general impressions to definitive diagnoses. In nearly 1000 high-quality scabs, the radiologist will find CT findings depicting frequently encountered congenital and acquired diseases and disorders. Included in the wide-ranging survey of CT findings are traumatic injuries; congenital anomalies; and infectious, inflammatory, neoplastic, and degenerative disease processes. For convenience, these are grouped anatomically by brain, head and neck, spine, musculoskeletal system, chest, abdomen, and pelvis. In addition, the book's extensive index systematically cross-references diseases and CT findings, providing even greater accessibility to key information"--Provided by publisher.
  • 2008 Thieme Book
    Francis A. Burgener, Martti Kormano, Tomi Pudas.
    Bone. Osteopenia / Francis A. Burgener -- Osteosclerosis / Francis A. Burgener -- Periosteal reactions / Francis A. Burgener -- Trauma and fractures / Francis A. Burgener -- Localized bone lesions / Francis A. Burgener -- Joint diseases / Francis A. Burgener -- Joint and soft-tissue calcification / Martti Kormano and Tomi Pudas -- Skull / Francis A. Burgener -- Orbits / Francis A. Burgener -- Nasal fossa and paranasal sinuses / Francis A. Burgener -- Jaws and teeth / Francis A. Burgener -- Spine and pelvis / Martti Kormano and Tomi Pudas -- Clavicles, ribs, and sternum / Martti Kormano and Tomi Pudas -- Extremities / Francis A. Burgener, Martti Kormano, and Tomi Pudas -- Hands and feet / Martti Kormano and Tomi Pudas -- Chest. Cardiac enlargement / Martti Kormano and Tomi Pudas -- Mediastinal or hilar enlargement / Martti Kormano and Tomi Pudas -- Pleura and diaphragm / Martti Kormano and Tomi Pudas -- Intrathoracic calcifications / Martti Kormano and Tomi Pudas -- Alveolar infiltrates and atelectasis / Francis A. Burgener -- Interstitial lung disease / Francis A. Burgener -- Pulmonary edema and symmetrical bilateral infiltrates / Francis A. Burgener -- Pulmonary nodules and mass lesions / Francis A. Burgener -- Pulmonary cavitary and cystic lesions / Francis A. Burgener -- Hyperlucent lung / Martti Kormano and Tomi Pudas -- Abdomen. Abnormal abdominal gas patterns and dilatation and motility disorders in the gastrointestinal tract / Francis A. Burgener and Martti Kormano -- Abdominal calcifications / Martti Kormano and Francis A. Burgener -- Abnormal mucosal pattern in the gastrointestinal tract / Martti Kormano and Tomi Pudas -- Narrowing in the gastrointestinal tract / Francis A. Burgener -- Filling defects in the gastrointestinal tract / Francis A. Burgener -- Ulcers, diverticula, and fistulas in the gastrointestinal tract / Martti Kormano and Tomi Pudas -- Gallbladder and bile duct abnormalities / Francis A. Burgener -- Abnormal renal papillae and calices / Francis A. Burgener -- Filling defects in the urinary tract / Francis A. Burgener -- Urinary tract obstructuion and dilatation / Francis A. Burgener.
  • v. 1-2, 1992-2001.
    A. Bernard Ackerman ... [et al.].
    Status: Not Checked OutLane Catalog Record
  • 2007 Thieme Book
    [edited by] Walter Siegenthaler ; with contributions by A. Aeschlimann ... [et al.] ; specialist consultants, A. Aeschlimann ... [et al.].
  • 2007 Ovid
    Adam Greenspan, Gernot Jundt, Wolfgang Remagen.
    Radiologic and pathologic approach to bone tumors -- Bone-forming (osteogenic) lesions -- Cartilage (chondrogenic) lesions -- Fibrogenic, fibroosseous, and fibrohistiocytic lesions -- Round cell lesions -- Vascular lesions -- Miscellaneous tumors and tumor-like lesions -- Metastases -- Tumors and tumor-like lesions of the joints.
    Also available: Print – 2007
  • 2013 Springer
    Ernesto Bonifazi.
    Differential diagnosis in pediatric dermatology requires not only a direct experience in the field, but also an inclination to symptoms observations and analysis.This book, the first exclusively devoted to this topic, covers the full range of relevant conditions: inherited skin disorders; nevi; viral, bacterial, fungal, and parasitic infections; acne; allergic diseases; autoimmune skin disorders; connective tissue diseases; tumors; and miscellaneous conditions. Each chapter addresses the differential diagnosis between two (or occasionally three or four) dermatological conditions. All chapters are just two pages long, containing between two and six images and a very short text emphasizing the clinical differences between the diseases in question. At the end of each chapter, a summary highlights one or two characteristics essential for the differential diagnosis. The volume will represent an ideal tool for pediatric dermatologists, pediatricians, and GPs, and will help them in the diagnosic process.
  • 201 Thieme Book
    [edited by] Rick R. van Rijn, MD, PhD, Paediatric radiologist, Department of Radiology, Academic Medical Centre Amsterdam, Amsterdam, the Netherlands, Johan G. Blickman, MD, PhD, FACR, Professor and Associate Chairman, Department of Imaging Sciences URMC, Director of Pediatric Radiology, Golisano Childrens Hospital, Rochester, New York.
    "Efficiency is the key word at the heart of the concept for this diagnostic atlas - efficiency of presentation and diagnostic efficiency achieved through its use. The contents are arranged in chapters according to organ or body part. Each chapter begins with a list of the radiographic findings referring to the relevant table/page number for that finding. The text within these tables is presented under three columns: possible diagnoses, radiographic findings, and general comments. Corresponding sample images of the highest quality are then provided for the more common conditions throughout. Rare diseases are marked with asterisks and are illustrated where appropriate. The hard-pressed radiologist will welcome this work as an efficient and reliable guide to the interpretation of pediatric images"--Provided by publisher.
  • 2008 Ovid
    R. Douglas Collins.
    Also available: Print – 2008
  • 2012 Ovid
    [edited by] R. Douglas Collins.
  • 2006 Thieme Book
    Guenter Schmidt ; with contributions by Barbara Beuscher-Willems ... [et al.].
    Also available: Print – 2006
  • 2012 ClinicalKey
    Robert H. Seller, Andrew B. Symons.
    This 6th Edition, by Drs. Robert H. Seller and Andrew B. Symons, helps you quickly and efficiently diagnose the 36 most common symptoms reported by patients. Organized alphabetically by presenting symptom, each chapter mirrors the problem-solving process most physicians use to make a diagnosis. It's a practical, clinically oriented approach that can help you master the differential diagnosis of common symptoms and diagnose almost all the problems typically seen in your practice. Find the guidance you need quickly through an alphabetical organization by presenting symptom and a concise, consistent, user-friendly approach that mirrors the diagnostic decision-making process. Get a fresh perspective from new co-author, Dr. Andrew B. Symons, who brings a strong background in education as Vice Chair of Medical Student Education at SUNY Buffalo.
  • 2007
    Robert H. Seller.
    Status: Not Checked OutLane Catalog Record
  • 2014 Springer
    Abdul Qayyum Rana, Peter Hedera.
    This practical, pocket-sized, quick reference book is for those who need to manage movement disorder patients without the immediate help of a movement disorder neurologist. Only the most pertinent information is covered. This book is divided into five chapters covering the common phenomenology of movement disorders and includes tremor, dystonia, chorea, myoclonus, and tics. The etiology, pathophysiology, symptoms and treatments of these conditions are briefly reviewed, with the emphasis on the most common practical challenges encountered with these patients. Differential Diagnosis of Movement Disorders in Clinical Practice is aimed at postgraduates training in neurology, emergency care physicians, internists and primary care providers. Medical students will also find this book particularly helpful during their neurology rotations.
  • 2005 Springer Protocols
    edited by Peng Liang, Jonathan D. Meade, Arthur B. Pardee.
    Global analysis of gene expression by differential display : a mathematical model / Shitao Yang and Peng Liang -- Automation of fluorescent differential display with digital readout / Jonathan D. Meade ... [et al.] -- Ordered differential display / Mikhail V. Matz and Ella A. Meleshkevitch -- GeneCalling : transcript profiling coupled to a gene database query / Richard A. Shimkets -- High-density sampling differential display of prokaryotic mRNAs with RAP-PCR / Dana M. Walters and Pierre E. Rouviere -- Vertical arrays : microarrays of complex mixtures of nucleic acids / Rosana Risques ... [et al.] -- Automated pattern ranking in differential display data analysis / Tero Aittokallio ... [et al.] -- Linking cDNA-AFLP-based gene expression patterns and ESTs / Ling Qin, Pjotr Prins, and Johannes Helder -- Differentially expressed genes associated with hepatitis B virus HBx and MHBs protein function in hepatocellular carcinoma / Dae-Ghon Kim -- Identification of disease markers by differential display : prion disease / Michael Clinton ... [et al.] -- Saturation screening for p53 target genes by digital fluorescent differential display / Yong-Jig Cho ... [et al.] -- Identification of p53-regulated genes by the method of differential display / Yunping Lin, Roger P. Leng, and Samuel Benchimol -- Identification by differential display of IL-24 autocrine loop activated by ras oncogenes / Zhongjia Tan, Mai Wang, and Peng Liang -- Comprehensive analysis of ovarian gene expression during ovulation using differential display / Lawrence L. Espey -- Functional analysis of nocturnin : a circadian clock-regulated gene identified by differential display / Julie E. Baggs and Carla B. Green -- Isolation and characterization of anthocyanin 5-0-glucosyltransferase in perilla frutescens var. crispa by differential display / Mami Yamasaki and Kazuki Saito -- Identification of target genes of a yeast transcriptional repressor / Bernard Mai and Linda L. Breeden -- Detection of an mRNA polymorphism by differential display / Shan Liang ... [et al.] -- Silencing in yeast : identification of CLr4 targets / Sergey V. Ivanov and Alla V. Ivanova -- Identification of mRNA bound to RNA binding proteins by differential display / Anne Carr-Schmid, Xinfu Jiao, and Megerditch Kiledjian.
  • 2013 Springer
    David B. Glick, Richard M. Cooper, Andranik Ovassapian, editors.
    The Difficult Airway provides comprehensive textual and visual coverage of how to deal with patients who have expected or unexpected difficult airways. The book begins with a review of current definitions of the difficult airway, its incidence, and the evolution of algorithms to facilitate its management. The chapters that follow offer a comprehensive update on the techniques and concepts described in the American Society of Anesthesiologists' Difficult Airway Algorithm. Noted experts in each of the techniques have been recruited by the book editors to present the information. Figures throughout the book illustrate important points and procedures. This is a wonderful resource for health care professionals who are concerned with the management of the difficult airway, including anesthesiologists, intensive care physicians, emergency room physicians, nurses, and out-of-hospital first responders.
  • 2015 Springer
    Jorge L. Alió, Dimitri T. Azar, Alessandro Abbouda, Amr El Aswad, editors.
    This richly illustrated book is intended as a gold standard for the refractive surgeon. It complements the authors? successful previous book, Management of Complications in Refractive Surgery, by providing detailed practical information on the management of specific cases. Worldwide leaders in the field document a wide range of challenging cases drawn from their own clinical practice. These cases relate to the planning of refractive laser treatment; intraoperative complications when using LASIK (Microkeratome and Femtosecond) and various surface treatments, including PRK, PTK, and EpiLASIK; early and late postoperative complications with these treatments; and a range of other complications that may arise during or after refractive surgery. This book will be an indispensable aid for the refractive surgeon and will assist in decision making when the surgeon is confronted by a difficult case.
  • 2013 Springer
    Ahmed M. Al-Kandari, Mahesh Desai, Ahmed A. Shokeir, Ahmed M. Shoma, Arthur D. Smith, editors.
    1. Introduction / Ahmed M. Al-Kandar -- 2. Anesthetic Considerations During Endourologic Surgery / Ahmed M. Labib and Ahmed M. Al-Kandari -- 3. Difficulties in Instrumentation of Endourologic Procedures / Ahmed M. Al-Kandari -- 4. Percutaneous Management of Calyceal Diverticula: An American Experience / Jessica A. Mandeville, Ehud Gnessin, and James E. Lingeman -- 5. Managing Bleeding During Percutaneous Renal Surgery / Ahmed R. El-Nahas, Ahmed M. Shoma, and Ahmed A. Shokeir -- 6. Septic Complications During Percutaneous Nephrolitholotomy (PCNL) / Evangelos Liatsikos and Panagiotis Kallidonis -- 7. Visceral Complications of Percutaneous Nephrolithotomy (PCNL) / Abdelghaffar S. Arafa and Ahmed M. Al-Kandari -- 8. Percutaneous Nephrolithotomy (PCNL) for Staghorn Calculi: The Rigid Approach: Overcoming the Difficulties / Arvind P. Ganpule and Mahesh Desai -- 9. Flexible Renal Nephroscopy: Overcoming the Difficulties / Joseph A. Graversen, Adam C. Mues, and Mantu Gupta -- 10. Chinese Minimally Invasive Percutaneous Nephrolithotomy (MPCNL): Overcoming the Difficulties / Zhaohui He, Guohua Zeng, and Xun Li -- 11. Percutaneous Renal Surgery for Renal Pelvic Tumors: Overcoming the Difficulties / Brian Duty, Michael Blute, Zhamshid Okhunov, Arthur D. Smith, and Zeph Okeke -- 12. Percutaneous Nephrolithotomy (PCNL) in the Treatment of Stones within Horseshoe Kidneys and in Patients with Autosomal Dominant Polycystic Kidney Disease / Ahmed Abed, Ahmed R. El-Nahas, Ahmed M. Al-Kandari, and Ahmed A. Shokeir -- 13. Drainage Systems After Percutanous Renal Procedures / Brian Duty, Zhamshid Okhunov, Arthur D. Smith, and Zeph Okeke -- 14. Retrograde Nephrostomy Access: Overcoming the Difficulties / Khalid Matar Al-Otaibi -- 15. Percutaneous Nephrolithotomy (PCNL): The Supine Approach: Overcoming the Difficulties / Francisco Pedro Juan Daels -- 16. Percutaneous Nephrolithotomy (PCNL) in Obese Patients: Overcoming the Difficulties / Soroush Rais-Bahrami and Arthur D. Smith -- 17. Percutanous Nephrolithotomy (PCNL) for Caliceal Diverticulum: An Egyptian Experience / Ahmed Mohamed Elshal, Ahmed M. Shoma, and Ahmed A. Shokeir -- 18. Endourological Management of Urological Complications Following Renal Transplantation / Ahmed S. El-Hefnawy, Mohamed M. Elsaadany, Shady A. Soliman, Yasser Osman, Ahmed M. Shoma, and Ahmed A. Shokeir -- 19. Difficult Situations in Percutaneous Nephrolithotomy (PCNL) for Solitary Kidney and Renal Failure / Arvind P. Ganpule, Amit Satish Bhattu, and Mahesh Desai -- 20. Percutaneous Nephrolithotomy (PCNL) and Other Simultaneous Procedures / Ravindra B. Sabnis, Raguram Ganesamoni, and Amit Doshi -- 21. Adult Endopyelotomy: Overcoming the Difficulties / Zhamshid Okhunov, Brian Duty, Zeph Okeke, and Arthur D. Smith -- 22. Ureteroscopy for Upper Ureteral Stones: Overcoming the Difficulties of the Rigid Approach / Tamer S. Barakat, Ahmed R. El-Nahas, Ahmed M. Shoma, and Ahmed A. Shokeir -- 23. Uretheroscopy for Upper Ureteric and Renal Stones: Overcoming Difficulties with the Flexible Approach / Jacob Howard Cohen and Michael Grasso III -- 24. Ureteroscopy for Ureteral Strictures / Ahmed M. Harraz, Ahmed M. Shoma, and Ahmed A. Shokeir -- 25. Ureteroscopic Management of Ureteral and Renal Pelvic Tumors: Overcoming the Difficulties / Demetrius H. Bagley and Kelly A. Healy -- 26. Endourologic Management of Non-Malignant Bilharzial Urinary Complications / Hamdy Mohamed Ibrahim, Ahmad Samy Bedair, and Ahmed M. Al-Kandari -- 27. Ureteroscopy During Pregnancy / Hamdy Mohamed Ibrahim and Ahmed M. Al-Kandari -- 28. Pediatric Percutaneous Nephrolithotomy (PCNL): Overcoming the Difficulties / Sinan Zeren and Hakan Çakir -- 29. Pediatric Ureteroscopy: Overcoming the Difficulties / Raguram Ganesamoni, Shashikant Mishra, and Mahesh Desai -- 30. Difficulties with Ureteral Stents / Brandon K. Isariyawongse and Manoj Monga -- 31. Overcoming the Cost Difficulties in Endourology / Ravindra B. Sabnis -- 32. Difficulties in Endourologic Training / Ahmed M. Al-Kandari -- 33. Avoiding and Overcoming Medico-Legal Difficulties in Endourology / Donnaline Richman and James H. Robb.
  • 2011 Springer
    Ahmed M. Al-Kandari, Inderbir S. Gill (editors).
    Difficulties in Laparoscopic Access -- Difficulties in Anesthesia for Urologic Laparoscopy -- Difficulties in Urologic Laparoscopic Instrumentation -- Cost-Reductive Measures in Laparoscopy: Tips and Tricks for Developing Countries -- Difficulties in Laparoscopic Simple Nephrectomy -- Difficulties in Transperitoneal Laparoscopic Radical Nephrectomy -- Difficulties in Retroperitoneal Laparoscopic Radical Nephrectomy -- Difficulties in Laparoscopic Live Donor Nephrectomy -- Difficulties in Laparoscopic Nephroureterectomy -- Difficulties in Laparoscopic Partial Nephrectomy -- Difficulties in Laparoscopic Adrenalectomy -- Difficulties in Laparoscopic Renal Cyst Removal and Giant Hydronephrosis Nephrectomy -- Difficulties in Laparoscopic Simple Prostatectomy -- Difficulties in Laparoscopic Radical Prostatectomy -- Difficulties in Robotic Radical Prostatectomy -- Difficulties in Robotic-Assisted Nerve-Sparing Radical Prostatectomy -- Difficulties in Laparoscopic Urologic Surgery in Kidney Transplant Patients and Obese Patients -- Difficulties in Laparoscopic Retroperitoneal Lymph Node Dissection -- Difficulties in Laparoscopic Radical Cystectomy -- Difficulties in Laparoscopic Pyeloplasty -- Difficulties in Laparoscopic Surgery for Urinary Stones -- Difficulties in Laparoscopic Ureteral and Bladder Reconstruction -- Difficulties in Laparoscopic Ureterolysis and Retroperitoneal Lymph Node Dissection -- Difficulties in Laparoscopic Management of Vesicovaginal Fistula -- Difficulties in the Laparoscopic Treatment of Female Genital Prolapse -- Difficulties in Pediatric Laparoscopic Urologic Surgery -- Difficulties in Single-Port Laparoscopic Procedures -- Difficulties in Urologic Laparoscopy Complications -- Difficulties in Laparoscopic Training, Mentoring, and Medico-Legal Issues.
  • 2011 Springer
    Mark K. Ferguson (editor).
  • 2007 Springer
    Mark K. Ferguson, ed.
  • 2014 Springer
    Mark K. Ferguson, editor.
    Introduction -- Evidence Based Medicine: Quality of Evidence and Evaluation Systems -- Decision Analytic Techniques and Other Decision Processes -- Decision Making: The Surgeon's Perspective -- Decision Making: The Patient's Perspective -- Indications for Pretreatment Pathologic Mediastinal Staging in Non-small Cell Lung Cancer -- Preoperative Smoking Cessation for Lung Resection Patients -- High Tech Exercise Testing in Assessing Candidates for Lung Resection -- Management of Perioperative Anticoagulation in Lung Resection -- Perioperative Arrhythmia Prophylaxis for Major Lung Resection -- VATS Versus Open Lobectomy for Stage I or II NSCLC -- Robotic-Assisted Thoracoscopic Surgery (RATS) Versus Video-Assisted Thoracoscopic Surgery (VATS) Lobectomy for Stage I or II Non-small Cell Lung Cancer -- Lobectomy After Induction Therapy for NSCLC in the Presence of Persistent N2 Disease -- Pneumonectomy After Induction Therapy for Non-small Cell Lung Cancer -- Resection Versus SBRT for Stage I Non-small Cell Lung Cancer in Patients with Good Pulmonary Function -- Digital Drainage Systems After Major Lung Resection -- Management of Persistent Post-operative Alveolar Air Leak -- Surveillance After Resection of Stage I Non Small Cell Lung Cancer -- Support Therapy for Lung Failure: The Utility of Device Therapy -- Extracorporeal Support for Lung Grafts Prior to Transplantation -- Pulmonary Metastasectomy -- Optimal Therapy for Barrett High Grade Dysplasia -- Preoperative Chemo Versus Chemoradiotherapy for Regionally Advanced Esophageal Adenocarcinoma -- The Role of Surgery in the Management of Regionally Advanced Esophageal Squamous Cell Cancer -- Optimal Surgical Approach to Esophagectomy for Distal Esophageal Adenocarcinoma -- Regional Extent of Lymphadenectomy for Esophageal Cancer -- Optimal Lymph Node Dissection in Esophageal Cancer -- Salvage Esophagectomy for Persistent or Recurrent Disease After Definitive Chemoradiotherapy -- Gastric Emptying Procedure After Esophagectomy -- Postoperative Adjuvant Therapy After Resection of Regionally Advanced Esophageal Cancer -- Prophylactic Antireflux Surgery in Lung Transplantation -- Surgical Versus Endoscopic Management for Esophageal Perforations -- Stents for Esophageal Anastomotic Leak -- Management of Small Esophageal GIST Tumors -- Surgery for Minimally Symptomatic Pulsion Diverticula of the Thoracic Esophagus -- Partial Versus Total Fundoplication for GERD in Patients with Normal Esophageal Motility -- Diaphragm Pacing -- Minimally Invasive Versus Open Repair of Giant Paraesophageal Hernia -- Synthetic Reinforcement of Diaphragm Closure for Large Hiatal Hernia Repair -- Diaphragmatic Plication for Eventration -- Management of Minimally Symptomatic Recurrent Hiatal Hernia -- Stenting for Benign Airway Obstruction -- Bioengineered Tissues for Tracheal Reconstruction -- Percutaneous Versus Standard Tracheostomy in the Critically Ill Adult -- Carinal Resection for Non Small Cell Lung Cancer -- Management of Persistent Postoperative Air Leaks -- Fibrinolytics for Managing Pleural Empyema -- VATS Versus Open Management of Pleural Empyema -- Optimal Management of Symptomatic Malignant Pleural Effusion -- Pleurectomy Versus Radical Pleuropneumonectomy for Malignant Pleural Mesothelioma -- Surgical and Medical Therapy for Malignant Pleural Mesothelioma -- Extended Versus Standard Thymectomy for Myasthenia Gravis -- Optimal Approach for Resection of Encapsulated Thymoma: Open Versus VATS -- Robotic Versus VATS Thymectomy for Encapsulated Thymoma -- Video Mediastinoscopy Versus Standard Mediastinoscopy -- Debulking for Extensive Thymoma -- Surgery for Palmar Hyperhidrosis: Patient Selection and Extent of Surgery -- Synthetic Versus Biologic Reconstruction of Bony Chest Wall Defects -- Management of Flail Chest -- Management of Pectus Deformities in Adults.
  • 2015 Springer
    Ralph M. Trüeb.
    You could read every textbook available on hair growth and disorders, and still not be able to treat hair loss effectively. In every art, there are many techniques, but few principles. The only way to achieve success is to have a firm foundation of principles to build upon, and the right attitude about how to achieve your goals. This book offers a detailed guide that goes beyond the technical aspects of trichology and evidence based medicine, providing specialists and primary care physicians experienced in the basic management of hair loss with the additional know-how they need to master the ultimate challenge of difficult hair loss patients. First, the prerequisites for successful management of hair loss are reviewed ? basically, making a diagnosis and understanding the patient and his or her problem. Then, guidelines on the management of difficult dermatologic conditions and of psychopathological disorders associated with hair loss are provided. Lastly, important aspects of follow-up are covered?specifically the problems of adverse effects, patient non-compliance, and their management?before concluding with exemplary case studies of successful treatment of alopecia and related conditions.
  • 2014 Springer
    Sergio V. Delgado, Jeffrey R. Strawn.
    This innovative and important book describes a practical and clinically-relevant approach to the 'difficult' psychiatric consultation. The authors systematically examine psychodynamic theories, family systems theories, and legal and ethical aspects of these consultations. Difficult Psychiatric Consultations: An Integrated Approach is unique compared to most psychiatric texts, in that it weaves traditional concepts in understanding a person and their family with contemporary developmental and relational concepts. The importance of these concepts, when applied to the study of the complexities and the interplay between patients, treatment teams and patients' families in today's medical centers, is brought to life through rich, real-life clinical examples. These powerful clinical vignettes allow the reader to put himself in the psychiatric consultant's shoes as he navigates practical interventions to improve the outcomes of 'difficult' consultations. To that end, the authors provide tables to outline pre and post diagnosis observable patterns of the parties involved in the psychiatric consultation. This book has much to offer to general psychiatrists, child and adolescent psychiatrists, psychiatric residents, psychologists, nurse practitioners and social workers.
  • pt. A-B, 1985. ScienceDirect
    pt. B ScienceDirect
    edited by Harold W. Wyckoff, C.H.W. Hirs, Serge N. Timasheff.
    Also available: Print – pt. A-B, 1985.
  • 2013 Springer
    edited by Hugues Duffau.
    The biology, behavior and management of diffuse low-grade gliomas (DLGG) in adults have been matters of controversy for many decades. However, recent technical and conceptual advances in genetics, imaging and treatments have paved the way towards individualized management. In addition, advancing knowledge of brain processing means that it is possible to take into consideration the interaction between the disease (low-grade glioma) and the host (the brain) and thus to modulate the therapeutic strategies with the goal to increase the median survival as well as to improve the quality of life. Diffuse Low-Grade Gliomas in Adults: Natural History, Interaction with the Brain, and New Individualized Therapeutic Strategies presents the latest research pertaining to the diagnosis, therapy and management of diffuse low-grade gliomas (DLGG) in adults, with a particular focus on the path towards individualized therapy for this kind of tumor. Recent research on the natural history of DLGGs and their interaction with the brain has led to new diagnostic and therapeutic strategies which increase survival and quality of life of the patient, and these methods are described in this book. This book uniquely focuses on addressing diffuse low-grade gliomas in adults and is a valuable resource for medical oncologists, neuro-oncologists and neurologists.
  • 2012 Springer
    Robert P. Baughman, Roland M. du Bois, editors.
    Section I. General Considerations -- 1. Patient Evaluation / Keith C. Meyer and Ganesh Raghu -- 2. Radiologic Evaluation / David A. Lynch -- 3. Bronchoalveolar Lavage / Marjolein Drent and Catharina F.M. Linssen -- 4. Pathology of Diffuse Lung Disease / Thomas V. Colby and Kevin O. Leslie -- 5. Pulmonary Function Testing / Athol U. Wells, Simon Ward, and Derek Cramer -- 6. Diffuse Lung Disease: Classification and Evaluation / Harold R. Collard and Talmadge E. King Jr. -- 7. Drug Therapy for Interstitial Lung Disease / Robert P. Baughman, Ulrich Costabel, and Elyse E. Lower -- 8. Pulmonary Hypertension in Interstitial Lung Disease / Oksana A. Shlobin and Steven D. Nathan -- Section II. Specific Diseases -- 9. Sarcoidosis / Daniel A. Culver and Marc A. Judson -- 10. Idiopathic Pulmonary Fibrosis / Joseph P. Lynch III and John A. Belperio -- 11. Nonspecific Interstitial Pneumonia / Kevin R. Flaherty and Fernando J. Martinez -- 12. A Practical Approach to Connective Tissue -- Disease-Associated Lung Disease / Aryeh Fischer and Roland M. du Bois -- 13. Hypersensitivity Pneumonitis: A Clinical Perspective / Moisés Selman, Mayra Mejía, Héctor Ortega, and Carmen Navarro -- 14. Smoking and Interstitial Lung Disease / Joshua J. Solomon and Kevin K. Brown -- 15. Childhood Interstitial Lung Disease / Lisa R. Young -- 16. Rare Interstitial Lung Diseases / Tristan J. Huie, Amy L. Olson, Marvin I. Schwarz, and Stephen K. Frankel -- 17. Occupational- and Drug-Induced Disorders / Michal Pirozynski and John Joseph Borg -- 18. Bronchiolitis / Vincent Cottin and Jean-François Cordier -- 19. Pulmonary Vasculitis / Ulrich Specks and Karina A. Keogh.
  • 2006 Springer
    editors, Mario Maffessanti & Giorgia Dalpiaz ; authors A. Cancellieri ... [et al.].
  • 2015 Springer
    Timothy Craig Allen, editor.
    This volume is the most up-to-date text available on diffuse malignant mesothelioma and includes all the newest imaging modalities, immunohistochemical features, and ever-expanding information on the molecular characteristics of the cancer. In-depth chapters contain fully referenced text as well as detailed tables and images. While the primary audiences for this book are pathologists and pathology residents, the broad examination of diffuse malignant mesothelioma, including its epidemiology, makes this book valuable to radiologists, surgeons, oncologists, and other clinical physicians and their residents as well. Written by experts in the field, Diffuse Malignant Mesothelioma is a concise yet comprehensive resource for clinicians involved in the management of one of the most widely recognized and feared cancers in the world.
  • 2007 Karger
    volume editors, Ulrich Costabel, Roland M. du Bois, Jim J. Egan.
  • 2009 ScienceDirect
    edited by Heidi Johansen-Berg, Timothy E.J. Behrens.
    Introduction to diffusion MRI -- Introduction to diffusion MR -- Pulse sequences for diffusion-weighted MRI -- Gaussian modeling of the diffusion signal -- Multiple fibers : beyond the diffusion tensor -- Diffusion MRI for quantitative measurement -- White matter structure : a microscopist's view -- Biological basis of diffusion anisotropy -- Inferring microstructural information of white matter from diffusion MRI -- Cross-subject comparison of local diffusion MRI parameters -- Diffusion MRI in neurological disorders -- DTI in development and aging -- Individual differences in white matter microstructure in the healthy brain -- Diffusion tensor imaging and its application to schizophrenia and related disorders -- Diffusion MRI for in vivo neuroanatomy -- Classic and contemporary neural tract tracing techniques -- Human connectome: linking structure and function in the human brain -- MR diffusion tractography -- Validation of tractography -- Connectivity fingerprinting of gray matter -- Connectional anatomy of language: recent contributions from diffusion tensor tractography -- Tractography for surgical targeting -- Comparing brain connections in differenct species using diffusion weighted imaging -- Imaging structure and function.
  • 2011
    edited by Derek K. Jones.
    Status: Not Checked OutLane Catalog Record
    The functional anatomy of white matter: from postmortem dissections to in vivo virtual tractography / Marco Catani -- Neurobiology of white matter disorders / Christopher M. Filley -- Invasive methods for tracing white matter architecture / Hubertus Axer -- Physics of diffusion / Paul T. Callaghan -- Magnetic resonance diffusion imaging: introduction and concepts / Denis Le Bihan -- Anisoptropic diffusion: from the apparent diffusion coefficient to the apparent diffusion tensor / Peter J. Basser and Evren Özarslan -- What makes diffusion anisotropic in the nervous system? / Christian Beaulieu -- Biophysics of diffusion in cells / Joseph J.H. Ackerman and Jeffrey J. Neil -- Extracting geometric properties of white matter with q-Space Diffusion MRI (QSI) / Yaniv Assaf and Yoram Cohen -- The cumulant expansion: an overarching mathematical framework for understanding diffusion NMR / Valerij G. Kiselev -- Hardware considerations for diffusion MRI / Nirbhay N. Yadav, Tim Stait-Gardner, and William S. Price -- EPI-based pulse sequences for diffusion tensor MRI / Stefan T. Skare and Roland Bammer -- Non-EPI pulse sequences for diffusion MRI / James G. Pipe -- Phase errors in diffusion-weighted imaging / Roland Bammer ... [et al.] -- Optimal approaches to diffusion MRI acquisition / Derek K. Jones -- Least squares approaches to diffusion tensor estimation / Cheng Guan Koay -- Image distortion and its correction in diffusion MRI / Jesper J.L. Andersson and Stefan T. Skare -- Artifacts in diffusion MRI / Carlo Pierpaoli -- Quality assurance for diffusion MRI / Nicholas G. Dowell and Paul S. Tofts -- Statistical issues in diffusion tensor MRI / Sinisa Pajevic -- Visualization of diffusion MRI data / Alexander Leemans -- Deterministic white matter tractography / Andrew L. Alexander -- Probabilistic fiber tracking / Geoff J.M. Parker -- Connectivity-based parcellation of gray matter / Timothy Behrens ... [et al.] -- Diffusion tensor microimaging and its applications / Jiangyang Zhang ... [et al.] -- Anatomical validation of DTI and tractography / I. Nigel C. Lawes and Christopher A. Clark -- Mathematics of crossing fibers / Daniel Alexander and Kiran K. Seunarine ; The biophysics of crossing fibers / Jacques-Donald Tournier -- Strategies for patient-control comparison of diffusion MR data / Mara Cercignani -- Diffusion tensor MRI in brain development / Petra Hüppi -- Diffusion in acute stroke / Ona Wu ... [et al.] -- Diffusion in chronic stroke and small vessel disease / Michael O'Sullivan -- Diffusion imaging in brain tumors / Aaron S. Field -- Diffusion tensor MRI in multiple sclerosis / Massimo Filippi and Maria A. Rocca -- Diffusion MRI in epilepsy / Khalid Hamandi and Robert Powell -- DTI and tractography in neurosurgical planning / Christopher A. Clark and Tiernan Byrnes -- Diffusion MRI in psychiatric disorders / Tonya White and Kelvin O. Lim -- Diffusion tensor imaging in aging and age-related neurodegenerative disorders / Edith V. Sullivan and Adolf Pfefferbaum -- Diffusion imaging in gray matter / Helen D'Arceuil and Alex de Crespigny -- Diffusion imaging in the optic nerve, spinal cord, and peripheral nerve / Claudia A.M. Wheeler-Kingshott and Olga Ciccarelli -- Diffusion imaging in muscle / Gustav J. Strijkers, Maarten R. Drost, and Klaas Nicolay -- Insights into diffusion tensor imaging from animal models of white matter pathology / Matthew D. Budde and Sheng-Kwei Song -- Reminiscences about the development of Pulsed Field Gradient Spin Echo NMR (PFGSE-NMR) / Ed O. Stejskal and John E. Tanner -- Diffusion, diffraction, and microimaging / Paul T. Callaghan -- Diffusion MRI: conception, birth, and adolescence / Denis Le Bihan -- DWI in cerebral ischemia: the early days / Michael E. Moseley -- Invention and development of Diffusion Tensor MRI (DT-MRI or DTI) at the NIH / Peter J. Basser.
  • 2012 Springer
    Antonio Luna, Ramón Ribes, Jorge A. Soto [editors]
    1. Diffusion-Weighted Imaging: Acquisition and Biophysical Basis / Javier Sánchez-González and Javier Lafuente-Martínez -- 2. How to Identify and Avoid Artifacts on DWI / Javier Sánchez-González -- 3. Quantification and Postprocessing of DWI / Javier Sánchez-González and Antonio Luna -- 4. DWI at 3 T: Advantages, Disadvantages, Pitfalls, and Advanced Clinical Applications / Javier Sánchez-González and Antonio Luna -- 5. DWI of the Liver / Antonio Luna and Luis Luna -- 6. Diffusion-Weighted MR Imaging of the Pancreas / Jorge A. Soto, German A. Castrillon, Stephan Anderson, and Nagaraj Holalkere -- 7. Diffusion-Weighted MR Imaging of the Renal and Adrenal Glands / Nagaraj Holalkere, Stephan Anderson, and Jorge A. Soto -- 8. Diffusion-Weighted Imaging of Prostate, Bladder, and Retroperitoneum / Joan C. Vilanova, Roberto García-Figueiras, Joaquim Barceló, and Antonio Luna -- 9. Use of DWI in Female Pelvis / German A. Castrillon, Stephan Anderson, Nagaraj Holalkere, and Jorge A. Soto -- 10. DWI of the Breast / Joaquim Barceló, Joan C. Vilanova, and Antonio Luna -- 11. Diffusion-Weighted Imaging of the Gastrointestinal Tract and Peritoneum / German A. Castrillon, Stephan Anderson, Jorge A. Soto, and Antonio Luna -- 12. Diffusion-Weighted Imaging of Anorectal Region / Lidia Alcalá, Teodoro Martín, and Antonio Luna -- 13. Diffusion-Weighted Imaging in the Evaluation of Lung, Mediastinum, Heart, and Chest Wall / Antonio Luna, Teodoro Martín, and Javier Sánchez González -- 14. Role of DWI in the Evaluation of Tumors of the Head and Neck and in the Assessment of Lymph Nodes / Inmaculada Rodriguez, Teodoro Martín, and Antonio Luna -- 15. Musculoskeletal Applications of DWI / Joan C. Vilanova, Sandra Baleato, and Elda Balliu -- 16. Whole-Body Applications of DWI / Joan C. Vilanova, Sandra Baleato, Joaquim Barceló, and Antonio Luna.
  • 2016 Springer
    Wim Van Hecke, Louise Emsell, Stefan Sunaert, editors.
    Part I: Introduction -- How to Use This Book -- Introduction to Diffusion Tensor Imaging -- Part II: Diffusion Tensor Imaging: From Theory to Practice -- Concepts of Diffusion in MRI -- From Diffusion to the Diffusion Tensor -- Quantitative DTI Measures -- Survivor's Guide to DTI Acquisition -- Checking and Correcting DTI Data -- Part III: Diffusion Tensor Imaging Analysis -- Strategies and Challenges in DTI Analysis -- DTI Analysis Methods: Region of Interest Analysis -- DTI Analysis Methods: Voxel-based Analysis -- DTI Analysis Methods: Fibre Tracking and Connectivity -- Part IV: Normal Diffusion Tensor Imaging Anatomy -- Normal Diffusion Tensor Imaging-based White Matter Anatomy -- Part V: Clinical Applications of Diffusion Tensor Imaging -- DTI in Clinical Practice: Opportunities and Considerations -- DTI in Neurosurgical Planning -- DTI in Diagnosis and Follow-up of Brain Tumors -- The Role of DTI in Multiple Sclerosis and Other Demyelinating Conditions -- DTI in Dementing Conditions -- DTI in Psychiatry -- Diffusion Tensor Imaging in Traumatic Brain Injury -- Part VI: Beyond Diffusion Tensor Imaging -- High Angular Resolution Diffusion Imaging -- Diffusion Kurtosis Imaging -- Glossary. .
  • 2013 Springer
    Bram Stieltjes, Romuald M. Brunner, Klaus H. Fritzsche, Frederik B. Laun.
    Diffusion Tensor Imaging (DTI) is a variation of diffusion-weighed imaging. Particularly in the neurosciences, this technique has gained tremendous momentum in the past decade, both from a technical point of view as well as in its applications. DTI is mainly used in neurological diagnosis and psychiatric and neurologic research, e.g. in order to locate brain tumors and depict their invasivity. DTI offers a unique in-vivo insight into the three-dimensional structure of the human central nervous system. While easy interpretation and evaluation is often hampered by the complexity of both the technique and neuroanatomy, this atlas helps you recognize every one of the important structures rapidly and unambiguously.In the introduction, this atlas provides a concise outline of the evolution of diffusion imaging and describes its potential applications. In the core part of the atlas, the neuroanatomically important structures are clearly labeled both on DTI-derived color maps and conventional MRI. Complex fiber architecture is illustrated schematically and described concisely in textboxes directly on the relevant page. In the final part of the atlas, a straightforward, step-by-step approach for the three-dimensional reconstruction of the most prominent fiber structures is given, and potential pitfalls are indicated.The atlas aims at neuroscientists, neuroanatomists, neurologists, psychiatrists, clinical psychologists, physicists, and computer scientists. For advanced users, the atlas may serve as a reference work, while students and scientists are thoroughly introduced into DTI.
  • 2016 Thieme-Connect
    [edited by] Claudia da Costa Leite, Mauricio Castillo.
    Physics of DTI and DWI / Maria Concepción Garcia Otaduy -- Brain edema : phatophysiology / Falgun H. Chokshi and Amit M. Saindane -- Supratentorial white matter tracts and their organization / -- Christopher P. Hess and Jason M. Johnson -- DWI and DTI of the brain during early brain development : the first two years of life / Wei Gao, John H Gilmore, and Weili Lin -- DWI and DTI in aging / Andrew Joseph Degnan and Lucien M. Levy -- DWI in vascular pathology / Sangam Kanekar and Chandan Misra -- Diffusion weighted-imaging in the evaluation of brain tumors / Fernanda C. Rueda-Lopes, Celso Hygino da Cruz Jr, and Emerson L. Gasparetto -- DWI and DTI in infectious diseases / Claudia da Costa Leite, Maria da Graça Morais Martin, and Mauricio Castillo -- DWI and DTI in demyelination and toxic diseases / Celi dos Santos Andrade, Carolina de Medeiros Rimkus, Claudia da Costa Leite, Alexander M.McKinney, Leandro Tavares Lucato -- DWI and DTI of white matter diseases in children / Julie H. Harreld and Zoltan Patay -- Diffusion imaging for the assessment of traumatic brain injury (TBI) / Michael L. Lipton -- DWI in hemmorrhage / Joana Ramalho and Mauricio Castillo -- DWI and DTI in spine and spinal cord diseases / Majda Thurnher -- DWI and DTI in head and neck diseases / Eloisa M Santiago Gebrim, Regina Lucia Elia Gomes, Flavia K Issa Cevasco, Marcio Ricardo Taveira Garcia -- Future applications of DWI-diffusional kurtosis and other non-Gaussian diffusion techniques / Maria Gisele Matheus.
  • 2005 Springer
    T. Moritani, S. Ekholm, P.-L. Westesson.
  • 2009 Springer
    T. Moritani, S. Ekholm, P.-L. Westesson.
  • 2008
    Victor P. Eroschenko.
    Status: Not Checked OutLane Catalog Record
  • 2013
    Victor P. Eroschenko.
    Status: Not Checked OutLane Catalog Record
    Histologic methods -- Light and transmission electron microscopy -- Cells and the cell cycle -- Epithelial tissue -- Connective tissue -- Hematopoietic tissue -- Skeletal tissue : cartilage and bone -- Muscle tissue -- Nervous tissue -- Circulatory system -- Immune system -- Integumentary system -- Digestive system part I : oral cavity and major salivary glands -- Digestive system part II : esophagus and stomach -- Digestive system part III : small and large intestines -- Digestive system part IV : accessory digestive organs -- Respiratory system -- Urinary system -- Endocrine system -- Male reproductive system -- Female reproductive system -- Organs of special senses : visual and auditory systems.
  • 2014 Springer
    Rafael Toledo, Bernard Fried, editors.
    Part 1. General aspects of trematodes. Form and function in the Digenea / Robert C. Peoples and Bernard Fried -- The systemics of the Trematoda / Aneta Kostadinova and Ana Pérez-del-Olmo -- part 2. Trematodes of interest in human health. Schistosomiasis / Fred A. Lewis and Matthew S. Tucker -- Fascioliasis / Santiago Mas-Coma, M. Adela Valerno and M. Dolores Bargues -- Paragonimiasis / David Blair -- Liver flukes: Clonorchis and Opisthorchis / Weerachai Saijuntha, Paiboon Sithithaworn, Nadda Kaitsopit, Ross H. Andrews, and Trevor N. Petney -- Intestinal trematode infections / Rafael Toledo, Carla Muñoz-Antoli, and J. Guillermo Esteban -- Epidemiology of trematode infections / Jong-Yil Chai -- Diagnosis of human trematode infections / J. Guillermo Esteban, Carla Muñoz-Antoli, Rafael Toledo, and Lawrence R. Ash -- part 3. Trematodes of interest in veterinary and wildlife disease. Schistosomatoidea and Diplostomoidea / Petr Horák, Libuš Kolá̌řová, and Libor Mikeš -- Amphistomes / Veena Tandon, Bishnupada Roy, Jollin Andrea Shylla -- Dicrocoeliidae family: major species causing veterinary diseases / M. Yolanda Manga-González and M. Carmen Ferreras -- Selected wildlife trematodiasis / Jane E. Huffman -- Index.
    Also available: Print – 2014
  • 2008 ScienceDirect
    edited by Josep Font, Manuel Ramos-Casals, Juan Rodés.
    The book "The digestive system in systemic autoimmune diseases" represents the state-of-the-art in the field of digestive disorders in the most common systemic autoimmune diseases. The volume consists of an introductory chapter on imaging techniques in digestive diseases, followed by eight chapters on digestive manifestations in specific systemic autoimmune diseases. The final five chapters deal with digestive diseases with an autoimmune pathogenesis and systemic manifestations. International in scope, the table of contents reads like a Who's who in clinical research on systemic autoimmune diseases. More than 20 contributors from the European Union, the United States, Mexico and South Africa share their knowledge in this detailed volume. *One book of leading international clinical and scientific experts on autoimmune and digestive diseases. *A practical guide to the identification, diagnosis and treatment of digestive involvement in patients with autoimmune diseases that will be useful for all medical specialties. *Several diseases and conditions not included in other text books are included, some of which are of recent emergence. *Each chapter is designed to serve as a Guide to Clinical Practice for each disease.
  • 2009 Springer
    Nancy B. Finn, William F. Bria.
  • 2015
    Robert Wachter.
    Status: Not Checked OutLane Catalog Record
    For the past few decades, technology has been touted as the cure for all of healthcare's ills, yet medicine stubbornly resisted computerization-- until now. Thanks largely to billions of dollars in federal incentives, healthcare has finally gone digital. Wachter examines healthcare at the dawn of its computer age, and shows how technology is changing care at the bedside. He questions whether government intervention has been useful or destructive-- and does so with clarity, insight, humor, and compassion.
  • 2014 Atypon
    Faraz Oloumi, Rangaraj M. Rangayyan, Anna L. Ells.
    The monitoring of the effects of retinopathy on the visual system can be assisted by analyzing the vascular architecture of the retina. This book presents methods based on Gabor filters to detect blood vessels in fundus images of the retina. Forty images of the retina from the Digital Retinal Images for Vessel Extraction (DRIVE) database were used to evaluate the performance of the methods. The results demonstrate high efficiency in the detection of blood vessels with an area under the receiver operating characteristic curve of 0:96. Monitoring the openness of the major temporal arcade (MTA) could facilitate improved diagnosis and optimized treatment of retinopathy. This book presents methods for the detection and modeling of the MTA, including the generalized Hough transform to detect parabolic forms. Results obtained with 40 images of the DRIVE database, compared with hand-drawn traces of the MTA, indicate a mean distance to the closest point of about 0:24 mm. This book illustrates applications of the methods mentioned above for the analysis of the effects of proliferative diabetic retinopathy and retinopathy of prematurity on retinal vascular architecture.
  • 2011 Atypon
    Xiaolu Zhu, Rangaraj M. Rangayyan, Anna L. Ells.
    Fundus images of the retina are color images of the eye taken by specially designed digital cameras. Ophthalmologists rely on fundus images to diagnose various diseases that affect the eye, such as diabetic retinopathy and retinopathy of prematurity. A crucial preliminary step in the analysis of retinal images is the identification and localization of important anatomical structures, such as the optic nerve head (ONH), the macula, and the major vascular arcades. Identification of the ONH is an important initial step in the detection and analysis of the anatomical structures and pathological features in the retina. Different types of retinal pathology may be detected and analyzed via the application of appropriately designed techniques of digital image processing and pattern recognition. Computer-aided analysis of retinal images has the potential to facilitate quantitative and objective analysis of retinal lesions and abnormalities. Accurate identification and localization of retinal features and lesions could contribute to improved diagnosis, treatment, and management of retinopathy.
  • 2005 Springer
    Bernd Jähne.
  • 2014 Springer
    Oleg S. Pianykh.
    Making a good diagnostic image is only the beginning; keeping it good and diagnostically sound is a much more difficult proposition, one that is often neglected or forgotten by clinical practitioners. With anything digital, the assumption of persistent original quality opens a Pandora's box of medical fiascos. Poorly selected image interpolation, thoughtlessly used compression, confused image enhancement options and the like can transform a good original into a useless clutter of pixels. This book is dedicated to learning better options.
  • 2005 CRCnetBASE
    edited by Todd R. Reed.
  • 2012 Springer
    Oleg S. Pianykh.
    Part I. Introduction to DICOM -- 1. What Is DICOM? -- 2. How does DICOM work? 3. Where do you get DICOM from? -- Part II. DICOM and clinical data -- 4. A brief history of DICOM -- 5. Parlez-vous DICOM? 6. Medical images in DICOM -- Part III. DICOM comunications -- 7. DICOM SOPs: Basic 8. DICOM SOPs: Beyond basic -- 9. DICOM associations -- Part IV: DICOM media and security -- 10. DICOM media: files, folders, and DICOMDIRs -- 11. DICOM security -- 12. Incompatibility of compatible -- Part V. Advanced topics -- 13. DICOM and teleradiology -- 14. Standards and system integration in digital medicine -- 15. Disaster PACS planning and management -- 16. DICOM applications: usual and not -- 17. DICOM software development -- 18. DICOM implementation plans -- 19. DICOM FAQs.
  • 2008 Springer
    Oleg S. Pianykh.
  • 2013 Springer
    Luís Lanca, Augusto Silva.
  • 2010 Springer
    U. Bick, F. Diekmann (eds.) ; with contributions by C. Balleyguier ... [et al.] ; foreword by A.L. Baert.
  • 2008 Springer
    IWDM 2008, Tucson, AZ, USA, July 20 - 23, 2008. Elizabeth A. Krupinski (ed.)
  • 2015 Springer
    Peter Hogg, Judith Kelly, Claire Mercer, editors.
    This up-to-date, evidence-based book covers the whole range of mammography and mammography-related techniques used in practice, and also the rapid and increasingly sophisticated evolution of mammographic clinical practice and technology.A wide range of topics, from the psychological and emotional support required from the practitioner to all aspects of screening and symptomatic mammographic imaging, are discussed. Digital Mammography: A Holistic Approach is aimed at radiographers, technicians, technologists, physicists, nurses and medical practitioners worldwide, and enables the reader to gain a better understanding of techniques, equipment and anatomy.
  • 2013 Cambridge
    edited by Gary J. Whitman, Tamara Miner Haygood.
    Detectors for digital mammography -- Image acquisition -- Preparing digital mammography images for interpretation -- Image display and visualization in digital mammography -- PACS, storage, and archiving -- Interpretation of digital screening mammography -- Efficacy of digital screening mammography -- Artifacts in digital mammography -- Mobile digital mammography -- Procedures with digital mammography -- Digital breast tomosynthesis -- Breast computed tomography -- Cases -- Comparison of commercially available systems.
  • 2007 CRCnetBASE
    Krishnendu Chakrabarty, Fei Su.
  • 2007 ScienceDirect
    edited by Greenfield Sluder, David E. Wolf.
    Also available: Print – 2007
  • 2013 ScienceDirect
    edited by Greenfield Sluder and David E. Wolf.
  • 2016 Springer
    Keith J. Kaplan, Luigi K.F. Rao, editors.
    1. Introduction -- 2. History and Perspective -- 3. Digital Image Defined -- 4. Global Perspective -- 5. Design and Innovation -- 6. Technology Advances -- 7. Business Models -- 8. Use Cases -- 9. Education -- 10. Research -- 11. Workflow/LIS Interface -- 12. Infrastructure/Automation -- 13. Image Analysis -- 14. Role in Medicine -- 15. Teleconsultation -- 16. Regulatory -- 17. Standards -- 18. Other Digital Modalities: Gross Imaging, IVM, Virtopsy -- 19. Future -- 20. Open.
  • 2011
    Suchi Saria.
    The current unprecedented rate of digitization of longitudinal health data --- continuous device monitoring data, laboratory measurements, medication orders, treatment reports, reports of physician assessments --- allows visibility into patient health at increasing levels of detail. A clearer lens into this data could help improve decision making both for individual physicians on the front lines of care, and for policy makers setting national direction. However, this type of data is high-dimensional (an infant with no prior clinical history can have more than 1000 different measurements in the ICU), highly unstructured (the measurements occur irregularly, and different numbers and types of measurements are taken for different patients) and heterogeneous (from ultrasound assessments to lab tests to continuous monitor data). Furthermore, the data is often sparse, systematically not present, and the underlying system is non-stationary. Extracting the full value of the existing data requires novel approaches. In this thesis, we develop novel methods to show how longitudinal health data contained in Electronic Health Records (EHRs) can be harnessed for making novel clinical discoveries. For this, one requires access to patient outcome data --- which patient has which complications. We present a method for automated extraction of patient outcomes from EHR data; our method shows how natural languages cues from the physicians notes can be combined with clinical events that occur during a patient's length of stay in the hospital to extract significantly higher quality annotations than previous state-of-the-art systems. We develop novel methods for exploratory analysis and structure discovery in bedside monitor data. This data forms the bulk of the data collected on any patient yet, it is not utilized in any substantive way post collection. We present methods to discover recurring shape and dynamic signatures in this data. While we primarily focus on clinical time series, our methods also generalize to other continuous-valued time series data. Our analysis of the bedside monitor data led us to a novel use of this data for risk prediction in infants. Using features automatically extracted from physiologic signals collected in the first 3 hours of life, we develop Physiscore, a tool that predicts infants at risk for major complications downstream. Physiscore is both fully automated and significantly more accurate than the current standard of care. It can be used for resource optimization within a NICU, managing infant transport to a higher level of care and parental counseling. Overall, this thesis illustrates how the use of machine learning for analyzing these large scale digital patient data repositories can yield new clinical discoveries and potentially useful tools for improving patient care.
  • 2005 Wiley
    Kaluri Venkata Rangarao, Ranjan Mallik.
    Chapter 1. Processing of Signals, p. 1-20 -- Chapter 2. Revisiting the Basics, p. 21-44 -- Chapter 3. Digital Filters, p. 45-78 -- Chapter 4. Fourier Transform and Signal Spectrum, p. 79-100 -- Chapter 5. Realisation of Digital Filters, p. 101-119 -- Chapter 6. Case Studies, p. 121-128 -- Appendix. MATLAB and C Programs, p. 129-185.
  • 2005 CRCnetBASE
    B. Preetham Kumar.
  • Carolyn Handler Miller.
  • 2012 Springer
    Kanagasingam Yogesan, Leonard Goldschmidt, Jorge Cuadros, editors.
    Digital retinal imaging performed by primary care providers and nurses, followed by remote image interpretation (teleretinal imaging), is rapidly acquiring a crucial role in many parts of the world as it permits the detection of major diseases, such as diabetic retinopathy and glaucoma, in patients who would otherwise be beyond the reach of a trained ophthalmologist. In this book, experts from around the world describe how digital teleretinal screening can be set up and optimally utilized. Technical issues are discussed, and the appropriate use of screening for different diseases and in different age groups is explained. The major part of the book draws upon the clinical experience of leading practitioners in a wide range of teleretinal applications. The result is a comprehensive source of high-quality information for clinicians and other health professionals who are involved in eye care delivery, so that they can assess how teleretinal screening might be applied to their working practice.
  • 2012
    Nora Jacobson.
    Status: Not Checked OutLane Catalog Record
    In these hard times of global financial peril and growing social inequality, injuries to dignity are pervasive. "Indignity has many faces," one man told Nora Jacobson as she conducted interviews for this book. Its expressions range from rudeness, indifference, and condescension to objectification, discrimination, and exploitation. Yet dignity can also be promoted. Another man described it as "common respect," suggesting dignity's ordinariness, and the ways we can create and share it through practices like courtesy, leveling, and contribution. Dignity and Health examines the processes and structures of dignity violation and promotion, traces their consequences for individual and collective health, and uses the model developed to imagine how we might reform our systems of health and social care. With its focus on the dignity experiences of those often excluded from the mainstream--people who are poor, or homeless, or dealing with mental health problems--as well as on vulnerabilities like age or sickness or unemployment that threaten to make us all feel "less than," Dignity and Health recognizes dignity as a moral matter embedded in the choices we make every day.
  • 2012 Wiley
    edited by Arnold Schecter.
    Persistent organic pollutants : an overview / Daniele Wikoff, Lauren Fitzgerald, Linda Birnbaum Toxic equivalency factors (TEFS) for dioxin and related compounds / Michael DeVito Historic and newer persistent organic pollutants (POPS) in U.S. food / Janice Huwe -- Flame retardants : PBDES and their replacements / Thomas Webster, Heather Stapleton -- Pharmacokinetics of TCDD and related compounds / James Olson -- Immunomodulation by persistent organic pollutants / Robert Luebke [and others] -- Developmental neurotoxicity of dioxins / G. Jean Harry, Pamela J. Lein -- Epidemiological evidence on the health effects of perfluorooctanoic acid (PFOA) / Kyle Steenland, Tony Fletcher, David Savitz -- Polybrominated dibenzo-p-dioxins and dibenzofurans / Kurunthachalam Kannan, Chunyang Liao, Hyo-Bang Moon -- Epidemiological studies on cancer and exposure to dioxin and related compounds / Lennart Hardell, Mikeal Eriksson -- Reproductive and developmental epidemiology of dioxins -- Anne Sweeney [and others] -- Bisphenol A / Thaddeus Shug [and others] -- Phthalates : human exposure and related health effects / John D. Meeker, Kelly K. Ferguson -- The seveso accident / Angela Cecilia Pesatori, Pier Alberto Bertazzi -- Agent orange : long term health and environmental impact in Vietnam / Susan Hammond, Arnold Schecter -- The yusho and yucheng rice oil poisoning incidents / Yoshito Masuda, Arnold Schecter -- The Binghamtom New York electrical transformer fire incident of 1981 / Nancy Kim, Arnold Schecter -- The Yushchenko dioxin poisoning : chronology and pharmacokinetics / John Jake Ryan -- Human health risk assessment of POPS / David Szabo, Anne E. Loccisano.
  • 2008 Springer
    edited by Martino Bolognesi, Guido di Prisco, Cinzia Verde.
    Following their own brilliant careers in haeme protein research, the outstanding scientists Jonathan and Beatrice Wittenberg continue to provide inspiration to the research community in the study of oxygen-binding proteins. Their research has provided the intellectual stimulus to bring together scientists from all over the world with the common goal of developing fascinating new ideas and performing innovative experiments. This book is dedicated to Jonathana (TM)s and Beaa (TM)s lifetime careers. It further illuminates the facts and ideas which dot the paths they traced in Biochemistry and Physiology, elaborating on how these landmark achievements were made and how the haeme proteins community still refers to them. With the field of haeme protein science such a flourishing area, the contributors to this book predict Jonathan and Bea, having played such a seminal role, will continue to be key figures for quite some time to come.
  • 2006 Springer
    Uwe Lendeckel, Dirk Reinhold, Ute Bank, editors.
    Topic I. Structure and function. Peptide substrates of dipeptidyl peptidases / Inger Brandt ... [et al.] Phosphorus-containing inhibitors of proteolytic enzymes / Angel Stöckel-Maschek ... [et al.] Biochemical properties of recombinant prolyl dipeptidases DPP-IV and DPP8 / Xin Chen. Prediction of dipeptidyl peptidase (DP) 8 structure by homology modelling / Melissa R. Pitman, R. Ian Menz, and Catherine A. Abbott -- Topic II. DPIV-related enzymes. Structure and function in dipeptidyl peptidase IV and related proteins / Mark D. Gorrell ... [et al.] Expression and function of dipeptidyl peptidase IV and related enzymes in cancer / Petr Busek ... [et al.] DP8 and DP9 have extra-enzymatic roles in cell adhesion, migration, and apoptosis / Denise M.T. Yu ... [et al.] In vivo effects of a potent, selective DPPII inhibitor: UAMC00039 is a possible tool for the elucidation of the physiological function of DPPII / Marie-Berthe Maes ... [et al.] Expression of dipeptidyl peptidase IV-like enzymes in human peripheral blood mononuclear cells / Sabine Wrenger ... [et al.] Dipeptidyl peptidase 8 has post-proline dipeptidyl aminopeptidase and prolyl endopeptidase activities / Joohong Park ... [et al.] Prolyl endopeptidase cleaves the apoptosis rescue peptide humanin and exhibits and unknown post-cysteine cleavage specificity / Joachim Wolfgang Bär ... [et al.] Distribution of dipeptidyl peptidase IV-like activity enzymes in canine and porcine tissue sections by RT-PCR / Leona Wagner ... [et al.] -- Topic III. Metabolic disorders. Relative contribution of incretins to the glucose lowering effect of DP IV inhibitors in type 2 diabetes mellitus (T2DM) / Simon A. Hinke, Raymond A. Pederson, and Christopher H.S. McIntosh. Dipeptidyl peptidase IV: a molecular switch of vascular actions of neuropeptide Y / Lijun Li, Hans-Ulrich Demuth, and Zofia Zukowska -- Topic IV. Immune disorders. Dipeptidylpeptidase IV (DPIV) and alanyl-aminopeptidases (AAPs) as a new target complex for treatment of autoimmune and inflammatory diseases: proof of concept in a mouse model of colitis / Ute Bank ... [et al.] Dipeptidyl peptidases and inflammatory bowel disease / Catherine A. Abbott ... [et al.] Possible role of DP IV inhibitors in acne therapy / Anja Thielitz ... [et al.] Dipeptidyl peptidase-IV activity and/or structure homologs (DASH): contributing factors in the pathogenesis of rheumatic diseases? / Eva Balaziova ... [et al.] -- Topic V. Neuronal diseases. Dipeptidyl peptidase IV (DP IV, CD26) and aminopeptidase N (APN, CD13) as regulators of T cell function and targets of immunotherapy in CNS inflammation / Aliza Biton ... [et al.] CD26/DP IV in T cell activation and autoimmunity / Vera Preller ... [et al.] DPIV/CD26 and FAP in cancer: a tale of contradictions / Melanie L. Sulda, Catherine A. Abbott, and Martin Hildebrandt. Type-II transmembrane prolyl dipeptidases and matrix metalloproteinases in membrane vesicles of active endothelial cells / Monica Salamone ... [et al.] Extra-enzymatic roles of DPIV and FAP in cell adhesion and migration on collagen and fibronectin / Xin M. Wang ... [et al.] Role of neuropeptide Y and dipeptidyl peptidase IV in regulation of Ewing's sarcoma growth / Joanna Kitlinska ... [et al.] The role of CD26/DPP IV in preservation of early pulmonary graft function / Florian Johannes Jung ... [et al.].
    Also available: Print – 2006
  • 2011 Springer
    by Larry Winter Roeder.
    Diplomatic theory and practice -- International funding for animal protection -- International conferences and delegation management -- The media as a tool for diplomacy -- Important associations and international organizations -- Epilogue
  • 2014 Springer Protocols
    edited by Elizabeth M.J. Gillam, School of Chemistry and Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia, Janine N. Copp, Michael Smith Laboratories, University of British Columbia, Vancouver, BC, Canada, David F. Ackerley, School of Biological Sciences, Victoria University of Wellington, Wellington, New Zealand.
  • 2013
    Nicolas Tilmans.
    Directed evolution of large combinatorial chemistry libraries is an emerging approach for small-molecule discovery. To advance this field, we have developed a DNA-programmed chemistry technique that enables breeding of drug-like compounds over multiple generations. The progeny from each cycle of synthesis, selection, and amplification act as the starting point for a subsequent generation; thus the evolutionary cycle can be iterated. The linkage between genotype and phenotype is accomplished by coupling each unique compound to a DNA gene that programs its synthesis. Here we establish the behavior of our technology using a model selection for kinase substrates. We show that the platform behaves in a predictable manner and that it should be capable of identifying useful molecules from very large compound libraries. We then use the technology to discover novel biologically active small molecules by applying a purifying selection to a naive DNA-programmed library comprising 1.1 billion distinct compounds. Given the comprehensive nature of the combinatorial synthesis and the deep sampling enabled by high throughput sequencing, we can observe the simultaneous enrichment of different chemical families, increasing our chances of identifying a true hit. We have thus identified the first known non-peptidic substrate for protein kinase. This work demonstrates the feasibility to chemically probe the substrate binding sites of kinases. More broadly, we have performed the first directed evolution of a billion member combinatorial library. We anticipate that our approach will lead to the discovery of novel small-molecule affinity reagents, pharmaceutical compound leads, imaging probes and other high-value compounds. This could substantially increase global access to small-molecule reagents, and open up new areas of biological inquiry.
  • 2002 Wiley
    edited by Susanne Brakmann and Kai Johnsson.
    ch. 1. Introduction, p. 1-3 / Kai Johnsson and Susanne Brakmann, p. 1-3 -- ch. 2. Evolutionary Biotechnology - From Ideas and Concepts to Experiments and Computer Simulations / Peter Schuster, p. 5-28 -- ch. 3. Using Evolutionary Strategies to Investigate the Structure and Function of Chorismate Mutases / Donald Hilvert, Sean V. Taylor and Peter Kast, p. 29-62 -- ch. 4. Construction of Environmental Libraries for Functional Screening of Enzyme Activity / Rolf Daniel, p. 63-78 -- ch. 5. Investigation of Phage Display for the Directed Evolution of Enzymes / Patrice Soumillion and Jacques Fastrez, p. 79-110 -- ch. 6. Directed Evolution of Binding Proteins by Cell Surface Display: Analysis of the Screening Process / K. Dane Wittrup, p. 111-126 -- ch. 7. Yeast n-Hybrid Systems for Molecular Evolution / Brian T. Carter, Hening Lin and Virginia W. Cornish, p. 127-158 -- ch. 8. Advanced Screening Strategies for Biocatalyst Discovery / Andreas Schwienhorst, p. 159-175 -- ch. 9. Engineering Protein Evolution / Stefan Lutz and Stephen J. Benkovic, p. 177-213 -- ch. 10. Exploring the Diversity of Heme Enzymes through Directed Evolution / Patrick C. Cirino and Frances H. Arnold, p. 215-243 -- ch. 11. Directed Evolution as a Means to Create Enantioselective Enzymes for Use in Organic Chemistry / Manfred T. Reetz and Karl-Erich Jaeger, p. 245-279 -- ch. 12. Applied Molecular Evolution of Enzymes Involved in Synthesis and Repair of DNA / John F. Davidson, Jon Anderson, Haiwei Guo, Daniel Landis and Lawrence A. Loeb, p. 281-307 -- ch. 13. Evolutionary Generation Versus Rational Design of Restriction Endonucleases with Novel Specificity / Thomas Lanio, Albert Jeltsch and Alfred Pingoud, p. 309-327 -- ch. 14. Evolutionary Generation of Enzymes with Novel Substrate Specificities / Uwe T. Bornscheuer, p. 329-341.
  • 1979-
    Status: Not Checked OutLane Catalog Record
  • 1978-
    Assembly of Life Sciences, National Research Council.
    Status: Not Checked OutLane Catalog Record
  • 2005 CRCnetBASE
    Stefania Spada and Gary Walsh.
  • 1978
    Status: Not Checked OutLane Catalog Record
  • 1970-71.
    Status: Not Checked OutLane Catalog Record
  • 1978-
    Status: Not Checked OutLane Catalog Record
  • 1925-
  • 2006 CRCnetBASE
    edited by Barry M. McGrath, Gary Walsh.
    Applied enzymology: an overview / Nancy Shanley and Gary Walsh -- Enzyme engineering / Barry M. McGrath -- Tissue plasminogen activator-based thrombolytic agents / Gary Walsh -- Activated protein C / Brian W. Grinnell, S. Betty Yan, and William L. Macias -- Deoxyribonuclease I / Niek N. Sanders, Stefaan C. de Smedt, and Joseph Demeester -- SS-glucocerebrosidase ceredase and cerezyme / Tim Edmunds -- A-galactosidase / Debra Barngrover -- Urate oxidase / Alain Bayol ... [et al.] -- L-asparaginase review of pharmacology, drug resistance, and clinical applications / Christine Mauz-Korholz, Volker Wahn, and Dieter Korholz -- Recombinant factor VIIa / Elisabeth Erhardtsen ... [et al.] -- Factor IX (protease zymogen) / Barry M. McGrath -- The development of aldurazyme (laronidase) / Emil Kakkis -- Additional therapeutic enzymes / Shane O'Connell.
  • 1970-
    Status: Not Checked OutLane Catalog Record
  • Google Books
    Also available: Print – 1979-
  • 2009 Springer
    Malcolm MacLachlan, Leslie Swartz, editors.
  • [Mary Grace Kovar, Julie Dawson Weeks, and William F. Forbes].
    Also available: Print – 1995
  • 2007 Springer
    by Vardit Rispler-Chaim.
    Analyzes attitudes to people with various disabilities based on Muslim jurists' works (fiqh) in the Middle Ages and the modern era. This book focuses on people with disabilities and depicts the place and status that Islamic law has assigned to them, as well as how the law envisions their participation in religious, social, and communal life.
  • 2006
    Irina Metzler.
    Status: Not Checked OutLane Catalog Record
  • 1951-
    Status: Not Checked OutLane Catalog Record
  • 2013 Springer
    Paolo Capodaglio, Joel Faintuch, Antonio Liuzzi, editors.
    "Obesity is currently regarded as one of the major health challenges of the developed world. Excess body weight is an important risk factor for morbidity and mortality from cardiovascular diseases, diabetes, cancer, musculoskeletal disorders and even psychiatric problems and is estimated to cause nearly 3 million deaths per year worldwide. Obesity is not necessarily associated with comorbidities: there are indeed metabolically healthy obese individuals. Thus, we need to consider individuals presenting simple with obesity separately from those at risk of developing or who have already developed complex clinical states potentially leading to disability. Comorbidities can tip the balance of independence in patients who already have functional limitations mainly due to the excess of mass itself or who develop conditions such as diabetes, cardiovascular conditions, non-alcoholic fatty liver disease, where an abnormal metabolism of adipose tissue prevails. Morbid obesity with comorbidities leading to disability represents a real social and economic burden for National Health Systems worldwide. The presence of multiple and associated comorbidities often represents an obstacle to being admitted to hospitals for the treatment of metabolic diseases. On the other hand, clinical units with optimal standards for the treatment of pathological conditions in normal-weight patients are often structurally and technologically inadequate for the care of patients with extreme obesity. The aim of this book is to focus on the pathophysiological and rehabilitative aspects of disabling obesity, highlighting multidisciplinary rehabilitation interventions as key to counteracting the disabling aspects of complicated obesity"--Provided by publisher.
  • 2013 Springer
    David MacGarty, David Nott, editors.
    Disaster Response -- Immediate Response to Disasters -- Priorities in Post-disaster Management -- Refugee Camps -- Complex Emergencies -- Security for the Humanitarian Worker -- Global Players -- Global Development: Millennium Development Goals -- Nongovernmental Organizations and Aid -- Developing Healthcare Systems -- International Aid -- Future of Global Health -- Trauma and Surgery -- Prehospital Care -- Mass Casualty Incident -- Military Trauma -- Tropical Surgery -- Surgery in Austere Environments -- Tropical Medicine -- Polio and Vaccination Campaigns -- Malaria in Children -- Cholera: An Infectious Waterborne Disease -- HIV/AIDS -- Blinding Eye Diseases -- Public Health -- Malnutrition -- Sexual and Reproductive Health -- Maternal and Neonatal Health -- Mental Health Following Armed Conflict -- The Global Crisis in Noncommunicable Disease.
  • 2007 Ovid
    editors, David E. Hogan, Jonathan L. Burstein.
    General concepts -- Basic perspectives on disaster / David E. Hogan and Jonathan L. Burstein -- Triage / David E. Hogan and Julio Rafael Lairet -- Pediatric considerations in disasters / Mark A. Brandenburg -- Public health disasters / Eric K. Noji -- Infectious diseases and disasters / P. Gregg Greenough -- Pharmaceuticals in disasters / Robie V. Harrington -- Critical incident stress / Neill S. Oster and Constance J. Doyle -- Urban search and rescue / Carl S. Goodman and David E. Hogan -- Complex humanitarian emergencies / Frederick M. Burkle -- Disaster response planning and coordination -- Principles of hospital disaster planning / Erik Auf der Heide -- Emergency medical services in disasters / David W. Callaway -- Local government emergency disaster planning / Aden E. Hogan -- The United States national response plan / David E. Hogan and Jonathan L. Burstein -- Communication and information technology tools for disaster response and medical assistance / Victoria Garshnek and Frederick M. Burkle -- Managing disasters in austere environments / James P. McClay, Kim Moore, and David E. Hogan -- Natural disasters -- Earthquakes / Carl H. Schultz -- Tornadoes / David E. Hogan -- Hurricanes / John T. Meredith -- Floods / James Poole and David E. Hogan -- Firestorms and wildfires / Robert R. Frantz. Winter storms / Aaron Q. Lane and S. Brent Barnes -- Avalanches / Aaron Q. Lane and Jennifer Eischen -- Heat-related disasters / Glen Bailey and James S. Walker -- Volcanic eruptions / David E. Hogan and Jeremy Bearden -- Tsunamis / Kim Moore and David E. Hogan -- Industrial, technological, and transportation disasters -- Medical management of radiation incidents / Fun H. Fong, Jr. -- Hazardous materials emergencies / Howard W. Levitin and Henry J. Siegelson -- Mass gathering medical care / Steven J. Parrillo -- Maritime disasters / Jennifer Eischen -- Air crash disasters / Julio Rafael Lairet and David E. Hogan -- Fires and mass burn care / David E. Hogan, Heidi Metheney, and Michael Houston -- Conflict-related disasters -- Conventional terrorist bombings / Daniel J. Dire -- Nuclear detonations: evaluation and response / Fun H. Fong, Jr. -- Intentional chemical disasters / Mark Edward Keim and Jonathan L. Burstein -- Biological weapons agents / George W. Christopher ... [et al.] -- Tactical emergency services / David W. Callaway -- Mass shootings / Thomas M. Stein -- Education, training and research -- Education and training in disaster medicine / Ted Kellison, Timothy A. Soult, and David E. Hogan -- Research in disaster medicine / Kobi Peleg and Limor Aharonson-Daniel.
  • 2014 Springer
    edited by Charles A. Cefalu, editor.
    Disaster Preparedness for Seniors: A Comprehensive Guide for Healthcare Professionals outlines specific disaster scenarios for homebound, community, hospitalized, long term care, homeless and aged veterans. Chapters are written by a diverse group of authors, all of whom offer insight and expertise in training healthcare professionals in preparing for disasters. Topics include myths and realities of natural disasters and disaster preparedness for special populations of elders-the acute care elderly, the community-dwelling elderly, home based primary care senior veterans, the immune-compromised elderly, those with multiple and co morbid illnesses, the long-term care elderly, those elderly at the end of life and the effects of disaster on caregivers. A significant portion of the book is also devoted to training, competencies, literacy, cultural competency and resilience in disaster preparedness as well as the role of the academic medical center. The volume concludes with coverage of the management of behavioral, medical and psychological consequences of disasters. Disaster Preparedness for Seniors: A Comprehensive Guide for Healthcare Professionals is an important new volume and will serve as a guide for the development of programs, policies and procedures for evacuation of seniors during various disaster scenarios.
  • 2009 ScienceDirect
    Bruce W. Clements.
    General public health preparedness -- Bioterrorism -- Bombings and explosions -- Chemical disasters -- Earthquakes -- Floods -- Heat waves -- Hurricanes -- Nuclear and radiological disasters -- Pandemic influenza -- Thunderstorms and tornadoes -- Volcanoes -- Wildfires -- Winter storms.
  • 2015 Springer
    Allen C. Templeton, Stephen R. Byrn, Roy J. Haskell, Thomas E. Prisinzano, editors.
    This authoritative volume provides a contemporary view on the latest research in molecules with optimal drug-like properties. It is a valuable source to access current best practices as well as new research techniques and strategies. Written by leading scientists in their fields, the text consists of fourteen chapters with an underlying theme of early collaborative opportunities between pharmaceutical and discovery sciences. The book explores the practical realities of performing physical pharmaceutical and biopharmaceutical research in the context of drug discovery with short timelines and low compound availability. Chapters cover strategies and tactics to enable discovery as well as predictive approaches to establish, understand and communicate risks in early development. It also examines the detection, characterization and assessment of risks on the solid state properties of advanced discovery and early development candidates, highlighting the link between solid state properties and critical development parameters such as solubility and stability. Final chapters center on techniques to improve molecular solubilization and prevent precipitation, with particularly emphasis on linking physiochemical properties of molecules to formulation selection in preclinical and clinical settings.
  • 2006 Springer
    [edited by] Frank Eisenhaber.
    Bioinformatics: mystery, astrology, or service technology? / Frank Eisenhaber -- Reliable and specific protein function prediction by combining homology with genomic(s) context / Martijn A. Huynen, Berend Snel, and Toni Gabalden -- Clues from three-dimensional structure analysis and molecular modelling: new insights into cytochrome P450 mechanisms and functions / Karin Schleinkofer and Thomas Dandekar -- Prediction of protein function: two basic concepts and one practical recipe / Frank Eisenhaber -- Extracting information for meaningful function inference through text-mining / Hong Pan ... [et al.] -- Literature and genome data mining for prioritizing disease-associated genes / Carolina Perez-Iratxeta, Peer Bork, and Miguel A. Andrade -- Model-based inference of transcriptional regulatory mechanisms from DNA microarray data / Harmen J. Bussemaker -- The predictive power of molecular network modelling: case studies of predictions with subsequent experimental verification / Stefan Schuster, Edda Klipp, and Marko Marhl -- Theory of early molecular evolution: predictions and confirmations / Edward N. Trifonov -- Hitchhiking mapping: limitations and potential for the identification of ecologically important genes / Christian Schlötterer -- Understanding the functional importance of human single nucleotide polymorphisms / Saurabh Asthana and Shamil Sunyaev -- Correlations between quantitative measures of genome evolution, expression, and function / Yuri I. Wolf, Liran Carmel, and Eugene V. Koonin.
  • 2005 ebrary
    Daniel T. Larose.
  • 2012
    Kristen Jones Holmes.
    Whi3 is an RNA binding protein that regulates cell cycle entry by binding to mRNA of the G1 cyclin CLN3 and to the cyclin-dependent kinase Cdc28. Cln3 binds to Cdc28 to promote passage through Start. whi3[delta] cells have a small size phenotype, and Whi3 may regulate cell size by sequestering CLN3 mRNA and Cdc28 protein in the cytoplasm to delay G1 entry (Wang et al., 2004). We observe that Whi3 reversibly localizes from the cytosol to cytoplasmic puncta in response to glucose deprivation and heat shock. This phenotype is shared by components of stress granules (SGs), which are large RNP complexes that form in yeast in response to various stress conditions; SGs sort and process mRNAs during the stress response (Buchan et al., 2008). Because Whi3 shares several characteristics with known SG components, including an RNA binding domain and stress-dependent relocalization, we hypothesize that Whi3 is a novel component of SGs. We show that Whi3 colocalizes with SG markers in response to glucose deprivation and heat shock. Preventing SG formation inhibits Whi3 foci formation. Like SG components, Whi3 is enriched in insoluble cell fractions during stress. Whi3 is not required for SG formation, but may be targeted to SGs to carry out a previously unknown function. We conclude that Whi3 is a novel component of yeast stress granules. This observation suggests an alternative model for Whi3 function: that Whi3 might regulate mRNA translation during stress by transporting mRNA to stress granules. We demonstrate that Whi3 regulates many of its interacting RNAs, and that this regulation may promote stress-dependent survival.
  • 2006
    Paul Insel, R. Elaine Turner, Don Ross.
    Status: Not Checked OutLane Catalog Record
    Energy balance and weight management: finding your equilibrium -- Vitamins : vital keys to health -- Water and minerals : the ocean within -- Sports nutrition : eating for peak performance -- Life cycle : maternal and infant nutrition -- Life cycle : from childhood through adulthood -- Food safety and technology : microbial threats and genetic engineering -- World view of nutrition : the faces of global malnutrition. Food choices : nutrients and nourishment -- Nutrition guidelines : tools for a healthful diet -- Complementary nutrition: functional foods and dietary supplements -- The human body : from food to fuel -- Carbohydrates : simple sugars and complex chains -- Lipids : not just fat -- Proteins and amino acids : function follows form --
  • 2010
    Paul Insel, R. Elaine Turner, Don Ross.
    Status: Not Checked OutLane Catalog Record
    Food choices : nutrients and nourishment -- Nutrition guidelines : tools for a healthful diet -- Complementary nutrition : functional foods and dietary supplements -- The human body : from food to fuel -- Carbohydrates : simple sugars and complex chains -- Lipids : not just fat -- Proteins and amino acids : function follows form -- Energy balance and weight management : finding your equilibrium -- Vitamins : vital keys to health -- Water and minerals : the ocean within -- Sports nutrition : eating for peak performance -- Life cycle : maternal and infant nutrition -- Life cycle : from childhood through adulthood -- Food safety and technology : microbial threats and genetic engineering -- World view of nutrition : the faces of global malnutrition.
  • 2012
    Tiffany Hung.
    Recent advances in transcriptome analysis have revealed a large number of non-protein coding transcripts that have previously been uncharacterized. A subset of these molecules, termed long noncoding RNAs (lncRNAs), has been implicated in the regulation of chromatin states. Here, we detail a journey of lncRNA discovery and analysis, beginning from the de novo discovery of lncRNAs within the promoters of cell cycle genes, followed by the functional characterization of select candidates. We characterize two examples that regulate the p53-mediated DNA damage response. LncRNA PANDA blocks the apoptosis pathway by inhibiting the transcription factor NF-YA, and lncRNA DINO regulates the p53 transcriptional response by regulating SET7-mediated post-translational modification. Altogether, these studies support a model whereby pervasive lncRNA transcripts, previously discarded as transcriptional byproducts, function through diverse mechanisms as critical regulators of biological pathways.
  • 2011
    Andrew Everett Howery.
    CLC chloride channels and transporters play diverse physiological roles in processes ranging from regulating bone-density, muscle excitability, and blood pressure, to facilitating extreme-acid survival of pathogenic bacteria. Defects in CLC proteins cause human disorders in these processes. Small-molecule inhibitors of the CLCs would be useful as drugs for treating a variety of CLC-related human diseases and also to investigate CLC physiology. In addition, inhibitors are powerful tools for studying molecular mechanisms of Cl-- gating. Trapping channels or transporters in particular conformational states with high-affinity ligands could potentially advance our understanding of the structural basis for CLC activity. Despite their usefulness, specific small-molecule inhibitors for CLC proteins are scarce. To address this shortfall, we have exploited the 4,4'-diisothiocyanatostilbene-2,2'-disulfonic acid (DIDS) scaffold to develop two novel classes of CLC inhibitors. DIDS has been used as an anion-transport inhibitor for decades and was first used to inhibit CLCs over 30 years ago. However, experiments to determine the compound's mode of inhibition led us to discover that minor contaminants in the DIDS solutions inhibit CLC proteins more effectively than DIDS itself. The contaminants were found to derive from hydrolysis of the labile isothiocyanate moieties. The structures of five major hydrolysis products were determined by 1H NMR, HRMS analysis, and chemical synthesis to be DIDS-based polythioureas. These compounds bind directly to the CLC proteins, as evidenced by the fact that they inhibit purified, reconstituted ClC-ec1 and that inhibition of ClC-Ka can be prevented by the point mutation N68D. These polythioureas are the highest affinity inhibitors known for the CLCs and provide a new class of chemical probes for dissecting the molecular mechanisms of chloride transport. The second class of identified CLC inhibitors combines the DIDS core structure with alkyl chain carboxylic acids. The most potent inhibitor identified, 4,4'-octanamidostilbene-2,2'-disulfonic acid (OADS), inhibits ClC-ec1 with an apparent affinity of 29 [Mu]M. As a means to identify the inhibitor-binding site, we synthesized photo-reactive diazirine derivatives of OADS and showed that these photo-affinity reagents specifically inhibit ClC-ec1. Experiments to identify the binding site using 'top-down' mass spectrometry, in which the protein is cleaved into peptide fragments via electron-capture dissociation, have identified an intracellular binding region encompassing 76 amino acids, or 16% of the protein. Current efforts using protease digestion procedures are focused on further refinement of the binding region. Once located, protein/inhibitor interactions gleaned from the labeling of ClC-ec1 could allow us to rationally design more potent inhibitors of CLC transporters and channels.
  • 2007 Wellcome Trust
    edited by D.A. Christie and E.M. Tansey.
  • v. 1-2, 1942-49.
    por Joaquín Parada Aparicio.
    Status: Not Checked OutLane Catalog Record
  • 2014 NAP
    Committee on Strategies for Responsible Sharing of Clinical Trial Data, Board on Health Sciences Policy.
    "Discussion Framework for Clinical Trial Data Sharing: Guiding Principles, Elements, and Activities is part of a study of how data from clinical trials might best be shared. This document is designed as a framework for discussion and public comment. This framework is being released to stimulate reactions and comments from stakeholders and the public. The framework summarizes the committee's initial thoughts on guiding principles that underpin responsible sharing of clinical trial data, defines key elements of clinical trial data and data sharing, and describes a selected set of clinical trial data sharing activities."--Publisher's website.
  • 2006 NCBI Bookshelf
    editors, Dean T. Jamison, Richard G. Feachem, Malegapuru W. Makgoba ... [et al.].
    Changing patterns of disease and mortality in Sub-Saharan Africa: an overview / Florence K. Baingana and Eduard R. Bos -- Levels and trends in mortality in Sub-Saharan Africa: an overview / Jacob Adetunji and Eduard R. Bos -- Trends in child mortality, 1960 to 2000 / Kenneth Hill and Agbessi Amouzou -- Levels and trends of adult mortality / Debbie Bradshaw and Ian M. Timaeus -- Causes of death / Chalapati Rao, Alan D. Lopez, and Yusuf Hemed -- Population and mortality after AIDS / Rodolfo A. Bulatao -- Levels and patterns of mortality at INDEPTH demographic surveillance systems / Osman A. Sankoh ... [et al.] -- Trends and issues in child undernutrition / Todd Benson and Meera Shekar -- Diarrheal diseases / Cynthia Boschi-Pinto, Claudio F. Lanata, Walter Mendoza, and Demissie Habte -- Developmental disabilities / Geoff Solarsh and Karen J. Hofman -- Acute respiratory infections / Shabir A. Mahdi and Keith P. Klugman -- Vaccine-preventable diseases / Mark A. Miller and John T. Sentz -- Tuberculosis / Christopher Dye ... [et al.] -- Malaria / Robert W. Snow and Judy A. Omumbo -- Onchocerciasis / Uche Amazigo ... [et al.] -- Maternal mortality / Khama O. Rogo, John Oucho, and Philip Mwalali -- HIV/AIDS / Souleymane Mboup ... [et al.] -- Lifestyle and related risk factors for chronic diseases / Krisela Steyn and Albertino Damasceno -- Diabetes mellitus / Jean-Claude Mbanya and Kaushik Ramiaya -- Cancers / Freddy Sitas ... [et al.] -- Cardiovascular disease / Anthony Mbewu and Jean-Claude Mbanya -- Mental health and the abuse of alcohol and controlled substances / Florence K. Baingana, Atalay Alem, and Rachel Jenkins -- Neurological disorders / Donald Silberberg and Elly Katabira -- Violence and injuries / Brett Bowman ... [et al.].
  • 2006 NCBI Bookshelf
    editors, Dean T. Jamison ... [et al.].
  • 2006
    Status: Not Checked OutLane Catalog Record
    Mental disorders / Steven Hyman ... [et al.] -- Neurological disorders / Vijay Chandra ... [et al.] -- Learning and developmental disabilities / Maureen S. Durkin ... [et al.] -- Alcohol / Jürgen Rehm ... [et al.] -- Illicit opiate abuse / Wayne Hall ... [et al.].
  • 2007 Springer
    Gary A. Wobeser.
  • 2016 Springer
    Paul J. Thuluvath.
    As there is a high incidence of disease recurrence after liver transplantation, this volume is designed around the need for a reference text dealing exclusively with this problem. The book places special emphasis on pre- and post-transplant predictors of recurrence, severity assessment, prophylaxis, and treatment. Pathobiology of disease recurrence is discussed in detail where applicable. Issues including quality of life and cost burden are also covered in the text. Written by well-known authorities in each field, Disease Recurrence After Liver Transplantation: Natural History, Treatment and Survival serves as a comprehensive reference for physicians and surgeons who take care of liver transplant recipients and a major addition to the literature detailing the current understanding of disease recurrence.
  • 2006 Ovid
    Mental and emotional disorders -- Infection -- Trauma -- Neoplasms -- Immune disorders -- Hematologic disorders -- Cardiovascular disorders -- Respiratory disorders -- Neurologic disorders -- Musculoskeletal disorders -- Renal and urologic disorders -- Gastrointestinal disorders -- Metabolic disorders -- Endocrine disorders -- Obstetric and gynecologic disorders -- Eye disorders -- Ear, nose, and throat disorders -- Skin disorders.
  • v. 1-2, 1947-.
    Moncrieff, Alan; Paterson, Donald.
    Status: Not Checked OutLane Catalog Record
  • 2010 Springer
    edited by Shamim I. Ahmad.
    Triple A syndrome / Vijaya Sarathi and Nalini S. Shah -- Amyotrophic lateral sclerosis / J. Jefferson ... [et al.] -- Early onset ataxia with ocular motor apraxia and hypoalbuminemia/ataxia with oculomotor apraxia 1 / Masayoshi Tada ... [et al.] -- Clinical features and pathogenesis of Alzheimer's disease : involvement of mitochondria and mitochondrial DNA / Michelangelo Mancuso ... [et al.] -- Huntington's disease / Emmanuel Roze ... [et al.] -- Clinical features and molecular mechanisms of spinal and bulbar muscular atrophy (SBMA) / Masahisa Katsuno ... [et al.] -- Spinocerebellar ataxia with axonal neuropathy / Cheryl Walton ... [et al.] -- Tuberous sclerosis complex and DNA repair / Samy L. Habib -- Hereditary photodermatoses / Dennis H. Oh and Graciela Spivak -- Trichothiodystrophy : photosensitive, TTDP, TTD,Tay syndrome / W. Clark Lambert, Claude E. Gagna, and Muriel W. Lambert -- Cornelia De Lange syndrome / Jinglan Liu and Gareth Baynam -- Rectal cancer and importance of chemoradiation in the treatment / Sergio Huerta -- Familial cutaneous melanoma / Johan Hansson -- Primary immunodeficiency syndromes / Mary A. Slatter and Andrew R. Gennery -- Inherited defects of immunoglobulin class switch recombination / Sven Kracker, Pauline Gardøs, and Anne Durandy -- Ligase IV syndrome / Dimitry A. Chistiakov -- Muir-Torre syndrome / Pedro Mercader -- Wilms' tumor / Carlos H. Martinez, Sumit Dave, and Jonathan Izawa -- Cerebro-oculo-facio-skeletal syndrome / Hiroshi Suzumura and Osamu Arisaka -- Dyskeratosis congenita / Vineeta Gupta and Akash Kumar -- Retinoblastoma / Dietmar Lohmann -- Von Hippel Lindau syndrome / Jenny J. Kim, Brian I. Rini, and Donna E. Hansel.
    Also available: Print – 2010
  • 2009 Springer
    Jan Bruin, Leo P.S. van der Geest, editors.
  • 2011 Springer
    42nd International Diagnostic Course in Davos (IDKD), Davos, March 21-26, 2010 ; including the Nuclear Medicine Statellite Course '"Diamond", Davos, March 20-21, 2010, Pediatric Satellite Course "Kangaroo", Davos, March 20-21, 2010, IDKD in Greece ; presented by the Foundation for the Advancement of Education in Medical Radiology, Zurich ; J. Hodler, G.K. von Schulthess, C.L. Zollikofer (eds.).
    Emergency radiology of the abdomen: the acute abdomen -- Trauma of the abdomen and pelvis -- Diseases of the esophagus and stomach -- Small-bowel imaging: pitfalls in computed tomography enterography/enteroclysis -- Diseases of the small bowel, including the duodenum-MRI --Imaging of the colon and rectum: inflammatory and infectious diseases -- CT colonography: updated -- Imaging of diffuse and inflammatory liver diseases -- Focal liver lesions -- Imaging diseases of the gallbladder and bile ducts -- Diseases of the pancreas, I: pancreatitis -- Diseases of the pancreas, II: tumors -- Adrenal imaging and infection -- Renal tumors -- Urinary tract obstruction and infection -- Benign diseases of the female genital tract -- Malignant diseases of the female genital tract -- Magnetic resonance imaging of prostate cancer -- Imaging of the male pelvis: the scrotum -- Spread of metastatic disease in the abdomen and pelvis -- Abdominal vascular disease: diagnosis and therapy -- Non-vascular abdominal disease: diagnosis and therapy -- An approach to imaging the acute abdomen in the pediatric population -- Imaging uronephropathies in children -- Integrated imaging in genitourinary oncology: PET/CT imaging -- Integrated imaging in gastrointestinal oncology: PET/CT imaging -- Lymphoma: diagnostic and therapeutic applications of radiopharmaceuticals -- Conventional nuclear medicine in the evaluation of gastrointestinal and genitourinary tract disorders -- PET in hepatobiliary-pancreatic tumors -- PET in tumors of the digestive tract -- Tumors of the adrenergic system: imaging and therapy -- Neuroendocrine tumors of the abdomen: imaging and therapy -- Imaging cystic kidneys in children -- Understanding duplication anomalies of the kidney -- Malrotation: techniques, spectrum of appearances, pitfalls, and management -- Pediatric intestinal ultrasonography.
  • 2014 Springer
    presented by the Foundation for the Advancement of Education in Medical Radiology, Zurich ; J. Hodler, R.A. Kubik-Huch, G.K. von Schulthess, Ch.L. Zollikofer (eds.).
  • 2006 Springer
    38th International Diagnostic Course in Davos (IDKD), Davos, April 1-7, 2006, including the Pediatric Satellite Course "Kangaroo", Davos, April 1-2, 2006, presented by the Foundation for the Advancement of Education in Medical Radiology, Zurich ; J. Hodler, G.K. von Schulthess, Ch.L. Zollikofer (eds).
  • Google Books
    Kershaw, James Martine.
    Contents -- pt. 1. Facial neuralgia and the visceralgiae, their diagnosis and treatment.
    Also available: Print – 1878-
  • 2012 Springer
    J. Hodler, G. K. von Schulthess, Ch. L. Zollikofer (eds.).
    pt. 1. Workshops -- Brain Tumors / Edmond A. Knopp and Walter Montanera -- Mass Lesions of the Brain: A Differential Diagnostic Approach / Michael Brant-Zawadzki -- Differential Diagnosis of Brain Masses / James G. Smirniotopoulos and Steven J. Goldstein -- Evaluation of Cerebral Vessels / Robert A. Willinsky -- Evaluation of the Cerebral Vessels: Endovascular Therapy / Mary E. Jensen -- Brain Ischemia: CT and MRI Techniques in Acute Stroke / Jens Fiehler and Howard A. Rowley -- Hemorrhagic Vascular Pathologies, I / James Byrne -- Hemorrhagic Vascular Pathologies, II / Martin Wiesmann -- Demyelinating Diseases / Kelly K. Koeller and Frederik Barkhof -- Degenerative Brain Disease and Aging / Marco Essig and Mark A. van Buchem -- Neuroradiological Diagnosis of Craniocerebral Trauma: Current Concepts / Paul M. Parizel and C. Douglas Phillips -- Nontraumatic Neuroemergencies, I / Patrick A. Brouwer -- Nontraumatic Neuroemergencies, II / John R. Hesselink -- Epilepsy and Neuroimaging / Linda J. Bagley and Timo Krings -- Infectious Diseases of the Central Nervous System / Vincent Dousset and Alain Bonafé -- Cerebral Infections / David J. Mikulis -- Diseases of the Sella and Parasellar Region / Walter Kucharczyk and Charles L. Truwit -- Temporal Bone and Auditory Pathways / Jan W. Casselman and Francis Veillon -- Imaging Diseases of the Pharynx and Oral Cavity / Wendy R. K. Smoker and Bernhard Schuknecht -- Diseases of the Larynx / Martin G. Mack and Hugh D. Curtin -- Extramucosal Spaces of the Suprahyoid Neck / Laurie A. Loevner -- Sinonasal Imaging / David M. Yousem -- Degenerative Disc Disease of the Spine: Anatomic and Imaging Considerations / Michael T. Modic and Christian W. A. Pfirrmann -- Acute Spinal Trauma / Pia C. Sundgren and Adam E. Flanders -- Spinal Cord Inflammatory and Demyelinating Diseases / Majda M. Thurnher -- Spinal Inflammatory and Infectious Diseases / Jeffrey S. Ross -- Congenital and Acquired Abnormalities of the Pediatric Brain / William S. Ball and Thierry A. G. M. Huisman -- Imaging of Pediatric Brain and Spinal Cord Tumors / Tina Young Poussaint and Andrea Rossi -- pt. 2. Nuclear Medicine Satellite Course Diamond -- Imaging Alzheimer in 2011 / Marieke Hazewinkel and Frederik Barkhof -- Quantification of NeuroPET: When to Use It / Alfred Buck -- Radioiodine Therapy: Current Imaging Concepts Introduction / Luca Giovanella -- Nuclear Medicine Imaging of Brain Tumors / Ian Law -- Nuclear Imaging of Neurovascular Disease / Ian Law -- Integrated PET-CT and PET-MR: Pitfalls and Applications in Head and Neck Squamous Cell Carcinoma / Laurie A. Loevner -- PET Imaging of Dementia / Osama Sabri, Solveig Tiepolt, Swen Hesse and Henryk Barthel -- Clinical SPECT and PET for Management of Patients with Refractory Epilepsy / Koen Van Laere, Karolien Goffin and Wim Van Paesschen -- pt. 3. Pediatric Satellite Course Kangaroo -- Hemorrhage, Stroke, and Ischemia of the Neonatal Brain / Maria I. Argyropoulou -- Accidental and Nonaccidental Injury of the Pediatric Brain and Spine / Thierry A. G. M. Huisman -- Acquired Infectious and Autoimmune Diseases of the Pediatric Central Nervous System / Andrea Rossi -- Imaging of the Phakomatoses in Children / Tina Young Poussaint -- pt. 4. Breast Imaging Satellite Course -- MRI of the Breast: Technique, Indications, and BI-RADS Classification / Karen Kinkel -- Microcalcifications of the Breast: An Approach to Radiologic Classification / Markus Müller-Schimpfle -- Ultrasound of the Breast, Including Interventions: An Update / Alexander Mundinger -- Mammography: Diagnosis of Asymmetries, Masses and Architectural Distortion / Christian Weismann.
  • 2008 Springer
    40th International Diagnostic Course in Davos (IDKD), Davos, March 30-April 4, 2008, including the Nuclear Medicine Satellite Course "Diamond," Davos, March 28-30, 2008, Pediatric Satellite Course "Kangaroo," Davos, March 29-30, 2008, presented by the Foundation for the Advancement of Education in Medical Radiology, Zurich ; J. Hodler, G.K. von Schulthess, Ch.L. Zollikofer (eds).
  • 2016 Springer
    48th International Diagnostic Course in Davos (IDKD), Davos, April 3-8, 2016 ; including the Nuclear Medicine Satellite Course "Diamond" Davos, April 2-3, 2016, Pediatric Radiology Satellite Course "Kangaroo" Davos, April 2, 2016, Brest Imaging Satellite Course "Pearl" Davos, April 2, 2016, and additional IDKD Courses 2016-2019 ; presented by the Foundation for the Advancement of Education in Medical Radiology, Zurich ; Jürg Hodler, Rahel A. Kubik-Huch, Gustav K von Schulthess, editors.
    This book deals with neuroimaging of the brain, head, neck, and spine. During the last few years, there have been considerable advances in this subject, driven by clinical as well as technological developments. The authors, internationally renowned experts in their field, have contributed chapters that are disease-oriented and cover all relevant imaging modalities, including magnetic resonance imaging, computed tomography, and positron emission tomography. As a result, this book offers a comprehensive review of the state of the art in neuroimaging. It is particularly relevant for general radiologists, radiology residents, neurologists, neurosurgeons, and other clinicians wishing to update their knowledge in this discipline.
  • 2014 Ovid
    edited by Jay R. Harris, Marc E. Lippman, Monica Morrow, C. Kent Osborne.
    SECTION I BREAST ANATOMY AND DEVELOPMENT -- ch. 1 Breast Anatomy and Development / Susan K. Boolbol -- ch. 2 Stem Cells in Breast Development and Carcinogenesis: Concepts and Clinical Perspectives / Max S. Wicha -- SECTION II DIAGNOSIS AND MANAGEMENT OF BENIGN BREAST DISEASE -- ch. 3 Physical Examination of the Breast / Monica Morrow -- ch. 4 Management of the Palpable Breast Mass / Richard J. Bleicher -- ch. 5 Management of Disorders of the Ductal System and Infections / Nigel J. Bundred -- ch. 6 Management of Breast Pain / Robert E. Mansel -- ch. 7 Abnormalities of the Breast in Pregnancy and Lactation / Holly S. Mason -- ch. 8 Management of Gynecomastia / Glenn D. Braunstein -- ch. 9 Pathology of Benign Breast Disorders / Stuart J. Schnitt -- SECTION III BREAST IMAGING AND IMAGE-GUIDED BIOPSY TECHNIQUES -- ch. 10 Breast Cancer Screening / Joann G. Elmore -- ch. 11 Imaging Analysis: Mammography / Stephanie K. Patterson -- ch. 12 Imaging Analysis: Ultrasonography / Emily L. Sedgwick -- ch. 13 Imaging Analysis: Magnetic Resonance Imaging / Susan Orel Roth -- ch. 14 New Breast Imaging Techniques / Maxine S. Jochelson -- ch. 15 Image-Guided Biopsy of Nonpalpable Breast Lesions / Christopher E. Comstock -- SECTION IV EPIDEMIOLOGY AND ASSESSING AND MANAGING RISK -- ch. 16 Inherited Genetic Factors and Breast Cancer / Alan Ashworth -- ch. 17 Genetic Testing and Management of Patients with Hereditary Breast Cancer / Claudine Isaacs -- ch. 18 Nongenetic Factors in the Causation of Breast Cancer / Graham A. Colditz -- ch. 19 Management of Other High Risk Patients / Seema A. Khan -- ch. 20 Chemoprevention / Powel H. Brown -- SECTION V IN SITU CARCINOMA -- ch. 21 Ductal Carcinoma In Situ and Other Intraductal Lesions: Pathology, Immunohistochemistry, and Molecular Alterations / Edi Brogi -- ch. 22 Lobular Carcinoma In Situ: Biology and Management / Jorge S. Reis-Filho -- ch. 23 Ductal Carcinoma In Situ and Microinvasive Carcinoma / Jay R. Harris -- SECTION VI PATHOLOGY AND BIOLOGICAL MARKERS OF INVASIVE BREAST CANCER -- ch. 24 Genomic Events in Breast Cancer Progression / Matthew J. Ellis -- ch. 25 Pathology of Invasive Breast Cancer / Stuart J. Schnitt -- ch. 26 Estrogen and Progesterone Receptor Testing for Prognosis and Prediction / William Miller -- ch. 27 HER2/ERBB2 Testing: Assessment of Status for Targeted Therapies / Yanling Ma -- ch. 28 Clinical and Pathologic Prognostic and Predictive Factors 6 / Frederick L. Moffat -- ch. 29 Genomics, Prognosis, and Therapeutic Interventions / Charles M. Perou -- ch. 30 Bone Marrow Micrometastases and Circulating Tumor Cells / Daniel F. Hayes -- SECTION VII MANAGEMENT OF PRIMARY INVASIVE BREAST CANCER -- ch. 31 Evaluation of Patients for Metastasis Prior to Primary Therapy / C. Kent Osborne -- ch. 32 Staging of Breast Cancer / Jay R. Harris -- ch. 33 Mastectomy / Mehra Golshan -- ch. 34 Contralateral Prophylactic Mastectomy / Todd M. Tuttle -- ch. 35 Breast-Conserving Therapy / Monica Morrow -- ch. 36 Breast Reconstruction / Alice Y. Ho -- ch. 37 Sentinel Lymph Node Biopsy / Armando E. Giuliano -- ch. 38 Axillary Dissection / George Plitas -- ch. 39 Preserving and Restoring Function after Local Treatment / Andrea L. Cheville -- ch. 40 Lymphedema / Sarah A. Mclaughlin -- ch. 41 Local Management of the Axilla / Jay R. Harris -- ch. 42 Postmastectomy Radiation Therapy / Bruce G. Haffty -- ch. 43 Adjuvant Systemic Therapy: Endocrine Therapy / C. Kent Osborne -- ch. 44 Adjuvant Systemic Chemotherapy in Early Breast Cancer / Clifford A. Hudis -- ch. 45 Adjuvant Chemo Endocrine Therapy / Nancy E. Davidson -- ch. 46 Adjuvant and Preoperative Systemic Therapy for HER2-Positive Breast Cancer / Eric P. Winer -- ch. 47 Adjuvant Systemic Therapy: Bone-Targeted Treatments / Robert E. Coleman -- ch. 48 Pharmacogenomics of Systemic Therapy / James M. Rae -- ch. 49 Implications of Obesity in Breast Cancer / Andrew J. Dannenberg -- ch. 50 Lifestyle Issues in Breast Cancer Survivors / Rowan T. Chlebowski -- ch. 51 Management of Menopausal Symptoms in Breast Cancer Survivors / Charles L. Loprinzi -- ch. 52 Long-Term and Late Effects of Primary Curative Intent Therapy: Neurocognitive, Cardiac, and Secondary Malignancies / Patricia A. Ganz -- ch. 53 Adjuvant Systemic Therapy Treatment Guidelines / C. Kent Osborne -- SECTION VIII PREOPERATIVE SYSTEMIC THERAPY -- ch. 54 Preoperative Chemotherapy for Operable Breast Cancer / Jose Baselga -- ch. 55 Preoperative Endocrine Therapy for Operable Breast Cancer / Ian E. Smith -- ch. 56 Pathologic Assessment of Treatment Response after Neoadjuvant Therapy / Susan Carole Lester -- ch. 57 Local-Regional Therapy following Systemic Treatment / Kelly K. Hunt -- ch. 58 Locally Advanced Breast Cancer / Eric A. Strom -- ch. 59 Inflammatory Breast Cancer / Lori J. Pierce -- ch. 60 Preoperative Systemic Therapy for Breast Cancer / Marc E. Lippman -- SECTION IX SPECIAL THERAPEUTIC PROBLEMS -- ch. 61 Male Breast Cancer / William J. Gradishar -- ch. 62 Phyllodes Tumors / Benjamin O. Anderson -- ch. 63 Paget's Disease / Nora M. Hansen -- ch. 64 Nonepithelial Malignancies of the Breast / Carolina Gutierrez -- ch. 65 Breast Cancer during Pregnancy and Subsequent Pregnancy in Breast Cancer Survivors / Richard L. Theriault -- ch. 66 Occult Primary Cancer with Axillary Metastases / Youlia M. Kirova -- SECTION X EVALUATION AFTER PRIMARY THERAPY AND MANAGEMENT OF RECURRENT BREAST CANCER -- ch. 67 Surveillance of Patients following Primary Therapy / Robert W. Carlson -- ch. 68 Surgery for the Primary in Patients with Distant Metastases / Tari A. King -- ch. 69 Management of Local Regional Recurrences after Primary Breast Cancer Treatment / Erica L. Mayer -- ch. 70 Treatment of Metastatic Breast Cancer: Endocrine / Gaia Schiavon -- ch. 71 Treatment of Metastatic Breast Cancer: Chemotherapy / Antonio C. Wolff -- ch. 72 Treatment of HER2-overexpressing Metastatic Breast Cancer / Mark D. Pegram -- ch. 73 Palliative Care in Breast Cancer / Thomas J. Smith -- ch. 74 Management Summary for the Care of Patients with Metastatic Breast Cancer / Marc E. Lippman -- SECTION XI NEW BREAST CANCER THERAPEUTIC APPROACHES -- ch. 75 Newer Targeted Therapy / Carlos L. Arteaga -- SECTION XII SITE-SPECIFIC THERAPY OF METASTATIC BREAST CANCER -- ch. 76 Brain Metastases / Ian F. Dunn -- ch. 77 Metastatic Epidural Spinal Cord Compression / Patrick Y. Wen -- ch. 78 Leptomeningeal Metastasis / Lisa M. Deangelis -- ch. 79 Brachial Plexopathy in Patients with Breast Cancer / Pauline T. Truong -- ch. 80 Ophthalmic Metastases / David H. Abramson -- ch. 81 Management of Isolated Liver Metastases / Steven Come -- ch. 82 Medical Treatment for Bone Metastases / Christy A. Russell -- ch. 83 Local Management of Bone Metastases / James A. Hayman -- SECTION XIII BREAST CANCER IN SPECIAL POPULATIONS -- ch. 84 Breast Cancer in Older Women / Hyman B. Muss -- ch. 85 Breast Cancer in Younger Women / Richard D. Gelber -- ch. 86 Breast Cancer in Minority Women / Lisa A. Carey -- SECTION XIV ISSUES IN BREAST CANCER SURVIVORSHIP -- ch. 87 Nursing Care in Patient Management and Quality of Life / Deborah K. Walker -- ch. 88 Overview of Survivorship Issues / Larissa Nekhlyudov -- ch. 89 Psychosocial Adaptation during and after Breast Cancer / Mary Jane Massie -- ch. 90 Reproductive Issues in Breast Cancer Survivors / Elizabeth S. Ginsburg -- ch. 91 Cost and Cost Effectiveness Considerations / Bruce E. Hillner
  • 2010 Ovid
    edited by Jay R. Harris, Marc E. Lippman, Monica Morrow, C. Kent Osborne.
    Breast anatomy and development -- Molecular mechanisms regulating breast development -- Stem cells in breast development and carcinogenesis: concepts and clinical perspectives -- Physical examination of the breast -- Management of the palpable breast mass -- Management of disorders of the ductal system and infections -- Management of breast pain -- Abnormalities of the breast in pregnancy and lactation -- Management of gynecomastia -- Pathology of benign breast disorders -- Screening for breast cancer -- Imaging analysis: mammography -- Breast ultrasound -- Imaging analysis: magnetic resonance imaging -- Imaging: new techniques -- Image-guided biopsy of nonpalpable breast lesions -- Management summary on breast imaging -- Inherited genetic factors and breast cancer -- Genetic testing and management of patients with hereditary breast cancer -- Nongenetic factors in the causation of breast cancer -- Management of other high risk patients -- Chemoprevention: clinical aspects -- Pathology and biological features of premalignant breast disease -- Lobular carcinoma in situ: biology and pathology -- Lobular carcinoma in situ: clinical management -- Ductal carcinoma in situ and microinvasive carcinoma -- Breast cancer genomics -- Pathology of invasive breast cancer -- Clinical aspects of estrogen and progesterone receptors -- ERBB2 testing: assessment of status for targeted therapies -- Prognostic and predictive markers -- Gene arrays, prognosis, and therapeutic interventions -- Bone marrow micrometastases and circulating tumor cells -- Evaluation of patients for metastasis prior to primary therapy -- Staging of breast cancer -- Mastectomy -- Breast-conserving therapy: conventional whole breast irradiation -- Breast-conserving therapy: accelerated partial breast irradiation -- Breast reconstruction -- Local therapy for the breast and chest wall -- Sentinel lymph node dissection -- Axillary dissection -- Axillary irradiation -- Preserving and restoring function after local treatment -- Lymphedema -- Treatment of the axilla and other regional nodes -- Postmastectomy radiation therapy -- Adjuvant systemic therapy: endocrine therapy -- Adjuvant systemic therapy: chemotherapy -- Adjuvant systemic therapy: chemoendocrine -- Adjuvant treatment of ERBB2 positive breast cancer -- Adjuvant systemic therapy: bisphosphonates -- Lifestyle issues in breast cancer survivors -- Management of menopausal symptoms in breast cancer survivors -- Side effects of systemic therapy: neurocognitive, cardiac, and secondary malignancies -- Pharmacogenomics of systemic therapy of breast cancer -- Guidelines for adjuvant systemic therapy -- Preoperative therapy for operable breast cancer -- Preoperative endocrine therapy for operable breast cancer -- Local-regional therapy considerations in patients receiving preoperative chemotherapy -- Locally advanced breast cancer -- Inflammatory breast cancer -- Management summary on preoperative systemic therapy -- Male breast cancer -- Phyllodes tumors -- Paget's disease -- Nonepithelial malignancies of the breast -- Breast cancer during pregnancy and subsequent pregnancy in breast cancer survivors -- Occult primary cancer with axillary metastases -- Surveillance of patients following primary therapy -- Surgery for the primary in patients with distant metastases -- Local-regional recurrence after breast-conservation treatment or mastectomy -- Treatment of metastatic breast cancer: endocrine therapy -- Treatment of metastatic breast cancer: chemotherapy -- Treatment of HER2-overexpressing metastatic breast cancer -- End-of-life considerations in patients with breast cancer -- Management summary for metastatic disease for the care of patients with metastatic disease -- Angiogenesis inhibition in breast cancer -- Tyrosine kinase inhibitors -- Newer targeted therapy in breast cancer -- Brain metastases -- Epidural metastases -- Leptomeningeal metastasis -- Brachial plexopathy in patients with breast cancer -- Ocular metastases -- Malignant effusions -- Management of discrete pulmonary nodules -- Management of lsolated liver metastases -- Bone-directed therapy and breast cancer: bisphosphonates, monoclonal anitbody, and radionuclides -- Local management of bone metastases -- Breast cancer in older women -- Breast cancer in younger women -- Breast cancer in minority women -- Nursing care in patient management and quality of life -- Psychosocial adaptation during and after breast cancer -- Reproductive issues in breast cancer survivors -- Medical legal aspects of breast cancer evaluation -- Cost and cost-effectiveness considerations.
  • 2016 Springer
    Atul C. Mehta, Prasoon Jain, Thomas R. Gildea, editors.
    This book explores the non-interventional aspects of interventional pulmonology, focusing on diseases of the central airways. As the field of bronchology and interventional pulmonology expands, newer conditions involving the central airways are being recognized with increasing frequency. Current literature has mainly focused on technical aspects of the subspecialty, but this book illuminates what else interventional pulmonology has to offer the pulmonologist, including diagnosis and alternate therapeutic options. Diseases of the Central Airways: A Clinical Guide presents techniques for the diagnoses, management and treatment of patients with intriguing central airway conditions such as: black bronchoscopy, tracheobronchomalacia, endobronchial tuberculosis, and tracheobronchopathia osteochondroplastica. In-depth chapters are written by international experts and are up-to-date and comprehensive reviews. This important new book will contribute significantly to the welfare of patients with lung ailments of the central airways.
  • 2015 Springer
    J. Hodler, R. A. Kubik-Huch, G. K. von Schulthess, Ch. L. Zollikofer (eds.).
  • 2007 Springer
    39th International Diagnostic Course in Davos (IDKD), Davos, March 25-30, 2007, including the Pediatric Satellite Course "Kangaroo", Davos, March 24-25, 2007, presented by the Foundation for the Advancement of Education in Medical Radiology, Zurich ; J. Hodler, G.K. von Schulthess, Ch.L. Zollikofer (eds).
  • 2011 Springer
    presented by the Foundation of [i.e. for] the Advancement of Education in Medical Radiology, Zurich ; J. Hodler, G.K. von Schulthess, Ch. L. Zollikofer, (eds.).
  • 2010 Springer
    Masoud Motasaddi Zarandy, John Rutka.
    Temporal Bone Tumors and Metastatic Disease -- Cholesteatoma and Its Complications -- Anomalies of the Inner Ear -- Sudden Sensorineural Hearing Loss -- Trauma to the Inner Ear -- Otosclerosis -- Presbycusis -- Ménière's Syndrome -- Benign Positional Vertigo -- Meningioma -- Vestibular Schwannoma -- Other Cranial Nerve Schwannomas and Paragangliomas -- Ototoxicity.
  • 2007 Ovid
    edited by Robert W. Schrier.
    Also available: Print – v. 1-3., 2007
  • 2014 Springer
    K.F. Murray, S. Horslen (eds.).
    Diseases of the Liver in Children: Evaluation and Management provides a comprehensive, state-of-the art review of pediatric liver disease, with a practical approach useful for the primary care provider or general gastroenterologist. With an emphasis on tables and images, this book serves as a reference for understanding basic hepatic processes and the significance of laboratory findings. It also discusses the state of the art of diagnosis and treatment of diseases that affect the pediatric liver. The text captures the key elements of treatment and monitoring important for the primary care provider partnering in the care of these patients with pediatric hepatologists. The current state of transplantation and other surgical approaches are also discussed. The importance of aggressive bowel rehabilitation in the prevention of end-stage total parenteral nutrition-induced liver disease is also covered. Written by experts in their fields and including the most up to date clinical information, Diseases of the Liver in Children: Evaluation and Management serves as a very useful resource for physicians.
  • 2008 Springer
    editors, Hans G. Beger, Seiki Matsuno, and John L. Cameron.
  • 2012 Springer
    Angelo A. Licata, Edgar V. Lerma, editors.
    1. Molecular Mechanisms of Parathyroid Hormone Synthesis / Tally Naveh-Many and Morris Nechama -- 2. Regulation of Calcium and Phosphate Metabolism / Arthur D. Conigrave -- 3. Diagnosis and Treatment of the Patient with Abnormal Calcium / Elizabeth H. Holt -- 4. The Calcium-Sensing Receptor: Physiology and Pathophysiology / Friedhelm Raue and Christine Haag -- 5. New Concepts for Primary and Secondary Hyperparathyroidism / Joachim Beige and Peter Lamesch -- 6. Calcific Uremic Arteriolopathy (Calciphylaxis) / Earl H. Rudolph and Edgar V. Lerma -- 7. Cystic Parathyroid Lesions / Jean-François Henry and Maurizio Iacobone -- 8. Parathyroid Cancer / Maurizio Iacobone and Jean-François Henry -- 9. Biochemistry, Physiology, and Pathophysiology of Parathyroid Hormone-Related Peptide / Bandana Chakravarti, Shailendra K. Dhar Dwivedi, Ambrish Mithal and Naibedya Chattopadhyay -- 10. Ectopic Parathyroid Glands / Jean-François Henry and Maurizio Iacobone -- 11. Hyperparathyroidism in Multiple Endocrine Neoplasia / Syeda S. Zaidi, Vipul T. Lakhani and James T. Broome -- 12. Familial Hypocalciuric Hypercalcemia / Ogo I. Egbuna and Edward M. Brown -- 13. Hyperparathyroidism-Jaw Tumor Syndrome / Andrew C. Calabria and Michael A. Levine -- 14. Hypoparathyroidism and Pseudohypoparathyroidism / Rajesh V. Thakker -- 15. Primary Hyperparathyroidism in Neonates and Children / Eric Mallet and Mireille Castanet -- 16. Hypoparathyroidism in Children / Anne Lienhardt-Roussie and Agnès Linglart -- 17. Parathormone Resistance in Children / Agnès Linglart and Eric Mallet -- 18. The Use of Ultrasonography in the Management of Parathyroid Diseases / Zvonimir L. Milas and Mira Milas -- 19. Imaging in Parathyroid Diseases / Donald R. Neumann and Joyce J. Shin -- 20. Parathyroid Surgery / Zvonimir L. Milas and Mira Milas.
  • 2014 Springer
    C.C. Chang, G.A. Incaudo, M.E. Gershwin, editors.
    Diseases of the Sinuses: A Comprehensive Textbook of Diagnosis and Treatment, 2nd Edition, offers the definitive source of information about the basic science of the sinuses and the clinical approach to sinusitis. Since the widely praised publication of the first edition, understanding of sinus disease has changed dramatically, mainly as a result of recent developments and new discoveries in the field of immunology. This updated and expanded edition is divided into sections addressing, separately, the pathogenesis, clinical presentation, medical and surgical management of acute and chronic rhinosinusitis. Special entities such as autoimmune-related sinusitis, allergy and sinusitis, and aspirin-exacerbated respiratory disease are discussed in separate chapters. The role of immunodeficiency is also addressed. The management section has been fully updated to incorporate new medical modalities and surgical procedures. Developed by a distinguished group of international experts who share their expertise and insights from years of collective experience in treating sinus diseases, the book will appeal to anyone who has an interest in sinus disease, including both physicians and allied health professionals. Internists, pediatricians, allergists, otolaryngologists and infectious disease specialists will find the book to be an invaluable, comprehensive reference. Physician assistants and nurse practitioners who work with specialists who treat sinus disease will also benefit from the book.
  • 2006
    Gary M. White, Neil H. Cox.
    Status: Not Checked OutLane Catalog Record
  • 2015 Springer
    Elke Hattingen, Stefan Weidauer, Matthias Setzer, Johannes C. Klein, Frank Vrionis, editors.
    Spinal cord imaging has significantly benefited from new MR imaging methods such as cardiac-gated diffusion-weighted imaging, diffusion tensor imaging with fiber tracking, and time-resolved MR angiography. Recent decades have also witnessed fundamental progress in understanding of the pathophysiology of vascular, metabolic, and inflammatory spinal cord diseases. Furthermore, neurosurgical procedures and endovascular treatments of spinal cord diseases have been improved and perfected to avoid severe neurological sequelae. This textbook provides an interdisciplinary overview of the new imaging modalities, identifies clues for MR imaging diagnosis and differential diagnosis, and describes the anatomical background required to understand spinal cord diseases. Important neurological symptoms are highlighted, and modern treatment options for different diseases are fully explained and discussed. High-quality illustrations, including numerous images, are provided for all important spinal cord diseases, documenting relevant anatomical details, special MR imaging methods, differential diagnoses, and possible treatment procedures.
  • 2007 Karger
    volume editors, Gerasimos E. Krassas, Scott A. Rivkees, Wieland Kiess.
    Ontogenesis and anatomy of the hypothalamic-pituitary-thyroid axis / Tsoumalis, G.; Tsatsoulis, A -- Thyroid disease during pregnancy / Lazarus, J.H -- Thyroid function in the newborn and infant / Spiliotis, B.E. -- Pediatric aspects of thyroid function and iodine / Knobel, M., Medeiros-Neto, G -- Thyroid hormone transport and actions / Feldt-Rasmussen, U., Rasmussen, Å.K. -- The thyroid and autoimmunity in children and adolescents / Weetman, A.P. -- Congenital hypothyroidism / Karges, B., Kiess, W. -- Newborn screening, hypothyroidism in infants, children and adolescents / Büyükgebiz, A. -- Resistance to thyroid hormone in childhood / Bakker, O. -- Pendred syndrome / Kassem, S., Glaser, B. -- Treatment of hyperthyroidism due to Graves' disease in children / Rivkees, S.A. -- Thyroid-associated ophthalmopathy in juvenile Graves' disease: clinical, endocrine and therapeutic aspects / Krassas, G.E., Gogakos, A. -- Differentiated thyroid carcinoma in pediatric age / Wiersinga, W.M. -- Imaging of the normal and affected thyroid in childhood / Bennedbæk, F.N., Hegedüs, L. -- Thyroid and other autoimmune diseases with emphasis on type 1 diabetes mellitus and Turner syndrome / Kapellen, T. ...[et al.] -- Thyroid and trace elements in children and adolescence / Kahaly, G.J.
  • 2014 Springer
    edited by Aniz Girach, Marc D. Smet.
    Disease of the vitreo-macular interface is characterized by vitreo-macular adhesion (VMA), which can lead to abnormal forces on the retina termed vitreo-macular traction (VMT). This combination of VMA and VMT can itself cause impairment of vision and is implicated in a variety of disorders, including wet age-related macular degeneration, diabetic retinopathy, macular edema, and macular hole. Vitreo-macular interface disease has recently begun to receive more attention owing in part to the advent of new imaging techniques that allow more accurate diagnosis and in part to advances in treatment. This clinically oriented book is the first to be devoted wholly to the diagnosis and treatment of vitreo-macular interface disease. World-renowned experts in the field discuss epidemiologic, anatomic, and physiologic aspects, document the findings obtained with newer imaging techniques, such as spectral domain optical coherence tomography, describe the treatment options, and report on the results of preclinical and clinical trials, including some previously unpublished findings. This book will prove invaluable for ophthalmologists as we advance toward a future in which treatments of diseases such as age-related macular degeneration and diabetic retinopathy will likely require adjunctive therapy to tackle VMA/VMT concurrently.
  • Google Books
    Galabin, Alfred Lewis; Galabin, Alfred Lewis; Galabin, Alfred Lewis.
    Also available: Print – 1884.
  • 2007 CRCnetBASE
    edited by Gurusamy Manivannan.
    Perspectives on infection challenges and solutions / Manivannan -- Sisyphus in the microbial world revisited : global governance, antimicrobial strategies, and humanity's health / Fidler -- The need for safer and better microbiocides for infection control / Sattar, Springthorpe -- Microbiological concerns in non-sterile manufacturing / Farrington, Polarine -- New technologies in disinfection and infection control / Ramirez -- Biocides : modes of action and mechanisms of resistance / McDonnell -- A pragmatic approach to judicious selection and proper use of disinfectant and antiseptic agents in healthcare setting / Suljagic -- Extended activity of healthcare antiseptic products / Newman, Kaiser -- Disinfectant rotation in a cleaning/disinfection program for cleanrooms and controlled environments / Sutton -- Reprocessing flexible endoscopes : origin of standards, overview of structure/function, and review of recent outbreaks / Antonucci, Williams, Robinson -- Microbiological testing of disinfectants and decontaminants for critical surfaces / Klein -- Regulatory constraints on disinfectants and decontamination / Sarli -- Biofilms : a summarized account and control strategies / Nandakumar, Sreekumari -- Consequences of biofilms on indwelling medical devices : costs and prevention / Thomas, Nakaishi, Corum -- Infection-resistant implantable devices : biofilm problems and design strategies / Smith, Perera -- Infections of intracardiac devices / Yesenosky ... [et al.] -- Intrauterine devices : infections and biofilms / Pereira, Pruthi -- Antimicrobial urinary catheters / Stickler, Sabbuba -- Risk factors for post-operative infectious complications after abdominal surgery / Pessaux, Lermite.
  • 2007 Karger
    volume editors, Claudio Ronco, Gary J. Mishkin.
    Antisepsis / Bianchi, P; Buoncristiani, E.; Buoncristiani, U. (Perugia) -- Sodium hypochlorite: history, properties, electrochemical production / Ponzano, G.P (Genova) -- Toxicity and safety of topical sodium hypochlorite / Bruch, M.K. (Hamilton, Va.) -- Disinfection of the dialysis monitors / Ghezzi, P.M. (Montemassi); Bonello, M. (Anagni); Ronco, C. (Vicenza) -- Biofilm on artificial surfaces / Cappelli, G. ... [et al.] -- Compatibility of electrolytically produced sodium hypochlorite solutions on long-term implanted dialysis catheters / Mishkin, G.J. (Gaithersburg, Md.) -- Hemodialysis catheter exit site care / Astle, C.M. (Edmonton) -- Effectiveness of sodium hypochlorite in the prevention of catheter related infections / Cruz, D.N. ... [et al.] -- Use of sodium hypochlorite in peritoneal dialysis : the genesis of the 'Y' set and beyond / Buoncristiani, U.; Buoncristiani, E.; Bianchi, P. (Perugia) -- Exit-site care in peritoneal dialysis / Wadhwa, N.K.; Reddy, G.H. (Stony Brook, N.Y.) -- Successful use of sodium hypochlorite pack plus systemic and local antibiotic therapy for the treatment of pseudomonas infection of peritoneal dialysis catheter exit-site / Rodighiero, M.P. ... [et al.] -- Disinfection of lines and transfer sets in peritoneal dialysis / Lew, S.Q.; Gruia, A. (Washington, D.C.) -- Amuchina 10% solution, safe antiseptic for preventing infections of exit-site of tenckhoff catheters, in the pediatric population of a dialysis program / Mendoza-Guevara, L. ... [et al.] -- Risk of peritonitis among disadvantaged CAPD patients in Mexico / Garcia-Garcia, G. ... [et al.].
    Also available: Print – 2007
  • 2014 Wiley
    edited by Nestor Cohenca.
    Root canal infection and endodontic periradicular disease / Nestor Cohenca and Ana Maria Gonzalez -- Biofilms in root canal infection / Christine M. Sedgley and Rogrio de Castilho Jacinto -- Efficacy of root canal disinfection / Ashraf F. Fouad -- Impact of root canal disinfection on treatment outcome / James Johnson and Natasha Flake -- The anatomy of the root canal system as a challenge to effective disinfection / Eric herbranson -- Shaping the root canal system to promote effective disinfection / Ove Peters and Frank Paqu -- Update on endodontic irrigating solutions / Bettina Basrani and Markus Haapasalo -- Fluid dynamics of irrigation within the root canal system / G. John Schoeffel and Franklin R. Tay -- Positive pressure irrigation / Cesar de Gregorio, Carlos Heilborn, and Nestor Cohenca -- Apical negative pressure irrigation (ANP) / Nestor Cohenca, Cesar de Gregorio and Avina Paranjpe -- Disinfection of the root canal by sonic, ultrasonic and laser activated irrigation / Luc van der Sluis, Bram Verhaagen, Ricardo Macedo, and Michel Versluis -- Ozonization and electrochemical root canal disinfection / Roberta Pileggi -- Intracanal medication in root canal disinfection / Lea Assed Bezerra da Silva, Raquel Assed Bezerra da Silva, Paulo Nelson-Filho and Nestor Cohenca -- Healing of periapical lesions / Zvi Metzger and Anda Kfir -- Surgical endodontics : the complimentary approach / Richard Rubinstein and Alireza Aminlari -- Emerging technologies in root canal disinfection / Anil Kishen, Annie Shrestha, and Nestor Cohenca.
  • 2005 Springer
    E.J.H.J Wiertz and M. Kikkert, eds.
    The secretory capacity of a cell depends on the efficiency of endoplasmic reticulum-associated degradation / M. Molinari and R. Sitia -- Recognition and delivery of ERAD substrates to the proteasome and alternative paths for cell survival / A.A. McCracken and J.L. Brodsky -- CPY* and the power of yeast genetics in the elucidation of quality control and associated protein degradation of the endoplasmic reticulum / D.H. Wolf and A. Schäfer -- The role of the ubiquination machinery in dislocation and degradation of endoplasmic reticulum proteins / M. Kikkert, G. Hassink, and E. Wiertz -- The role of p97/Cdc48p in endoplasmic reticulum-associated degradation : from the immune system to yeast / S. Bar-Nun -- The ins and outs of intracellular peptides and antigen presentation by MHC Class I molecules / T. Groothuis and J. Neefjes -- Entry of protein toxins into mammalian cells by crossing the endoplasmic reticulum membrane : co-opting basic mechanisms of endoplasmic reticulum-associated degradation / J.M. Lord , L.M. Roberts, and W.I. Lencer.
    Also available: Print – 2005
  • 2008 ScienceDirect
    volume editors, G. Bryan Young and Eelco F.M. Wijdicks.
    Also available: Print – 2008
  • 2016 Springer
    Davide Martino, Alberto J. Espay, Alfonso Fasano, Francesca Morgante.
    Part 1: Poverty and slowness of voluntary movement: Bradykinesia, hypokinesia and akinesia -- Weakness -- Apathy, catatonia and mutism -- Obsessional slowness -- Part 2: Abnormalities of muscle tone: Spasticity -- Rigidity -- Paratonia -- Stiffness -- Atonia, hypotonia and negative myoclonus -- Part 3: Unvoluntary muscle activity: Tics -- Stereotypies and mannerisms -- Akathisia/restlessness -- Part 4: Lack of organization or coordination of voluntary muscle activity -- Apraxia -- Limb ataxia -- Part 5: Rhythmical involuntary movements: Tremor -- Tremor-like conditions: rhythmic myoclonus, myorhythmia, epileptic syndromes and clonus -- Part 6: Slow involuntary movements and abnormal posturing: Dystonia -- Spasms and cramps -- Myotonia and neuromyotonia -- Part 7: Rapid involuntary movements: Chorea/ballism -- Myoclonus and excessive startle -- Myokymia -- Part 8: Axial disorders of movement: Disorders of speech -- Disorders of stance -- Disorders of gait.
  • 2012 Springer
    John M. Hutson, Garry L. Warne, Sonia R. Grover, editors.
  • 2015 Springer
    Aleksandar Videnovic, Birgit Högl, editors.
    Part I -- 1. Introduction: Sleepy days and restless nights of Parkinson's Disease -- 2. Regulation of sleep and wake homeostasis -- 3. Neurochemistry of the sleep-wake cycle in Parkinson's disease -- 4. Impaired sleep and alertness in Parkinson's disease: what did we learn from animal models? -- 5. Objective measures of the sleep-wake cycle in Parkinson's disease -- 6. Subjective assessment of sleep and sleepiness in Parkinson's disease. Part II -- 7. Excessive daytime somnolence associated with Parkinson's disease -- 8. Insomnia in Parkinson's disease -- 9. Sleep-disordered breathing in Parkinson's disease -- 10. Restless legs syndrome and periodic limb movement disorder in Parkinson's disease -- 11. REM sleep behavior disorder -- 12. REM sleep behavior disorder: a pre-motor marker of Parkinson's disease -- 13. Dysregulation of circadian system in Parkinson's disease -- 14. Cognition and the sleep-wake cycle in Parkinson's disease -- 15. Fatigue and sleepiness in Parkinson's disease -- 16. Impact of surgical therapies on sleep and alertness in Parkinson's disease -- 17. Future directions.
  • 2015 Springer
    Ian A. Trail, Andrew N.M. Fleming, editors.
    This book comes at a time when significant advances in the understanding of hand disorders have resulted in vast improvements in the quality of life for patients. It describes the techniques and practices for the diagnosis and treatment of various disorders of the hand and wrist. Each condition is discussed in detail and illustrated with images, radiographs and line drawings. Clinical pearls are provided for every chapter to provide practical guidance on surgical procedures. Disorders of the Hand contains contributions from many of the hand surgeons who are at the forefront of this evolving area in the management of both elective and trauma hand surgery. This volume and its three sister volumes aim to improve care for current patients with hand and wrist complaints, while inspiring surgeons to think in greater detail about treatment options that will provide even better care in the future.
  • 2015 Springer
    Ian A. Trail, Andrew N.M. Fleming, editors.
    This book comes at a time when significant advances in the understanding of hand disorders have resulted in vast improvements in the quality of life for patients. It describes the techniques and practices for the diagnosis and treatment of various disorders of the hand and wrist. Each condition is discussed in detail and illustrated with images, radiographs and line drawings. Clinical pearls are provided for every chapter to provide practical guidance on surgical procedures. Disorders of the Hand contains contributions from many of the hand surgeons who are at the forefront of this evolving area in the management of both elective and trauma hand surgery. This volume and its three sister volumes aim to improve care for current patients with hand and wrist complaints, while inspiring surgeons to think in greater detail about treatment options that will provide even better care in the future.
  • 2015 Springer
    Ian A. Trail, Andrew N.M. Fleming, editors.
    This book comes at a time when significant advances in the understanding of hand disorders have resulted in vast improvements in the quality of life for patients. It describes the techniques and practices for the diagnosis and treatment of various disorders of the hand and wrist. Each condition is discussed in detail and illustrated with images, radiographs and line drawings. Clinical pearls are provided for every chapter to provide practical guidance on surgical procedures. Disorders of the Hand contains contributions from many of the hand surgeons who are at the forefront of this evolving area in the management of both elective and trauma hand surgery. This volume and its three sister volumes aim to improve care for current patients with hand and wrist complaints, while inspiring surgeons to think in greater detail about treatment options that will provide even better care in the future.
  • 2015 Springer
    Ian A. Trail, Andrew N.M. Fleming, editors.
    This book comes at a time when significant advances in the understanding of hand disorders have resulted in vast improvements in the quality of life for patients. It describes the techniques and practices for the diagnosis and treatment of various disorders of the hand and wrist. Each condition is discussed in detail and illustrated with images, radiographs and line drawings. Clinical pearls are provided for every chapter to provide practical guidance on surgical procedures. Disorders of the Hand contains contributions from many of the hand surgeons who are at the forefront of this evolving area in the management of both elective and trauma hand surgery. This volume and its three sister volumes aim to improve care for current patients with hand and wrist complaints, while inspiring surgeons to think in greater detail about treatment options that will provide even better care in the future.
  • 2008 Karger
    volume editors, C.E. Flück, Walter L. Miller.
    Steroidogenic enzymes / Miller, W.L. -- Disorders of adrenal development / Ferraz-de-Souza, B.; Achermann, J.C. -- Adrenal androgens in humans and nonhuman primates: production, zonation and regulation / Nguyen, A.D.; Conley, A.J. -- Clinical implications of androgen synthesis via 5[alpha]-reduced precursors / Ghayee, H.J.; Auchus, R.J. -- P450 oxidoreductase deficiency: a new form of congenital adrenal hyperplasia / Flück, C.E. ... [et al.] -- Long-term outcome of prenatal treatment of congenital adrenal hyperplasia / Lajic, S.; Nordenström, A.; Hirvikoski, T. -- Adrenocorticotropin resistance syndromes / Cooray, S.N. ... [et al.] -- Cushing Syndrome caused by adrenocortical tumors and hyperplasias (corticotropin-independent Cushing Syndrome) / Stratakis, S.A. -- The role of adrenal steroidogenesis in arterial hypertension / Mohaupt, M.G. -- Fetal programming of adrenal androgen excess: lessons from a nonhuman primate model of polycystic ovary syndrome / Abbott, D.H. ... [et al.].
  • 2015 Springer
    Janet Lioy, Steven E. Sobol, editors.
    Disorders of the Neonatal Airway serves as a comprehensive, multidisciplinary resource for all practitioners who care for neonates with airway disorders. With the evolution of advances in neonatology and neonatal airway care over the past three decades, the survival rate and life expectancy of premature newborns have dramatically increased to well over 50% in 24-25 week gestation infants. Unfortunately, survival with long-term intubation has brought a corresponding increase in acquired airway disorders needing collaborative high level neonatal and otolaryngological care. Additionally, with the advent of fetal therapy, congenital airway disorders now make up a substantial number of neonates with complex airway disorders. Because of this fact, there has been increased focus on the multidisciplinary evaluation and management of neonatal airway disorders. The book is organized into three sections: the first focuses on Malformations and Deformations, the second focuses on Assessment, Evaluation, and Treatment, and the third discusses Education, Simulation, and Quality. As one of the only comprehensive resources on the topic, Disorders of the Neonatal Airway focuses on a multidisciplinary approach to the neonatal airway. This unique approach makes this reference a must read for practitioners from many disciplines.
  • 2006 Springer
    [edited] by Matthew L. Mintz.
  • 2007 Ovid
    editors, Joseph P. Iannotti, Gerald R. Williams, Jr.
    Also available: Print – v. 1-2., 2007
  • 2015 Springer
    Hannah Cohen, Patrick O'Brien, editors.
  • 2012 Springer
    Hannah Cohen, Patrick O'Brien, editors.
  • 2016 Springer
    Rade B. Vukmir.
    This book explores a rapidly growing area of discussion in the health care industry, disruptive behavior in medical providers. The presence of disruptive behavior adversely impacts the providers of all disciplines: paraprofessional personnel, nurses, physicians and administrators. But more importantly, there may be a greater detrimental effect on quality and patient safety. This has led to mandated regulatory requirements that assist healthcare institutions in developing programs to address the problem. The book presents an evidence-based analysis of the disruptive provider behavior that defines the incidence, demographics, and profile of the behavior; discusses the specialties and work locations predisposed, as well as the interface with residents and nurses. The importance of patient safety, economic, and legal issues are addressed by a comprehensive, management strategy to effect positive, sustainable culture change in healthcare.
  • 2013
    Dustin Howard Hite.
    The central dogma of biology states that DNA, the genetic information, is transcribed into RNA, an information containing intermediate, which is then translated into proteins, actionable molecules which perform the majority of tasks required for life. To synthesize proteins, the cell employs a massive, macromolecular machine, the ribosome, and a myriad of protein factors to successfully translate an mRNA. My graduate studies have focused both on the ribosome and the protein translation factors that interact with the ribosome to facilitate translation initiation, elongation, and termination. First, utilizing recent advances in high throughput sequencing, we discovered that sequencing of ribosome protected fragments could illuminate in vivo dynamics of ribosome structural changes in Saccharomyces cerevisiae. We demonstrated that the ribosome protects two distinct sizes of fragments and assigned each fragment population to approximate stages of the translation elongation cycle where large structural rearrangements of the ribosome are known to occur. Once these assignments were made, we were able to model elongation speed and demonstrated that, contrary to previous reports, tRNA abundance and codon optimality were not the major determinants of elongation speed; surprisingly our data indicated that the polarity of the amino acid being decoded dictated elongation rates under these conditions, with polar amino acids acting to slow elongation rates. This study also implicated Dom34, a known NO GO decay factor, as a novel component of canonical translation termination and ribosome recycling. Second, we used another genome-wide assay of translation, "gradient encoding" microarray analysis, to interrogate the genome-wide effects of depleting five individual translation factors. Based on the current understanding of the molecular mechanisms of each translation factor, we hypothesized that the depletion of each factor would result in differential translation of mRNAs based on the physical properties of each mRNA species. However, we were startled to observe that the translational program of S. cerevisiae was relatively unperturbed by the depletion of three initiation factors, one elongation factor, and one termination factor. Further investigation revealed that yeast were actively compensating for the deficiency of each factor by either increasing or decreasing translation initiation rates such that the depleted factor was no longer limiting. This tuning was mediated by changes in eIF2[alpha] phosphorylation levels, a known modulator of translation initiation. Overall, we have leveraged high throughput technologies to provide novel understanding of in vivo structural dynamics of the ribosome and reveal a novel, unexpected robustness of the translational program in S. cerevisiae.
  • 2012
    Aaron Webster Puri.
    Host-pathogen interactions are highly regulated at the post-translational level, making small molecules useful tools for dissecting many aspects of these events. This dissertation describes the development and application of chemical probes to examine aspects of bacterial infection on either side of the host-pathogen interface. We rationally designed a set of inhibitors and activity-based probes to study the substrate recognition and activation mechanisms of the internal cysteine protease domain (CPD) of Clostridium difficile's large gluocosylating toxin TcdB; a major virulence factor of this important nosocomial pathogen. Subsequent work with these tools has helped elucidate the biochemical details of CPD allosteric activation within a eukaryotic environment, and has provided evidence that TcdB contributes to hypervirulence in some C. difficile strains. We also developed an optimized activity-based probe for studying inflammasome-mediated caspase-1 activation, which is a fundamental part of the host's response to intracellular bacterial pathogens. We used this tool to discover that when cells are unable to activate caspase-1 upon intracellular bacterial infection, they instead undergo apoptosis. This work provides insight into a potential intracellular arms race between the host and pathogens capable of suppressing caspase-1 activation, and also highlights the balance that exists between pro- and non-inflammatory cellular responses. Together, these studies show there is much to be gained from adding chemical probes to the repertoire of tools used to study mechanisms of bacterial pathogenesis.
  • 2011
    Jennifer Hwa.
    Neurons are morphologically diverse, with many anatomical specializations that are crucial for their functions. Photoreceptors represent a specialized class of neurons whose elaborated apical structures, the rhabdomeres, and specific axonal projections collect visual stimuli and transmit them to the appropriate synaptic partners, forming the basis for vision. Through genetic analyses in the Drosophila visual system, we have studied the molecular mechanisms that control these two aspects of photoreceptor morphology. A forward genetic screen identified the GTPase effector Genghis khan (Gek) as mediating the ability of a subset of photoreceptor neurons to target to their appropriate postsynaptic columns. Gek was not required for the layer targeting of a different subset of photoreceptors; however ectopic expression in these cells was sufficient to affect their targeting choices. Regulation of Gek's responses to targeting cues may underlie differences in target choices among photoreceptors. The specification of photoreceptor apical structures depends on genes of the apical -- basal polarity family. Mutants in the genes Crumbs (Crb) and Stardust (Sdt) are required for rhabdomere development in distinct but overlapping subsets of photoreceptors. In addition, both genes are required in all cell types for the formation of the adherens junctions contacts between cells, suggesting that Crb and Sdt have both overlapping and unique functions in photoreceptor morphogenesis. Thus, these experiments provide insight into how two aspects of photoreceptor morphology are determined, and suggest mechanisms by which cell type specific morphologies may be produced.
  • 2012
    Patrick Evan Bogard.
    One of the challenges facing modern medicine is to understand mammalian organ formation. Each organ has a specialized function and form, yet they are built from similar parts. One important part of each organ is the circulatory system, composed of arteries, veins, and capillaries, which is responsible for delivery of oxygen and nutrients and for the removal of carbon dioxide and metabolic waste. For centuries scientists have been trying to understand how the circulatory system functions and more recently how it forms. In this thesis, I focus on the development of the mouse pulmonary vasculature, the circulatory system that is responsible for transporting blood from the heart to the lungs where oxygenation occurs, and back to the heart where the oxygenated blood is pumped throughout the body. The lung is a complex organ made up of multiple hollow airway tubes that must form in coordination so that proper gas exchange can occur. In the first chapter I review the function and development of the circulatory system. In chapter two I present the experiments completed to determine the cellular origins of the blood vessels of the mouse lung and heart. Currently there are two major models for how the pulmonary arteries of the mouse form, vasculogenesis of lung mesenchymal endothelial progenitors and sprouting angiogenesis from vessels outside the lung. Using fate mapping I directly test the dominant model, vasculogenesis, and show that there are no endothelial progenitor cells resident in the lung mesenchyme. To determine if a vessel outside the lung is forming the pulmonary arteries I performed a clonal analysis labeling single endothelial cells before pulmonary artery formation and followed the fates of their daughter cells. I found a surprising multipotent progenitor population of endothelial cells, the primitive plexus of the lung, that gives rise to pulmonary arterial, venous, and plexus endothelial cells. I showed that the transition from plexus to arterial fate occurs in a leakproof manner in the lung by performing intracardiac perfusion experiments of fluorescently labeled dextrans and lectins. I also demonstrated a similar mechanism of leakproof plexus remodeling occurs in the heart during the development of the coronary arteries and veins. In chapter three I discuss experiments done to understand the molecular mechanisms controlling pulmonary artery formation. I describe an in silico in situ hybridization screen I performed to identify candidate molecules. I describe the expression pattern of BMP pathway activity in the lung as being restricted to the pulmonary arteries, a subset of the plexus and budding airways, using a transgenic mouse line that is only expressed in cells actively undergoing BMP signaling. I analyzed mice homozygously deficient for the BMP antagonists Gremlin and BMPER, and showed that there is no abnormal pulmonary artery formation or patterning phenotype. I also describe experiments in which I have deleted the BMP Receptor 2 from endothelial cells and again there is no abnormal pulmonary artery formation or patterning phenotype. I describe the expression pattern of VEGF in the lung as being mesenchymal during early lung formation, and show that mesenchymal deletions of VEGF do not result in abnormal pulmonary artery formation or patterning phenotypes. I found that multiple single gene manipulations do not result in abnormal phenotypes suggesting that pulmonary artery formation and patterning is robust and likely involves the interaction of multiple signaling pathways. This work describes a common mechanism of organ specific vascular bed formation that has not been previously described at a cellular and molecular level. I hope these studies provide a foundation for understanding how the vascular system of many organs form during organogenesis.
  • 2013
    Molly Pleasants Lowndes.
    During normal development, tissue regeneration and cancer, epithelia undergo dramatic morphogenetic processes, ranging from cohesive sheet migration, cell position changes within cohesive tissues, to individual cell migration after dissociation from tissues. Such cell movements require coordination between cell migration and intercellular adhesion to maintaining tissue integrity. In epithelial cells, cell-cell adhesion complexes comprised of cadherins are crucial for these processes. I have investigated the unique roles of different cadherins in assembling adhesion complexes and coordinating migration. I show that cadherins are crucial for directing cellular migration, which is key for processes such as wound healing. The effect on cellular motility depends on the type of cadherin and the corresponding cell-cell complex involved. I show that the two types of desmosomal cadherins, which make up the desmosome, have distinct properties. Thus modulation of desmosomal cadherin interactions during development and cancer may provide a range of adhesive strengths that contributes to the regulation of morphogenetic cell movements.
  • 2012
    Bradford Albert Bouley.
    This dissertation explains how the body provided proof of holiness in early modern Catholicism. Tradition had long asserted that the bodies of especially saintly or sinful individuals should reveal signs of their elect status. In the early modern period, Church officials sought to make such vague ideas exact: they required medical proof of bodily holiness. This requirement arose out of developments in both medicine and Catholicism. After the Reformation, many Christians doubted how or even if they should venerate the saints. In response, the Catholic Church centralized and formalized canonization procedures. As part of this reform, canonization officials began to require that medical practitioners examine the cadavers of holy individuals. Medical and anatomical knowledge had progressed during this period to the point where dissection was thought to yield unique information about the lifestyle and habits of the deceased. This information could also include signs of a person's spiritual state. The body, interpreted through expert eyes, could now reveal a person's true nature. Together, medical practitioners and canon lawyers in the city of Rome created standards through which to interpret bodily signs of holiness. The methods of proof employed in these examinations presaged many techniques of knowledge production that would become a part of experimental practice in the early modern world. This dissertation therefore demonstrates that instead of being opposed, science and religion worked together to define the boundaries of the natural in human bodies.
  • 2011
    Kaitian Peng.
    Francisella is a gram-negative bacterium that causes tularemia. It is capable of infecting a remarkably broad host range including humans, mammals, birds and fish via multiple different routes of infection, establishing a successful colonization event within the various organs. This facultative, intracellular pathogen is also capable of invading a broad range of host cell types ranging from macrophages to fibroblasts. This is an extremely fascinating facet of the bacterium. The ability of Francisella to infect such a wide range of hosts and cell types suggests that the bacterium either co-opts cellular mechanisms common to all hosts and cell types or has the requisite bacterial genes to adapt to many different intraorganismal environments, or both. We were interested in studying the diverse repertoire of interactions that may occur between the bacterium and its murine host. In this thesis, the transposon site hybridization (TraSH) negative selection strategy was applied in a range of in vivo and in vitro systems to identify novel host-pathogen interactions in Francisella. We subsequently demonstrated that Francisella require tryptophan for virulence specifically in the lungs due to lung-specific induction of a host innate immune molecule indoleamine 2,3-dioxygenase 1. Alveolar macrophages may also deplete intracellular trytophan via a novel mechanism and microbial lung-specific requirement of tryptophan for virulence may be widely applicable to all bacterial species. We also demonstrate that Francisella hypercytotoxic mutants, unlike previously suggested, induce macrophage hypercytotoxicity due to increased bacteriolysis in the intracellular milieu. Identification and characterization of bacterial mutants that are attenuated under different in vitro and in vivo conditions have led to further insights into the interactions that occur between Francisella and its murine host.
  • 2005 Springer
    Michael R. Emmert-Buck, John W. Gillespie, Rodrigo F. Chuaqui, (eds.).
  • 2013
    Limor Freifeld.
    Visual inputs are high-dimensional, dynamic, and may consist of significant levels of noise. Nevertheless, visual processing systems in many animals are capable of efficiently extracting information out of these signals to guide behavior. Flies, in particular, use visual information to guide behavior in challenging conditions such as during rapid flight maneuvers. In this dissertation we examine how early visual processing cells in the visual system of the Fruit Fly, Drosophila, achieve this feat. In particular, we focus on cells that provide inputs to motion detecting circuits and assess how these cells balance the goal of facilitating computational specializations with the goal of efficiently capturing all visual information. In these studies, we used two-photon calcium imaging in vivo to monitor the responses of specific cells in the fly visual system to visual stimuli. Using this system, we found that two first order interneurons providing inputs to pathways specialized for the detection of moving bright and dark edges nevertheless similarly encode information about both brightening and darkening. However, an in depth study of the functional properties of one of these interneurons revealed that it responds differently to bright and dark moving objects of different sizes in a manner that could facilitate the downstream specialization. Furthermore, via genetic and pharmacological manipulations it was found that GABAergic circuits providing lateral and feedback inputs to this cell enhance its responses to dark stimuli and thus enable it to relay critical information for the downstream pathway. These circuits were found to give rise to a center-surround antagonistic, anisotropic and spatiotemporally coupled RF structure in this cell. Interestingly, our studies uncovered deep similarities between the function of early visual processing cells in the fly and in vertebrate retinas. This suggests that different systems have converged on a similar set of solutions for addressing the challenge of efficiently using the resources available to the nervous system to process visual signals.
  • 2012
    T.D. Barbara Nguyen-Vu.
    The focus of this thesis is to understand the contribution of multiple learning mechanisms to cerebellum-dependent motor learning. The studies that contribute to this thesis examine the role multiple learning mechanisms in the context of signaling in the intact circuit of awake-behaving animals. By using a well-parameterized learning paradigm, it is possible to distinguish and separate the contribution of specific learning mechanisms to different aspects of learning. This thesis demonstrates the sufficiency to two learning mechanisms long hypothesized to be important for cerebellum-dependent learning: 1) LTD at the parallel fiber to Purkinje cell synapse in the cortex (Marr 1969; Albus 1971; Ito 1972); and 2) the output of Purkinje cell simple spike activity (Miles & Lisberger 1981). Furthermore, the findings highlight the importance of understanding how learning mechanisms operate in vivo and interact with the on-going activity as well as previous activity in the circuit to determine different learning outcomes. The idea that the properties of a learning mechanism do not operate in isolation to produce learning but must be considered in the context of the intact and functional circuit is a common lesson that could apply to and should be tested in other learning systems of the brain.
  • 2011
    Sarah King Jarchow-Choy.
    This thesis is composed of two separate studies involving unnatural nucleoside (DNA) analogs in two different types of enzymes: human thymidine kinases 1 and 2 and terminal deoxynucleotidyl transferase (TdT). The ability of two types of unnatural DNA analogs, nonpolar nucleoside analogs and expanded nucleoside analogs, to act as efficient substrates in enzymes will be described. Nonpolar nucleoside analogs lacking the ability to hydrogen bond were synthesized to systematically vary in size and shape, and then used to probe the ability of two types of human thymidine kinases (TK1 and TK2) to recognize and phosphorylate these analogs. The results establish that nucleoside recognition mechanisms for these two classes of thymidine kinase are very different. On the basis of this data, nonpolar nucleosides are likely to be active in the nucleotide salvage pathway in human cells, suggesting new designs for bioactive molecules. Another class of nucleoside analogs, expanded nucleoside (xDNA) analogs, maintain the ability to hydrogen-bond to their respective natural bases, but have enhanced pi-stacking due to their larger size, allowing the molecule to have greater stability in a DNA duplex, and unique fluorescent properties. It was found that terminal deoxynucleotidyl transferase (TdT), a template-independent DNA polymerase, can accept multiple xDNA nucleotide analogs as substrates with efficiencies close to that of natural nucleotides. In addition, the expanded adenine (xA) and cytosine (xC) analogs show a visible and spectral change in fluorescence when TdT incorporates multiple analogs. The ease of enzymatic synthesis of these analogs and their inherent fluorescence suggest their use in nucleic acid labeling and hybridization studies. The comparable efficiencies which nonpolar nucleoside analogs and xDNA nucleotide analogs have to natural bases in thymidine kinases and TdT give new information about the steric and electronic requirements of these enzymes, and will be useful for potential therapeutic and biotechnological applications.
  • 2014 Springer
    Leiv M. Hove, Tommy Lindau, Per Hølmer, editors.
    Distal radial fractures are still puzzling us 200 years after Colles' classic description. Despite the advent of various new imaging techniques, including 3D CT, the availability of diagnostic adjuncts such as arthroscopy, and treatment options that include more than 30 different volar locking plates, the rate of unsatisfactorytreatment resultsremains very high. Furthermore, while we are aware of more associated injuries, such as carpal ligament tears and injuries to the radioulnar ligament (TFCC), there is still intense debate on the relevance of these injuries. This textbook aims to provide the reader with a complete understanding of distal radius fractures, their inherent problems, and how to manage them successfully. It is written by widely published experts from a part of the globe where distal radius fractures are very common, especially during the winter months. Clear guidance is provided on diagnostic imaging, classification, and assessment of fracture instability. The complete spectrum of operative and nonoperative treatment options are then clearly explained with the aid of step-by-step illustrations. Extensive information is also provided on complications and their treatment. Both students and experienced practitioners will find this book to be an enlightening, practice-oriented reference on the management of these challenging fractures.
  • 2009
    Christopher Brian Franco.
    Status: Not Checked OutLane Catalog Record
  • 2007 Springer
    Werner Dubitzky, Assaf Schuster, Peter M.A. Sloot, Michael Schroeder, Mathilde Romberg (eds.).
  • 2007 Springer
    A.B. Tonchev, T. Yamashima, G.N. Chaldakov.
  • 2010 Springer
    M. Celeste Simon, editor.
    The HIF-2[alpha]-driven pseudo-hypoxic phenotype in tumor aggressiveness, differentiation, and vascularization / A. Pietras, A.S. Johnsson and S. Pahlman -- Hypoxia and hypoxia inducible factors in cancer stem cell maintenance / Z. Li and J.N. Rich -- Role of carcinoma-associated fibroblasts and hypoxia in tumor progression / A.J. Giaccia and E. Schipani -- The role of hypoxia regulated microRNAs in cancer / R. McCormick ... [et al.] -- Oxygen sensing: A common crossroad in cancer and neurodegeneration / A. Quaegebeur and P. Carmeliet -- Hypoxia-inducible factors as essential regulators of inflammation / H.Z. Imtiyaz and M.C. Simon -- Hypoxia and metastasis in breast cancer / H. Rundqvist and R.S. Johnson.
    Also available: Print – 2010
  • 2008 Springer
    M. Shakibaei, C. Csaki, and A. Mobasheri.
  • 2008
    OSHPD Healthcare Workforce Diversity Advisory Council.
  • 2013
    Janice L. Dreachslin, M. Jean Gilbert, Beverly Malone.
    Status: Not Checked OutLane Catalog Record
    "Designed to provide ... a clear understanding of recent philosophies and processes undergirding diversity management, inclusion, and culturally competent care delivery as seen through the lens of current health care policy and practice. The textbook integrates strategic diversity management, self-reflective leadership and the personal change process, with culturally and linguistically appropriate care into a cohesive systems-oriented approach for health care professionals"--Excerpt from publisher notes.
  • 2016 Springer
    Marcus L. Martin, Sheryl L. Heron, Lisa Moreno-Walton, editors ; Anna Walker Jones, managing editor.
    Defining Diversity in Quality Care -- Racial/Ethnic Healthcare Disparities and Inequities: Historical Perspectives -- Educating Medical Professionals to Deliver Quality Health Care to Diverse Patient Populations -- Culturally Competent Faculty -- Culturally Sensitive Care: A Review of Models & Educational Methods -- Interpreter Services -- The Patient-Physician Clinical Encounter -- Spiritual Care Services in Emergency Medicine -- Lesbian, Gay, or Bisexual (LGB): Caring with Quality and Compassion -- Culturally Competent Care of the Transgender Patient -- Looking Past Labels: Effective Care of the Psychiatric Patient -- Disability and Access -- Racial and Ethnic Disparities in the Emergency Department: A Public Health Perspective -- Vulnerable Populations: The Homeless and Incarcerated -- Vulnerable Populations: The Elderly -- Vulnerable Populations: Children -- Religio-cultural Consideration When Providing Healthcare to American Muslims -- Disparities and Diversity in Biomedical Research -- Cultural Competency Case Studies: Transitional Introduction -- Case 1: African-American Infant and Family -- Case 2: Cambodian Refugee -- Case 3: Sickle Cell Crisis -- Case 4: Mongolian Spots -- Case 5: Death Disclosure -- Case 6: Coin Rubbing -- Case 7: Toxic Ingestion -- Case 8: Adolescent Indian Male Sikh -- Case 9: Intimate Partner Violence in the Gay Community -- Case 10: West Indian/Caribbean -- Case 11: American Indian -- Case 12: Spiritualism in the Latino Community -- Case 13: Islamic Patient -- Case 14: Pediatric Pain.
  • 2009
    Phillip R. Lee and Patricia E. Franks.
    Executive summary -- Preface -- ch. 1. Changing opportunities and challenges for medical schools: from desegregation to affirmative action to promoting diversity in an anti-affirmative action environment -- ch. 2. Increasing access to U.S. medical schools for diverse populations: demographic, education, and medical school trends, 1960s-2000s, graduate medical education, and the U.S. physican workforce -- ch. 3. The Changing federal context -- ch. 4. California's people: demographic transformation, educational trends, and challenges for medical school and physician diversity -- ch. 5. California's changing policy context -- ch. 6. The University of California: the changing policy context of a public university -- ch. 7. Stanford University: the changing policy context of a private university -- ch. 8. Case studies of diversity: UCSF and Stanford medical schools -- ch. 9. Recommendations: opportunities for action to increase diversity -- Appendix 1. Archival research -- Appendix 2. Key informant interviews -- Appendix 3. Oral history interviews -- Appendix 4. Selected key reports related to diversity in medical schools and the health professions and the physician workforce.
  • 2005 Springer
    M. Kaminishi, K. Takubo, K. Mafune (eds.).
  • 2014
    Karen Speerstra, Herbert Anderson ; foreword by Ira Byock, MD.
    Status: Not Checked OutLane Catalog Record
    "The Divine Art of Dying" explores the unique moment when seriously ill people choose to turn toward death. Combining personal stories with solid research on palliative and hospice care, it provides a well-integrated look at the spiritual dimensions of living fully when death is near. Filled with insights from the world's great wisdom traditions along with references from literature, movies, and current culture, it helps identify the life decisions the dying one and his or her loved ones must make, and what their caregivers can expect.
  • 2013 IngentaConnect
    Christi Sumich.
    Divine Doctors and Dreadful Distempers examines the discourse of seventeenth-century English physicians to demonstrate that physicians utilized cultural attitudes and beliefs to create medical theory. They meshed moralism with medicine to self-fashion an image of themselves as knowledgeable health experts whose education assured good judgment and sage advice, and whose interest in the health of their patients surpassed the peddling of a single nostrum to everyone.
    Also available: Print – 2013
  • 2013 Springer
    Matjaž Vogelsang, editor.
    Lynch syndrome (LS) is the most common cause of inherited colorectal cancer, a disease with a high mortality rate. An estimated 37,000 of diagnosed colorectal cancer cases worldwide are attributed to Lynch syndrome each year. Intensive cancer screening, with early initiation and frequent follow-up, can reduce colorectal cancer incidence and mortality in LS patients. This book provides an up-to-date overview on the genetic and epigenetic basis of Lynch syndrome. It evaluates clinical features of the disease and critically comments on molecular tools available for identifying mutations responsible for Lynch syndrome; in addition the importance of functional assays that can help clarify the clinical nature of identified mutations is also discussed. The book also focuses on challenges in genetic counselling of at-risk individuals and discusses related ethical issues. The purpose of the book is to give a concise knowledge base for the broader scientific and medical community, including genetic counselors, in order to improve awareness on the potential impact that the diagnosis of LS has on treatment, management and surveillance of LS patients.
  • 2014 CRCnetBASE
    Amanda C Sozer, PhD.
    1. Human identification through DNA analysis -- 2. Mass fatalities -- 3. Postmortem functions : body recovery and morgue operations -- 4. Antemortem functions : family assistance operations -- 5. Identification of remains -- 6. Identification and collection of biological samples from human remains -- 7. Identification and collection of DNA reference samples -- 8. Application of DNA technology for human identification -- 9. DNA profile analysis and interpretation -- 10. DNA sample, case, and data tracking using information technology tools -- 11. Implementing and maintaining a quality DNA program -- 12. Laboratory development -- 13. Delivering effective training.
  • 2013 Springer
    Volker A. Erdmann, Jan Barciszewski, editors.
    DNA and RNA nanobiotechnologies have currently reached the status of one of the most dynamic research areas in the field of drug delivery in molecular medicine. Scientists and bio-engineers are creating totally new nanometer-scale structures with unique biological properties for a wide range of medical applications. The book, written by world-leading scientists in this new field, gives an overview of various aspects and applications of DNA and RNA nanotechnologies. These include the design and synthesis of DNA and RNA nanostructures with the aim of using them for different kinds of drug deliveries, for genetic immunization, for metabolite and nucleic acid detection, gene regulation, siRNA delivery for cancer treatment, and even analytical and therapeutic applications of aptamer-based nanoparticles. This volume will be of interest not only to graduate students and researchers in the field of molecular medicine and molecular biology, but also to chemists interested in the biological fields. As a matter of fact, the book contains so many new and unique approaches to this area of molecular medicine that it may inspire the interested reader to undertake research into nucleic acid nanotechnologies.
  • 2009 Springer Protocols
    edited by Peter Bugert.
    PCR-ELISA for high-throughput blood group genotyping / Maryse St-Louis -- Single base extension in multiplex blood group genotyping / Gregory A. Denomme -- Real-time PCR assays for high-throughput blood group genotyping / Fernando Araujo -- Real-time PCR assays for high-throughput human platelet antigen typing / Simon E. McBride -- Multiplex ABO genotyping by minisequencing / Gianmarco Ferri and Susi Pelotti -- Multiplex genotyping for thrombophilia-associated SNPs by universal bead arrays / Susan Bortolin -- Pyrosequencing of toll-like receptor polymorphisms of functional relevance / Parviz Ahmad-Nejad -- Multiplex HLA-typing by pyrosequencing / Ying Lu ... [et al.] -- High-throughput multiplex HLA-typing by ligase detection reaction (LDR) and universal array (UA) approach / Clarissa Consolandi -- Medium- to high-throughput SNP genotyping using VeraCode microbeads / Charles H. Lin ... [et al.] -- The use of maternal plasma for prenatal RhD blood group genotyping / Kirstin Finning, Pete Martin, and Geoff Daniels -- Nanoliter high-throughput PCR for DNA and RNA profiling / Colin J.H. Brenan, Douglas Roberts, and James Hurley -- RNA stabilization of peripheral blood and profiling by bead chip analysis / Svenja Debey-Pascher, Daniela Eggle, and Joachim L. Schultze -- RNA profiling in peripheral blood cells by fluorescent differential display PCR / Martin Steinau and Mangalathu S. Rajeevan -- cDNA amplification by SMART-PCR and suppression subtractive hybridization (SSH)-PCR / Andrew Hillmann, Eimear Dunne, and Dermot Kenny -- Transcript profiling of human platelets using microarray and serial analysis of gene expression (SAGE) / Dmitri V. Gnatenko ... [et al.] -- Genome-wide platelet RNA profiling in clinical samples / Angelika Schedel and Nina Rolf -- PCR-based amplification of platelet mRNA sequences obtained from small-scale platelet samples / Jutta M. Rox, Jens Müller, and Bernd Pötzsch -- MicroRNA profiling of megakaryocytes / Ramiro Garzon -- Serial analysis of gene expression adapted for downsized extracts / SAGE/SADE) analysis in reticulocytes / Béatrice Bonafoux and Thérèse Commes -- Real-time PCR analysis for blood cell lineage specific markers / Louise Edvardsson and Tor Olofsson -- Monitoring the immune response using real-time PCR / Patrick Stordeur.
  • 2002 CRCnetBASE
    edited by Elena V. Grigorenko.
  • 2012 Springer Protocols
    edited by W. John Kress and David L. Erickson.
    DNA barcodes : methods and protocols / W. John Kress and David L. Erickson -- Introduction to animal DNA barcoding protocols / Lee A. Weigt [and others] -- DNA barcodes for insects / John James Wilson -- DNA barcoding methods for invertebrates / Nathaniel Evans and Gustav Paulay -- DNA barcoding amphibians and reptiles / Miguel Vences [and others] -- DNA barcoding fishes / Lee A. Weigt -- DNA barcoding birds : from field collection to data analysis / Dario A. Lijtmaer [and others] -- DNA barcoding in mammals / Natalia V. Ivanova, Elizabeth L. Clare, and Alex V. Borisenko -- Methods for DNA barcoding of fungi / Ursula Eberhardt -- Methods for DNA barcoding photosynthetic protists emphasizing the macroalgae and diatoms / Gary W. Saunders and Daniel C. McDevit -- DNA barcoding methods for land plants / Aron J. Fazekas [and others] -- Field information management systems for DNA barcoding / John Deck [and others] -- Laboratory information management systems for DNA barcoding / Meaghan Parker [and others] -- DNA extraction, preservation, and amplification / Thomas Knebelsberger and Isabella Stoger -- DNA mini-barcodes / Mehrdad Hajibabaei and Charly McKenna -- Ways to mix multiple PCR amplicons into single 454 run for DNA barcoding / Ryuji J. Machida and Nancy Knowlton -- Practical evaluation of DNA barcode efficacy / John L. Spouge and Leonardo Marino-Ramirez -- Plant DNA Barcodes, Taxonomic Management and Species Discovery in Tropical Forests / Christopher W. Dick and Campbell O. Webb -- Construction and Analysis of Phylogenetic Trees Using DNA Barcode Data / David L. Erickson and Amy C. Driskell -- Phylogenetic analyses of ecological communities using DNA barcode data / Nathan G. Swenson -- FISH-BOL, a case study for DNA barcodes / Robert D. Ward -- Generating plant DNA barcodes for trees in long-term forest dynamics plots / W. John Kress, Ida C. Lopez, and David L. Erickson -- Future directions / David L. Erickson and W. John Kress.
  • 2014 Springer Protocols
    edited by Svein Valla and Rahmi Lale.
    1. BioBrick assembly standards and techniques and associated software tools / Gunvor Røkke, Eirin Korvald, Jarle Pahr, Ove Øyås and Rahmi Lale -- 2. Plasmid construction by SLIC or sequence and ligation- independent cloning / Ryan E. Hill and Julian J. Eaton-Rye -- 3. Quick and clean cloning / Frank Thieme and Sylvestre Marillonnet -- 4. Hierarchical ligation-independent assembly of PCR fragments / Jonathan L. Schmid-Burgk, Zhen Xie, and Yaakov Benenson -- 5. USER-derived cloning methods and their primer design / Bo Salomonsen, Uffe H. Mortensen, and Barbara A. Halkier -- 6. Application of the restriction-free (RF) cloning for multicomponents assembly / Yoav Peleg and Tamar Unger -- 7. A single-tube assembly of DNA using the transfer-PCR (TPCR) platform / Ariel Erijman, Julia M. Shifman, and Yoav Peleg -- 8. Circular polymerase extension cloning / Jiayuan Quan and Jingdong Tian -- 9. Golden gate cloning / Carola Engler and Sylvestre Marillonnet -- 10. Design and construction of multigenic constructs for plant biotechnology using the goldenbraid cloning strategy / Alejandro Sarrion-Perdigones, Jorge Palaci, Antonio Granell and Diego Orzaez -- 11. FX cloning : a simple and robust high-throughput cloning method for protein expression / Eric R. Geertsma -- 12. Minimum GC-rich sequences for overlap extension PCR and primer annealing / Mikiko Nakamura, Ayako Suzuki, Hisashi Hoshida and Rinji Akada -- 13. Simple cloning and DNA assembly in Escherichia coli by prolonged overlap extension PCR / Chun You and Y.-H. Percival Zhang -- 14. Combinatorial assembly of clone libraries using site-specific recombination / Vanessa E. Wall, Leslie A. Garvey, Jennifer L. Mehalko, Lauren V. Procter and Dominic Esposito -- 15. Application of In-Fusion [trademark] cloning for the parallel construction of E. coli expression vectors / Louise E. Bird, Heather Rada, John Flanagan, Jonathan M. Diprose, Robert J.C. Gilbert and Raymond J. Owens -- 16. Seamless ligation cloning extract (SLiCE) cloning method / Yongwei Zhang, Uwe Werling, and Winfried Edelmann -- 17. j5 DNA assembly design automation / Nathan J. Hillson -- 18. FastPCR software for PCR, in silico PCR, and oligonucleotide assembly and analysis / Ruslan Kalendar, David Lee, and Alan H. Schulman.
  • 2008 Springer
    Max H. Garzon, Hao Yan (eds.).
  • 2008 Springer
    Karl-Heinz Zimmermann, Zoya Ignatova, Israel Martinez-Perez.
  • 2005 Springer
    [edited by] Takashi Ohyama.
    DNA: alternative conformations and biology / Vladimir N. Potaman and Richard R. Sinden -- Sequence-dependent variability of B-DNA: an update on bending and curvature / Victor B. Zhurkin ... [et al.] -- Curved DNA and prokaryotic promoters: a mechanism for activation of transcription / Munehiko Asayama and Takashi Ohyama -- Repression of transcription by curved DNA and nucleoid protein H-NS: a mode of bacterial gene regulation / Cynthia L. Pon, Stefano Stella and Claudio O. Gualerzi -- Curved DNA and transcription in eukaryotes / Takashi Ohyama -- Putative roles of kin17, a mammalian protein binding -- Curved DNA, in transcription / Jaime F. Angulo ... [et al.] -- Roles for Z- and double-stranded RNA in transcription: encoding genetic information by shape rather than by sequence / Alan Herbert -- Do DNA triple helices or quadruplexes have a role in transcription? / Michael W. Van Dyke -- Nucleic acid structures and the transcription defects in fragile X syndrome and Friedreich's ataxia / Karen Usdin -- Possible roles of DNA supercoiling in transcription / Susumu Hirose and Kuniharu Matsumoto -- Gene regulation by HMGA and HMGB chromosomal proteins and related architectural DNA-binding proteins / Andrew A. Travers -- Molecular mechanisms of male sex determination: the enigma of SRY / Michael A. Weiss -- The role of unusual DNA structures in chromatin organization for transcription / Takashi Ohyama -- DNA bendability and nucleosome positioning in transcriptional regulation / Mensur Dlaki, David W. Ussery and Sren Brunak.
  • v. 1-3, 1998-2001
    edited by Jac A. Nickoloff and Merl F. Hoekstra.
    Status: Not Checked OutLane Catalog Record
    v. 1. DNA repair in prokaryotes and lower eukaryotes -- v. 2. DNA repair in higher eukaryotes -- v. 3. Advances from phage to humans.
  • 2009 Springer Protocols
    edited by Vladimir V. Didenko.
    In situ detection of apoptosis by the TUNEL assay: An overview of techniques -- Combination of TUNEL assay with immunohistochemistry for simultaneous detection of DNA fragmentation and oxidative cell damage -- EM-ISEL: A useful tool to visualize DNA damage at the ultrastructural level -- In situ labeling of DNA breaks and apoptosis by T7 DNA polymerase -- In situ ligation: A decade and a half of experience -- In situ ligation simplified: Using PCR fragments for detection of double-strand DNA breaks in tissue sections -- 5'OH DNA breaks in apoptosis and their labeling by topoisomerase-based approach -- Detection of DNA strand breaks in apoptotic cells by flow- and image-cytometry -- Fluorochrome-labeled inhibitors of caspases: Convenient in vitro and in vivo markers of apoptotic cells for cytometric analysis -- Combining fluorescent in situ hybridization with the comet assay for targeted examination of DNA damage and repair -- Simultaneous labeling of single- and double-strand DNA breaks by DNA breakage detection-FISH (DBD-FISH) -- Co-localization of DNA repair proteins with UV-induced DNA damage in locally irradiated cells -- Ultrasound imaging of apoptosis: Spectroscopic detection of DNA-damage effects at high and low frequencies -- Quantifying etheno-DNA adducts in human tissues, white blood cells, and urine by ultrasensitive (32)P-postlabeling and immunohistochemistry -- ELISpot assay as a tool to study oxidative stress in peripheral blood mononuclear cells -- Cytokinesis-block micronucleus cytome assay in lymphocytes -- Buccal micronucleus cytome assay -- [Gamma]-H2AX detection in peripheral blood lymphocytes, splenocytes, bone marrow, xenografts, and skin -- Immunologic detection of benzo(a)pyrene-DNA adducts -- Non-invasive assessment of oxidatively damaged DNA: Liquid chromatography-tandem mass spectrometry analysis of urinary 8-oxo-7,8-dihydro-2'-deoxyguanosine -- Assessing sperm DNA fragmentation with the sperm chromatin dispersion test.
  • 2005 CRCnetBASE
    [edited by] Wolfram Siede, Yoke Wah Kow, Paul W. Doetsch.
  • 2009 Springer
    Kum Kum Khanna, Yosef Shiloh, editors.
    DNA Damage Sensing and Signaling / Daniel Durocher -- Signaling at Stalled Replication Forks / Daniel A. Mordes and David Cortez -- An Oncogene-Induced DNA Replication Stress Model for Cancer Development / Thanos D. Halazonetis -- Cellular Responses to Oxidative Stress / Inbal Dar and Ari Barzilai -- Cell Cycle Regulation and DNA Damage / Ryo Sakasai and Randal S. Tibbetts -- Chromatin Modifications Involved in the DNA Damage Response to Double Strand Breaks / Julia Pagan, Emma Bolderson, Mathew Jones and Kum Kum Khanna -- Telomere Metabolism and DNA Damage Response / Tej K. Pandita -- DNA Double Strand Break Repair: Mechanisms and Therapeutic Potential / Laura M. Williamson, Chris T. Williamson and Susan P. Lees-Miller -- DNA Base Excision Repair: A Recipe for Survival / Rabindra Roy and Sankar Mitra -- DNA Damage Tolerance and Translesion Synthesis / Alan R. Lehmann -- Nucleotide Excision Repair: from DNA Damage Processing to Human Disease / Mischa G. Vrouwe and Leon H.F. Mullenders -- Chromosomal Single-Strand Break Repair / Keith W. Caldecott -- Mouse Models of DNA Double Strand Break Repair Deficiency and Cancer / Sachin Katyal and Peter J. McKinnon -- Cancer Biomarkers Associated with Damage Response Genes / Anne E. Kiltie, Marie Fernet and Janet Hall -- Linking Human RecQ Helicases to DNA Damage Response and Aging / Wen-Hsing Cheng, Byungchan Ahn and Vilhelm A. Bohr -- Single-Stranded DNA Binding Proteins Involved in Genome Maintenance / Derek J. Richard and Kum Kum Khanna -- The Fanconi anemia-BRCA Pathway and Cancer / Toshiyasu Taniguchi -- BRCA1 and BRCA2: Role in the DNA Damage Response, Cancer Formation and Treatment / Kienan Savage and D. Paul Harkin.
  • 2013 Springer Protocols
    edited by Svetlana Makovets.
    DNA electrophoresis: historical and theoretical perspectives / Gareth A. Roberts and David T.F. Dryden -- Basic DNA electrophoresis in molecular cloning: a comprehensive guide for beginners / Svetlana Makovets -- Analysis of branched DNA replication and recombination intermediates from prokaryotic cells by two-dimensional (2D) native-native agarose gel electrophoresis / Nicholas P. Robinson -- Analysis of DNA structures from eukaryotic cells by two-dimensional native-native DNA agarose gel electrophoresis / Andreas S. Ivessa -- Directionality of replication fork movement determined by two-dimensional native-native DNA agarose gel electrophoresis / Andreas S. Ivessa -- Native/denaturing two-dimensional DNA electrophoresis and its application to the analysis of recombination intermediates / Jessica P. Lao, Shangming Tang, and Neil Hunter -- Plasmid DNA topology assayed by two-dimensional agarose gel electrophoresis / Jorge B. Schvartzman [and three others] -- A neutral glyoxal gel electrophoresis method for the detection and semi-quantitation of DNA single-strand breaks / Brian Pachkowski and Jun Nakamura -- Denaturing gradient gel electrophoresis (DGGE) / Fiona Strathdee and Andrew Free -- Polyacrylamide temperature gradient gel electrophoresis / Viktor Viglasky -- Separation of DNA oligonucleotides using denaturing urea PAGE / Fiona Flett and Heidrun Interthal -- Pulsed-field gel electrophoresis of bacterial chromosomes / Julia S.P. Mawer and David R.F. Leach -- Resolution of budding yeast chromosomes using pulsed-field gel electrophoresis / Aziz El Hage and Jonathan Houseley -- Analysis of DNA damage via single-cell electrophoresis / Diana Anderson and Julian Laubenthal -- Fluorescence in situ hybridization on electrophoresed cells to detect sequence specific DNA damage / Julian Laubenthal and Diana Anderson -- Analysis of DNA-protein interactions using PAGE: band-shift assays / Lynn Powell -- Assaying cooperativity of protein -- DNA interactions using agarose gel electrophoresis / Tanya L. Williams and Daniel L. Levy -- DNA bending by proteins: utilizing plasmid pBendAT as a tool / Fenfei Leng -- Using PCR coupled to PAGE for detection and semiquantitative evaluation of telomerase activity / Laura Gardano.
  • 2012 Springer Protocols
    edited by Antonio Alonso.
    An overview of DNA typing methods for human identification : past, present, and future / Robyn Thompson, Silvia Zoppis, and Bruce McCord -- Capillary electrophoresis and 5-channel LIF detection of a 26plex autosomal STR asay for human identification / Carolyn R. Hill -- Capillary electrophoresis of miniSTR markers to genotype highly degraded DNA samples / Michael D. Coble -- Interpretation guidelines of a standard Y-chromosome STR 17-plex PCR-CE assay for crime casework / Lutz Roewer and Maria Geppert -- Capillary electrophoresis of an X-chromosome STR decaplex for kinship deficiency cases / Leonor Gusmão [and others] -- A 48-plex autosomal SNP GenPlex Assay for human individualization and relationship testing / Carmen Tomas, Claus Børsting, and Niels Morling -- Typing of 49 autosomal SNPs by single base extension and capillary electrophoresis for forensic genetic testing / Claus Børsting, Carmen Tomas, and Niels Morling -- A 34-plex autosomal SNP single base extension assay for ancestry investigations / C. Phillips, M. Fondevila, and Maria Victoria Lareau -- SNaPshot® minisequencing analysis of multiple ancestry-informative Y-SNPs using capillary electrophoresis / Maria Geppert and Lutz Roewer -- Capillary electrophoresis of 38 noncoding biallelic mini-indels for degraded samples and as complementary tool in paternity testing / Rui Pereira and Leonor Gusmão -- Capillary electrophoresis of an 11-plex mtDNA coding region SNP single base extension assay for discrimination of themost common caucasian HV1/HV2 mitotype / Peter M. Vallone -- Capillary electrophoresis of a multiplex reverse transcription-polymerase chain reaction to target messenger RNA markers for body fluid identification / Cordula Haas, Erin Hanson, and Jack Ballantyne -- DNA extraction from aged skeletal samples for STR typing by capillary electrophoresis / René Huel [and others] -- Interpretation guidelines for multilocus STR forensic profiles from low template DNA samples / Zoran M. Budimlija and Theresa A. Caragine -- Interpretation guidelines for mixed-STR multilocus electrophoretic profiles / Juan Antonio Luque -- Capillary electrophoresis analysis of a 9-plex STR assay for canine genotyping / Barbara van Asch and António Amorim -- Capillary electrophoresis of DNA from Cannabis sativa for correlation of samples to geographic origin / Heather Mller Coyle -- Capillary electrophoresis of multigene barcoding chloroplast markers for species identification of botanical trace evidence / Gianmarco Ferri, Beatrice Corradini, and Milena Alù -- Capillary electrophoresis of big-dye terminator sequencing reactions for human mtDNA control region haplotyping in the identification of human remains / Marta Montesino and Lourdes Prieto -- Capillary electrophoresis of human mtDNA control region sequences from highly degraded samples using short mtDNA amplicons / Odile M. Loreille and Jodi A. Irwin -- Interpretation guidelines of mt DNA control region sequence electropherograms in forensic gnetics / Manuel Crespillo Marquez -- Capillary electrophoresis of mtDNA cytochrome b gene sequences for animal species identification / Adrian Linacre -- Sequence analysis of the canine mitochondrial DNA control region from shed hair samples in criminal investigations / C. Berger, B. Berger, and W. Parson -- Integrated sample cleanup and microchip capillary array electrophoresis for high-performance forensic STR profiling / Peng Liu [and others] -- Microchip capillary electrophoresis protocol to evaluate quality and quantity of mtDNA amplified fragments for DNA sequencing in forensic genetics / Coro Fernández and Antonio Alonso -- Microchip capillary electrophoresis of multi-locus VNTR analysis for genotyping of Bacillus anthracis and Yersinia pestis in microbial forensic cases / Andrea Ciammaruconi.
  • 2013 Springer
    Maria Spies, editor.
    Also available: Print – 2013
  • 2005 CRCnetBASE
    edited by Manel Esteller.
  • 2009 Springer Protocols
    edited by Jörg Tost.
    DNA methylation : an introduction to the biology and the disease-associated changes of a promising biomarker / Jörg Tost -- Quantification of global DNA methylation by capillary electophoresis and mass spectrometry / Maria Berdasco, Mrio F. Fraga, and Manel Esteller -- Methyl group acceptance assay for the determination of global DNA methylation levels / Kenneth P. Nephew, Curt Balch, and David G. Skalnik -- Immunodetection array / Johannes Pröll ... [et al.] -- Methylated DNA immunoprecipitation (MeDIP) / Fabio Mohn ... [et al.] -- The MIRA method for DNA methylation analysis / Tibor A. Rauch and Gerd P. Pfeifer -- The HELP assay / Mayumi Oda and John M. Greally -- Differential methylation hybridization : profiling DNA methylation with a high-density CpG island microarray / Pearlly S. Yan ... [et al.] -- Analysis of DNA methylation by amplification of intermethylated sites (AIMS) / Mireia Jordà ... [et al.] -- Methylation-sensitive representational difference analysis (MS-RDA) / Toshikazu Ushijima and Satoshi Yamashita -- Restriction landmark genomic scanning : analysis of CpG islands in genomes by 2D gel elctrophoresis / Joseph F. Costello ... [et al.] -- GoldenGate assay for DNA methylation profiling / Marina Bibikova and Jian-Bing Fan -- 5'-azacytidine expression arrays / Paul Cairns -- DNA methylation analysis by bisulfite conversion, cloning, and sequencing of individual clones / Yingying Zhang ... [et al.] -- Identification and quantification of differentially methylated loci by the Pyrosequencing technology / Emelyne Dejeux ... [et al.] -- Mass spectrometric analysis of cytosine methylation by base-specific cleavage and primer extension methods / Dirk van den Boom and Mathias Ehrich -- Melting curve assays for DNA methylation analysis / Tomasz K. Wojdacz and Alexander Dobrovic -- Methylatioin SNaPshot : a method for the quantification of site-specific DNA methylation levels / Zachary Kaminsky and Arturas Petronis -- Bio-COBRA : absolute quantification of DNA methylation in electrofluidics chips / Romulo Martin Brena and Christoph Plass -- Restriction digestion and real-time PCR (qAMP) / Christopher C. Oakes ... [et al.] -- MethylQuant : a real-time PCR-based method to quantify DNA methylation at single specific cytosines / Claire Dugast-Darzacq and Thierry Grange -- Methylation-specific PCR / Julien D.F. Licchesi and James G. Herman -- MethyLight / Mihaela Campan ... [et al.] -- Quantification of methylated DNA by HeavyMethyl duplex PCR / Jürgen Distler -- Analysis of methylated circulating DNA in cancer patients' blood / Eiji Sunami ... [et al.] -- Prevention of PCR cross-contamination by UNG treatment of bisulfite-treated DNA / Reimo Tetzner -- Profiling DNA methylation from small amounts of genomic DNA starting material : efficient sodium bisulfite conversion and subsequent whole-genome amplification / Jonathan Mill and Arturas Petronis.
  • 2005 Springer
    [edited by] Moshe Szyf.
    DNA methylation : three decades in search of function / Aharon Razin -- Epigenetic mechanisms of gene regulation : relationships between DNA methylation, histone modification, and chromatin structure / Keith D. Robertson -- DNA hypo- vs. hypermethylation in cancer : tumor specificity, tumor progression, and therapeutic implications / Melanie Ehrlich and Guanchao Jiang -- DNA methylation in urological cancers / Wolfgang A. Schulz and Hans-Helge Seifert -- DNA methylation in colorectal cancer / Jeremy R. Jass ... [et al.] -- CpG island hypermethylation of tumor suppressor genes in human cancer : concepts, methodologies and uses / Michel Herranz and Manel Esteller -- The loss of methyl groups in DNA of tumor cells and tissues : the immunochemical approach / Alain Niveleau ... [et al.] -- Identifying clinicopathological association of DNA hypermethylation in cancers using CpG island microarrays / Susan H. Wei ... [et al.] -- Methylation analysis in cancer : (epi)genomic fast track from discovery to clinical routine / Carolina Haefliger, Sabine Maier and Alexander Olek -- Regulation of DNA methyltransferases in cancer / Nancy Detich and Moshe Szyf -- Inhibition of poly(ADP-ribosyl)ation allows DNA hypermethylation / Anna Reale ... [et al.] -- The role of active demethylation in cancer and its therapeutic potential / Moshe Szyf ... [et al.] -- Purine analogues and their role in methylation and cancer chemotherapy / Katherine L. Seley and Sylvester L. Mosley -- DNA methyltransferase inhibitors : paving the way for epigenetic cancer therapeutics / Gregory K. Reid and A. Robert MacLeod -- Preclinical and clinical studies on 5-aza-2'-deoxycytidine, a potent inhibitor of DNA methylation, in cancer therapy / Richard L. Momparler -- Anticancer gene therapy by in vivo DNA electrotransfer of MBD2 antisense / Pascal Bigey and Daniel Scherman.
  • 2006 Springer
    W. Doerfler and P. Böhm, eds.
    Also available: Print – 2006
  • 2006 Springer
    W. Doerfler and P. Böhm (eds.).
    Regulation of chromatin and DNA-methylation patterns in blood cell development / C. Bonifer, P. Lefevre, and H. Tagoh -- Methylation dynamics in the early mammalian embryo : implications of genome reprogramming defects for development / T. Haaf -- Epigenetic regulation in drosophila / F. Lyko ... [et.al.] -- Epimutations in human disease / B. Horsthemke -- Epigenotypes of latent herpesvirus genomes / J. Minarovits -- Epigenetics of complex diseases : from general theory to laboratory experiments / A. Schumacher and A. Petronis -- MSL proteins and the regulation of gene expression / S. Rea and A. Akhtar -- DNA methylation profiles of female steroid hormone-driven human malignancies / M. Campan, D.J. Weisenberger, and P.W. Laird -- Genome-wide analysis of DNA methylation changes in human malignancies / C. Plass and D.J. Smiraglia -- Decreased fidelity in replicating DNA methylation patterns in cancer cells leads to dense methylation of a CpG island / N. Watanabe ... [et.al.] -- Methylation of endogenous human retroelements in health and disease / W. A. Schulz, C. Steinhoff, and A.R. Florl -- Cancer-linked DNA hypomethylation and its relationship to hypermethylation / M. Ehrlich.
    Also available: Print – 2006
  • 2005 Springer
    edited by Manel Esteller.
  • 2008 CRCnetBASE
    Sun-Chong Wang, Arturas Petronis.
  • 2011
    Yuya Kobayashi.
    Candidate gene based studies have identified a handful of aberrant CpG DNA methylation events in prostate cancer (Brooks et al. 1998; Yegnasubramanian et al. 2004). However, large scale DNA methylation profiles have not been examined for normal prostates or prostate tumors. Additionally, the mechanisms behind these DNA methylation alterations are unknown. In this thesis, I describe the results of my efforts to better understand these previously unexplored areas of biology. For the study presented in this thesis, I quantitatively profiled 95 primary prostate tumors and 86 healthy prostate tissue samples for their DNA methylation levels at 26,333 CpGs representing 14,104 gene promoters by using the Illumina HumanMethylation27 platform. When the profiles of the prostate tissue samples were compared, I observed a substantial number of tumor-specific DNA methylation alterations. A 2-class Significance Analysis of this dataset revealed 5,912 CpG sites with increased DNA methylation and 2,151 CpG sites with decreased DNA methylation in tumors (FDR < 0.8%). Prediction Analysis of this dataset identified 87 CpGs that are the most predictive diagnostic methylation biomarkers of prostate cancer. By integrating available clinical follow-up data, I also identified 69 prognostic DNA methylation alterations that correlate with biochemical recurrence of the tumor. To identify the mechanisms responsible for these genome-wide DNA methylation alterations, I measured the gene expression levels of several DNA methyltransferases (DNMTs) and their interacting proteins by TaqMan qPCR and observed increased expression of DNMT3A2, DNMT3B, and EZH2 in tumors. Subsequent transient transfection assays in cultured primary prostate cells revealed that DNMT3B1 and DNMT3B2 overexpression resulted in increased methylation of a substantial subset of CpG sites that also showed tumor-specific increased methylation.
  • 2006 CRCnetBASE
    edited by David B. Allison ... [et al.].
    Also available: Print – 2006
  • pt. A-B, 2006. ScienceDirect
    pt. B ScienceDirect
    edited by Alan Kimmel & Brian Oliver.
    Pt. A. Array platforms and wet-bench protocols -- pt. B. Databases and statistics.
    Also available: Print – pt. A-B, 2006.
  • 2011 Springer Protocols
    edited by Giampaolo Zuccheri and Bruno Samori.
    Synthesis and characterization of self-assembled DNA nanostructures / Chenxiang Lin [and others] -- Protocols for self-assembly and imaging of DNA nanostructures / Thomas L. Sobey and Friedrich C. Simmel -- Self-assembly of metal-DNA triangles and DNA nanotubes with synthetic junctions / Hua Yang [and others] -- DNA-templated Pd conductive metallic nanowires / Khoa Nguyen, Stephane Campidelli, and Arianna Filoramo -- Method to map spatiotemporal pH changes inside living cells using a pH-triggered DNA nanoswitch / Souvik Modi and Yamuna Krishnan -- Control of helical handedness in DNA and PNA nanostructures / Roberto Corradini [and others] -- G-quartet, G-quadruplex, and G-wire regulated by chemical stimuli / Daisuke Miyoshi and Naoki Sugimoto -- Preparation and atomic force microscopy of quadruplex DNA / James Vesenka -- Synthesis of long DNA-based nanowires / Alexander Kotlyar -- G-wire synthesis and modification with gold nanoparticle / Christian Leiterer, Andrea Csaki, and Wolfgang Fritzsche -- Preparation of DNA nanostructures with repetitive binding motifs by rolling circle amplification / Edda Rei⁷, Ralph Holzel, and Frank F. Bier -- Controlled confinement of DNA at the nanoscale : nanofabrication and surface bio-functionalization / Matteo Palma [and others] -- Templated assembly of DNA origami gold nanoparticle arrays on lithographically patterned surfaces / Albert M. Hung and Jennifer N. Cha -- DNA-modified single crystal and nanoporous silicon / Andrew Houlton [and others] -- Atomic force microscopy as a lithographic tool : nanografting of DNA nanostructures for biosensing applications / Matteo Castronovo and Denis Scaini -- Trapping and immobilization of DNA molecules between nanoelectrodes / Anton Kuzyk, J. Jussi Toppari, and Paivi Torma -- DNA contour length measurements as a tool for the structural analysis of DNA and nucleoprotein complexes / Claudio Rivetti -- DNA molecular handles for single-molecule protein-folding studies by optical tweezers / Ciro Cecconi [and others] -- Optimal practices for surface-tethered single molecule total internal reflection fluorescence resonance energy transfer analysis / Matt V. Fagerburg and Sanford H. Leuba -- Engineering mononucleosomes for single-pair FRET experiments / Wiepke J.A. Koopmans, Ruth Buning, and John van Noort -- Measuring DNA-protein binding affinity on a single molecule using optical tweezers / Micah J. McCauley and Mark C. Williams -- Modeling nanopores for sequencing DNA / Jeffrey R. Comer, David B. Wells, and Aleksei Aksimentiev.
  • 2011 Springer Protocols
    edited by Hideo Tsubouchi.
    Methods to study mitotic homologous recombination and genome stability / Xiuzhong Zheng, Anastasiya Epstein, and Hannah L. Klein -- Characterizing resection at random and unique chromosome double-strand breaks and telomere ends / Wenjian Ma [and others] -- Characterization of meiotic recombination initiation sites using pulsed-field gel electrophoresis / Sarah Farmer, Wing-Kit Leung, and Hideo Tsubouchi -- Genome-wide detection of meiotic DNA double-strand break hotspots using single-stranded DNA / Hannah G. Blitzblau and Andreas Hochwagen -- Detection of covalent DNA-bound Spo11 and topoisomerase complexes / Edgar Hartsuiker -- Molecular assays to investigate chromatin changes during DNA double-strand break repair in yeast / Scott Houghtaling, Toyoko Tsukuda, and Mary Ann Osley -- Analysis of meiotic recombination intermediates by two-dimensional gel electrophoresis / Jasvinder S. Ahuja and G. Valentin Borner -- Mapping of crossover sites using DNA microarrays / Stacy Y. Chen and Jennifer C. Fung -- Using the semi-synthetic epitope system to identify direct substrates of the meiosis-specific budding yeast kinase, Mek1 / Hsiao-Chi Lo and Nancy M. Hollingsworth -- Genetic and molecular analysis of mitotic recombination in Saccharomyces cerevisiae / Belen Gomez-Gonzalez, Jose F. Ruiz, and Andres Aguilera -- In vivo site-specific mutagenesis and gene collage using the delitto perfetto system in yeast Saccharomyces cerevisiae / Samantha Stuckey, Kuntal Mukherjee, and Francesca Storici -- Detection of RNA-templated double-strand break repair in yeast / Ying Shen and Francesca Storici -- SNP-Based Mapping of crossover recombination in Caenorhabditis elegans / Grace C. Bazan and Kenneth J. Hillers -- Characterization of meiotic crossovers in pollen from Arabidopsis thaliana / Jan Drouaud and Christine Mezard -- Isolation of meiotic recombinants from mouse sperm / Francesca Cole and Maria Jasin -- Homologous recombination assay for interstrand cross-link repair / Koji Nakanishi [and others] -- Evaluation of homologous recombinational repair in chicken B lymphoma cell line, DT40 / Hiroyuki Kitao, Seiki Hirano, and Minoru Takata -- Understanding the immunoglobulin locus specificity of hypermutation / Vera Batrak, Artem Blagodatski, and Jean-Marie Buerstedde -- Quality control of purified proteins involved in homologous recombination / Xiao-Ping Zhang and Wolf-Dietrich Heyer -- Assays for structure-selective DNA endonucleases / William D. Wright, Kirk T. Ehmsen, and Wolf-Dietrich Heyer -- In vitro assays for DNA pairing and recombination-associated DNA synthesis / Jie Liu, Jessica Sneeden, and Wolf-Dietrich Heyer -- In vitro assay for monitoring the formation and branch migration of holliday junctions mediated by a eukaryotic recombinase / Yasuto Murayama and Hiroshi Iwasaki -- Reconstituting the key steps of the DNA double-strand break repair in vitro / Matthew J. Rossi [and others] -- Biochemical studies on human Rad51-mediated homologous recombination / Youngho Kwon, Weixing Zhao, and Patrick Sung -- Studying DNA replication fork stability in xenopus egg extract / Yoshitami Hashimoto and Vincenzo Costanzo -- Supported lipid bilayers and DNA curtains for high-throughput single-molecule studies / Ilya J. Finkelstein and Eric C. Greene -- FRET-based assays to monitor DNA binding and annealing by Rad52 recombination mediator protein / Jill M. Grimme and Maria Spies -- Visualization of human Dmc1 presynaptic filaments / Michael G. Sehorn and Hilarie A. Sehorn -- Tracking of single and multiple genomic loci in living yeast cells / Imen Lassadi and Kerstin Bystricky -- Cell biology of homologous recombination in yeast / Nadine Eckert-Boulet, Rodney Rothstein, and Michael Lisby -- Live cell imaging of meiotic chromosome dynamics in yeast / Harry Scherthan and Caroline Adelfalk -- Chromosome structure and homologous chromosome association during meiotic prophase in Caenorhabditis elegans / Kentaro Nabeshima.
  • v. 1-<2>, 1981-<83>
    edited by Errol C. Friedberg and Philip C. Hanawalt.
    Status: Not Checked OutLane Catalog Record
  • 2006 Springer
    [edited by] Adayabalam S. Balajee.
    Human premature aging disorders and dysfunction of DNA repair / Byungchan Ahn and Vilhelm A. Bohr -- DNA repair aspects for RecQ helicase disorders / Takehisa Matsumoto -- Trichothiodystrophy: a disorder highlighting the crosstalk between DNA repair and transcription / Miria Stefanini -- Roles of the BRCA1 and BRCA2 breast cancer susceptibility proteins in DNA repair / Katrin Gudmundsdottir, Emily Witt and Alan Ashworth -- Radiosensitivity of cells derived from Down syndrome patients: is defective DNA repair involved? / Adayapalam T. Natarajan -- The Fanconi anemia/BRCA pathway: FANCD2 at the crossroad between repair and checkpoint responses to DNA damage / Massimo Bogliolo and Jordi Surrallés -- Is ataxia telangiectasia a result of impaired coordination between DNA repair and cell cycle checkpoint regulators? / Adayabalam S. Balajee and Charles R. Geard -- Mechanisms of DNA damage and repair in Alzheimer disease / V. Prakash Reddy ... [et al.] -- Orchestration of telomeres and DNA repair factors in mammalian cells: implications for cancer and ageing / M. Prakash Hande -- Defective solar protection in xeroderma pigmentosum and Cockayne syndrome patients / Colette ApRhys and Daniel Judge.
    Also available: Print – 2006
  • 2012 ScienceDirect
    2012 ClinicalKey
    edited by Mark R. Kelley.
    Introduction and overview of current targets: bench to clinic / Mark R. Kelley -- 2. MGMT a critical DNA repair gene target for chemotherapy resistance / Stanton L. Gerson and Lili Liu -- 3. Blockade of base excision repair: inhibition of small lesions results in big consequences to cancer cells / Melissa Fishel and Carlo Vascotto -- 4. PARP inhibitors -- scientific rationale and clinical development for cancer / Ruth Plummer, Nicola J. Curtin and Yvette Drew -- 5. Inhibiting selective DNA polymerases for therapeutic intervention / Anthony J. Berdis -- 6. Targeting the nucleotide excision repair pathway for therapeutic applications / John Turchi and Stephan M. Patrick -- 7. Homologous recombination and ATM/ATR targets / Henning Willers, Lee Zou and Heike N. Pfaffle -- 8. DNA double strand break repair by nonhomologous end joining and its clinical relevance / Michael Weinfeld and Susan Lees-Miller -- 9. Defective MMR-c-Abl-p73-GADD45alpha expression in cancer chemoresistance / David Boothman and Long Shan Li -- 10. DNA repair signaling targets / Susan Ashwell -- 11. Redox regulation of DNA repair and therapeutic / Millie M. Georgiadis -- 12. Personalized cancer medicine: DNA repair alterations is a promising predictive marker in cancer / Srinivasan Madhusudan -- 13. The role of DNA damage and repair in neurotoxicity caused by cancer therapies / Michael R. Vasko -- 14. Future directions with DNA repair inhibitors / Mark R. Kelley.
  • 2013 Springer
    Lesley A. Mathews, Stephanie M. Cabarcas, Elaine M. Hurt, editors.
    The existence of 'cancer stem cells' (CSCs) has been a topic of heated debate for the last few years within the field of cancer biology. Their continuous characterization in a variety of solid tumors has lead to an abundance of evidence supporting their existence. CSCs are believed to be responsible for resistance against conventional treatment regimes of chemotherapy and radiation, ultimately, leading to metastasis and patient demise. To help aid clinicians, pharmaceutical companies and academic labs investigating how to better kill these highly aggressive cells we have summarized the DNA repair mechanism(s) and their role in the maintenance and regulation of both normal and cancer stem cells. Our book represents a comprehensive investigation into the highly effective DNA repair mechanisms of CSCs and what we need to understand in order to develop more advanced therapies to eradicate them from patients. Currently, there are no other published works entirely on DNA repair and Cancer Stem Cells. In addition, our book provides a comprehensive overview of CSC isolation and characterization from a variety of solid tumor types.
  • pt. A-B, 2006. ScienceDirect
    pt. B ScienceDirect
    edited by Judith Campbell, Paul Modrich.
    Also available: Print – pt. A-B, 2006.
  • 2012 Springer Protocols
    edited by Lotte Bjergbæk.
    DNA repair : front and center and not going away! / Vilhelm A. Bohr -- Identification of genes required for damage survival using a cell-based RNAi screen against the Drosophila genome / Dashnamoorthy Ravi and Alexander James Roy Bishop -- Isolating genes involved with genotoxic drug response in the nematode Caenorhabditis elegans using genome-wide RNAi screening / Lone Vedel Schøler [and others] -- Establishment of the DNA repair-defective mutants in DT40 cells / Masamichi Ishiai, Emi Uchida, and Minoru Takata -- Electrophoretic mobility shift assays for protein-DNA complexes involved in DNA repair / Chun Tsai [and others] -- Comet assay : a sensitive genotoxicity test for the detection of DNA damage and repair / Günter Speit and Andreas Rothfuss -- Detection of DNA damage by comet fluorescence in situ hybridization / Wiebke Schlörmann and Michael Glei -- Quantitative DNA damage and repair measurement with the yeast comet assay / Rui Oliveira and Björn Johansson -- Analysis of DNA damage and repair in nuclear and mitochondrial DNA of animal cells using quantitative PCR / Amy M. Furda [and others] -- In vitro DNA mismatch repair in human cells / Liya Gu, Charles M. Ensor, and Guo-Min Li -- Eukaryotic DNA mismatch repair in vitro / Fenghua Yuan [and others] -- Immuno-slot blot assay for detection of UVR-mediated DNA damage / Mahsa Karbaschi [and others] -- Quantification of DNA photoproducts in mammalian cell DNA using radioimmunoassay / Thomas R. Berton and David L. Mitchell -- Measuring the formation and repair of UV damage at the DNA sequence level by ligation-mediated PCR / Ahmad Besaratinia and Gerd P. Pfeifer -- Construction of plasmids containing site-specific DNA interstrand cross-links for biochemical and cell biological studies / Milica Enoiu [and others] -- Replication-coupled DNA interstrand cross-link repair in Xenopus egg extracts / Puck Knipscheer [and others] -- In vitro base excision repair using mammalian cell extracts / Jason L. Parsons and Grigory L. Dianov -- Using Arabidopsis cell extracts to monitor repair of DNA base damage in vitro / Dolores Córdoba-Cañero, Teresa Roldán-Arjona, and Rafael R. Ariza -- In vitro monitoring of base excision repair in Saccharomyces cerevisiae / Simone Moertl and Fred Ahne -- Mitochondrial base excision repair assays / Ricardo Gredilla and Tinna Stevnsner -- O-hydroxylamine-coupled alkaline gel electrophoresis assay for the detection and measurement of DNA single-strand breaks / April M. Luke and Jun Nakamura -- DNA double-strand break damage and repair assessed by pulsed-field gel electrophoresis / Helen E. Bryant -- Quantitative amplification of single-stranded DNA / Eva-Maria Holstein and David Lydall -- Simple, non-radioactive measurement of single-stranded DNA at telomeric, sub-telomeric, and genomic loci in budding yeast / James M. Dewar and David Lydall -- Monitoring DNA recombination initiated by HO endonuclease / Neal Sugawara and James E. Haber -- Monitoring I-SceI-induced double-strand break repair in DT40 Cells / David du Plessis and Julian E. Sale -- I-SceI-based assays to examine distinct repair outcomes of mammalian chromosomal double strand breaks / Amanda Gunn and Jeremy M. Stark -- Studying repair of a single protein-bound nick in vivo using the Flp-nick system / Ida Nielsen, Anni H. Andersen, and Lotte Bjergbæk -- Measurement of diversification in the immunoglobulin light chain gene of DT40 cells / Julian E. Sale -- Live cell microscopy of DNA damage response in Saccharomyces cerevisiae / Sonia Silva [and others] -- Use of gene targeting to study recombination in mammalian cell DNA repair mutants / Jennifer J. Rahn, Gerald M. Adair, and Rodney S. Nairn -- In vitro rejoining of double strand breaks in genomic DNA / George Iliakis, Emil Mladenov, and Nge Cheong -- In vitro DNA double-strand break repair assay based on end-joining of defined duplex oligonucleotides / Kamal Datta [and others] -- Assays of bypass replication of genotoxic lesions in cell-free extracts / Nana Nikolaishvili-Feinberg and Marila Cordeiro-Stone -- Quantitative measurement of translesion DNA synthesis in mammalian cells / Omer Ziv [and others] -- Detection of PCNA modifications in Saccharomyces cerevisiae / Adelina A. Davies and Helle D. Ulrich -- In vitro PCNA modification assays / Joanne L. Parker and Helle D. Ulrich -- Analysis of inhibition of DNA replication in irradiated cells using the SV40 based in vitro assay of DNA replication / George Iliakis [and others] -- CHK1 kinase activity assay / Hong Yan Wang and Ya Wang -- Histone H2AX phosphorylation : a marker for DNA damage / Arishya Sharma, Kamini Singh, and Alexandru Almasan.

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A repository of medical knowledge from internal medicine, cardiology, genetics, pharmacy, diagnosis and management, basic sciences, patient care, and more.

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MicroMedex: Premier pharmaceutical information source containing multiple databases and drug reference tools. Of particular value is DRUGDEX Evaluations, one of the most comprehensive drug sources available.DynaMed is a clinical information resource used by physicians to answer clinical questions quickly and easily at the point of care. Topics are updated daily as new evidence becomes available.Scopus is the largest abstract and citation database of peer-reviewed literature: scientific journals, books and conference proceedings.A drug information resource containing: American Hospital Formulary System (AHFS), drug formulary for Lucile Packard Children's Hospital (LPCH) and Stanford Hospital & Clinics (SHC), Lexi-Drugs (adverse reactions, dosage and administration, mechanism of action, storage, use, and administration information), Lexi-Calc, Lexi-ID, Lexi-I.V. Compatibility (King Guide), Lexi-Interact, and Lexi-PALS.Cumulative Index to Nursing and Allied Health Literature (CINAHL) contains coverage of nursing and allied health literature.A knowledge database that provides access to topic reviews based on over 6000 clinically relevant articles. The evidence-based content, updated regularly, provides the latest practice guidelines in 59 medical specialtiesProvides critical assessments of systematic reviews compiled from a variety of medical journals.Selects from the biomedical literature original studies and systematic reviews that are immediately clinically relevant and then summarizes these articles in an enhanced abstract with expert commentary.

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In addition to covering Wiley and Springer, MyiLibrary is also the only provider for Oxford and Cambridge University Press titles. No seat restrictions.

A collection of biomedical books that can be searched directly by concept, and linked to terms in PubMed abstracts.

A web-based, decision support system for infectious diseases, epidemiology, microbiology and antimicrobial chemotherapy. The database, updated weekly, currently includes 337 diseases, 224 countries, 1,147 microbial taxa and 306 antibacterial (-fungal, -parasitic, -viral) agents and vaccines.

Over 10,000 notes outline the status of specific infections within each country.

Large number of high quality software and database programming titles from O'Reilly. Other software titles are also available from Sams and Prentice Hall. Limited to 7 concurrent users.Vast collection of software and database programming titles from multiple publishers, including Microsoft Press.Largest provider of engineering-related eBooks; includes titles in computer science and biomedical engineering.Over 4,000 full-text e-books covering scientific and technical information from CRC Press and others. Many handbooks and single volume reference sources.Includes peer-reviewed life science and biomedical research protocols compiled from Methods in Molecular Biology, Methods in Molecular Medicine, Methods in Biotechnology, Methods in Pharmacology and Toxicology, Neuromethods, the Biomethods Handbook, the Proteomics Handbook, and Springer Laboratory Manuals.Contains full text access to selected biomedical and nursing books.

Provides online, full-text access to Springer's journal titles as well as journals from other publishers.

Subjects include: life sciences, chemical sciences, environmental sciences, geosciences, computer science, mathematics, medicine, physics and astronomy, engineering and economics. Also includes eBooks.

Collection of over 8 thousand fulltext titles in engineering, math, and basic and applied biomedical research. Coverage is from 1967 to the present.A library of ebooks on a wide array of topics, digitized and made available online in conjunction with the original publishers.
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