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  • Neuronal dendritic trees are complex structures that endow the cell with powerful computing capabilities and allow for high neural interconnectivity. Studying the function of dendritic structures has a long tradition in theoretical neuroscience, starting with the pioneering work by Wilfrid Rall in the 1950s. Recent advances in experimental techniques allow us to study dendrites with a new perspective and in greater detail. The goal of this volume is to provide a rsum of the state-of-the-art in experimental, computational, and mathematical investigations into the functions of dendrites in a variety of neural systems. Thebook firstlooks at morphological properties of dendrites and summarizes the approaches to measure dendrite morphology quantitatively and to actually generate synthetic dendrite morphologies in computer models. This morphological characterization ranges from the study of fractal principles to describe dendrite topologies, to the consequences of optimization principles for dendrite shape. Individual approaches are collected to study the aspects of dendrite shape that relate directly to underlying circuit constraints and computation. The second main theme focuses on how dendrites contribute to the computations that neurons perform. What role do dendritic morphology andthe distributions of synapses and membrane properties over the dendritic tree have in determining the output of a neuron in response to its input? A wide range of studies is brought together, with topics ranging from general to system-specific phenomenasome having a strong experimental component, and others being fully theoretical. The studies come from many different neural systems and animal species ranging from invertebrates to mammals. With this broad focus, an overview is given of the diversity of mechanisms that dendrites can employ to shape neural computations.
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  • [Publisher-supplied data] Is our society color-blind? Trans-racial? Post-racial? And what if anything should this mean to professionals in clinical practice with diverse clients? The ambitious volume The Concept of Race and Psychotherapy probes these questions, compelling readers to look differently at their clients (and themselves), and offering a practical framework for more effective therapy. By tracing the racial folk taxonomies of eight cultures in the Americas and the Caribbean, the author elegantly defines race as a fluid construct, dependent on local social, political, and historical context for meaning but meaningless in the face of science. This innovative perspective informs the rest of the book, which addresses commonly held assumptions about problem behavior and the desire to change, and presents a social-science-based therapy model, applicable to a wide range of current approaches, that emphasizes both cultural patterns and client uniqueness. Among the highlights of the coverage: Common elements in therapy and healing across cultures.The psychological appeal of racial concepts despite scientific evidence to the contrary.Lessons psychology can learn from anthropology.Three types of therapeutic relationships, with strategies for working effectively in each.The phenomenon of discontinuous change in brief therapy.Solution-focused therapy from a cross-cultural perspective. Thought-provoking reading for psychologists, psychiatrists, clinical social workers, and other mental health professionals as well as graduate students in these fields, The Concept of Race and Psychotherapy affirms the individuality and the interconnectedness of every client.
  • The fundamentals : human rights and health -- Humanitarian medicine -- International, UN and WHO cooperation -- Disasters and conflicts -- Science, research and perspectives -- Society, health and equity.
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    Pharmacogenomics : past, present, and future / Martin M. Zdanowicz -- The genetic basis of pharmacogenomics / Taimour Y. Langaee, Jaekyu Shin -- Methodologies in pharmacogenomics / Christiana L. Aquilante -- The pharmacogenetics of drug metabolism / G. Scott Weston -- Pharmacogenomics and drug transport/efflux / Arthur G. Cox -- Pharmacodynamics and pharmacogenomics / Kathy D. Webster -- Cardiovascular disease / Kathryn M. Momary, Michael A. Crouch -- Hematology/oncology pharmacogenomics / Todd A. Thompson -- Central nervous system / Megan Jo Ehret -- Infectious diseases / Tawanda Gumbo, John D. Cleary -- Respiratory diseases / Emily Weidman-Evans, W. Greg Leader -- Toxicogenomics / Helen E. Smith -- The role of pharmacists in pharmacogenomics / Ajoy Koomer, Miriam A. Ansong -- Pharmacogenomics and clinical testing / James W. Fetterman, Jr., Pamela F. Hite -- Pharmacogenomics in pharmacy education / Ajoy Koomer -- Ethical considerations in pharmacogenomics / Sally A. Huston -- Future promise of pharmacogenomics in clinical practice / Jeffery D. Evans.
  • Metabolic alterations of cancer cells / Marco Sciacovelli, Edoardo Gaude, Mika Hilvo, and Christian Frezza -- Autophagy and cancer metabolism / Juliet Goldsmith, Beth Levine, and Jayanta Debnath -- Regulation of cancer metabolism by oncogenes and tumor suppressors / Raffaella Iurlaro, Clara Lucía León-Annicchiarico, and Cristina Muñoz-Pinedo -- Cross talk between cell death regulation and metabolism / Simone Fulda -- Techniques to monitor glycolysis / Tara TeSlaa and Michael A. Teitell -- Measurement of enolase activity in cell lysates / Keigo Fukano and Kazuhiro Kimura / Extracellular flux analysis to monitor glycolytic rates and mitochondrial oxygen consumption / Martin Pelletier, Leah K. Billingham, Madhu Ramaswamy, and Richard M. Siegel -- Conventional techniques to monitor mitochondrial oxygen consumption / Hélène Simonnet, Arnaud Vigneron, and Jacques Pouysségur -- Use of safranin for the assessment of mitochondrial membrane potential by high-resolution respirometry and fluorometry / Gerhard Krumschnabel, Andrea Eigentler, Mario Fasching, and Erich Gnaiger -- Kinetic analysis of local oxygenation and respiratory responses of mammalian cells using intracellular oxygen-sensitive probes and time-resolved fluorometry / Alexander V. Zhdanov, Ruslan I. Dmietriev, James Hynes, and Dmitri B. Papkovsky -- Cell-based measurements of mitochondrial function in human subjects / Ju-Gyeong Kang, Ping-yuan Wang, and Paul M. Hwang -- Use of chemical probes to detect mitochondrial ROS by flow cytometry and spectrofluorometry / Jing Chen and Clayton E. Mathews -- Methods to monitor ROS production by fluorescence microscopy and fluorometry / Aleksandra Wojtala, Massimo Bonora, Dominika Malinska, Paolo Pinton, Jerzy Duszynski, and Mariusz R. Wieckowski -- Genetically encoded redox sensor / Wai Kan Chiu, Atif Towheed, and Michael J. Palladino -- Use of genetically encoded sensors to monitor cytosolic ATP/ADP ratio in living cells / Andrei I. Tarasov and Guy A. Rutter -- Methods to monitor and compare mitochondrial and glycolytic ATP production / Simone Patergnani, Federica Baldassari, Elena De Marchi, Agnieszka Karkucinska-Wieckowska, Mariusz R. Wieckowski, and Paolo Pinton -- Measurement of ADP-ATP exchange in relation to mitochondrial transmembrane potential and oxygen consumption / Christos Chinopoulos, Gergely Kiss, Hibiki Kawamata, and Anatoly A. Starkov -- Real-time assessment of the metabolic profile of living cells with genetically encoded NADH sensors / Yuzheng Zhao, Yi Yang, and Joseph Loscalzo -- 13C isotope-assisted methods for quantifying glutamine metabolism in cancer cells / Jie Zhang, Woo Suk Ahn, Paulo A. Gameiro, Mark A. Keibler, Zhe Zhang, and Gregory Stephanopoulos -- Measurement of fatty acid oxidation rates in animal tissues and cell lines / Frank K. Huynh, Michelle F. Green, Timothy R. Koves, and Matthew D. Hirschey -- Methods to assess lipid accumulation in cancer cells / Jørgen Sikkeland, Yang Jin, and Fahri Saatcioglu -- Analysis of hypoxia-induced metabolic preprogramming / Chendong Yang, Lei Jiang, Huafeng Zhang, Larissa A. Shimoda, Ralph J. Bernardinis, and Gregg L. Semenza.
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    Physical examination of the cardiovascular system / Clarke G. Daniels, David V. Daniels, and Kamalendu Chatterjee -- Stress testing / Ian Brown and Donald Schreiber -- Chest pain and the acute coronary syndromes / David V. Daniels, Todd J. Brinton, and David P. Lee -- Cardiogenic shock / David V. Daniels, Todd J. Brinton, and Randall Vagelos -- Bradyarrhythmias and pacing / James V. Freeman and Paul J. Wang -- Wide and narrow complex tachyarrhythmias / David V. Daniels and Amin Al-Ahmad -- Sudden cardiac death and ICD therapy / David V. Daniels and Henry Hsia -- Atrial fibrillation / Anurag Gupta and Paul J. Wang -- Heart failure / David Kao, David V. Daniels, and Euan Ashley -- Pulmonary hypertension / François Haddad ... [et al.] -- Transplant medicine / Michael Pham -- Valvular diseases / Shriram Nallamshetty and Stanley G. Rockson -- Endocarditis / Todd L. Kiefer, Fred A. Lopez, and Randall Vagelos -- Pericardial disease / Todd L. Keifer and Randall Vagelos.
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  • This clinical guide is a concise up-to-date resource that covers a wide range of endodontic procedures, including non-surgical root canal therapy, surgical root canal therapy, trauma care and the management of fractured teeth, apexification, apexogenesis, revascularization, regeneration, Cvek partial pulpotomy, root canal retreatment, and periapical surgery. The provision of numerous flowcharts, checklists, and advice on error avoidance for each procedure will assist in decision-making in daily practice. Scientific and clinical evidence regarding the use and efficacy of the different forms of treatment is summarized, and helpful information is also presented on instrumentation. The inclusion of exam questions will assist those preparing for endodontic examinations. A Primer on Endodontic Treatment will be of value for dental students, residents in training to become endodontists, endodontists, pediatric dentists, and established dentists.
  • Basic Considerations -- Genitourinary System -- Digestive and Hepatobiliary System -- Endocrine System -- Soft Tissue Infection and Inflammation -- Respiratory System -- Skeletal System -- Cardiovascular System -- Central Nervous System -- Nuclear Oncology -- Therapeutic Applications of Nuclear Medicine.
  • General principles and philosophy -- Resources and strategy -- Common terms -- Combining multiple impairments -- General guidelines for impairment ratings -- Upper extremity -- Lower extremity -- Spine and pelvis -- Skin -- Complex regional pain syndrome, causalgia, reflex sympathetic dystrophy.
  • Concise Histology is the successor to the world-renowned Bloom and Fawcett's Textbook of Histology. This major new edition focuses on the core information and skills needed by students, and presents the essential elements of the body at the cellular, tissue and systematic levels. Highly illustrated in full color, the new edition has been fully updated throughout. The introductory chapter on cell biology has been substantially expanded and a new glossary has been added to help students with unfamiliar terminology. Each chapter contains a brief section on the histophysiology of each tissue and organ, and highlighted boxes identify the diseases resulting from the malfunctioning of specific cells. At the end of each chapter a series of questions allows students to test their knowledge. EM and microscopic level photographs have been digitally enhanced to provide optimum quality images. This new edition also comes with a free CD-ROM containing over 2000 questions and answers for self-assessment and 150 text-labelled images.
  • This pocket-sized manual serves as a concise and ideal reference work for therapeutic approaches using apheresis. Covering both basic theory and clinical details to facilitate improved treatment and patient outcomes, the text considers a variety of diseases, including myasthenia gravis, multiple sclerosis, Guillain-Barre syndrome, chronic inflammatory demyelinating polyneuropathy, nephrotic syndrome, TTP/TMA, dilated cardiomyopathy, and many other conditions. The book also reviews the growing trend toward adopting this unique therapy for a wide range of health management issues such as morbid obesity and/or type 2 diabetes, and for lowering LDL-cholesterol (cholesterol apheresis) in patients unresponsive to medication or lifestyle modification.
  • Concise pathology 1998 (3rd ed.).
  • Growing up with liver disease, psychological aspects of paediatric liver disease / H. Boulton, F. Bathgate -- Acute liver failure in children and adolescents / NP Shanmugam, S Bansal, A Dhawan -- Progressive familial intrahepatic cholestasis in children / AS Knisley -- Biliary atresia / R Hill, M Davenport -- Alagille Syndrome / M Mouzaki, BM Kamath -- Immune deficiency-related liver disease / N Hadzic -- Autoimmune liver disease / G Mielli-Vergani, D Vergani -- Wilson Disease / P Socha -- Non-alcoholic fatty liver disease in children / A Alisi, R De Vito, D Viggiano, L Morcaldi, V Nobili -- Non-cirrhotic portal hypertension / SK Yachha, B Jagadisan -- Primary liver malignancies: surgical aspects including transplantation / J-B Otte -- Viral hepatitis in children / X Stephene, E Sokal -- Non-viral infections of the liver / A Verma -- Intestinal failure, parenteral nutrition and liver disease / OJ Goulet -- Liver transplantation / R Ciria, N Heaton -- Hepatocyte transplantation, 'omics' and gene therapy in the management of liver diseases / S Jitraruch, H Qin, RD Hughes, SC Lehec, RR Mitry.
  • Concussion 2014
    Cerebral concussion : a historical perspective / Maroon, J.C -- Biomechanics of concussion / B.D. Stemper, F.A. Pintar -- The neurophysiology of concussion / D.A. Hovda -- Chronic traumatic encephalopathy / B. Omalu -- Cumulative effects of repetitive mild traumatic brain injury / J.E. Bailes, M.L. Dashnaw, A.L. Petraglia, R.C. Turner -- Understanding concussive injuries using investigational imaging methods / L.C. Henry -- Neurometabolic, electrophysiological, and imaging abnormalities / E. Chamard, M. Lassonde, H. Théoret -- Detection of white matter injury in concussion using high-definition fiber tractography / S.S. Shin, S. Pathak, N. Presson, W. Bird, L. Wagener, W. Schneider, D.O. Okonkwo, J.C. Fernandez-Miranda -- Magnetoencephalography in the diagnosis of concussion / R.R. Lee, M. Huang -- Evidence-based management of sport-related concussion / M. McCrea, K. Guskiewicz -- In-office management of sport-related concussion / E. Reynolds, M.W. Collins -- Treating prolonged symptoms of mild traumatic brain injury : neuropharmacology / K. Lercher, C. Camiolo Reddy -- Rehabilitation from postconcussion syndrome : nonpharmacological treatment / A.L. Nelson Sheese, T.A. Hammeke -- Concussion in ice hockey / C.M. Bonfield, D.A. Wecht, L.D. Lunsford -- Management of concussion in the professional football player / E.M. Pieroth, C. Hanks -- Developing an interdisciplinary community-based sports concussion management program / A. LoGalbo, C.M. Salinas, M. Dougherty, M. Field -- The multidisciplinary concussion management program / D.M. Panczykowski, J.E. Pardini -- Vulnerability in speed of visuomotor ability / A.B. Shuttleworth-Edwards, S.E. Radloff, V.J. Whitefield-Alexander -- Detecting eye movement abnormalities from concussion / J. Maruta, J. Ghajar -- Neurodegenerative changes after mild traumatic brain injury / S. Fakhran, L. Alhilali -- Future directions in brain injury research / T.A. Gennarelli.
  • Consequences of Ignorance and Arrogance for Mismanagement of Sports-Related Concussions: Short- and Long-Term Complications -- Neuropsychological Testing in Sports Concussion Management: An Evidence-Based Model when Baseline Is Unavailable -- Feasibility of Virtual Reality for Assessment of Neurocognitive, Executive, and Motor Functions in Concussion -- Feasibility of Electroencephalography for Direct Assessment of Concussion -- The Relevance of Assessing Cerebral Metabolic Recovery for a Safe Return to Play Following Concussion -- The Biomechanics of Concussion: 60 Years of Experimental Research -- Acute and Lingering Impairments in Post-concussion Postural Control -- Biomechanical Studies of Impact and Helmet Protection -- Neuropathology of Mild Traumatic Brain Injury: Relationship to Structural Neuroimaging Findings -- Metabolic Dysfunction Following Traumatic Brain Injury -- Advanced Neuroimaging of Mild Traumatic Brain Injury -- Biomarkers for Concussion -- Functional Magnetic Resonance Imaging in Mild Traumatic Brain Injury -- Predicting Postconcussive Symptoms After Mild Traumatic Brain Injury in Children and Adolescents -- Long-Term Effects of Pediatric Mild Traumatic Brain Injury -- Neuropsychological Assessment of Sports-Related Concussion: Pediatric Challenges -- Management of Collegiate Sport-Related Concussions -- Sports-Related Subconcussive Head Trauma -- The Role of the Quantitative EEG in the Diagnosis and Rehabilitation of the Traumatic Brain Injured Patients -- Current Understanding of Concussion: Treatment Perspectives -- Post-concussion Syndrome, Persistent Symptomatic Concussion, Related Sequelae, and Treatment of Mild Closed Head Injury.
  • "Continuing the tradition of the bestselling first edition, this second edition provides comprehensive coverage of neurobehavioral disorders in children and adults following impact and acceleration accidents. Completely revised and updated, the book includes comprehensive coverage of consciousness including normal, acute, and persistent alterations. Drawing on his training, education, and experience in human physiology, neuroanatomy, and endocrinology, the author not only gives readers a solid foundation for understanding, diagnosing, and treating concussive brain trauma, but also gives them tools to increase standards of care"--Provided by publisher.
  • Conditional somatic mutagenesis in the mouse using site-specific recombinases -- Cre/loxP-mediated chromosome engineering of the mouse genome -- Tetracycline-controlled genetic switches -- Novel gene switches -- Improved embryonic stem cell technologies -- Gene trap mutagenesis -- RNA interference in mice -- Viral vectors: a wide range of choices and high levels of service -- Conditional mutagenesis by cell-permeable proteins: potential, limitations and prospects -- Analysis of mouse development with conditional mutagenesis -- Conditional mouse models of cancer -- Conditional mutagenesis reveals immunological functions of widely expressed genes: activation thresholds, homeostatic mechanisms and disease models -- Conditional transgenesis and recombination to study the molecular mechanisms of brain plasticity and memory -- A novel conditional knockout strategy applied to serotonin receptors -- Conditional mouse models for Friedreich Ataxia, a neurodegenerative disorder associating cardiomyopathy -- Animal models in cardiovascular diseases: new insights from conditional models -- Conditional animal models for the study of lipid metabolism and lipid disorders -- Conditional mouse models to study developmental and pathophysiological gene function in muscle -- Analysis of calcuim channels by conditional mutagenesis -- Conditional mutagenesis of G-protein coupled receptors and G-proteins -- Contribution of targeted conditional somatic mutagenesis to deciphering retinoid X receptor functions and to generating mouse models of human diseases.
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    Prologue: The dangerous difference (1778-1954) -- Bk. 1. The sanction of the victim (1954-1969) -- Bk. 2. Interrogations (1969-1975) -- Bk. 3. Trials (1975-1976) -- Bk. 4. The family (1977-1980) -- Bk. 5. Lesbian vampires of Bavaria (1981-1985) -- Bk. 6. HOMOVAC (1986-1990) -- Epilogue: Promises to keep.
  • History of X-ray computed tomography / Jiang Hsieh -- Acquisition of projection images / Wei Zhao and Jeffrey H. Siewerdsen -- Reconstruction algorithms / Liang Li, Zhiqiang Chen, and Ge Wang -- Cone beam CT image quality / Jeffrey H. Siewerdsen, Wojciech Zbijewski, and Jennifer Xu -- Radiation dose / Ioannis Sechopoulos -- Image simulation / acovos Kyprianou, Andreu Badal, S. Gu, and Aldo Badano -- 3D image processing, analysis, and visualization / Kenneth R. Hoffmann, Peter B. Noël, and Martin Fiebich -- Volume-of-interest imaging / Chris C. Shaw -- Four-dimensional cone beam computed tomography / Tinsu Pan -- Image corrections for scattered radiation / Cem Altunbas -- Multidetector row CT / Xiangyang Tang -- Cone beam micro-CT for small-animal research / Erik L. Ritman -- Cardiac imaging / Katsuyuki (Ken) Taguchi and Elliot K. Fishman -- C-ARM CT in the interventional suite : current status and future directions / Rebecca Fahrig, Jared Starman, Erin Girard, Amin Al-Ahmad, Hewei Gao, Nishita Kothary, and Arundhuti Ganguly -- Cone beam CT : transforming radiation treatment guidance, planning, and monitoring / John W. Wong, David A. Jaffray, Jeffrey H. Siewerdsen, and Di Yan -- Breast CT / Stephen J. Glick.
  • Cone beam computed tomography (CBCT) has become the standard of reference in dental imaging. The distribution of CBCT devices is increasingly wide, and the number of required examinations is constantly growing. In this setting, it is now essential that medical and technical staff receive specific training in the use of CBCT and that technical guidelines for CBCT examinations are established. This clearly structured book on CBCT will be an ideal aid in daily clinical practice. It clearly explains basic CBCT anatomy, examination technique, and the use of 3D reformatting software. A wide range of cases are presented, covering the most frequent and relevant conditions and pathologies, including dental anomalies, inflammatory and degenerative disease, tumors, and implants.
  • Cone Beam CT of the Head and Neck' presents normal anatomy of the head using photographs of cadavers and CBCT images in sagittal, axial and coronal planes with the anatomic structures and landmarks clearly labelled. Important structures and regions are presented in detailed view. This is the first book with photographs of human tissue (based on slicing of cadaveric heads) combined with CBCT images.
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  • Conflict and Catastrophe Medicine: A Practical Guide 3e follows its successful predecessors in providing a framework for use by health professionals visiting a resource-constrained environment. Aimed at health professionals, Conflict and Catastrophe Medicine: A Practical Guide 3e encompasses problems brought about by local conflict or natural disasters. Itcovers preparation, organisation, logistics, treatment of major trauma and medical emergencies, and the special problems of delivering medicine in a hostile environment. This book will provide the reader with a mix of theory, opinion and practical advice to guide him through areas of conflicts, catastrophes and remote locations.
  • The Hungarian congenital abnormality registry (HCAR) -- Certain infectious and parasitic diseases -- Neoplasms -- Diseases of the blood and blood-forming organs -- Endocrine, nutritional and metabolic diseases -- Mental and behavioural disorders -- Diseases of the nervous system -- Diseases of the eye and adnexa -- Diseases of the ear and the mastoid process -- Diseases of the circulatory system -- Diseases of the respiratory system -- Diseases of the digestive system -- Diseases of the skin and subcutaneous tissue -- Diseases of the musculoskeletal system and connective tissue -- Diseases of the urinary tract -- Diseases of the genital organs -- Pregnancy, childbirth, and the puerperium -- Congenital malformations, deformations, and chromosomal abnormalities -- Association of maternal diseases during pregnancy with higher risk of congenital abnormalities (CAs) in their children -- Associations of maternal diseases with higher risk for preterm birth (PB) and low birth weight (LBW) newborns.
  • Written by leading experts in the fields of pediatrics, orthopedic surgery, and plastic and reconstructive hand surgery, Congenital Anomalies of the Upper Extremity encompasses the current knowledge of genetic and molecular causes of, and surgical and non-surgical treatment for, deformities of the hand. The book covers the many variations of congenital anomaly encountered in the clinical setting. Embryology, classification, incidence, and anesthesia considerations are discussed first, followed by physical medicine, rehabilitation and therapy management, including psychological considerations, for children living with these conditions. Failures of formation and differentiation of the fingers and hand plate, duplication, and overgrowth, as well as other generalized anomalies, are then presented in detail, including symbrachydactyly, syndactyly, Apert syndrome, polydactyly, amniotic band syndrome, and Madelung deformity, among others. Complete with plentiful photographs and illustrations to guide the clinician in preparing for and performing the necessary treatments, this is an essential book for hand surgeons, orthopedists and plastic surgeons.
  • Congenital cytomegalovirus (CMV) infection is the most common intrauterine transmitted viral infection, with a tremendous impact on fetuses and newborns. In this book the history of this disease, its pathophysiological background, epidemiology and symptoms, as well as diagnostic and therapeutic strategies, will be discussed. Since economic aspects are gaining more and more importance in health politics, one chapter is dedicated to this issue in the context of congenital CMV infection. The content is based on the latest scientific findings and written in an understandable manner, allowing persons not working in the field of congenital CMV to also profit from it. Thus, this book is of interest for medical doctors, nurses, midwives, economists, but also for men and women who want to inform themselves about this topic.
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    The fetal circulation -- Perinatal and postnatal changes in the circulation -- Oxygen uptake and delivery -- Functional assessment -- Prenatal and postnatal pulmonary circulation -- The ductus arteriosus and persistent patency of the ductus arteriosus -- Ventricular septal defect -- Atrial septal defect : partial anomalous drainage of pulmonary veins -- Atrioventricular septal defect -- Bicuspid aortic valve and aortic stenosis -- Aortic atresia, mitral atresia, and hypoplastic left ventricle -- Aortic arch obstruction -- Total anomalous pulmonary venous connection -- Pulmonary stenosis and atresia with ventricular septal defect (tetralogy of Fallot) -- Pulmonary stenosis and atresia with intact ventricular septum -- Tricuspid atresia and hypoplastic right ventricle -- Ebstein malformation of the tricuspid valve -- Aortopulmonary transposition -- Truncus arteriosus communis.
  • Genomic approaches in genetic research for endocrine diseases / Ravazzolo, R. -- Genetic defects of the growth-hormone-IGF axis associated with growth hormone insensitivity / Woods, K. -- Late effects of disturbed IGF signaling in congenital diseases: intrauterine and postnatal growth retardation / Cianfarani, S. ... [et al.] -- Growth hormone receptor polymorphisms: controversies and outcome of growth hormone treatment / Buzi, F. ... [et al.] -- Genetic disorders involving adrenal development / Lin, L., Ferraz-de-Souza, B., Achermann, J.C. -- Early management and gender assignment in disorders of sexual differentiation / Hughes, I.A -- Prenatal and early postnatal treatment of congenital adrenal hyperplasia / Ghizzoni, L. ... [et al.] -- Neonatal diabetes: the role of KCNJ11 (Kir6.2) / Tammaro, P. -- Diagnosis of neonatal and infancy-onset diabetes / Barbetti, F. -- Management of neonatal and infancy-onset diabetes mellitus / Søvik, O. ... [et al.] -- Insights in congenital hyperinsulinism / Hussain, K. -- A clinical approach to severe insulin resistance / Savage, D.B. ... [et al.] -- Inherited endocrine diseases involving G proteins and G protein-coupled receptors / Spiegel, A.M. -- Stem cells: from animal research to clinical applications / Redi, C.A. ... [et al.].
  • Physicians often have only partial knowledge of common congenital hand and upper extremity anomalies and their associated syndromes. Surgeons typically find these syndromes to be abstruse, and congenital hand conditions can represent an enigma even to pediatric geneticists. This book is designed to serve as a practical, up-to-date reference that will enable practitioners and students in a variety of disciplines to easily recognize the most common congenital upper extremity anomalies and syndromes. In total, 37 congenital upper extremity anomalies and 127 syndromes are discussed. Salient and common presenting features are described in detail and illustrated with the aid of high-quality digital color photographs whenever possible. In addition, relevant background information is included on such aspects as prevalence, etiology, pathogenesis, and findings elsewhere in the body.
  • Introduction to CT scan and MRI; Anomalous systemic venous connections; Anomalous pulmonary venous connections; Atrial septal defect; Unroofed coronary sinus; Atrioventricular septal defect; Ventricular septal defect; Tetralogy of Fallot; Tetralogy of Fallot with absent pulmonary valve; Pulmonary atresia with intact ventricular septum; Ebstein's anomaly; Patent ductus arteriosus; Left ventricular outflow tract obstruction; Aortic coarctation; Aortic arch interruption; Complete transposition of the great arteries; Hypoplastic left heart syndrome; Cor triatriatrum; Tricuspid atresia.
  • Historical perspective / Joseph K. Perloff -- National and international scope / Joseph K. Perloff, Amy Verstappen -- Specialized facilities for adults with congenital heart disease / Joseph K. Perloff, Pamela D. Miner, Linda Houser -- Survival patterns without cardiac surgery or interventional catheterization : a narrowing base / Joseph K. Perloff -- Survival patterns after cardiac surgery or interventional catherterization : a broadening base / Joseph K. Perloff, Mark D. Plunkett -- Echocardiography in anatomic imaging and hemodynamic evaluation of adults with congenital heart disease / John S. Child -- Cardiac magnetic resonance imaging and computed tomography in the assessment of adult congenital heart disease / Jamil Aboulhosn, Howard Dinh, John P. Finn -- Infective endocarditis and congenital heart disease / John S. Child, David A. Pegues, Joseph K. Perloff -- Management of pregnancy and contraception in congenital heart disease / John S. Child, Koseph K. Perloff, Brian Koos -- Genetics, epidemiology, and counseling / Fabian Chen, Emmanuèle Délot, Joseph K. Perloff -- Exercise and athletics in adults with congenital heart disease / Jamil Aboulhosn, Joseph K. Perloff -- Cyanotic congenital heart disease : a multisystem disorder / Joseph K. Perloff -- Psychiatric and psychosocial disorders in congenital heart disease / Barry H. Guze, Elisa A. Moreno, Joseph K. Perloff -- Neurological disorders / Joseph K. Perloff, Jerffrey L. Saver -- Cardiac surgery in adults with congenital heart disease : Operation and reoperation / Daniel Marelli ... [et al.] -- Prosthetic materials : selection, use, and long-term effects / Mark D. Plunkett, Joseph K. Perloff -- Cardiac transplantation in patients with congenital heart disease / Jon A. Kobashigawa, Daniel Marelli -- Transcatheter interventions in adults with congenital heart disease / Jamil Aboulhosn, Daniel Levi, John W. Moore -- Noncardiac surgery / Joseph K. Perloff, Michael Sopher -- Residua and sequelae : a perspective / Joseph K. Perloff -- Residua and sequelae involving cardiac valves / Joseph K. Perloff, Mark D. Plunkett -- Electrophysiologic abnormalities : unoperated occurrence and postoperative residua and sequelae / Kalyanam Shivkumar, Joseph K. Perloff -- Myocardial growth and the development and regression of increased ventricular mass / Joseph K. Perloff.
  • This book comprehensively covers the latest information about ventricular?vascular morphology and function in congenital heart disease (CHD) assessed by various innovative methodologies. Anatomical (morphological) abnormalities in CHD are generally accompanied with abnormal loading conditions, which, in turn, cause ventricular and vascular functional impairments. The functional impairments may also exist independently of the anatomical abnormalities. These two (morphological and functional abnormalities) importantly interact to determine underlying pathophysiology and generate clinical symptoms in CHD. Therefore, detailed and precise assessment of morphology and function is essential to better understand and treat this disease. Recent advances in technology have provided useful tools for this purpose, and novel findings are accumulating. The information contained here will provide researchers and clinicians with invaluable knowledge in this field.
  • Genetics of cardiac septation defects and their pre-implantation diagnosis / Deborah A. McDermott, Craig T. Basson, and Cathy J. Hatcher -- Molecular and genetic aspects of DiGeorge/velocardiofacial syndrome / Deborah A. Driscoll -- Mutation screening for the genes causing cardiac arrhythmias / Jeffrey A. Towbin -- Mutation analysis of the FBN1 gene in patients with Marfan syndrome / Paul Coucke, Petra Van Acker, and Anne De Paepe -- Mutation analysis of PTPN11 in Noonan syndrome by WAVE / Navaratnam Elanko and Steve Jeffery -- Williams-Beuren syndrome diagnosis using fluorescence in situ hybridization / Lucy R. Osborne, Ann M. Joseph-George, and Stephen W. Scherer -- Congenital heart disease: molecular diagnostics of supravalvular aortic stenosis / May Tassabehji and Zsolt Urban -- "Chip"ping away at heart failure / J. David Barrans and Choong-Chin Liew -- Molecular diagnostics of catecholaminergic polymorphic ventricular tachycardia using denaturing high-perfomance liquid chromatography and sequencing / Alex V. Postma, Zahurul A. Bhuiyan, and Hennie Bikker -- Mutation detection in tumor suppressor genes using archival tissue specimens / Aristotelis Astrinidis and Elizabeth Petri Henske -- Friedreich ataxia: detection of GAA repeat expansions and frataxin point mutations / Massimo Pandolfo -- The cardiovascular manifestations of Alagille syndrome and JAG1 mutations / Elizabeth Goldmuntz, Elizabeth Moore, and Nancy B. Spinner -- Array analysis applied to malformed hearts: molecular dissection of tetralogy of Fallot / Silke Sperling -- DNA mutation analysis in heterotaxy / Stephanie M. Ware -- Use of denaturing high-performance liquid chromatography to detect mutations in pediatric cardiomyopathies / Amy J. Sehnert.
  • Congenital hip disease (CHD) is the main cause of secondary osteoarthritis (OA) of the hip in young adults, which accounts for almost 40% of all cases of hip OA. Total hip replacement (THR) performed using optimal techniques can achieve a radical improvement in the quality of life of adult patients. This book offers in-depth coverage of all aspects of CHD in adults and its treatment. Relevant information is first provided on the basic anatomy of the hip and OA of the hip and on the classification, epidemiology, and natural history of CHD. The now limited role of femoral and pelvic osteotomies is carefully evaluated, and the use of THR is then considered in detail. Indications and preoperative planning are discussed, and the available operative techniques, analyzed. Clear guidance is provided on overcoming major technical difficulties, and the benefits of particular approaches and techniques are highlighted. More than 180 images and numerous case studies complement this reader-friendly text. The book will be an invaluable tool for orthopedic surgeons, rheumatologists and radiologists.
  • Congenital Malformations of the Head and Neck offers a unique conceptual and visual approach to children with congenital malformations of the head and neck. Developed by renowned leaders in the field, this title is richly illustrated with a wealth of patient photos, radiology and endoscopic images of malformations. Starting with the genetics of common congenital syndromes, Congenital Malformations of the Head and Neck goes on to comprehensively cover malformations of the ear, nose, nasopharynx, oral cavity, oropharynx, cleft lip and palate, larynx, trachea, and neck. Easy-to-read and an indispensable reference and teaching resource, this title will serve as an invaluable reference for clinicians, neurologists, pediatricians, otolaryngologists and head and neck surgeons. It should also be of great interest to fellows and residents.
  • Introduction -- Deformities of the anterior thoracic wall -- Diagnostics -- Aspects of indication setting for selection of individual therapy and informed consent -- Therapy -- Special techniques in the funnel chest deformity -- Special techniques in the keel chest deformity -- Special techniques in pectus arcuatum and mixed deformities -- Special aspects in females -- Special technique in the Poland syndrome -- Surgery of other congenital anomalies of the anterior thoracic wall -- Complications, special problems -- Actual technical improvements, future aspects -- Final conclusions.
  • Conductive polymers as organic nanometals -- Conducting polymer fibre for smart fabric and interactive textile applications -- Inkjet printing and patterning of PEDOT-PSS -- Printing organic electronics on flexible substrates -- Light emitting polymers -- Organic electro-optic materials -- Conjugated polymer electronics -- Electrical bistable polymer films and their applications in memory devices -- Electroactive polymers for batteries and supercapacitors -- Conjugated polymer based photovoltaic devices -- Biomedical applications of ICPs -- Biosensors based on conducting electroactive polymers -- Optical biosensors based on conjugated polymers -- Conducting polymers for MEMS and other micro-devices -- Corrosion protection using conducting polymers -- Artificial muscles.
  • To cope with the steadily growing body of knowledge and for organizational reasons the articles in this book are focussed on the modifiers ubiquitin, SUMO1/2/3, NED 8, ISG15 and FAT10 but it should be at least mentioned here that enzymes involved in conjugation and deconjugation of URM1, UFM1, ATG8 and ATG12 have been reported and continue to be investigated.
  • Conn's Current therapy latest editions only
  • Connected hippocampus 2015
    1. If I had a million neurons: potential tests of cortico-hippocampal theories -- 2. Diluted connectivity in pattern association networks facilitates the recall of information from the hippocampus to the neocortex -- 3. Cortico-hippocampal systems involved in memory and cognition: the PMAT framework -- 4. The subiculum: the heart of the extended hippocampal system -- 5. The neural correlates of navigation beyond the hippocampus -- 6. Septo-hippocampal signal processing: breaking the code -- 7. Major diencephalic inputs to the hippocampus: supramammillary nucleus and nucleus reuniens. Circuitry and function -- 8. Importance of the ventral midline thalmas in driving hippocampal functions -- 9. The mammillary bodies and memory: more than a hippocampal relay -- 10. Modulating the map: dopaminergic tuning of hippocampal spatial coding and interactions -- 11. Integrative hippocampal and decision-making neurocircuitry during goal-relevant predictions and encoding -- Index.
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    Currently, the ethics infrastructure -- from medical and scientific training to the scrutiny of ethics committees -- focuses on trying to reform informed consent to do a job which it is simply not capable of doing. Consent, or choice, is not an effective ethical tool in public ethics and is particularly problematic in the governance of genetics. Heather Widdows suggests using alternative and additional ethical tools and argues that if individuals are to flourish it is necessary to recognise and respect communal and public goods as well as individual goods. To do this she suggests a two-step process -- the 'ethical toolbox'. First the harms and goods of the particular situation are assessed and then appropriate practices are put in place to protect goods and prevent harms. This debate speaks to core concerns of contemporary public ethics and suggests a means to identify and prioritise public and common goods. -- [Publisher-supplied data]
  • Chapter 1. Peculiarities of connective tissue histophysiology, biochemistry and molecular biology -- Chapter 2. Cellular elements of connective tissue -- Chapter 3. Extracellular matrix of connective tissue. Histophysiology, biochemistry and molecular biology -- Chapter 4. Regulation of connective tissue metabolic functions -- Chapter 5. Biochemical and molecular mechanisms and manifestations of connective tissue ageing -- Chapter 6. Bone : an organ of the support and locomotor apparatus containing all types of connective tissue -- Chapter 7. Cartilage-cartilaginous tissue : structural, biochemical and molecular biological characteristics -- Chapter 8. Bone tissue : the structural-functional, biochemical and biomolecular characteristics of its components -- Chapter 9. Biochemical characteristics of synovial membrane and synovia -- Chapter 10. Molecular biological and biochemical regularities of connective tissue structures ontogenesis.
  • "In 1929 Germany, physiotherapist Elisabeth Dicke suffered from poor circulation in her right leg, acute back pain, and a host of other ailments. With no medical options offered beyond amputation of the leg, she turned to her own training for help. She began to massage the skin and subcutaneous fascia of the sacral bone and pelvic crest with pulling strokes. After several applications, she experienced less back pain, increased circulation to the leg, and within three months, disappearance of all symptoms. This was the beginning of Dickes systematic, scientifically based treatment method of connective tissue massage (or Bindegewebsmassage), now in wide use throughout the world. In this book, practitioners will get the first detailed, how-to description of connective tissue massage (CTM) {in the English language} including the principles, knowledge, and skills to implement it. Special Features: Begins with the origin and practical benefits of CTM, including its neuroanatomical and neurophysiological basis, Explores the relationship between the sensory, motor, and autonomic nervous systems and the complex reflex mechanisms that are activated by CTM therapy, Describes and illustrates specific stroking techniques that trigger the appropriate neural reflexes in every body segment, Shows how to make a diagnostic assessment based on skin, connective tissue, and muscle zones, Covers the full range of orthopedic, neurological, internal medicine, and gynecologic disorders that can be effectively treated with CTM. Complete with treatment plans, indications and contraindications, and modern medical guidelines, this book is essential for all physical and massage therapists and osteopaths who want to successfully integrate CTM into their practices. It is also a fascinating reference for physicians and other medical professionals who are interested in learning more about this important manual technique." --Provided by publisher.
  • Communication in the immune system by connexin channels / E. Oviedo-Orta and W. Howard Evans -- Gap junctions and connexins in the hematopoietic-immune system : structural considerations / T. Krenacs, I. Zsakovics and M. Rosendaal -- Approaches for studying the role(s) of gap junctions in the immune system / A.M. Glass, T.D. Nguyen, S. Taffet -- Gap junctions in antigen presenting cells / P.J. Saez, K.F. Shoji, J.C. Saez -- Connect the immune system : roles of gap junctions in antigen presentation and T cell activation / B. Pang, J. Neefjes -- Gap junctions and connexins in the immune defence against tumors / F. Salazar-Onfray -- Connexins in atherosclerosis / L. Burnier, B.R. Kwak -- Connexins in lung function and inflammation / M. Chanson, M. Koval -- The effect of oxidative stress on connexins in the vasculature / M. Billaud ... [et al.] -- The regulation of gap junctions and cellular coupling within the microvasculature in response to acute inflammation / D. Lidington, K. Tyml -- Impact of microglial activation on astroglial connexin expression and function in brain inflammation / C. Giaume ... [et al.] -- A role for connexins in inflammatory disorders of the epidermis / S. Donnelly, P. Martin -- Translating basic research on Cx43 gap junctions into therapies for reducing scarring and cardiac arrhythmia / J.M. Rhett ... [et al.] -- Connexin-based therapeutic approaches to inflammation in the central nervous system / J. Zhang ... [et al.] -- Enhancing epithelial tissue repair and reducing inflammation by targeting connexins / D.L. Becker ... [et al.].
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  • Constipation: A Practical Approach to Diagnosis and Treatment serves as an unmet resource for physicians and other health care providers, including trainees and students, who see patients with constipation. The text reviews pathophysiologic mechanisms and details evaluation and management strategies. The volume also enables the reader to identify epidemiologic factors and quality of life parameters for patients with constipation, discuss differences in pathophysiologic mechanisms for different etiologies of constipation, recognize primary causes of constipation, and assess special considerations related to the symptom of constipation including presentations in the elderly, in pregnant women, in patients with systemic diseases, and patients with a history of abuse. Written by thought leaders and recognized experts in gastrointestinal motility and medical education, Constipation: A Practical Approach to Diagnosis and Treatment is of great value and utility for gastroenterologists, primary care physicians, gynecologists, nurse practitioners, physician's assistants, as well as fellows and residents.
  • pt. B ScienceDirect
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  • 2013 ClinicalKey
    The Consultative Process -- A Systematic Approach to the Bleeding Patient: Correlation of Clinical Symptoms and Signs with Laboratory Testing -- Endothelium -- Hemophilia A and B -- Less Common Congenital Disorders of Hemostasis -- Acquired Coagulation Disorders Caused by Inhibitors -- von Willebrand Disease -- General Aspects of Thrombocytopenia, Platelet Transfusions, and Thrombopoietic Growth Factors -- Primary Immune Thrombocytopenia -- Congenital and Acquired Disorders of Platelet Function and Number -- Purpura and Other Hematovascular Disorders -- Disseminated Intravascular Coagulation -- The Crosstalk of Inflammation and Coagulation in Infectious Disease and Their Roles in Disseminated Intravascular Coagulation -- Thrombophilia: Clinical and Laboratory Assessment and Management -- Pediatric Aspects of Thrombophilia -- Deep Vein Thrombosis and Pulmonary Embolism -- Venous Thromboses at Unusual Sites -- Postthrombotic Syndrome -- Thrombocytosis: Essential Thrombocythemia and Reactive Causes -- Antiphospholipid Syndrome: Pathogenesis, Clinical Presentation, Diagnosis, and Patient Management -- Hemostatic Aspects of Cardiovascular Medicine -- Nonarteriosclerotic Arterial Occlusive Disease -- Thrombosis and Cancer -- Thrombotic Thrombocytopenic Purpura and Related Thrombotic Microangiopathies -- Heparin-Induced Thrombocytopenia -- Antithrombotic Agents -- Blood Component and Pharmacologic Therapy for Hemostatic Disorders -- Thrombolytic Therapy -- Topical Hemostatic Agents -- Therapeutic Apheresis: Applications for Hemorrhagic and Thrombotic Disorders -- Use of Vena Cava Filters and Venous Access Devices -- Dietary Supplements and Hemostasis -- Thrombotic Risk of Contraceptives and Other Hormonal Therapies -- Bleeding and the Management of Hemorrhagic Disorders in Pregnancy -- Thrombophilia in Pregnancy -- Surgery and Hemostasis -- Anticoagulation in the Perioperative Period -- Understanding and Managing the Coagulopathy of Liver Disease -- Outpatient Anticoagulant Therapy -- Point-of-Care Hemostasis Testing -- Prevention and Treatment of Venous Thromboembolism in Neurologic and Neurosurgical Patients -- Hematologic Interventions for Acute Central Nervous System Disease -- Atrial Septal Abnormalities and Cryptogenic Stroke -- Pulmonary Hypertension: Thrombotic and Nonthrombotic in Origin -- Hemorrhage Control and Thrombosis Following Severe Injury -- Hemostatic Aspects of Sickle Cell Disease -- Anticoagulation for Atrial Fibrillation and Prosthetic Cardiac Valves.
  • Consumer health informatics / Deborah Lewis, Betty L. Chang, Charles P. Friedman -- Empowered consumers / Patricia Flatley Brennan and Charles Safran -- Tailored health communication / Rita Kukafka -- Design and evaluation of consumer health information web sites / Gunther Eysenbach -- Information delivery methods / James H. Harrison, Jr. -- Delivery of online learning for healthcare consumers / Deborah Lewis -- Qualitative evaluation in consumer health informatics / Bonnie Kaplan -- Patient-to-patient communication: support groups and virtual communities / Gunther Eysenbach -- Electronic patient-centered communication: e-mail and other e-ways to communicate clinically / Daniel Z. Sands -- Consumer health vocabulary / Catherine Arnott Smith and P. Zoë Stavri -- Disability informatics / Richard Appleyard -- Ethical issues in consumer health informatics / Holly B. Jimison -- Social informatics and consumer health / Steve Sawyer -- Security of healthcare information systems / Roy Schoenberg -- The National Library of Medicine reaches out to consumers / Joyce E.B. Backus and Eve-Marie Lacroix -- Baby CareLink: collaborative tools to support families / Charles Safran and Denise Goldsmith -- CHOICEs: patients as participants in shared care planning at the point of care / Cornelia M. Ruland -- MedCERTAIN/MedCIRCLE: using semantic web technologies for quality management of health information on the web / Gunther Eysenbach -- The MI-HEART Project / Rita Kukafka, Yves A. Lussier, and James J. Cimino -- CHESS: 10 years of research and development in consumer health informatics for broad populations, including the underserved / David H. Gustafson ... [et al.].
  • Part I. Introducing the Domain and Levels of Service -- 1. Character of domain and organization of book -- 2. Economy 1: immanent mismatch between demand and supply of health care workforce -- 3. Level 0: searching-finding-trusting-acting-risking one's life? -- 4. Level 1: enhancing the provider- client relation through IT -- 5. Level 2: services without in-person contact between provider and client -- 6. Level 3: patient power on the web: the multifaceted role of personal health wisdom -- 7. Distinctive features of services conveyed through mobile apps -- Part II. Building Safety Nets Around the Active Client -- 8. Dimensions of patient risks and requirements for patient safety -- 9. Services for all stages of the metabolic syndrome and its consequences -- 10. Basic services reach out towards under-served populations -- 11. Smart homes: empowering the patient till the end -- 12. Partial solutions for patient safety -- Part III. Additional Methodology -- 13. Privacy and data protection: mission impossible? -- 14. The patient-centered electronic health record and patient portals -- 15. Scrutinized proof of effectiveness or cost effectiveness regarding patient reported outcomes -- 16. Economy 2: economic subsistence of services when research funding ends -- 17. Towards future consumer health informatics adapted health care legislation -- Trademarks -- Nomenclature -- General index -- Index of services.
  • pt. 1. Understanding consumer food choice and acceptance: 1. Integrating consumer responses to food products / H.L. Meiselman -- 2. Sensory perception as a basis of food acceptance and consumption / H. Tuorila -- 3. How does culture affect choice of foods? / P. Rozin -- 4. Psychobiological mechanisms in food choice / M.R. Yeomans -- 5. How do risk beliefs and ethics affect food choice? / A. Saba -- 6. Consumer attitudes to food innovation and technology / M. Siegris -- pt. 2. Determining consumers' food-related attitudes for food product development -- 7. Methods to understand consumer attitudes and motivations in food product development / D. Buck -- 8. Using means-end chains to understand food consumers' knowledge structures / A. Krystallis -- 9. Consumer attitude measures and food product development / K. Bruns and K. G. Grunert -- 10. Measuring consumer expectations to improve food product development / A.V. Cardello -- 11. Boredom and the reasons why some new food products fail / E.P. Koster and J. Mojet -- 12. SensoEmotional optimisation of food products and brands / D. Thomson -- pt. 3. Methods for consumer-led food product development -- 13. Sensory research and consumer-led food product development / H. Stone and J.L. Sidel -- 14. Opportunity identification in new product development and innovation in food product development / E. van Kleef and H.C.M. van Trijp -- 15. Consumer-driven concept development and innovation in food product development / H. Moskowitz -- 16. Consumer testing of food products using children / R. Popper and J.J. Kroll -- 17. The use of just-about-right (JAR) scales in food product development and reformulation / L. Rothman -- 18. Conducting difference testing and preference trials properly for food product development / M. O'Mahony -- 19. Thurstonian probabilistic approaches to new food product development / J.F. Delwiche -- 20. Using auctions to estimate prices and value of food products / Y. Loheac and S. Issanchou-- 21. The use of partial least squares methods in new food product development / M. Martens ... [et al.] -- 22. Case study of consumer-oriented food product development: reduced-calorie foods / J. Bogue and D. Sorenson -- 23. Preference mapping and food product development / H. MacFie.
  • Introduction -- Using existing theory to build a conceptual framework of consumer-run organizations -- Refining the preliminary framework to create the role framework -- Constructing journalistic life history narratives to explore the role framework -- Life history narratives from the P.S. Club -- Using narratives to understand how people benefit from CROs -- How organizations influence role development -- Role development and recovery -- Conclusion.
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  • "The fifth edition of Contact Dermatitis covers in detail every conceivable aspect of irritant and allergic contact dermatitis and its modern-day management. Special emphasis is given to immunological mechanisms, molecular aspects of sensitizers, atypical clinical forms, reactions to medicaments, and occupational and environmental factors. In order to optimize the diagnostic approach, a wide range of information is provided, including a dictionary of contact allergens. Retained chapters from the previous edition have been thoroughly revised to reflect the latest knowledge. Furthermore, completely new chapters have been added on a variety of topics, including genetics, the role of the skin barrier, the link between respiratory symptoms triggered by chemicals and contact dermatitis, and prevention. The editors and authors are all leading practitioners in the field. The comprehensive but approachable text is supplemented by a large number of full color illustrations and tables. Core messages highlight the most important information and will help the reader to gain a better understanding of the subject and greater competence in everyday practice."--Publisher's website.
  • 2012 ClinicalKey
    Examination and grading -- Anterior eye examination -- Grading scales -- Grading morphs -- Eyelids -- Blinking abnormalities -- Eyelid ptosis -- Meibomian gland dysfunction -- Eyelash disorders -- Tear film -- Dry eye -- Mucin balls -- Conjunctiva -- Conjunctival staining -- Conjunctival redness -- Papillary conjunctivitis -- Limbus -- Limbal redness -- Vascularized limbal keratitis -- Superior limbic keratoconjunctivitis -- Corneal epithelium -- Corneal staining -- Epithelial microcysts -- Epithelial oedema -- Epithelial wrinkling -- Stromal oedema -- Stromal thinning -- Deep stromal opacities -- Corneal neovascularization -- Corneal infiltrative events -- Microbial keratitis -- Corneal warpage -- Corneal endothelium -- Endothelial bedewing -- Endothelial blebs -- Endothelial cell redistribution -- Endothelial polymegethism -- Grading scales for contact lens complications -- Guillon tear film classification system.
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    "A rude place and an unpolisht man" : William Penn and the nature of Pennsylvania -- "An infancy of government" : population, authority, and the problem of proprietorship -- "A suitable charity or an effectual security" : community, contagion, and the care of strangers -- "A body corporate and politick" : association, interest, and improvement in a provincial city -- "Improvement in every part of the healing art" : transatlantic cultures of medical improvement -- "A fine field for professional improvement" : sites and sources of medical authority in the Revolutionary War -- "In a yielding state" : nervous nationalism in the new republic -- "Those friendly reciprocities" : panic and participation in the age of yellow fever -- "A matter of police" : fever and betrayal in the federal union.
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    How should we understand the fear and fascination elicited by the accounts of communicable disease outbreaks that proliferated, following the emergence of HIV, in scientific publications and the mainstream media? The repetition of particular characters, images, and story lines - of Patients Zero and superspreaders, hot zones and tenacious microbes - produced a formulaic narrative as they circulated through the media and were amplified in popular fiction and film. The "outbreak narrative" begins with the identification of an emerging infection, follows it through the global networks of contact and contagion, and ends with the epidemiological work that contains it. Priscilla Wald argues that we need to understand the appeal and persistence of the outbreak narrative because the stories we tell about disease emergence have consequences. As they disseminate information, they affect survival rates and contagion routes. They upset economies. They promote or mitigate the stigmatizing of individuals, groups, locales, behaviors, and lifestyles.
  • 1. Introduction: Colorectal Surgery - The Specialty / Nigel Scott and Lars Påhlman -- 2. Hemorrhoids / J. Graham Williams -- 3. Anal Fissure and Its Management / Aidan Fowler -- 4. Anorectal Fistula / Rick Nelson -- 5. The Management of Pilonidal Sinus Disease / Asha Senapati -- 6. Hidradenitis Suppurativa / Nigel Scott -- 7. Pruritus Ani / Ian Badger -- 8. Anorectal Sexually Transmitted Infections / Benjamin P. Goorney -- 9. Colorectal Cancer Screening and Surveillance / Susan K. Clark -- 10. Imaging in Colorectal Cancer / Rishi Sethi and Stephen H. Lee -- 11. Early Colorectal Cancer Management / Jim Hill -- 12. Colon Cancer: Advantages of the Laparoscopic Approach and the Principles of Enhanced Recovery / Hugh J. Gallagher and Sophie E. Noblett -- 13. Evidence-Based Management of Rectal Cancer / Paul Rooney and Nagarajan Pranesh -- 14. Chemotherapy and Biomarkers / Francisca E. Marti and Mark P. Saunders -- 15. Colorectal Liver Metastases / Saurabh Jamdar, Aali J. Sheen, and Ajith K. Siriwardena -- 16. Anal Cancer / Jim Hill -- 17. Medical Management of Ulcerative Colitis / Paul Flanagan and Keith Leiper -- 18. Surgical Options in Ulcerative Colitis / Daniel L. Beral and John E. Hartley -- 19. Surgery for Fulminant Colitis / Kaori Futaba, Tony Mak, and Dion Morton -- 20. Failing Pouch / Hasan T. Kirat and Feza H. Remzi -- 21. Surgery for Small Bowel Crohn's Disease / Paul Rooney and Nicola Eardley -- 22. Perianal Crohn's Disease / Nigel Scott -- 23. Surgical Nutrition / Ciaran J. Walsh -- 24. Diverticular Disease / Catherine McCarthy, Niklas Hennessy, and Basil Fozard -- 25. Assessment and Investigation of Fecal Incontinence and Constipation / Peter J. Mitchell and Edward S. Kiff -- 26. Interventions for Fecal Incontinence / Steven R. Brown -- 27. The Management of Constipation / Sushil Maslekar and David G. Jayne -- 28. Solitary Rectal Ulcer Syndrome and Pelvic Pain / Martin Farmer -- 29. Rectal Prolapse / J. Graham Williams -- 30. Acute Colonic Pseudo-obstruction / Keith Chapple -- 31. Colonic Volvulus / Lesley M. Hunt -- 32. Rectovaginal Endometriosis / Ian J. Adam -- 33. Stomas / Mark Cheetham -- 34. Intensive Care: The Basics / Jonathon R. Goodall -- 35. Critical Care Scoring Systems / Andrew Fisher and Dermot Burke -- 36. Surgical Fluid Management / Sophie E. Noblett and Alan F. Horgan -- 37. Colonic Bleeding / Rachael Lawrence and Helen O'Grady -- 38. Fecal Peritonitis / Arun Loganathan and John E. Hartley -- 39. Large Bowel Obstruction / Malcolm Wilson -- 40. Miscellaneous (Non-IBD) Colitides / Paul Turner and Ian Botterill -- 41. Colon and Rectal Trauma / Jeff Garner -- 42. Postoperative Complications / Sonia Lockwood and Jon Armitage.
  • A comprehensive guide to oral surgery procedures, this 6th Edition enhances your skills in evaluation, diagnosis, and patient management. Full-color photographs and drawings show how to perform basic surgical techniques, and an overview of more advanced surgical procedures includes guidelines on when to refer patients to specialists and how to provide supportive postoperative care. This edition also includes the latest developments in dental implants, instrumentation, and current technology. Written by well-known OMS educators James R. Hupp, Myron R. Tucker, and Edward Ellis III, this book is a reference for any dental office. UPDATED content on implants, new instruments, and the latest technology help you treat your patients more effectively. UPDATED Implant Treatment information is divided into two new chapters, one on basic concepts and techniques for clinical situations where adequate bone and soft tissue exists and implants can be placed into a well-healed area of bone. Another chapter on more complex concepts focusing on cases that require immediate implant placement and cases where bone and soft tissue augmentation may be required. UPDATED Facial Cosmetic Surgery chapter is organized by nonsurgical and surgical procedures, covering popular procedures such as dermal fillers, botox, facial resurfacing, browlift and forehead procedures, blepharoplasty, rhinoplasty, and rhytidectomy. UPDATED Medicolegal Considerations chapter reviews concepts of liability, risk management, methods of risk reduction, and actions that should be taken if a malpractice suit is filed against the dentist or a dentist's employee. UPDATED Correction of Dentofacial Deformities chapter includes new information on conventional treatment planning, image prediction, and 3D virtual computerized surgical planning. UPDATED Surgical Reconstruction of Defects of the Jaws chapter includes new information on Bone Morphogenetic Proteins (BMPs).
  • Contemporary psychodynamic theory profoundly impacts our understanding of the development of psychopathology in young patients. However, while much has been written about this theory's influence on the psychotherapy techniques used with adults, little attention has been paid to its practical clinical applications in psychotherapeutic work with children and adolescents. This book explains how the new concepts derived from contemporary psychodynamic theory have made it necessary to revise our understanding of and approach to young patients in psychotherapy. It reviews the recent contributions from contemporary two-person relational psychodynamic theory and employs detailed case examples to bring to life this theory's practical applications in child and adolescent psychotherapy. Psychotherapists and students of psychotherapy will find this book a valuable source of information on contemporary psychodynamic theory and a useful resource for introducing a contemporary style into their practice, co-constructing with the patient a narrative to achieve the desired goals.
  • Animal models for the study of erectile function and dysfunction -- Normal erectile physiology -- Psychological aspects of erectile dysfunction -- Epidemiology of erectile dysfunction and key risk factors -- Etiology and risk factors of erectile dysfunction -- Making the diagnosis of erectile dysfunction -- Drugs that affect sexual function -- Oral therapy for erectile dysfunction -- Self-injection, transurethral and topical therapy in erectile dysfunction -- Quantification of erectile dysfunction after prostate cancer treatment -- Vacuum constriction device: a new paradigm for treatment of erectile dysfunction -- Hormonal evaluation and therapy in erectile dysfunction -- Cardiovascular issues in the treatment of erectile dysfunction -- The penile prosthesis option for erectile dysfunction -- The effect of radical prostatectomy on erectile dysfunction -- Peyronie's disease: natural history, diagnosis, and medical therapy -- Peyronie's disease: surgical therapy -- Priapism: medical and surgical therapy -- Ejaculatory disorders.
  • Content-based image retrieval (CBIR) is the process of retrieval of images from a database that are similar to a query image, using measures derived from the images themselves, rather than relying on accompanying text or annotation. To achieve CBIR, the contents of the images need to be characterized by quantitative features; the features of the query image are compared with the features of each image in the database and images having high similarity with respect to the query image are retrieved and displayed. CBIR of medical images is a useful tool and could provide radiologists with assistance in the form of a display of relevant past cases. One of the challenging aspects of CBIR is to extract features from the images to represent their visual, diagnostic, or application-specific information content. In this book, methods are presented for preprocessing, segmentation, landmarking, feature extraction, and indexing of mammograms for CBIR. The preprocessing steps include anisotropic diffusion and the Wiener filter to remove noise and perform image enhancement. Techniques are described for segmentation of the breast and fibroglandular disk, including maximum entropy, a moment-preserving method, and Otsu's method. Image processing techniques are described for automatic detection of the nipple and the edge of the pectoral muscle via analysis in the Radon domain. By using the nipple and the pectoral muscle as landmarks, mammograms are divided into their internal, external, upper, and lower parts for further analysis. Methods are presented for feature extraction using texture analysis, shape analysis, granulometric analysis, moments, and statistical measures.
  • Embodied theories claim that semantic representations are grounded in sensorimotor systems, but the contribution of sensorimotor brain areas in representing meaning is still controversial. One current debate is whether activity in sensorimotor areas during language comprehension is automatic. Numerous neuroimaging studies reveal activity in perception and action areas during semantic processing that is automatic and independent of context, but increasing findings show that involvement of sensorimotor areas and the connectivity between word-form areas and sensorimotor areas can be modulated by contextual information. Context Effects on Embodied Representation of Language Concepts focuses on these findings and discusses the influences from word, phrase, and sentential contexts that emphasize either dominant conceptual features or non-dominant conceptual features. Reviews the findings about contextual modularityClarifies the invariant and flexible features of embodied lexical-semantic processing.
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  • "Continuous sedation until death (sometimes referred to as terminal sedation or palliative sedation) is an increasingly common practice in end-of-life care. However, it raises numerous medical, ethical, emotional and legal concerns, such as the reducing or removing of consciousness (and thus potentially causing 'subjective death'), the withholding of artificial nutrition and hydration, the proportionality of the sedation to the symptoms, its adequacy in actually relieving symptoms rather than simply giving onlookers the impression that the patient is undergoing a painless 'natural' death, and the perception that it may be functionally equivalent to euthanasia. This book brings together contributions from clinicians, ethicists, lawyers and social scientists, and discusses guidelines as well as clinical, emotional and legal aspects of the practice. The chapters shine a critical spotlight on areas of concern and on the validity of the justifications given for the practice, including in particular the doctrine of double effect"-- Provided by publisher.
  • Most general rheumatologists and OB/GYNs have limited experience in caring for rheumatic disease patients during pregnancy, and many do not have ready access to expert colleagues in this area. Contraception and Pregnancy in Patients with Rheumatic Disease fills this gap by presenting the basics of contraception, fertility treatment, and pregnancy in rheumatic disease patients. This comprehensive resource begins by introducing key concepts that clinicians need to know when assessing the pregnant rheumatic disease patient. It goes on to cover specific rheumatic conditions in pregnancy, including systemic lupus erythematosus, antiphospholipid syndrome, systemic sclerosis, inflammatory myositis, and more. The book concludes by explaining additional related reproductive issues such as contraception, neonatal lupus, and long-term outcome of children of rheumatic disease patients. With advances in rheumatology therapies, obstetric monitoring, and reproductive medicine technologies, increasing numbers of women with rheumatic diseases are pursuing pregnancy. Summarizing the current state of knowledge and presenting a general approach for assessment of the rheumatic disease, this book serves as an invaluable reference tool for both rheumatologists and OB/GYNs.
  • Now more than ever there is a need for youth to learn about and use contraception consistently and effectively. Contraception for Adolescent and Young Adult Womenis a valuable resource for gynecologists and primary care practitioners who are on the front lines when it comes to discussing, recommending, and prescribing contraceptive options to adolescent and young adult women. The book is filled with evidence-based information presented in an easy-to-access format, ideal for the busy clinician who needs information at his or her fingertips. The first chapter answers the question 'why is contraception important in this population?' and outlines the basics of the initial clinical visit. The book continues by covering each method of contraception currently available, and concludes with a survey of special issues pertinent to young women. In its entirety, the content lays the groundwork for helping providers improve clinical practice in contraceptive care, tailored to the unique needs of young women. This book serves as an excellent reference for family physicians, adolescent medicine physicians, gynecologists, and anyone who wishes to learn and implement best contraceptive counseling and provision practices.
  • Women with chronic medical problems are at higher risk for complications during pregnancy and, therefore, they are especially in need of appropriate preconception and contraception care. Furthermore, many women with chronic medical problems do not obtain adequate preconception and contraception care. Despite published guidelines by the Centers for Disease Control and Prevention, there is a substantial gap in medical practice regarding the use of contraception in women with co-existing medical problems. Contraception for the Medically Challenging Patient fills the gap that currently exists in the knowledge of correct contraceptive prescribing practice and shows that inappropriate contraindications can easily become a barrier to effective contraception use among women. Chapters highlight obsolete views about appropriate candidates for contraception and address the complex contraceptive needs of today's medically challenging patients with HIV/AIDS, uterine fibroids, or cardiac, neurologic or thyroid disease. The book gives attention to recommendations on the use of contraception in women with medical problems such as diabetes, obesity, epilepsy, and lupus, among others, and provides comprehensive information regarding the effects that certain drugs may have on contraceptive hormone levels. While national guidelines do exist for contraceptive eligibility, this book discusses in more detail the evidence behind the guideline recommendations and the nuances that clinicians confront in daily practice.
  • In 1994 the European Society of Urogenital Radiology (ESUR) set up a committee to consider the safety of contrast media used for diagnostic imaging. Subsequently the committee questioned ESUR members, reviewed the literature, proposed guidelines, and discussed these proposals with participants at the annual symposia of the society. The end result of this work was the successful first edition of this book, published in 2006, which was followed by an equally successful second edition in 2009. This third edition not only fully updates the previous edition, but also includes new chapters on complex topics such as use of contrast media in children and practical aspects of off-label contrast media use. The authorship includes members, past members, and non-members of the Contrast Media Safety Committee. Comprehensive consideration is given to the many different safety issues relating to iodine-based contrast media, gadolinium-based contrast media, microbubbles for ultrasound, and barium sulfate. The text includes chapters on both acute and delayed non-renal adverse reactions and on renal adverse reactions. All of the questions frequently raised in radiological practice are addressed. This book, presented in a handy, easy-to-use format, provides an invaluable, unique, and unparalleled source of information.
  • This book examines in detail the diagnostic impact of contrast-enhanced ultrasound in the evaluation of urinary tract pathology, paying particular attention to the diagnostic gain that may be expected in relation to other imaging techniques such as CT and MRI. The role of contrast-enhanced ultrasound is evaluated in a range of pathologies, including ischemia, trauma, inflammation, cystic lesions, and solid tumors, as well as in the imaging of anatomic variants. New applications, for example monitoring of kidney transplantation, assessment of urinary bladder lesions, and diagnosis of vesico-ureteric reflux, are also covered. The presented cases, drawn from the authors' personal clinical caseload, include images obtained using multimodality techniques, sometimes with 3D CT reconstruction. The authors' own experiences are compared with the most recent reports in the scientific literature.
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  • The pace of new research and level of innovation repeatedly introduced into the field of drug delivery to the lung is surprising given its state of maturity since the introduction of the pressurized metered dose inhaler over a half a century ago. It is clear that our understanding of pulmonary drug delivery has now evolved to the point that inhalation aerosols can be controlled both spatially and temporally to optimize their biological effects. These abilities include controlling lung deposition, by adopting formulation strategies or device technologies, and controlling drug uptake and release.
  • A short history of controlled drug release -- The organization of the gut and oral absorption of drugs: anatomical, biological and physiological considerations in oral formulation development -- Controlling drug release in oral product development programs: an industrial perspective -- Animal model systems suitable for controlled release modeling -- In Vitro testing of controlled release dosage forms during development and manufacture -- Oral controlled delivery mechanisms and technologies -- Drug-polymer matrices for extended release -- Ion-exchange approaches to controlling drug release -- Pulsatile delivery for controlling drug release -- Ordered mesoporous silica for the delivery of poorly soluble drugs -- Geometric release systems: principles, release mechanisms, kinetics, polymer science, and release-modifying material -- Extrudable technologies for controlling drug release -- Coated multiparticles for controlling drug release -- Capsules as a delivery system for modified-release products -- Lipids in oral controlled release drug delivery -- Biccal drug delivery -- Controlling release by gastroretention -- Drug delivery to the colon.
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    Introduction: Plastination in historical perspective / John D. Lantos -- Being non-biodegradable: the lonely fate of metameat / Catherine Belling -- Life-like humans : playing poker with James Bond and Ted Williams / George J. Annas -- More wondrous and more worthy to behold: the future of public anatomy / Geoffrey Rees -- Resisting the allure of the lifelike dead / Christine Montross -- Detachment has consequences: a note of caution from medical students' experiences of cadaver dissection / Farr A. Curlin -- The history and potential of public anatomy / Callum F. Ross -- What would Dr. William Hunter think about 'Bodies revealed?' / Lynda Payne -- 'Vive la difference': Gunther von Hagens and his maligned copycats / Linda Shulte-Sasse -- Normative objections to posing plastinated bodies: an ethics of bodily repose / Tarris Rosell -- For Ronnie and Donnie / Myra Christopher -- The creeping illusionizing of identity from neurobiology to newgenics / Barbara Maria Stafford.-- Craft and narrative in 'Body worlds': an aesthetic consideration / Neil A. Ward -- Afterword: Plastination's share of mind / Neil A. Ward, John D. Lantos.
  • Tennis Elbow -- Golf Elbow -- Proximal Radial Compression Syndrome -- so-called coracoiditis -- Sudeck̀s Dystrophy.
  • "Preface In pharmaceutical/clinical development of a test drug or treatment, relevant clinical data are usually collected from subjects with the diseases under study in order to evaluate safety and efficacy of the test drug or treatment under investigation. To provide accurate and reliable assessment, well-controlled clinical trials under valid study design are necessarily conducted. Clinical trial process is a lengthy and costly process, which is necessary to ensure a fair and reliable assessment of the test treatment under investigation. Clinical trial process consists of protocol development, trial conduct, data collection, statistical analysis/interpretation, and reporting. In practice, controversial issues evitably occur regardless the compliance of good statistical practice (GSP) and good clinical practice (GCP). Controversial issues in clinical trials are referred to as debatable issues that are commonly encountered during the conduct of clinical trials. In practice, controversial issues could be raised from, but are not limited to, (1) compromises between theoretical and real/common practices, (2) miscommunication and/or misunderstanding in perception/interpretation among regulatory agencies, clinical scientists, and biostatisticians, and (3) disagreement, inconsistency, miscommunication/misunderstanding, and errors in clinical practice"--Provided by publisher.
  • This book reviews the surgical management of patients with aortic disease, revealing many options open to cardiovascular specialists in this often controversial area of management. It reviews each controversy and provides clinical information for cardiac surgery, and discusses the spectrum of disorders and their management. With the knowledge base in this discipline changing rapidly, Controversies in Aortic Dissection and Aneurysmal Disease meets an important requirement to consolidate the wide-ranging information on which clinicians must base their practice. It is directed towards surgeons, physicians, and healthcare workers involved in the care of patients requiring cardiac, cardiothoracic and cardiovascular surgery. This book will be an essential resource for these professionals looking to accelerate the translation of basic research findings into clinical study and practice.
  • Trends in neurovascular surgery / Brian A. O'Shaughnessy [and others] -- Trends in endovascular surgery / Demetrius K. Lopes [and others] -- Novel approaches to neurovascular diseases / Michael L. DiLuna, Katie Pricola, and Murat Gunel -- Implications of trends in the marketplace for neurovascular diseases / Charles B. Wilson -- Neuroendovascular diseases: past, present, and future / Joseph M. Fitzgerald and Daniel Tuden -- Unruptured aneurysms: a neurological perspective / Nerissa U. Ko and Daryl R. Gress -- Unruptured aneurysms: a surgical perspective / Chirag D. Gandhi, Aman B. Patel, and Joshua B. Bederson -- Surgical treatment of anterior circulation aneurysms / G. Edward Vates and Art Day Shankar -- Endovascular treatment of anterior circulation aneurysms / Reza Jahan, Gary Duckwiler, and Fernando Vinuela -- Surgical considerations of posterior circulation aneurysms / Howard A. Riina and Robert F. Spetzler -- Endovascular treatment of posterior circulation aneurysms / Italo Linfante, Cole Blease Graham, III, and Ajay K. Wakhloo -- Treatment of cerebral arteriovenous malformations / Andrew Jea, Mustafa K. Bakaya, and Roberto C. Heros -- Endovascular treatment of arteriovenous malformations / Gary M. Nesbit [and others] -- Radiosurgical treatment of arteriovenous malformations / Douglas Kondziolka, L. Dade Lunsford, and John C. Flickinger -- Surgical treatment of intracranial dural arteriovenous fistulas / Y. Jonathan Zhang [and others]. Endovascular management of dural arteriovenous fistulas / Yasunari Niimi [and others] -- Surgical management of extracranial vascular occlusive disease / Brian E. Snell, Robert J. Wienecke, and Christopher M. Loftus -- Endovascular revascularization of carotid artery disease / Philip M. Meyers, Sean D. Lavine, and Randall T. Higashida -- Diagnosis and medical and endovascular management of intracranial atherosclerotic disease / Hunaldo Villalobos, Alan S. Boulos, and Lee R. Guterman -- The case for microsurgery in the treatment of cavernous malformations / Mustafa K. Bakaya, Andrew Jea, and Jacques J. Morcos -- Observation of cavernous malformations / Darryl Gress and Vineeta Singh -- The departmental model for practice in neurovascular disease / Christopher S. Ogilvy [and others] -- The institutional model for practice: an interventional neurovascular program within an academic neurological surgery department / T.C. Origitano, Harish Shownkeen, Mary Fitzgerald, and Trisha Cassidy -- The neurovascular center model for practice / Edwin J. Cunningham and Marc R. Mayberg -- Regionalization of neurovascular medicine / E. Sander Connolly, Jr., Mitchell F. Berman, and Robert A. Solomon -- Resolving controversy and uncertainty with evidence / S. Claiborne Johnston -- Developing the neurovascular surgical specialists of the future / Charles Y. Liu [and others] -- Developing the endovascular and neurovascular specialists of the future / Cameron G. McDougall.
  • Surgical removal of a tuberculum sellae meningioma : endoscopic vs. microscopic -- Management of a parasagittal meningioma involving the superior sagittal sinus -- Management of a petroclival meningioma -- Management of a small meningioma in a young patient -- Management of a vestibular schwannoma in a single hearing ear of a patient with neurofibromatosis type 2 -- Management of a trigeminal schwannoma : microsurgical removal vs. radiosurgery -- Surgical removal of a pituitary macroadenoma : endoscopic vs. microscopic -- Surgical approaches to a pituitary macroadenoma with cavernous sinus extensions : transcranial vs. transsphenoidal approach -- Total removal vs. subtotal removal with radiation of a craniopharyngioma -- Surgical approaches to a retrochiasmatic craniopharyngioma -- Glioma resection in eloquent areas -- Approaches to a colloid cyst : transcranial vs. endoscopic -- Management of an unruptured anterior communicating artery aneurysm : coiling -- Treatment of a giant ophthalmic aneurysm -- Treatment of a ruptured wide-neck basilar aneurysm -- Approaches to a basilar tip aneurysm -- Treatment of arteriovenous malformation in eloquent areas -- Management of symptomatic carotid stenosis -- Treatment of trigeminal neuralgia -- Treatment of intractable facial pain -- Deep brain stimulation with frame vs. frameless stereotactic -- The application of artificial discs -- Clinical trials : are they authoritative or flawed?
  • Obesity is a relatively new and controversial field of medicine. Some of the controversies surrounding obesity can be dismissed as myths, others reveal the lack of consensus and comprehensive knowledge which exist in obesity and its complex relationship with diabetes and other serious long-term conditions. Controversies in Obesity takes the unique approach of assessing the controversies surrounding obesity, thus seeking to debunk the myths and highlight and explore the genuine science, whilst demonstrating areas where there is healthy debate. This book will appeal to primary care physicians, trainees and specialist nurses involved in care of the obese patient, and would be of interest to anyone who wishes to gain a better understanding of the complex nature of obesity and its management.
  • Neonatal thrombocytopenia / Chakravorty, S.; Roberts, I. -- Pediatric and adolescent immune thrombocytopenia : prevention of bleeding versus burden of treatment / Cooper, N. -- Thrombosis in paediatrics : genetic versus environmental risk factors and implications for management / Monagle, P. -- Hematological problems in pediatric intensive care / Revel-Vilk, S.; Cox, P.; Robitaille, N.; Blanchette, V. -- New advances in the treatment of children with hemophilia / Lillicrap, D. -- Myelodysplastic and myeloproliferative diseases in children : current concepts / Vyas, P. -- Towards personalized medicine in childhood acute lymphoblastic leukaemia / Halsey, C. -- Reduced intensity conditioning in paediatric haematopoietic cell transplantation / Chiesa, R.; Veys, P. -- Can iron chelators replace stem cell transplantation in the treatment of thalassaemia syndromes? / Darbyshire, P.J. -- Iron deficiency : when and why oral iron may not be enough / Crary, S.E.; Buchanan, G.R. -- Principles of transitional care in haematology / Bolton-Maggs, P.; Choudhuri, S.
  • Arachnoid cysts -- Communicating hydrocephalus -- Noncommunicating hydrocephalus -- Compartmentalized hydrocephalus -- Slit ventricle syndrome -- Craniopharyngioma -- Optic pathway/hypothalamic gliomas -- Ependymomas -- Scaphocephaly/sagittal synostosis -- Deformational plagiocephaly -- Intracranial suppuration -- Chiari malformations -- Intractable epilepsy -- Moyamoya disease -- Pediatric aneurysms -- Myelomeningocele -- Lipomyelomeningocele/tethered cord -- Intramedullary spinal cord tumors -- Spasticity -- Syringomyelia.
  • "Controversies in Stereotactic Radiosurgery: Best Evidence Recommendations is a comprehensive reference that compiles, synthesizes, and summarizes the most relevant scientific literature on the topic. Each succinct, problem-oriented chapter addresses a different controversy surrounding stereotactic radiosurgery. This book saves physicians significant amounts of time by distilling years of scientific research into sound guidelines that will help them make fully-informed treatment decisions. Key Features: Covers both intracranial and spine radiosurgery, providing complete coverage of this rapidly evolving technology Includes more than 35 chapters on treatment controversies for brain and spine tumors as well as vascular malformations Contains summary tables throughout the text that present the main conclusions of published studies All neurosurgeons, radiation oncologists, and neuro-oncologists, involved in the treatment of patients who may be candidates for stereotactic radiosurgery of the brain and spine will find this book to be an essential decision making guide".
  • The worldwide prevalence of obesity has increased dramatically in recent years. Since the results of long-term dietary behavioral therapy remain sadly inadequate, surgery is currently the only effective treatment for patients with severe or morbid obesity. The numbers of weight loss operations continue to increase annually throughout the world. The anesthetic management of severely obese patients entails special challenges, especially when medical co-morbidities are present. Published outcome data on anesthetic care and pain management of these patients are scarce, and many practices remain controversial. Controversies in the Anesthetic Management of Obese Patients considers a wide range of important practical issues. Key questions in preoperative, intraoperative, and postoperative management are addressed, and different approaches are evaluated. Written by international leaders in the field, this book will be an invaluable aid for anesthesia care providers.
  • Gynecological cancers are some of the most commonly occurring malignancies in women. Despite their high incidence, treatment and management of these cancers remain controversial, with conflicting evidence about many aspects of the disease. Controversies in the Management of Gynecological Cancers offers a unique assessment of the opposing sides of the controversial issues associated with gynecological cancers, and aims to provide professionals in the field with a keener sense of the underlying evidence-base and a starting point from which to follow the ongoing debate. A section on the direction of future research to resolve these issues completes the discussion in each chapter. This book will appeal to specialists, trainees and healthcare workers in gynecological oncology, gynecologists, medical oncologists and radiation oncologists, and is an excellent starting point for anyone who wishes to gain a better understanding of the complex nature of the management of gynecological malignancy.
  • Prognostic factors in histopathology of lung cancer / A. Fisseler-Eckhoff -- FDG-PET/CT in lung cancer : an update / R.-P. Baum, C. Świętaszczyk, V. Prasad -- Whole-body magnetic resonance imaging for staging of lung cancer / R. Puls ... [et al.] -- Bronchoscopy/endobronchial ultrasound / F.J.F. Herth -- New developments in videomediastinoscopy : video-assisted mediastinoscopic lymphadenectomy and mediastinoscopic ultrasound / B. Witte -- Resection in stage I/II non-small cell lung cancer / F.M. Smolle-Juettner ... [et al.] -- Role of mediastinal lymph node dissection in non-small cell lung cancer / S. Bölükbas, M.H. Eberlein, J. Schirren -- Radiation therapy for early stage (I/II) non-small cell lung cancer / B. Jeremic ... [et al.] -- Stereotactic body radiation therapy for early non-small cell lung cancer / F. Zimmermann ... [et al.] -- Extended surgical resection in stage III non-small cell lung cancer / S. Hillinger, W. Weder -- Stage III : definitive chemoradiotherapy / R. Fietkau, S. Semrau -- Adjuvant therapy in early-stage non-small cell lung cancer / M. Serke -- Postoperative irradiation in non-small cell lung cancer / S. Höcht ... [et al.] -- Altered fractionation schemes in radiotherapy / M. Stuschke, C. Pöttgen -- Chemotherapy of advanced non-small cell lung cancer / R. Pirker, W. Minar -- Radiotherapy / I.A. Adamietz -- Treatment of limited disease small cell lung cancer / D. de Ruysscher -- Radiochemotherapy in extensive disease small cell lung cancer ED-SCLC / B. Jeremic ... [et al.] -- Radiotherapy for extensive stage small cell lung cancer / B.J. Slotman -- Controversies in the treatment of advanced stages of small cell lung cancer / A. Schmittel -- Complementary and alternative medicine in lung cancer patients : a neglected phenomenon? / O. Micke.
  • Prostate cancer and active surveillance / Abrahamsson, P.A. -- Radical Prostatectomy in the 21th Century: the gold standard for localized and locally advanced prostate cancer / Schostak, M.; Miller, K.; Schrader, M. -- Radiotherapy as primary treatment modality / Sia, M.; Rosewall, T.; Warde, P. -- Combined radiotherapy and hormonal therapy in the treatment of prostate cancer / Boehmer, D. -- Postoperative adjuvant radiotherapy: standard of care? / Bottke, D.; Wiegel, T. -- Adjuvant hormonal treatment: the bicalutamide early prostate cancer program / Wirth, M.P.; Hakenberg, O.W.; Froehner, M. -- Hormone therapy for prostate cancer: immediate initiation / Schostak, M.; Miller, K.; Schrader, M. -- Lymphadenectomy in prostate cancer: radioguided lymph node mapping: an adequate staging method / Winter, A.; Wawroschek, F. -- Radiotherapy in lymph-node positive prostate cancer patients: potentially curable?: single institutional experience regarding outcome and side effects / Goldner, G.; Pötter, R. -- Radiotherapy in biochemical recurrences after surgery for prostate cancer / Hocht, S. ... [et al.] -- Recurrence following radiotherapy / Desgrandchamps, F. -- Secondary hormonal manipulation / Merseburger, A.S. ... [et al.] -- Chemotherapy in hormone-refractory prostate cancer / Wolff, J.M. -- A randomized phase II trial comparing weekly taxotere + prednisone (P) versus prednisone alone in androgen-independent prostate cancer / Fossa, S.D. -- Hormone-refractory and metastatic prostate cancer: palliative radiotherapy / Moser, L.; Schubert, T.; Hinkelbein, W.
  • Cutaneous lymphomas - radiotherapeutic strategies / Wilson, L.D., Jones, G.W., Smith, B.D. -- The clinical impact of T cell receptor rearrangement analysis in cutaneous T cell lymphoma / Assaf, C. -- Classification of primary cutaneous lymphomas / Assaf, C. ... [et al.] -- Basal cell and squamous cell carcinoma - radiotherapeutic approaches / Panizzon, R.G. -- Kaposi's sarcoma - radiotherapeutic aspects / Niewald, M.; Räbe, C. -- Pathogenesis and clinical manifestation of Kaposi's sarcoma / Geilen, C.C., Husak, R., Steinhoff, M. -- Merkel cell carcinoma - clinical presentation and treatment / Moll, I. -- Merkel cell carcinoma - uncommon and aggressive cutaneous tumour / Greiner, R.H. ... [et al.] -- Potential of radiation therapy in the multimodal management of Merkel cell carcinoma / Becker, G., Bottke, D. -- Skin and other reactions to radiotherapy - clinical presentation and radiobiology of skin reactions / Dörr, W. -- Management of skin and related reactions to radiotherapy / Seegenschmiedt, H. -- Malignant melanoma - markers for progression and prognosis in malignant melanoma / Geilen, C.C. ... [et al.] -- Malignant melanoma - sentinel lymph node biopsy and surgical procedures / Kaufmann, R. -- The role of radiotherapy in malignant melanoma / Marnitz, S., Hoecht, S., Hinkelbein, W. -- Malignant melanoma: classification and staging of malignant melanoma / Eigentler, T.K., Garbe, C. -- Malignant melanoma: PET/CT as a staging procedure / Müller, S.P. -- Malignant melanoma - clinical development of peptide-based melanoma vaccines / Schmittel, A. ... [et al.].
  • Introducing a transdisciplinary approach to applied urban health research -- Benefits and challenges of transdisciplinary research for urban health researchers -- In search of empowering health research for marginalized populations in urban settings: the value of a transdisciplinary approach -- Reducing health disparities experienced by refugees resettled in urban areas: a community-based transdisciplinary intervention model -- The Street Health Report 2007: community-based research for social change -- Safety as a social value: revisiting a participatory case study in Scotland -- Methodological notes on conducting transdisciplinary research -- Collaborative processes in transdisciplinary research -- From complex problems to complex problem-solving: transdisciplinary practice as knowledge translation -- Transdisciplinary training in health research: distinctive features and future directions -- Funding agencies and transdisciplinary research -- Moving forward: the future of transdisciplinary health research.
  • Cooperation in primates and humans : closing the gap / Carel P. Van Schaik, Peter M. Kappeler -- Practicing Hamilton's rule : kin selection in primate groups / Joan B. Silk -- Kinship, competence and cooperation in primates / Bernard Chapais -- Reciprocal altruism : 30 years later / Robert L. Trivers -- Simple and complex reciprocity in primates / Frans B.M. de Waal, Sarah F. Brosnan -- Reciprocal exchange in chimpanzees and other primates / John C. Mitani -- Causes, consequences and mechanisms of reconciliation : the role of cooperation / Filippo Aureli, Colleen Schaffner -- Cooperative hunting in chimpanzees : kinship or mutualism? / Christophe Boesch, Hedwige Boesch, Linda Vigilant -- Toward a general model for male-male coalitions in primate groups / Carel P. Van Schaik, Sagar A. Pandit, Erin R. Vogel -- Cooperative breeding in mammals / Tim Clutton-Brock -- Non-offspring nursing in mammals : general implications from a case study on house mice / Barbara König -- Monkeys, markets and minds : biological markets and primate sociality / Louise Barrett, S. Peter Henzi -- Digging for the roots of trading / Ronald Noë -- Reputation, personal identity and cooperation in a social dilemma / Manfred Milinski -- Human cooperation from an economic perspective / Simon Gächter, Benedikt Hermann.
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  • Correlations of cellular activities in the nervous system : Physiological and methodological considerations -- Synchronization between sources : Emerging methods for understanding large-scale functional networks in the human brain -- Approaches to the detection of direct directed interactions in neuronal networks -- The phase oscillator approximation in neuroscience : An analytical framework to study coherent activity in neural networks -- From synchronisation to networks : Assessment of functional connectivity in the brain -- The size of neuronal assemblies, their frequency of synchronization, and their cognitive function -- Synchrony in neural networks underlying seizure generation in human partial epilepsies -- Detection of phase synchronization in multivariate single brain signals by a clustering approach -- Denoising and averaging techniques for electrophysiological data -- Dissection of synchronous population discharges in vitro -- Time-frequency methods and brain rhythm signal processing -- Complex network modeling : A new approach to neurosciences.
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  • Multiple components of COPD -- Clinical assessment of COPD -- Physiologic assessment of COPD -- Outcome measures and prognostic markers for COPD -- Management guidelines for chronic obstructive pulmonary disease -- Pharmacological therapy: bronchodilators -- Pharmacological therapy: inhaled corticosteroids -- Pharmacological therapy: novel approaches -- Smoking cessation -- Pulmonary rehabilitation -- Exacerbations of COPD -- Home management issues -- Co-morbidities and systemic effects of COPD -- Non-pharmacological and surgical management of COPD -- Depression and anxiety in COPD: diagnosis and management issues -- Disease management programs for COPD -- General management issues in COPD: sleep, travel, and preoperative management.
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  • Part I: An introduction to coping theory and research / H. Livneh and E. Martz -- Psychodynamic adn cognitive theories of coping / C.L. Radnitz and L. Tiersky -- Hierarchical coping : a conceptual framework for understanding coping within the context of chronic illness and disability / J. Chronister and F. Chan -- The social context of coping / J.F. Kosciulek -- Reauthoring the self : chronic sorrow and posttraumatic stress following the onset of CID / S. Roos and R.A. Neimeyer -- Adaptive tasks and methods of coping with illness and disability / R.H. Moos and C.J. Holahan. Part II: Coping with AIDS : the challenges of an evolving disease / J. Walkup and L. Cramer-Berness -- Coping with arthritis : from vulnerability to resilience / B.W. Smith and J. Dalen -- Coping with burn injury: research summary and a new model of the influence of coping on psychological complications / J.A. Fauerbach, M.G. Bresnick and M.T. Smith -- Coping with cancer : findings on research and intervention studies / S.L. Manne -- Coping with diabetes : psychological determinants of diabetes outcomes / J. Wagner and H. Tennen -- Coping with epilepsy : research and interventions / M. Bishop and C.A. Allen -- Coping with heart disease : implications for prevention and treatment / K.K. Bennett and J.L. Boothby -- Coping with multiple sclerosis : considerations and interventions / K. McNulty -- Coping with chronic pain : a stress-appraisal coping model / B.E. Thorn and K.E. Dixon -- Coping with severe mental illness : a multifaceted approach / S. Kravetz and D. Roe -- Coping with spinal cord injuries : wholeness is a state of mind / E. Martz and H. Livneh -- Coping with traumatic brain injury : existential challenges and managing hope / J.H. Hinkebein and R.C. Stucky -- Appendix of commonly used coping instruments.
  • History / Franca Buffoni -- Nomenclature and potential functions of copper amine oxidases / Sinéad Boyce ... [et al.] -- Cofactors of amine oxidases : copper ion and its substitution and the 2,4,5-trihydroxylphenylalanine quinone / Shinnichiro Suzuki ... [et al.] -- Copper amine oxidases from plants / Rosaria Medda ... [et al.] -- Soluble copper amine oxidases from mammals / Paola Pietrangeli ... [et al.] -- Membrane-bound copper amine oxidases / Andrew Holt -- Copper amine oxidase genes / Ivo Frébort and Hubert G. Schwelberger -- Mechanism of TPQ biogenesis in prokaryotic copper amine oxidase / Toshihide Okajima and Katsuyuki Tanizawa -- Copper amine oxidase crystal structures / J. Mitchell Guss, Giuseppe Zanotti, and Tiina A. Salminen -- Plasma amine oxidases in various clinical conditions and in apoptosis / Frans Boomsma, Anton H. van den Meiracker, and Antonio Toninello -- Copper amine oxidases in intestinal diseases / Wieslawa Agnieszka Fogel, Ewa Toporowska-Kowalska, and Anna Stasiak -- Copper amine oxidases in adipose tissue-related disorders / Christian Carpéné -- Copper amine oxidases in adhesion molecules in renal pathology and in Alzheimer's disease and VAP-1 in leukocyte migration / Peter Boor ... [et al.] -- Inhibitors of copper amine oxidases : past, present, and future / Marek Šebela and Lawrence M. Sayre -- Pharmacological applications of copper amine oxidases / Emanuela Masini and Laura Raimondi -- Copper amine oxidases as antioxidant and cardioprotective agents / Mircea Alexandru Mateescu and Réginald Nadeau -- Biotechnological aspects of copper amine oxidases / Roberto Stevanato -- Concluding remarks / David M. Dooley.
  • The development of new digital technologies has led to fundamental changes in the ways that cultural institutions fulfill their public missions of access, preservation, research, and education. Many institutions are developing publicly accessible Web sites that allow users to visit online exhibitions, search collection databases, access images of collection items, and in some cases create their own digital content. Digitization, however, also raises the possibility of copyright infringement. It is imperative that staff in libraries, archives, and museums understand fundamental copyright principles and how institutional procedures can be affected by the law. "Copyright and Cultural Institutions" was written to assist understanding and compliance with copyright law. It addresses the basics of copyright law and the exclusive rights of the copyright owner, the major exemptions used by cultural heritage institutions, and stresses the importance of "risk assessment" when conducting any digitization project. Case studies on digitizing oral histories and student work are also included.
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    1. Copyright basics -- 2. Copies for users -- 3. Library reserves -- 4. Permissions and licensing -- 5. Performance and display: libraries and other organizations -- 6. Performance and display: nonprofit educational institutions -- 7. Audiovisual works, sound records, and software -- 8. Photographs and graphics -- 9. The Internet and the Web -- 10. Interlibrary loan and document delivery -- 11. Preservation and archiving -- 12. Digitization -- 13. Miscellaneous issues -- Epilogue. Emerging challenges in copyright -- Appendix. When U.S. works pass in the public domain.
  • History / Jean-Pierre Vidalain and Louis Setiey -- Basic Science / Tarik Aït Si Selmi, Jean-Marc Semay, Valéry Barbour, Michel-Henri Fessy and Michel Bonnin, et al. -- The Corail® Hip Stem / Steve Young, Markus C. Michel, Tarik Aït Si Selmi, Camdon Fary and Jean-Charles Rollier, et al. -- Corail® Outcomes / Scott Brumby -- The Corail Revision Family / Tim Board -- Part II. Approaches, Bearings, Cups and Direction: The ABC ... and D of Corail® -- Approaches / David Beverland -- Bearings / David Beverland -- Cups / David Beverland -- Direction / David Beverland -- Part III. Case Studies -- Case Studies: Pot-Pourri / Tarik Aït Si Selmi -- Part IV. The Next 25 Years -- Medico-Economic Considerations: Money Does Not Buy Happiness / Jens Boldt -- Educational Programme in Eastern Europe: The Russian Experience / Jens Boldt -- Educational Programme from Europe to Asia Pacific: Travelling the Seven Seas / Jens Boldt -- Erratum / Jean-Pierre Vidalain, Tarik Aït Si Selmi, David Beverland, Steve Young and Tim Board, et al.
  • Core Concepts in Parenchymal Kidney Disease provides comprehensive and state-of-the-art information on the diagnosis, treatment, classification and pathogenesis of glomerular and tubulointerstitial diseases. Chapters feature various clinical scenarios and are authored by a team of renowned experts in the field. Experienced clinicians and trainees alike will find this authoritative reference to be a valuable resource and contribution to the literature.
  • 1. Transplantation Immunobiology / Melissa Yeung -- 2. Basic Histocompatibility Testing Methods / Kathryn J. Tinckam -- 3. Medical Evaluation of the Living Kidney Donor / Julie Lin -- 4. Evaluation of Renal Transplant Candidates / Martina M. McGrath and Mario F. Rubin -- 5. Surgical Management of the Renal Transplant Recipient / Sayeed K. Malek and Stefan G. Tullius -- 6. Overview of Immunosuppressive Therapies in Renal Transplantation / Steven Gabardi and Eric M. Tichy -- 7. Allograft Dysfunction: Diagnosis and Management / Colm C. Magee -- 8. Approach to Medical Complications After Kidney Transplantation / John Vella -- 9. Infectious Complications in Renal Transplant Recipients / Erik R. Dubberke and Daniel C. Brennan -- 10. Recurrent and De Novo Glomerulonephritis After Kidney Transplantation / Austin Hunt and Mark D. Denton.
  • Fluid, electrolyte, and acid-base disorders are central to the day-to-day practice of almost all areas of patient-centered medicine - both medical and surgical. Virtually every aspect of these disorders has experienced major developments in recent years. Core Concepts in the Disorders of Fluid, Electrolytes and Acid-Base Balance encompasses these new findings in comprehensive reviews of both pathophysiology and clinical management. In addition, this volume offers clinical examples providing step-by-step analysis of the pathophysiology, differential diagnosis, and management of selected clinical problems. Written by the leaders in researching and treating electrolyte disorders, this reference is an invaluable resource for both the nephrologist and the non-specialist physician, or medical trainee.
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    Comfort / Jeannine M. Brant -- Coping: psychosocial issues / Patricia M. Grimm -- Coping: altered body image and alopecia / Beth A. Freitas -- Coping: cultural issues / Joanne K. Itano -- Coping: survivorship issues and financial concerns / Susan Leigh -- Sexuality / Patricia W. Nishimoto -- Supportive care: dying and death / MargaretJ. Crowley -- Supportive care: rehabilitation and resources / Sue L. Frymark -- Supportive care: support therapies and procedures / Janis M. Petree -- Supportive care: pharmacologic interventions / Robert J. Ignoffo, Carol S. Viele, and Zoe Ngo -- Supportive care: nonpharmacologic interventions / Denise Murray Edwards -- Alterations in mobility, skin integrity, and neurologic status / Jennifer Douglas Pearce -- Myelosuppression / Dawn Camp-Sorrell -- Alterations in nutrition / Marilynn Berendt and Sherri D'Agostino -- Alterations in elimination / Annette W. Kuck and Elisa Ricciardi -- Alterations in ventilation / Leslie V. Matthews -- Alterations in circulation / Kristine Turner Story -- Metabolic emergencies / Barbara Holmes Gobel -- Structural emergencies / Jane C. Hunter -- Biology of cancer and carcinogenesis / Deborah L. Volker -- Immunology / Kristi V. Schmidt -- Genetics / Kathleen A. Calzone -- Nursing care of the client with breast cancer / Marjorie Bernice -- Nursing care of the client with lung cancer / Marie Flannery -- Nursing care of the client with cancers of the gastrointestinal tract / Roberta Anne Strohl -- Nursing care of the client with cancers of the reproductive system / Susan Vogt Temple and Cynthia H. Umstead -- Nursing care of the client with cancers of the urinary system / Maureen E. O'Rourke -- Nursing care of the client with skin cancer / Alice J. Longman -- Nursing care of the client with head and neck cancer / Ellen Carr -- Nursing care of the client with cancers of the neurologic system / Shirley J. Kern -- Nursing care of the client with leukemia / Molly J. Moran and Susan Ezzone -- Nursing care of the client with lymphoma or multiple myeloma / Ryan R. Iwamoto -- Nursing care of the client with bone and soft tissue cancers / Ellen Carr -- Nursing care of the client with HIV-related cancers / Theresa A. Moran -- Nursing implications of surgical treatment / Thomas J. Szopa -- Nursing implications of radiation therapy / Mary Ellyn Witt -- Nursing implications of biotherapy and molecular targeted therapy / Danielle M. Gale -- Nursing implications of antineoplastic therapy / Susan Vogt Temple and Barbara C. Poniatowski -- Principles of preparation, administration, and disposal of hazardous drugs / Jean M. Ellsworth-Wolk and Jan Hawthorne Maxson -- Nursing implications of hematopoietic stem cell transplantation / Terry Wikle Shapiro -- Complementary and alternative medicines / Paul Jay Ross -- Epidemiology and prevention of cancer / Sharon J. Olsen -- Early detection of cancer / Candis Morrison -- Application of the statement on the scope and standards of oncology nursing practice and evidence-based practice / Linda U. Krebs -- The education process / Patricia Agre -- Legal issues influencing cancer care / Mary Magee Guillatte -- Selected ethical issues in cancer care / Paul Nelson-Marten and Jacqueline J. Glover -- Cancer economics and health care reform / Molly Loney -- Professional issues in cancer care / Dianne N. Ishida.
  • "AHRQ examines features needed in pediatric electronic health records (EHRs) to ensure quality care for children. The report scanned scientific literature and gathered expert consensus on EHRs used in the care of children. Child health care providers stated that they need access to EHRs with special features to assure the delivery of quality care to pediatric patients. These features relate to a child's evolving physiology, maturity and associated conditions not found in EHRs used for adult patients. Key EHR functionalities for consideration include the ability to build and maintain vaccination records, record growth and development data, calculate weight and age-based medication dosing, manage pediatric diseases, identify pediatric norms such as developmental milestones, and document the relationship between pediatric patients and their parents and caregivers."--Publisher.
  • Every year, numerous articles on critical care topics are published, and it is increasingly difficult for the busy practitioner to keep abreast of the latest developments. This book provides a detailed review of state of the art knowledge as well as the latest research findings. It covers the core aspects in excellent detail, but is not so comprehensive as to make its daily use unfeasible. For each condition considered, discussion of the pathophysiology is integrated with observations on diagnosis and treatment in order to allow a deeper understanding. The book is scientifically based, with extensive references to published research. This will allow readers to investigate their individual interests further and will enable physicians to base their approach upon evidence rather than upon traditions or routines. Accordingly, clinicians will be able to justify measures by providing a coherent, evidence-based strategy and relevant citations where needed. Core Knowledge in Critical Care Medicine will appeal to experienced practitioners as an aide-mémoire, but will also be of great value to a wide range of more junior staff wishing to complement their background knowledge with important facts applicable to everyday practice.
  • Core pathology. 3rd ed. 2009
  • Blepharoplasty -- Facelift -- Rhinoplasty -- Otoplasty -- Abdominoplasty -- Facial injuries -- Local flaps for facial coverage -- Cleft lip repair -- Cleft palate -- Lower extremity reconstruction -- Chest reconstruction -- Back reconstruction -- Abdominal wall reconstruction -- Breast augmentation -- Mastopexy -- Reduction mammaplasty -- Implant based breast reconstruction -- Autologous breast reconstruction using abdominal flaps -- Essential anatomy of the upper extremity -- Examination of upper extremity -- Flexor tendon injury and reconstruction -- Nerve transfers -- Tendon transfers in the upper extremity -- Extensor tendon injuries.
  • Core psychiatry. 3rd ed. 2012
    "This is a new edition of a highly successful, award winning textbook for trainee psychiatrists, covering in one volume all the subjects required for the new MRCPsych and similar exams. Written in a highly engaging manner, it will also prove invaluable to qualified psychiatrists who need to keep up-to-date with the latest developments, as well as clinical psychologists, general practitioners, psychiatric nurses and senior medical students. Concise yet comprehensive, "Core Psychiatry" reflects the latest developments in the curriculum plus all that is new and essential in clinical practice and the sciences that underpin it. It includes new information on the new Mental Capacity Act and Mental Health Act as well as enhanced sections on psychopharmacology, old age psychiatry, child and adolescent psychiatry, forensic psychiatry and rehabilitation. The book also makes reference to the latest NICE guidelines and includes new sections on sleep medicine and trauma psychiatry."--Publisher's website.
  • "Core Techniques in Operative Neurosurgery provides step-by-step guidance to help you effectively manage the full range of cranial and spinal neurosurgical disorders. Drs. Rahul Jandial, Paul McCormick, and Peter Black offer their expertise and experience in consistent chapters that cover the indications and contraindications, pitfalls, tips and tricks, and more for each procedure. With access to the full text and procedural videos online at, you'll have everything you need to minimize risk and get the best results."--Publisher's website.
  • Evidence-based practice in surgery / Kathryn A. Rigby and Jonathan A. Michaels -- Outcomes and health economic issues in surgery / Sharath C.V. Paravastu and Jonathan A. Michaels -- Day case surgery / Paul Baskerville -- Abdominal hernias / Andrew C. de Beaux -- Organisation of emergency general surgical services and the early assessment and investigation of the acute abdomen / Simon Paterson-Brown -- Perforations of the upper gastrointestinal tract /Enders K.W. Ng -- Acute non-variceal upper gastrointestinal bleeding / Colin J. McKay and James Lau -- Pancreaticobiliary emergencies / Mark Duxbury -- Acute conditions of the small bowel and appendix / Peter Lamb -- Colonic emergencies / David E. Beck -- Anorectal emergencies / Felicity J. Creamer and B. James Mander -- Paediatric surgical emergencies / Dafydd A. Davies and Jacob C. Langer -- Abdominal trauma / Kenneth D. Boffard -- Venous thromboembolism : prevention, diagnosis and treatment / Rhona M. MaClean -- Patient assessment and surgical risk / Chris Deans -- Perioperative and intensive care management of the surgical patient / R. Michael Grounds and Andrew Rhodes -- Surgical nutrition / William G. Simpson and Steven D. Heys -- Abdominal sepsis and abdominal compartment syndrome / Emma Barrow and Iain D. Anderson -- Complications of bariatric surgery presenting to the general surgeon / Bruce R. Tulloh and Andrew C. de Beaux.
  • Covers the important elements of paediatric anaesthesia in a concise, structured manner, providing invaluable information for established and aspiring practitioners.
  • 2008 Springer
    2010 Springer
    The Cornea and external eye disease volumes of the series Essentials in Ophthalmology aim to present recent developments regarding the cornea, with a discussion of diagnostic measures and particular emphasis being placed on treatment.
  • 1. Corneal slit lamp techniques 2. Diseases of the lid: anatomic abnormalities -- 3. Diseases of the lid: tumors -- 4. Diseases of the lid: immunologic, infectious, and traumatic -- 5. Disorders of tear production and the lacrimal system -- 6. Conjunctival disease: tumors and anatomic abnormalities -- 7. Conjunctivitis -- 8. Cornea -- 9. Corneal manifestations of systemic disease and therapy -- 10. Lid, conjunctival, and corneal manifestations of chemical and biological warfare -- 11. Corneal dystrophies, ectatic disorders, and degenerations -- 12. Corneal infections -- 13. Interstitial keratitis -- 14. Noninfectious keratopathy -- 15. Immunologic disorders of the cornea -- 16. Corneal trauma -- 17. Contact lens complications -- 18. Disorders of the sclera -- 19. Iris tumors -- 20. Anterior uveitis -- 21. Penetrating keratoplasty -- 22. Deep anterior lamellar keratoplasty -- 23. Endothelial keratoplasty -- 24. Therapeutic and reconstructive procedures -- 25. Refractive surgery.
  • Cornea. 3rd ed. 2011
    V. I: Fundamentals and medical aspects of cornea and external disease. Basic science: cornea, sclera, ocular adnexa anatomy, physiology and pathophysiologic responses -- Examining and imaging the cornea and external eye -- Differential diagnosis of selected problems in corneal and external eye disease -- Eye banking -- The ocular adnexa -- The conjunctiva -- Diseases of the cornea -- The sclera and anterior uvea. V. II: Surgery of the cornea and conjunctiva. Keratoplasty -- Therapeutic procedures -- Keratoprosthesis -- Ocular surface transplantation -- Refractive surgery.
  • This book presents a unique approach not found in any other text for those looking to improve the clinical results of refractive surgery by gaining a better understanding of corneal biomechanics and the instrumentation related to it. Written by leading experts in the field, this book provides authoritative coverage of the interactions of the cornea and the bioinstrumentation, such as corneal topography, pachymetry, aberrometers, tonometry and optical coherence tomography. Organized in an easy-to-read manner, Corneal Biomechanics and Refractive Surgery is designed for refractive surgeons and general ophthalmologists alike and describes the biomechanical role of the corneal tissue and how each part is affected in refractive surgery. Additionally, showing what the bioinstrumentation can measure, how models can improve understanding of the interaction between biomechanics, bioinstrumentation, and refractive surgery, and how these models and bioinstrumentation together can improve the refractive results, are also discussed.
  • This book, written by leading clinicians and scientists, focuses on recent clinically relevant advances in the diagnosis and treatment of corneal disorders. After an opening chapter considering the latest knowledge on the heredity of keratoconus, important advances in corneal imaging are discussed, in particular the use of optical coherence tomography and in vivo confocal microscopy for evaluation of the normal and the diseased cornea. Antiangiogenic treatment options are then reviewed, and new aspects in the diagnosis and therapy of mycobacterial keratitis explained. Further chapters address the storage of donor cornea for penetrating and lamellar keratoplasty and the keratoplasty in infants. The book closes by discussing new developments in antibacterial chemotherapy for bacterial keratitis.
  • Corneal dystrophies (CD) are bilateral hereditary disorders of the cornea in which one or several parts of the cornea lose their transparency. As the dystrophy can start in different layers of the cornea, they are classified accordingly as epithelial dystrophies, stromal dystrophies and endothelial dystrophies. This volume includes a description of the new international IC3D classification of CD reflecting what we currently know of the clinical, pathological, and genetic aspects of these disorders. Further contributions give an insight into differential diagnostics and histology, which can confirm the diagnosis as for instance in granular CD type 2, as well as DNA analysis of CD providing additional information about the pathogenesis. Also, procedures such as the phototherapeutic keratectomy with the excimer laser, the new modalities of lamellar keratoplasty, and penetrating keratoplasty are described. This publication holds a wealth of new and topical information on CD for ophthalmologists and geneticists alike.
  • Continuous regeneration of the cornea is necessary to maintain this tissue in the transparent state that is essential for vision. Therapy for repair of the damaged anterior cornea is currently addressed through the transplantation of donor corneas or the delivery of limbal epithelial stem cells (LESC) to the ocular surface using amniotic membrane (AM) as a supporting scaffold. Research on the bioengineering of corneal equivalents as replacement tissue is underway to develop viable corneal prosthetics. Corneal Regenerative Medicine: Methods and Protocols provides a concise overview of essential techniques in the field of corneal regenerative medicine, highlighting novel strategies to guide the management of key therapies within this area of medicine. Divided into four convenient sections, topics include the identification, characterisation and cultivation of LESC, as well as the investigation of biopolymers used as the basis for corneal substitutes. Written in the successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, Corneal Regenerative Medicine: Methods and Protocols covers the fundamental techniques useful for both the laboratory and clinical settings.
  • This book is an informative and comprehensive guide to the essential techniques currently employed in corneal surgery. It focuses in particular on two principal areas: the treatment of corneal disorders by means of different forms of corneal transplantation and the use of the Excimer laser to treat refractive disorders. In order to facilitate learning and later deployment of the techniques a multimedia approach is used. Surgical steps are described clearly within the book and can then be observed in detail on the accompanying high-quality DVD. A further feature is the inclusion of a chapter devoted to wet lab training, which presents practical preparatory exercises that can be performed by the surgeon, in some cases at home. This book will be of particular value as a handy reference for ophthalmologists who are just embarking upon their surgical training. However, it will also be informative for trained eye surgeons, who will be able to compare their own practice with the presented procedures and to assimilate the latest techniques.
  • This updated, full-color 4th edition features a greatly expanded surgical focus for a practical guide to corneal surgery. The expert guidance of internationally renowned editors provides you with authoritative and current coverage that takes you from an in-depth exploration corneal function as related to corneal surgery through to the correction of refractive errors. New chapters ensure that you stay up-to-date on the latest developments in the field. This easy-to-use, state-of-the-art resource has been reorganized to focus strictly on surgery to provide you with more coverage of recent surgical advances. Featuring a DVD-ROM with video clips of common surgical procedures, this is a text no ophthalmologic surgeon should be without. Features the latest surgical techniques and postoperative management of penetrating and lamellar keratoplasty -to provide you with details on hot topics in the field. Makes use of full color throughout the text, as well as step-by-step surgical line illustrations and full-color photographs so you gain a more accurate visual understanding of corneal surgery. Emphasizes refractive surgery considerations, including technique, with supporting medical illustrations and video presentations. Includes a bonus DVD-ROM with video clips of the most common surgical procedures for an excellent "real-time" guide.
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    History of topography / Tracy Swartz ... [et al.] -- Anatomy and physiology of the cornea / Keming Yu ... [et al.] -- The optics of the cornea / David Coward, Tracy Swartz, Ming Wang -- Topographic technologies / Tracy Swartz ... [et al.] -- Axial, elevation, and pachymetric mapping / Ilan Cohen ... [et al.] -- Topographical scales / Ralph Chu and Megan Buliano -- Topography of normal cornea / Zuguo Liu, Xiao Yang, and Mei Zhang -- Topographic presentation of common corneal diseases / Zhenpin Zhang -- Pre-refractive surgery evaluation / Guillermo Avalos ... [et al.] -- Post-refractive surgery topographies / Roberto Pinelli -- Posterior corneal changes in refractive surgery / Amar Agarwal ... [et al.] -- Corneal topography and wavefront sensing: complementary tools / Gustavo E. Tamayo and Mario G. Serrano -- Combined wavefront and topography approach to refractive surgery treatments / Noel Alpins and George Stamatelatos -- LaserSight alternatives in topography-based custom ablation / Aleksandar Stojanovic -- Topography-guided corneal refractive treatment: the VISX model / Rejean Munger and Bruce Jackson -- The Magellean mapper / Michael Endl, Claus Fichte, and Jason Zornek -- The iTrace combination corneal topography and wavefront system by Tracey Technologies / Joe S. Wakil, Tom D. Padrick, and Sergey Molebny -- Bausch & Lomb Orbscan II/IIz anterior segment analysis system / Paul M. Karpecki -- Artemis VHF digital ultrasound technology / Dan Z. Reinstein and Ronald H. Silverman -- The Keratron and Keratron Scout corneal topographers / Renzo Mattioli and Nancy K. Tripoli -- The Tomey TMS corneal topographer / Stephen D. Klyce -- Topcon KR-9000PW / Naoyuki Maeda -- Three-dimensional stereo corneal topographic system: the AstraMax / Ming Wang, Shawna Hill, and Tracy Swartz -- Pentacam / Matthias Maus ... [et al.] -- Precisio / Tracy Swartz ... [et al.] -- The future of corneal topography / Arun C. Gulani and Ming Wang.
  • Coronary angioscopy 2015
  • 1. Coronary artery disease: pathological anatomy and pathogenesis -- 2. Clinical use of serum biomarkers in the prediction of cardiovascular risk -- 3. Medical management of serum lipids and coronary heart disease -- 4. Coronary artery disease: regulation of coronary blood flow -- 5. Coronary angiography -- 6. Diabetes and heart disease -- 7. Women and coronary artery disease -- 8. Exercise testing -- 9. The electrocardiogram in coronary artery disease -- 10. Echocardiographic evaluation of coronary artery disease -- 11. Myocardial perfusion imaging utilizing single photon emission computed tomography techniques -- 12. Clinical cardiac positron emission tomography -- 13. Magnetic resonance imaging of the myocardium, coronary arteries, and anomalous origin of coronary arteries -- 14. Computed tomograph cardiovascular imaging -- 15. Coronary heart disease syndromes: pathophysiology and clinical recognition -- 16. Evaluation of vulnerable atherosclerotic plaques -- 17. Medical treatment of stable angina -- 18. Medical treatment of unstable angina and acute non-ST-elevation myocardial infarction -- 19. Treatment of acute ST-elevation myocardial infarction -- 20. Medical treatment of heart failure and coronary heart disease -- 21. Surgical treatment of advanced heart failure -- 22. Kawasaki Disease -- 23. Percutaneous coronary intervention and the various coronary artery disease syndromes -- 24. Sudden cardiac death in coronary artery disease -- 25. Surgical treatment of coronary artery disease -- 26. Coronary artery bypass surgery and percutaneous coronary revascularization: impact on morbidity and mortality in patients with coronary artery disease -- 27. Cardiovascular genetics: focus on genetics of coronary artery disease -- 28. Preventive cardiology: the effects of exercise -- Index.
  • 1. Epidemiology of Cardiovascular Disease and Refractory Angina / Shahar Lavi, David E. Kandzari, and Gregory W. Barsness -- 2. Basic Science Concepts / Brendan Doyle and Noel Caplice -- 3. Coronary Artery Disease: Development and Progression / Joerg Herrmann and Amir Lerman -- 4. Therapeutic Goals in Patients with Refractory Angina / Mauricio G. Cohen and E. Magnus Ohman -- 5. Medical Therapy for Chronic Refractory Angina / Gregory W. Barsness, Thomas J. Kiernan, and David R. Holmes Jr. -- 6. EECP / A. Bart -- 7. Therapeutic Angiogenesis / Timothy D. Henry and Daniel Satran -- 8. Transmyocardial Laser Revascularization / Jignesh S. Shah, Joanna J. Wykrzykowska, and Roger J. Laham -- 9. Invasive and Device Management of Refractory Angina / E. Marc Jolicoeur, Gregory W. Barsness, and Martial G. Bourassa -- 10. Cardiac Transplantation for Ischemic Heart Disease / Robroy H. Mac Iver, Edwin C. McGee Jr., and Patrick M. McCarthy -- 11. Alternative Therapies for Chronic Refractory Coronary Artery Disease / Brent A. Bauer -- 12. Nonspecific Placebo Effects / Piero O. Bonetti -- 13. Prognostic Implications of Depression in Ischemic Syndromes / Karen E. Joynt and Christopher M. O'Connor -- 14. Secondary Prevention Strategies / Romero Corral Abel, Lopez Jimenez Francisco, Josef Korinek, Virend Somers, and Thomas E. Kottke.
  • 1. Anatomy of Coronary Vessels / Zeev Vlodaver and John R. Lesser -- 2. Cardiac Development and Congenital Heart Disease / Jamie L. Lohr, Cindy M. Martin, and Daniel J. Garry -- 3. Echocardiographic Evaluation of Ischemic Heart Disease / Richard W. Asinger, Fouad A. Bachour, and Gautam R. Shroff -- 4. Nuclear Imaging in Ischemic Heart Disease / Sharmila Dorbala and Marcelo F. Di Carli -- 5. Noninvasive Coronary Artery Imaging with CT and MRI / Marc C. Newell, Robert S. Schwartz, and John R. Lesser -- 6. Catheter-Based Coronary Angiography / Robert F. Wilson and Zeev Vlodaver -- 7. Coronary Artery Anomalies / Thomas Knickelbine, Michael Bolooki, and Zeev Vlodaver 8. Pathology of Chronic Obstructive Coronary Disease / Zeev Vlodaver -- 9. Vulnerable Plaque / Masataka Nakano, Frank D. Kolodgie, Fumiyuki Otsuka, Saami K. Yazdani, Elena R. Ladich, and Renu Virmani -- 10. Genetics and Coronary Heart Disease / Jennifer L. Hall, Ryan J. Palacio, and Eric M. Meslin -- 11. Endothelium Biology / Michael Sean McMurtry and Evangelos D. Michelakis 12. Stem Cells and Atherosclerosis / Jay H. Traverse -- 13. Induced Pluripotential Stem Cells and the Prospects for Cardiac Cell Therapy / Jonathan M.W. Slack and James R. Dutton -- 14. Regulation of Vasculogenesis and Angiogenesis / Rita C.R. Perlingeiro -- 15. Chronic Stable Angina / Santiago Garcia and Edward O. McFalls -- 16. Pathology of Sudden Death in Coronary Arterial Diseases / Shannon M. Mackey-Bojack, Emily R. Duncanson, and Susan J. Roe -- 17. Acute Coronary Syndromes / Robert F. Wilson -- 18. Complications of Acute Myocardial Infarction / Zeev Vlodaver and Robert F. Wilson -- 19. Healed Myocardial Infarction / Gary S. Francis and Daniel J. Garry -- 20. Nonatherosclerotic Ischemic Heart Disease / Uma S. Valeti, Robert F. Wilson, and Zeev Vlodaver 21. Transcatheter Treatment of Coronary Artery Disease / Robert F. Wilson -- 22. Surgical Treatment of Coronary Artery Disease / Kenneth Liao -- 23. Noncoronary Surgical Therapy for Ischemic Heart Disease / Christopher B. Komanapalli, Balaji Krishnan, and Ranjit John -- 24. Refractory Angina / Mohammad Sarraf, Daniel J. Hellrung, and Timothy D. Henry -- 25. Acute Catheter-Based Mechanical Circulatory Support / Gladwin S. Das, Ganesh Raveendran, and Jason C. Schultz -- 26. Surgical Mechanical Circulatory Support / Forum Kamdar and Ranjit John -- 27. Diabetes and Coronary Heart Disease / Graham T. McMahon -- 28. Cardiovascular Disease in Women / Margo Tolins-Mejia -- 29. Prevention of Coronary Artery Disease / Daniel Duprez -- 30. Innovations in Twenty-First Century Cardiovascular Medicine / Mary G. Garry, Joseph M. Metzger, Xiaozhong Shi, and Daniel J. Garry.
  • Healthy Living, p. 1-24 -- Lipids, p. 25-47 -- Diabetes Mellitus, p. 48-67 -- Hypertension, p. 68-91 -- Cardiac Investigations, p. 92-106 -- Coronary Artery Disease, p. 107-150 -- Chronic Stable Angina, p. 151-166 -- Acute Coronary Syndrome, p. 167-198 -- Heart Failure, p. 199-207 -- Arrhythmias, p. 208-212.
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  • In the past two decades a number of studies have shown that abnormalities in the function and structure of coronary microcirculation can be detected in several cardiovascular diseases. On the basis of the clinical setting in which it occurs, coronary microvascular dysfunction (CMD) can be classified into four types: CMD in the absence of any other cardiac disease; CMD in myocardial diseases; CMD in obstructive epicardial coronary artery disease; and iatrogenic CMD. In some instances CMD represents an epiphenomenon, whereas in others it represents an important marker of risk or may contribute to the pathogenesis of myocardial ischemia, becoming a possible therapeutic target. This book provides an update on coronary physiology and a systematic assessment of microvascular abnormalities in cardiovascular diseases, in the hope that it will assist clinicians in prevention, detection, and management of CMD in their everyday activity.
  • Coronary Anatomy / Gonda J. de Jonge, Peter M. A. van Ooijen, Jean-Louis Sablayrolles, Guido Ligabue and Felix Zijlstra -- Invasive Coronary Imaging / Michael R. Rees, Felix Zijlstra, Johan H. C. Reiber, Joan C. Tuinenburg and Gerhard Koning, et al. -- Non-Invasive Coronary Imaging / Thomas G. Flohr, Bernd Ohnesorge, Robert R. Edelman, Debiao Li and Hatem Alkadhi, et al. -- Non-Invasive Measurement of Coronary Atherosclerosis / Wilfred F. A. den Dunnen, Albert J. H. Suurmeijer, Rozemarijn Vliegenthart Proença, Christopher Herzog and Jaap M. Groen, et al. -- Multi-Dimensional Computed Cardiac Visualization / Peter M. A. van Ooijen, Wisnu Kristanto, Gonda J. de Jonge, Caroline Kuehnel and Anja Hennemuth, et al.
  • Development of coronary stents : a historical perspective / Richard A. Schatz and Christina Adams -- Fundamentals of bare and drug-eluting stents / Matthew J. Price and William Mosley -- Pre-clinical evaluation of coronary stents / Juan F. Granada, Armando Tellez, and Greg L. Kaluza -- Design, analysis, and interpretation of comparative effectiveness studies and randomized clinical trials of coronary stents / Robert Yeh and Neil J. Wimmer -- Pathology of drug-eluting stents in humans / Fumiyuki Otsuka [and others] -- Bioresorbable coronary scaffolds / John A. Ormiston [and others] -- Efficacy and safety of bare metal and drug-eluting stents / Karthik Gujja [and others] -- Restenosis-clinical presentation, evaluation, and treatment / Georgios J. Vlachojannis, Jennifer Yu, and Roxana Mehran -- Intravascular ultrasound guided coronary stent implantation / Ricardo A. Costa and Matthew J. Price -- Optical coherence tomography : stent implantation and evaluation / Hirosada Yamamoto and Marco A. Costa -- Fractional flow reserve-guided percutaneous coronary intervention / William F. Fearon -- Optimal antithrombotic therapy / Dominick J. Angiolillo -- The role of drug-eluting stents or cardiac bypass surgery in the treatment of multivessel coronary artery disease / Matthew J. Price -- Left main coronary artery stenting / Gill Louise Buchanan and Alaide Chieffo -- Stenting approaches to the bifurcation lesion / Andrejs Erglis -- Chronic total occlusions / J. Aaron Grantham, William L. Lombardi, and David Daniels -- Bypass graft intervention / Lawrence D. Lazar and Michael S. Lee -- Stenting in acute myocardial infarction / Marco Vaglimigli.
  • General concepts of blood vessel formation and remodeling -- Prenatal coronary Morphogenesis -- Postnatal coronary morphogenesis and growth -- Sturcture function of the coronary hierarchy -- Historical perspectives -- Coronary anomalies -- Aging -- Adaptations to exercise training -- Hypoxia -- Myocardial ischemia and infarction -- Cardiac hypertrophy -- Therapy for the coronary circulation.
  • Coronavirus genome structure and replication / D.A. Brian and R.S. Baric -- Coronavirus transcription : a perspective / S.G. Sawicki and D.L. Sawicki -- The coronavirus replicase / J. Ziebuhr -- Viral and cellular proteins involved in coronavirus replication / S.T. Shi and M.M.C. Lai -- Coronavirus reverse genetics by targeted RNA recombination / P.S. Masters and P.J.M. Rottier -- Coronavirus reverse genetics and development of vectors for gene expression / L. Enjuanes ... [et al.] -- Reverse genetics of coronaviruses using vaccinia virus vectors / V. Thiel and S.G. Siddell -- Development of mouse hepatitis virus and SARS-CoV infectious cDNA constructs / R.S. Baric and A.C. Sims.
  • Phylogenetic, structural, and functional relationships between WD and kelch repeat proteins / Andrew M. Hudson and Lynn Cooley -- Diversity of WD repeat proteins / Temple F. Smith -- A brief history of the coronin family / Eugenio L. de Hostos -- Molecular phylogeny and evolution of the coronin gene family / Reginald O. Morgan and M. Pilar Fernandez -- Coronin structure and implications / Bernadette McArdle and Andreas Hofmann -- Coronin : the double-edged sword of actin dynamics / Meghal Gandhi and Bruce L. Goode -- Invertebrate coronins / Maria C. Shina and Angelika A. Noegel -- Evolutionary and functional diversity of coronin proteins / Charles Peter Xavier ... [et al.] -- Role of mammalian coronin 7 in the biosynthetic pathway / Vasily Rybaki -- Coronin 1 in innate immunity / Jean Pieters -- The role of mammalian coronins in development and disease / David W. Roadcap, Christoph S. Clemen, and James E. Bear.
  • History of OSHA -- OSHA inspection procedures -- Corporate compliance management -- Preparing for an inspection OSHA inspection checklist -- OSHA penalty structure -- Defenses to an OSHA citation -- Criminal sanctions under the OSH act and beyond -- Occupational safety and health review commission -- Occupational safety and health review commission appeal procedures -- Operational compliance -- Multi-employer worksite issues -- Workers' compensation and safety -- Other litigation issues -- Other laws affecting the safety function -- Ethics in the safety profession -- Emerging issues in safety.
  • This new volume of Methods in Cell Biology looks at methods for analyzing correlative light and electron microscopy (CLEM). With CLEM, people try to combine the advantages of both worlds, i.e. the dynamics information obtained by light microscopy and the ultrastructure as provided by electron microscopy. This volume contains the latest techniques on correlative microscopy showing that combining two imaging modalities provides more than each technique alone. Most importantly it includes the essential protocols, including tips, tricks and images for you to repeat these exciting techniques in your own lab. With cutting-edge material, this comprehensive collection is intended to guide researchers for years to come.
  • Print Material
  • The study and modulation of cortical connections is a rapidly growing area in neuroscience. This unique book by prominent researchers in the field covers recent advances in this area. The first section of the book describes studies of cortical connections, modulation of cortical connectivity and changes in cortical connections with activities such as motor learning and grasping in primates. The second section covers the use of non-invasive brain stimulation to study and modulate cortical connectivity in humans. The last section describes changes in brain connectivity in neurological and psychiatric diseases, and potential new treatments that manipulate brain connectivity. This book provides an up-to-date view of the study of cortical connectivity, and covers its role in both fundamental neuroscience and potential clinical applications.
  • Schizophrenia genes: searching for common features, functions, and mechanisms -- Towards a molecular classification of illness: effects of schizophrenia susceptibility loci on clinical symptoms and cognitive function -- Homer: a genetic factor in schizophrenia? -- Neuroregulin-erbB signaling and the pathogenesis of schizophrenia -- Nicotinic cholinergic cortical dysfunction in schizophrenia -- Role for glutamate receptors, transporters, and interacting proteins in cortical dysfunction in schizophrenia -- Cortical circuit dysfunction in the NMDA receptor hypofunction model for the psychosis of schizophrenia -- Alterations in hippocampal function in schizophrenia: its genetic associations and systems implications -- Identifying novel target genes in psychotic disorder network association analyses -- Alterations in cortical GABA neurotransmission in schizophrenia: causes and consequences -- Increased cortical excitability as a critical element in schizophrenia pathophysiology.
  • This book reviews recent progress in cortical development research, focusing on the mechanisms of neural stem cell regulation, neuronal diversity and connectivity formation, and neocortical organization. Development of the cerebral cortex, the center for higher brain functions such as cognition, memory, and decision making, is one of the major targets of current research. The cerebral cortex is divided into many areas, including motor, sensory, and visual cortices, each of which consists of six layers containing a variety of neurons with different activities and connections. As this book explains, such diversity in neuronal types and connections is generated at various levels. First, neural stem cells change their competency over time, giving sequential rise to distinct types of neurons and glial cells: initially deep layer neurons, then superficial layer neurons, and lastly astrocytes. The activities and connections of neurons are further modulated via interactions with other brain regions, such as the thalamocortical circuit, and via input from the environment. This book on cortical development is essential reading for students, postdocs, and neurobiologists.
  • Corynebacterium diphtheriae is the classical etiological agent of diphtheria and the type strain of the genus Corynebacterium. While diphtheria of the respiratory tract became rare with the introduction of vaccination programs in industrialized countries, even today several thousand cases per year are reported to the World Health Organization. This shows that diphtheria is not completely eradicated and that reservoirs exist. The book summarizes the latest advances made in understanding C. diphtheriae and the closely related species Corynebacterium ulcerans and Corynebacterium pseudotuberculosis. Topics addressed are genomics of toxigenic corynebacteria, host-pathogen-interaction, detection, surveillance and treatment as well as application aspects.
  • Corynebacterium glutamicum was discovered in Japan in 1956 as a natural glutamate producer. Its "microbial factory" qualities, such as its physiological plasticity and robust catalytic functionalities, have since facilitated the development of efficient production processes for amino acids, nucleotides and vitamins. This monograph illustrates how the information gleaned from complete genome sequencing allows the rational engineering of the entire cellular metabolism and how systems biology permits the further optimization of C. glutamicum as a biocatalyst. Aspects of gene regulation, metabolic pathways, sugar uptake, protein secretion, cell division and biorefinery applications highlight the enormous biotechnological and biorefinery potential.
  • Improve your knowledge and treat patients with confidence using today's most advanced cosmeceutical treatments and expert guidance from author Zoe Diana Draelos, MD. Cosmeceuticals, 3rd Edition, a volume in the Procedures in Cosmetic Dermatology Series, covers cutting-edge content, keeping you up to date with developments in this rapidly-moving field so you can offer your patients the latest cosmeceutical therapies with optimal results.
  • Breast reconstruction with tissue expanders and implants -- Pedicled TRAM flap breast reconstruction -- Breast reconstruction with free TRAM flaps -- Breast reconstruction: perforator flaps (DIEP, SIEA) -- Breast reconstruction: superior gluteal artery perforator (SGAP) flap -- Latissimus dorsi breast reconstruction -- Breast reconstruction: repair of the partial mastectomy defect -- Mastopexy -- Breast augmentation -- Augmentation mastopexy -- Breast reduction: Wise pattern techniques -- Breast reduction: short scar (vertical) techniques -- Breast surgery in the masssive weight-loss patient -- Gynecomastia -- Nipple areola reconstruction.
  • Cosmetic dermatology 2009
    Approach to the cosmetic patient / David Beynet, Joseph Greco, and Teresa Soriano -- Cosmeceuticals / Lily Talakoub, Isaac M. Neuhaus, and Siegrid S. Yu -- Botulinum toxin for cosmetic use / Rajeev Mallipeddi and Sarah Weitzul -- Fillers / Jamison E. Strahan and Joel L. Cohen -- Chemical peels / Divya Singh-Behl and Rebecca Tung -- Vascular and pigment lasers / Jillian Havey and Murad Alam -- Ablative devices / Tina Bhutani and R. Sonia Batra -- Nonablative laser and light sources / Joy H. Kunishige and Paul M. Friedman -- Skin tightening with radiofrequence and other devices / Carolyn I. Jacob and Amy Forman Taub -- Hair transplantation / Daniel Berg and Paul C. Cotterill -- Liposuction / Murad Alam -- Advanced cosmetic surgical procedures / Brain Somoano, Jeremy Kampp, and Hayes B. Gladstone.
  • This book provides a highly illustrated, case-based approach to common face and neck procedures. In this full-color reference, internationally renowned surgeon Joe Niamtu III, DMD, covers techniques including brow, face, and neck lifts; nose, eye, and ear surgery; cosmetic surgery practice with discussions of the process of facial aging, diagnosing and consulting with patients, clinical digital facial implants; skin resurfacing; the use of neurotoxins; and the removal of skin lesions. The book also prepares you for photography, and anesthesia considerations. In a companion DVD, video clips feature Dr. Niamtu demonstrating key procedures addressed in the text.
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    Report 1. Medicaid hospital costs -- Report 2. Medicare hospital costs.
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  • The Practice of Pediatric Anesthesia -- Growth and Development -- Perioperative Behavioral Stress in Children -- Preoperative Evaluation, Premedication, and Induction of Anesthesia -- Ethical Issues in Pediatric Anesthesiology -- Pharmacokinetics and Pharmacology of Drugs Used in Children -- Total Intravenous Anesthesia and Target-Controlled Infusion -- Fluid Management -- Essentials of Hematology -- Strategies for Blood Product Management and Reducing Transfusions -- Essentials of Pulmonology -- The Pediatric Airway -- Anesthesia for Thoracic Surgery -- Essentials of Cardiology -- Anesthesia for Children Undergoing Heart Surgery -- Cardiac Physiology and Pharmacology -- Cardiopulmonary Bypass and Management -- Medications for Hemostasis -- Mechanical Circulatory Support -- Interventional Cardiology -- Anesthesia for Noncardiac Surgery in Children with Congenital Heart Disease -- Essentials of Neurology and Neuromuscular Disorders -- Surgery, Anesthesia, and the Immature Brain -- Pediatric Neurosurgical Anesthesia -- Essentials of Endocrinology -- Essentials of Nephrology -- General Abdominal and Urologic Surgery -- Essentials of Hepatology -- Organ Transplantation -- Orthopedic and Spinal Surgery -- Otorhinolaryngologic Procedures -- Ophthalmology -- Plastic and Reconstructive Surgery -- Burn Injuries -- The Extremely Premature Infant (Micropremie) -- Neonatal Emergencies -- Fetal Intervention and the EXIT Procedure -- Trauma -- Cardiopulmonary Resuscitation -- Malignant Hyperthermia -- Regional Anesthesia -- Ultrasound-Guided Regional Anesthesia -- Acute Pain -- Chronic Pain -- Anesthesia Outside the Operating Room -- The Postanesthesia Care Unit and Beyond -- Sedation for Diagnostic and Therapeutic Procedures Outside the Operating Room -- Procedures for Vascular Access -- Infectious Disease Considerations for the Operating Room -- Pediatric Anesthesia in Developing Countries -- Pediatric Equipment -- Medicolegal Issues -- Simulation in Pediatric Anesthesia.
  • 5th Edition, edited by James E. Cottrell, MD, FRCA and William L. Young, MD, delivers the complete and authoritative guidance you need to ensure optimal perioperative safety for neurosurgical patients. Integrating current scientific principles with the newest clinical applications, it not only explains what to do under any set of circumstances but also why to do it and how to avoid complications. Comprehensive updates reflect all of the latest developments in neurosurgical anesthesia, and contributions from many new experts provide fresh insights into overcoming tough clinical challenges.
  • The United States is a high priority target, and the goal of today's terrorist is body count. Our enemies can kill thousands with just a small amount of chemical or biological agent. This book details the characteristics, actions, identification, and containment of possible agents. With chapters on chemical agents, biological agents, explosive, nuclear, and incendiary devices, the author prepares the first responder to handle everything from re-establishing control and on-scene triage, to monitoring and detection techniques, decontamination, and training resources. It provides step-by-step procedures for recognizing and identifying terrorist incidents. Explores scene security, crime scene, isolation issues and recommended protective equipment and decontamination procedures. Provides guidance for all emergency responders to terrorist incidents, including fire, EMS, and law enforcement.
  • Foreword / Robert Kupperman, Stephanie Lanz -- Acknowledgments -- Introduction -- 1. What is terrorism, who are terrorists, what do they do? -- 2. Common elements of terrorism -- 3. Terrorism defense planning -- 4. Bomb defense planning -- 5. Hostage situations -- 6. Kidnapping -- 7. Threat of weapons of mass destruction -- 8. Domestic terrorism -- 9. Bomb incidents -- 10. Hostage incidents -- 11. Postblast environment -- 12. Hostage/Kidnapping aftermath -- 13. Interviewing victims -- 14. Role of the commander -- 15. The command post -- 16. A closer look at 9/11 -- Appendix A. Government-sponsored terrorism -- Appendix B. Foreign terrorist organizations (FTOs) -- Index.
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    Coupled bioluminescent reactions in practice -- Coupled bioluminescent cytotoxicity assays -- The role of coupled bioluminescent assays in kinase screening and study -- Coupled bioluminescent phosphatase assays -- Acetylcholinesterase -- Measurement of nitric oxide synthase activity by coupled bioluminescence -- The coupled bioluminescent pyrophosphorolysis assay -- Coupled luminescent assays of G-protein-coupled receptors -- Coupled bioluminescent protease assays -- Coupled luminescent assays involving aequorin -- Coupled bioluminescent reporter assays -- Coupled bioluminescent assays : regulatory concerns -- Coupled bioluminescent determination of bioburden and sterility -- Environmental applications of coupled bioluminescent assays.
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    "Trouble in the Beth Israel Hospital Association" -- The formative years -- From little house on the hill to modern institution -- A modern hospital surviving depression and war -- Medicine at the Beth, 1928-1947 -- The modern institution at midcentury -- Medical research at midcentury -- Redefining the Beth's community -- The changing shape of health care.
  • History and Prospects of Coxiella burnetii Research / Karim E. Hechemy -- Phylogenetic Diversity, Virulence and Comparative Genomics / Erin J. van Schaik and James E. Samuel -- Defense Mechanisms Against Oxidative Stress in Coxiella burnetii: Adaptation to a Unique Intracellular Niche / Katja Mertens and James E. Samuel -- Lipopolysaccharide of Coxiella burnetii / Craig T. Narasaki and Rudolf Toman -- Components of Protective Immunity / Guoquan Zhang, Yan Zhang and James E. Samuel -- Proteome of Coxiella burnetii / Robert Ihnatko, Edward Shaw and Rudolf Toman -- Coxiella Subversion of Intracellular Host Signaling / S. Kauser Hussain and Daniel E. Voth -- The Coxiella burnetii Parasitophorous Vacuole / Eric Ghigo, María I. Colombo and Robert A. Heinzen -- Coxiella burnetii Secretion Systems / Justin A. McDonough, Hayley J. Newton and Craig R. Roy -- Role of Lipids in Coxiella burnetii Infection / Stacey D. Gilk -- Axenic Growth of Coxiella burnetii / Anders Omsland -- Developmental Biology of Coxiella burnetii / Michael F. Minnick and Rahul Raghavan -- Genetic Manipulation of Coxiella burnetii / Paul A. Beare -- Role of Innate and Adaptive Immunity in the Control of Q Fever / Christian Capo and Jean-Louis Mege -- Immune Response and Coxiella burnetii Invasion / Amira Ben Amara, Yassina Bechah and Jean-Louis Mege -- Antigenic Analysis for Vaccines and Diagnostics / Laura R. Hendrix and Chen Chen -- Epidemic Q Fever in Humans in the Netherlands / Wim van der Hoek, Gabriëlla Morroy, Nicole H. M. Renders, Peter C. Wever and Mirjam H. A. Hermans, et al. -- Coxiella-like Endosymbionts / Jianmin Zhong -- Molecular Typing of Coxiella burnetii (Q Fever) / Robert F. Massung, Sally J. Cutler and Dimitrios Frangoulidis.
  • CPT data files 2011
    STAT!Ref, Limited to 7 simultaneous users
  • CPT Online 2011
    STAT!Ref, Limited to 7 simultaneous users
  • This beautifully illustrated book combines a detailed exposition of the anatomy and function of the cranial nerves with practical coverage of clinical concepts for the assessment and differential diagnosis of cranial nerve dysfunction. An introductory chapter provides a brief overview of cranial nerve anatomy and function, skull base anatomy, classification of pathologies, and imaging approaches. Each of the twelve chapters that follow is devoted to in-depth coverage of a different cranial nerve. These chapters open with detailed discussion of the various functions of each nerve and normal anatomy. The authors then describe common lesions and present a series of cases that are complemented by CT images and MRIs to illustrate disease entities that result in cranial nerve dysfunction.
  • Evolution of techniques to approach the base of the skull -- Instruments -- Subfrontal approaches -- Supraorbital eyebrow approach: a less invasive corridor to lesions of the anterior cranial fossa, parasellar region, and ventral brainstem -- Frontotemporal approach -- Orbitozygomatic approach -- Transcallosal approaches to intraventrical tumors -- Subtemporal approach -- Suboccipital lateral approaches (presigmoid) -- Suboccipital lateral approaches (retrosigmoid) -- Suboccipital median approach -- Middle cranial fossa approach -- Translabyrinthine and transcochlear petrosal approaches -- Dorsolateral approach to the craniocervical junction -- Transsphenoidal approaches: endoscopic -- Endonasal endoscope-assisted microscopic approach -- Transsphenoidal approaches: microscopic -- Expanded endoscopic endonasal approaches to the skull base -- Maxillofacial surgery: evolution and approaches -- Orbital approaches -- Transoral approaches -- Midfacial approaches -- Midfacial translocation approach -- Transmandibular approaches -- Anterior cranial base reconstruction.
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    Mechanisms of embryology -- Early embryonic development -- Early orofacial development -- Pharyngeal arches -- Pharyngeal pouches and pharyngeal grooves-- Bone development and growth -- Calvaria -- Cranial base -- Facial skeleton -- Palate -- Paranasal sinuses -- Mandible -- Temporomandibular joint -- Skull growth : sutures and cephalometrics -- Tongue and tonsils -- Salivary glands -- Muscle development -- Special sense organs -- Development of the dentition (Odontogenesis) -- Craniofacial disorders with known single gene mutations.
  • Of the approximately 640 muscles in the human body, over 10% of them are found in the craniofacial region. The craniofacial muscles are involved in a number of crucial non-locomotor activities, and are critical to the most basic functions of life, including vision, taste, chewing and food manipulation, swallowing, respiration, speech, as well as regulating facial expression and controlling facial aperture patency. Despite their importance, the biology of these small skeletal muscles is relatively unexplored. Only recently have we begun to understand their unique embryonic development and the genes that control it and characteristic features that separate them from the skeletal muscle stereotype.This book is the most comprehensive reference to date on craniofacial muscle development, structure, function, and disease. It details the state-of-the-art basic science of the craniofacial muscles, and describes their unique response to major neuromuscular conditions. Most importantly, the text highlights how the craniofacial muscles are different from most skeletal muscles, and why they have been viewed as a distinct allotype. In addition, the text points to major gaps in our knowledge about these very important skeletal muscles and identified key gaps in our knowledge and areas primed for further study and discovery.
  • Developmental anatomy of craniofacial sutures / Rice, D.P. -- Locate, condense, differentiate, grow and confront: developmental mechanisms controlling intramembranous bone and suture formation and function / Rice, D.P.; Rice, R. -- Mechanical influences on suture development and patency / Herring, S.W. -- Suture neontology and paleontology: the bases for where, when and how boundaries between bones have been established and have evolved / Depew, M.J.; Compagnucci, C.; Griffin, J. -- Single suture craniosynostosis: diagnosis and imaging / Hukki, J.; Saarinen, P.; Kangasniemi, M. -- Clinical features of syndromic craniosynostosis / Rice, D.P. -- Genetics of craniosynostosis: genes, syndromes, mutations and genotype-phenotype correlations / Passos-Bueno, M.R. ... [et al.] -- Roles of FGFR2 and twist in human craniosynostosis: insights from genetic mutations in cranial osteoblasts / Marie, P.J.; Kaabeche, K.; Guenou, H. -- Fibroblast growth factor signaling in cranial suture development and pathogenesis / Hajihosseini, M.K. -- Tgf-€ regulation of suture morphogenesis and growth / Rawlins, J.T.; Opperman, L.A. -- The BMP pathway in skull vault development / Maxson, R.; Ishii, M. -- Current treatment of craniosynostosis and future therapeutic directions / Wan, D.C. ... [et al.].
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  • "Terms of interest to the nutritionist are listed alphabetically. Included are medical terms, food science terms, metabolic terms, physiologic terms, drug terms, biotechnology terms and nutrition terms. Since Nutrition and Foods are integrated sciences not all of these terms will be useful to all readers. However, there should be a large number useful to many readers. The third edition provides many more terms than were provided in the earlier editions. A web address has been included to give the reader access to the extensive Tables of Food Composition maintained by USDA. In addition, a web address for Dietary Reference Intakes has been included to again provide the most current recommendations for nutrient intakes. These recommendations are in a state of flux. As the information base expands with respect to nutrient use and need, the DRIs are changed to reflect this newer knowledge. Included in this edition are the many drugs that are used to manage nutrition-related conditions. Cardiovascular disease, diabetes, hypertension, obesity, and so forth are diseases that, while incurable, are manageable. Many medical conditions have a nutrient component to their development as well as a genetic component and the major ones are described. Some of the rare genetic diseases relevant to nutrition and metabolism are also listed. Many drugs used in the management of chronic disease are of interest to the nutritionist so these drugs are listed."--Excerpts from publisher notes.
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    v. 1. General principles.
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    [sect. A. General data].--sect. B. Instruments and measurements.
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    v. 1. Bacteria.--v. 2. Fungi, algae, protozoa, and viruses.--v. 3. Microbial composition : amino acids, proteins, and nucleic acids.--v. 4. Microbial composition : carbohydrates, lipids, and minerals.--v. 5. Microbial products.--v. 6. Growth and metabolism.--v. 7. Microbial transformation.--v. 8. Toxins and enzymes.--v. 9, pt. A. Antibiotics.
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    v. 1. Disaccharides -- v. 2. Trisaccharides
  • Human Basic Genetics and Patterns of Inheritance -- Normal Early Development -- Amniotic Fluid Dynamics -- Multiple Gestation: The Biology of Twinning -- Biology of Parturition -- Immunology of Pregnancy -- Maternal Cardiovascular, Respiratory, and Renal Adaptation to Pregnancy -- Endocrinology of Pregnancy -- The Breast and the Physiology of Lactation -- Maternal Nutrition -- Developmental Origins of Health and Disease -- Fetal Cardiovascular Physiology -- Behavioral States in the Fetus: Relationship to Fetal Health and Development -- Placental Respiratory Gas Exchange and Fetal Oxygenation -- Fetal Lung Development and Surfactant -- Evidence-Based Practice in Perinatal Medicine -- Performing and Documenting the Fetal Anatomy Ultrasound Examination -- Doppler Ultrasound: Select Fetal and Maternal Applications -- Clinical Applications of Three-Dimensional Sonography in Obstetrics -- Central Nervous System Imaging Cephalocele -- Imaging of the Face and Neck Cleft Lip and Palate -- Thoracic Imaging -- Fetal Cardiac Malformations and Arrhythmias: Detection, Diagnosis, Management, and Prognosis -- Abdominal Imaging -- Urogenital Imaging -- Skeletal Imaging -- Placenta and Umbilical Cord Imaging Marginal and Velamentous Umbilical Cord Insertion -- Uterus and Adnexae Imaging Adnexal Mass, Complex and Simple -- First-Trimester Imaging -- Prenatal Diagnosis of Congenital Disorders -- Teratogenesis and Environmental Exposure -- Assessment of Fetal Health -- Intrapartum Fetal Surveillance -- Assessment and Induction of Fetal Pulmonary Maturity -- Invasive Fetal Therapy -- Hemolytic Disease of the Fetus and Newborn -- Nonimmune Hydrops -- Multiple Gestation: Clinical Characteristics and Management -- Pathogenesis of Spontaneous Preterm Birth -- Preterm Labor and Birth -- Cervical Insufficiency -- Premature Rupture of the Membranes -- Clinical Aspects of Normal and Abnormal Labor -- Recurrent Pregnancy Loss -- Stillbirth -- Placenta Previa, Placenta Accreta, Abruptio Placentae, and Vasa Previa -- Intrauterine Growth Restriction -- Pregnancy-Related Hypertension -- Patient Safety in Obstetrics -- Maternal Mortality -- Maternal and Fetal Infections -- Cardiac Diseases -- Coagulation Disorders in Pregnancy -- Thromboembolic Disease in Pregnancy -- Anemia and Pregnancy -- Malignancy and Pregnancy -- Renal Disorders -- Respiratory Diseases in Pregnancy -- Diabetes in Pregnancy -- Thyroid Disease and Pregnancy -- Other Endocrine Disorders of Pregnancy -- Gastrointestinal Disease in Pregnancy -- Diseases of the Liver, Biliary System, and Pancreas -- Pregnancy and Rheumatic Diseases -- Neurologic Disorders -- Management of Depression and Psychoses in Pregnancy and in the Puerperium -- Substance Abuse in Pregnancy -- The Skin and Pregnancy -- Benign Gynecologic Conditions in Pregnancy -- Anesthesia Considerations for Complicated Pregnancies -- Intensive Care Considerations for the Critically Ill Parturient -- Neonatal Morbidities of Prenatal and Perinatal Origin.
  • Development of the cerebellum -- Structural cerebellar plasticity -- Cell physiological cerebellar plasticity -- Imaging of cerebellar activity -- Oscillations and synchrony in cerebellar cortex and inferior olive -- Cerebellar motor control -- Cerebellar neuro-anatomical organization -- Excitability in cerebellar cortex -- Cerebellar pathology -- Epilogue.
  • Latinos and the Changing Demographic Landscape: Key Dimensions for Infrastructure Building --Latino Mental Health: Acculturation Challenges in Service Provision -- Building Response Capacity: The Need for Universally Available Language Services -- Increasing Service Parity Through Organizational Cultural Competence -- Building Infrastructure Through Training and Interdisciplinary Collaboration -- Investing in the Future: Expanding Educational Opportunities for First-Generation Latino College Students -- Putting Students to Work: Spanish Community Service Learning as a Countervailing Force -- Serving Latino Families Caring for a Person with Serious Mental Illness -- The Plight of Latino Youth in the Juvenile Justice System: Considerations for Mental Health Treatment -- Promoting the Well-Being of Unaccompanied Immigrant Minors -- Latinos in Rural Areas: Addressing Mental Health Disparities in New Growth Communities -- Life During and After Breast Cancer: Providing Community-based Comprehensive Services to Latinas -- Lessons Learned from HIV Service Provision: Using a Targeted Behavioral Health Approach -- Private Practice with Latinos: Brief Reflections and Suggestions.
  • "Mobile technology has transformed our lives, and personal genomics is revolutionizing biology. But despite the availability of technologies that can provide wireless, personalized health care at lower cost, the medical community has resisted change. In The Creative Destruction of Medicine, Eric Topol--one of the nation's top physicians--calls for consumer activism to demand innovation and the democratization of medical care." -- [Publisher-provided data]
  • Crib death or sudden infant death syndrome is surely among the worst emotional tragedies that any parent can experience. It is the most frequent death-causing syndrome during the first year of life, striking one infant in every 700-1,000. Crib death is a great enigma, and one of the main open issues in the social-medical and scientific setting of contemporary medicine. Despite a wide spectrum of theories and years of research, its etiology remains unclear. The scarcity of knowledge in the field of crib death and its pathology has led to continued and growing concern, prompting an expanding search for explanation that will permit either prediction or rapid diagnosis. This book describes systematic studies of the cardiovascular system and autonomic nervous system carried out in a large number of infants, newborns, and fetuses who have died suddenly and unexpectedly, as well as in age-matched control cases. The cardiovascular and neuropathological findings are presented in detail, and the relationship between crib death and unexplained perinatal death is discussed. This monograph will aid pathologists, forensic pathologists, pediatricians, obstetricians, and neonatologists in recognizing all potential morphological substrata. It puts forward a well-researched standardized postmortem protocol to be applied in all cases of sudden unexpected infant and perinatal death.
  • Poisoners throughout history -- Types of poisons -- Poisoners -- Victims -- Crime scene investigation -- The forensic autopsy -- Proving poisoning -- Poisoners in court -- Poisoning in fiction -- Conclusion.
  • Peface : The evolution of crime action profiling -- What is criminal profiling? -- Smoke and mirrors : the illusions of accuracy in criminal profiles -- Rhetoric vs reality : investigating the skills and accuracy of criminal profiling -- The components and processes of criminal profiling -- Defining serial violent crime -- Operational interpretation of the CAP models -- Criminal profiling of serial rape offenses -- Criminal profiling of sexual murder offenses -- Criminal profiling of serial arson offenses -- Offense location patterns : geographic profiles -- Procedural considerations and format guidelines -- Fighting fire with fire -- Understanding descriptive and inferential statistics : a beginner's guide -- Variable and coding tables.
  • The Human Factors: Errors and Skills -- The Challenge of Acute Healthcare -- The Nature of Error -- The Psychology of Human Action -- Human Perception: The Way We See Things -- Human Perception: The Way We See Things -- Information Processing and Mental Models: World Views -- Goals and Plans: Turning Points for Success -- Attention: The Focus of Consciousness -- Stress -- Strategies for Action:Ways to Achieve Good Decisions -- The Key to Success: Teamwork -- Speech is Golden: Communication -- Leadership -- Organizations and Accidents -- Reliable Acute Care Medicine.
  • "Disasters and public health emergencies can stress health care systems to the breaking point and disrupt delivery of vital medical services. During such crises, hospitals and long-term care facilities may be without power; trained staff, ambulances, medical supplies and beds could be in short supply; and alternate care facilities may need to be used. Planning for these situations is necessary to provide the best possible health care during a crisis and, if needed, equitably allocate scarce resources. Crisis Standards of Care: A Toolkit for Indicators and Triggers examines indicators and triggers that guide the implementation of crisis standards of care and provides a discussion toolkit to help stakeholders establish indicators and triggers for their own communities. Together, indicators and triggers help guide operational decision making about providing care during public health and medical emergencies and disasters. Indicators and triggers represent the information and actions taken at specific thresholds that guide incident recognition, response, and recovery. This report discusses indicators and triggers for both a slow onset scenario, such as pandemic influenza, and a no-notice scenario, such as an earthquake. Crisis Standards of Care features discussion toolkits customized to help various stakeholders develop indicators and triggers for their own organizations, agencies, and jurisdictions. The toolkit contains scenarios, key questions, and examples of indicators, triggers, and tactics to help promote discussion. In addition to common elements designed to facilitate integrated planning, the toolkit contains chapters specifically customized for emergency management, public health, emergency medical services, hospital and acute care, and out-of-hospital care."--Publisher's description.
  • CRISPR-Cas is a recently discovered defense system which protects bacteria and archaea against invasion by mobile genetic elements such as viruses and plasmids. A wide spectrum of distinct CRISPR-Cas immune systems has been identified in at least half of the available prokaryotic genomes. On-going biochemical and functional analyses have resulted in substantial insight into the functions and possible applications of these fascinating systems, although many secrets remain to be uncovered. In this book, experts summarize the state of the art of this exciting field.
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    Angela Dawson, M.D., appears to have it all: at the age of thirty-seven, she owns a fabulous New York City apartment, a stunning seaside house on Nantucket, and enjoys the perks of her prosperous lifestyle. But her climb to the top was rough, marked by a troubled childhood, a failed marriage, and the devastating blow of bankruptcy as a primary-care internist. Painfully aware of the role of economics in modern life, particularly in the health-care field, Angela returned to school to earn an MBA. Armed with a shiny new degree and blessed with determination, intelligence, and impeccable timing, Angela founded a start-up company, Angels Healthcare, then took it public. With her controlling interest in three busy specialty hospitals in New York City and plans for others in Miami and Los Angeles, Angela's future looked very bright.Then a surge of drug-resistant staph infections in all three hospitals devastates Angela's carefully constructed world. Not only do the infections result in patient deaths, but the fatalities also cause stock prices to tumble, leaving market analysts wondering if Angela will be able to hold her empire together. New York City medical examiners Laurie Montgomery and Jack Stapleton are naturally intrigued by the uptick in staph-related post-procedure deaths. Aside from their own professional curiosity, there's a personal stake as well: Laurie and Jack are newly married, and Jack is facing surgery to repair a torn ligament at Angels Orthopedic Hospital. Despite Jack's protests, Laurie can't help investigating-opening a Pandora's box of corporate intrigue that threatens not just her livelihood, but her life with Jack as well. Danger in the Hospital! MRSA strikes multiple hospitals-- in Robin Cook's new novel, Critical. This tightly written medical thriller interweaves drug resistance, cross infection, and the perils of postoperative complications in standalone surgicenters. It also juxtaposes the perspective of an orthopedic patient/physician with the business interests of a physician/entrepreneur.
  • Critical care emergency medicine 2015
    AccessEmergency Medicine
  • Anorexia and bulimia nervosa are serious disorders affecting pre-adolescents, adolescents and adults with high levels of co-morbidity, disability and mortality. The medical manifestations of these disorders are intrinsic to the illness and its treatment; some are secondary to malnutrition whereas others are the result of purging or other weight-controlling behaviours and a further group is due to poor management of nutritional problems. This book focuses on the role of the psychiatric, medical, nutritional and psychiatric assessment and management of severely ill patients with anorexia nervosa. Leading clinicians and researchers address the essentials of risk assessment, the identification of complications and the monitoring of treatment progress. Location of care and the role of the team are fully addressed, with due consideration of legal and ethical issues. Practical guidelines are included on risk assessment, management of acute and chronic physical problems, feeding during treatment and consent, as outlined in the MARSIPAN (2010) and Junior MARSIPAN (2012) documents. Critical Care for Anorexia Nervosa will be of value for medical and paediatric teams, GPs, psychiatrists℗ℓand all health-care professionals involved in the treatment of acutely ill patients with℗ℓanorexia℗ℓnervosa.
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  • Critical care in spinal cord injury / Michael G. Fehlings -- Epidemiology of traumatic and nontraumatic spinal cord injury / Vanessa K. Noonan, Marcel F. Dvorak & Michael G. Fehlings -- Novel insights into pathophysiology and emerging therapeutic opportunities / Nicole Forgione & Michael G. Fehlings -- Imaging evaluation of the injured spinal column and spinal cord / David W. Cadotte, David Mikulis & Michael G. Fehlings -- Acute spinal cord injury : clinical evaluation, diagnosis and classification / W. Bradley Jacobs & Rita Nguyen -- Nonoperative management of acute spinal cord injury / Steven Kirshblum, Monifa Brooks, Jeremiah Nieves & Peter Yonclas -- Surgery for acute spinal cord injury / Ravichandra A. Madineni, Angud Mehdi & James S. Harrop -- Principles of spinal cord rehabilitation / Michelle L. Starkey, Markus Wirz, Thomas M. Kessler & Armin Curt -- Prognosis for spinal cord injury / Fin Biering-Sørensen & Ralph Marino -- Emerging therapies for traumatic spinal cord injury / Newton Cho & Anick Nater -- Index.
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    Hemodynamics -- Hemodynamic monitoring -- Support of the failing circulation -- Arrhythmias, pacing, and cardioversion -- Respiratory monitoring -- Airway intubation -- Indications and options for mechanical ventilation -- Practical problems and complications of mechanical ventilation -- Positive end-expiratory and continuous positive airway pressure -- Weaning and discontinuation of mechanical ventilation -- Intensive care unit imaging -- Acid-base disorders -- Fluid and electrolyte disorders -- Blood conservation and transfusion -- Pharmacotherapy -- Nutritional assessment and support -- Analgesia, sedation, and therapeutic paralysis -- General supportive care -- Quality improvement and cost control -- Cardiopulmonary arrest -- Acute coronary syndromes -- Hypertensive emergencies -- Venous thromboembolism -- Oxygenation failure, ARDS, and acute lung injury -- Ventilatory failure -- ICU infections -- Severe sepsis -- Thermal disorders -- Acute kidney injury and renal replacement therapy -- Clotting and bleeding disorders and anticoagulation therapy -- Hepatic failure -- Endocrine emergencies -- Drug overdose and poisoning -- Neurological emergencies -- Chest trauma -- Acute abdomen -- Gastrointestinal bleeding -- Burns and inhalational injury.
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  • Take the best possible care of adult critical care patients with Critical Care Medicine: Principles of Diagnosis and Management in the Adult! Editors Dr. Joseph Parrillo and Dr. Phillip Dellinger, two of the most respected names in critical care medicine, combine their extensive knowledge with that of hundreds of top authorities in the field to bring you expert, state-of-the-art answers to any clinical question you may face in the intensive care unit. Learn from ICU specialists worldwide with contributions from an increased number of international authorities. Effectively manage common complications in the ICU with updated coverage of severe sepsis, septic shock, surgical infections, neurogenic and anaphylactic shock, severe heart failure, acute coronary syndromes, and Acute Respiratory Distress Syndrome. - Publisher.
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  • Because of the increase in serious kidney diseases, including end-stage renal disease, your role as a nephrologist, intensivist, surgeon, or critical care physician is quickly expanding. Well received in its 1st edition, this 2nd edition continues to provide comprehensive coverage of the latest advances in critical care procedures for the adult or pediatric patient with renal diseases or disorders. Presents a common language and standardized guidelines to help multi-disciplinary physicians caring for the critically ill communicate more effectively. A new US editor, detailed discussions of different forms of organ support, artificial organs, infections, acute illness occurring in chronic hemodialysis patients, and much more make this book an exceptional resource for anyone who treats critically ill renal patients. And, as an Expert Consult title, this meticulously updated 2nd edition comes with access to the complete contents online, fully searchable.
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  • Transition from the fetal to the neonatal circulation -- Triage and transport of infants and children with cardiac disease -- Airway control, mechanical ventilation, and respiratory care -- Heart-lung interactions -- Cardiac catheterization -- Echocardiography -- Cardiac anesthesia -- A pharmacokinetic and pharmacodynamic review -- Sedation and analgesia -- Monitoring of the cardiac patient -- The effects of cardiopulmonary bypass following pediatric cardiac surgery -- Nursing care of the pediatric cardiac patient -- Cardiac database and risk factor assessment. Outcomes analysis for congenital cardiac disease -- Patent ductus arteriosus -- Atrial septal defects -- Ventricular septal defects -- Complete atrioventricular septal defects -- Aortopulmonary window -- Tetralogy of Fallot -- Tetralogy of Fallot with absent pulmonary valve -- Tetralogy of Fallot with pulmonary atresia -- Pulmonary atresia with intact interventricular septum -- Pulmonary stenosis -- Left ventricular outflow tract obstruction -- Coarctation of the aorta -- Interrupted aortic arch -- Mitral valve anomalies and related disorders -- Mitral stenosis -- Prosthetic valves -- Hypoplastic left heart syndrome -- Single ventricle. General aspects -- Anomalous pulmonary veins -- Dextro-transposition fo the great arteries -- Congenitally corrected transposition of the great arteries (ccTGA) or Levo-transposition of the great arteries (l-TGA) -- Truncus arteriosus -- Double outlet right ventricle -- Ebstein's disease -- Anomalous coronary arteries -- Aortic valve regurgitation -- Vascular rings and pulmonary sling -- Takayasu arteritis -- Aortic dissection -- Tracheal resection -- Acute pulmonary hypertension -- Chronic pulmonary hypertension -- Acute myocarditis and cardiomyopathies -- Pericardial diseases -- Infective endocarditis -- Cardiac failure -- Shock in the cardiac patient: a brief overview -- Mechanical circulatory support in pediatric cardiac surgery -- Heart transplantation -- Arrhythmias in the intensive care unit -- Pacemakers (temporary and permanent), implantable cardioverter defibrillators (ICDs) and cardiac resynchronization therapy -- Discontinuation of life: ethical and legal issues -- Respiratory complications: acute respiratory distress syndrome, chylothorax, diaphragmatic palsy, and functional and respiratory physiotherapy -- Gastrointestinal complications: necrotizing enterocolitis, malrotation, and protein losing enteropathy -- Malnutrition and feeding difficulties: guidelines for enteral and parenteral nutrition -- Hematological aspects: anticoagulation, heparin-induced thrombocytopenia, plasma exchange -- Renal failure and replacement therapy -- Neurological complications: intracranial bleeding, stroke and seizures -- Infections in the cardiac intensive care unit -- Skin protection.
  • Critical care radiology 2011
    Thieme Book
    1. Basic Principles: Radiologic Techniques and Radiation Safety -- -- Radiologic Techniques in the Intensive Care Unit / C. Schaefer-Prokop ; Radiation Exposure and Radiation Safety / A. Stadler ; Communication, Reporting of Findings, and Teleradiology / M. Walz and C. Schaefer-Prokop -- -- 2. Thoracic Imaging of the Intensive Care Patient -- -- Technique of Portable Chest Radiography / C. Schaefer-Prokop ; Communication between Radiologists and Clinicians / C. Schaefer-Prokop ; Catheters and Monitoring Devices / E. Eisenhuber-Stadler and P. Wunderbaldinger ; Pulmonary Hemodynamics and Edema in ICU Patients / S. Metz-Schimmerl and C. Schaefer-Prokop ; Adult Respiratory Distress Syndrome / I. Noebauer-Huhmann, L. Kramer, and C. Schaefer-Prokop ; Pneumonia / C. Schaefer-Prokop and E. Eisenhuber-Stadler ; Atelectasis / Eisenhuber-Stadler ; Pneumothorax / E. Eisenhuber-Stadler and S. Metz-Schimmerl ; Pleural Effusion / C. Schaefer-Prokop ; Acute Pulmonary Embolism / S. Metz-Schimmerl and C. Schaefer-Prokop -- -- 3 Imaging of Intensive Care Patients after Thoracic Surgery / M. Fuchsjaeger and C. Schaefer-Prokop -- -- 4. Acute Abdomen in Intensive Care Patients -- -- Acute Pancreatitis / M. Uffmann ; Acute Cholecystitis and Cholangitis / M. Uffmann ; Acute (Pyelo)nephritis (Urosepsis) / G. Heinz-Peer ; Acute Renal Failure / G. Heinz-Peer ; Acute Gastrointestinal Bleeding / C. Loewe, E. Schober, and M. Ceijna ; Inflammatory Bowel Diseases / E. Schober and C. Schaefer-Prokop ; Acute Intestinal Ischemia / W. Schima and M. Prokop.
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  • "Get the most out of your study and review with Critical Care Secrets! This easy-to-read book uses the popular and trusted Secrets Series® question-and-answer format to cover all areas of critical care medicine, focusing on the practical, "in-the-trenches" know-how you need to succeed both in practice, and on board and recertification exams. The easy-to-read approach of the Secrets books has been serving medical professionals for decades."--Publisher's website.
  • Airway management -- Oxygenation without intubation -- Blood gas sampling -- Hemodynamic monitoring -- Drainage tube management -- Cardiac pacing and defibrillation -- Enteral feeding tubes -- Common procedures in the intensive care unit: thoracentesis, lumbar puncture, paracenetsis, and pericardiocentesis -- Noninvasive monitoring in the intensive care unit -- Endoscopy in the intensive care unit -- Radiologic imaging in the critically ill patient -- Critical care research and regulatory compliance -- Nursing care in the intensive care unit setting: the role of the nurse in the ICU -- Transport of critically ill patients -- Respiratory failure -- Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) -- Management of massive pulmonary embolism -- Heart failure -- Cardiac arrhythmias -- Gastrointestinal hemorrhage -- Acute liver failure -- Acute renal injury -- Sepsis syndromes -- Bleeding diathesis -- Nutrition assessment and nutrition therapy in intensive care unit patients -- Oxygen content, delivery, and uptake -- Circulatory shock -- Critical care neurology -- Neuromyopathies in the critically ill -- Neurosurgical emergencies -- Disorders of thermoregulation -- Infections in the intensive care unit -- Critical care endocrinology -- Evaluation and management of toxicological emergencies -- Metabolic disturbances of acid-base and electrolytes -- Special problems in the critically ill trauma patient -- Ethics in critical care -- Psychological dysfunction in the intensive care unit patient -- Host defenses -- Burn critical care -- ICU care of the solid organ transplant recipient -- Postoperative care of the cardiac surgery patient -- Obstetrical care in the ICU patient -- Modes of mechanical ventilation: part I -- Mechanical ventilation: part II: monitoring of respiratory mechanics during mechanical ventilation and ventilator strategies -- Noninvasive ventilation -- Weaning from mechanical ventilation -- Mechanical hemodynamic support -- Pharmacologic hemodynamic therapy of shock -- Advanced cardiopulmonary resuscitation -- Antiarrhythmic drug management -- Acute coronary syndromes -- Hypertensive crisis -- Dialysis -- Use of blood components -- Antimicrobials -- Use of analgesics and sedatives in critical care -- Use of neuromuscular blocking agents in the intensive care unit -- Prophylactic regimens in the intensive care unit -- Rehabilitation in the intensive care unit.
  • Critical care ultrasound 2015
    For physicians and nurses in critical care medicine, the increased demand and use of ultrasound necessitates further training. Critical Care Ultrasound helps meet that need. A straightforward, practical approach, an abundance of detailed ultrasound images, and online video demonstrations provide step-by-step guidance on the principles and effective use of this important imaging modality in both diagnosis and assistance with specific procedures. Coverage includes the latest applications of ultrasound for neurologic critical care; vascular problems; chest; hemodynamic monitoring; and abdominal and emergency uses, as well as assistance in a variety of specific procedures in critical care medicine.
  • Critical Care Ultrasound Manual is a concise step-by-step guide on the assessment of ultrasounds. It trains critical care physicians in applying Rapid Assessment by Cardiac Echo (RACE) and Focused Assessment with Sonography in Trauma (FAST) to sonography principles. Animated video clips of procedures assist the reader in comprehending the content covered in the manual. Focus on helping readers obtain rapid practical information to assist management decisions.User-friendly layout.Explanatory diagrams, ultrasound images enhance the learning experience. Practical tips and cautions are highlighted in Boxes. MCQs on each chapter allow readers to analyse what they've learnt. The Appendices provide a checklist to assist interpretation of transthoracic echocardiogram in a systematic way, and a chapter on Doppler principles for those who wish to prepare the way for Doppler measurements.
  • 1. Introduction -- 2. Themes and schemes: a prelude -- 3. At the beginning and end of life: a meditation on the subtle hoax of matter -- 4. Dialogue and trust -- 5. Openings into clinical ethics -- 6. Voices and time -- 7. Responsibility in clinical ethics consultation -- 8. Clinical listening, narrative writing -- 9. Visions and re-visions: life and the accident of birth.
  • Print Material
    The segmental approach to congenital heart disease -- Cardiovascular physiology and shock -- Regulation of pulmonary vascular resistance and blood flow -- Renal function and heart disease -- Splanchnic function and heart disease -- Cerebral function and heart disease -- Pharmacology of cardiovascular drugs -- Pediatric arrhythmias -- Pericardial effusion and tamponade -- Anesthesia for pediatric cardiac surgery -- Applied respiratory physiology -- Respiratory support for the child with critical heart disease -- Cardiac arrest and cardiopulmonary resuscitation -- Coagulation disorders in congenital heart disease -- Nutrition and metabolism in the critically ill child with cardiac disease -- Heart and lung transplantation -- Noninvasive diagnosis of congenital and acquired pediatric heart disease -- Diagnostic and therapeutic catheterization -- Perioperative monitoring -- Cardiopulmonary bypass in infants and children -- Mechaincal circulatory support in infants and children -- Nursing care of the child with congenital heart disease -- Perioperative management of patients with congenital heart disease: a multidisciplinary approach -- Atrial septal defects and ventricular septal defects -- Atrioventricular septal defects -- Left ventricular outflow tract obstruction -- Coarctation of the aorta and interrupted aortic arch -- Mitral valve diseases -- Aortopulmonary septal defects and patent ductus arteriosus -- Anomalous origin of the coronary arteries -- Persistent truncus arteriosus -- Total anomalous pulmonary venous return -- Transposition of the great arteries and the arterial switch operation -- Double-outlet right ventricle and double-outlet left ventricle -- Tetralogy of fallot with and without pulmonary atresia -- Pulmonary atresia with intact ventricular septum -- Ebstein's malformation -- Single-ventricle lesions -- Tricuspid atresia -- Hypoplastic left heart syndrome -- Separating the circulations: cavopulmonary connections (bidirectional glenn, hemi-fontan) and the modified fontan operation -- The critical appraisal and use of evidence about therapy -- Pulmonary hypertension -- Inflammatory heart disease -- Infective endocarditis -- Syndromes and congenital heart defects -- Heritable heart disease as part of multisystem illness -- Cardiomyopathy.
  • Section I. Innovation and process considerations in the role of IS/IT in e-health. -- 1. Improving e-performance management in healthcare using intelligent IT solutions / Fatemeh Hoda Moghimi and Nilmini Wickramasinghe -- 2. An intelligence e-risk detection model to improve decision efficiency in the context of the orthopaedic operating room / Fatemeh Hoda Mogihim, Hossein Zadeh, and Nilmini Wickramasinghe -- 3. Healthcare information systems design : using a strategic improvisation model / Say Yen Teoh and Nilmini Wickramasinghe -- 4. Assimilation of healthcare information systems (HIS) : an analysis and critique / Hidayah Sulaiman and Nilmini Wichramasinghe -- 5. e-health in China : an evaluation / Yu Yun ... [et al.] -- 6. Improving the process of healthcare delivery in an outpatient environment : the case of a urology department / Chris Gonzalez and Nilmini Wickramasinghe -- 7. Adaptations for e-kiosk systems in Germany to develop barrier-free terminals for handicapped persons / Manuel Zwicker, Juergen Seitz, and Nilmini Wichramasinghe -- Section II. Design and organisation designing supportive and collaborative electronic health environments. -- 8. Collaborative approach for sustainable citizen-centered health care / Pirkko Nykänen and Antto Seppäla ̈-- 9. Strategies and solutions in e-health : a literature review / Marco De Marco, Francesca Ricciardi, and Jan vom Brocke -- 10. Online discussion forum as a means of peer support / R. Halonen -- 11. Designing persuasive health behavior change interventions / Tuomas Lehto -- 12. Accessiblility in the web for disabled people / Irene Krebs, Arnim Nethe, and Reetta Raitoharju -- Section III. The importance of people in e-health : lest we forget. -- 13. Knowledge management : often neglected but crucial to ehealth / Juerg P. Bleuer ... [et al.] -- 14. Patient Empowerment : a two way road / Lodewijk Bos -- 15. Citizen empowerment / Amir Hannan -- 16. E-health : focusing on people-centric dimensions / Rajeev K. Bali ... [et al.] -- 17. A model of estimating the direct benefits of implementing electronic data exchange of EMRs and state immunization information systems / Michael L. Popovich and Xiaohui Zhang -- Section IV. Innovation in e-health. -- 18. Business models for electronic healthcare services in Germany / S. Duennebeil, J. Leimeister, and H. Krcmar -- 19. Smart objects in healthcare : impact on clinical logistics / Martin Sedlmayr and Ulli Münch -- 20. Agency theory in e-healthcare and telemedicine : a literature study / Joerg Leukel ... [et al.] -- 21. Cost accounting and decision support for healthcare institutions / L. Waehlert, A. Wagner, and H. Czap -- 22. A comprehensive approach to the IT : clinial practice interface / David Zakim and Mark Dominik Alscher
  • Goals, design, and implementation of critical pathways in cardiovascular medicine / Christopher P. Cannon and Patrick O'Gara -- Part I. -- Prehospital critical pathways -- Prehospital fibrinolysis / Freek W.A. Verheught -- Regional transfer programs for primary PCI / David M. Larson and Timothy D. Henry -- Public access defibrillation / Joseph P. Ornato -- Part II. -- Critical pathways in the emergency department -- Non-ST elevation ACS in the emergency department / Richard J. Ryan, Christopher P. Cannon, and W. Brian Gibler -- Thrombolysis for ST-elevation mi in the emergency department / Joshua M. Kosowsky -- Heart failure in the emergency department / W. Frank Peacock -- Atrial fibrillation in the emergency department / Ray Bahr -- Stroke and TIA / Lee Schwamm -- The Role of exercise testing in chest pain units: evolution, application, results / Ezra A. Amsterdam, Deborah B. Diercks, and Samuel D. Turnipseed -- Part III -- Critical pathways in the hospital -- Critical pathway for non-ST elevation ACS / Christopher P. Cannon and Patrick T. O'Gara -- Primary PCI / Amr E. Abbas and Cindy L. Grines -- Primary PCI at community hospitals without on-site cardiac surgery / Nancy Sinclair and Thomas P. Wharton, Jr. -- Approach to the patient with complicated myocardial infarction / Richard C. Becker -- Cardiac catheterization and percuraneous coronary intervention / Jeffrey J. Popma -- Pathways for coronary artery bypass surgery / Rashid M. Ahmad, Frances Wadlington, Tiffany Street, James P. Greelish, Jorge M. Balaguer, and John G. Byrne -- Acute aortic syndromes / Piotr Sobieszcyk and Patrick O'Gara -- Intensive management of hyperglycemia in ACS / Vera T. Fajtova -- Management of atrial fibrillation and atrial flutter / Eyal Herzog and Jonathan S. Steinberg -- Heart failure / Greg Fonarow -- Device therapy in patients with heart failure / Peter J. Zimetbaum and Eli V. Gelfand -- Venous thromboembolism / Samuel Z. Goldhaber -- Part IV. -- Critical pathways in the outpatient setting / -- Hyperlipidemia / Frederick F. Samaha and Daniel J. Rader -- Diabetes and metabolic syndrome / Emily Deborah Szmuilowicz and Merri Pendergrass -- Hypertension / Michael A. Weber -- Smoking cessation / Beth C. Bock -- Secondary prevention overview / Sidney Smith -- Overview of the AHA "get with the guidelines" programs / Yuling Hong, Kenneth A. LaBresh -- Cardiac rehabilitation in the post myocardial infarction patient / Daniel E. Forman.
  • Etiology / Marzia Marrollo, Alessandro Armuzzi and Fabio Zannoni -- Epidemiology / Marina Rizzi -- Genetics / Marco Castori and Paola Grammatico -- The Role of the Pathologist in the Management of Patients with Crohn's Disease / Roberto Pisa, Maria Cristina Macciomei and Alvaro Leone -- Clinical Presentation / Anna Kohn, Caterina Maria Camastra, Rita Monterubbianesi and Marina Rizzi -- Diagnostic and Therapeutic Role of Endoscopy / Arnaldo Andreoli, Patrizia Meddi, Paolo Pantanella and Antonio Tesi -- Laboratory Tests / Giuseppe Famularo and Giovanni Minisola -- Imaging / Loredana Adami, Maurizio Atzori, Paola Cerro, Andrea Cortese and Pasquale Ialongo, et al. -- Diagnosis of Anorectal Disease / Pasquale Ialongo, Loredana Adami, Maurizio Atzori, Cesare Hassan and Andrea Cortese, et al. -- Role of Interventional Radiology / Francesco Colucci, Paolo Agresti, Stefano Pieri, Maurizio Morucci and Lorenzo de' Medici -- Standard Therapeutic Approach / Roberto Mangiarotti -- New Therapies / Maria Lia Scribano and Maria Laura Annunziata -- Cell and Stem-Cell Therapies of Crohn's Disease and Complications / Luca Pierelli, Sergio Rutella and Giuseppina Bonanno -- Surgical Treatment / Roberto Tersigni -- Crohn's Disease in Children / Salvatore Cucchiara and Laura Stronati -- Perianal Disease / Luciano Alessandroni -- Crohn's Disease and Pregnancy / Claudio Donadio, Rocco Cosintino, Giuliano Rigon, Claudio Donadio and Fabrizio Signore -- Rheumatological Manifestations of Crohn's Disease / Giovanni Minisola and Giuseppe Famularo -- Cutaneous Manifestations / Luciano Alessandroni and Andrea Scotti -- Ocular Manifestations / Vincenzo Petitti and Stefano Tamburi -- Hepatopathologies / Leone Nauri -- Infectious Complications / Nicola Petrosillo and Cecilia M. J. Drapeau -- Kidney Disease / Margherita Rosa and Salvatore Di Giulio -- Crohn's Disease and Cancer / Fabio Calabrò and Cora N. Sternberg -- Crohn's Disease and Malignant Lymphomas / Valerio Zoli, Anna Proia and Ignazio Majolino -- Psychological and Social Aspects / Susan Levenstein and Vilma Varvo.
  • "The conditions of Crohn's disease and ulcerative colitis are excellent examples of how the exponential growth of knowledge in biomedical science can make a remarkable impact on clinical practice and patient's quality of life. It has led to the development of unique novel immunomodulatory treatments. These are continuously being refined to treat not only the two original conditions in the gut, but the systemic immunologic illness with its associated extraintestinal disorders. New therapies are sometimes complex and associated with important risks requiring a deeper understanding of their molecular principles from clinicians. Crohn's Disease and Ulcerative Colitis serves as a unique combined resource for physicians and scientists addressing the needs of both groups. It will stimulate exchange and collaboration and shorten the path between discovery and application of new knowledge and also help clinicians understand new therapeutic concepts from their origins. This volume provides an introduction to mucosal immunology which forms the basis of modern immunotherapy. It also serves as a comprehensive guide to the current diagnostic modalities, including enhanced imaging techniques such as MRI and CT enterography, virtual colonoscopy, ultrasound, and endomicroscopy as well as conventional and complex immunomodulatory principles. Each chapter is written by experts in their field and includes the most up to date information. Crohn's Disease and Ulcerative Colitis will be of great value to gastroenterologists, surgeons, internists, pediatricians and gynecologists trainees, as well as all those involved in Crohn's disease, ulcerative colitis and related autoimmune disorders"--Provided by publisher.
  • 1. History of Crohn's Disease -- 2. Molecular and Genetic Factors in Crohn's Disease -- 3. Medical Therapy for Crohn's Disease: The Present -- 4. Medical Therapy: The Future -- 5. Diagnosti Fluoroscopy for Imaging Crohn's Disease -- 6. Diagnostics: Body Imaging -- 7. Diagnostics: Endoluminal -- 8. Ultrasound -- 9. Diagnostics: The Future -- 10. Surgery: Small Intestine Terminal Ileum- Resection -- 11. Bowel Sparing Procedures in Crohn's Disease of the Small Instestine -- 12. Surgery: Colon -- 13. Surgery: Perineum -- 14. Perineal Reconstruction in Crohn's Disease -- 15. Surgery: Surgical Quality -- 16. Recurrent CD: Medical Prophylaxis -- 17. Recurrent CD: Surgical Prophylaxis- Kono-S Anastomosis -- 18. Recurrent Crohn's Disease: Surgical Treatment -- 19. Extraintestinal Manifestations of Crohn's Disease -- 20. Enterostomal Therapy in the Management of the Patient with Crohn's Disease -- 21. Diet and Nutrition in the Treatment of Crohn's Disease -- 22. Fertility/Sexual Function -- 23. Quality of Life in Patients with Crohn's Disease -- Index.
  • 1. Etiology and clinical features of Crohn's Disease -- 2. Pathological consideration in Crohn's Disease -- 3. The Role of endoscopy in the diagnosis and management of Crohn?s Disease -- 4. Capsule Endoscopy in the Evaluation of Crohn?s disease -- 5.Role of CTE/Enteroclysis in Crohn?s Disease -- 6. Ultrasonography in Crohn?s disease -- 7. CT and Magnetic Resonance enterography in Crohn?s disease -- 8. MR enteroclysis in Crohn?s disease -- 9. Radiological Assessment of Crohn?s Disease ? Current status and recent advances.- 10. Paediatric Crohn?s disease -- 11. Surgical management of Crohn?s disease -- 12. Overview of Medical management of Crohn?s disease.
  • This book offers concise descriptions of cross-sectional imaging studies of the abdomen and pelvis, supplemented with over 1100 high-quality images and discussion of state-of-the-art techniques. It is based on the most common clinical cases encountered in daily practice and uses an algorithmic approach to help radiologists arrive first at a working differential diagnosis and then reach an accurate diagnosis based on imaging features, which incorporate clinical, laboratory, and other underlying contexts. The book is organized by anatomical organ of origin and each chapter provides a brief anatomical background of the organ under review; explores various cross-sectional imaging techniques and common pathologies; and presents practical algorithms based on frequently encountered imaging features. Special emphasis is placed on the role of computed tomography (CT) and magnetic resonance imaging (MRI). In addition to algorithmic coverage of many pathological entities in various abdominopelvic organs, unique topics are also examined, such as imaging of organ transplant (including kidney, liver and pancreas), evaluation of perianal fistula, and assessment of rectal carcinoma and prostate carcinoma by MRI. Cross-Sectional Imaging of the Abdomen and Pelvis: A Practical Algorithmic Approach is a unique and practical resource for radiologists, fellows, and residents.
  • Signal transduction in DC differentiation: winged messengers and Achilles' heel / Inna Lindner ... [et al.] -- Shaping naive and memory CD8+ T cell responses in pathogen infections through antigen presentation / Gabrielle T. Belz ... [et al.] -- Understanding the role of innate immunity in the mechanism of action of the live attenuated yellow fever vaccine 17D / Troy D. Querec and Bali Pulendran -- The function of local lymphoid tissues in pulmonary immune responses / Juan Moyron-Quiroz ... [et al.] -- The yin and yang of adaptive immunity in allogeneic hematopoietic cell transplantation: donor antigen-presenting cells can either augment or inhibit donor T cell alloreactivity / Jian-Ming Li and Edmund K. Waller -- It's only innate immunity but I like it / Emanuela Marcenaro ... [et al.] -- Innate tumor immune surveillance / Mark J. Smyth, Jeremy Swann, and Yoshihiro Hayakawa -- Regulation of adaptive immunity by cells of the innate immune system: bone marrow natural killer cells inhibit T cell proliferation / Prachi P. Trivedi ... [et al.] -- Induction and maintenance of CD8+ T cells specific for persistent viruses / Ester M.M. van Leeuwen, Ineke J.M. ten Berge, and René A.W. van Lier -- Germinal center-derived B cell memory / Craig P. Chappell and Joshy Jacob -- CD28 and CD27 costimulation of CD8+ T cells: a story of survival / Douglas V. Dolfi and Peter D. Katsikis -- CD38: an ecto-enzyme at the crossroads of innate and adaptive immune responses / Santiago Partida Sánchez ... [et al.] -- Vascular leukocytes: a population with angiogenic and immunosuppressive properties highly represented in ovarian cancer / George Coukos ... [et al.] -- CD4+ T cells cooperate with macrophages for specific elimination of MHC class II-negative cancer cells / Alexandre Corthay -- Receptors and pathways in innate antifungal immunity: the implication for tolerance and immunity to fungi / Teresa Zelante ... [et al.].
  • Protective effects of type1 interferon in models of intestinal inflammation / Jongdae Lee ... [et al.] -- NK/DC complot / Emanuela Marcenaro ... [et al.] -- Detection of microbes by natural killer T cells / Yuki Kinjo, Mitchell Kronenberg -- Ontogeny of the secondary antibody response, origins and clonal diversity / Craig P. Chappell, Joseph Dauner, Joshy Jacob -- Role of PI3K signalling in the B cell response to antigen / Daniel J. Hodson, Martin Turner -- CD28, old dog, new tricks / Jayakumar R. Nair, Cheryl Rozanski, Kelvin P. Lee -- Initial TCR transgenic precursor frequency alters functional behaviour of CD8 T cells responding to acute infection / Thomas Wirth, John T. Harty -- Effects of cancer immunotherapy regimens on primary vs. secondary immune responses and the potential impact on long-term antitumor responses / Kory L. Alderson, William J. Murphy -- New insights into classical costimulation of CD8+ T cell responses / Christine M. Bucks, Peter D. Katsikis -- Peripheral tolerance induction by lymph node stroma / Erika D. Reynoso, Je-Wook Lee, Shannon J. Turley.
  • Is transcription the dominant force during dynamic changes in gene expression? -- MicroRNAs: key components of immune regulation -- KIR/HLA: genetic clues for a role of NK cells in the control of HIV -- Natural killer cell licensing during viral infection -- Bridging innate NK cell functions with adaptive immunity -- Control of innate immunity by memory CD4 T cells -- Strategies and implications for prime-boost vaccination to generate memory CD8 T cells -- Blimp1: driving terminal differentiation to a T -- New role for myeloid HO-1 in the innate to adaptive crosstalk and immune homeostasis -- Impact of differential glycosylation on IgG activity -- Murine model of chronic respiratory inflammation -- Incorporation of innate immune effector mechanisms in the formulation of a vaccine against HIV-1 -- Influenza vaccines: what do we want and how can we get it?
  • 1. Type III interferons (IFNs): emerging master regulators of immunity -- 2. Stability of regulatory T cells undermined or endorsed by different type-1 cytokines -- 3. The role of Il-12 and type I interferon in governing the magnitude of CD8 T cell responses -- 4. Functional diversity of human dendritic cells -- 5. Selective dependence of kidney dendritic cells on CX₃CR1, implications for glomerulonephritis therapy -- 6. Mechanisms of memory T cell activation and effective immunity -- 7. Molecular programming of immunological memory in natural killer cells -- 8. Induction of immune tolerance to dietary antigens -- 9. The role of p110ð in the development and activation of B lymphocytes -- 10. Immune memory and exhaustion: clinically relevant lessons from the LCMV model -- Index.
  • If you know all of the concepts in Crush Step 1: The Ultimate USMLE Step 1 Review, you should do much better than pass USMLE Step 1: You should Crush it! Led by Theodore X. O'Connell, MD, the author of the USMLE Step 2 Secrets and Brochert's Crush Step 2, this focused, high-yield review of core content and test prep strategies is the most effective USMLE Step 1preparation available for this high-stakes exam. Written and reviewed by students, residents, and experts!
  • With its focused review of common cases, high-yield content, and test prep strategies, Dr. Mayur K. Movalia's new review book offers the most effective preparation available for this high-stakes exam. Zero in on the content you need to know, thanks to a concise, consistent presentation for each case that is updated to mirror the 2013 USMLET software. Find the information you need quickly with a detailed index that organizes cases by symptom, final diagnosis, and specialty. Get up-to-date management strategies for CCS cases, thanks to input from a Resident Review Board comprised of high-scoring individuals (90th percentile or more), who evaluated the book to ensure its relevance and accuracy. Use it in conjunction with Brochert's Crush Step 3: The Ultimate USMLE Step 3 Review, 4th Edition for a comprehensive and highly effective Step 3 review. Get a 24-hour free trial to the USMLE Consult Step 3 CCS Case Bank, with a discount towards its purchase! 100 CCS cases simulate the actual USMLE Step 3 CCS experience.
  • Historical perspective. 3D reconstruction from electron micrographs: a personal account of its development / David DeRosier -- Chapter 1. Preparation of 2D crystals of membrane proteins for high-resolution electron crystallography data collection / Priyanka D. Abeyrathne ... [et al.] -- Chapter 2. Helical crystallization of soluble and membrane binding proteins / Elizabeth M. Wilson-Kubalek, Joshua S. Chappie, Christopher P. Arthur -- Chapter 3. Plunge freezing for electron cryomicroscopy / Megan J. Dobro ... [et al.] -- Chapter 4. A Practical guide to the use of monolayer purification and affinity grids / Deborah F. Kelly, Danijela Dukovski, Thomas Walz -- Chapter 5. GraFix: stabilization of fragile macromolecular complexes for single particle cryo-EM / Holger Stark -- Chapter 6. Cryonegative staining of macromolecular assemblies / Sacha De Carlo, Holger Stark -- Chapter 7. Liposomes on a streptavidin crystal: a system to study membrane proteins by cryo-EM / Liguo Wang, Fred J. Sigworth -- Chapter 8. Micromanipulator-assisted vitreous cryosectioning and sample preparation by high-pressure freezing / Mark S. Ladinsky -- Chapter 9. Site-specific biomolecule labeling with gold clusters / Christopher J. Ackerson, Richard D. Powell, James F. Hainfeld -- Chapter 10. How to operate a cryo-electron microscope / Jingchuan Sun, Huilin Li -- Chapter 11. Collecting electron crystallographic data of two-dimensional protein crystals / Richard K. Hite ... [et al.] -- Chapter 12. Automated data collection for electron microscopic tomography / Shawn Q. Zheng, J.W. Sedat, D.A. Agard -- Chapter 13. Correlated light and electron cryo-microscopy / Ariane Briegel ... [et al.] -- Chapter 14. Phase plates for transmission electron microscopy / Radostin Danev, Kuniaki Nagayama -- Chapter 15. Radiation damage in electron cryomicroscopy / Lindsay A. Baker, John L.
  • Chapter 1. Fundamentals of three-dimensional reconstruction from projections / Pawel A. Penczek -- Chapter 2. Image restoration in cryo-electron microscopy / Pawel A. Penczek -- Chapter 3. Resolution measures in molecular electron microscopy / Pawel A. Penczek -- Chapter 4. 3D reconstruction from 2D crystal image and diffraction data / Andreas D. Schenk ... [et al.] -- Chapter 5. Fourier-Bessel reconstruction of helical assemblies / Ruben Diaz, William J. Rice, David L. Stokes -- Chapter 6. Reconstruction of helical filaments and tubes / Edward H. Egelman -- Chapter 7. Three-dimensional asymmetric reconstruction of tailed bacteriophage / Jinghua Tang, Robert S. Sinkovits, Timothy S. Baker -- Chapter 8. Single particle analysis at high resolution / Yao Cong, Steven J. Ludtke -- Chapter 9. The Orthogonal tilt reconstruction method / Andres Leschziner -- Chapter 10. An Introduction to maximum-likelihood methods in cryo-EM / Fred J. Sigworth ... [et al.] -- Chapter 11. Classification of structural heterogeneity by maximum-likelihood methods / Sjors H.W. Scheres -- Chapter 12. Methods for three-dimensional reconstruction of heterogeneous assemblies / Elena V. Orlova, Helen R. Saibil -- Chapter 13. Alignment of cryo-electron tomography datasets / Fernando Amat ... [et al.] -- Chapter 14. Correcting for the Ewald sphere in high-resolution single-particle reconstructions / Peter A. Leong ... [et al.] -- Chapter 15. Software tools for molecular microscopy: an open-text wikibook / Neil R. Voss ... [et al.].
  • Chapter 1. Analyses of subnanometer resolution cryo-EM density maps / Matthew L. Baker ... [et al.] -- Chapter 2. Methods for segmentation and interpretation of electron tomographic reconstructions / Niels Volkmann -- Chapter 3. Integration of cryo-EM with atomic and protein-protein interaction data / Friedrich Förster, Elizabeth Villa -- Chapter 4. Unified data resource for cryo-EM / Catherine L. Lawson -- Chapter 5. Electron crystallography and aquaporins / Andreas D. Schenk ... [et al.] -- Chapter 6. Cryoelectron microscopy applications in the study of tubulin structure, microtubule architecture, dynamics and assemblies, and interaction of microtubules with motors / Kenneth H. Downing, Eva Nogales -- Chapter 7. Helical crystallization of two example membrane proteins: MsbA and the Ca2+-ATPase / John Paul Glaves ... [et al.] -- Chapter 8. Multiparticle cryo-EM of ribosomes / Justus Loerke, Jan Giesebrecht, Christian M.T. Spahn -- Chapter 9. Single-particle electron microscopy of animal fatty acid synthase: describing macromolecular rearrangements that enable catalysis / Edward J. Brignole, Francisco Asturias -- Chapter 10. Tomography of actin cytoskeletal networks / Dorit Hanein -- Chapter 11. Visual proteomics / Friedrich Förster, Bong-Gyoon Han, Martin Beck -- Chapter 12. Cryoelectron tomography of eukaryotic cells / Asaf Mader, Nadav Elad, Ohad Medalia -- Chapter 13. 3D visualization of HIV virions by cryoelectron tomography / Jun Liu, Elizabeth R. Wright, Hanspeter Winkler -- Chapter 14. Automation in single-particle electron microscopy: connecting the pieces / Dmitry Lyumkis ... [et al.].
  • 2011 ClinicalKey
    History of cardiac cryosurgery and cryoablation / Daniel L. Lustgarten -- Mechanisms of cryoablation / Kristi K. Snyder ... [et al.] -- Factors that determinine cryolesion formation and cryolesion characteristics / Audrius J. Bredikis and David J. Wilber -- Canine model of esophageal injury during atrial fibrillation ablation : comparison of cryothermal, radiofrequency, and ultrasound ablation injury / Hiroshi Nakagawa ... [et al.] -- Cryoablation effects on pulmonary veins in experimental settings / Mauricio Arruda ... [et al.] -- Cryoablation effects on coronary arteries and veins / Audrius J. Bredikis -- Medtronic cryocath technology / Jeffrey Silver ... [et al.] -- Boston scientific technology / Victoria Carr-Brendel and Joann Heberer -- Evolving concepts : near-critical cooling-based technologies / Peter J. Littrup and Alex Babkin -- Reversible effects of cryoablation and atrioventricular node modification / Frédéric Franceschi, Marc Dubuc, and Paul Khairy -- AVNRT cryoablation and comparison with RF ablation / Luc Jordaens ... [et al.] -- Cryoablation of septal accessory pathways / Felipe Atienza and Jesus Almendral -- Cryoablation of atrial flutter / Peter S. Andrew and Annibale S. Montenero -- Focal cryoablation of atrial fibrillation / Chung-Wah Siu and Hung-Fat Tse -- Balloon-based cryoablation of atrial fibrillation / Thomas Neumann and Malte Kuniss -- Cryocatheter ablation of ventricular tachycardia / Heinz T. Pitschner and Damir Erkapic -- Role of cryoablation for superior vena cava isolation and ablation of inappropriate sinus tachycardia / John Roshan ... [et al.] -- Cryoablation in pediatrics / Bryan Canon -- Endocardial cryoablation of atrial fibrillation / Fiorenzo Gaita ... [et al.] -- Cryosurgery for ventricular tachycardia / Jean-Marc Frapier ... [et al.].
  • Cryocoolers 13 2005
  • This book aims to fill the gap created by the lack of formal training in cryosurgery, which leads not only to an underutilization of the technique but also to inappropriate uses with unpleasant consequences for patients. The book covers all practical aspects of cryosurgery and also offers a theoretical foundation for practice. Basic principles, equipment, and techniques are described, and procedures are explained step by step for a range of applications, including common benign lesions, vascular lesions, premalignant conditions, and malignancies. An important feature is the coverage of the latest advances in combination treatments such as topical drugs and cryosurgery, ultrasound and cryosurgery, photography and cryosurgery, cryobiopsy, and immunocryosurgery. Use of cryosurgery as palliative treatment is also discussed, and the closing chapters consider postoperative care, complications, and future directions.
  • General biology / Ronald Fayer -- Genomics / Jessica C. Kissinger -- Biochemistry / Guan Zhu -- Epidemiology / Gordon Nichols -- Molecular epidemiology / Lihua Xiao and Una M. Ryan -- Diagnostics / Huw Smith -- Immune responses / Vincent McDonald -- Clinical disease and pathology / Cirle Alcantara Warren and -- Richard l. Guerrant -- Prophylaxis and chemotherapy / Heather D. Stockdale, Jennifer A. Spencer, and Byron L. Blagburn -- Foodborne transmission / Ynes R. Ortega and Vitaliano A. Cama -- Waterborne: drinking water / Jennifer L. Clancy and Thomas M. Hargy -- Waterborne: recreational water / Michael Beach -- Waste management / Dwight D. Bowman -- Fish, amphibians and reptiles / Thaddeus Graczyk -- Birds / Una Ryan and Lihua Xiao -- Zoo and wild mammals / Olga Matos -- Companion animals / Mónica Santín and James M. Trout -- Livestock / Mónica Santín and James M. Trout -- Animal models / Saul Tzipori and Giovanni Widmer -- In vitro cultivation / Michael J. Arrowood.
  • This new volume on Cryptosporidium and Cryptosporidiosis discusses all relevant aspects of the biology, molecular biology, host-parasite interaction, epidemiology as well as diagnosis and treatment of these widespread parasites. It represents a useful guide for physicians, microbiologists, veterinarians and water professionals seeking advanced knowledge and guidance about these important parasitic pathogens. A section on practical lab procedures discusses step-by-step guidelines for sample preparation and lab procedures. The new book may further serve as a reference work for graduate students in medical and veterinary microbiology.
  • Model and molecule. -- An overview of protein crystallography. -- Protein crystals. -- Collecting diffraction data. -- From diffraction data to electron density. -- Obtaining phases. -- Obtaining and judging the molecular model. -- A user's guide to crystallographic models. -- Other diffraction methods. -- Other kinds of macromolecular models. -- Tools for studying macromolecules. -- Appendix: Viewing stereo images.
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  • Principles of computed tomographic angiography -- Principles of magnetic resonance angiography -- Conventional angiography in the noninvasive era -- Contrast medium administration in computed tomographic angiography -- Contrast medium administration in magnetic resonance angiography -- Postprocessing and data analysis -- Atherosclerosis : epidemiology and pathology -- Atherosclerosis : in vivo characterization -- Thromboembolism -- Vasculitides and connective tissue disorders -- Cerebral arteries and veins -- Cervical vasculature -- Quantifying coronary artery calcium -- Coronary arteries -- Thoracic vascular anomalies -- Pulmonary vasculature -- Thoracic aorta -- Abdominal aorta -- Mesenteric vasculature -- Renal vasculature -- Lower extremities vasculature -- Upper extremities vasculature -- Pediatric techniques and vascular anomalies -- Venous system.
  • "Now in its Third Edition, this trusted and practical volume in LWW's Teaching File Series offers residents and practicing radiologists a unique opportunity to study alongside the experts in their field. For the first time, CT and MRI of the Abdomen and Pelvis is a hybrid publication, with a new paperback format and accompanying web content that includes a wealth of case studies users can access from their laptop, tablet, or mobile device. The book is useful both as a quick consult or study aid for anyone preparing for Board examinations in Radiology and other specialties where knowledge of CT and MRI of the abdomen and pelvis are required. This skill-builder delivers ... 416 structured case studies based on actual patients--each providing a brief patient history, as many as four CT/MR images, a short description of the findings, differential diagnosis, final diagnosis, and a discussion of the case. Detailed imaging of all areas of the abdomen and pelvis including the liver and biliary system, pancreas, GI tract, spleen, mesentery/omentum/peritoneum, kidney and urinary system retroperitoneum and adrenal glands and abdominal wall--helps readers understand relevant anatomy and identify pathologies. NEW to third Edition ... Hybrid format includes print and online components. 30% new cases address new challenges and provide timely information. Accompanying web site delivers access to all cases in the book, plus several hundred supplemental, "bonus" cases!"--Provided by publisher.
  • Part I. Cardiac embryology and the normal heart -- Cardiac embryology -- The normal heart -- Normal anatomic variants and imaging artifacts mimicking pathology -- Part II. Basic nomenclature and approach to evaluating congenital heart disease imaging -- Basic nomenclature in adult congenital heart disease -- Segmental, sequential approach to CT interpretation in adult congenital heart disease -- Part III. CT imaging techniques in adult congenital heart disease -- Part IV. Congenital dysplasias and cardiomyopathies -- Arrhythmogenic right ventricular dysplasia -- Uhl anomaly -- Left ventricular noncompaction (LVNC) -- Hypertrophic cardiomyopathy -- Part V. Anomalies with normal chamber and valve sequence and position -- Septal defects -- Atrioventricular valve abnormalities -- Left venntricular outflow tract abnormalities -- Right ventricular outflow tract obstruction -- Arterial anomalies -- Coronaryu artery anomalies -- Congenital venous anomalies -- Part VI. Anomalies with abnormal chamber sequence or relationship -- Abnormal relationship between the atria and ventricles -- Abnormal relationship between ventricles and great vessels -- Heterotaxy syndrome -- Part VII. Palliative and corrective procedures in adult congenital heart disease -- Percutaneous closures -- Aortopulmonary shunts: Blalock-Taussig, Potts, Waterston -- Atrial baffles for the treatment of transposition of the great artaeries (Mustard, Senning) -- Arterial switch operation for transposition of the great arteries -- Systemic vein to pulmonary artery shunts: Glenn, Fontan, and Kawashima procedures -- Rastelli procedure -- Damus-Kaye-Stansel procedure -- Double-switch procedure -- Ross procedure -- Norwood procedures and Sano modification -- Aortic coarctation repairs -- Part VIII. Congenital pericardial abnormmalites -- Congenital absence of the pericardium.
  • Normal colon -- Anatomical variants: positional anomalies of colon -- Pitfalls in imaging -- Diverticular disease -- Lipomatous lesions of the colon -- Inflammatory bowel disease -- Polyps: pedunculated -- Sessile polyps -- Flat lesion -- Colon cancer -- Rectal cancer -- The ileocecal valve -- Operated large bowel.
  • In CT Colonography, Perry Pickhardt and David Kim present techniques for quicker evaluation and diagnosis of colon cancer through the pioneering, specialty-changing imaging technique of virtual colonoscopy (VC). This combination of sophisticated X-rays and CT scans of the abdomen offers patients an alternative to colonoscopy that is cost effective and reduces the need for unnecessary polyp removal. Abundantly illustrated in full color, this pioneering book describes CT colonography from pathogenesis, staging and treatment through indications, technique, and interpretation for the most common pathologies. Covers principles, techniques, and interpretations for the most common pathologies in a logical, practical organization. Presents tips from the authors on setting up a VC practice to provide a personal, instructive guide. Provides over 1000 full-color, high-resolution anatomic images throughout for the clearest, most accurate picture of colorectal cancer, its natural history, and its diagnosis by VC. Focuses on images, with the text serving as context for the proper use and understanding of VC.
  • Structure: Coronary CT angiography {u2013} State of the Art -- Function: CT Assessment of global and regional cardiac function {u2013} State of the Art -- Perfusion: Why are we interested in myocardial perfusion -- CT evaluation of the myocardial blood supply: Technical options -- CT evaluation of the myocardial blood supply {u2013} Single-source, single-energy CT -- CT evaluation of the myocardial blood supply: Ultra-low radiation dose CT techniques -- CT evaluation of the myocardial blood supply: Dual-source dual-energy CT -- CT evaluation of the myocardial blood supply: Fast kV-switching dual-energy CT -- Dynamic, time-resolved CT imaging of myocardial perfusion: Dual-source CT -- Dynamic, time-resolved CT imaging of myocardial perfusion: 256-slice CT -- Dynamic, time-resolved CT imaging of myocardial perfusion: 320-slice CT -- CT assessment of the myocardial blood supply: Quantitative imaging -- Viability: Why are we interested in myocardial viability -- CT approaches for the assessment of myocardial viability -- CT imaging of myocardial viability: experimental and clinical evidence -- CT assessment of myocardial viability: Quantitative imaging -- Clinical Implementation: CT myocardial perfusion imaging: Clinical implementation -- Integrative imaging of coronary heart disease: Future perspectives -- Protocol recommendations.
  • CT of the airways 2008
  • CT of the heart: past, present, and future / William Stanford -- Electron beam CT of the heart / David G. Hill -- Scan techniques for cardiac and coronary artery imaging with multislice CT / Bernd M. Ohnesorge, Brian R. Westerman and U. Joseph Schoepf -- Image reconstruction for ECG-triggered and ECG-gated multi-slice CT / Thomas Flohr and Tinsu Pan -- Phase-correlated image reconstruction without ECG / Marc Kachelriess and Willi A. Kalender -- Radiation dose from CT of the heart / Cynthia H. McCollough -- Coronary calcium screening: an epidemiologic perspective / Christopher J. O'Donnell and Udo Hoffmann -- Coronary calcium scanning: why we should perform it / Axel Schmermund, Stefan Möhlenkamp and Raimund Erbel -- Detection and quantification of coronary calcium with electron beam CT -- Axel Schmermund, Stefan Möhlenkamp and Raimund Erbel -- Detection and quantification of coronary calcium with dual slice CT / Joseph Shemesh -- Detection and quantification of calcified coronary plaque with multidetector-row CT / J. Jeffrey Carr -- Coronary calcium scoring with multidetector-row CT: rationale and scoring techniques / Roman Fischbach and David Maintz -- Noninvasive quantification of coronary calcium: quantification methods, scanner types, scan protocols, accuracy, and reproducibility / Stefan Ulzheimer, Kaiss Shanneik and Willi A. Kalender -- CT of the pericardium / Reinhard Groell -- Multidetector-row CT for assessment of cardiac valves / Jürgen K. Willmann and Dominik Weishaupt -- Multislice CT of the heart and great vessels in congenital heart disease patients / Jean-François Paul -- Imaging of cardiac and paracardiac masses and pseudotumors / Bernd J. Wintersperger -- Multidetector-row CT assessment of left-ventricular function / Kai Uwe Juergens and Roman Fischbach -- Imaging intramyocardial microcirculatory function using fast computed tomography / Stefan Möhlenkamp ... [et al.] -- Approaches for assessing myocardial viability with multidetector-row CT / Yasushi Koyama and Teruhito Mochizuki -- Anatomy of the coronary arteries and veins in CT imaging / Robert J.M. van Geuns and Filipo Cademartiri -- Techniques and protocols for acquisition and display of contrast-enhanced CT coronary angiography / Christoph R. Becker -- Contrast material injection techniques for CT angiography of the coronary arteries / Filippo Cademartiri and Koen Nieman -- Visualization techniques for contrast-enhanced CT angiography of coronary arteries / Jean-Louis Sablayrolles and Pascal Giat -- CT angiography for assessment of coronary artery anomalies / Steffen C. Froehner ... [et al.] -- Multidetector-row CT for assessment of Kawasaki's disease / Toru Sakuma and Kunihiko Fukuda -- Multidectector-row CT of the coronary arteries for planning of minimally invasive bypass surgery / Christopher Herzog, Selami Dogan and Thomas J. Vogl -- CT angiography for assessment of coronary bypass grafts / Marcello De Santis -- Contrast-enhanced electron beam CT and multidetector-row CT in the evaluation of coronary stent patency / Heiko Pump ... [et al.] -- CT angiography for the detection of coronary artery stenosis / Koen Nieman and Filippo Cademartiri -- Complementary use of coronary calcium scoring and CT angiography / Alexander W. Leber -- CT vs magnetic resonance for imaging of the coronary arteries / Armin Huber -- Pathology and pathophysiology of coronary atherosclerotic plaques / Renu Virmani ... [et al.] -- Pathogenesis of the vulnerable atherosclerotic plaque / Masanori Aikawa -- Multidetector-row CT imaging of clinical and preclinical coronary atherosclerosis / Christoph R. Becker -- Multidetector-row CT vs intravascular ultrasound for coronary plaque characterization / Axel Kuettner -- Multidetector-Row CT vs magnetic resonance imaging for coronary plaque characterization / Konstantin Nikolaou, Christoph R. Becker, and Zahi Fayad -- Multidetector-row CT for detection of noncalcified and calcified coronary lesions: clinical significance / Stephen Schroeder.
  • This book provides a comprehensive and up-to-date overview of the continuously evolving field of dual-energy CT (DECT). An introductory section presents information on the physical and technical background of DECT and considers nonspecific and specific software advantages. Clinical applications of DECT in the evaluation of retroperitoneal viscera are then addressed in detail with the help of high-quality illustrations. Particular attention is devoted to the most recent DECT study protocols, software, and applications in aortic, renal, pancreatic, and adrenal disease. A number of case studies are reported that elucidate the advantages of DECT, and the relevant literature is extensively discussed. The book closes by considering radiation dose and dose-saving measures. The simple and practical approach offered by this book will assist radiologists in the optimal routine use and interpretation of DECT in different retroperitoneal sites and radiology technologists in the choice of settings and parameters.
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  • This book provides a comprehensive review of CT Virtual Hysterosalpingography, a new non-invasive diagnostic technique that allows the evaluation of the entire gynecologic tract in a single study, by combining the benefits of hysterosalpingography (HSG) with multidetector Computed Tomography (CT). The addition of 64-row CT scanners with HSG has significantly improved visualization and assessment of the uterine cavity and fallopian tubes, and allows for the diagnosis of polyps, myomas, uterine anomalies and tubal pathology with a high degree of accuracy. CT Virtual Hysterosalpingography is written and edited by the leaders in the field and covers all aspects of the technique, from its origin and technical principles through to descriptions of the normal anatomy and most common pathologies. This will be an essential text for Gynecologists, Infertility Specialists, Radiologists and Reproductive Endocrinologists who would want to learn about this technique and how it can be implemented in their practice.
  • Interventional radiology is an indispensable and still expanding area of modern medicine that encompasses numerous diagnostic and therapeutic procedures. Cross-sectional imaging modalities such as computed tomography (CT) and magnetic resonance (MR) have emerged as important techniques for non-vascular interventions, including percutaneous biopsy, drainage, ablation, and neurolysis. Various organs, diseases, and lesions can be approached in this way, permitting the treatment and management of tumors, fluid collections, and pain, the embolization of endoleaks, the provision of access to hollow organs, etc. Accordingly, interventional radiology is now an integral component of the interdisciplinary management of numerous disorders. The revised and significantly extended second edition of this volume covers a broad range of non-vascular interventions guided by CT or MR imaging. Indications, materials, techniques, and results are all carefully discussed. A particularly comprehensive section is devoted to interventional oncology as the most rapidly growing branch of interventional radiology. In addition, detailed information is provided that will assist in establishing and developing an interventional service. This richly illustrated book will be a most valuable source of information and guidance for all radiologists who deal with non-vascular procedures.
  • This report provides the IOM committee's findings and recommendations regarding the progress and potential of NIH's CTSA Program. The report covers the breadth of the statement of task and highlights opportunities to bolster the program and ensure its continued success and sustainability in supporting clinical and translational researchers and serving the needs of the communities CTSAs are linked to and in which they reside. Chapter 2 discusses the ecosystem in which NCATS and the CTSA Program operate and provides the committee's vision for the next phase of the CTSA Program. Chapter 3 emphasizes the need for strong and active leadership by NCATS in establishing a clear vision and mission for the program along with measurable goals; supporting individual CTSAs; partnering and collaborating within the NIH and with external partners; and evaluating and communicating the program's value. Chapter 4 highlights specific opportunities and priorities in the areas of training and education, community engagement, and research related to child health. On the basis of discussions, conclusions, and recommendations outlined in the preceding chapters, in Chapter 5 the report concludes with next steps and potential future directions.
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  • "Cultural Psychiatry with emphasis on its impact on etio-pathogenesis, diagnosis, clinical practice, preventive and research activities are topics discussed in this publication which give readers a general conceptual perspective of this field. Cultural aspects of psychiatric diagnosis in DSM-5 in particular and the current status of Cultural Psychiatry in European countries are discussed. Of unique importance to the field of psychosomatics are the reviews on so-called culture-bound syndromes and somatization and culture. Ethnopsychopharmacology, pharmacogenomics, current and future research perspectives in Cultural Psychiatry and bioethical dimensions of cultural psychosomatics are also reviewed. The volume closes with an epilogue and conclusions resulting from the examined topics. Psychiatrists, psychologists, social scientists and other mental health professionals involved in clinical practice and research groups as well as trainees and students will find that this publication provides a cogent perspective of current practice and research issues about a field that has enormous clinical relevance and which, until recently, has been systematically neglected"--Back cover.
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    1. Afghans -- 2. African Americans -- 3. American Indians/Alaskan natives -- 4. Arabs -- 5. Brazilians -- 6. Cambodians (Khmer) -- 7. Central Americans (Guatemalans, Nicaraguans, and Salvadorans) -- 8. Chinese -- 9. Colombians -- 10. Cubans -- 11. Dominicans -- 12. East Indians -- 13. Ethiopians and Eritreans -- 14. Filipinos -- 15. Germans -- 16. Greeks -- 17. Haitians -- 18. Hawaiians -- 19. Hmong -- 20. Iranians -- 21. Irish -- 22. Italians -- 23. Japanese -- 24. Koreans -- 25. Mexicans -- 26. Nigerians -- 27. Pakistanis -- 28. Polish -- 29. Puerto Ricans -- 30. Roma (Gypsies) -- 31. Russians and others from the former Soviet Union -- 32. Samoans -- 33. Vietnamese -- 34. West Indians/Caribbeans -- 35. (Former) Yugoslavians.
  • 1. The border region: its culture and health disparities -- 2. Understanding health disparities -- 3. A critique of U.S.-Mexico Border health interventions -- 4. Ethical issues in health interventions across contexts and cultures -- Index.
  • Cultural neuroscience combines brain imaging techniques such as functional magnetic resonance imaging and event-related brain potentials with methods of social and cultural psychology to investigate whether and how cultures influence the neural mechanisms of perception, attention, emotion, social cognition, and other human cognitive processes. The findings of cultural neuroscience studies improve our understanding of the relation between human brain function and sociocultural contexts and help to reframe the 'big question' of nature versus nurture.blications and an overview on his outstanding life.
  • Introduction : culture and well-being works by Ed Diener / Ed Diener -- Culture and subjective well-being / William Tov and Ed Diener -- Factors predicting the subjective well-being of nations / Ed Diener, Marissa Diener and Carol Diener -- Cross-cultural correlates of life satisfaction and self-esteem / Ed Diener and Marissa Diener -- Goals, culture and subjective well-being / Shigehiro Oishi and Ed Diener -- Cross-cultural variations in predictors of life satisfaction : perspectives from needs and values / Shigehiro Oishi, Ed Diener, Richard E. Lucas and Eunkook M. Suh -- From culture to priming conditions : self-construal infulences on life satisfaction judgments / Eunkook M. Suh, Ed Diener and John A. Updegraff -- The dynamics of daily events and being well across cultures : when less is more / Shigehiro Oishi, Ed Diener, Dong-Won Choi, Chu Kim-Prieto and Incheol Choi -- Norms for experiencing emotions in different cultures : inter- and intranational differences / Michael Eid and Ed Diener -- Emotions across cultures and methods / Christie Napa Scollon, Ed Diener, Shigehiro Ioshi and Robert Biswas-Diener -- Positivity and the contruction of life satisfaction judgments : global happiness is not the sum of its parts / Ed Diener, Christie Napa Scollon, Shigehiro Oishi, Vivian Dzokoto and Eunkook M. Suh -- Most people are pretty happy, but there is cultural variation : the Inughuit, the Amish and the Maasai / Robert Biswas-Diener, Joar Vittersø and Ed Dierner -- Making the best of a bad situation : satisfaction in the slums of Calcutta / Robert Biswas-Diener and Ed Diener -- Conclusion : what we have learned and where we go next / Ed Diener.
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    Culture care diversity and universality theory and evolution of the ethnonursing method / Madeleine M. Leininger -- Ethnonursing research method and enablers / Madeleine M. Leininger -- Globalization of transcultural nursing theory and research / Margaret Andrews -- Culture care of the Gadsup Akuna of the eastern highlands of New Guinea: first transcultural nursing study / Madeleine M. Leininger -- Clinical nursing aspects discovered with the culture care theory / Debra A. Curren -- Culture care of German American elders in a nursing home context / Madeleine M.. Mcfarland and Norma Zehnder -- Culture care of the Potawatomi Native Americans who experienced family violence / Linda S. Farrell -- Use of the culture care theory and as a framework for the recruitment, engagement, and retention of culturally diverse nursing students in a traditionally European American baccalaureate nursing program / Marilyn S. McFarland ... [et al.] -- Culture care theory with southern Sudanese of Africa / Madeleine M. Leininger -- Selected culture care findings of diverse cultures using culture care theory and ethnomethods / Madeleine M. Leininger -- Generic care of Lebanese Muslim women in the midwestern USA / Hiba Wehbeh-Alamah -- Culture care and health of Russian and Vietnamese refugee communities in the United States / Anna Frances Z. Wenger -- Application of the culture care theory for clinical nurse administrators and managers / Ann O. Hubbert -- Culture care theory and uses in nursing administration / Madeleine M. Leininger -- Synopses of classic research studies on Philippine and U.S. nurses and the culture care of dying patients in hospital and hospice / Madeleine M. Leininger -- Envisioning the future of culture care theory and the ethnonursing method / Madeleine M. Leininger.
  • During the recent transition between acute diseases caused by swarms of single planktonic bacteria, and chronic infections caused by bacteria growing in slime-enclosed biofilms, a general clinical consensus has emerged that pathologies with bacterial etiologies are frequently culture negative. Because biofilm infections now affect 17 million Americans per year (killing approximately 450,000), the suggestion that these common and lethal infections regularly go unnoticed by the only FDA-approved method for their detection and characterization is a matter of urgent concern. Biologically, we would expect that planktonic bacterial cells would colonize any new surface, including the surface of an agar plate, while the specialized sessile cells of a biofilm community would have no such proclivity. In the study of biofilm diseases ranging from otitis media to prostatitis, it was found that direct microscopy and DNA- and RNA-based molecular methods regularly document the presence of living bacteria in tissues and samples that are culture negative. The editors selected orthopedic biofilm infections as the subject of this book because these infections occur against a background of microbiological sterility in which modern molecular methods would be expected to find bacterial DNA, RNA-based microscopic methods would be expected to locate bacterial cells, and cultures would be negative. Moreover, in Orthopedics we find an already biofilm-adapted surgical group in which current strategies are based on the meticulous removal of compromised tissues, antibiotic options as based on high biofilm-killing local doses, and there are practical bedside strategies for dealing with biofilm infections. So here is where the new paradigm of biofilm infection meets the equally new paradigm of the culture negativity of biofilms, and this volume presents a conceptual synthesis that may soon combine the most effective molecular methods for the detection and identification of bacteria with a surgical discipline that is ready to help patients.
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  • Cummings Pediatric Otolaryngology is your indispensable source for definitive, state-of-the-art answers on every aspect of treating children with otorhinolaryngologic disorders. With a focus on the simple problems in children with comorbidities as well as complex clinical problems in healthy and complex children, this derivative title of Cummings Otolaryngology provides the essential information needed for practicing otolaryngologists to stay up-to-date on these evolving areas.
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    Acclimatization, climatology, and the possibility of empire -- Colonial hydrotherapy -- Highland hydrotherapy in Guadeloupe -- The spas of Réunion Island: antechambers to the tropics -- Leisure and power at the spa of Antsirabe, Madagascar -- Korbous, Tunisia: negating the hammam -- Vichy: taking the waters back home.
  • A concise guide to TB control / Stefan HE Kaufmann -- Unmet medical needs for diagnostics, drugs and vaccines / Syed Huq & Peter D.O. Davies -- TB diagnostics : current pipeline, new developments and unmet needs / Madhukar Pai, Samuel G. Schumacher, Hojoon Sohn & Claudia M. Denkinger -- Antituberculosis therapy and current global guidelines / Giovanni Battista Migliori, Giovanni Sotgiu, Rosella Centis, Malgorzata Grzemska, Dennis Falzon, Haileyesus Getahun & Mario C. Raviglione -- New therapeutics in development and future directions / Anna Upton & Zhenkun Ma -- New vaccines in development and future direction / Helen McShane & Rosalind Rowland.
  • Current and emerging therapeutics for multiple myeloma / Noopur Raje & Sundar Jagannath -- Current standard treatment of myeloma / Ray Powles & Arif Meghani -- Stem cell transplantation / Hermann Einsele -- New immune modulators / Loredana Santo & Noopur Raje -- Histone deacetylase inhibitors / Maurizio Zangari, Tamara Berno & Fenghuang Zhan -- Targeted treatment of multiple myeloma : proteasome inhibitors / Kristen M. Sanfilippo & Ravi Vij -- AKT inhibitors in multiple myeloma / R. Donald Harvey & Sagar Lonial -- Future directions / Klaus Podar -- Index.
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  • "Current Advances in Osteosarcoma summarizes molecular and genetic characteristics, new therapeutic ideas, and biological characteristics that have been uncovered in this field over the past 10 years. Osteosarcoma is an aggressive malignant neoplasm and is the most common histological form of bone cancer. Osteosarcoma accounts for approximately 56% of new bone tumors, making it the most primary malignant bone tumor in children and adolescents. The lungs are the most common site of metastases and once osteosarcoma spreads to the lungs, it is very difficult to treat. In order to improve the outcome of this disease, the biology of osteosarcoma needs to be better understood. There are numerous investigators around the world who have made seminal discoveries about the important molecular pathways and genetic alterations that contribute to the development and metastases of osteosarcoma. Other investigators have proposed novel therapeutic strategies including some based on the molecular and genetic phenotype of the disease. This volume will provide a comprehensive review of these new discoveries in one singular text, which will help move the field forward."
  • Hereditary angioedema in 2011 / Marco Cicardi -- Hereditary angioedema : diagnosis and pathogenic mechanisms / Allen P. Kaplan -- Current options for the acute treatment and prophylaxis of hereditary angioedema / Laraib Tabba & Timothy J. Craig -- Novel C1 inhibitors for hereditary angioedema / Henriette Farkas & Lilian Varga -- New drug targets and future direction : ecallantide / Jonathan A. Bernstein -- New drug targets and future direction : icatibant / Konrad Bork -- Index.
  • This book addresses the impacts of current and future reproductive technologies on our world food production and provides a significant contribution to the importance of research in the area of reproductive physiology that has never been compiled before. It would provide a unique opportunity to separate the impacts of how reproductive technologies have affected different species and their contributions to food production. Lastly, no publication has been compiled that demonstrates the relationship between developments in reproductive management tools and food production that may be used a reference for scientists in addressing future research areas. During the past 50 years assisted reproductive technologies have been developed and refined to increase the number and quality of offspring from genetically superior farm animal livestock species. Artificial insemination (AI), estrous synchronization and fixed-time AI, semen and embryo cryopreservation, multiple ovulation and embryo transfer (MOET), in vitro fertilization, sex determination of sperm or embryos, and nuclear transfer are technologies that are used to enhance the production efficiency of livestock species.
  • "Six decades after the serendipitous discovery of chlorpromazine as an antipsychotic and four decades after the launch of clozapine, the first atypical or second generation antipsychotic, psychopharmacology has arrived at an important crossroad. It is clear that pharmacological research and pharmaceutical development must now focus on complementary or even alternative mechanisms of action to address unmet medical needs, i.e. poorly treated domains of schizophrenia, improved acceptance by patients, better adherence to medication, safety in psychoses in demented patients, and avoiding cardiac and metabolic adverse effects. The first completely novel mechanisms evolving from our insights into the pathophysiology of psychotic disorders, especially the role of glutamatergic mechanisms in schizophrenia, are now under development, and further principles are on the horizon. This situation, in many respects similar to that when the initial second-generation antipsychotics became available, can be rewarding for all. Preclinical and clinical researchers now have the opportunity to confirm their hypotheses and the pharmaceutical industry may be able to develop really novel classes of therapeutics...Our intention was to capture both the accumulated preclinical and clinical knowledge about current antipsychotics as well as prospects for new and potentially more specific antischizophrenia principles. These efforts should be based on the pathophysiology of the diseases and the affected neurotransmitter systems. Since preclinical research on antipsychotic compounds is only reliable when intimately linked through translational aspects to clinical results, we decided to include clinical science as well. It turned out that that this endeavor could not be covered by a single volume. We [prepared] two volumes: Current Antipsychotics and Novel Antischizophrenia Treatments. These topics cannot really be separated from one another and should be seen as a composite entity despite the somewhat arbitrary separation of contributions into two volumes. The continuing challenges of developing improved and safer antipsychotic medications remain of concern and are discussed in the first volume. The new opportunities for the field to develop and license adjunctive treatments for the negative symptoms and cognitive deficits that are treated inadequately by existing compounds have been incentivized recently and provide the focus for the second volume."--Publisher's description.
  • Current approaches to allergic rhinitis / Cristoforo Incorvaia -- Allergic rhinitis : symptoms / Nerin N. Bahceciler & Nilufer Galip -- Allergic rhinitis : causes and pathogenesis / Giovanni Passalacqua -- Diagnostic tests in allergic rhinitis / Cristoforo Incorvaia & Franco Frati -- Nasal steroids in allergic rhinitis / Davide Caimmi, Silvia Caimmi, Roberto Raschetti, Ilaria Brambilla & Gian Luigi Marseglia -- Other treatments / Takeshi Nabe -- Index.
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  • 2010 MD Consult
  • Current clinical neurology v. 44-, 2005-13 ; 2013-
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  • Diagnosis of uveal melanoma -- Treatment selection for uveal melanoma -- Ruthenium-106 brachytherapy -- Treatment of uveal melanoma by accelerated proton beam -- Stereotactic photon beam irradiation of uveal melanoma -- Local resection of uveal melanoma -- Biopsies in uveal melanoma -- Analysis of intraocular biopsies -- Anti-angiogenic therapy in uveal melanoma -- Immunotherapy of uveal melanoma -- Genetic determinants of uveal melanoma -- Therapeutic options in metastatic uveal melanoma.
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  • Current diagnosis & treatment emergency medicine 7th ed. (2011)
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    Fulltext AccessMedicine, latest ed. only.
  • Current diagnosis & treatment in cardiology 2009 (3rd ed.)-2014 (4th ed.)
    2014 (4th ed.) AccessMedicine
  • Current diagnosis & treatment in orthopedics 2014 (5th ed.).
  • Includes more than 400 clinical photographs and line drawings and a comprehensive radiology chapter with more than 150 images.--excerpted from p. 4 of cover.
  • Screening guidelines for sexually transmitted diseases, including HIV infection / Jeffrey D. Klausner -- I. Syndromes -- Vaginal discharge / Jane Schwebke -- Urethral discharge / Jonathan M. Zenilman -- Genital ulcer disease / Daniel E. Cohan and Kenneth Mayer -- Lower abdominal pain in women / Mark H. Yudin and Harold C. Wiesenfeld -- Epididymitis & the acute scrotum syndrome / William M. Geisler and John N. Krieger -- Persistent & recurrent urethtitis / Philip M. Grant and Thomas M. Hooton -- Pelvic inflammatory disease / Craig R. Cohen -- Proctitis & proctocolitis / Anne M. Rompalo -- Cervicitis / Jeanne M. Marrazzo -- Bacterial vaginosis / Jane R. Schwebke -- II. Infections -- Chancroid / Stephanie N. Taylor and David H. Martin -- Genital chlamydial infections / William M. Eisler and Walter E. Stamm -- Genital herpes / Peter Leone -- External genital warts / Peter V. Chin-Hong and Joel M. Palefsky -- Gonorrhea / Heidi Swygard, Arlene C. Sena, Peter Leone, and Myron S. Cohen -- Lymphogranuloma venereum / Christopher S. Hall -- Trichomoniasis / Jane R. Schwebke -- Syphilis / Michael Augenbraun -- Neurosyphilis / Roger P. Simon -- III. Special topics -- Sexually transmitted diseases in HIV-infected persons / Lisa A. Mills and Thomas C. Quinn -- Sexually transmitted diseases in pregnancy / Natali Aziz and Craig R. Cohen -- Sexually transmitted diseases in adolescents / Renata Arrington-Sanders, Jeri Dyson, and Jonathan Ellen -- Sexually transmitted diseases in men who have sex with men / William Wong -- Sexually transmitted diseases in women who have sex with women / Jeanne M. Marrazzo -- Principles of serologic testing or syphilis / Edward W. Hook III -- Principles of risk reduction counseling / Cornelis A. Rietmeijer -- Partner notification & management / Thomas A. Peterman and Richard H. Kahn -- Management of abnormal pap smears / Michael E. Hagensee -- Commonly encountered genital dermatoses / Laura Hinkle Bachmann -- The sexual history / Jeffrey D. Klausner.
  • 21st ed., 2012 AccessMedicine
  • Clinical decision making in psychiatry / Barry Nurcombe -- Psychiatric epidemiology / Dan G. Blazer -- Psychiatric genetics / John I. Nurnberger, Jr. & Wade Berrettini -- The psychiatric interview / Barry Nurcombe & Michael H. Ebert -- Diagnostic encounter for children and adolescents / Barry Nurcombe -- Psychological and neuropsychological assessment / James S. Walker, Howard B. Roback, & Larry Welch -- Diagnostic evaluation for children and adolescents / Barry Nurcombe & Michael G. Tramontana -- Developmental psychology / Kenneth A. Dodge -- Psychopharmacologic interventions / Richard C. Shelton -- Behavioral and cognitive-behavioral interventions / Travis Thompson & Steven D. Hollon -- Psychodynamic and social interventions / James I. Nash & James W. Lomax -- Diagnostic formulation, treatment planning, and modes of treatment in children and adolescents / Barry Nurcombe -- Preventive psychiatry / Barry Nurcombe -- Delirium, dementia, and amnestic syndromes / Joseph A. Kwentus & Howard Kirshner -- Substance-related disorders / Richard C. Shelton -- Schizophrenia / Herbert Y. Meltzer ... [et al.] -- Other psychotic disorders / Richard C. Shelton -- Mood disorders / Peter T. Loosen & Richard C. Shelton -- Anxiety disorders / Richard C. Shelton -- Posttraumatic stress disorder and acute stress disorder / Douglas C. Johnson, John H. Krystal, & Steven M. Southwick -- Obsessive-compulsive disorder / William A. Hewlett -- Somatoform disorders / Charles V. Ford -- Factitious disorders and malingering / Charles V. Ford -- Dissociative disorders / Barry Nurcombe -- Sexual dysfunction and paraphilias / Richard Balon & R. Taylor Segraves -- Eating disorders / Harry E. Gwirtsman, James E. Mitchell, & Michael H. Ebert -- Sleep disorders / Camellia P. Clark, Polly J. Moore, & J. Christian Gillin -- Impulse-control disorders / John W. Thompson, Jr. & Daniel K. Winstead -- Adjustment disorders / Ronald M. Salomon & Lucy Salomon -- Personality disorders / David Janowsky -- Intellectual disability / Ludwik S. Szymanski, Sandra L. Friedman, & Elizabeth L. Leonard -- Learning disorders / Michael G. Tramontana -- Motor skills disorder and communication disorders / Michael G. Tramontana & Barry Nurcombe -- Autism and pervasive developmental disorders / Fred R. Volkmar -- Attention-deficit/hyperactivity disorder / Thomas Spencer -- Oppositional defiant disorder and conduct disorder / Barry Nurcombe -- Substance-related disorders in adolescents / Yifrah Kaminer & Deborah R. Simkin -- Depressive disorders in children and adolescents / David A. Brent & Lisa Pan -- Pediatric bipolar disorder / David A. Brent & Raymond J. Pan -- Suicidal behavior in children and adolescents / Robert A. King -- Anxiety disorders in children and adolescents / Barry Nurcombe -- Child maltreatment / William Bernet -- Posttraumatic stress disorder in children and adolescents following a single-event trauma / Brett McDermott -- Tourette disorder and obsessive-compulsive disorder in children and adolescents / Michael H. Bloch & James F. Leckman -- Developmental disorders of attachment, feeding, elimination, and sleeping / Barry Nurcombe -- Gender identity disorder / William Bernet -- Psychological reactions to acute and chronic systemic illness in pediatric patients / Barry Nurcombe -- Emergency psychiatry / Michael J. Sernyak, Jr. & Robert M. Rohrbaugh -- Consultation-liaison psychiatry / Catherine Chiles & Thomas N. Wise -- Forensic psychiatry / William Bernet.
  • "The book is a guide to the diagnosis and management of the complete range of rheumatologic problems encountered in clinical medicine, from common musculoskeletal complaints to complex, multiorgan system inflammatory diseases. Practical chapters on the evaluation of common musculoskeletal symptoms are accompanied by concise, authoritative reviews of multiorgan system disorders, supplemented by unique chapters on clinical topics of special interest"--Preface.
  • Current diagnosis & treatment, surgery 2015 (14th ed.)
    13th ed., 2006 AccessMedicine
    14th ed., 2015 AccessSurgery
    13th ed., 2006 AccessSurgery
  • ch. 1. Fluid & electrolyte disorders -- ch. 2. Acute renal failure -- ch. 3. Chronic renal failure -- ch. 4. Glomerular disorders -- ch. 5. Tubulointerstitial diseases -- ch. 6. Hypertension -- ch. 7. Cystic and genetic diseases of the kidney -- ch. 8. Renal replacement therapy -- ch. 9. Kidney disease in special populations -- ch. 10. Special topics in nephrology.
  • Principles of geriatric care -- Transforming the care of older adults: knowledge, skills, & system change -- Consideration of function & functional decline -- Goals of care & consideration of prognosis -- The social context of older adults -- The interprofessional team -- Geriatric assessment -- Atypical presentations of illness in older adults -- Prevention & health promotion -- Principles of prescribing for older adults -- Addressing multimorbidity in older adults -- Geriatrics & palliative care -- Ethics & informed decision making -- Care settings -- Transitions and continuity of care -- Ambulatory care & the patient-centered medical home -- Providing quality care to older adults in the emergency department -- Hospital care -- Perioperative care in older surgical patients -- Long-term care, nursing home, & rehabilitation -- Home-based care -- The aging traveler -- Common conditions in geriatrics -- Delirium -- Cognitive impairment & dementia -- Cerebrovascular disease -- Parkinson disease & essential tremor -- Falls & mobility disorders -- Osteoarthritis -- Osteoporosis & hip fractures -- Coronary disease -- Heart failure & heart rhythm disorders -- Hypertension -- Valvular disease -- Peripheral arterial disease & venous thromboembolism -- Chronic venous insufficiency & lymphedema -- Chronic obstructive pulmonary disease -- Gastrointestinal & abdominal complaints -- Constipation -- Fluid & electrolyte abnormalities -- Chronic kidney disease -- Urinary incontinence -- Benign prostatic hyperplasia & prostate cancer -- Thyroid, parathyroid, & adrenal gland disorders -- Diabetes -- Anemia -- Common cancers -- Depression & other mental health issues -- Sexual health & dysfunction -- Common infections -- Pressure ulcers -- Common skin disorders -- Sleep disorders -- Oral diseases & disorders -- Common clinical scenarios in geriatrics -- Evaluating confusion in older adults -- Addressing polypharmacy & improving medication adherence in older adults -- Managing persistent pain in older adults -- Considering anticoagulation in older adults -- Assessing antiaging therapies for older adults -- Considering complementary & alternative medicines for older adults -- Managing misuse of alcohol & psychoactive prescription medications in older adults -- Assessing older adults for syncope following a fall -- Treating headaches in older adults -- Managing vision impairment in older adults -- Managing hearing impairment in older adults -- Addressing chest pain in older adults -- Addressing dyspnea in older adults -- Managing joint pain in older adults -- Managing back pain in older adults -- Determining the appropriate use of exercise for older adults -- Defining adequate nutrition for older adults -- Helping older adults with low health literacy -- Understanding the effects of homelessness and housing instability on older adults -- Understanding the effects of criminal justice involvement on older adults -- Detecting, assessing, & responding to elder mistreatment -- Meeting the unique needs of LGBT older adults -- Broadening clinical practice -- Applying evidence-based medicine to older patients -- International perspectives in geriatric care -- Public policy intersecting with an aging society.
  • Clinical trials : planning and analysis / Farewell, V.T., Cook, R.J. -- The evidence base for growth hormone effectiveness in children / Kelnar, C.J.H. -- Safety of recombinant human growth hormone / Carel, J.-C., Butler, G. -- Diagnosis of growth hormone deficiency / Webb, E.A., Dattani, M.T. -- Biological determinants of responsiveness to growth hormone : pharmacogenomics and personalized medicine / Mullis, P.-E. -- Clinical considerations in using growth hormone therapy in growth hormone deficiency / Ranke, M.B. -- Current indications for growth hormone therapy for children and adolescents / Richmond, E., Rogol, A.D. -- GH use in the transition of adolescence to adulthood / Mauras, N.
  • Current Laboratory Methods in Neuroscience Research is a research manual for both students and seasoned researchers. It focuses on commonly-used techniques employed in neuroscience research, presented in a simple, step-by-step manner for laboratory use. The manual also offers a blueprint for bench-to-bedside research designed to facilitate multidisciplinary neuroscience pursuits. Sections include coverage of neurohistological techniques, in vitro preparations, leukocyte isolation and application in neuroscience, standard laboratory nucleic acid and protein detections, nanomedicine, bioimaging, neuroelectrophysiology, immunohistochemistry and autoradiography, analysis of gene expression, and animal models.
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  • Current medical diagnosis & treatment Latest edition, 2016 (55th ed.)
    54th ed., 2015 AccessMedicine
    53rd ed., 2014 AccessMedicine
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  • Current practice guidelines in primary care Latest edition, 2015.
    2014 ed. AccessMedicine
    2013 ed. AccessMedicine
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  • Current procedures. Surgery 2010
    1. Thyroidectomy and Neck Dissection -- 2. Parathyroidectomy -- 3. Adrenalectomy -- 4. Surgery of the Endocrine Pancreas -- 5. Transhiatal Esophagectomy -- 6. Operative Management of Gastric Lesions -- 7. Surgery of the Hiatus -- 8. Emergency Operations for Peptic Ulcer Disease -- 9. Surgical Therapies for Morbid Obesity -- 10. Enteral Access -- 11. Laparoscopic Cholecystectomy -- 12. Management of Complex Biliary Stone Disease -- 13. Management of Bile Duct Injuries and Biliary Strictures -- 14. Hepatectomy -- 15. Pancreaticoduodenectomy -- 16. Distal Pancreatectomy -- 17. Operative Management of Chronic Pancreatitis -- 18. Splenectomy -- 19. Small Bowel Resection -- 20. Appendectomy -- 21. Loop Colostomy, End Ileostomy, and Loop Ileostomy -- 22. Operative Management of Inflammatory Bowel Disease -- 23. Colectomy -- 24. Operative Management of Rectal Tumors -- 25. Operative Management of Rectal Prolapse -- 26. Benign Anorectal Procedures -- 27. Operative Management of Breast Cancer -- 28. Operative Management of Melanoma -- 29. Operative Management of Soft Tissue Sarcoma -- 30. Renal Transplantation -- 31. Pancreas Transplantation -- 32. Liver Transplantation -- 33. Vascular Access for Dialysis -- 34. Management of Infrarenal Abdominal Aortic Aneurysm -- 35. Carotid Endarterectomy -- 36. Operative Management of Aortoiliac Occlusive Disease -- 37. Surgical Revascularization of Infrainguinal Arterial Occlusive Disease -- 38. Management of Lower Extremity Venous Insufficiency -- 39. Below- and Above-the-Knee Amputation -- 40. Inguinal Hernia Repair -- 41. Ventral Hernia Repair -- 42. Wound Closure Techniques -- 43. Central Venous Access -- 44. Tube Thoracostomy -- 45. Tracheostomy and Emergency Cricothyroidotomy -- 46. Operative Management of Pyloric Stenosis: Pyloromyotomy -- 47. Pediatric Vascular Access -- 48. Pediatric Inguinal Hernia.
  • Volume/weight measurement -- Concentration measurement -- Reagent preparation -- Cell culture techniques -- Sample preparation -- Chromatography -- Electrophoresis -- Blotting -- Microscopy -- Enzymatic reactions.
  • ch. 1. Using biological databases -- ch. 2. Recognizing functional domains -- ch. 3. Finding similarities and inferring homologies -- ch. 4. Finding genes -- ch. 5. Modeling structure from sequence -- ch. 6. Inferring evolutionary relationships -- ch. 7. Analyzing expression patterns -- ch. 8. Analyzing molecular interactions -- ch. 9. Building biological databases -- ch. 10. Comparing large sequence sets -- ch. 11. Assembling sequences -- ch. 12. Analyzing RNA sequences and structures -- ch. 13. Using proteomics techniques -- ch. 14. Cheminformatics -- Appendix 1. User fundamentals -- Appendix 2. Glossary of bioinformatics terms -- Appendix 3. Fundamentals of bioinformatics.
  • ch. 1. Cell Culture -- ch. 2. Preparation and Isolation of Cells -- ch. 3. Subcellular Fractionation and Isolation of Organelles -- ch. 4. Microscopy -- ch. 5. Characterization of Cellular Proteins -- ch. 6. Electrophoresis and Immunoblotting -- ch. 7. Protein Labeling and Immunoprecipitation -- ch. 8. Cell Cycle Analysis -- ch. 9. Cell Adhesion -- ch. 10. Extracellular Matrix -- ch. 11. In Vitro Reconstitution -- ch. 12. Cell Motility -- ch. 13. Organelle Motility -- ch. 14. Signal Transduction: Protein Phosphorylation -- ch. 15. Protein Trafficking -- ch. 16. Antibodies as Cell Biological Tools -- ch. 17. Macromolecular Interactions in Cells -- ch. 18. Cellular Aging and Death -- ch. 19. Whole Organism and Tissue Analysis -- ch. 20. Expression and Introduction of Macromolecules into Cells -- ch. 21. Fluorescent Protein Technology -- ch. 22. Cell Biology of Chromosomes and Nuclei -- ch. 23. Stem Cells -- ch. 24. Lipids -- ch. 25. Nanotechnology -- ch. 26. Viruses -- ch. 27. RNA-Based Methods in Cell Biology -- Appendix 1. Useful Information and Data -- Appendix 2. Laboratory Stock Solutions and Equipment -- Appendix 3. Commonly Used Techniques -- Appendix. Suppliers.
  • Current Protocols in Chemical Biology provides validated protocols and overviews about specialized chemical techniques and tools for studies of biology and drug design. These tools include small-molecule design, synthesis, derivatization, handling, and detection as well as advances in laboratory automation, robotics, and medicinal chemistry as applied to high-throughput screening (HTS). Methods for modification of proteins, nucleic acids, carbohydrates and lipids for their use as tools in the study of particular biological systems are also included
  • Consists of a core publication dated Apr. 1997, and updated by supplements 1 (July 1997)-<57 (July 2010)>. Content is peer-reviewed protocols for flow and image cytometry updated quarterly.
  • ch. 1. Genetic Mapping -- ch. 2. Genotyping -- ch. 3. Somatic Cell Hybrids -- ch. 4. Cytogenetics -- ch. 5. Strategies for Large-Insert Cloning and Analysis -- ch. 6. Identifying Candidate Genes in Genomic DNA -- ch. 7. Searching Candidate Genes for Mutations -- ch. 8. Clinical Cytogenetics -- ch. 9. Clinical Molecular Genetics -- ch. 10. Cancer Genetics -- ch. 11. Transcriptional Profiling -- ch. 12. Vectors for Gene Therapy -- ch. 13. Delivery Systems for Gene Therapy -- ch. 14. Forensic Genetics -- ch. 15. Model Systems for the Analysis of Human Disease -- ch. 16. Automation and Robotics in Genetic Analysis -- ch. 17. Biochemical Genetics --ch. 18. High-Throughput Sequencing -- ch. 19. Mitochondrial Genetics -- ch. 20. Epigenetics -- Appendix 1. Abbreviations and Useful Data -- Appendix 2. Laboratory Guidelines, Equipment, and Stock Solutions -- Appendix 3. Commonly Used Techniques -- Appendix 4. Chromosome Karyotyping and Idiograms -- Appendix 5. Genetic Linkage Reference Maps: Access to Internet-Based Resources -- Appendix 6. Human-Mouse Comparative Maps -- Appendix. Suppliers.
  • ch. 1. Care and Handling of Laboratory Animals -- ch. 2. Induction of Immune Responses -- ch. 3. In Vitro Assays for Mouse Lymphocyte Function -- ch. 4. In Vivo Assays for Lymphocyte Function -- ch. 5. Immunofluorescence and Cell Sorting -- ch. 6. Cytokines and Their Cellular Receptors -- ch. 7. Immunologic Studies in Humans -- ch. 8. Isolation and Analysis of Proteins -- ch. 9. Peptides -- ch. 10. Molecular Biology -- ch. 11. Biochemistry of Cell Activation -- ch. 12. Detection and Analysis of HIV -- ch. 13. Complement -- ch. 14. Innate Immunity -- ch. 15. Animal Models for Autoimmune and Inflammatory Disease -- ch. 16. Antigen Processing and Presentation -- ch. 17. Engineering Immune Molecules and Receptors -- ch. 18. Ligand-Receptor Interactions in the Immune System -- ch. 19. Animal Models for Infectious Diseases -- ch. 20. Animal Models for Tumor Immunology -- ch. 21. Microscopy -- ch. 22. Isolation and Differentiation of Stem and Progenitor Cells -- Appendix 1. Abbreviations and Useful Data -- Appendix 2. Commonly Used Reagents and Equipment -- Appendix 3. Commonly Used Immunological Techniques -- Appendix 4. The CD System of Leukocyte Surface Molecules -- Appendix 5. Suppliers.
  • Emerging technologies -- Microscopy -- Alpha proteobacteria -- Beta proteobacteria -- Enteric gamma proteobacteria -- Nonenteric gamma proteobacteria -- Delta proteobacteria -- Epsilon proteobacteria -- Firmicutes (low G+C gram positive) -- Actinobacteria (high G+C gram positive) -- Chlamydiae -- Spirochetes -- Other eubacteria -- Animal DNA viruses -- Animal RNA viruses -- Plant RNA viruses.
  • ch. 1. Escherichia coli, Plasmids, and Bacteriophages -- ch. 2. Preparation and Analysis of DNA -- ch. 3. Enzymatic Manipulation of DNA and RNA -- ch. 4. Preparation and Analysis of RNA -- ch. 5. Construction of Recombinant DNA Libraries -- ch. 6. Screening of Recombinant DNA Libraries -- ch. 7. DNA Sequencing -- ch. 8. Mutagenesis of Cloned DNA -- ch. 9. Introduction of DNA into Mammalian Cells -- ch. 10. Analysis of Proteins -- ch. 11. Immunology -- ch. 12. DNA-Protein Interactions -- ch. 13. Yeast -- ch. 14. In Situ Hybridization and Immunohistochemistry -- ch. 15. The Polymerase Chain Reaction -- ch. 16. Protein Expression -- ch. 17. Preparation and Analysis of Glycoconjugates -- ch. 18. Analysis of Protein Phosphorylation -- ch. 19. Informatics for Molecular Biologists -- ch. 20. Analysis of Protein Interactions -- ch. 21. Chromatin Assembly and Analysis -- ch. 22. Nucleic Acid Arrays -- ch. 23. Manipulating the Mouse Genome -- ch. 24. Generation and Use of Combinatorial Libraries -- ch. 25. Discovery and Analysis of Differentially Expressed Genes in Single Cells and Cell Populations -- ch. 26. Gene Silencing -- ch. 27. RNA-Protein Interactions -- ch. 28. Mammalian Cell Culture -- ch. 29. Mouse Phenotyping -- ch. 30. Metabolomics -- Appendix 1. Standard Measurements, Data, and Abbreviations -- Appendix 2. Commonly Used Reagents and Equipment -- Appendix 3. Commonly Used Techniques in Biochemistry and Molecular Biology -- Appendix 4. Suppliers -- Appendix 5. Vectors -- Appendix 6. Pathway Modulators and Inhibitors.
  • ch. 1. Neuroanatomical Methods -- ch. 2. Imaging -- ch. 3. Cellular and Developmental Neuroscience -- ch. 4. Gene Cloning, Expression, and Mutagenesis -- ch. 5. Molecular Neuroscience -- ch. 6. Neurophysiology -- ch. 7. Neurochemistry/Neuropharmacology -- ch. 8. Behavioral Neuroscience -- ch. 9. Preclinical Models of Neurologic and Psychiatric Disorders -- ch. 10. Human Neuroscience -- Appendix 1. Molecular Biology Techniques -- Appendix 2. Stock Solutions, Equipment, and Laboratory Guidelines -- Appendix 3. Commonly Used Techniques -- Appendix 4. Animal Techniques -- Appendix 5. Databases -- Suppliers.
  • Includes methods for isolating, maintaining, and differentiating embryonic and adult stem cells.
  • Acupuncture Modulation of Neural Transmitters/Modulators / Jianfeng Liang and Ying Xia -- Cellular Mechanisms in Acupuncture Points and Affected Sites / Wolfgang Schwarz and Quanbao Gu -- Function of Collagen and Mast Cells in Acupuncture Points / Guanghong Ding, Di Zhang, Meng Huang, Lina Wang and Wei Yao -- Functional Magnetic Resonance Imaging in Basic Acupuncture Research / Florian Beissner -- Chemical and Physical Characteristics of Moxibustion / Ling Zhao and Xueyong Shen -- Acupuncture Treatment of Epilepsy / Dongman Chao and Ying Xia -- Acupuncture Treatment for Parkinson's Disease / Tetsuya Asakawa and Ying Xia -- Can Acupuncture Treat Alzheimer's Disease and Other Neurodegenerative Disorders? / Tetsuya Asakawa and Ying Xia -- Acupuncture Therapy for Vascular Cognitive Impairment / Guoqiang Wen, Tao Liu, Shixiong Huang, Qiao Fu and Tao Chen, et al. -- Acupuncture and Moxibustion for Antiaging / Huangan Wu -- Development and Progression of Auricular Acupuncture as a Treatment for Anxiety and Pain / Shu-Ming Wang -- Abdominal Acupuncture for Nerve Root Cervical Spondylosis / Xiangrui Wang and Yongjun Zheng -- Electro-acupuncture Regulation of Central Monoamine Neurotransmitters in Ischaemia-Reperfusion / Mingshu Xu, Linbao Ge and Dan Zhao -- Protective Effect of Acupuncture on Myocardium / Xianrui Wang and Yongjun Zheng -- Acupuncture's Role in Cardiovascular Homeostasis / Peng Li, Stephanie C. Tjen-A-Looi and John C. Longhurst -- Acupuncture in Polycystic Ovary Syndrome: Potential and Challenge / Yi Feng, Elisabet Stener-Victorin and Boying Chen -- Auricular Acupuncture for Pain and Inflammation / Shi Ping Zhang, Wai Yeung Chung and Yi Jie Zhan -- Glial-Neuronal Interactions in Electroacupuncture Analgesia / Hong Cao, Zhi-Qi Zhao, Gen-Cheng Wu and Yu-Qiu Zhang -- Meridian-Viscera Correlationship / Yiping Zhou, Keming Wang, Ling Hu, Meiqi Zhou and Zijian Wu, et al. -- Theory and Methodology of Evidence-Based Medicine in Acupuncture Research / Fanrong Liang, Tingting Ma, Wenjing Huang, Xi Wu and Ying Li, et al. -- Chinese Medicine as a Model of System Biology: Diagnosis as the Foundation of Acupoint Selection / Henry Johannes Greten -- Modernization of Acupuncture Using High-Tech Methods: Teleacupuncture Bridges Science and Practice / Gerhard Litscher -- Future Research in Acupuncture: Better Design and Analysis for Novel and Valid Findings / Tetsuya Asakawa and Ying Xia.
  • Development of a conditional mouse model for head and neck squamous cell carcinoma / Bindels, E.M.J., van de Brekel, M.W.M. -- Hypofolatemia as a risk factor for head and neck cancer / Almadori, G. ... [et al.] -- Reduced DNA repair capacity in laryngeal cancer subjects: a comparison of phenotypic and genotypic results / Gajacka, M. ... [et al.] -- Intratumoral genomic heterogeneity in advanced head and neck cancer detected by comparative genomic hybridization / Götte, K. ... [et al.] -- Function and importance of p63 in normal oral mucosa and squamous cell carcinoma of the head and neck / Thurfjell, N. ... [et al.] -- p53, p63 and p73 expression in squamous cell carcinomas of the head and neck and their response to cisplatin exposure / Balz, V. ... [et al.] -- Expression of p16 protein is associated with human papillomavirus status in tonsillar carcinomas and has implications on survival / Wittekindt, C. ... [et al.] -- EGFR-antibody-supplemented TPF chemotherapy: preclinical investigations to a novel approach for head and neck cancer induction treatment / Knecht, R. ... [et al.] -- Nuclear factor kappa B as a common target and activator of oncogenes in head and neck squamous cell carcinoma / Chang, A.A., Van Waes, C. -- Antiangiogenic therapy of head and neck squamous cell carcinoma by vascular endothelial growth factor antisense therapy / Riedel, F. ... [et al.] -- Expression pattern of chemokine receptors 6 and 7 in squamous cell carcinoma of the head and neck identifies a novel metastatic phenotype / Wang, J. ... [et al.] -- p53-based immunotherapy of cancer / De Leo, A.B. -- p53 as an immunotherapeutic target in head and neck cancer: approaches to reversing unresponsiveness of T lymphocytes and preventing tumor escape / Hoffmann, T.K. ... [et al.] -- Imbalance in absolute counts of T lymphocyte subsets in patients with head and neck cancer and its relation to disease / Kuss, I. ... [et al.] -- Antitumor immunization of head and neck squamous cell carcinoma patients with a virus-modified autologous tumor cell vaccine / Herold-Mende, C. ... [et al.] -- Prognostic factors: confusion caused by bad quality of design, analysis and reporting of many studies / Sauerbrei, W.
  • Advances in pharmacotherapy and psychosocial interventions continue to improve the success of managing schizophrenia. Early detection and intervention in people with, or at risk for, psychosis give patients and their families hope for a better course of illness and an improved outcome. The interdisciplinary approach, combining pharmacotherapy and psychosocial interventions, markedly increases the chance of long-lasting remission and recovery. However, a cure for schizophrenia has yet to be found. Research, particularly in the past decade, has revealed some of the biological and genetic facets of the origins of schizophrenia, and this has contributed to the better quality of treatment. This book aims to provide a short but detailed overview of current standards of care in schizophrenia. It takes into consideration several treatment recommendations proposed in published guidelines for schizophrenia, including the guidelines by the National Institute for Health and Clinical Excellence (2009), the American Psychiatric Association (2004), the Canadian Psychiatric Association (2005), and the Royal Australian and New Zealand College of Psychiatrists (2005). A major problem with guidelines such as these is the difficulties encountered in translating them into daily clinical practice. Therefore, the fundamental aim of this book is to present the guidelines as clearly as possible in the context of relevant clinical treatment issues. The book does this with the help of figures that provide the clinician with algorithms and summaries of the most important information required for the practical treatment and theoretical understanding of schizophrenia.
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  • 2012 ClinicalKey
    Written by expert surgeons and educators, Current Therapy in Oral and Maxillofacial Surgery covers the latest treatment strategies, surgical techniques, and potential complications in OMS. Emphasizing an evidence-based approach, it covers all 12 subspecialties of OMS, addressing topics from surgical principles to oral surgery, anesthesia, cranio-maxillofacial trauma surgery, head and neck surgery, maxillofacial reconstructive surgery, orthognathic surgery, pediatric craniofacial surgery including cleft lip and palate, temporomandibular joint disorders, facial plastic surgery including rhinoplasty and facelifts, obstructive sleep apnea, and oral and maxillofacial infections. At the end of each chapter, Pearls and Pitfalls summarize the authors' insight, recommendations, and experience on that topic. Editor Dr. Shahrokh Bagheri is a noted professor, researcher, and speaker on OMS, and he leads an expert author team including Dr. R. Bryan Bell and Dr. Husain Ali Khan to help you master and apply the latest advances in OMS. More than 1,200 full-color photos and 200 color line drawings illustrate concepts and provide visual guidance in clinical areas. Comprehensive sections and chapters represent essential topics, the newest advances, and controversial topics. Clinical coverage brings together the latest knowledge in OMS in a concise, easy-to-apply way. Resident-specific coverage describes the wide array of subspecialties and treatments available in the armamentarium of the modern OMS. A focus on complications ensures that you are knowledgeable in this important part of any therapy or surgical discipline. Expert contributors include the "best of the best," featuring leading, well-established, and respected surgeons and educators writing on their areas of specialty and providing current treatment strategies.
  • This titles addresses the evolving science of orthodontics as it relates to optimal patient therapy and care. Topics covered include diagnosis and treatment planning, the management of sagittal and vertical discrepancies, the management of adult and complex cases, and the application of biomedicine in orthodontic treatment.
  • Current therapy in pain 2009
    This unique resource focuses on the diagnosis and treatment of painful conditions, both acute and chronic, from a multi-disciplinary perspective. Joined by a team of nearly 200 international contributors representing a wide range of specialties, Dr. Smith presents the best management options within and across specialties. Succinct treatment and therapy guidelines enable you to quickly access clinically useful information, for both inpatient and outpatient pain management, while a 2-color format enhances readability and ease of use and highlights key concepts. And, as an Expert Consult title, it includes access to the complete contents online, fully searchable, plus links to Medline and PubMed abstracts, providing rapid, easy consultation from any computer! Includes access to the complete text online, fully searchable, plus links to Medline and PubMed abstracts, providing quick and convenient reference from anyplace with an Internet connection. Offers a cross-discipline approach to pain management for a comprehensive view of the best treatment options within and across specialties including internal medicine, gynecology, physical medicine and rehabilitation, orthopedics, and family medicine. Provides succinct treatment and therapy guidelines, enabling you to locate useful information quickly. Organizes guidance on acute and chronic therapies in a templated format, to facilitate consistent, quick-access consultation appropriate for inpatient or outpatient pain management. Features a 2-color format that enhances readability and ease of use and highlights key concepts.
  • Demanding surgical situations require expert advice from pioneers in the field as well as from those on the front lines of trauma care. Practical and evidence-based, Current Therapy of Trauma and Surgical Critical Care, 2nd Edition, draws on the experience of Drs. Juan A. Asensio and Donald D. Trunkey to offer a comprehensive, contemporary summary of the treatment and post-operative management of traumatic injuries. The concise format makes it ideally suited for everyday use, and new, full-color illustrations highlight the most important aspects of urgent surgical care, including ventilator management, damage control, noninvasive techniques, imaging, infection control, dealing with mass casualties, and treating injuries induced by chemical and biological agents.
  • 1. Cross-disciplinary research stirs new challenges into the study of the structure, function, and systems biology of complement / Dimitrios Mastellos and John D. Lambris -- 2. Liver regeneration: a link to inflammation through complement / Robert A. DeAngelis, Maciej M. Markeiwski, and John D. Lambris -- 3. The Role of third complement component (C3) in homing of hematopoietic stem/progenitor cells into bone marrow / Ryan Reca ... [et al.] -- 4. Complement system and the eye / Purushottam Jha ... [et al.] -- 5. To regeneration ... with complement / Panagiotis A. Tsonis, John D. Lambris, and Katia Del Rio-Tsonis -- 6. Self, non-self and danger: a complementary view / Jörg Köhl -- 7. gClqR/p33 serves as a molecular bridge between the complement and contact activation systems and is an important catalyst in inflammation / Berhane Ghebrehiwet ... [et al.] -- 8. Possible immunoprotective and angiogenesis-promoting roles for malignant cell-derived prostasomes: a new paradigm for prostatic cancer? / Kristina Nilsson Ekdahl ... [et al.] -- 9. Diversified components of the bony fish complement system: more genes for robuster innate defense? / Miki Nakao ... [et al.] -- 10. C5b-9 complement complex in autoimmune demyelination: dual role in neuroinflammation and neuroprotection / Horea Rus, Cornelia Cudrici, and Florin Niculescu -- 11. The Double-edged flower: roles of complement protein C1q in neurodegenerative diseases / Andrea J. Tenner and Maria I. Fonseca -- 12. The Role of the complement system in the pathogenesis of experimental autoimmune encephalomyelitis and multiple sclerosis / Nóra Terényi, József Prechl, and Anna Erdei -- 13. The Complement system: a potential target for stroke therapy / J. Mocco ... [et al.] -- 14. Observations on complement activity in the two-stage inflammatory/hemostatic response in the baboon and human models of E. coli sepsis and endotoxemia / Fletcher B. Taylor, Jr., Eric Hack, and Florea Lupu -- 15. Complement activation during sepsis in humans / Heike Schreiber ... [et al.] -- 16. Three distinct profiles of serum complement C4 proteins in pediatric systemic lupus erythematosus (SLE) patients: tight associations of complement C4 and C3 protein levels in SLE but not in healthy subjects / Yee-Ling Wu ... [et al.] -- 17. A Minimum CR2 binding domain of C3d enhances immunity following vaccination / Joseph F. Bower and Ted M. Ross -- 18. Structure and function of ficolins / Yuichi Endo, Yu Liu, and Teizo Fujita -- 19. Role of mannose-binding lectin (MBL2) genotyping in predicting the risk of recurrent otitis media (rOM) / Lieve Nuytinck ... [et al.] -- 20. Conformational complexity of complement component C3 / Bert J.C. Janssen and Piet Gros -- 21. Disease-associated sequence variations in factor H: a stuctural biology approach / Andrew P. Herbert ... [et al.] -- 22. Transdermal pharmacology of small molecule cyclic C5a antagonists / Lavinia M. Proctor ... [et al.] -- 23. Inactivation of complement by recombinant human C3 derivatives / Edzard Spillner, Johanna Kölln, and Reinhard Bredehorst -- 24. Complement analysis in clinic and research / Tom E. Mollnes and Michael Kirschfink -- 25. Cell-bound complement activation products (CB-CAPs) as a source of lupus biomarkers / Sarah J. Calano ... [et al.].
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  • Pentraxins in Humoral Innate Immunity / Antonio Inforzato, Barbara Bottazzi, Cecilia Garlanda, Sonia Valentino and Alberto Mantovani -- Galectins as Pattern Recognition Receptors: Structure, Function, and Evolution / Gerardo R. Vasta -- The Role of Innate Immunity in Trafficking of Hematopoietic Stem Cells - An Emerging Link Between Activation of Complement Cascade and Chemotactic Gradients of Bioactive Sphingolipids / Mariusz Z. Ratajczak, ChiHwa Kim, Wan Wu, Dong Myung Shin and Ewa Bryndza, et al. -- Interaction of the Microbiome with the Innate Immune Response in Chronic Wounds / Elizabeth A. Grice and Julia A. Segre -- Pathogenic Microbes and Community Service Through Manipulation of Innate Immunity / George Hajishengallis, Jennifer L. Krauss, Shuang Liang, Megan L. McIntosh and John D. Lambris -- A Conserved Host and Pathogen Recognition Site on Immunoglobulins: Structural and Functional Aspects / Bruce D. Wines, Halina M. Trist, William Farrugia, Chloe Ngo and John Trowsdale, et al. -- Advances in Understanding the Structure, Function, and Mechanism of the SCIN and Efb Families of Staphylococcal Immune Evasion Proteins / Brandon L. Garcia, Kasra X. Ramyar, Daniel Ricklin, John D. Lambris and Brian V. Geisbrecht -- Granzyme B: A New Crossroad of Complement and Apoptosis / Mario Perl, Stephanie Denk, Miriam Kalbitz and Markus Huber-Lang -- Role of C3, C5 and Anaphylatoxin Receptors in Acute Lung Injury and in Sepsis / Markus Bosmann and Peter A. Ward -- Complement Involvement in Neovascular Ocular Diseases / Ryoji Yanai, Aristomenis Thanos and Kip M. Connor -- Platelets, Complement, and Contact Activation: Partners in Inflammation and Thrombosis / Osama A. Hamad, Jennie Bäck, Per H. Nilsson, Bo Nilsson and Kristina N. Ekdahl -- Nuclear Factor-κB in Immunity and Inflammation: The Treg and Th17 Connection / Qingguo Ruan and Youhai H. Chen -- Function of Act1 in IL-17 Family Signaling and Autoimmunity / Ling Wu, Jarod Zepp and Xiaoxia Li -- Differential Effect of Inhibiting MD-2 and CD14 on LPS- Versus Whole E. coli Bacteria-Induced Cytokine Responses in Human Blood / D. Christiansen, O. L. Brekke, J. Stenvik, J. D. Lambris and T. Espevik, et al. -- Zebrafish: Model for the Study of Inflammation and the Innate Immune Response to Infectious Diseases / Beatriz Novoa and Antonio Figueras -- Monocyte-derived Inflammatory Dendritic Cells in the Granuloma During Mycobacterial Infection / Heidi A. Schreiber and Matyas Sandor -- NK/DC Crosstalk in Anti-viral Response / Emanuela Marcenaro, Simona Carlomagno, Silvia Pesce, Alessandro Moretta and Simona Sivori -- Innate-Adaptive Crosstalk: How Dendritic Cells Shape Immune Responses in the CNS / Benjamin D Clarkson, Erika Héninger, Melissa G Harris, JangEun Lee and Matyas Sandor, et al. -- Nutritional Immunity: Homology Modeling of Nramp Metal Import / Mathieu F. M. Cellier.
  • Current topics in neurotoxicity v. 1-, 2012-
    Consists of volumes that cover the latest developments in neurotoxicity studies including neurodegeneration, neuroprotection, and neuroregeneration. The series has a translational focus and addresses the causes of neurotoxicity associated with diseases such as Alzheimers, Parkinsons Disease, autism, HIV associated dementia etc.
  • Features of enteric infections in Asia -- Molecular epidemiology of vibrio cholerae and campylobacters isolated in Asian countries -- Diarrheal diseases and probiotics -- Dengue and chikungunya virus infection in Southeast Asia: active governmental intervention in Republic of Singapore -- Current global situation of tuberculosis, with a focus on Japan -- Tuberculosis among the poor -- The status and trends of HIV/AIDS epidemics in Asia and the Pacific -- Disease characteristics and treatment of 2009 H1N1 influenza -- Drug-resistant respiratory pathogens in Japan.
  • Introduction / Wayne R. Gombotz and Steven J. Shire -- Design of therapeutic MABS. CDR repair: a novel approach to antibody humanization / Mark S. Dennis -- Nanobodies, single-domain antigen-binding fragments of camelid heavy-chain antibodies / Gholamreza Hassanzadeh Ghassabeh, Serge Muyldermans, and Dirk Saerens -- Expression and production of MABS. GPEx® a flexible method for the rapid generation of stable, high expressing, antibody producing mammalian cells lines / Gregory T. Bleck -- Advancing our cell culture platform: incorporating lessons learned and new technologies / Carole Heath -- Recovery and purification. Addressing changes associated with technology transfer: a case study / Michele M. Myers ... [et al.] -- Concepts for disposables in biopharmaceutical manufacture / Joachim K. Walter and Uwe Gottschalk -- Formulation and delivery. Formulation and delivery issues for monoclonal antibody therapeutics / Ann L. Daugherty and Randall J. Mrsny -- Challenges in the development of high protein concentration formulations / Steven J. Shire, Zahra Shahrock, and Jun Liu -- Protein immobilization by crystallization and precipitation: an alternative to lyophilization / Karoline Bechtold-Peters -- Analytics and specification setting for MABS. Characterizing high affinity antigen/antibody complexes by kinetic and equilibrium based methods / Andrew W. Drake, David G. Myszka, and Scott L. Klakamp -- Analytical characterization of monoclonal antibodies: linking structure to function / Reed J. Harris ... [et al.] -- Analysis of irreversible aggregation, reversible self-association and fragmentation of monoclonal antibodies by analytical ultracentrifugation / James D. Andya, Jun Liu, and Steven J. Shires -- Biophysical signatures of monoconal antibodies / N. Harn ... [et al.] -- Pharmacokinetics and immunogenicity. Impact of Fc glycosylation on monoclonal antibody effector functions and degradation by proteases / T. Shantha Raju -- Immunogenicity assessment of antibody therapeutics / P. stas, Y. Gansemans, and I. Lasters -- Armed antibodies and new classes of antibodies. Production of monoclonal antibodies in E. coli / Dorothea E. Reilly and Daniel G. Yansura -- Recent advances in the use of antibody drug conjugates for cancer theapy / Peter D. Senter -- Antibody radiolabeling / Corinne Bensimon and Russell Redshaw.
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  • Epidemiology of Gliomas -- Glioma biology and molecular markers -- Surgery for Gliomas-- Radiation therapy of Glioblastoma -- Low-grade Glioma -- Treatment of anaplastic Glioma -- Current medical treatment of Glioblastoma -- Novel chemotherapeutic approaches in adult high-grade Gliomas -- Immunotherapy for malignant Gliomas -- Glioblastoma in the elderly -- Palliative and supprotive care for Glioma patients.
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  • Cushing's disease 2011
    Cushing's Disease: An Historical Perspective -- Molecular Biology of Cushing's Disease -- Pathology of Cushing's Disease -- The Diagnosis of Cushing's Syndrome -- Pseudo-Cushing's Syndrome -- Cyclic Cushing's Disease -- Differential Diagnosis of Cushing's Syndrome -- Radiologic Imaging Techniques in Cushing's Disease -- Surgical Treatment of Cushing's Disease -- Postoperative Management and Assessment of Cure -- Radiation Therapy in the Management of Cushing's Disease -- Medical Management of Cushing's Disease -- Recurrent Cushing's Disease -- Diagnosis and Treatment of Pediatric Cushing's Disease -- Silent Corticotroph Adenomas -- Cushing's Syndrome in Pregnancy -- Nelson's Syndrome: Corticotroph Tumor Progression After Bilateral Adrenalectomy in Cushing's Disease -- Psychosocial Aspects of Cushing's Disease.
  • Physiology and pathophysiology of the HPA axis -- Etiologies of Cushing's syndrome -- Pathogenesis of corticotropic tumors -- Pathogenesis of adrenocortical tumors -- Clinical features of Cushing's syndrome -- Laboratorial diagnosis of Cushing's syndrome: differential diagnosis with pseudo Cushing's conditions as obesity, alcoholism and depression -- Laboratorial diagnosis of Cushing's syndrome: differential diagnosis among the different causes of ACTH-dependent and ACTH-independent Cushing's syndrome -- Imaging for the differential diagnosis of Cushing's syndrome: MRI, CT, and isotopic scanning -- Inferior petrosal sampling for the differential diagnosis of ACTH-dependent Cushing's syndrome -- The surgical management of Cushing's disease -- Adrenal-directed treatment options for Cushing's disease -- Radiation therapy and stereotactic radiosurgery for Cushing's disease -- Medical management of Cushing's syndrome -- ACTH-dependent Cushing syndrome: clinical and diagnostic aspects, and treatment approaches for ectopic Cushing's syndrome -- Revisiting the Nelson's syndrome: corticotroph tumor progression after bilateral adrenalectomy in Cushing's disease -- ACTH-independent Cushing's syndrome: adrenocortical tumors -- ACTH-independent Cushing's syndrome: bilateral macronodular hyperplasia -- ACTH-independent Cushing's syndrome: primary pigmented nodular adrenal disease in the context of Carney's complex -- Glucocorticoid resistance -- Post-operative replacement and assessment of HPA axis recovery in Cushing's syndrome -- Special aspects of Cushing's syndrome: pregnancy -- Special aspects of Cushing's syndrome: childhood -- Special aspects of Cushing's syndrome: cyclic Cushing's syndrome.
  • Immunology of Cutaneous Drug Eruptions -- Principles of Diagnosis of Cutaneous Drug Eruptions -- Histopathology of Drug Reactions -- Principles of Treatment of Cutaneous Drug Eruptions -- Morbilliform Drug Eruptions -- Drug-Induced Urticaria -- Erythema Multiforme and Drug Reactions -- Drug-Induced Vasculitis -- Pigment Changes and Drug Reactions -- Drug-induced Photosensitivity -- Erythema Nodosum as a Drug Eruption -- Lichen Planus Drug Reactions -- Pityriasis Rosea-Like Drug Eruptions -- Psoriasiform Drug Eruptions and Drugs that Flare Psoriasis -- Acne and Drug Reactions -- Collagen Vascular Diseases and Cutaneous Drug Reactions -- Fixed Drug Eruptions -- Autoimmune Bullous Diseases and Drugs -- Lymphoma and Pseudolymphoma and Drug Reactions -- Drug-Induced Alopecia -- Drug Eruptions of the Scalp -- Drug Reactions in the Nail in Cutaneous Drug Eruptions -- Drug Eruptions and Generalized Exfoliative Erythroderma -- Stevens?Johnson Syndrome and Toxic Epidermal Necrolysis -- Drug-induced Delayed Multi-organ Hypersensitivity Syndrome -- Acute Generalized Exanthematous Pustulosis -- Cutaneous Drug Reactions to Anticoagulants -- Antiepileptic Medications and Cutaneous Drug Reactions -- Chemotherapy and Cutaneous Drug Reactions -- Tyrosine Kinase Medications and the Skin -- Medical Therapies and Their effects on Skin Cancer -- Cutaneous Reactions to BRAF Inhibitors -- Cutaneous Reactions to Corticosteroids -- Cutaneous Reactions to Retinoids -- Neutrophilic Dermatoses -- Granulomatous Drug Reactions -- Cutaneous Drug Reactions in Patients Infected with Human Immunodeficiency Virus -- Pediatric Drug Eruptions of the Skin.
  • "This textbook, containing a plethora of illustrations and pictures, will serve as an atlas and as a superb guide to the use of cutaneous flaps in head and neck reconstruction. Each chapter depicts, in a layered manner, the anatomy of a particular donor site from which flaps are derived and used in head and neck defects, providing systematic steps in understanding the topographical anatomy of the various tissue layers. The flaps derived from each donor site are presented in detail, with step-by-step instructions in flap design and harvesting techniques based in anatomy. The author uses numerous high-quality color illustrations drawn from his own practice in order to demonstrate the techniques. His combined expertise as a maxillofacial surgeon and an assistant professor of anatomy enables him to explain clearly the transition from basic science anatomy to applied anatomy and to document reconstructive surgical techniques in precise detail. This beautifully illustrated book, including many basic and advanced flap designs, will be an illuminating reference for all who treat defects in the head and neck area."--Publisher's website.
  • This volume explores the nexus of manifestations of hematopathology and dermatopathology and provides a novel compartmental(epidermal, dermal, subcutaneous) -based framework to approach a diagnosis that considers both pseudolymphomatous and lymphomatous patterns. Through photographs, tables, and text, the book illustrates the range of non-neoplastic hematologic disorders and their neoplastic counterparts in skin: reactive patterns of infectious etiology and immune responses that simulate cutaneous lymphomas. The epidemiology, pathobiology, clinical and immuno-histopathologic manifestations in skin as well as the approach to diagnosis, selection and algorithmic interpretation of tests, and prognosis are also described. Written by experts in the field, Cutaneous Hematopathology: Approach to the Diagnosis of Atypical Lymphoid-Hematopoietic Infiltrates in Skin is a comprehensive resource that is of great value to surgical pathologists, hematopathologists, dermatopathologists, residents and fellows, community dermatologists, oncologists and infectious disease practitioners.
  • v. 2 Unusual cases.
  • The skin is the most accessible organ of the body and also the most frequently injured organ in physical abuse of children. The interpretation of skin lesions, however, is not always simple. In recent years, many reports have been published on pediatric dermatological disorders and accidental injuries that were unjustly regarded as physical signs of child abuse. Knowledge of the differential diagnosis of unexplained skin findings is essential for accurate diagnosis and of vital importance given that errors in either direction (false positive or false negative) can have disastrous consequences.
  • Subcutaneous and deep mycoses -- Hyalohyphomycosis -- Superficial mycoses -- Algae -- Mycobacteria -- Viruses -- Rickettsiae -- Crusted scabies -- Protozoa -- Helminth -- Spirochete -- Gram-Positive bacteria -- Gram-negative bacteria -- Viral related malignancies -- Clues to the diagnosis of skin lesions in the immunocompromised host -- Differential diagnoses.
  • The Peripheral Nerve and Cutaneous Neural Tumors: Introduction, Definitions, and Classification -- Special Techniques for the Study of Cutaneous Neural Tumors -- Nonneoplastic and Hamartomatous Lesions of the Cutaneous Peripheral Nerve -- Benign Cutaneous Neoplasms with Peripheral Nerve Differentiation -- Malignant Cutaneous Neoplasms with Peripheral Nerve Differentiation -- Cutaneous Proliferations with Putative Neural Differentiation -- Cutaneous Neuroblastic and Ganglion Cell Proliferations -- Cutaneous Glial and Meningothelial Proliferations -- Appendix: Practical Approach to Neural Tumors? Flowcharts and Differential Diagnostic Table.
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    Vaccines have saved more lives than any other single medical advance. Yet today only four companies make vaccines, and there is a growing crisis in vaccine availability. Why has this happened? This remarkable book recounts for the first time a devastating episode in 1955 at Cutter Laboratories in Berkeley, California, that has led many pharmaceutical companies to abandon vaccine manufacture. Drawing on interviews with public health officials, pharmaceutical company executives, attorneys, Cutter employees, and victims of the vaccine, as well as on previously unavailable archives, Dr. Paul Offit offers a full account of the Cutter disaster. He describes the nation's relief when the polio vaccine was developed by Jonas Salk in 1955, the production of the vaccine at industrial facilities such as the one operated by Cutter, and the tragedy that occurred when 200,000 people were inadvertently injected with live virulent polio virus: 70,000 became ill, 200 were permanently paralyzed, and 10 died. Dr. Offit also explores how, as a consequence of the tragedy, one jury's verdict set in motion events that eventually suppressed the production of vaccines already licensed and deterred the development of new vaccines that hold the promise of preventing other fatal diseases.
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  • Cyanobacteria
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    Overview -- Occurance workgroup -- Causes, prevention, and mitigation workgroup -- Toxins workgroup -- Analytical methods workgroup -- Human health effects workgroup -- Ecosystem effects workgroup -- Risk assessment workgroup.
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  • Over the last two decades there has been a growing interest in cyclic nucleotide research in plants with an emphasis on the elucidation of the roles of cGMP and cAMP. In Cyclic Nucleotide Signaling in Plants: Methods and Protocols, expert researchers in the field detail many approaches to better understand the biological role of this important signaling system. Written in the highly successful Methods in Molecular Biology [trademark] series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Cyclic Nucleotide Signaling in Plants: Methods and Protocols seeks to aid scientist in further understanding signal transduction and the molecular mechanisms underlying cellular signaling.
  • Part I. In vitro protocols for studying expression and activity of cyclooxygenase enzymes and characterisation of their inhibition patterns -- 1. In vitro cyclo-oxygenase expression and activity protocols : introduction to Part I / Roderick J. Flower -- 2. Techniques used to study regulation of cyclooxygenase-2 promoter sites / Hiroyasu Inoue and Rieko Nakata -- 3. Purification of recombinant human COX-1 and COX-2 / James K. Gierse -- 4. Cloning and expression of cyclooxygenase-1 and cyclooxygenase-2 / Nicholas R. Staten and Beverly A. Reitz -- 5. Expression of cyclooxygenase isoforms in the baculovirus expression system / John C. Hunter, Natalie M. Myres, and Daniel L. Simmons -- 6. Peroxidase active site activity assay / Kelsey C. Duggan, Joel Musee, and Lawrence J. Marnett -- 7. Study of inhibitors of the PGH synthases for which potency Is regulated by the redox state of the enzymes / Olivier Boutaud and John A. Oates -- 8. Different methods for testing potential cyclooxygenase-1 and cyclooxygenase-2 inhibitors / Stefan Laufer and Sabine Luik -- 9. In vitro cyclooxygenase activity assay in tissue homogenates / Samir S. Ayoub -- 10. Techniques used to characterize the binding of cyclooxygenase Inhibitors to the cyclooxygenase active site / William F. Hood -- 11. In vitro Assays for cyclooxygenase activity and inhibitor characterization / Mark C. Walker and James K. Gierse -- -- Part II. Extraction and measurement of prostanoids and isoprostanes -- 12. Extraction and measurement of prostanoids and isoprostanes : introduction to Part II / Paola Patrignani -- 13. Prostanoid extraction and measurement / Lorenzo Polenzani and Samir S. Ayoub -- 14. Measurement of 8-iso-prostaglandin F2a in biological fluids as a measure of lipid peroxidation / Stefania Tacconelli, Marta L. Capone, and Paola Patrignani -- -- Part III. In vivo models to study involvement of cyclooxygenase products in health and disease -- 15. In vivo models to study cyclooxygenase products in health and disease: introduction to Part III / Derek W. Gilroy, Melanie Stables, and Justine Newson -- 16. Protocols to assess the gastrointestinal side effects resulting from inhibition of Cyclo-Oxygenase isoforms / Brendan J.R. Whittle -- 17. Cyclooxygenase enzymes and their products in the carrageenan-induced pleurisy in rats / Adrian R. Moore, Samir S. Ayoub, and Michael P. Seed -- 18. Iloprost-induced nociception : determination of the site of anti-nociceptive action of cyclooxygenase inhibitors and the Involvement of cyclooxygenase products in central mechanisms of nociception / Samir S. Ayoub and Regina M. Botting.
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  • "Cysteine proteases expressed by pathogenic organisms play key roles in virulence including host entry, feeding and suppression of host immune responses. This book gives comprehensive coverage to all aspects of pathogen cysteine proteases and brings together numerous scientific advances which have been made over many years. Thus, the biochemistry, molecular biology and structure function relationships of these important pathogen enzymes are covered in detail. Written by leading researchers from Europe, Australia and North America, this book is essential reading for students and professionals interested in human medicine and infectious disease research"--Provided by publisher.
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  • The CFTR gene: structure, mutations and specific therapeutic approaches / Nissim-Rafinia, M., Linde, L., Kerem, B. -- Exquisite and multilevel regulation of CFTR expression / Trezise, A.E.O. -- Intracellular processing of CFTR / Barriere, H., Lukacs, G.L. -- Structure of the cystic fibrosis transmembrane conductance regulator / Stratford, F.L.L., Bear, C.E. -- Function of CFTR protein: ion transport / Chen, J.-H. ... [et al.] -- Cystic fibrosis. Function of CFTR Protein: regulatory functions / Coakley, R.D., Stutts, M.J. -- Function of CFTR protein: developmental role / Gill, D., Larson, J.E. -- Genotype-phenotype correlations in cystic fibrosis / Dorfman, R., Zielenski, J. -- Diagnosis of cystic fibrosis, CFTR-related disease and screening / Karczeski, B.A., Cutting, G.R. -- CF modifier genes / Griesenbach, U., Alton, E.W.F.W., Davies, J.C. -- Animal models / Dorin, J.R -- In vitro/ex vivo fluorescence assays of CFTR chloride channel function / Verkman, A.S., Galietta, L.J.V. -- In vivo measurement of airway potential difference to assess CFTR function in man / Middleton, P., Alton, E.W.F.W. -- Arrays and proteomics / Ogilvie, V.C., MacGregor, G. -- Pathogenesis of pulmonary disease in cystic fibrosis / Mall, M., Boucher, R.C. -- Infection versus inflammation / Ziady, A.G., Davis, P.B. -- Pseudomonas aeruginosa: clinical research / Armstrong, D. -- Pseudomonas aeruginosa: basic research / Scott, F.W., Pitt, T.L. -- Other gram-negative organisms: Burkholderia cepacia complex and Stenotrophomonas maltophilia / Govan, J.R.W. -- Staphylococcus aureus and MRSA / Conway, S., Denton, M. -- Nontuberculous mycobacterial lung disease in patients with cystic fibrosis / Griffith, D.E -- Respiratory fungal infections and allergic bronchopulmonary aspergillosis / Que, C., Geddes, D. -- Advanced disease management and advances in transplant medicine / Carby, M.R., Hodson, M.E. -- Current and novel antimicrobial approaches / Davies, J.C. -- Anti-inflammatory agents: a clinical perspective / Hilliard, T.N., Balfour-Lynn, I.M. -- Recent advances in infant and pre-school lung function / Ranganathan, S. -- Recent advances in imaging / Oikonomou, A., Hansell, D.M. -- New pharmacological approaches for treatment of cystic fibrosis / Rubenstein, R.C. -- Gene and stem cell therapy / Boyd, A.C. -- Gut disease: clinical manifestations, pathophysiology, current and new treatments / Taylor, C.J., Hardcastle, J. -- Pancreatic involvement: clinical manifestations, pathophysiology and new treatments / Lindley, K.J. -- Cystic fibrosis: liver disease / Westaby, D. -- Fertility, contraception, incontinence and pregnancy / Thorpe-Beeston, J.G. -- Arthritis, vasculitis and bone disease / Elkin, S. -- Diabetes in cystic fibrosis / Bridges, N., Spowart, K. -- Challenges for nurses / Madge, S. -- Dietetics / Wolfe, S., Morton, A. -- Physiotherapy / Pryor, J.A. ... [et al.] -- Psychological interventions / Bryon, M. -- The future / Bush, A. ... [et al.].
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    History of cystic fibrosis / James M. Littlewood -- Epidemiology of cystic fibrosis / Sarah Walters and Anil Mehta -- Molecular biology of cystic fibrosis : CFTR processing and functions, and classes of mutations / Malka Nissim-Rafinia, Batsheva Kerem, and Eitan Kerem -- Pathophysiology : epithelial cell biology and ion channel function in the lung, sweat gland, and pancreas / Raymond D. Coakley and Richard C. Boucher -- Immunology of cystic fibrosis / Gerd Döring and Felix Ratjen -- Genotype-phenotype correlations and modifier genes / Jane C. Davies -- Variability of clinical course in cystic fibrosis / Michael Schechter -- Diagnosis of cystic fibrosis / Colin Wallis -- The challenge of screening newborn infants for cystic fibrosis / Kevin W. Southern -- How to manage the screened patient / Philip Robinson -- Microbiology of cystic fibrosis : role of the clinical microbiology laboratory, susceptibility and synergy studies, and infection control / Samiya Razvi and Lisa Saiman -- Respiratory disease : infection / Ian M. Balfour-Lynn and J. Stuart Elborn -- Respiratory disease : non-infectious complications / Margaret Hodson and Andrew Bush -- Sleep, lung mechanics, and work of breathing, including NIPPV / Brigitte Fauroux and Annick Clément -- Delivery of therapy to the cystic fibrosis lung / Harm A.W.M. Tiddens and Sunalene G. Devadason -- The upper airway in cystic fibrosis / William E. Grant -- Gastrointestinal disease in cystic fibrosis / Ian Gooding and David Westaby -- Liver, biliary, and pancreatic disease / Vicky Dondos and David Westaby -- Insulin deficiency and diabetes related to cystic fibrosis / Christopher D. Sheldon and Lee Dobson -- Growth and puberty / Nicola Bridges -- Cystic-fibrosis-related low bone mineral density / Sarah L. Elkin and Charles S. Haworth -- Other system disorders in cystic fibrosis / Khin Ma Gyi -- Sexual and reproductive health / Susan M. Sawyer -- Transplantation / Paul Aurora, Khin Gyi, and Martin Carby -- Using databases to improve care / Sheila G. McKenzie and Margaret E. Hodson -- Infant and pre-school children : lung function / Sarath Ranganathan -- Infant and pre-school children : role of bronchoscopy / Gary Connett -- Infant and pre-school children : imaging the lungs / Samatha Sonnappa and Catherine M. Owens -- Physiological monitoring of older children and adults / Mark Rosenthal -- Exercise : testing / David M. Orenstein and Wolfgang Gruber -- Exercise : use in therapy / David M. Orenstein and Linda W. Higgins -- Clinical outcome measures to assess new treatments for CF lung disease / Jane C. Davies and Eric W.F.W. Alton on behalf of the UKCF Gene Therapy Consortium -- Cystic fibrosis center care / Penny Agent and Susan Madge -- Nursing care / Susan Madge and Christine Hockings -- Physiotherapy / Craig Lapin, Anne Lapin, and Jennifer A. Pryor -- Nutritional aspects / Sue Wolfe and Sarah Collins -- Psychological aspects of cystic fibrosis / Alistair J.A. Duff and Helen Oxley -- Palliative care in cystic fibrosis / Catherine E. Urch and Margaret E. Hodson -- Gene and stem cell therapy / Uta Griesenbach and Eric W.F.W. Alton on behalf of the UKCF Gene Therapy Consortium -- Non-gene therapy treatments : what will they deliver? / Adam Jaffé and Pierre Barker -- The future : how will management change? / Andrew Bush and Duncan Geddes -- Transition form / Susan Madge and Jacqueline Francis -- Practical nursing care required by the cystic fibrosis patient and its delivery / Frances Duncan-Skingle and Tracey Catling.
  • Neurocysticercosis (neural infection by larvae of Taenia solium) occurs when humans become intermediate hosts of the tapeworm Taenia solium after ingesting its eggs, usually directly from a Taenia carrier. Nowadays, the disease is the most common helminthic infection of the nervous system in humans, and a major cause of acquired epilepsy. It has long been endemic in developing countries of Latin America, sub-Saharan Africa, the Indian subcontinent, and Southeast Asia. Recently, however, mass migration from endemic to non-endemic areas and growth in overseas travel have resulted in an increase in the prevalence of cysticercosis in countries where it was formerly considered exotic. The introduction of modern neuroimaging and serologic techniques has improved the diagnosis of neurocysticercosis, and the development of potent cysticidal drugs has changed the prognosis of most affected patients. Nevertheless, much remains to be learned about this parasitic disease. This book provides a comprehensive and up-to-date review of the various aspects of cysticercosis of the nervous system that will be of interest to all who are involved in the care of patients with the disease. Epidemiology, neuropathology, immunopathogenesis, clinical manifestations, diagnosis, and management are all thoroughly discussed based on current evidence and practice.
  • The book deals with various clinical aspects of cytochrome P450 2E1 (CYP2E1) which is a potent source for oxidative stress. Oxidative stress is critical for pathogenesis of diseases and CYP2E1 is a major contributor for oxidative stress. Several clinical disorders are associated with changes in regulation of CYP2E1 and the consequent abnormalities which include alcoholic liver disease, alcoholic pancreatitis, carcinogenesis, non-alcoholic fatty liver disease, non-alcoholic steatohepatitis, obesity, hepatitis C virus infection, reproductive organ toxicity, hepatocellular and cholestatic liver cirrhosis, inhibition of bone repair, cross-tolerance in smokers and people treated with nicotine, disorders of central nervous system, changes in metabolism of protoxicants in the circulatory system and susceptibility to human papillomavirus infection. Hence, CYP2E1 emerges as a new and potent player in aggravating injury and furthering disease complications.
  • Cytochrome P450 protocols. 2nd ed. 2005
    Springer Protocols
    Cytochrome P450 nomenclature, 2004 / David R. Nelson -- Spectral analyses of cytochromes P450 / John B. Schenkman and Ingela Jansson -- Establishment of functional human cytochrome P450 monooxygenase systems in Escherichia coli / Michael P. Pritchard, Lesley McLaughlin, and Thomas Friedberg -- Purification of cytochromes P450: products of bacterial recombinant expression systems / F. Peter Guengerich and Martha V. Martin -- Expression of recombinant flavin-containing monooxygenases in a baculovirus/insect cell system / Azara Janmohamed ... [et al.] -- Cytochrome P450 reconstitution systems / Hiroshi Yamazaki and Tsutomu Shimada -- Catalytic assays for human cytochrome P450: an introduction / Thomas K.H. Chang and David J. Waxman -- Enzymatic analysis of cDNA-expressed human CYP1A1, CYP1A2, and CYP1B1 with 7-ethoxyresorufin as substrate / Thomas K.H. Chang and David J. Waxman -- Spectrofluorometric analysis of CYP2A6-catalyzed coumarin 7-hydroxylation / David J. Waxman and Thomas K.H. Chang -- Determination of CYP2B6 component of 7-ethoxy-4-trifluoromethylcoumarin O-deethylation activity in human liver microsomes / Thomas K.H. Chang, Charles L. Crespi, and David J. Waxman -- High-performance liquid chromatography analysis of CYP2C8-catalyzed paclitaxel 6[alpha]-hydroxylation / Charles L. Crespi, Thomas K.H. Chang, and David J. Waxman -- Determination of CYP2C0-catalyzed diclofenac 4'-hydroxylation by high-performance liquid chromatography / Charles L. Crespi, Thomas K.H. Chang, and David J. Waxman -- CYP2C19-mediated (S)-mephenytoin 4'-hydroxylation assayed by high-performance liquid chromatography with radiometric detection / Charles L. Crespi, Thomas K.H. Chang, and David J. Waxman -- CYP2D6-dependent bufuralol 1'-hydroxylation assayed by reverse-phase ion-pair high-performance liquid chromatography with fluorescence detection / Charles L. Crespi, Thomas K.H. Chang, and David J. Waxman -- Spectrophotometric analysis of human CYP2E1-catalyzed p-nitrophenol hydroxylation / Charles L. Crespi, Thomas K.H. Chang, and David J. Waxman -- Thin-layer chromotography analysis of human CYP23A-catalyzed testosterone 6[beta]-hydroxylation / David J. Waxman and Thomas K.H. Chang -- Determination of CYP4A11-catalyzed lauric acid 12-hydroxylation by high-performance liquid chromotography with radiometric detection / Charles L. Crespi, Thomas K.H. Chang, and David J. Waxman -- An isocratic high-performance liquid chromatography assay for CYP7A1-catalyzed cholesterol 7[alpha]-hydroxylation / David Waxman and Thomas K.H. Chang -- Use of 7-ethoxycoumarin to monitor multiple enzymes in the human CYP1, CYP2, and CYP3 families / David J. Waxman and Thomas K.H. Chang -- Benzydamine N-oxygenation as a measure of flavin-containing monooxygenase activity / Catherine K. Yeung and Allan E. Rettie -- Prochiral sulfoxidation as a probe for flavin-containing monooxygenases / Catherine K. Yeung and Allan E. Rettie -- Targeting antipeptide antibodies toward cytochrome P450 enzymes / Robert J. Edwards -- The Human Cytochrome P450 Allele Nomenclature Committee web site: submission criteria, procedures, and objectives / Sarah C. Sim and Magnus Ingelman-Sundberg -- Genotyping for cytochrome P450 polymorphisms / Ann K. Daly, Barry P. King, and Julian B.S. Leathart -- Hepatocyte cultures in drug metabolism and toxicological research and testing / Tamara VanHaecke and Vera Rogiers -- Isolation of rat hepatocytes / Peggy Papeleu ... [et al.] -- Rat hepatocyte cultures: conventional monolayer and cocultures with rat liver epithelial cells / Tom Henkens ... [et al.] -- Rat hepatocyte cultures: collagen gel sandwich and immobilization cultures / Mathieu Vinken ... [et al.] -- Hepatocytes in suspension / Greetje Elaut ... [et al.] -- Isolation of rat bone marrow stem cells / Sarah Snykers, Tamara Vanhaecke, and Vera Rogiers -- Transfection of primary cultures of rat hepatocytes / Mina Edwards -- Human hepatocyte culture / Lydiane Pichard ... [et al.] -- Determination of cellular localization of the expression of flavin-containing monooxygenase genes in mouse tissues by in situ hybridization / Azara Janmohamed, Ian R. Phillips, and Elizabeth A. Shephard -- Deletion of genes from the mouse genome using cre/loxP technology / Diana Hernandez ... [et al.] -- Characterization of targeted mouse embryonic stem cell chromosomes: karyotyping and fluorescence in situ hybridization of metaphase spreads / Diana Hernandez, Ian R. Phillips, and Elizabeth A. Shephard -- Microinjection of targeted embryonic stem cells and establishment of knockout mouse lines for fmo genes / Diana Hernandez ... [et al.] -- Use of reporter genes to measure xenobiotic-mediated activation of CYP gene transcription / Nick Plant.
  • This authoritative Fourth Edition summarizes the advances of the past decade concerning the structure, mechanism, and biochemistry of cytochrome P450 enzymes, with sufficient coverage of earlier work to make each chapter a comprehensive review of the field. Thirteen chapters are divided into two detailed volumes, the first covering the fundamentals of cytochrome P450 biochemistry, as well as the microbial, plant, and insect systems, and the second exclusively focusing on mammalian systems. Volume 1 begins with an exploration of the biophysics and mechanistic enzymology of cytochrome P450 enzymes, with a discussion of the structures of P450 enzymes and their electron donor partners, the mechanisms of oxygen activation and substrate oxidation, and the approaches and nature of cytochrome P450 inhibition. Two more chapters discuss the nature and roles of cytochrome P450 enzymes in microbes, plants and insects, and an eighth chapter is a survey of the potential utility of P450 enzymes in biotechnology. The first chapter of Volume 2 examines the roles of P450 enzymes in mammals, mainly humans. Four further chapters then deal with the genetic and hormonal regulation of P450 enzymes and their specific roles in the processing of sterols and lipids. Cytochrome P450: Structure, Mechanism, and Biochemistry is a key resource for scientists, professors, and students interested in fields as diverse as biochemistry, chemistry, biophysics, molecular biology, pharmacology and toxicology.
  • Cytochrome P450. Part C 2002
  • The Interleukin-1 Family / Charles A. Dinarello and Mihai G. Netea -- IL-6 and Inflammatory Diseases / Daisuke Kamimura, Yasunobu Arima, Toshio Hirano, Hideki Ogura, and Masaaki Murakami -- The Roles of IL-17A and IL-17F in Infection and Inflammatory Disorders / Harumichi Ishigame and Susumu Nakae -- IL-18 / Wen Li, Yoshimasa Tanaka, and Haruki Okamura -- Interleukin-21: a Pleiotropic Mediator of Immunity and Inflammation with Broad Therapeutic Potential / Rosanne Spolski and Warren J. Leonard -- Interleukin-22: A Bridge Between Epithelial Innate Host Defense and Immune Cells / Xiaoting Wang and Wenjun Ouyang -- IL-23 in Health and Disease / Jonathan P. Sherlock, Luis A. Zuniga, and Daniel J. Cua -- IL-36: An Epithelial Cytokine Important in Psoriasis / John E. Sims, Solenne Vigne, Cem Gabay, and Jennifer E. Towne -- Anti-TNF Therapy: 20 Years from Our First Therapeutic Adventure / Jagdeep Nanchahal, Peter Taylor, Richard Williams, and Marc Feldmann -- Interleukin-25: Key Initiator of Type 2 Immune Responses / Hiroshi Nakajima, Tomohiro Tamachi, and Koichi Hirose -- Interleukin-33: Multifunctional Alarmin that Promotes Both Health and Disease / Kazufumi Matsushita and Tomohiro Yoshimoto -- Thymic Stromal Lymphopoietin (TSLP) / Steven F. Ziegler, Florence Roan, Bryan D. Bell, Thomas A. Stoklasek, Masayuki Kitajima, and Hongwei Han -- Interleukin-10: Cytokines in Anti-inflammation and Tolerence / Ashleigh Howes, Philippa Stimpson, Paul Redford, Leona Gabrysova, and Anne O'Garra -- Interleukin-27: Regulation of Immune Responses and Disease Development by a Pleiotropic Cytokine with Pro- and Anti-inflammatory Properties / Izuru Mizoguchi, Kaname Higuchi, Kana Mitobe, Ren Tsunoda, Junichiro Mizuguchi, and Takayuki Yoshimoto -- Interleukin-35: A Novel Mediator of Peripheral Tolerance / Greg M. Delgoffe and Dario A.A. Vignali.
  • The biology of cytokines : general principles, properties and lessons from animal models / Davide Agnello and Massimo Gadina -- Genetics of multifactorial disorders / Jorge R. Oksenberg and John D. Rioux -- Statistical approaches to analysis of polymorphisms in multifactorial disorders / An Goris and Mariza de Andrade -- Introduction to integrated bioinformatic resources for cytokine genetics research / Ross Lazarus -- Cytokine gene nucleotide sequence alignments / Jeffrey Bidwell -- SNP genotyping techniques / Pui-Yan Kwok -- The IL1 cluster / Tanja Pessi ... [et al.] -- IL-2 biology and polymorphisms in multifactorial conditions / Fuencisla Matesanz, María Fedetz, and Antonio Alcina -- The chromosome 5q23.1-q 31.1 cluster of cytokines / Tarja Laitinen -- IL10 / Ross Lazarus --; The IL19 subfamily of cytokines / Sulev Kõks ... [et al.] -- The IFNG-IL26-IL22 cytokine gene cluster / Koen Vandenbroeck and An Goris -- TNF polymorphisms and disease / Reginald M. Gorczynski and Ivo Boudakov -- Macrophage migration inhibitory factor (MIF) / Zaynab Alourfi, David W. Ray, and Rachelle Donn -- Polymorphisms of chemokines and their receptors / Bénédicte Puissant, Christophe Combadière, and Elise Lavergne -- Asthma and atopy / Jussi Karjalainen ... [et al.] -- Common rheumatic diseases / Rachael Kilding and Anthony G. Wilson -- Systemic lupus erythematosus / Sandra D'Alfonso -- Sjögren's syndrome / Marja Pertovaara -- Multiple sclerosis / Orhun H. Kantarci and Brian G. Weinshenker --; Type 1 and 2 diabetes / Regine Bergholdt and Flemming Pociot -- Psoriasis / Sulev Kõks ... [et al.] -- Diseases of the gastrointestinal tract / Thomas Höhler -- Pulmonary fibrosis / Berran Yucesoy and Michael I. Luster -- Atherosclerosis / Giuseppina Candore ... [et al.] -- Longevity / Irene Maeve Rea ... [et al.] -- AIDS / Alexandre Vasilescu, Hervé Do, and Jean-Francois Zagury -- Tropical infectious diseases / Thereza Quirico-Santos ... [et al.] -- Suseptibility to infection and severe disease in schistosomiasis / Violaine Arnaud and Christophe Chevillard.
  • Cytokines 2011
    1. General and cellular aspects -- 2. Life style factor and life events -- 3. Immunology and infections -- 4. Cancer -- 5. Cardiovascular and metabolic disease -- 6. Organs and tissue systems.
  • Cytokines and the brain 2008
  • Print Material
  • Introduction to cytokines as targets for immunomodulation / Theresa L. Whiteside -- Cytokine measurement tools for immunotoxicology / Rob J. Vandebriel -- The relevance of the T1/T2 paradigm in immunotoxicology: example of drug hypersensitivity reactions / Hervé Lebrec and John Vasilakos -- Microbial exploitation and subversion of the human chemokine network / James E. Pease -- The use of cytokines in the identification and characterization of chemical allergens / Rebecca J. Dearman and Ian Kimber -- Inflammatory cytokines and lung toxicity / Debra L. Laskin ... [et al.] -- Cytokine polymorphisms and relationship to disease / Berran Yucesoy ... [et al.] -- Effects of drugs of abuse on cytokine responses / Stephen B. Pruett -- Preclinical approaches for safety assessment of cytokines / Peter T. Thomas and Melissa S. Beck-Westermeyer -- Flu-like syndrome and cytokines / Jacques Descotes and Thierry Vial -- Cytokine-induced vascular leak syndrome / Roxana G. Baluna -- Cytokines and autoimmune diseases: from the control of autoimmune diseases with anti-cytokine treatment to the induction of autoimmunity with cytokine treatment / Pierre Miossec -- Evaluation of antibodies in clinical trials of cytokines / Steven Swanson -- Cytokines and pharmacokinetic drug interactions / Kenneth W. Renton -- Evaluation of the immunological effects of cytokines administered to patients with cancer / Michael J. Robertson -- Clinical adverse effects of cytokines on the immune system / Thierry Vial and Jacques Descotes.
  • Helicobacter pylori and cytokines in the genesis of gastric cancer / Richard M. Peek, Jr. -- HTLV-1, cytokines, and cancer / Michael Lairmore and Lee Ratner -- Herpesviruses, cytokines, and cancer / Frank J. Jenkins and Heather R. Hensler -- Tumor necrosis factor and cancer / Mark DeWitte ... [et al.] -- Transforming growth factor-[beta] and cancer / Alyssa R. Bonine-Summers, Brian K. Law, and Harold L. Moses -- Interleukin-1 family of cytokines and cancer / Michael T. Lotze--Interleukin-4/13 and cancer / Koji Kawakami and Raj K. Puri -- Interleukin-6 and Castleman's disease / Norihiro Nishimoto -- Interleukin-10 (IL-10): biology, immune, regulation, and cancer / Shin-ichiro Fujii and Michael T. Lotze -- Cytokines in multiple myeloma: therapeutic implications / Dharminder Chauhan, Teru Hideshima, and Kenneth C. Anderson -- In vivo murine cytokine models and the genesis of cancer / Todd A. Fehniger, Megan A. Cooper, Michael A. Caligiuri -- Experimental models of cytokines and cancer prevention / Mark J. Smyth ... [et al.] -- Cytokines in the tumor stroma / Michael C. Ostrowski -- Cytokines and tumor angiogenesis / Sharmila Roy-Chowdhury and Charles K. Brown -- Chemokine and receptor expression in tumor progression / Paola Allavena, Federica Marchesi, and Alberto Mantovani -- The biology of cancer cachexia and the role of TNF-[alpha] / Denis C. Guttridge -- Interleukin-2 and cancer therapy / Kim Margolin and Joseph Clark -- Interleukin-12 and cancer therapy / Timothy E. Bael and Jared Gollob -- The type I interferon system with emphasis on its role in malignancies: interferons are more than "antivirals" / Stergios J. Moschos ... [et al.] -- Combination cytokine therapy / Seth M. Cohen and Howard L. Kaufman -- Novel strategies for cytokine administration via targetting / Paul M. Sondel ... [et al.] -- Cytokines and cancer vaccines / Hideho Okada and Michael T. Lotze -- Anticytokine therapy / Miguel A. Villalona-Calero -- Cytokines in the supportive care of cancer / John A. Glaspy.
  • 1. Behavioral Effects of Cytokines: A Psychiatrist's Perspective / Ziad Kronfol -- 2. Worried to Death? Stress, Worry, and Immune Dysregulation in Health and HIV -- 3. Psychological Stress and Its Relationship to Cytokines and Inflammatory Diseases / Rama Murali, Margaret D. Hanson, and Edith Chen -- 4. Role of Cytokines in Depression / Ghanshyam N. Pandey and Yogesh Dwivedi -- 5. Loneliness, Dysphoria, Stress, and Immunity: A Role for Cytokines / Louise C. Hawkley, Jos A. Bosch, Christopher G. Engeland, Phillip T. Marucha, and John T. Cacioppo -- 6. Stress, Cytokines, and Peripheral Analgesia / Peter John Cabot -- 7. Alexithymia, Stress, and Immunity / Olivier Guilbaud, Maurice Corcos, and Philippe Jeammet -- 8. Roles of Mu-Opioid Receptor and Endogenous Opiates in Stress-Induced Immunosuppression / Jennifer Kelschenbach, Horace H. Loh, and Sabita Roy -- 9. Stress, Opioid Peptides, and Immune Reponse / Javier Puente, Marion E. Wolf, M. Antonieta Valenzuela, and Aron D. Mosnaim -- 10. Met-Enkephalin in Oxidative Stress / Tihomir Balog, Sandra Soboc̆anec, Vis̆nja S̆verko, Helena Haberstock-Debić, and Tatjana Marotti -- 11. Chronic Stress Induces Death of Lymphocytes / Erwei Sun, Lixin Wei, Arthur I. Roberts, Catherine Liu, and Yufang Shi -- 12. Interleukin-10 and the Hypothalamic--Pituitary--Adrenal Axis / Eric M. Smith, Huolin Tu, and Thomas K. Hughes, Jr. -- 13. Cytokines, Stress, and Depression / Adrian J. Dunn -- 14. Immunoconversion in Acute Phase Response / Istvan Berczi, Andres Quintanar-Stephano, and Kalman Kovacs -- 15. Interferon in Health and Disease / Nachum Dafny, Pamela B. Yang, and Stanley A. Brod -- 16. Neuropeptide Precursor Processing in Immunocytes: Involvement in Neuroimmune Communication / Robert Day and Michel Salzet -- 17.Clinical Relevance of Opioid-Induced Immunosuppression: Are All Drugs Similar? / Paola Sacerdote, Sivia Franchi, and Cataldo Martucci -- 18. Human Retroviruses and the Cytokine Network / Massimo Alfano and Guido Poli -- 19. Psychiatric Toxicity of Interferon: A Model for Understanding the Etiology of Major Depression and Chronic Fatigue Syndrome? -- 20. Role of Genetic Predisposition, Cytokines, and Neuroendocrine Response in Development of Thyroid Autoimmunity / Antonio Martocchia and Paolo Falaschi -- 21. Gender Differences, Stress, and Immunity / Nicholas P. Plotnikoff and Robert E. Faith.
  • An overview of physical growth and maturation / Hills, A.P., Byrne, N.M. -- Role of various cytokines and growth factors in pubertal development / Casazza, K., Hanks, L.J., Alvarez, J.A. -- Body composition differences in normal weight, obese-overweight, and anorexic adolescents : role of adipocytokines / Ondrak, K.S., Hackney, A.C. -- Inflammatory cytokines and metabolic risk factors during growth and maturation : influence of physical activity / Rubin, D.A., Hackney, A.C. -- Visfatin and adiponectin levels in children : relationships with physical activity and metabolic parameters / Mäestu, J., Jürimäe, J., Jürimäe, T. -- Ghrelin and obestatin concentrations during puberty : relationships with adiposity, nutrition, and physical activity / King, N.A., Gibbons, C.H., Martins, C. -- Menstrual irregularities and energy deficiency in physically active women : the role of ghrelin, PYY, and adipocytokines / Scheid, J.L., De Souza, M.J. -- Influence of ghrelin and adipocytokines on bone mineral density in adolescent female athletes with amenorrhea and eumenorrheic athletes / Russell, M., Misra, M. -- Bone turnover markers during pubertal development : relationships with growth factors and adipocytokines / Jürimäe, J., Mäestu, J., Jürimäe, T. -- Exercise training, physical fitness, and the growth hormone-insulin-like growth factor-1 axis and cytokine balance / Eliakim, A., Nemet, D. -- Growth hormone-insulin-like growth factor-1 and inflammatory response to a single exercise bout in children and adolescents / Nemet, D., Eliakim, A. -- Effect of acute and chronic exercise on ghrelin and adipocytokines during pubertal development / Kraemer, R.R., Castracane, V.D.
  • Normal histology of female genital organs -- Lesions of the vulva and vagina -- Squamous lesions of the cervix -- Glandular lesions of the cervix -- Human papillomavirus for cervical pathology -- Endometrial epithelial neoplasms -- Nonepithelial tumors of uterine corpus -- Gestational trophoblastic disease -- Tumors of fallopian tube and broad ligament -- Epithelial neoplasms of ovary -- Nonepithelial tumor of ovary -- Tumors of peritoneum.
  • Print Material
    Cervical and vaginal cytology / Edmund S. Cibas -- Respiratory tract / Christopher A. French -- Urine and bladder washings / Andrew A. Renshaw -- Pleural, pericardial, and peritoneal fluids / Edmund S. Cibas -- Peritoneal washings / Edmund S. Cibas -- Cerebrospinal fluid / Edmund S. Cibas -- Gastrointestinal tract / David W. Kindelberger and Helen H. Wang -- Breast / Barbara S. Ducatman and Helen H. Wang -- Thyroid / Edmund S. Cibas -- Salivary gland / Jeffrey F. Krane and William C. Faquin -- Lymph nodes / Paul E. Wakely, Jr., and Edmund S. Cibas -- Liver / Barbara S. Ducatman -- Pancreas and biliary tree / Jian Shen and David W. Kindelberger -- Kidney and adrenal gland / Andrew A. Renshaw and Edmund S. Cibas -- Ovary / Edmund S. Cibas -- Soft tissue / Xiaohua Qian -- Laboratory management / Edmund S. Cibas.
  • Fully updated, the 4th edition of Cytology helps you apply the latest diagnostic techniques for the interpretation of a complete range of cytological specimens. This medical reference book offers access to the newest methods and adjunct tests, all in a brief, highly readable format that makes quick work of reviewing the key information available on this powerful yet minimally invasive method. It's a perfectly practical bench manual for trainees and practicing pathologists. Take advantage of comprehensive yet concise coverage of nearly every type of cytology, including gynecologic, non-gynecologic, and FNA. Understand the clinical implications of your diagnoses and better equip yourself to make effective interpretations with clinical correlations emphasized throughout. Make the most informed reporting decisions through an in-depth analysis of common diagnostic pitfalls. Quickly find the answers you need with succinct, bulleted text, clinical pearls, and summaries of key points. Gain real-life perspective on a complete range of cytologic findings with over 700 full-color illustrations.
  • Cytopathology: An Introduction is a succinct book which guides the trainee through the hurdles of early cytology practice and can also be used throughout the career as an aide memoire by the more experienced. With numerous illustrations to enthuse the reader and make cytological practice a more enjoyable and educational experience, Cytopathology: An Introduction also highlights points of diagnostic difficulty, particularly with regard to the differentiation of neoplastic from non-neoplastic disease. Each chapter of Cytopathology: An Introduction starts by detailing the main methods available appropriate to the clinical situation, followed by descriptions of the relevant cytological appearances and diagnostic pitfalls. Topics covered include the brain and cerebrospinal fluid; pulmonary cytology; serous fluids; thyroid gland; lymph nodes; salivary glands; gastrointestinal and hepatopancreaticobiliary tracts; urinary tract and retroperitoneal cytology; female genital tract; breast; soft tissue, bones and joints; and skin. Cytopathology: An Introduction will be an invaluable reference guide to histo- and cytopathology trainees, as well as those preparing for post-graduate examinations and consultants who want a refresher. A quick reference, concise but precise, Cytopathology: An Introduction provides practical and helpful information on the salient cytological features of any condition that may present in routine cytopathology.
  • In recent decades, cytopathology has assumed an increasing role in the primary diagnosis of mass lesions owing to its ability to provide rapid, non-invasive, and timely information. With cytopathology at the forefront of diagnosis and prognostication of neoplastic lesions, it is essential that physicians involved in the diagnosis and treatment of precancerous lesions and cancer have a clear understanding of specimen collection techniques, terminology for reporting, and outcomes in various diagnostic categories. This book provides a comprehensive overview of the role of cytology at various body sites. The diagnostic details covered are abbreviated in comparison with those in pathology texts. Instead, a more clinical approach is taken, with the focus on the advantages and limitations of techniques and the key features of entities that are important to clinicians. Pathological clinical correlation is highlighted throughout the book, ensuring that it will be highly relevant for clinicians. In particular, physicians who deal with oncology patients will find it to be a rich source of guidance on how to use and understand cytopathology in the diagnosis and exclusion of malignancy.
  • Introduction -- Specimen Collection and Handling -- Host Reactions to Infection -- Microbiology -- Gynecological Infections -- Pulmonary Infections -- Gastrointestinal and Hepatobiliary Infections -- Urinary Tract Infections -- Central Nervous System Infections -- Hematologic Infections -- Breast, Skin, and Musculoskeletal Infections -- Head and Neck Infections -- Immunosuppressed Host -- Ancillary Investigations -- Mimics and Contaminants.
  • This volume fulfills the need for an easy-to-use and authoritative synopsis of intra-abdominal organ cytopathology. Part of the Essentials in Cytopathology book series, the book is heavily illustrated with a full color art program, while the text follows a user-friendly outline format. The book also fits into the lab coat pocket and is ideal for portability and quick reference. Written by authorities in the field, Cytopathology of the Liver, Biliary Tract, Kidney and Adrenal Glands is a concise and valuable resource to pathologists on the subject of intra-abdominal organ cytopathology.
  • & Quot;Soft Tissue Cytopathology" by Anil V. Parwani, MD, PhD and Walid E. Khalbuss, MD, PhD, will fulfill the need for an easy-to-use and authoritative synopsis of soft tissue cytopathology. This volume, part of "The Essentials in Cytopathology book series," fits into the lab coat pocket and is ideal for portability and quick reference. Each volume in the series is heavily illustrated with a full color art program, while the text follows a user-friendly outline format. Anil V. Parwani, MD, PhD, is Associate Professor of Pathology at the University of Pittsburgh Medical Center - S.
  • Cytopathological techniques for the diagnosis of glandular lesions of the genital tract -- Bethesda System Classification of glandular lesions on cervical cytology -- Cytopathology of the benign glandular lesions of the cervix and glandular cytopathology of the vagina -- Cytopathology of adenocarcinoma in situ of the endocervix and its differential diagnosis -- Cytopathology of the malignant invasive lesions of the endocervix -- Endometrial hyperplasias -- Endometrial adenocarcinoma : current status and future of prevention and early diagnosis -- Cytopathology of ovarian lesions : the intraoperative approach -- Glandular lesions of the vulva -- Glandular lesions of the fallopian tube -- Metastatic glandular lesions -- Ancillary techniques for the diagnosis of glandular lesions of the female genital tract
  • Cytopreparation: Principles & Practice by Gary W. Gill fills a long-standing need for an easy-to-use and authoritative manual on the fundamentals of cytopreparation up-to-and- including microscopy, screening, and data analysis. The text describes in phenomenological terms the most common materials and methods of specimen collection through mounting for gyn, non-gyn, and FNA specimens, as well as the underlying mechanistic bases. The author provides his expertise and information that will empower and enable readers to review and improve their laboratories' cytopreparatory techniques as they apply to the vast majority of specimens. This unique volume provides facts that are not readily available anywhere. Cytopreparation: Principles & Practice is intended for everyone associated with, and involved in, making cytologic preparations that are useful for their intended purpose. It will serve as a valuable reference tool for educators in cytology and histology, cytotechnology and histotechnology students, cytotechnologists, cytopreparatory technicians, cytopathologists, anatomical/clinical pathologists, pathology residents and cytopathology fellows.
  • Part 1. Basics of the Cytoskeleton -- ACTIN / Vera Dugina, Richard Arnoldi, Paul A. Janmey and Christine Chaponnier -- Microtubules / Pavel Dráber and Eduarda Dráberová -- The Kinesin Superfamily / Linda Wordeman -- Basics of the Cytoskeleton: Myosins / Omar A. Quintero, Judy E. Moore and Christopher M. Yengo -- Part 2. Actin and Disease -- The Actin Cytoskeleton and Membrane Organisation in T Lymphocytes / Rhea Cornely, Thomas Grewal and Katharina Gaus -- Thin Filament Diseases of Striated Muscle / Anthony J. Kee and Edna C. Hardeman -- Filamins and Disease / Stephen P. Robertson and Philip B. Daniel -- LIM Kinase and Cancer Metastasis / Alice Schofield and Ora Bernard -- Actin Mutations and Deafness / Matías Morín, Fernando Mayo, Felipe Moreno and Miguel A. Moreno-Pelayo -- Therapeutic Targeting of the Actin Cytoskeleton in Cancer / Teresa Bonello, Jason Coombes, Galina Schevzov, Peter Gunning and Justine Stehn -- Part 3. Microtubules and Disease -- Microtubules as a Target in Cancer Therapy / April L. Risinger and Susan L. Mooberry -- Microtubules, Drug Resistance, and Tumorigenesis / Joshua A. McCarroll and Maria Kavallaris -- Posttranslational Modifications of Tubulin / Suzan K. Chao, Chia-Ping H. Yang and Susan Band Horwitz -- Stathmin and Cancer / Dominic Chi Hiung Ng and Frances Byrne -- The Biology and Pathobiology of Tau Protein / Garth F. Hall -- Tubulin-Related Malformations of Cortical Development / Xavier H. Jaglin, Jamel Chelly and Nadia Bahi-Buisson -- Part 4. Intermediate Filaments and Disease -- Spectrins in Human Diseases / Marie-Christine Lecomte -- Laminopathies / Nadir M. Maraldi and Giovanna Lattanzi -- Desmin and Heart Disease / J. Scott Pattison and Jeffrey Robbins -- Neurodegenerative Diseases and Intermediate Filaments / Rodolphe Perrot and Jean-Pierre Julien.
  • Central axonal development and pathology in early life / Robin L. Haynes and Hannah C. Kinney -- Microtubules in the nervous system / Nobuyuki Fukushima -- Tau phosphorylation / Jesús Avila and Félix Hernández -- Tau pathology / Nicolas Sergeant and Luc Buée -- Tauopathy and brain aging / Akihiko Takashima -- Microtubule-associated protein 4 / Kiyotaka Tokuraku ... [et al.] -- Structure of neural intermediate filaments / David A.D. Parry -- Alpha-internexin: the fourth subunit of neurofilaments in the mature CNS / Aidong Yuan and Ralph A. Nixon -- Peripherin pathology / Jesse R. McLean and Janice Robertson -- Neurofilament cross-bridge: a structure associated specifically with the neurofilament among the intermediate filament family / Takahiro Gotow -- Neurofilament transport / Andrew J. Grierson and Christopher C.J. Miller -- Knockout models of neurofilament proteins / Rodolphe Perrot and Jean-Pierre Julien -- Neurofilaments and radial growth: deconstruction of a hypothesis through the construction of gene targeted mice / Michael L. Garcia and Devin M. Barry -- Deregulation of cytoskeletal protein phosphorylation and neurodegeneration / Jyotshnabala Kanungo ... [et al.] -- Neurofilaments in aged animals / Shin-ichi Hisanaga, Takahiro Sasaki, and Atsuko Uchida -- Neurofilament changes in multiple sclerosis / Elizabeth Gray and Alastair Wilkins -- Intermediate filament interactions in neurons / Kevin G. Young and Rashmi Kothary -- Tropomyosins in neuronal morphogenesis and development / Nikki Margarita Curthoys, Peter William Gunning, and Thomas Fath -- The driving machinery for growth cone navigation / Takuro Tojima and Hiroyuki Kamiguchi -- Glial fibrillary acidic protein: the intermediate filament protein of astrocytes / Douglas L. Eng and Lawrence F. Eng -- Axonal transport mechanisms in cytoskeleton formation and regulation / Aidong Yuan and Ralph A. Nixon -- Axonal transport and motor neuron disease / Anna-Lena Ström ... [et al.] -- In vivo imaging of axonal transport in aging and Alzheimer's disease / Donna J. Cross and Satoshi Minoshima -- Regulation of cytoskeletal composition in neurons: transcriptional and post-transcriptional control in development, regeneration, and disease / Ben G. Szaro and Michael J. Strong -- Crosstalks between myelinating cells and the axonal cytoskeleton / Rodolphe Perrot and Joël Eyer -- Topographic regulation of neuronal intermediate filament proteins by phosphorylation: in health and disease / Parvathi Rudrabhatla and Harish C. Pant -- Cytoskeleton, axonal transport, and the mechanisms of axonal neuropathy / Hsinlin T. Cheng ... [et al.] -- Effects of insulin on tau and neurofilament / R. Schechter and K.E. Miller -- Ethanol effects on the cytoskeleton of nerve tissue cells / Sergio G. Evrard and Alicia Brusco.

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A repository of medical knowledge from internal medicine, cardiology, genetics, pharmacy, diagnosis and management, basic sciences, patient care, and more. Continuously expanding, all databases in the repository contain the latest editions of selected medical titles.MicroMedex: Premier pharmaceutical information source containing multiple databases and drug reference tools. Of particular value is DRUGDEX Evaluations, one of the most comprehensive drug sources available.DynaMed is a clinical information resource used by physicians to answer clinical questions quickly and easily at the point of care. Topics are updated daily as new evidence becomes available. Scopus is the largest abstract and citation database of peer-reviewed literature: scientific journals, books and conference proceedings.A drug information resource containing: American Hospital Formulary System (AHFS), drug formulary for Lucile Packard Children's Hospital (LPCH) and Stanford Hospital & Clinics (SHC), Lexi-Drugs (adverse reactions, dosage and administration, mechanism of action, storage, use, and administration information), Lexi-Calc, Lexi-ID, Lexi-I.V. Compatibility (King Guide), Lexi-Interact, and Lexi-PALS.Cumulative Index to Nursing and Allied Health Literature (CINAHL) contains coverage of nursing and allied health literature.A knowledge database that provides access to topic reviews based on over 6000 clinically relevant articles. The evidence-based content, updated regularly, provides the latest practice guidelines in 59 medical specialtiesProvides critical assessments of systematic reviews compiled from a variety of medical journals.Selects from the biomedical literature original studies and systematic reviews that are immediately clinically relevant and then summarizes these articles in an enhanced abstract with expert commentary.Multidisciplinary coverage of over 10,000 high-impact journals in the sciences, social sciences, and arts and humanities, as well as international proceedings coverage for over 120,000 conferences. Includes cited reference searching, citation maps, and an analyze tool.Features systematic reviews that summarize the effects of interventions and makes a determination whether the intervention is efficacious or not. Cochrane reviews are created through a strict process of compiling and analyzing data from multiple randomized control trials to ensure comprehensiveness and reliability.Provides systematic coverage of the psychological literature from the 1800s to the present through articles, book chapters and dissertations.BMJ Clinical Evidence. A clinical information tool built around systematic reviews summarizing the current state of knowledge about prevention and treatment of clinical conditions.PIER (Physicians' Information and Education Resource) is a Web-based decision-support tool designed for rapid point-of-care delivery of up-to-date, evidence-based guidance for primary care physicians.Cochrane Central Register of Controlled Trials (CENTRAL) provides access to 300,000 controlled trials that have been identified the Cochrane Collaboration.Provides drug information targeted for patients.A continually updating drug monograph.The National Guideline Clearinghouse (NGC): A comprehensive database of evidence-based clinical practice guidelines and related documents.MedlinePlus: A repository of health information from the National Library of Medicine. Links are from trusted sites. No advertising, no endorsement of commercial companies or productsLPCH CareNotes via MicroMedex: Patient education handouts customized by LPCH clinical staffMicromedex Lab Advisor: Evidence based laboratory test informationA drug database organized by generic name, trade name and drug class.LPCH / Stanford Hospital Formulary.A goldmine of trusted consumer health information from the world's largest medical library.A trusted source of expert advice for and about kids, providing the information necessary to help patients and parents understand their unique needs.Provides patient handouts from the American Academy of Family Physician.Access to the Stanford Health Library for patients.Lane provides access to over 5,000 eBooks many of which provide helpful background material that will prepare you to better tackle primary literature.Largest, broadest eBook package; covers all sciences, as well as technology (including software), medicine, and humanities. In addition to covering Wiley and Springer, MyiLibrary is also the only provider for Oxford and Cambridge University Press titles. No seat restrictions.A collection of biomedical books that can be searched directly by concept, and linked to terms in PubMed abstracts.A web-based, decision support system for infectious diseases, epidemiology, microbiology and antimicrobial chemotherapy. The database, updated weekly, currently includes 337 diseases, 224 countries, 1,147 microbial taxa and 306 antibacterial (-fungal, -parasitic, -viral) agents and vaccines. Over 10,000 notes outline the status of specific infections within each country.
Large number of high quality software and database programming titles from O'Reilly. Other software titles are also available from Sams and Prentice Hall. Limited to 7 concurrent users.Vast collection of software and database programming titles from multiple publishers, including Microsoft Press.Largest provider of engineering-related eBooks; includes titles in computer science and biomedical engineering.Over 4,000 full-text e-books covering scientific and technical information from CRC Press and others. Many handbooks and single volume reference sources.Includes peer-reviewed life science and biomedical research protocols compiled from Methods in Molecular Biology, Methods in Molecular Medicine, Methods in Biotechnology, Methods in Pharmacology and Toxicology, Neuromethods, the Biomethods Handbook, the Proteomics Handbook, and Springer Laboratory Manuals.Contains full text access to selected biomedical and nursing books.Provides online, full-text access to Springer's journal titles as well as journals from other publishers. Subjects include: life sciences, chemical sciences, environmental sciences, geosciences, computer science, mathematics, medicine, physics and astronomy, engineering and economics. Also includes eBooks.Collection of over 8 thousand fulltext titles in engineering, math, and basic and applied biomedical research. Coverage is from 1967 to the present.A library of ebooks on a wide array of topics, digitized and made available online in conjunction with the original publishers.