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    Overview of the vestibular system anatomy and physiology -- The peripheral vestibular system -- The central vestibular system -- Epidemiology of dizziness -- The history of the dizzy patient -- Bedside examination of the vestibular system -- Laboratory examinations of the vestibular system -- Clinical evaluation of hearing -- Infectious diseases -- Benign positional vertigo -- Endolymphatic hydrops (Meniere's syndrome) -- Migraine -- Immune-mediated diseases -- Vascular disorders -- Tumors -- Trauma -- Toxic/metabolic disorders -- Developmental and genetic disorders -- Antiemetic and antivertigo drugs -- Vestibular rehabilitation.
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  • Neurotherapy, sometimes called EEG biofeedback and/or neurobiofeedback involves techniques designed to manipulate brain waves through non-invasive means and are used as treatment for a variety of psychological and medical disorders. The disorders covered include ADHD, mood regulation, addiction, pain, sleep disorders, and traumatic brain injury. This book introduces specific techniques, related equipment and necessary training for the clinical practitioner. Sections focus on treatment for specific disorders and which individual techniques can be used to treat the same disorder and examples.
  • Clinical Neurotoxicology offers accurate, relevant, and comprehensive coverage of a field that has grown tremendously in the last 20 years. You'll get a current symptomatic approach to treating disorders caused by neurotoxic agents, environmental factors, such as heavy metals and pesticides, and more. Apply discussions of cellular and molecular processes and pathology to clinical neurology. Leading authorities and up-and-coming clinical neurotoxicologists present their expertise on wide-ranging, global subjects and debate controversies in the specialty, including Gulf War Syndrome. And, Expert Consult functionality allows you to access the full text of the book online, from any Internet connection.
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  • Clinical Nuclear Cardiology-now in its fourth edition-covers the tremendous clinical growth in this field, focusing on new instrumentation and techniques. Drs. Barry L. Zaret and George A Beller address the latest developments in technology, radiopharmaceuticals, molecular imaging, and perfusion imaging. Thoroughly revised to include 20 new chapters-Digital/Fast SPECT, Imaging in Revascularized Patients, and more-this new edition provides state-of-the-art guidance on key areas and hot topics with stunning visuals. Online access to the fully searchable text at includes highly illustrated case studies that let you see the problem using a variety of imaging modalities. In other words, this is an invaluable resource no clinician or researcher in nuclear cardiology should be without. Features an editorial and contributing team of worldwide leaders in nuclear cardiology to provide you with current and authoritative guidance. Includes a section focusing on acute coronary syndromes to provide you with practical management tools for these conditions. Presents a full-color design that allows color images to be integrated throughout the text.
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    The practical nutritional assessment -- Body composition analysis -- Micronutrient deficiencies -- Clinical consequences of undernutrition -- The malabsorption syndrome -- The Dietary reference intakes: what are they and what do they mean? -- Dietary treatment of gastrointestinal diseases -- Macronutrient digestion, absorption, and metabolism -- Food allergies -- Dietary supplements: herbs and vitamins -- Prebiotics, probiotics, and dietary fiber -- Food and water safety: potential for bioterrorist attack -- Metabolic bone disease in gastrointestinal illness -- Nutrition in the elderly -- Nutrition and alcoholism -- Nutrition and diabetes mellitus -- Nutrition and colorectal cancer -- Nutritional support in inflammatory bowel disease -- Celiac disease -- Nutrition and liver disease -- Nutrition in chronic pancreatitis -- Nutritional support in acute pancreatitis -- Nutrition and gastrointestinal motility in health and disease -- Inborn errors of metabolism for the gastroenterologist -- Nutrition and cystic fibrosis -- Nutrition and gastrointestinal oncology -- The metabolic response to critical illness -- Clinical implications of oxidative stress and antioxidant therapy in gastrointestinal disease -- Perioperative nutritional support -- Dietary management in short bowel syndrome -- Nontransplant surgery for short bowel syndrome -- Intestinal transplantation -- The use of growth factors in short bowel syndrome -- Indications and contraindications to enteral and parenteral nutrition -- Vascular access for the patient receiving parenteral nutrition -- Parenteral nutrition formulas -- Pediatric parenteral nutrition -- Complications of long-term parenteral nutrition -- Complications of enteral nutrition -- Home parenteral nutrition in infants, children, and adults -- Administration routes for enteral nutrition -- Adult enteral nutrition: formulas and supplements -- Pediatric enteral formulas -- Home enteral nutrition -- Refeeding syndrome -- Medical, legal, and ethical aspects of nutritional support -- Medical management of obesity -- Control of food intake -- Surgical management of obesity -- Gastrointestinal complications of bariatric surgery -- Hyperlipidemia: genetic and nutritional considerations for the gastroenterologist -- Management of childhood obesity -- Nutritional support of obese and bariatric patients.
  • The field of clinical nutrition as a whole seeks to consider the nutrition of patients within the healthcare system, paying attention to the interactions between diet, nutrition, and disease. To that end, this book discusses nutrition as both a contributing and managing factor in relation to diseases such as obesity and diabetes. It also presents malnutrition as a contributing factor to such diseases and considers the efficacy of micronutrient supplementation. It ends by looking at some of the recent developments and future trends in the field of clinical nutrition.
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  • This is the first textbook to offer a comprehensive account of ocular prosthetics and the evidence used to underpin and support this field of healthcare. It does so by bringing together information from ophthalmology, prosthetic eye and contact lens literature, and from experts actively engaged in these fields. The book describes the psychological, anatomical and physiological aspects of eye loss as well as surgical procedures for removing the eye, patient evaluation, constructing prosthetic eyes (including prosthetic and surgical techniques for dealing with socket complications), the socket's response to prosthetic eyes, prosthetic eye maintenance and the history of prosthetic eyes. Though primarily intended for prosthetists, ophthalmologists, ophthalmic nurses, optometrists and students in the fields of ocular medicine, maxillofacial medicine and anaplastology, the book also offers a useful resource for other health workers and family members who care for prosthetic eye patients, and for those patients seeking a deeper understanding of the issues affecting them than they can find elsewhere.
  • Written by international authorities in ocular toxicology, including the Founder of The National Registry of Drug-Induced Side Effects and its current Director, this essential resource provides the clinically relevant information you need to effectively diagnose and manage herbal, chemical, and drug-related ocular problems. Comprehensive coverage of all drugs'generic and trade drug names, primary uses, ocular and systemic side effects, and clinical significance make this book - like its best-selling predecessor, Drug-Induced Ocular Side Effects - the ideal reference for quick, on-the-spot consultation. Leaders in the field provide need-to-know information on all aspects of ocular toxicology, all in one concise reference. Data from the National Registry of Drug Induced Ocular Side-Effects (Casey Eye Institute, Portland, OR) and the World Health Organization (Uppsala, Sweden) help you recognize and avoid drug-induced ocular side effects. A highly templated format makes retrieval of essential knowledge quick and easy. A wealth of full-color photographs provide vivid, visual diagnostic guidance. The latest information on approved medications helps you stay up to date and provide state-of-the-art care. Extensive coverage of principles of therapy, ocular drug delivery, methods to evaluate drug-induced visual side effects, and the role of electrophysiology and psychophysics gives you the knowledge you need to manage any challenge in ocular toxicology Authoritative guidance on ocular drugs and their use in pregnancy helps you safely manage the unique needs of these patients. The inclusion of the WHO classification system helps you determine whether a particular side effect is certain, probable, or likely to occur.
  • The second editon of this popular ultrasound book expands the reader's understanding of the clinical applications of ocular ultrasound through a case study approach. With the addition of high-quality video segments of examination techniques not currently available in any other format, this edition appeals to a broader range of practitioners in the field by presenting the subject starting at the basic level and progressing to the advanced. The book is appealing to practitioners involved in ocular ultrasound, including ophthalmic technicians, ophthalmologists, optometrists, radiologists and emergency room physicians who, on occasion, are involved in the practice of ophthalmic ultrasound.
  • 1. Principles of Clinical Epidemiology / Annette C. Moll, Michiel R. de Boer, Lex M. Bouter, and Nakul Singh -- 2. Etiology of Cancer / Brian T. Hill -- 3. Cancer Pathology / Katarina Bartuma, Charlotta All-Ericsson, and Stefan Seregard -- 4. Cancer Angiogenesis / Werner Wackernagel, Bela Anand-Apte, and Arun D. Singh -- 5. Immunology of Ocular Tumors / Martine J. Jager and Inge H.G. Bronkhorst -- 6. Cancer Genetics / J.William Harbour and Daniel L. Chao -- 7. Cancer Staging / Paul T. Finger -- 8. Principles of Cryotherapy / Dan S. Gombos -- 9. Principles of Laser Therapy / Stefan Sacu and Ursula Schmidt-Erfurth -- 10. Principles of Radiation Therapy / Abigail L. Stockham, Ehsan H. Balagamwala, Roger Macklis, Allan Wilkinson, and Arun D. Singh -- 11. Ocular Complications of Radiotherapy / Mitchell Kamrava, James Lamb, and Tara A. McCannel -- 12. Principles and Complications of Chemotherapy / Michael G. Levien, Nicola G. Ghazi, and Arun D. Singh -- 13. Targeted Therapy and Their Ocular Complications / Denis Jusufbegovic, Pierre L. Triozzi, and Arun D. Singh -- 14. Counseling Patients with Cancer / Laura Hope-Stone and Bertil Damato -- 15. Cataract Associated with Intraocular Tumors / Carlos A. Medina, Mary E. Aronow, and Arun D. Singh -- 16. Tumor-Associated Glaucoma / Reena S. Vaswani, Kathryn Bollinger, Annapurna Singh, and Arun D. Singh -- 17. Graft-Versus-Host Disease / Edgar M. Espana, Sejal Shah, and Arun D. Singh -- 18. Uveal Tumors: Diagnostic Techniques: Angiography / Kaan Gunduz, Jessica A. Adefusika, Thomas P. Link, and Jose S. Pulido -- 19. Diagnostic Techniques: Optical Coherence Tomography / Rubens Belfort, Andre Romano, Eduardo Rodrigues, and Arun D. Singh -- 20. Diagnostic Techniques: Autofluorescence / Edoardo Midena, Elisabetta Pilotto, and Raffaele Parrozzani -- 21. Diagnostic Techniques: Ophthalmic Ultrasonography / Brandy Hayden Lorek, Mary E. Aronow, and Arun D. Singh.
  • Written by internationally renowned experts, Clinical Ophthalmic Oncology provides practical guidance and advice on the diagnosis and management of the complete range of ocular cancers. The book supplies all of the state-of-the-art knowledge required in order to identify these cancers early and to treat them as effectively as possible. Using the information provided, readers will be able to: Provide effective patient care using the latest knowledge on all aspects of ophthalmic oncology. Verify diagnostic conclusions based on comparison with numerous full-color clinical photographs from the authors' private collections, histopathologic microphotographs, imaging studies, and crisp illustrations. Locate required information quickly owing to the clinically focused and user-friendly format. In this volume, the examination techniques, classification, and differential diagnosis of eyelid tumors and conjunctival and corneal tumors are carefully explained, and treatment options are considered in detail.
  • Written by internationally renowned experts, Clinical Ophthalmic Oncology provides practical guidance and advice on the diagnosis and management of the complete range of ocular cancers. The book supplies all of the state-of-the-art knowledge required in order to identify these cancers early and to treat them as effectively as possible. Using the information provided, readers will be able to: Provide effective patient care using the latest knowledge on all aspects of ophthalmic oncology. Verify diagnostic conclusions based on comparison with numerous full-color clinical photographs from the authors' private collections, histopathologic microphotographs, imaging studies, and crisp illustrations. Locate required information quickly owing to the clinically focused and user-friendly format. This volume describes the classification, differential diagnosis, and imaging of orbital tumors and discusses the most suitable treatment options for different tumor types.
  • Written by internationally renowned experts, Clinical Ophthalmic Oncology provides practical guidance and advice on the diagnosis and management of the complete range of ocular cancers. The book supplies all of the state-of-the-art knowledge required in order to identify these cancers early and to treat them as effectively as possible. Using the information provided, readers will be able to: Provide effective patient care using the latest knowledge on all aspects of ophthalmic oncology. Verify diagnostic conclusions based on comparison with numerous full-color clinical photographs from the authors' private collections, histopathologic microphotographs, imaging studies, and crisp illustrations Locate required information quickly owing to the clinically focused and user-friendly format. In this volume guidance is provided on diagnosis and therapy for retinal tumors including vitreoretinal lymphoma and paraneoplastic disorders.
  • Evaluation and Diagnosis -- Leukocoria: Differential Diagnosis -- Staging and Grouping -- Epidemiologic Aspects -- International Perspective -- Tumorigenesis -- Retinocytoma or Retinoma -- Genetic Counseling and Testing -- Treatment Options -- Focal Therapy -- Intravenous Chemotherapy -- Intra-Arterial Chemotherapy -- Intravitreal Chemotherapy -- Teletherapy -- Enucleaton -- Histopathologic Features and Risk Factors -- Orbital Retinoblastoma -- Metastatic Disease -- Non Ocular Tumors -- Trilateral Retinoblastoma -- Children's Oncology Group (COG) Trials for Retinoblastoma.
  • "This volume, devoted solely to uveal tumors, explains the various diagnostic and biopsy techniques that may be used and describes the therapeutic options of potential value for different types of tumor."--Publisher's website.
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    1 Ocular examination techniques -- 2 Imaging techniques -- 3 Developmental malformations and anomalies -- 4 Eyelids -- 5 Lacrimal drainage system -- 6 Orbit -- 7 Dry eye disorders -- 8 Conjunctiva -- 9 Cornea -- 10 Corneal and refractive surgery -- 11 Episclera and sclera -- 12 Lens -- 13 Glaucoma -- 14 Uveitis -- 15 Ocular tumours and related conditions -- 16 Retinal vascular disease -- 17 Acquired macular disorders and related conditions -- 18 Fundus dystrophies -- 19 Retinal detachment -- 20 Strabismus -- 21 Neuro-ophthalmology -- 22 Drug-induced disorders -- 23 Trauma -- 24 Systemic diseases.
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    Machine generated contents note: 1.Eyelids -- Introduction -- Benign nodules and cysts -- Benign epidermal tumours -- Benign pigmented lesions -- Benign adnexal tumours -- Miscellaneous benign tumours -- Malignant tumours -- Disorders of lashes -- Allergic disorders -- Bacterial infections -- Viral infections -- Blepharitis -- Ptosis -- Ectropion -- Entropion -- Miscellaneous acquired disorders -- Cosmetic eyelid and periocular surgery -- Congenital malformations -- 2.Lacrimal Drainage System -- Anatomy -- Physiology -- Causes of a watering eye -- Evaluation -- Acquired obstruction -- Congenital obstruction -- Lacnmal surgery -- Chronic canaliculitis -- Dacryocystitis -- 3.Orbit -- Introduction -- Thyroid eye disease -- Infections -- Non-infective inflammatory disease -- Vascular malformations -- Carotid-cavernous fistula -- Cystic lesions -- Tumours -- The anophthalmic socket -- Craniosynostoses -- 4.Dry Eye Disorders -- Definitions -- Physiology -- Classification -- Sjogren syndrome -- Clinical features -- Special investigations -- Treatment -- 5.Conjunctiva -- Introduction -- Bacterial conjunctivitis -- Viral conjunctivitis -- Allergic conjunctivitis -- Conjunctivitis in blistering mucocutaneous disease -- Miscellaneous conjunctivitis -- Degenerations -- 6.Cornea -- Introduction -- Bacterial keratitis -- Fungal keratitis -- Herpes simplex keratitis -- Herpes zoster ophthalmicus -- Interstitial keratitis -- Protozoan keratitis -- Bacterial hypersensitivity-mediated corneal disease -- Rosacea -- Severe peripheral corneal ulceration -- Neurotrophic keratopathy -- Exposure keratopathy -- Miscellaneous keratopathy -- Corneal ectasias -- Corneal dystrophies -- Corneal degenerations -- Metabolic keratopathies -- Contact lenses -- Congenital anomalies of the cornea and globe -- 7.Corneal and Refractive Surgery -- Keratoplasty -- Keratoprostheses -- Refractive procedures -- 8.Episclera and Sclera -- Anatomy -- Episcleritis -- Immune-mediated scleritis -- Infectious scleritis -- Scleral discoloration -- Blue sclera -- Miscellaneous conditions -- 9.Lens -- Acquired cataract -- Management of age-related cataract -- Congenital cataract -- Ectopia lentis -- Abnormalities of shape -- 10.Glaucoma -- Introduction -- Tonometry -- Gonioscopy -- Evaluation of the optic nerve head -- Imaging in glaucoma -- Perimetry -- Ocular hypertension -- Primary open-angle glaucoma -- Normal-pressure glaucoma -- Primary angle-closure glaucoma -- Classification of secondary glaucoma -- Pseudoexfoliation -- Pigment dispersion -- Neovascular glaucoma -- Inflammatory glaucoma -- Lens-related glaucoma -- Traumatic glaucoma -- Iridocorneal endothelial syndrome -- Glaucoma in intraocular tumours -- Glaucoma in epithelial ingrowth -- Glaucoma in iridoschisis -- Primary congenital glaucoma -- Iridocorneal dysgenesis -- Glaucoma in phacomatoses -- Glaucoma medications -- Laser therapy -- Trabeculectomy -- Non-penetrating surgery -- Antimetabolites in filtration surgery -- Drainage shunts -- 11.Uveitis -- Introduction -- Clinical features -- Special investigations -- Principles of treatment -- Intermediate uveitis -- Uveitis in spondyloarthropathies -- Uveitis in juvenile arthritis -- Uveitis in bowel disease -- Uveitis in renal disease -- Sarcoidosis -- Behcet syndrome -- Toxoplasmosis -- Toxocariasis -- Miscellaneous parasitic uveitis -- Uveitis in acquired immunodeficiency syndrome -- Miscellaneous viral uveitis -- Fungal uveitis -- Bacterial uveitis -- White dot syndromes -- Primary stromal choroiditis -- Miscellaneous anterior uveitis -- Miscellaneous posterior uveitis -- 12.Ocular Tumours -- Benign epibulbar tumours -- Malignant and premalignant epibulbar tumours -- Iris tumours -- Iris cysts -- Ciliary body tumours -- Tumours of the choroid -- Neural retinal tumours -- Vascular retinal tumours -- Primary intraocular lymphoma -- Tumours of the retinal pigment epithelium -- Paraneoplastic syndromes -- 13.Retinal Vascular Disease -- Retinal circulation -- Diabetic retinopathy -- Retinal venous occlusive disease -- Retinal arterial occlusive disease -- Ocular ischaemic syndrome -- Hypertensive disease -- Sickle-cell retinopathy -- Retinopathy of prematurity -- Retinal artery macroaneurysm -- Primary retinal telangiectasia -- Eales disease -- Radiation retinopathy -- Purtscher retinopathy -- Benign idiopathic haemorrhagic retinopathy -- Valsalva retinopathy -- Lipaemia retinalis -- Retinopathy in blood disorders -- Congenital vascuiar anomalies -- 14.Acquired Macular Disorders -- Introduction -- Clinical evaluation of macular disease -- Fundus fluorescein angiography -- Indocyanine green angiography -- Optical coherence tomography -- Age-related macular degeneration -- Polypoidal choroidal vasculopathy -- Age-related macular hole -- Macular microhole -- Central serous chorioretinopathy -- Cystoid macular oedema -- Epimacular membrane -- Degenerative myopia -- Angioid streaks -- Choroidal folds -- Hypotony maculopathy -- Vitreomacular traction syndrome -- Idiopathic choroidal neovascularization -- Solar retinopathy -- 15.Hereditary Fundus Dystrophies -- Introduction -- Investigations -- Generalized photoreceptor dystrophies -- Macular dystrophies -- Generalized choroidal dystrophies -- Vitreoretinal dystrophies -- Albinism -- Cherry-red spot at macula -- 16.Retinal Detachment -- Introduction -- Rhegmatogenous retinal detachment -- Tractional retinal detachment -- Exudative retinal detachment -- Pars plana vitrectomy -- 17.Vitreous Opacities -- Introduction -- Muscae volitantes -- Vitreous haemorrhage -- Asteroid hyalosis (Benson disease) -- Synchisis scintillans (choiesterolosis bulbi) -- Amyloidosis -- Vitreous cyst -- 18.Strabismus -- Introduction -- Amblyopia -- Clinical evaluation -- Heterophoria -- Vergence abnormalities -- Esotropia -- Exotropia -- Special syndromes -- Alphabet patterns -- Surgery -- 19.Neuro-ophthalmology -- Neuroimaging -- Optic nerve -- Pupillary reactions -- Chiasm -- Retrochiasmal pathways -- Ocular motor nerves -- Supranuclear disorders of ocular motility -- Nystagmus -- Carotid stenosis -- Intracranial aneurysms -- Ocular myopathies -- Neurofibromatosis -- Migraine -- Facial spasm -- 20.Ocular Side-effects of Systemic Medication -- Cornea -- Lens -- Uveitis -- Retina -- Optic nerve -- 21.Trauma -- Eyelid trauma -- Orbital fractures -- Trauma to the globe -- Chemical injuries.
  • Ocular Examination Techniques -- Imaging Techniques -- Developmental Malformations and Anomalies -- Eyelids -- Lacrimal Drainage System -- Orbit -- Dry Eye -- Conjunctiva -- Cornea -- Corneal and Refractive Surgery -- Episclera and Sclera -- Lens -- Glaucoma -- Uveitis -- Ocular Tumours and Related Conditions -- Retinal Vascular Disease -- Acquired Macular Disorders -- Fundus Dystrophies -- Retinal Detachment -- Strabismus -- Neuro-ophthalmology -- Drug-induced Disorders -- Trauma -- Systemic Disease.
  • "In Clinical Orthopaedic Rehabilitation: An Evidence-Based Approach, Dr. S. Brent Brotzman and Robert C. Manske help you apply the most effective, evidence-based protocols for maximizing return to function following common sports injuries and post-surgical conditions. A well-respected, comprehensive source for evaluating, treating, and rehabilitating orthopaedic patients, the 3rd Edition guides you on the prevention of running injuries, the latest perturbation techniques, and the ACL rehabilitation procedures and functional tests you need to help get your patients back in the game or the office. You'll also find a brand-new spine rehabilitation section."--pub. desc.
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    Classifications and definitions -- Examination sequence for history and tests and measures -- Temporomandibular joint -- Cervical spine -- Thoracic spine -- Lumbar spine -- Pelvis -- Shoulder joint complex -- Elbow and forearm -- Wrist and hand -- Functional assessment of the upper extremity -- Hip joint -- Knee -- Foot and ankle -- Functional assessment of the lower extremity -- Posture -- Gait -- Other gait sequences -- Upper-extremity and lower-extremity neurodynamics.
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    v. 1. Cardiovascular-renal problems.
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    The cardiovascular system -- The pulmonary system -- The renal system -- The gastrointestinal system -- The endocrine system -- The hematologic system -- The nervous system -- Rheumatology -- Male and female reproductive systems -- Cases.
  • This book provides a carefully selected compilation of challenging cases representative of the situations and pathologies likely to be encountered when performing cardiovascular imaging using CT. The conditions covered include coronary artery disease, anomalous coronary arteries, congenital heart disease, coronary artery bypass grafts, infectious diseases, structural heart disease, tumors, and aortic pathology. The book also provides brief insight into use of Cardiac CT geared towards the pre-procedural use in patients undergoing atrial fibrillation ablation, thoracic endovascular aortic repair, or transcatheter aortic valve replacement. In addition, scanning techniques for some of the more difficult cases that a cardiac imager may encounter in practice are reviewed. All images are high-resolution reproductions, and subsequent cardiac catheterization images are included for cases in which obstructive coronary artery disease was revealed. Clinical Pearls in Diagnostic Cardiac Computed Tomographic Angiography is specifically designed to meet the needs of residents, fellows, and physicians who have an interest in cardiovascular CT.
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    Structure and development of the kidney -- Water and electrolyte handling by the kidney -- Disorders of mineral metabolism -- Epidemiology of renal disease in children -- Clinical assessment of renal function -- Diagnostic imaging of the urinary tract -- Radionuclide imaging -- Renal biopsy -- Hematuria and proteinuria -- Acute glomerulonephritis and rapidly progressive glomerulonephritis -- Nephrotic syndrome -- Inherited nephropathies -- Immunoglobulin A nephropathy and Henoch-Schönlein purpura nephritis -- Tubulointerstitial nephritis -- Hemolytic uremic syndrome -- Kidney in systemic lupus erythematosus and vasculitis -- Cystic kidney diseases -- Kidney in viral infections -- Sickle cell nephropathy -- Renal tubular acidosis -- Disorders of tubular transport -- Chronic kidney disease -- Renal osteodystrophy -- Acute renal failure -- Hemodialysis -- Peritoneal dialysis -- Continuous renal replacement therapy - Renal transplantation -- Nutrition in renal disease -- Hypertension: epidemiology and evaluation -- Mangement of hypertension in children and adolescents -- Syndromic renal disorders and malformations -- Obstructive uropathy -- Voiding disorders -- Urolithiasis -- Urinary tract infection -- Pediatric renal tumors.
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    Neonatal neurologic and neurosurgical disorders -- Chronic static encephalopathies -- Chronic progressive encephalopathies: inborn errors of metabolism -- Acute encephalopathy -- Traumatic brain injury -- Cerebrovascular disorders in children -- Neurocutaneous disorders -- Febrile seizures -- Epilepsy -- Headaches -- Movement disorders -- Ataxias -- Neuromuscular disorders -- Sleep disorders of childhood and adolescence -- Brain tumors -- Hydrocephalus -- Skull deformities: plagiocephaly and craniosynostosis -- The Chiari malformation and syringomyelia -- Spinal dysraphism and neurogenic bladder dysfunction.
  • Clinical PET and PET/CT, 2nd Edition presents a valuable overview of the basic principles and clinical applications of PET and PET/CT. Emphasis is placed on the familiarization of normal distribution, artifacts, and common imaging agents such as FDG in conjunction with CT, MRI, and US to establish the clinical effectiveness of PET and PET/CT. Practical information about updated PET and PET/CT scanners, imaging processing, correlation, and quantification of PET and PET/CT measurements is also presented. This book is divided into two sections, the first half dealing with the basic principles of PET and PET/CT for instrumentation, fusion, radiopharmaceuticals, radiosynthesis, safety, and cost analysis. The second part of this volume presents chapters on the clinical techniques and applications of PET and PET/CT for common oncologic, cardiologic, and neurologic diseases. Numerous full color images provide comprehensive coverage on essential clinical PET and PET/CT studies.
  • Principles, design, and operation of multi-slice CT -- PET imaging basics -- Design and operation of combined PET-CT scanners -- CT-based attenuation correction for PET -- Technical artifacts in PET-CT imaging -- Quantitation of PET data in clinical practice -- Patient preparation and management -- Radiation protection of technologists and ancillary personnel -- Application of CT contrast agents in PET-CT imaging -- Performance, interpretation, and reporting of PET-CT scans for body oncology imaging -- Pediatric management and preparation in PET-CT -- PET-CT in radiation treatment planning -- Probability and the principles of diagnostic certainty in medical imaging -- Principles of medical imaging in the diagnosis and staging of the cancer patient -- Principles of PET in cancer treatment for the assessment of chemotherapy and radiotherapy response and for radiotherapy treatment planning -- PET-CT imaging of lung cancer -- PET-CT of esophageal cancer -- PET-CT of head and neck cancers -- PET-CT of thyroid cancer -- PET-CT in breast cancer -- PET-CT in colorectal carcinoma -- PET-CT imaging of lymphoma -- PET-CT imaging in multiple myeloma, solitary plasmacytoma, and related plasma cell dyscrasias -- PET-CT of melanoma -- PET-CT of ovarian cancer -- PET-CT of cervical and uterine cancer -- PET-CT of testicular malignancies -- PET-CT in pediatric malignancies -- PET-CT of renal cell carcinoma -- PET-CT in soft tissue malignancies -- PET-CT of pancreatic cancer -- PET-CT of bone metastases.
  • This comprehensive review provides a systematic, unbiased analysis, critique and summary of the available literature and generates novel clinical decision-making algorithms which can aid clinicians and scientists in practice management and research development. Potential mechanisms for the identified drug interactions are deduced from available preclinical and in vitro data which are interpreted in the context of the in vivo findings. Current limitations and gaps in the literature are summarized, and potential future research directions / experimentations are also suggested. In addition to the main objective to review the available clinical pharmacokinetic and pharmacodynamic drug interactions associated with WHO-recommended antimalarial drugs on the market today (i.e. chloroquine, amodiaquine, sulfadoxine, pyrimethamine, mefloquine, artemisinin, artemether, artesunate, dihydroartemisinin, artemotil, lumefantrine, primaquine, atovaquone, proguanil, piperaquine and quinine), this book also provides succinct chapter summaries on the epidemiology of malaria infection, diagnosis and therapeutics, in vivo pharmacology and chemistry, preclinical pharmacology, in vitro pharmacodynamics, in vitro reaction phenotyping, and in vitro drug-drug interaction data associated with the identified antimalarial drugs.
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    This edition has been retitled Clinical Pharmacokinetics and Pharmacodynamics: Concepts and Applications to reflect the increasing body of knowledge linking the two concepts that explain the relationship between drug administration and drug response and also reflects the expansion in our understanding at the molecular and mechanistic levels of all the processes controlling the pharmacokinetics of drugs.
  • A thorough knowledge of pharmacological and therapeutic principles is vital if drugs are to be used safely and effectively for increasingly informed patients. Those who clearly understand how drugs get into the body, how they produce their effects, what happens to them in the body, and how evidence of their therapeutic effect is assessed, will choose drugs more skilfully, and use them more safely and successfully than those who do not. Now in a fully revised 11th edition, Clinical Pharmacology is essential reading for undergraduate medical students, junior doctors and anyone concerned with ev.
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    Chapter 1. Cell function -- Chapter 2. Blood pressure -- Chapter 3. Electrolytes and acid-base metabolism -- Chapter 4. Evaluation of renal function -- Chapter 5. Evaluation of cardiac function -- Chapter 6. The respiratory system -- Chapter 7. Blood cells and blood coagulation -- Chapter 8. The immune system -- Chapter 9. Neurophysiology -- Chapter 10. The digestive system -- Chapter 11. The endocrine system.
  • The Clinical practice handbook for safe abortion care is intended to facilitate the practical application of the clinical recommendations from the second edition of Safe abortion: technical and policy guidance for health systems (World Health Organization [WHO] 2012). While legal, regulatory, policy and service-delivery contexts may vary from country to country, the recommendations and best practices described in both of these documents aim to enable evidence-based decision-making with respect to safe abortion care.
  • This text prepares its users to deliver expert care in this most challenging nursing specialty. It addresses neuroanatomy, assessment, diagnostic evaluation and management of the complete range of neurological disorders for which nurses provide patient care, including trauma, stoke, tumors, seizures, headache, aneurysms, infections, degenerative disorders and features new chapters on neurological critical care and peripheral neuropathies. The new edition has been thoroughly revised to reflect standards of care based on evidence-based practice. It now includes separate pathophysiology sections in each chapter, new resource guides, such as internet sites and professional and patient information sources, key points summaries, evidence-based boxes, and nursing research features.
  • The hospital team -- Surgery and surgical teams -- Anesthesia -- Selected hospital medical units -- General departments -- Index of procedures -- Introduction -- Abdominal wall defect repair -- Ambulatory ECG monitoring -- Amniocentesis -- Anesthesia, general -- Anesthesia, local -- Angiography -- Angioplasty -- Aortic aneurysm graft -- Appendectomy -- Arthroscopy of knee -- Bariatric surgery -- Biopsy, bone marrow -- Biopsy, breast -- Biopsy, liver -- Biopsy, lung -- Biopsy, prostate -- Bladder suspension -- Blood pressure measurement -- Blood trasfusion -- Breast augmentation surgery -- Breast reduction surgery -- Caesarean section -- Cardiac output measurement -- Carotid endarterectomy -- Cataract removal -- Chemotherapy -- Cholecystectomy -- Circumcision -- Colonoscopy -- Colostomy -- Cornea transplant -- Coronary artery bypass graft -- Craniotomy -- Cystectomy -- Cystoscopy -- Defibrillation -- Dilatation and curettage -- Discectomy -- Electrocardiogram -- Electroconvulsive therapy -- Electroencephalogram -- Episiotomy -- Fetal monitoring -- Gastrectomy -- Heart transplant -- Heart valve surgery -- Hemodialysis -- Hemorrhoidectomy -- Hip arthroplasty -- Hysterectomy -- Hysteroscopy -- Ileostomy -- In vitro fertilization -- Incisional hernia surgery -- Inguinal hernia repair -- INTACS -- Kidney transplant -- Knee arthroplasty -- Labor and delivery -- Laminectomy -- Laryngectomy -- LASIK -- Lithotripsy -- Liver transplant -- Mastectomy, lumpectomy -- Mastectomy, radical -- Mastectomy, simple -- Myringotomy -- Pacemaker application -- Patent ductus arteriosus repair -- Peritoneal dialysis -- Prostate surgery -- Pulse oximetry -- Radiation therapy -- Septoplasty -- Shunt for hydrocephalus -- Splenectomy -- Stress test -- Thyroidectomy -- Tonsillectomy -- Total parenteral nutrition -- Tracheostomy -- Tubal ligation -- Uterine ablation -- Vasectomy.
  • Evidence-based eye examinations -- Communication skills -- Assessment of visual function -- Refraction and prescribing -- Contact lens assessment -- Assessment of Binocular Vision and Accommodation -- Ocular health assessment -- Variations in appearance of the normal eye -- Physical examination procedures.
  • Overview and introduction to clinical proteomics / Young-Ki Paik ... [et al.] -- Specimen collection and handling : standardization of blood sample collection / Harald Tammen -- Tissue sample collection for proteomics analysis / Jose I. Diaz, Lisa H. Cazares, and O. John Semmes -- Protein profiling of human plasma samples by two-dimensional electrophesis / Sang Yun Cho ... [et al.] -- Analysis of laser capture microdissected cells by 2-dimensional gel electrophoresis / Daohai Zhang and Evelyn Siew-Chuan Koay -- Optimizing the difference gel electrophesis (DIGE) technology / David B. Friedman and Kathryn S. Lilley -- MALDI/SELDI protein profiling of serum for the identification of cancer biomarkers / Lisa H. Cazares ... [et al.] -- Urine sample preparation and protein profiling by two-dimensional electrophoresis and matrix-assisted laser desorption ionization time of flight mass spectroscopy / Panagiotis G. Zerefos and Antonia Vlahou -- Combining laser capture microdissection and proteomics techniques / Dana Mustafa, Johan M. Kros, and Theo Luider -- Comparison of protein expression by isotope-coded affinity tag labeling / Zhen Xiao and Timothy D. Veenstra -- Analysis of microdissected cells by two-dimensional LC-MS approaches / Chen Li ... [et al.] -- Label-free LC-MS method for the identification of biomarkers / Richard E. Higgs ... [et al.] -- Analysis of the extracellular matrix and secreted vesicle proteomes by mass spectrometry / Zhen Xiao ... [et al.] -- Miniaturized parallelized sandwich immunoassays / Hsin-Yun Hsu, Silke Wittemann, and Thomas O. Joos -- Dissecting cancer serum protein profiles using antibody arrays / Marta Sanchez-Carbayo -- 2D-PAGE maps analysis / Emilio Marengo, Elisa Robotti, and Marco Bobba -- Finding the significant markers : statistical analysis of proteomic data / Sebastien Christian Carpentier ... [et al.] -- Web-based tools for protein classification / Costas D. Paliakasis, Ioannis Michalopoulos, and Sophia Kossida -- Open-source platform for the analysis of liquid chromatography-mass spectrometry (LC-MS) data / Matthew Fitzgibbon ... [et al.] -- Pattern recognition approaches for classifying proteomic mass spectra of biofluids / Ray L. Somorjai.
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  • Ch. 1. Clinical psychology for cardiac disease / E. Molinari, L. Bellardita, A. Compare -- Pt. I. Psychological risk factors for cardiac disease. Ch. 2. Psychological risk factors for cardiac disease and pathophysiological mechanisms: an overview / A. Compare, L. Gondoni, E. Molinari -- Ch. 3. Psychophysiology of heart disease / G. Parati, M. Valentini, G. Mancia -- Ch. 4. Mental stress ischemia: characteristics, pathophysiology, prognosis and treatment / M.M. Burg -- Ch. 5. Depression and CHD: prevalence, prognosis, pathophysiology and treatment / K. Maier, D. Chatkoff, M.M. Burg -- Ch. 6. Prevalence of depression in chronic heart failure / E.P. Havranek -- Ch. 7. Depression in coronary artery disease: assessment and treatment / W.J. Kop, D.N. Ader -- Ch. 8. Anxiety and heart disease / D.K. Moser, M.J. De Jong -- Ch. 9. Anxiety, depressive symptoms and heart transplantation / S. Zipfel et al. -- Ch. 10. Psychological factors in hypertension development and treatment / T. Rutledge -- Ch. 11. Type A, Type D, anger-prone behavior and risk of relapse in CHD patients / A. Compare, G.M. Manzoni, E. Molinari -- Ch. 12. Defensive hostility and cardiovascular disease: theoretical and empirical bases for an interpersonal approach-avoidance conflict perspective / R.S. Jorgensen, R. Thibodeau -- Ch. 13. In sickness and in health: interpersonal risk and resilience in cardiovascular disease / J.M. Ruiz et al. -- Ch. 14. Psychological stress in women: the Stockholm Female Coronary Risk Study / K. Orth-Gomèr -- Ch. 15. Application of neural networks and other artificial adaptive systems in prediction and data mining of risk psychological profile for CHD / E. Grossi, A. Compare -- Ch. 16. Person measurement and rehabilitation outcome: the new perspective of Rasch analysis / L. Tesio -- Interlude. The "heart" of cardiology: an imaginary conversation with Bernard Lown / E. Molinari -- Pt. II. Psychological treatment in cardiac rehabilitation. Ch. 17. The art of listening to cardiac patient and his family: the meanings of suffering along temporal dimension / A. Compare, M. Simioni -- Ch. 18. Interpersonal psychotherapy for depression in patients with coronary heart disease / D. Koszycki -- Ch. 19. Hanging onto a heartbeat: emotionally focused therapy for couples dealing with the trauma of coronary heart disease / H.B. MacIntosh, S.M. Johnson, A. Lee -- Ch. 20. Type A behavior pattern and its treatment / A.T. Möller -- Ch. 21. Relaxation techniques and hypnosis in the treatment of CHD patients / L. Bellardita, M. Cigada, E. Molinari -- Ch. 22. Cardiological and psychological mobile care through telematic technologies for heart failure patients: ICAROS Project / A. Compare et al. -- Ch. 23. Functioning and disability in patients with cardiovascular disease within the ICF classification framework: proposals for using ICF to classify functioning and disability in patients with cardiovascular disease / M. Leonardi, A. Raggi -- Ch. 24. Coherence-building techniques and heart rhythm coherence feedback: new tools for stress reduction, disease prevention and rehabilitation / R. McCraty, D. Tomasino.
  • Perfect for radiation oncology physicians and residents needing a multidisciplinary, treatment-focused resource, this updated edition continues to provide the latest knowledge in this consistently growing field. Not only will you broaden your understanding of the basic biology of disease processes, you'll also access updated treatment algorithms, information on techniques, and state-of-the-art modalities. The consistent and concise format provides just the right amount of information, making Clinical Radiation Oncology a welcome resource for use by the entire radiation oncology team. Content.
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    Overview and principles of diagnostic imaging -- Radiographic contrast agents -- Interventional and invasive radiology -- Pulmonary imaging -- Cardiac imaging -- Breast imaging -- Abdominal radiographs -- Gastrointestinal imaging -- Urinary tract imaging -- Urinary tract imaging -- Obstetric and gynecologic imaging -- Musculoskeletal imaging -- Cranial imaging -- Vertebral imaging.
  • Mechanisms of functional recovery after stroke / Ko, S.-B.; Yoon, B.-W -- Diagnostic approach to functional recovery : functional magnetic resonance imaging in stroke / Havsteen, I. ... [et al.] -- Diagnostic approach to functional recovery : diffusion-weighted imaging and tractography / Raffin, E.; Dyrby, T -- Compensatory development of the contralateral pyramidal tract after experimental cerebral ischemia / Takatsuru, Y.; Nakamura, K.; Nabekura, J -- Compensatory contribution of the contralateral pyramidal tract after stroke / Otsuka, N. ... [et al.] -- Regeneration of neuronal cells following cerebral injury / Dailey, T. ... [et al.] -- Translational challenge for cell therapy following stroke / Kuroda, S.; Houkin, K. -- Experimental and clinical challenge for neuroregeneration following stroke / Kasahara, Y.; Ihara, M.; Taguchi, M. -- Therapeutic drug approach to stimulate clinical recovery after brain injury / Krieger, D.W. -- Rehabilitation and plasticity / Luft, A.R. -- A brain-computer interface to support functional recovery / Kjaer, T.W.; Sorensen, H.B. -- Novel methods to study aphasia recovery after stroke / Hartwigsen, G.; Siebner, H.R. -- Role of repetitive transcranial magnetic stimulation in stroke rehabilitation / Pinter, M.M.; Brainin, M. -- Influence of therapeutic hypothermia on regeneration after cerebral ischemia / Yenari, M.A.; Han, H.S. -- Reasonable suppression of body weight with high-voltage electric potential therapy in humans: a translational study to increase brain-derived neurotrophic factor levels in the brain / Hiroji, Y. ... [et al.] -- Prevention of post-stroke disuse muscle atrophy with a free radical scavenger / Naritomi, H.
  • Why we need clinical research -- Historical perspectives of clinical research -- Evidence-based surgery defined -- Myths and misconceptions about evidence-based medicine -- Becoming an evidence-based surgeon -- Principles of clinical research -- Various research design classifications -- Hierarchy of research studies: from case series to meta-analyses -- Randomized and nonrandomized studies -- Understanding research study design -- Clinical case series -- Case-control study -- Prospective cohort study -- Randomized trial -- Meta-analysis -- Economic analysis -- Diagnostic study -- Reliability study -- Understanding outcomes measurement -- Classification of outcomes -- What makes an outcome measure useful -- Common generic outcome scales for surgeons -- Common disease-specific outcome scales for surgeons -- Understanding treatment effects -- Common ways to present treatment effects -- Confidence interval defined -- P value defined -- Errors in hypothesis testing -- Clinical versus statistical significance -- Practice of clinical research -- Planning a research study -- Requirements of a clinical research proposal -- Identification of a good research question -- How to conduct a comprehensive literature search -- Guide to planning a randomized trial -- Guide to planning a nonrandomized study -- Study sample size -- How to budget for a research study -- Research ethics, review boards, and consent forms -- Regulatory issues in the evaluation of a new device or drug -- Strategies in research funding -- Conducting a research study -- Roles of the research team -- Role of a central methods center -- Role of a data monitoring committee -- Need for separate adjudication of outcomes -- Data management -- Study case report forms -- Study manual of operations -- Review of basic statistical principles -- Statistical means and proportions -- Regression analysis -- Analysis of variance -- Correlation defined.
  • "This book provides foundational coverage of key areas, concepts, constructs, and approaches of medical informatics as it applies to clinical research activities, in both current settings and in light of emerging policies. The field of clinical research is fully characterized (in terms of study design and overarching business processes), and there is emphasis on information management aspects and informatics implications (including needed activities) within various clinical research environments. The purpose of the book is to provide an overview of clinical research (types), activities, and areas where informatics and IT could fit into various activities and business practices. This book introduces and applies informatics concepts only as they have particular relevance to clinical research settings"--Provided by publisher.
  • Introduction to research -- Site administration -- Managing financial processes -- Managing regulatory activities and documents -- Managing clinical trial activities -- Managing data and research records -- Conclusions and final remarks.
  • Planning the research / Eugene Blackstone -- Ethical issues in clinical research / David F. Penson -- Budget development and staffing / Judith Fine and Peter C. Albertsen -- Non randomized interventional study designs (quasi-experimental designs) / David Axelrod, Rodney Hayward -- Randomized clinical trials of surgical procedures / Michael P. Porter -- Use of observational databases (registries) in research / Deborah P. Lubeck -- Risk adjustment / William G. Henderson and Shukri F. Khuri -- Basic statistical methods / David Etzioni, Nadia Howlader, and Ruth Etzioni -- Survival analyses / Rodney L. Dunn and John T. Wei -- Assessing the performance and validity of diagnostic tests and screening programs / David C. Miller, Rodney L. Dunn, and John T. Wei -- Secondary data analyses / Andrew Rosenberg, MaryLou VH Greenfield, and Justin B. Dimick -- Traditional outcome measures / Aruna V. Sarma, and Julie C. McLaughlin -- Health-related quality of life / Mark Litwin -- Measuring patient satisfaction / Arvin Koruthu George and Martin G. Sanda -- Quality of care / Jessica B. O'Connell and Clifford Y. Ko -- Cost-effectiveness analyses / Lynn Stothers -- Qualitative research / Donna L. Berry, Sally L. Maliski, and William J. Ellis -- Systematic reviews and meta-analyses / Timothy J. Wilt and Howard A. Fink.
  • This book provides insights into how to be a productive clinical researcher via real-life case examples of successful clinical research -- and also clinical research gone awry. Through these examples of success and failure, the book develops a blueprint for building a career in clinical research. Future medical practice depends on the quality of the clinical trials to which drugs, devices, and treatment procedures are subjected today. However, clinical trials are not easy to do, and many physicians and health care providers who attempt clinical research struggle in this endeavor, primarily because of lack of instruction. Clinical Research aims to fill the gap between training and research through case studies of a long-time clinical researcher's rich and varied experiences.
  • This book provides practical guidance to help you more effectively diagnose and manage the full range of pulmonary disorders, including those seen in today's most challenging patient populations. Take a practical approach to the diagnosis and management of patients with respiratory disorders using this ideal source for reference in clinical practice.
  • Oral and maxillofacial radiology -- Pharmacology -- Anesthesia -- Oral and maxillofacial infections -- Dentoaveolar surgery -- Dental implant surgery -- Head and neck pathology -- Craniomaxillofacial trauma surgery -- Orthognathic surgery -- Temporomandibular joint disorders -- Oral cancer -- Reconstructive oral and maxillofacial surgery -- Facial cosmetic surgery -- Syndromes of the head and neck -- Medical conditions.
  • Care of the vascular trauma patient is a unique undertaking that requires a cohesive, multidisciplinary approach from all the surgical subspecialties to be successful. This is the first textbook of its kind to bring together all prominent management strategies from each of the surgical subspecialties, creating a unified voice on the management of the vascular trauma patient.? The purpose of the book is to serve as a practical surgical reference for the diagnosis and management of traumatic vascular injuries. Management of common vascular injuries is examined from a general, trauma, vascular, orthopaedic, plastics, cardiothoracic, and neurosurgical perspective by respected experts from each of these fields. Each section has been edited by specialists in the other relevant disciplines to ensure that every chapter represents an evidence-based assessment of all of the surgical subspecialties. Some essential topics include ideal choices of incision, endovascular versus open surgery, and the order in which to repair complex orthopedic and vascular injuries. Supplementing the clear and concise text are dozens of surgical photographs, illustrations, tables, and charts that assist in conveying complex concepts in vascular trauma management. Insights from the multidisciplinary panel of authors and editors help to simplify complex decision-making and streamline the overall care for critically ill patients. The Clinical Review of Vascular Trauma will be essential reading for any healthcare professional involved in care of the trauma patient.
  • This book covers interesting and yet often challenging cases among adult patients in a unique Question-Answer format. Simulating the bed-side case discussions during the ward rounds, one question logically leads to another question thereby generating curiosity and promoting evidence-based medicine. Taking the readers through the entire spectrum starting from etiology and pathophysiology to clinical presentation to management principles, each question addresses one key aspect of the disorder. Described in a very simple and lucid narrative, this book ensures sound conceptual understanding while covering each topic comprehensively. This volume covers important topics such as acromegaly, Cushing syndrome, osteoporosis, hypercalcemia, pheochromocytoma, hyperaldosteronism, thyroid disorders, and diabetes in adult patients. These cases are not only seen by endocrinologists, but are also managed by internists, orthopedic surgeons, obstetricians and gynecologists. Less common disorders such as adrenal disorders and androgen excess have also been covered.
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  • Introduction : the practice of clinical pharmacy -- Communication skills for the pharmacist -- Taking medication histories -- Physical assessment skills -- Review of laboratory and diagnostic tests -- The patient case presentation -- Therapeutics planning -- Monitoring drug therapies -- Researching and providing drug information -- Ethics in pharmacy and health care.
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    Insomnia: causes and treatments / Sidney D. Nau and Kenneth L. Lichstein -- Narcolepsy and idiopathic hypersomnia / Richard B. Berry and Robin L. Gilmore -- Restless legs syndrome (RLS) and periodic limb movement disorder (PLMD) / Richard P. Allen -- Parasomnias / Juan G. Ochoa and Mario Pulido -- Circadian rhythm sleep disorders / Phyllis C. Zee and Kathryn Reid -- Obstructive sleep apnea hypopnea syndromes: definitions, epidemiology, diagnosis, and consequences / Richard B. Berry and Runi Foster -- Obstructive sleep apnea: treatment overview and controversies / Nancy A. Collop -- Positive airway pressure treatment for sleep apnea / Richard B. Berry and Mark H. Sanders -- Obstructive sleep apnea: surgical treatment / Kasey K. Li -- Obstructive sleep apnea: treatment with oral appliance / Wolfgang W. Schmidt-Nowara -- Central sleep apnea / Atul Malhotra, Richard B. Berry, and David P. White -- Diencephalic and brainstem sleep disorders / David Surhbier -- Introduction to sleep and sleep monitoring: the basics / Richard B. Berry, James Geyer, and Paul Carney -- -- Normal human sleep / Charles J. Bae and Nancy Foldvary-Schaefer -- The neurobiology of sleep / Wendy M. Norman and Linda F. Hayward -- Breathing during sleep: ventilation and the upper airway / James A. Rowley and M. Safwan Badr -- Sleep and normal human physiology / James Geyer and Stephenie Dillard -- Chronobiology and circadian rhythms / Arthur Andrews and Selim Benbadis -- Ontogeny of sleep / Paul R. Carney, Danielle Becker, and Susan Bongiolatti -- -- Sleepiness / Barbara Phillips -- Evaluating sleeplessness / Edward J. Stepanski -- Nocturnal events / Troy Payne -- Pediatric and adolescent presentations / Danielle A. Becker and Paul R. Carney -- Sleep problems of the elderly / Stephan Eisenschenk -- Psychiatric disorders and sleep / Andrew D. Krystal, Mugdha Thakur, and W. Vaughn Mccall -- Sleep disorders, dementia, and related degenerative disorders / Bradley F. Boeve and Michael H. Silber -- Sleep and epilepsy / Bradley V. Vaughn and O'Neill F. D'Cruz -- Sleep and cardiovascular diseases / Lyle J. Olson, Anna Svatikova, and Virend K. Somers -- Sleep and pulmonary diseases / W. McDowell Anderson, Arthur Andrews, and David G. Davila -- Sleep and internal medicine / Susan M. Harding and Jeffrey W. Hawkins.
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    Abnormal fetal heart / Joyce Cordier -- Carotid artery disease / Rebecca Schilling -- Intracranial vascular problems / Gail Sandager-Hadley -- Pain and swelling in the limbs / Gail Sandager-Hadley, Roger C. Sanders -- Arterial problems in the limbs / Gail Sandager-Hadley -- Shoulder problems / Tom Winter -- Common ankle and foot problems / Jag Dhanju -- Ultrasound-guided interventional procedures / Tom Winter -- Nursing procedures / Deroshia Stanley -- Work-related musculoskeletal disorders in sonography / Carolyn Coffin, Susan Murphy -- Artifacts / Roger Gent -- Equipment care and quality control / Roger Gent -- Photography / Roger C. Sanders, Tom Winter -- Preliminary reports / Roger C. Sanders -- Malpractice and ultrasound / Roger C. Sanders -- Accreditation chapter / Carol Mitchell. Basic physics / Roger C. Sanders, Mike Ledwidge -- Instrumentation / Barbara Del Prince, Roger C. Sanders -- Knobology / Mimi Maggio Sayler, Barbara Del Prince -- Doppler and color flow principles / Mike Ledwidge, Tom Winter, Barbara Del Prince -- Basic principles / Nancy Smith Miner -- Sonographic abdominal anatomy / Julia A. Drose -- Epigastric pain (upper abdominal pain): pancreatitis? / Julia A. Drose -- Right upper quadrant mass: possible metastases to liver / Lisa Parsons, Tom Winter -- Right upper quadrant pain / Mike Ledwidge, Tom Winter -- Abnormal liver function tests: jaundice / Julia A. Drose -- Fever of unknown origin / Heather Schierloh, Tom Winter -- Palpable left upper quadrant mass / Tom Winter -- Ultrasound of abdominal wall masses / Cynthia L Rapp -- Midabdominal mass: possible ascites / Teresa Bieker -- Pediatric abdominal masses / Marilyn J. Siegel -- Neonatal intracranial problems / Marilyn J. Siegel -- Spinal ultrasonography / Marilyn J. Siegel -- Developmental dysplasia of the infant hip / Lyndal Macpherson -- First trimester bleeding / Roger C. Sanders -- Acute pelvic pain / Roger C. Sanders -- Uncertain dates: elective cesarean section, "late registratant" / Roger C. Sanders, Nancy Smith Miner -- Second and third trimester bleeding / Roger C. Sanders -- Small for dates / Roger C. Sanders -- Large for dates / Roger C. Sanders -- Possible fetal anomalies / Roger C. Sanders -- Fetal well-being and fetal death / Mary McGrath-Ling -- Possible invasive rectal wall mass or anal sphincter break / Beverly E. Hashimoto -- Neck mass / Sara Baker, Tom Winter -- Possible testicular mass: pain in the testicle / Mike Ledwidge, Christine Labinski, Tom Winter -- Prostate: prostate carcinoma, benign prostatic hypertrophy / Teresa Bieker -- Penile problems: impotence, penile pain, and abnormal curvature / Mike Ledwidge, Tom Winter -- Breast ultrasound / Cynthia L. Rapp -- Infertility / Roger C. Sanders -- Rule out adnexal mass / Roger C. Sanders -- Midline pelvic mass / Roger C. Sanders -- Chronic pain / Roger C. Sanders -- Vaginal bleeding with negative pregnancy test / Roger C. Sanders -- Intrauterine contraceptive devices: "lost IUD" / Roger C. Sanders -- Right lower quadrant pain / Gretchen M. Dimling, Roger C. Sanders -- Possible adrenal mass / Tom Winter -- Renal failure / Barb Vanderwerff, Tom Winter -- Possible renal mass / Tim Walker, Tom Winter -- Unexplained hematocrit drop: rule out perinephric hematoma; possible perinephric pass / Barb Vanderwerff, Tom Winter -- Hematuria / Lisa Parsons, Tom Winter -- Rule out pleural effusion and chest mass / Mike Ledwidge, Tom Winter -- Transplants: renal, liver, pancreatic / Carol Mitchell, Tom Winter. Renal transplants ; Liver transplants ; Pancreatic transplants --
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    Overview -- Shoulder -- Elbow -- Wrist and hand -- Lower back and pelvis -- Knee -- Ankle and foot.
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    v. 1. Breast, 1962, rev. 1973 -- v. 2. Larynx, 1962, rev. 1972 -- v. 3. Reporting of cancer survival and end results, 1963 -- v. 4/5. Cervix and corpus uteri, 1964, rev. 1972 -- v. 6. Nasopharynx, oropharynx and hypopharynx, 1965 -- v. 7. Urinary bladder, 1967 -- v. 8. Thyroid, 1967 -- v. 9. Oral cavity, 1967 -- v. 10. Stomach, 1971, reprint 1974 -- v. 11. Esophagus, 1973 -- v. 12. Lung, 1973.
  • Diabetic retinopathy (DR) and its dramatic and sight-threatening complications, such as diabetic macular edema, remain a leading cause of visual impairment among the working-age population. With the advent of effective treatments, a new era in the management of DR has been opened up: it is now possible for patients to regain a degree of visual acuity not previously expected. However, amid the deluge of approved treatments and promising new strategies, clinicians may find it difficult to choose the appropriate practice in each individual case. The purpose of this easy-to-use and richly illustrated manual is to assist ophthalmologists in making decisions in the entire management of DR based on the best available evidence. Practical and complete recommendations are provided to guide clinicians in diagnosis, decision-making, and treatment. The manual includes practical algorithms and case histories relating to all stages of DR that clearly explain the progression of the disease and will help the clinician to choose the best therapeutic approach. It will be an ideal resource for ophthalmologists aiming to provide optimal clinical management for this sight-threatening disease.
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  • The impaired brain has often been difficult to rehabilitate owing to limited knowledge of the brain system. Recently, advanced imaging techniques such as fMRI and MEG have allowed researchers to investigate spatiotemporal dynamics in the living human brain. Consequently, knowledge in systems neuroscience is now rapidly growing. Advanced techniques have found practical application by providing new prosthetics, such as brain?machine interfaces, expanding the range of activities of persons with disabilities, or the elderly. The book?s chapters are authored by researchers from various research fields such as systems neuroscience, rehabilitation, neurology, psychology, and engineering. The book explores the latest advancements in neurorehabilitation, plasticity, and brain?machine interfaces among others, and constitutes a solid foundation for researchers who aim to contribute to the science of brain function disabilities and ultimately to the well-being of patients and the elderly worldwide.
  • The mainstay of orthopedic diagnosis continues to be the physical examination of the patient following a thorough history. This convenient pocketbook presents a comprehensive collection of the clinical tests that are used in orthopedic diagnosis, thereby answering the following questions: What tests are available for examining a particular joint, and how are they to be interpreted? What is meant by the name of a test that is mentioned in the literature or in a physician's report? The methodology and interpretation of all relevant test procedures are presented in almost 500 instructive drawings and brief descriptions: Initial tests, Functional tests, Stress tests, Stability tests. Tables on the examination of the spinal column, shoulder joint, and knee joint help in selecting the most suitable examinations. An invaluable aid for physical therapists, orthopedic surgeons, and primary care or emergency room physicians.
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  • "With examples based on the authors' 30 years of real-world experience in many areas of clinical drug development, this book provides a thorough presentation of clinical trial methodology. It presents detailed step-by-step illustrations on the implementation of the open-source software R. Case studies demonstrate how to select the appropriate clinical trial data. The authors introduce the corresponding biostatistical analysis methods, followed by the step-by-step data analysis using R. They also offer the R program for download, along with other essential data, on their website"--Provided by publisher.
  • "Now viewed as its own scientific discipline, clinical trial methodology encompasses the methods required for the protection of participants in a clinical trial and the methods necessary to provide a valid inference about the objective of the trial. Drawing from the authors courses on the subject as well as the first authors more than 30 years working in the pharmaceutical industry, Clinical trial methodology emphasizes the importance of statistical thinking in clinical research and presents the methodology as a key component of clinical research. From ethical issues and sample size considerations to adaptive design procedures and statistical analysis, the book first covers the methodology that spans every clinical trial regardless of the area of application. Crucial to the generic drug industry, bioequivalence clinical trials are then discussed. The authors describe a parallel bioequivalence clinical trial of six formulations incorporating group sequential procedures that permit sample size re-estimation. The final chapters incorporate real-world case studies of clinical trials from the authors own experiences. These examples include a landmark Phase III clinical trial involving the treatment of duodenal ulcers and Phase III clinical trials that contributed to the first drug approved for the treatment of Alzheimers disease. Aided by the U.S. FDA, the U.S. National Institutes of Health, the pharmaceutical industry, and academia, the area of clinical trial methodology has evolved over the last six decades into a scientific discipline. This guide explores the processes essential for developing and conducting a quality clinical trial protocol and providing quality data collection, biostatistical analyses, and a clinical study report, all while maintaining the highest standards of ethics and excellence"--Provided by publisher.
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    3. Variation in sensitivity between patients and standardization of treatment.
  • This edition includes both updates and new uses and issues concerning CTS, along with case studies of how clinical trial simulations are being applied in various therapeutic and application areas. Importantly, the book expands on the utility of CTS for informing decisions during drug development and regulatory review. Each chapter author was selected on the basis of demonstrated expertise in state-of-the-art application of CTS. The target audience for this volume includes researchers and scientists who wish to consider use of simulations in the design, analysis, or regulatory review and guidance of clinical trials. This book does not embrace all aspects of trial design, nor is it intended as a complete recipe for using computers to design trials. Rather, it is an information source that enables the reader to gain understanding of essential background and knowledge for practical applications of simulation for clinical trial design and analysis. It is assumed that the reader has a working understanding of pharmacokinetics and pharmacodynamics, modeling, pharmacometric analyses, and/or the drug development and regulatory processes.
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    Contains practical information on the design, conduct, and analysis of both single center and multicenter trials. Details issues such as sample size calculation, stratification and randomization, data systems design, development of consent forms, publication policies, preparation of funding requests, and reporting procedures. The author discusses the refinements and improvements made to methods and procedures, changes in the policies and guidelines underlying trials, as well as requirements for registration of trials. -- excerpt from publisher notes.
  • "This book comprises a series of critical reviews of the latest developments in clinical trials for psychopharmacologic drugs over the past decade. It evaluates key trials and their impact on management and treatment of specific disorders. Clearly written, the text provides immediate access to new developments across the spectrum of drug testing, written by the leaders in the field"--Provided by publisher.
  • Rheumatoid Arthritis -- Ankylosing Spondylitis -- Psoriatic Arthritis -- Systemic Lupus Erythematosus -- Antiphospholipid Syndrome -- Progressive Systemic Sclerosis -- Raynaud's Phenomenon -- Dermato/Polymyositis -- Sjögren's Syndrome -- Takayasu Arteritis -- Polymyalgia Rheumatica and Giant Cell Arteritis -- ANCA-Associated Vasculitis and combination trials of Churg-Strauss Syndrome and Polyarteritis Nodosa -- Henoch-Schönlein Purpura -- Behçet's Disease.
  • 2012 ClinicalKey
    The origins of drugs -- Introduction to regulated clinical trials -- Run in period -- Inclusion/exclusion criteria, stratification, and subgroups : part I -- Inclusion and stratification criteria : part II -- Randomization, allocation, and blinding -- Placebo arm as part of clinical study design -- Intent to treat analysis vs. per protocol analysis -- Biostatistics -- Introduction to endpoints for clinical trials in pharmacology -- Endpoints in clinical trials on solid tumors : objective response -- Oncology endpoints : overall survival and progression free survival -- Oncology endpoints : time to progression -- Oncology endpoint : disease free survival -- Oncology endpoint : time to distant metastasis -- Neoadjuvant therapy versus adjuvant therapy -- Hematological cancers -- Biomarkers and personalized medicine -- Endpoints in immune diseases -- Endpoints in clinical trials on infections -- Health related quality of life -- Health related quality of life instruments for immune disorders -- Health related quality of life instruments and infections -- Drug safety -- Mechanism of action : part I -- Mechanism of action, part II : cancer -- Mechanism of action, part III : immune disorders -- Mechanisms of action, part IV : infections -- Consent forms -- Package inserts -- Regulatory approval -- Patents.
  • 2011 ClinicalKey
    The new edition of Clinical Ultrasound has been thoroughly revised and up-dated by a brand new editorial team in order to incorporate the latest scanning technologies and their clinical applications in both adult and paediatric patients. With over 4,000 high quality illustrations, the book covers the entire gamut of organ systems and body parts where this modality is useful. It provides the ultrasound practitioner with a comprehensive, authoritative guide to image diagnosis and interpretation. Colour is now incorporated extensively throughout this edition in order to reflect the advances in clinical Doppler, power Doppler, contrast agents. Each chapter now follows a consistent organizational structure and now contains numerous summary boxes and charts in order to make the diagnostic process practical and easy to follow. Covering all of the core knowledge, skills and experience as recommended by the Royal College of Radiologists, it provides the Fellow with a knowledge base sufficient to pass professional certification examinations and provides the practitioner with a quick reference on all currently available diagnostic and therapeutic ultrasound imaging procedures. Contains over 4,000 high quality images (over 1,000 of which are in colour) to provide a comprehensive visual guide to help the practitioner identify and interpret diagnostic problems. Practical considerations such as image interpretation, image optimization techniques, pitfalls in technical acquisition and interpretation stressed throughout provide the trainee and practitioner with a new and improved knowledge in order to optimize clinical decision-making. Highlights the selection of other modalities (such as CT/MRI) whenever appropriate i.e. when there is a limited field of view or poor resolution and provides the user with a balanced perspective by referring to those occasions when ultrasound may not be the best modality to provide the best diagnostic information. Three brand new editors and many new contributing authors bring a fresh perspective on the content. Authoritative coverage of the most recent advances and latest developments in cutting edge technologies such as: colour Doppler, power Doppler, 3D and 4D applications, harmonic imaging, high intensity focused ultrasound (HIFU) microbubble contrast agents, interventional ultrasound , laparoscopic ultrasound brings this edition right up to date in terms of the changes in technology and the increasing capabilities/applications of ultrasound equipment. New sections on musculoskeletal imaging. Addition of coloured text, tables, and charts throughout will facilitate quick review and enhance comprehension. Individual chapters organized around common template therefore establishing a consistent diagnostic approach throughout the text and making the information easier to retrieve.
  • Uncertainty and clinical method -- Learning about uncertainty in professional practice -- Balint groups and peer supervision -- Research on Balint groups -- The thistle and the maple leaf: practice-based small-group learning in Canada and Scotland -- Narrative-based supervision -- Training in narrative-based supervision: conversations inviting change -- Practice inquiry: uncertainty learning in primary care practice -- Using practice inquiry to engage uncertainty in residency education -- "We're all in the same boat:" potentials and tensions when learning through sharing uncertainty in peer supervision groups -- Case-based learning in Swedish primary health care: strengths and challenges.
  • Non-alcoholic fatty liver disease / Bugianesi, E. -- Fibrosis in the GI tract : pathophysiology, diagnosis, and treatment options / Pinzani, M. -- Chronic hepatitis B : pathophysiology, diagnosis, and treatment options / Wursthorn, K.; Mederacke, I.; Manns, M.P. -- Chronic hepatitis C : pathophysiology, diagnosis, and treatment options / Asselah, T. ... [et al.] -- Clinical update on inflammatory disorders of the GI tract : liver transplantation / de Rougemont, O.; Dutkowski, P.; Clavien, P.-A. -- Hepatocellular carcinoma / Peck-Radosavljevic, M. -- Coeliac disease / Schuppan, D. -- Anti-TNF therapy in inflammatory bowel diseases / Fiorino, G.; Danese, S.; Peyrin-Biroulet, L. -- Role of epithelial cells in inflammatory bowel disease / Kaser, A. -- GI immune response in functional GI disorders / Tack, J.; Kindt, S. -- Probiotics in GI diseases / Gionchetti, P. ... [et al.] -- Microscopic colitis / Pardi, D.S.; Miehlke, S. -- Inflammatory proteins as prognostic markers in acute pancreatitis / Frossard, J.L.; Bhatia, M. -- Antibiotics, probiotics, and enteral nutrition : means to prevent infected necrosis in AP / van Doesburg, I.A. ... [et al.] on behalf of the Dutch Pancreatitis Study Group -- Immunotherapy of pancreatic carcinoma : recent advances / Märten, A.; Büchler, M.W. -- IKK/NF-B/Rel in acute pancreatitis and pancreatic cancer : torments of tantalus / Algül, H.; Schmid, R.M. -- Helicobacter pylori infection : to eradicate or not to eradicate / Schütte, K. ... [et al.] -- Clinical update on inflammatory disorder of the GI tract, carcinogenesis, and treatment of gastric cancer / Rad, R.; Ebert, M.
  • Andrology is a discipline united in a mission to achieve and maintain the sexual health of men, and more broadly couples, over the entire lifespan. In this volume, undisputed leading experts from Europe and beyond come together to cover the field in its entirety, providing a guide that will be of value to urologists and other physicians in their daily clinical practice. It is designed for a wide audience, including both those coming into contact with andrological issues for the first time and more experienced readers requiring updated guidelines and advice on the most controversial and thorny issues. A wide range of topics is covered, including male genital abnormalities, disorders of pubertal development, gender identity disorders, Peyronieℓ́ℓs disease, sexual dysfunction, hypogonadism and infertility, urogenital infections, urogenital cancers, and andrological emergencies. Clinical Andrology will prove an invaluable quick consulting tool, rigorous in its scientific content but at the same time easy to read and rich in images and tables.
  • 1. Anatomy and Physiology of Androgen Regulation in Men / Jerald Marifke and Jay Sandlow -- 2. Development of the Male Reproductive System / Pravin K. Rao and Arthur L. Burnett -- 3. Epidemiology and Diagnosis of Hypogonadism / Mikkel Fode, Susanne A. Quallich, Yacov Reisman, Jens Sønksen, and Dana A. Ohl -- 4. Testosterone and Sexual Function / Wayland Hsiao and John P. Mulhall 5. Treatment of Hypogonadism in Men / Akanksha Mehta, Darius A. Paduch, and Marc Goldstein -- 6. Hypogonadism and Prostate Cancer: To Treat or Not to Treat / Mohit Khera -- 7. Testosterone and Male Infertility / Tung-Chin Hsieh, Matthew McIntyre, and Larry Lipshultz -- 8. Specific Endocrinopathies and Male Infertility / Vincent Harisaran, Eugene Cone, and Kathleen Hwang.
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    Introduction / Douglas D. Richman, Richard J. Whitley, and Frederick G. Hayden -- Section I: Viral syndromes and general principles -- Respiratory infections / John J. Treanor -- Viral central nervous system infections / Kevin A. Cassady and Richard J. Whitley -- Gastrointestinal syndromes / Manish Patel and Roger I. Glass -- Viral hepatitis / Andrew W. Tai and Jules L. Dienstag -- Infections in organ transplant recipients / John A. Zaia -- Viral myocarditis / Jeffrey A. Towbin -- Viral infections of the skin / Brenda L. Bartlett and Stephen K. Tyring -- Viral hemorrhagic fevers: a comparative appraisal / Mike Bray and Karl M. Johnson -- Viral disease of the eye / Garry Shuttleworth and David Easty -- Antiretroviral agents / Magdalena E. Sobieszczyk, Barbara S. Taylor, and Scott M. Hammer -- Antiherpesvirus, anti-hepatitis virus, and anti-respiratory virus agents / Michael T. Yin ... [et al.] -- Diagnosis of viral infections / Guy Boivin ... [et al.] -- Immune responses to viruses / Jonathan W. Yewdell, Theodore C. Pierson, and Jack R. Bennink -- Immunization against viral diseases / Julie E. Martin and Barney S. Graham -- Gene therapy and viruses / Donald B. Kohn ... [et al.] -- Chronic fatigue and postinfective fatigue syndromes / Andrew R. Lloyd, Ian Hickie, and Denis Wakefield -- Section II: The agents -- Part A: DNA viruses -- Poxviruses / R. Mark Buller and Frank Fenner -- Herpes simplex viruses / Richard J. Whitley and Bernard Roizman -- Cercopithecine herpesvirus 1 (B virus) / Richard J. Whitley -- Varicella-zoster virus / Anne A. Gershon and Saul J. Silverstein -- Cytomegalovirus / Paul David Griffiths, Vincent Clive Emery, and Richard Milne -- Human herpesvirus 6 and human herpesvirus 7 / Koichi Yamanishi and Yasuko Mori -- Epstein-Barr virus / Katherine Luzuriaga and John L. Sullivan -- Kaposi's sarcoma-associated herpesvirus / Patrick S. Moore and Yuan Chang -- Adenoviruses / Olli Ruuskanen ... [et al.] -- Polyomaviruses / John E. Greenlee and Frank J. O'Neill -- Papillomavirus / William Bonnez -- Human Parvoviruses / Larry J. Anderson and Dean D. Erdman -- TT virus / Peter Simmonds -- Hepatitis B virus / Alexander J. V. Thompson, Sally J. Bell, and Stephen A. Locarnini -- Part B: RNA viruses -- Human lymphotropic viruses: HTLV-1 and HTLV-2 / William A. Blattner and Manhattan E. Charurat -- Human immunodeficiency virus / John C. Guatelli ... [et al.] -- Colorado tick fever virus and other arthropod-borne Reoviridae / Steven Yukl and Joseph K. Wong -- Rotaviruses / Manuel A. Franco and Harry B. Greenberg -- Respiratory syncytial virus, human metapneumovirus, and parainfluenza viruses / John V. Williams, Pedro A. Piedra, and Janet A. Englund -- Measles virus / William J. Moss and Diane E. Griffin -- Mumps virus / John W. Gnann, Jr. -- Zoonotic paramyxoviruses / Paul A. Rota, Thomas G. Ksiazek, and William J. Bellini -- Rhabdoviruses / Thomas P. Bleck and Charles E. Rupprecht -- Filoviruses / Mike Bray -- Influenza virus / Frederick G. Hayden and Peter Palese -- Bunyaviridae: bunyaviruses, phleboviruses, nairoviruses, and hantaviruses / Gregory J. Mertz -- Arenaviruses / C. J. Peters -- Enteroviruses / José R. Romero -- Rhinovirus / Ronald B. Turner and Wai-Ming Lee -- Hepatitis A virus / Philip R. Spradling, Annette Martin, and Stephen M. Feinstone -- Human caliciviruses / Robert L. Atmar and Mary K. Estes -- Hepatitis E virus / David A. Anderson and Iswar L. Shrestha -- Astrovirus / Ernesto Méndez and Carlos F. Arias -- Coronaviruses / Kenneth McIntosh and J. S. M. Peiris -- Arthropod-borne flaviviruses / Lyle R. Petersen and Alan D. T. Barrett -- Hepatitis C virus / Yaron Rotman and T. Jake Liang -- Alphaviruses / David W. Smith, John S. Mackenzie, and Scott C. Weaver -- Rubella virus / David W. Kimberlin -- Part C: Subviral agents -- Hepatitis D virus / Antonina Smedile, Alessia Ciancio, and Mario Rizzetto -- Transmissible spongiform encephalopathies / Adriano Aguzzi.
  • Clinical ward secrets 2010
    Finally, a book that answers the questions you have as you begin your clinical rotations. In this format of the Series, this book will help ease the transition from the classroom to the clinical wards. The popular Q&A format is an easy-to-use, didactic approach and covers all of the important procedures and processes you will need to know in the hospital, in the clinic, and on the ward. Throughout you will find valuable tips and "secrets" written by students and residents. This student-to-student approach ensures you are getting the most current and accurate information.
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    "Clinically Oriented Anatomy provides first-year medical students with the clinically oriented anatomical information as it relates to the practice of medicine, dentistry, and physical therapy. The 7th edition features a fully revised art program to ensure consistency and cohesiveness of imaging style"--Provided by publisher.
  • 1. Normal thoracic anatomy and common variants / Arlene Sirajuddin -- 2. Management of solitary pulmonary nodules / Maria C. Shiau, Elie Portnoy and Stuart M. Garay -- 3. Lung cancer / Todd R. Hazelton and Frank W. Walsh -- 4. Pulmonary infections in the normal host / Loren Ketai and Helen Katrina Busby -- 5. Pulmonary infections in the immunocompromised host / Jean W. Kuriakose and Barry H. Gross -- 6. Pleural disease / A. Keith Rastogi and Jeffrey P. Kanne -- 7. Pulmonary thromboembolic disease / Amie J. Tucker, Gopal Allada and Steven L. Primack -- 8. Non-thrombotic vascular disease of the chest / Elena Peña, Carole Dennie and George Chandy -- 9. Imaging of pulmonary hypertension / Mark L. Schiebler, James Runo, Leif Jensen and Christopher J. François -- 10. Obstructive pulmonary diseases / Megan Saettele, Timothy Saettele and Jonathan Chung -- 11. Imaging of airway disease / Shailaja J. Hayden and Sudhakar N. J. Pipavath -- 12. Idiopathic insterstitial pneumonias / Paul J. Lee and Jeffrey P. Kanne -- 13. Occupational lung disease / Cris A. Meyer and James E. Lockey -- 14. Hemoptysis / Kristie M. Guite, Trina J. Hollatz and Jeffrey P. Kanne -- 15. Non-AIDS immunologic diseases / Stephen A. Quinet and Jeffrey P. Kanne -- 16. Critically ill patient / Jie C. Nguyen and Jeffrey P. Kanne -- 17. Image guided thoracic interventions / Daniel Barnes, Kayvan Amjadi and Jean M. Seely.
  • The Clinicians Guide to ADHD combines the useful diagnostic and treatment approaches advocated in different guidelines with insights from other sources, including recent literature reviews and web resources. The aim is to provide clinicians with clear, concise, and reliable advice on how to approach this complex disorder. The guidelines referred to in compiling the book derive from authoritative sources in different regions of the world, including the United States, Canada, Australia, and Europe. After introductory discussion of epidemiology and etiology, guidance is provided on diagnosis in different age groups, differential diagnosis, assessment for potential comorbidities, and the issue of ADHD and driving. Advice is then given on the appropriate use of pharmacological and psychosocial treatment, the management of adverse events, and follow-up. A series of relevant scales, questionnaires, and websites are also included.
  • Carbamazepine -- Felbamate -- Gabapentin -- Lamotrigine -- Levetiracetam -- Oxcarbazepine -- Phenobarbital, primidone -- Phenytoin -- Pregabalin -- Tiagabine -- Topiramate -- Valproic -- Zonisamide.
  • This book is a concise guide to ordering radiology tests for diagnosis and treatment and provides best practice guidelines for patients whose management depends on a clinical question that is best approached through imaging. Organized primarily by organ system, it outlines considerations in selecting the most efficacious imaging studies based on the clinical history, laboratory values, and physical findings to arrive cost-effectively at a correct diagnosis. It also explores the current limitations of each imaging modality and presents evidence-based information to insure that patient safety.
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  • The Clinician's Guide to Swallowing Fluoroscopy is a comprehensive resource for all dysphagia clinicians. This beautifully-illustrated text is intended for SLP, ENT, radiology, GI, and rehabilitation specialists interested in swallowing and addresses the need for an up-to-date, all-inclusive reference. Topics covered include radiation safety and protection, fluoroscopic oral, pharygeal, and esophageal phase protocols and abnormalities, and objective measures of timing and displacement.
  • 1. The disease of obesity -- 2. The health burden of obesity -- 3. Psychosocial morbidity and the effect of weight loss -- 4. Dietary and lifestyle strategies for weight loss -- 5. Physical activity and writing an exercise prescription -- 6. The doctor's tool kit: pharmacolotherapy for the patient with obesity -- 7. Roux-en-Y gastric bypass: procedure and outcomes --- 8. Sleeve gastrectomy: procedure and outcomes -- 9. Laparoscopic adjustable gastric banding: procedure and outcomes -- 10. Perioperative care of the surgical patient -- 11. Surgical complications of weight loss surgery -- Index.
  • Contributors -- Preface -- General issues -- Overview of behavioral assessment with adults / William O'Donohue, Kendra K. Beitz, Michelle Byrd -- Psychometric considerations / Stephen N. Haynes -- Analogue and virtual reality assessment / Johan Rosqvist, Alecia Sundsmo, Chelsea MacLane, Kirsten Cullen, Darcy Clothier Norling, Mandy Davies, Danielle Maack -- Behavioral interviewing / Steven L. Sayers, Thomas J. Tomcho -- Activity measurement / Warren W. Tryon -- Structured and semi-structured interviews / Daniel L. Segal, Frederick L. Coolidge, Alisa O'Riley, Benjamin A. Heinz -- Self assessment / Sandra F. Sigmon, Stephanie M. LaMattina -- Psychophysiological assessment / Kevin T. Larkin -- Evaluation of specific disorders -- And problems -- Anxiety and fear / F. Dudley McGlynn, Todd A. Smitherman, Amanda M. M. Mulfinger -- Depression / Paula Truax, Aaron Tritch, Barb Carver -- Social skills deficit / Nina Heinrichs, Alexander L. Gerlach, Stefan G. Hofmann -- Eating disorders / Tiffany Stewart, Donald A. Williamson -- Alcohol and drug abuse / Peter M. Miller -- Marital dysfunction / Gary R. Birchler, William Fals-Stewart -- Sexual deviation / Nathanial McConaghy -- Psychotic behavior / Nirbhay N. Singh, Mohamed Sabaawi -- Aggressive behavior / Jennifer Langhinrichesen-Rohling, Matthew T. Huss, Martin L. Rohling -- Sleep dysfunction / Shawn Currie -- Borderline personality disorders / Wendi L. Adams, Tracy Jendritza, Soonie Kim -- Special issues -- Technology integration and behavioral assessment / David C. S. Richard, Andrew Gloster -- Evaluating older adults / Barry A. Edelstein. Erin Woodhead, Emily Bower, Angela Sweeney -- Behavioral neuropsychology / Michael D. Franzen -- Ethical-legal issues / William J. Fremouw, Jill Johansson-Love, Elizabeth Tyner, Julia Strunk -- Behavioral assessment of work-related issues / Derek R. Hopko, Sandra D. Hopko, C. W. Lejuez -- Assessment of value change in adults with acquired disabilities / Elias Mpofu, Thomas Oakland -- Index.
  • General issues -- Overview of behavioral assessment with children / David Reitman -- Developmental considerations / Susan Tinsley-Li, Sandra Rogers -- Psychometric considerations / Daniel M. Bagner, Michelle Harwood, Sheila M. Eyberg -- Analogue and virtual reality assessment / Sari D. Gold, Brian P. Marx -- Behavioral interviewing of parents / William G. Sharp, Cara B. Reeves, Alan M. Gross -- Activity measurement / Mark D. Rapport, Michael J. Kofler, Carmen Himmerich -- Structured and semistructured interviews / Helen Orvaschel -- Child self-regulation / Martin Agran, Michael L. Wehmeyer -- Psychophysiological assessment / Frank H. Wilhelm, Silvia Schneider, Bruce H. Friedman -- Peer sociometric evaluation / Elias Mpofu, JoLynn Carney, Michael C. Lambert -- Evaluation of specific disorders and problems -- Anxiety and fear / Janet Woodruff-Borden, Ovsanna T. Leyfer -- Depression / William M. Reynolds -- Social skill deficits / Megan M. McClelland, Cori Scalzo -- Alcohol and drug abuse / Brad C. Donohue, Jennifer Karmely, Marilyn J. Strada -- Peer relationship problems / Linda A. LeBlanc, Rachael A. Sautter, Dawn J. Dore -- Attention-deficit/hyperactivity disorder / Mark D. Rapport, Thomas M. Timko, Jr., Rachel Wolfe -- Eating disorders / Michelle Heffner Macera, J. Scott Mizes -- Mental retardation / V. Mark Durand, Kristin V. Christodulu -- Conduct disorders / Kurt A. Freeman, Jennifer M. Hogansen -- Pervasive development disorders / Laura Schreibman, Aubyn C. Stahmer, Natacha Akshoomoff -- Habit disorders / Michael B. Himle ... [et al.] -- Special issues -- Child abuse assessment / Deborah Wise -- Classroom assessment / Janine P. Stichter, Timothy J. Lewis -- Pediatric behavioral neuropsychology / Eileen B. Fennell -- Academic skills problems / Edward S. Shapiro, Milena A. Keller -- Ethical and legal issues / Catherine Miller.
  • This concise, yet practical handbook will aid in supporting the diagnosis, treatment, and long-term management of autism, including behavioral therapies, current clinical trials, and emerging pharmaceutical treatments. Autism spectrum disorder (ASD) is a developmental disorder characterised by disturbance in language, perception, and social skills that affects an estimated 1-2 per 1,000 people worldwide (although the number is as high as 20 per 1000 in the US). While studies have suggested a disturbance in neural metabolism in patients with ADS, the exact cause of the ASD still remains unknown. In 2013, a single indication of ASD, which united several related conditions (ie, classical autism, Asperger's syndrome, Fragile X Syndrome, Landau-Kleffner Syndrome, Rett syndrome, childhood disintegrative disorder, and PDD-NOS), was included in the fifth edition of the Diagnostic and Statistical Manual of Mood Disorders for the first time in order to support more standardized diagnoses.
  • "A thorough guide for readers to quickly gain an update on standard diagnosis and treatment methods for axial spondyloarthritis. Approximately 80 illustrations and images are used throughout the text to exemplify the disease and diagnostic and treatment algorithms. Easily accessible text and tables review the current treatment recommendations and emerging treatment options based on recent clinical trials."--Publisher's website.
  • pt. 1. The growth of lupus -- 1. Lupus: An introduction -- 2. What is lupus? -- pt. 2. Lupus organ by organ -- 3. Skin --4. Tendons and joints -- 5. Kidney -- 6. The brain -- 7. Heart and blood vessels -- 8. Liver and gastrointestinal tract -- 9. Blood -- pt. 3. Diagnosis and treatment -- 10. Diagnosing lupus -- 11. Treatment -- pt. 4. Lupus-like disorders -- 12. Sjögren's syndrome -- 13. Hughes syndrome (the antiphospholipid syndrome) -- 14. Mixed connective tissue disease (and overlap syndromes) -- 15. Vasculitis -- pt. 5. Lupus-related topics -- 16. Lupus-related topics.
  • A clinical manual on hypertension for primary care physicians. Serves as an up-to-date reference on hypertension for use in clinical practice. Includes dozens of clear and informative tables and figures to maximize comprehension. Addresses the most recentand crucial developments in a very common chronic condition. Gives a comprehensive review of currently available medications and combination therapy. Approximately one billion people worldwide are affected by hypertension. About 24% of the adult population in the US are hypertensive, and the number is expected to increase with the rising rates of obesity and diabetes. As hypertension affects so many and spans across varying ages, genders, ethnicities, and socioeconomic classes, all clinicians are likely to encounter patients with hypertension on regular basis. Hypertension is one of the major causes of cardiovascular diseases, and timely diagnosis and treatment are essential. The manual will give the reader a thorough overview of antihypertensive lifestyle modifications, first-line therapy, combination therapies, comorbid conditions, therapeutic challenges, and the latest trends in antihypertensive therapy. Pharmaceutical companies can use this clinician's manual as an excellent educational giveaway, as the booklet includes the latest clinical research results and treatment options for hypertension. The manual will give the reader a thorough overview of antihypertensive lifestyle modifications, first-line therapy, combination therapies, comorbid conditions, therapeutic challenges, and the latest trends in antihypertensive therapy. Pharmaceutical companies can use this clinician's manual as an excellent educational giveaway, as the booklet includes the latest clinical research results and treatment options for hypertension. The manual will give the reader a thorough overview of antihypertensive lifestyle modifications, first-line therapy, combination therapies, comorbid conditions, therapeutic challenges, and the latest trends in antihypertensive therapy. Pharmaceutical companies can use this clinician's manual as an excellent educational giveaway, as the booklet includes the latest clinical research results and treatment options for hypertension. Approximately one billion people worldwide are affected by hypertension. About 24% of the adult population in the US are hypertensive, and the number is expected to increase with the rising rates of obesity and diabetes. As hypertension affects so many and spans across varying ages, genders, ethnicities, and socioeconomic classes, all clinicians are likely to encounter patients with hypertension on regular basis. Hypertension is one of the major causes of cardiovascular diseases, and timely diagnosis and treatment are essential. The manual will give the reader a thorough overview of antihypertensive lifestyle modifications, first-line therapy, combination therapies, comorbid conditions, therapeutic challenges, and the latest trends in antihypertensive therapy. Pharmaceutical companies can use this clinician's manual as an excellent educational giveaway, as the booklet includes the latest clinical research results and treatment options for hypertension. The manual will give the reader a thorough overview of antihypertensive lifestyle modifications, first-line therapy, combination therapies, comorbid conditions, therapeutic challenges, and the latest trends in antihypertensive therapy. Pharmaceutical companies can use this clinician's manual as an excellent educational giveaway, as the booklet includes the latest clinical research results and treatment options for hypertension. The manual will give the reader a thorough overview of antihypertensive lifestyle modifications, first-line therapy, combination therapies, comorbid conditions, therapeutic challenges, and the latest trends in antihypertensive therapy. Pharmaceutical companies can use this clinician's manual as an excellent educational giveaway, as the booklet includes the latest clinical research results and treatment options for hypertension. Approximately one billion people worldwide are affected by hypertension. About 24% of the adult population in the US are hypertensive, and the number is expected to increase with the rising rates of obesity and diabetes. As hypertension affects so many and spans across varying ages, genders, ethnicities, and socioeconomic classes, all clinicians are likely to encounter patients with hypertension on regular basis. Hypertension is one of the major causes of cardiovascular diseases, and timely diagnosis and treatment are essential. The manual will give the reader a thorough overview of antihypertensive lifestyle modifications, first-line therapy, combination therapies, comorbid conditions, therapeutic challenges, and the latest trends in antihypertensive therapy. Pharmaceutical companies can use this clinician's manual as an excellent educational giveaway, as the booklet includes the latest clinical research results and treatment options for hypertension. The manual will give the reader a thorough overview of antihypertensive lifestyle modifications, first-line therapy, combination therapies, comorbid conditions, therapeutic challenges, and the latest trends in antihypertensive therapy. Pharmaceutical companies can use this clinician's manual as an excellent educational giveaway, as the booklet includes the latest clinical research results and treatment options for hypertension. The manual will give the reader a thorough overview of antihypertensive lifestyle modifications, first-line therapy, combination therapies, comorbid conditions, therapeutic challenges, and the latest trends in antihypertensive therapy. Pharmaceutical companies can use this clinician's manual as an excellent educational giveaway, as the booklet includes the latest clinical research results and treatment options for hypertension.
  • History and physical examination -- Chartwork -- Differential diagnosis: symptoms, signs, and conditions -- Laboratory diagnosis: chemistry, immunology, serology -- Laboratory diagnosis: clinical hematology -- Laboratory diagnosis: urine studies -- Clinical microbiology -- Blood gases and acid-base disorders -- Fluids and electrolytes -- Blood component therapy -- Nutritional assessment, therapeutic diets, and infant feeding -- Enteral and parenteral nutrition -- Bedside procedures -- Pain management -- Imaging studies -- Introduction to the operating room -- Suturing techniques and wound care -- Respiratory care -- Basic ECG reading -- Critical care -- Common medical emergencies -- Commonly used medications.
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  • ch. 1. An overview of childhood and adolescent ADHD : understanding the complexities of development into the adult years / Anne Teeter Ellison -- ch. 2. Continuity of ADHD in adulthood : hypothesis and theory meet reality / Sam Goldstein -- ch. 3. Research on comorbidity, adaptive functioning, and cognitive impairments in adults with ADHD : implications for a clinical practice / Russell Barkley and Michael Gordon -- ch. 4. The assessment process : conditions and comorbidities / Diane E. Johnson and C. Keith Conners -- ch. 5. Clinical case studies / Kevin Murphy -- ch. 6. The clinician's role in the treatment of ADHD / Kathleen G. Nadeau -- ch. 7. Changing the mindset of adults with ADHD : strategies for fostering hope, optimism, and resilience / Robert B. Brooks -- 8. A model of psychotherapy for adults with ADHD / Susan Young -- ch. 9. Pharmacotherapy of adult ADHD / Jeffrey B. Prince and Timothy E. Wilens -- ch. 10. Career impact : finding the key to issues facing adults with ADHD / Rob Crawford and Veronica Crawford -- ch. 11. What clinicians need to know about legal issues relative to ADHD / Peter S. Latham and Patricia H. Latham -- ch. 12. Making marriages work for individuals with ADHD / Patrick Kilcarr -- ch. 13. Families and ADHD / Thomas W. Phelan -- ch. 14. Life coaching for adult ADHD / Nancy Ratey -- ch. 15. Lifestyle issues / Arthur L. Robin.
  • This atlas reviews the spectrum of pathologies affecting the structures of the cardiovascular (CV) system most frequently encountered in sudden cardiac deaths, and has been conceived as a first step for making CV pathology diagnoses. It is almost impossible to establish an accurate diagnosis based only on morphology, and therefore this atlas is to assemble knowledge and points of view from two medical specialties, cardiology and forensic pathology. It has been designed as a practical visual reference that includes a summary of clinical characteristics, many high quality images and clear tables containing the main morphological characteristics of each disease. Clinico-Pathological Atlas of Cardiovascular Diseases has been written by cardiologists and forensic pathologists and histopathologists, which enables a combination approach in each chapter, to produce a thorough resource that will be of relevance to a wide range of specialists, including cardiologists, cardiac surgeons, interventional cardiologists, forensic doctors, and pathologists.
  • Clocks and rhythms 2007
    Cold Spring Harb Lab Press
    Introduction -- Clockworks -- Posttranscriptional and posttranslational mechanisms -- Genetics of rhythms -- Entrainment and peripheral clocks -- Systems approaches to biological clocks -- Models -- Development, proliferation, and aging -- Neuroanatomy and circuits -- Sleep, seasons, and mood.
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    The Commission on Social Determinants of Health was set up by former World Health Organization Director-General JW Lee. It was tasked to collect, collate, and synthesize global evidence on the social determinants of health and their impact on health inequity, and to make recommendations for action to address that inequity.
  • Clostridium difficile : new challenges for an old foe / Glenn S. Tillotson & Karl Weiss -- Clostridium difficile infection : a global threat / Nuttanun Suramaethakul & Teena Chopra -- Pathogenicity mechanisms of Clostridium difficile / Mark M. Collery, Revathi Govind, Nigel P. Minton & Sarah A. Kuehne -- Immunology and Clostridium difficile / Ciarán P. Kelly & Saurabh Sethi -- The microbiome and Clostridium difficile infection / Charles Y. Chiu & Dylan R. Pillai -- Economic burden of Clostridium difficile infection / Samuel L. Aitken, Dhara N. Shah & Kevin W. Garey -- Laboratory diagnosis of Clostridium difficile infection / Peter H. Gilligan -- Conventional therapeutics for Clostridium difficile infection / Jessica Martin & Mark Wilcox -- Infection control issues in Clostridium difficile / Scott Curry -- Future and alternative approaches to managing Clostridium difficile infection / Glenn S. Tillotson & Karl Weiss -- Recent advances with Clostridium difficile / Joni Tillotson & Glenn S. Tillotson -- Index.
  • "When it comes to the end of a relationship, the loss of a loved one, or even a national tragedy, we are often told we need 'closure.' But while some people do find closure for their pain and grief, many more feel that closure does not exist and believe the notion only encourages false hopes. Sociologist Nancy Berns explores these ideas and their ramifications in her timely book, Closure. Berns uncovers the various interpretations and contradictory meanings of closure. She identifies six types of 'closure talk,' revealing closure as a socially constructed concept and a 'new emotion.' Berns explores how closure has been applied widely in popular media and how the idea has been appropriated as a political tool and to sell products and services. This book explains how the push for closure--whether we find it helpful, engaging, or enraging--is changing our society."--Book cover.
  • 1. What are cloud services? -- 2. Benefits and drawbacks of cloud services -- 3. Cloud technologies -- 4. Cloud-based solutions for healthcare IT -- 5. HIPAA and HITECH : cloud perspective -- 6. Adopting cloud services -- 7. Interoperability -- 8. Cloud-based personal health records (PHR) -- 9. Case studies.
  • Variability between clusters -- Choosing whether to randomise by cluster -- Choice of clusters -- Matching and stratification -- Randomisation procedures -- Sample size -- Alternative study designs -- Basic principles of analysis -- Analysis based on cluster-level summaries -- Regression analysis based on individual level data -- Analysis of trials with more complex designs -- Ethnical considerations -- Data monitoring -- Reporting and interpretation.
  • This book, unique in focusing specifically on cardiac masses, is the result of cooperation among a number of teams of radiologists working under the aegis of the French Society of Cardiovascular Imaging (SFICV). Its goal is to 1) review the different CMR sequences and CT acquisition protocols used to explore cardiac masses, 2) to demonstrate the several CMR and MDCT features of cardiac masses. It has been designed as a teaching tool and offers a fully illustrated compendium of clinical cases, tables summarizing data, and decision-making trees essential in everyday practice. It is presented as a practical handbook and can be either read cover to cover or consulted whenever needed during a cardiac imaging assignment. The book is intended for all students and experienced practitioners, whether radiologists or not, who are interested in cardiac or thoracic pathology.
  • Covers three areas of research in brain tumors: a) animal models for brain tumors, including spontaneous occurrence of brain tumors in mammals, transgenic models in rodents and transplant models; b) Prognostic factors and biomarkers; c) Therapeutic targets and targeting approaches to brain tumors.
  • "This clinically oriented book covers selected infections of the central nervous system which are of considerable current interest. Aspects that are less well documented, such as spinal cord infections, central nervous system infections in patients with cancer, tropical infections, healthcare-associated ventriculitis or meningitis, and immunological problems in the international traveler are also discussed, as these are all problems relevant to daily practice."--Publisher's website.
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  • This book provides a comprehensive, state of the art overview covering both the diagnosis and the treatment of dual disorders ? joint psychiatric and substance use disorders ? in a way that is highly relevant to clinical work and the organization of care systems. It is designed to meet the real need for a European perspective on dual disorders, taking into account the realities of European treatment organization. All chapters have been written by European authors on the basis of existing European treatment programs or guidelines and European research. Dual disorders are increasingly encountered by health professionals working in mental health and addiction care, and they represent a formidable challenge for caregivers, care organizations, and society as a whole. During the past decade, various approaches and programs have been designed to challenge the traditional gap between addiction treatment and mental health care. The overwhelming majority of the programs, however, have emanated from the United States. Given the vast differences between the European and U.S. health contexts, it can be questioned whether these American-oriented treatment programs are of value in European countries. Co-occurring Addictive and Psychiatric Disorders ? A Practice-Based Handbook from a European Perspective therefore represents a timely and much-needed addition to literature on the subject.
  • There have been many changes in the field of coagulation during the past decade. New concepts of epidemiology of risk factors for thrombosis now help clinicians predict who is more likely to form clots after surgery, or after being placed on oral contraceptives. New anticoagulants have the potential to redefine how patients with atrial fibrillation and venous thrombosis are managed. There are new forms of recombinant clotting factors which have changed our approach to hypofibrinogenemia and von Willebrand's disease. Newer antiplatelet agents are available and their use in patients receiving cardiac stents has mushroomed. The management of thrombosis in the setting of pregnancy has changed over the past decade, as well as the way clinicians approach women with multiple miscarriages. An entire new class of compounds, the thrombopoietins, are available to treat individuals with immune thrombocytopenic purpura (ITP). The Coagulation Consult covers major topics of interest to hematologists who are asked to consult on individuals with coagulation related diseases, and encompasses the field's most recent developments. This "case-directed" book describes state-of-the-art approaches to patients with bleeding and clotting disorders, as well as laboratory tests for coagulation. Chapters include different vignettes, focus on typical clinical consult questions, and lay out specific types of treatment. Practicing clinicians being confronted with a coagulation consult, students, residents, fellows and attending physicians will find this unique text an invaluable resource for some of the newer areas of coagulation science, therapy and pharmacology.
  • "Why do some developing countries have more efficient health systems and better health outcomes? Contrary to existing theory that posits the superiority of proportional representation (PR) rules on public-goods provision, this book argues that electoral rules function differently given the underlying ethnic structure. In countries with low ethnic salience, PR has the same positive effect as in past theories. In countries with high ethnic salience, the geographic distribution of ethnic groups further matters: where they are intermixed, PR rules are worse for health outcomes; where they are isolated, neither rule is superior. The theory is supported through a combination of careful analysis of electoral reform in individual country cases with numerous well-designed cross-country comparisons. The case studies include Thailand, Mauritius, Malaysia, Botswana, Burma and Indonesia. The theory has broad implications for electoral rule design and suggests a middle ground in the debate between the Consociational and Centripetal schools of thought"-- Provided by publisher.
  • This is the first book completely devoted to exploring the state-of-the-art course-graining techniques for molecular simulations. Leading contributors discuss a broad range of topics, including nucleic acids, minimalist models for protein folding, mixed resolution course graining and elastic network models of protein complexes.
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  • Metallic cobalt particles (with or without tungsten carbide) -- Introduction to the monographs on gallium arsenide and indium phosphide. Studies of cancer in humans -- Gallium arsenide -- Indium phosphide -- Vanadium pentoxide.
  • History of cochlear implants and auditory brainstem implants / Moller A.R. -- Surgical aspects of cochlear implantation: mechanisms of insertional trauma / Roland P.S., Wright C.G. -- Histopathology of the inner ear relevant to cochlear implantation / Nadol J.B. Jr., Eddington D.K. -- Factors influencing spoken language outcomes in children following early cochlear implantation / Geers A.E. -- Central auditory development in children with cochlear implants: clinical implications / Sharma A., Dorman M.F. -- Brain plasticity under cochlear implant stimulation / Kral A., Tillein J. -- Speech processing in vocoder-centric cochlear implants / Loizou P.C. -- Auditory brainstem implants: surgical aspects / Fayad J.N., Otto S.R., Brackmann D.E. -- A guide to the positioning of brainstem implants using inraoperative electrical auditory brainstem responses / Nevison B. -- Auditory outcomes in tumor vs. nontumor patients fitted with auditory brainstem implant / Colletti V. -- Basis of electrical stimulation of the cochlea and the cochlear nucleus / Shepherd R.K., McCreery D.B. -- Physiological basis for cochlear and auditory brainstem implants / Moller A.R.
  • Electric acoustic stimulation : a new era in prosthetic hearing rehabilitation / van de Heyning, P., Kleine Punte, A. -- Hearing preservation in cochlear implantation and drug treatment / Barriat, S. ... [et al.] -- Ganglion cell and dendrite populations in electric acoustic stimulation ears / Rask-Andersen, H., Liu, W., Linthicum, F. -- Electrode features for hearing preservation and drug delivery strategies / Jolly, C. .. [et al.] -- Detection of dead regions in the cochlea : relevance for combined electric and acoustic stimulation / Moore, B.C.J., Glasberg, B., Schlueter, A. -- Psychophysical properties of low-frequency hearing : implications for perceiving speech and music via electric and acoustic stimulation / Gifford, R.H., Dorman, M.F., Brown, C.A. -- Neuronal responses in cat inferior colliculus to combined acoustic and electric stimulation / Vollmer, M., Hartmann, R., Tillein, J. -- Music perception in electric acoustic stimulation users as assessed by the MU. S.I.C. test / Brockmeier, S.J. ... [et al.] -- Acceptance and fitting of the DUET device : a combined speech processor for electric acoustic stimulation / Helbig, S., Baumann, U. -- From electric acoustic stimulation to improved sound coding in cochlear implants / Nopp, P., Polak, M. -- Minimizing intracochlear trauma during cochlear implantation / Adunka, O.F., Pillsbury, H.C., Buchman, C.A. -- Hearing preservation surgery : current opinions / Fitzgerald O'Connor, E., Fitzgerald O'Connor, A. -- Electric acoustic stimulation in patients with postlingual severe high-frequency hearing loss : clinical experience / Arnoldner, C. ... [et al.] -- The hybrid cochlear implant : a review / Woodson, E.A. ... [et al.] -- Electric acoustic stimulation in children / Skarzynski, H., Lorens, A. -- Bilateral electric acoustic stimulation : a comparison of partial and deep cochlear electrode insertion : a longitudinal case study / Kleine Punte, A., Vermeire, K., van de Heyning, P.
  • "The Cochrane Handbook for Systematic Reviews of Interventions (the Handbook) provides guidance to authors for the preparation of Cochrane Intervention reviews (including Cochrane Overviews of reviews)." "The Handbook is updated regularly to reflect advances in systematic review methodology and in response to feedback from users. Please refer to the web site for the most recent version, for interim updates to the guidance and for details of previous versions of the Handbook."
  • Part 1. Abdominal -- part 2. Airway -- part 3. Cardiothoracic -- part 4. Neurosurgical -- part 5. Vascular -- part 6. Other -- part 7. Emergency medical management.
  • Codes of biosequences / Edward N. Trifonov -- The mechanisms of evolution : natural selection and natural conventions / Marcello Barbieri -- Catalytic propensity of amino acids and the origins of the genetic code and proteins / Ádám Kun ... [et al.] -- Why the genetic code originated : implications for the origin of protein synthesis / Massimo Di Giulio -- Self-referential formation of the genetic system / Romeu Cardoso Guimarães, Carlos Henrique Costa Moreira, and Sávio Torres de Farias -- The mathematical structure of the genetic code / Diego L. Gonzalez -- The arithmetical origin of the genetic code / Vladimir shCherbak -- Protein linguistics and the modular code of the cytoskeleton / Mario Gimona -- A lipid-based code in nuclear signaling / Nadir M. Maraldi -- Biological information transfer beyond the genetic code : the sugar code / Hans-Joachim Gabius -- The immune self code : from correspondence to complexity / Yair Neuman -- Signal transduction codes and cell fate / Marcella Faria -- Towards an understanding of language origins / Eörs Szathmáry -- The codes of language : turtles all the way up? / Stephen J. Cowley -- Code and context in gene expression, cognition, and consciousness / Seán Ó Nualláin -- Neural coding in the neuroheuristic perspective / Alessandro E.P. Villa -- Error detection and correction codes / Diego L. Gonzalez -- The musical code between nature and nurture : ecosemiotic and neurobiological claims / Mark Reybrouck.
  • Plant cell calcium, past and future / Anthony J. Trewavas -- Calcium signalilng and homeostasis in nuclei / Christian Mazars .. [et al.] --Interactions between calcium and ROP signaling regulate pollen tube tip growth / Augusta Jamin and Zhenbiao Yang -- Calcium, mechanical signaling, and tip growth / Won-Gyu Choi, Sarah J. Swanson, and Simon Gilroy -- Calcium signals in the control of stomatal movements / Alex A.R. Webb and Fiona C. Robertson -- Stimulus perception and membrane excitation in unicellular alga Chlamydomonas / Kenjiro Yoshimura -- Cyclic nucleotide gated channels (CNGCs) and the generation of Ca2+ signals / Wei Ma and Gerald A. Berkowitz -- Annexins / Anuphon Laohavisit and Julia M. Davies -- Structure and function of CDPK : a sensor responder of calcium / Yohsuke Takahashi and Takeshi Ito -- Elucidation of calcium-signaling components and networks / Irene S. Day and A.S.N. Reddy -- Decoding of calcium signal through calmodulin : calmodulin-binding proteins in plants / Liqun Du [and others] / The CBL-CIPK network for decoding calcium signals in plants / Oliver Batistic [and others].
  • Cognition 2015
    Cold Spring Harbor Lab Press
  • This new graduate level textbook, Cognition and Acquired Language Disorders: An Information Processing Approach, addresses the cognitive aspects of language and communication. It assembles the most recent information on this topic, addressing normal cognitive processing for language in adults, the cognitive impairments underlying language disorders arising from a variety of neurologic conditions, and current assessment and treatment strategies for the management of these disorders. The text is organized using an information processing approach to acquired language disorders, and thus can be set apart from texts that rely upon a more traditional, syndrome-based approach (e.g., stroke, dementia, and traumatic brain injury). This approach facilitates the description and treatment of acquired language disorders across many neurologic groups when particular cognitive deficits are identified. Other useful features of the text include assessment and treatment protocols that are based on current evidence. These protocols provide students and clinicians a ready clinical resource for managing language disorders due to deficits in attention, memory, linguistic operations, and executive functions. Unique process-oriented approach organizes content by cognitive processes instead of by syndromes so you can apply the information and treatment approaches to any one of many neurologic groups with the same cognitive deficit. Cognitive domains are described as they relate to communication rather than separated as they are in many other publications where they are treated as independent behaviors. A separate section on normal processing includes five chapters providing a strong foundation for understanding the factors that contribute to disordered communication and its management. The evidence-based approach promotes best practices for the most effective management of patients with cognitive-communication disorders. Coverage of the cognitive aspects of communication helps you meet the standards for certification in speech-language pathology. A strong author team includes two lead authors who are well known and highly respected in the academic community, along with expert contributors, ensuring a comprehensive, advanced clinical text/reference.
  • Historical development of cognitive therapy -- Cognitive model and theory of psychopathology -- Case formulation -- The patient-therapist relationship -- Tools of treatment -- Structure of sessions -- Resistance -- Termination -- Affective disorders -- Anxiety disorders -- Personality disorders and dialectical behavior therapy -- Medication adherence.
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  • Foreword / by Jane Goodall -- Sociocognitive development in chimpanzees : a synthesis of laboratory work and fieldwork / T. Matsuzawa -- A new comparative perspective on prenatal motor behaviors : preliminary research with four-dimensional ultrasonography / H. Takeshita, M. Myowa-Yamakoshi, S. Hirata -- Cognitive abilities before birth : learning and long-lasting memory in a chimpanzee fetus / N. Kawai -- Spindle neurons in the anterior cingulate cortex of humans and great apes / M. Hayashi -- Descent of the larynx in chimpanzees : mosaic and multiple-step evolution of the foundations for human speech / T. Nishimura -- Understanding the growth pattern of chimpanzees : does it conserve the pattern of the common ancestor of humans and chimpanzees? / Y. Hamada, T. Udono -- The application of a human personality test to chimpanzees and survey of polymorphism in genes relating to neurotransmitters and hormones / M. Inoue-Murayama ... [et al.] -- Evolutionary origins of the human mother-infant relationship / T. Matsuzawa -- Development of facial information processing in nonhuman primates / M. Myowa-Yamakoshi -- Development of joint attention in infant chimpanzees / S. Okamoto-Barth, M. Tomonaga -- Food sharing and referencing behavior in chimpanzee mother and infant / A. Ueno -- Development of chimpanzee social cognition in the first 2 years of life / M. Tomonaga -- Chimpanzee learning and transmission of tool use to fish for honey / S. Hirata -- How and when do chimpanzees acquire the ability to imitate? / M. Myowa-Yamakoshi -- Yawning : an opening into empathy? / J.R. Anderson, T. Matsuzawa -- How social influences affect food neophobia in captive chimpanzees : a comparative approach / E. Addessi, E. Visalberghi -- Tactical deception and understanding of others in chimpanzees / S. Hirata -- Early spontaneous categorization in primate infants - chimpanzees, humans, and Japanese macaques - with the familiarization-novelty preference task / C. Murai -- Processing of shadow information in chimpanzee (Pan troglodytes) and human (Homo sapiens) infants / T. Imura, M. Tomonaga, A. Yagi -- Color recognition in chimpanzees (Pan troglodytes) / T. Matsuno, N. Kawai, T. Matsuzawa -- Auditory-visual crossmodal representations of species-specific vocalizations / A. Izumi -- Spontaneous categorization of natural objects in chimpanzees / M. Tanaka -- Cognitive enrichment in chimpanzees : an approach of welfare entailing an animal's entire resources / N. Morimura -- Cognitive development in apes and humans assessed by object manipulation / M. Hayashi, H. Takeshita, T. Matsuzawa -- Token use by chimpanzees (Pan troglodytes) : choice, metatool, and cost / C. Sousa, T. Matsuzawa -- Behavioral repertoire of tool use in the wild chimpanzees at Bossou / G. Ohashi -- Ant dipping in chimpanzees : an example of how microecological variables, tool use, and culture reflect the cognitive abilities of chimpanzees / T. Humle -- Ontogeny and cultural propagation of tool use by wild chimpanzees at Bossou, Guinea : case studies in nut cracking and leaf folding / D. Biro, C. Sousa, T. Matsuzawa.
  • "This book highlights the behavioral and neurobiological issues relevant for drug development, reviews evidence for an innovative approach for drug discovery and presents perspectives on multiple special topics ranging from therapeutic drug use in children, emerging technologies and non-pharmacological approaches to cognitive enhancement."--Publisher's website.
  • Medical and Psychosocial Aspects of Cognitive Enhancement -- Pharmacological Neuroenhancement: Substances and Epidemiology / Andreas G. Franke, Klaus Lieb -- Psychopharmacological Neuroenhancement: Evidence on Safety and Efficacy / Dimitris Repantis -- A Bubble of Enthusiasm: How Prevalent Is the Use of Prescription Stimulants for Cognitive Enhancement? / Bradley Partridge -- Modeling the Effects of Modafinil on Selective Attention Electroencephalographic Neural Correlates / Carlos Trenado -- Behavioral Neuroenhancement / Martin Dresler -- The Influence of Sports on Cognitive Task Performance - A Critical Overview / Pavel Dietz -- The Human Experiment: How We Won't Win the Rat Race. What Can We Learn from Brain Stimulation in Humans and Rats About Enhancing the Functional Neurobiology of Higher Cognitive Functions? / Colleen A. Dockery -- Philosophical and Ethical Aspects of Cognitive Enhancement -- Better Brains or Bitter Brains? The Ethics of Neuroenhancement / Kirsten Brukamp -- Cognitive Enhancement - To What End? / Michael Hauskeller -- Nano-bionic Devices for the Purpose of Cognitive Enhancement: Toward a Preliminary Ethical Framework / Frédéric Gilbert -- Cognitive-Enhancing Drugs, Behavioral Training and the Mechanism of Cognitive Enhancement / Emma Peng Chien -- What Is Cognitive Enhancement and Is It Justified to Point Out This Kind of Enhancement Within the Ethical Discussion? / Roland Kipke -- No Pain, No Gain? Objections to the Use of Cognitive Enhancement on the Basis of Its Potential Effects on the Value of Achievement / Lisa Forsberg -- Does the Cognitive Enhancement Debate Call for a Renewal of the Deliberative Role of Bioethics? / Cynthia Forlini, Eric Racine -- Sociological, Political and Legal Aspects of Cognitive Enhancement -- The Biopolitics of Cognitive Enhancement / Peter B. Reiner -- Are We Heading Towards an 'Enhancement Society'? / Armin Grunwald -- Leveling the Playing Field: Fairness in the Cognitive Enhancement Debate / Greta Wagner -- My Mind Is Mine!? Cognitive Liberty as a Legal Concept / Jan-Christoph Bublitz -- Cognitive Enhancement and Criminal Behavior / Elizabeth Shaw -- Enhanced Control and Criminal Responsibility / John Danaher.
  • "Enormous advances in information technology have permeated essentially all facets of life in the past two decades. Formidable challenges remain in fostering tools that enhance productivity but are sensitive to work practices. Cognitive Informatics (CI) is the multidisciplinary study of cognition, information and computational sciences that investigates all facets of human computing including design and computer-mediated intelligent action, thus is strongly grounded in methods and theories from cognitive science. As an applied discipline, it has a close affiliation with human factors and human-computer interaction, and provides a framework for the analysis and modeling of complex human performance in technology-mediated settings and contributes to the design and development of better information systems. In recent years, CI has emerged as a distinct area with special relevance to biomedicine and health care. In addition, it has become a foundation for education and training of health informaticians, the Office of the National Coordinator for Health Information Technology initiating a program including CI as one of its critical elements to support health IT curriculum development. This book represents a first textbook on cognitive informatics and will focus on key examples drawn from the application of methods and theories from CI to challenges pertaining to the practice of critical-care medicine (CCM). Technology is transforming critical care workflows and re-organizing patient care management processes. CCM has proven to be a fertile test bed for theories and methods of cognitive informatics. CI, in turn, has contributed much to our understanding of the factors that result in complexity and patient errors. The topic is strongly interdisciplinary and will be important for individuals from a range of academic and professional backgrounds, including critical care specialists, psychologists, computer scientists, medical informaticians, and anthropologists"--Provided by publisher.
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    Cognitive neuroscience of aging: emergence of a new discipline / Roberto Cabeza, Lars Nyberg, Denise C. Park -- The aging brain observed in vivo: differential changes and their modifiers / Naftali Raz -- The role of dopamine systems in cognitive aging / Lars Bäckman, Lars Farde -- Electrophysiological and optical measures of cognitive aging / Monica Fabiani, Gabriele Gratton -- BOLD functional MRI and cognitive aging / Adam H. Gazzaley, Mark D'Esposito -- The relationship between brain activity, cognitive performance, and aging: the case of memory -- Michael D. Rugg, Alexa M. Morcom -- -- Age-related changes in neural activity during visual perception and attention / David J. Madden, Wythe L. Whiting, Scott A. Huettel -- The cognitive neuroscience of working memory and aging / Patricia A. Reuter-Lorenz, Ching-Yune C. Sylvester -- Long-term memory and aging: a cognitive neuroscience perspective / Denise C. Park, Angela H. Gutchess -- The neural basis of age-related declines in prospective memory / Robert West -- -- Three principles for cognitive aging research: multiple causes and sequelae, variance in expression and response, and the need for integrative theory / Randy L. Buckner -- Functional connectivity during memory tasks in healthy aging and dementia / Cheryl L. Grady -- Cognitive training in healthy aging: a cognitive neuroscience perspective / Lars Nyberg -- -- Age-related changes in hemispheric organization / Sander Daselaar, Roberto Cabeza -- Neurocomputational perspectives linking neuromodulation, processing noise, representational distinctiveness, and cognitive aging / Shu-Chen Li.
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    A brief history of cognitive neuroscience -- Cellular mechanisms and cognition -- Neuroanatomy and development -- Methods of cognitive neuroscience -- Sensation and perception -- Object recognition -- The control of action -- Learning and memory -- Emotion -- Language -- Hemispheric specialization -- Attention and consciousness -- Cognitive control -- Social cognition -- Evolutionary perspectives.
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    A brief history of cognitive neuroscience -- Structure and function of the nervous system -- Methods of cognitive neuroscience -- Hemispheric specialization -- Sensation and perception -- Object recognition -- Attention -- Control of action -- Memory -- Emotion -- Language -- Cognitive control -- Social cognition -- Consciousness, free will, and the law.
  • The fourth edition of The Cognitive Neurosciences continues to chart new directions in the study of the biologic underpinnings of complex cognition--the relationship between the structural and physiological mechanisms of the nervous system and the psychological reality of the mind. Since the publication of the third edition, the field of cognitive neuroscience has made rapid and dramatic advances; fundamental stances are changing and new ideas are emerging. This edition reflects the vibrancy of the field, with research in development and evolution that finds a dynamic growth pattern becoming specific and fixed, and research in plasticity that sees the neuronal systems always changing; exciting new empirical evidence on attention that also verifies many central tenets of longstanding theories; work that shows the boundaries of the motor system pushed further into cognition; memory research that, paradoxically, provides insight into how humans imagine future events; pioneering theoretical and methodological work in vision; new findings on how genes and experience shape the language faculty; new ideas about how the emotional brain develops and operates; and research on consciousness that ranges from a novel mechanism for how the brain generates the baseline activity necessary to sustain conscious experience to a bold theoretical attempt to make the problem of qualia more tractable.
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    I. Developmental and evolutionary cognitive neuroscience -- II. Plasticity and learning -- III. Visual attention -- IV. Sensation and perception -- V. Motor systems and action -- VI. Memory -- VII. Language and abstract thought -- VIII. Social neuroscience and emotion -- IX. Consciousness -- X. Advances in methodology -- XI. Neuroscience and society.
  • It is now more than ever critical to have a reference to highlight the applicable embryology, anatomy, histology, and pathophysiology of surgical diseases and how these relate to critical tissue planes, surgical pitfalls, and technical pearls. This text is organized by organ system and the illustrations highlight surgical pearls borne of experience and polished by the study of pertinent references. Hand-drawn and illustrated figures show exact anatomical relationships as we see them in-vivo. A question/answer format augments the images to allow the reader to actively reflect on the topic and to appraise his/her knowledge in that area. The discussion sections strive to explain not only what the correct answer is, but also why the distractors are wrong, in order to motivate discussion and self-reflection. Cognitive Pearls in General Surgery details the explicit thought processes and associations that underlie the understanding of the topics at hand, with the intent of enhancing the fun and enjoyment that only an informed and well-grounded practice of surgery can provide.
  • 1. History of Cognitive Rehabilitation -- 2. The Role of Assessment in Treatment Planning -- 3. Treatment Strategies -- 4. Cognitive Remediation with NeurXercise -- 5. Treatment Generalization and Ecological Validity -- 6. A NeurXercise Casebook -- 7. Conclusions -- Appendicies A-N.
  • Self-organization in the nervous system / David Willshaw -- Large-scale, small-scale systems / Jim Austin ... [et al.] -- Representation / Vincent Walsh and Simon Laughlin -- Sensory processing / Lionel Tarassenko and Mike Denham -- Speech and language / William D. Marslen-Wilson -- Action / Philip Barnard and Peter Redgrave -- Social cognition / Uta Frith and Sarah-Jayne Blakemore -- Motivation, planning and interaction / Nicholas R. Jennings and Anthony G. Cohn ... [et al.] -- Learning and memory / Richard Morris ... [et al.] -- Memory, reasoning and learning / Kieron O'Hara ... [et al.] -- Advanced neuroscience technologies / Bashir Ahmed ... [et al.] -- Applications and impact / Bill Sharpe.
  • "Completely updated to keep you absolutely current, this comprehensive reference remains the definitive text for the classroom and clinical practice. The tenth edition offers a superb full-color design and integrates the latest evidence-based research for clinical treatments. It includes coverage from preparing the clinician and patient for endodontic treatment to the role an endodontist can play in the treatment of traumatic injuries, to the procedures used in the treatment of both pediatric and older patients. Providing the latest in treating endodontic infections and pain, and in establishing differential diagnoses, this is a one-stop resource!"--BOOK JACKET.
  • Addressing methods particularly valuable to cold cases, the book provides information on cold case reconstruction, investigative techniques, and case reviews. The author merges theory with practice using case histories, photographs, illustrations, and checklists to convey concepts and provide a practical basis for cold cases. He combines techniques from forensics, psychology, and criminal investigation that have proven effective in this field, paying special attention to technologies that may not have been available at the time of the crime. Coverage includes the legal perspective of following a cold case from reopening through trial.
  • The Normal Biopsy: Mucosa And Submucosa -- The Endoscopic Biopsy -- Elementary Lesions Of Inflammation -- Dysplasia -- Infections -- Inflammatory Bowel Diseases -- Treatment Related Diseases -- Ischemic Colitis -- Diverticular Disease-Associated Colitis -- Eosinophilic Colitis -- Microscopic Colitis -- Drug-Induced Colitis -- Solitary Rectal Ulcer Syndrome -- The Role Of Biopsies In The Treatment Of Colitis: Scoring Of Disease Activity.
  • Describes the COMPASS model for working with preschool and elementary age students with autism spectrum disorders. This book offers a framework for individualized assessment and program planning based in students' life experiences along with family and teacher input. At the same time, its two-tiered consultation/coaching strategy is designed to minimize the setbacks that occur even in optimal family and classroom situations. Featured in the text: theory and rationale behind COMPASS; self-evaluation tools for assessing core skills and competencies; guidelines for writing effective Individual Education Programs and the COMPASS Action Plan; detailed instructions for implementing Action Plans and monitoring progress; case studies of the COMPASS program in real-life situations; a complete kit of forms, scales, and checklists.
  • One of the challenges the field of clinical neuropsychology faces is to develop an assessment process that is relevant and responsive to the needs of patients. This book describes developments in methods of neuropsychological assessment feedback that involve patients in an open exchange of information and results.
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    The Library maintains a collection of articles on the rankings of hospitals in the United States.
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    The Library maintains a collection of articles on the rankings of graduate schools or medical schools in the United States and Canada.
  • Surfactants and block copolymers in drug delivery / Ambikanandan Misra ... [et al.] -- Application of colloidal properties in drug delivery / Swarnlata Saraf -- Polymeric nanocapsules for drug delivery : an overview / Sílvia S. Guterres ... [et al.] -- Poly(alkyl cyanoacrylate) nanoparticles for drug delivery and vaccine development / Anja Graf, Karen Krauel-Göllner, Thomas Rades -- Stimuli-sensitive polymer gels for dermal and transdermal drug delivery and their application in the development of smart textile materials / Witold Musial and Vanja Kokol -- Micelles : the multifunctional nanocarrier for colloidal drug delivery / Chandana Mohanty, Sarbari Acharya, and Sanjeeb K. Sahoo -- Multiple emulsions : an overview and pharmaceutical applications / Jatin Khurana, Somnath Singh, and Alekha K. Dash -- Pharmaceutical and biotechnological applications of multiple emulsions / Rita Cortesi and Elisabetta Esposito -- Nanoemulsions as drug delivery systems / Figen Tirnaksiz, Seyda Akkus, and Nevin Celebi -- Microemulsion systems : application in delivery of poorly soluble drugs / Ljiljana Djekic and Marija Primorac -- Diclofenac solubilization in mixed nonionic surfactants microemulsions / Monzer Fanun -- Self-emulsifying drug delivery systems / D. P. Maurya, Yasmin Sultana, and M. Abul Kalam -- Liquid crystals and their application in the field of drug delivery / Rakesh Patel and Tanmay N. Patel -- Liquid crystalline nanoparticles as drug nanocarriers / Anan Yaghmur and Michael Rappolt -- Niosomal delivery system for macromolecular drugs / Yongzhuo Huang, Faquan Yu, and Wenquan Liang -- A new class of mesoscopic aggregates as a novel drug delivery system / Federico Bordi, Cesare Cametti, and Simona Sennato -- Liposomes and biomacromolecules : effects of preparation protocol on in vitro activity / Paola Luciani, Debora Berti, and Piero Baglioni -- Colloidal nanocarrier systems as a tool for improving antimycobacterial and antitumor activities and reducing the toxicity of usnic acid / N. S. Santos-Magalhães ... [et al.] -- Dendrimers in drug delivery / Hu Yang -- Microsphere : a novel drug delivery system / Abdus Samad ... [et al.] -- Colloids in aerosol drug delivery system / Nazrul Islam -- Respiratory aerosol dynamics with applications to pharmaceutical drug delivery / Jinxiang Xi, P. Worth Longest, and Paula J. Anderson -- Colloidal carriers for drug delivery in dental tissue engineering / Nader Kalaji, Nida Sheibat-Othman, and Hatem Fessi -- Classification and application of colloidal drug delivery systems : passive or active tumor targeting / H. Yesim Karasulu, Burcak Karaca, and Ercüment Karasulu -- Nanocarriers for imaging applications / Vandana Patravale and Medha Joshi.
  • This book explains clearly the nature of colon polyps and their relationship with colorectal cancer, which is among the three most common cancers in both men and women. Up-to-date information is provided on anatomy, pathology, types of polyp and their treatment, and the performance of colonoscopy. Particular attention is devoted to the risk factors for development of colorectal cancer, with detailed guidance on its prevention and early diagnosis and treatment. While the book is primarily intended for medical specialists and students, a deliberate and consistent effort has been made to use plain language that will enable other interested persons, including patients, to understand all aspects of the subject.
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    "Focusing on yellow fever, cholera, and plague epidemics as well as on sanitation in the context of urban growth in Saint-Louis-du-Senegal between 1867 and 1920, this book explores how the French colonial and medical authorities responded to the emergence and re-emergence of deadly epidemic diseases and environmental contamination. Official reactions ranged from blaming the Africans and the tropical climate to the imposition of urban residential segregation and strictly enforced furloughs of civil servants and European troops. Drastic and disruptive sanitary measures led to a conflict between the interests of competing conceptions of public health and those of commerce, civil liberties, and popular culture. This book also examines the effort undertaken by the colonizer to make Senegal a healthy colony and Saint-Louis the healthiest port-city/capital through better hygiene, building codes, vector control, and the construction of waterworks and a sewerage system. The author offers insight into the urban processes and daily life in a colonial city during the formative years of the French empire in West Africa." -- [Publisher-supplied data]
  • Lower extremities: miscellaneous diseases -- Aortic and upper extremity arterial disease -- Carotid artery occlusive disease -- Aneurysmal disease -- Non-atherosclerotic disorders -- Arterial and venous visceral disease -- Venous diseases -- Limb swelling -- Vasospastic and vasculitic diseases -- Environmental diseases -- Limb ulcerations.
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    v. 1. Locomotor system / by Werner Platzer -- v. 2. Internal organs / by Helmut Leonhardt -- v. 3. Nervous system and sensory organs / Werner Kahle.
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    v. 1. Locomotor system / by Werner Platzer -- v.2: Internal organs / Helga Fritsch and Wolfgang Kuehnel. -- v. 3. Nervous system and sensory organs / by Werner Kahle, Michael Frotscher.
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  • Basics -- Chemistry -- Physical Chemistry -- Biomolecules -- Carbohydrates -- Lipids -- Amino acids -- Peptides and proteins -- Nucleotides and nucleic acids -- Metabolism -- Enzymes -- Metabolic pathways -- Energy metabolism -- Carbohydrate metabolism -- Lipid metabolism -- Protein metabolism -- Nucleotide metabolism -- Porphyrin metabolism -- Cell organelles -- Basics -- Cytoskeleton -- Nucleus -- Mitochondria -- Membranes -- ER and Golgi apparatus -- Lysosomes -- Peroxisomes -- Molecular Genetics -- Overview -- Genome -- Chromatin -- Gennetic code -- Genetic engineering -- Tissues and organs -- Digestive system -- Blood -- Immune system -- Liver -- Adipose tissue -- Kidney -- Muscle -- Connective tissue -- Brain and sensory organs -- Integration of metabolism -- Nutrition -- Nutrients -- Vitamins -- Signaling systems -- Signal transduction -- Hormone systems -- Lipophilic signaling substances -- Hydrophilic signaling substances -- Growth and development -- Appendix.
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    "Arsenic intoxication is one of the important problems facing the world today, together with the contamination of drinking water. It is a matter of international importance to be able to correctly diagnose chronic arsenic poisoning and to prevent the development of cancers and circulatory disturbances and to supply arsenic-free drinking water"--Preface.
  • Cell machinery -- Cellular basis of hematopoiesis -- Growth factors -- Maturation of blood cells and their examination in peripheral blood and bone marrow -- Hypochromic anemias -- The porphyrias and iron overload -- Megaloblastic anemias -- Hemolytic anemias -- Genetic disorders of hemoglobin -- Benign disorders of phagocytes -- Benign disorders of lymphocytes -- Acute leukemias -- Chronic myeloid (myelogenous) leukemias and myelodysplastc/myeloproliferative neoplasms -- Myelodysplastic syndromes -- Myeloproliferative neoplasms -- Histiocytic disorders -- Aplastic and dyserythropoietic anemias -- Chronic lymphoid leukemias -- Non-Hodgkin lymphomas: mature B-cell neoplasms: written with professor Elias Campo -- Peripheral T-cell disorders -- Hodgkin lymphoma -- Myeloma and related conditions -- Tissue typing and stem cell treansplantation -- Vascular and platelet bleeding disorders -- The inherited and acquired coagulation disorders -- Thrombosis -- Secondary anemia and bone marrow in nonhematopoietic disorders -- Parasitic disorders -- Blood transfusion.
  • "This book is the first pictorial histopathology atlas with annotations on tuberculosis. The book's drug discovery and animal model perspective makes it applicative rather than academic. Each section will cover the manifestations of induced or acquired pulmonary tuberculosis in one of six animal species (models) - human, non-human primate, rabbit, guinea pig, rat, and mouse. It provides low, medium, and high power microscopy views of lung tissue in color."--Excerpt from publisher notes.
  • Anomalous systemic venous return -- Secundum atrial septal defect -- Tricuspid valve anomalies -- Endocardial cushion defects -- Ventricular septal defects -- Fontan operation -- Pulmonary stenosis -- Pulmonary atresia and intact ventricular septum -- Tetralogy of fallot -- Double outlet ventricles -- Pulmonary atresia with ventricular septal defect -- Pulmonary venous anomalies -- Left atrial obstructive lesions -- Valvular stenosis -- d-Transposition of the great arteries -- l-Transposition of the great arteries -- Truncus arteriosus -- Aortic root anomalies -- Interrupted aortic arch -- Coarctation of the aorta -- Patent ductus arteriosus -- Vascular ring and vascular sling -- Miscellaneous.
  • Examination and Interactions with Aesthetic Patients / William PD Chen, Jemshed A Khan -- Eyelid Anatomy / William PD Chen, Jemshed A Khan -- Pre-operative Preparation, Anesthesia and Postoperative Considerations / William PD Chen, Jemshed A Khan -- Endoscopic-assisted Eyebrow Surgery / Clinton J McCord -- Upper Blepharoplasty / William PD Chen -- Direct Browlift, Internal Browpexy, Browplasty / William PD Chen -- Asian Blepharoplasty of the Upper Eyelid / William PD Chen -- Lower Blepharoplasty and Primary Cheeklift / Clinton J McCord -- Avoidance of Complications with Lower Blepharoplasty Cheeklift / Clinton J McCord -- CO2 Laser Transconjunctival Blepharoplasty and Fat Repositioning / Jemshed A Khan -- Transconjunctival Laser Blepharoplasty of Lower Eyelid / Jemshed A Khan -- Ptosis (Blepharoptosis) / Jemshed A Khan -- Cosmetic Botulinum Neurotoxin Application / Jemshed A Khan, Michael S. McCracken -- Ablative and Fractionated Laser Skin Resurfacing / Jemshed A Khan -- Management of the Upper Eyelid Crease: Advanced Techniques / William PD Chen -- Advanced Concept of A Glide Zone as it Relates to Upper Lid Crease, Lid Fold, and Application in Upper Blepharoplasty / William PD Chen -- Advanced Concept of Bevelled Approach in Revisional Asian Blepharoplasty: Resetting of High Crease / William PD Chen -- Botulinum Toxin and Dermal Filler Use in the Periorbital Areas / Stuart Seiff -- Hyaluronic Acid Filler Injection / Michael S. McCracken, Jemshed A Khan.
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    v. 1. The alimentary system.
  • Surgery of the anterior mandible -- Surgery of the posterior mandible -- Implants for the maxillary edentulous patient -- Surgery of the partially edentulous maxilla -- Zygomaticus implants and angled implants for the edentulous maxilla -- Maxillary sinus grafting -- Techniques for grafting and implant placement for the extraction site -- Immediate provisionalization of implant restorations -- Esthetic anterior implant restorations: surgical techniques for optimal results -- Soft tissue manipulation around implants in the esthetic zone.
  • "Handy compendium of diagnosis and therapy of the major dermatologic diseases, brief and to the point. Clear presentation of complex themes and therapy principles with the aid of descriptive color plates and concise texts A multitude of images and color plates to aid visual understanding Also useful for revision, e.g. before oral examinations Visualisaton of complex contexts and techniques using actual cases Covers pathophysiology, therapy, clinical hallmarks, histology images"--Provided by publisher.
  • Learning with images and digital photography -- The essence of family medicine -- Physicial and sexual abuse -- Ophthalmology -- Ear, nose, and throat -- Oral health -- The heart and circulation -- The lungs -- Gastrointestinal -- Genitourinary -- Women's health -- Musculoskeletal problems -- Dermatology -- Podiatry -- Infectious diseases -- Endocrine -- Neurology -- Substance abuse -- Interpreting evidence-based medicine -- Guide for the use of topical and intralesional corticosteroids -- Dermoscopy.
  • This book serves as a comprehensive atlas of the developmental histology of the major organs from 15 weeks gestation to the neonatal period. Each section includes text on basic embryologic processes that influence the development of each organ and highlight major histologic features that correspond with certain developmental periods. In addition, there are many color photomicrographs at key developmental stages to assist the reader in identifying appropriate histologic changes at each developmental stage. This book will be of great value to students of embryology, pathology residents and fellows, and attending pathologists who perform fetal autopsies.
  • Introduction -- Chronology -- Fundamentals -- Prologue -- Molecular basis of genetics -- Analysis of DNA -- Variability of DNA -- Processing of DNA -- Eukaryotic cells -- Formal genetics -- Chromosomes -- Regulation of gene function -- Epigenetic modifications -- Genetic signal pathways -- Genes in embryonic development -- Genomics -- Genetics and medicine -- Imbalanced homeostasis -- Metabolic disorders -- Immune system -- Origins of cancer -- Impaired cell and tissue structure -- Hemoglobin disorders -- Sex determination and differentiation -- Atypical patternns of genetic transmission -- Sensory perception -- Karyotype-phenotype relationnship -- A grief guide to genetic diagnosis -- Morbid anatomy of the human genome - chromosomal locations - alphabetic list -- Appendix -- Supplementary data.
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    v. 1. Vaginal operations, 1978 -- v. 2. Abdominal operations for benign conditions, 1978 -- v. 3. Operations for malignant disease, 1979 -- v. 4. Surgery of the vulva and lower genital tract, 1980 -- v. 5. Infertility surgery -- v. 6. Surgery of conditions complicating pregnancy.
  • 1. Nose and paranasal sinus -- 2. Larynx and trachea -- 3. Thyroid -- 4. Salivary glands -- 5. Repair of external nose defects -- 6. Axial and free flaps -- 7. Mandible -- 8. Lips and face -- 9. Temporal bone malignancy -- 10. Head and neck -- References -- Index.
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    The cell -- Epithelium and glands -- Connective tissue -- Cartilage and bone -- Blood and hemopoiesis -- Muscle -- Nervous tissue -- Circulatory system -- Lymphoid tissue -- Endocrine system -- Integument -- Respiratory system -- Digestive system I: oral region -- Digestive system II: alimentary canal -- Digestive system III: digestive glands -- Urinary system -- Female reproductive system -- Male reproductive system -- Special senses.
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  • The body -- The Cell -- Tissues -- General features of the skeleton -- General features of the muscles -- Anatomical terms and their Latin equivalents -- Trunk -- Anatomical terms and their Latin equivalents -- Upper Limb -- Bones, ligaments and joints -- Muscles, fascias, and special features -- Anatomical terms and their Latin equivalents -- Lower Limb -- Bones, ligaments, joints -- Muscles, fascias, and special features -- Anatomical terms and their Latin equivalents -- Head and Neck -- Skull -- Muscles and fascias -- Anatomical terms and their Latin equivalents -- Topography of peripheral nerves and vessels -- Head and neck -- Upper limb -- Trunk -- Lower limb -- Anatomical terms and their Latin equivalents.
  • Vescera at a glance -- Cardiovascular system -- Respiratory system -- Alimentary system -- Urinary system -- Male genital system -- Female genital system -- Pregnancy and human development -- Endocrine system -- Blood and lymphatic systems -- The integument.
  • Basic elements of the nervous system -- Spinal cord and spinal nerves -- Brain stem and cranial nerves -- Cerebellum -- Diencephalon -- Telencephalon -- Cerebrovascular and ventricular sytstems -- Autonomic nervous system -- Functional systems -- The eye -- The ear.
  • Ocular trauma / Daniele Veritti ... [et al.] -- Eyelids and lacrimal system / Christopher I. Zoumalan ... [et al.] -- Orbital infections, inflammation, and neoplasms / Praveen Saluja ... [et al.] -- External diseases / Guillermo Simón-Castellví ... [et al.] -- Cornea / W. Barry Lee and Ivan R. Schwab -- Intraocular inflammation / Soosan Jacob ... [et al.] -- Lens and cataract / Athiya Agarwal, Soosan Jacob, and Amar Agarwal -- Glaucoma / Soosan Jacob and Amar Agarwal -- Medical retina / Mandeep Lamba, Soosan Jacob, and Amar Agarwal -- Surgical retina / Clement K. Chan and Dariusz G. Tarasewicz -- Ocular neoplasms / Soosan Jacob, Santosh Hanovar, and Amar Agarwal -- Strabismus / Federico G. Velez, Noa Ela-Dalman, and Arthur L. Rosenbaum -- Neuro-ophthalmology / Soosan Jacob and Amar Agarwal -- Ophthalmic pharmacology / James M. Hill ... [et al.] -- Ocular manifestations of systemic disease / Soosan Jacob and Amar Agarwal -- Contact lenses / Kenneth M. Daniels -- Ophthalmic instruments and diagnostic tests / Samuel Boyd and Amar Agarwal -- Ophthalmic office procedures / Samuel Boyd -- Refractive surgery / David R. Hardten ... [et al.].
  • Fundamentals -- Temperature, energy -- Blood -- Respiration, acid-base balance -- Kidney, salt and water balance -- Stomach, intestines, liver -- Heart and circulation -- Metabolism -- Hormones -- Neuromuscular and sensory systems.
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    Fundamentals and cell physiology -- Nerve and muscle, physical work -- Autonomic nervous system (ANS) -- Blood -- Respiration -- Acid-base homeostasis -- Kidneys, salt, and water balance -- Cardiovascular system -- Thermal balance and thermoregulation -- Nutrition and digestion -- Hormones and reproduction -- Central nervous system and senses.
  • Fundamentals and cell physiology -- Nerve and muscle, physical work -- Autonomic nervous system (ANS) -- Blood -- Respiration -- Acid-base homeostasis -- Kidneys, salt, and water balance -- Cardiovascular system -- Thermal balance and thermoregulation -- Nutrition and digestion -- Hormones and reproduction -- Central nervous system and senses.
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  • Strabismus can be devastating to patients, yet often difficult to treat, even for the most seasoned veteran. The Atlas of Strabismus Surgery, Fourth Edition clearly and succinctly shares with the reader strategies and surgical techniques to improve the care of patients, starting with the simple basics and progressing to more complicated procedures. Updated from the successful third edition, the atlas is designed for resident ophthalmologists and experienced strabismologists alike. Complete with hundreds of color illustrations, as well as updated surgical videos not found in the previous edition, The Atlas of Strabismus Surgery, Fourth Edition covers the management of a wide range of strabismus disorders, from the relatively simple horizontal strabismus, to the complex cyclo-vertical deviations.
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  • This color atlas is a detailed guide on how to perform open, endoscopic, and robotic thyroidectomy techniques safely and effectively. Each chapter offers step-by-step descriptions of essential surgical procedures and techniques. Relevant information is included on surgical anatomy, and clear guidance is provided on preoperative set-up, draping, instrumentation, and complications and their treatment. The description of endoscopic thyroidectomy techniques focuses on the bilateral axillo-breast approach (BABA), while in the case of robotic thyroidectomy both BABA and the bilateral axillo-postauricular approach are described. In each case, the evidence supporting the technique is carefully examined. In the closing chapter, the role of new energy sources in thyroid surgery is discussed. The lucid text is supported by more than 200 full-color illustrations clarifying surgical anatomy, instrumentation, and procedures, and surgical video clips are also available to readers via a website. This atlas will be invaluable in enabling surgeons to achieve optimal outcomes when performing thyroid surgery.
  • This pocket guide helps you to grasp the connection between three-dimensional organ systems and their two-dimensional representation in ultrasound imaging. Through dynamic illustrations and clarifying text, it allows you to: recognize, name, and confidently locate all organs, landmarks, and anatomical details of the abdomen; examine all standard planes, including transverse and longitudinal scans for regions of sonographic interest (including the thyroid gland); understand topographic relationships of organs and structures in all three spatial planes. This text is ideal for the beginner, providing a rapid orientation to all key topics. It includes: over 250 fully labeled image quartets, each showing: the preferred location of the transducer on the body; the resulting image; a labeled drawing of the image, keyed to anatomic structures; and a small 3-D drawing showing the location of the scanning plane in the organ. Body markers with information on transducer handling and positioning for each sonogra; over 250 rules of thumb and key concepts; all relevant landmarks, measurable parameters, and normal values.
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  • Physical and technical principles of color Doppler sonography / R. Kubale and G. Hetzel -- Safety aspects of Doppler and color Doppler sonography / H.-D. Rott -- Uterine blood flow in fertile and infertile women / S. Kupesic and A. Kurjak -- Uterine causes of infertility / S. Kupesic and A. Kurjak -- Changes in uterine and ovarian perfusion with the onset of menopause / A. Kurjak and S. Kupesic -- Color Doppler sonography for the optimization of assisted reproduction / D. Grab and K. Sterzik -- Pulsed Doppler and color duplex sonography in the assessment of tubal patency / B. Hüneke ... [et al.] -- Abnormalities of corpus iuteum function / S. Kupesic, A. Kurjak, T. Zodan -- Interventional ultrasound in reproductive medicine / S. Kupesic, A. Kurjak, and A.K. Ertan -- Doppler ultrasound examinations from folliculogenesis to early pregnancy / S. Kupesic, A. Kurjak, and W. Schmidt -- Evaluation of early placentation and the embryonic circulation with Doppler ultrasound / A. Kurjak and S. Kupesic -- Color Doppler sonography in ectopic pregnancy / H.J. Voigt. Physiology of Doppler flow in maternal vessels during pregnancy / T. Golaszewski, J. Deutinger, and G. Bernaschek -- Color Doppler sonography of the uterine arteries in early pregnancy to screen for preeclampsia and uteroplacental insufficiency / A. Funk -- Normal fetomaternal Doppler indices in the second and third trimesters of pregnancy / A.K. Ertan ... [et al.] -- Venous Doppler sonography / F. Bahlmann -- Color Doppler sonography in the diagnosis of Nuchal cord / A.K. Ertan, H.J. Hendrik, W. Schmidt -- Chronic placental insufficiency / H.J. Hendrik, A.K. Ertan, and W. Schmidt -- Severely abnormal Doppler findings and perinatal abnormalities / A.K. Ertan, H.J. Hendrik, W. Schmidt -- Fetal Doppler findings in late pregnancy / K. Vetter -- Intrapartum Fetal Heart Rate changes and Doppler sonography / E. Weiss -- Color Doppler ultrasound in fetal echocardiography / A. Lindinger -- Use of color Doppler in echocardiography / U. Gembruch -- Structure of the human placenta and pathomorphological changes in placental insufficiency / K.R. Reitnauer. Morphological and morphometric studies of the placenta with Doppler abnormalities of the fetal umbilical arteries / T. Hitschold -- Sonographic and Doppler sonographic examination of uterine anomalies / S. Kupesic and A. Kurjak -- Doppler examination of the normal endometrium and benign endometrial changes / S. Kupesic, A. Kurjak -- Transvaginal color Doppler and pulsed Doppler diagnosis of benign changes in the uterine myometrium / A. Kurjak, S. Kupesic -- Use of color Doppler in the evaluation of suspicious endometrial findings / M. Holländer ... [et al.] -- Malignant uterine tumors / A. Kurjak and S. Kupesic -- Blood flow changes in cervical carcinoma treated by primary chemotherapy / C. Villena-Heinsen ... [et al.] -- Color Doppler imaging of benign adnexal masses-a spectrum of findings / A. Kurjak, S. Kupesic, and A.K. Ertan -- Malignant adnexal tumors / A. Kurjak, S. Kupesic, and A.K. Ertan -- Three-dimensional power Doppler sonography in evaluating the angiogenesis of ovarian tumors / A. Kurjak, S. Kupesic, and B. Breyer -- Ovarian cancer screening / A. Kurjak ... [et al.]. General aspects of the ultrasound investigation of blood flow in breast tumors / C. Villena-Heinsen, M. Holländer, and W. Schmidt -- Color Doppler sonography in the diagnosis of breast cancer / H. Madjar -- Usefulness of the minimum resistance index in the benign-malignant discrimination of breast tumors / C. Villena-Heinsen ... [et al.] -- Effect of menopausal status and hormone replacement on therapy resistance indices and blood flow velocities in breast tumors / C. Villena-Heinsen, I. Tossounidis, and W. Schmidt -- Benign-malignant tumor discrimination and prognostic evaluation of breast tumors with color Doppler sonography / C. Villena-Heinsen ... [et al.].
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    1. Introduction to histology and basic histological techniques - 2. Cytoplasm -- 3. Nucleus -- 4. Extracellular matrix -- 5. Epithelium and glands -- 6. Connective tissue -- 7. Cartilage and bone -- 8. Muscle -- 9. Nervous tissue -- 10. Blood and hemopoiesis -- 11. Circulatory system -- 12. Lymphoid (immune) system -- 13. Endocrine system -- 14. Integument -- 15. Respiratory system -- 16. Digestive system: oral cavity -- 17. Digestive system: alimentary canal -- 18. Digestive system: glands -- 19. Urinary system -- 20. Female reproductive system -- 21. Male reproductive system -- 22. Special senses.
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    1. Structure and function of the skin -- 2. Evaluation of children with skin disease -- 3. Acne -- 4. Dermatitis -- 5. Bacterial infections (Pyodermas) and spirochetal infections of the skin -- 6. Fungal and yeast infections of the skin -- 7. Infestations -- 8. Viral infections -- 9. Papulosquamous disorders -- 10. Sun sensitivity -- 11. Bullous diseases and mucocutaneous syndromes -- 12. Skin cysts and nodules -- 13. Vascular lesions -- 14. Vascular reactions: urticaria, erythemas, and purpuras -- 15. Hair disorders -- 16. Nail disorders -- 17. Disorders of pigmentation: the white lesions and the brown lesions -- 18. Immobile and hypermobile skin -- 19. Genodermatoses -- 20. Drug eruptions -- 21. Skin diseases in newborns -- 22. Dermatopharmacology and topical formulary.
  • Colorectal cancer 2010
    Epidemiology and risk factors of colorectal cancer / Kathryn M. Chu -- Presentation and initial evaluation of colorectal cancer / Susan Tsai and Susan L. Gearhart -- Hereditary colorectal cancer and polyp syndromes / Francis M. Giardiello -- Genetic screening / Cheryl J. Pendergrass -- Behavior and dietary modification in the prevention of colon cancer / Stephanie Downing, Emmanouil P. Pappou, and Nita Ahuja -- Chemoprevention of colorectal cancer / Melissa A. Munsell and Francis M. Giardiello -- Fecal occult blood test / Michel A. Kafrouni and John H. Kwon -- Colonoscopy and flexible sigmoidoscopy in colorectal cancer screening and -- Surveillance / Michelle N. Zikusoka and John H. Kwon -- Stool and blood sampling for early detection of colorectal cancer / Jason K. Sicklick and Nita Ahuja -- Radiologic techniques : virtual colonoscopy / Karen M. Horton -- Preoperative evaluation / Jerry Stonemetz, Nicole A. Phillips, and Susan L. Gearhart -- Limited resection : indications, techniques, and outcomes of transanal excision and -- Transanal endoscopic microsurgery / Elizabeth C. Wick -- Minimally invasive techniques : indications, techniques, and outcomes / Susan L. Gearhart -- Endoscopic techniques in colorectal neoplasia / Eun i. Shin and Samuel A. Giday -- Open surgical techniques in colorectal cancer / Vanita Ahuja -- Systemic therapy for colon cancer / Khaled El-Shami, Sujatha Nallapareddy, and Wells Messersmith -- Radiation therapy for colorectal adenocarcinoma : external beam and intraoperative -- Radiation therapy / Joseph M. Herman and Timothy M. Pawlik -- Surveillance and follow-up / Matthew T. Hueman and Nita Ahuja -- Clinical trials : why participate? / Jamila Mwidau and David Chang -- Vaccines and immunotherapy / Ajay Jain and Richard Schulick -- Genetic profiling in colorectal cancer / Debashish Bose and Nita Ahuja -- Coping with colorectal cancer / Eden R. Stotsky.
  • Colorectal cancer 2009
  • Molecular biology of colon cancer / William M. Grady -- Chemoprevention of colorectal cancer / Yu-Ning Wong ...[et al.] -- Colorectal cancer screening and surveillance / Arnold J. Markowitz -- Cytotoxic chemotherapy for metastatic colorectal cancer / M. Wasif Saif, Richard Kim, and Edward Chu -- Integration of antiangiogenic strategies in colorectal cancer treatment / John M. Strother and Charles D. Blanke -- The role of EGFR inhibition in colorectal cancer / Nabeel Shalan and Paulo M. Hoff -- Second-line strategies in the treatment of patients with metastatic colorectal cancer / Anthony B. El-Khoueiry and Heinz-Josef Lenz -- Adjuvant chemotherapy for colon cancer / Bert H. O'Neil ... [et al.] -- Management of locally advanced rectal cancer / Yu Jo Chua and David Cunningham -- Rationale for adjuvant and neoadjuvant chemotherapy in the resection of liver metastases / Axel Grothey and Steven A. Alberts -- Percutaneous radiofrequency ablation in the management of patients with colorectal cancer / Karen Brown -- Colorectal cancer imaging / Sean D. Curran and Laurence H. Schwartz -- Nursing issues in colorectal cancer chemotherapy / Ellen Hollywood and Deborah Semple -- Pain management in the colorectal cancer patient / Vivek Tim Malhotra -- Novel agents and new paradigms for colorectal cancer / Chris Takimoto and Russell Kruzelock.
  • As the population ages, clinicians are facing an increasing number of elderly patients with colorectal cancer. Disease management in these patients poses a unique challenge as they have more comorbidities and lower functional reserves. In addition, the treatment goals may differ from those in younger patients. Appropriate management of elderly patients demands a greater understanding of not only the physiological changes but also issues related to the delivery of holistic care. This book discusses in depth the different aspects of management of colorectal cancer in the elderly. After the provision of pertinent background information on the normal physiology of aging, screening and diagnosis are discussed. Subsequent chapters focus on a range of issues associated with the surgical and perioperative care of these patients and with adjuvant treatment and palliative care. Each chapter provides helpful take-home messages in bullet point form, and numerous informative figures and tables are also included. The authors are surgeons, physicians, anesthetists, geriatricians, oncologists, and allied health professionals with extensive experience in the field.This book discusses in depth the different aspects of management of colorectal cancer in the elderly. After the provision of pertinent background information on the normal physiology of aging, screening and diagnosis are discussed. Subsequent chapters focus on a range of issues associated with the surgical and perioperative care of these patients and with adjuvant treatment and palliative care. Each chapter provides helpful take-home messages in bullet point form, and numerous informative figures and tables are also included. The authors are surgeons, physicians, anesthetists, geriatricians, oncologists, and allied health professionals with extensive experience in the field.
  • Colorectal cancer pathways / Petr Protiva -- Risk factors and screening for colorectal cancer / Joseph C. Anderson -- Hereditary adenomatous colorectal cancer syndromes / Maqsood Khan and Carol A Burke -- Screening and surveillance guidelines / Robert J. Chehade and Douglas J. Robertson -- Barriers to colorectal cancer screening : patient, physician, and system factors / Catherine R. Messina -- Screening for colorectal cancer using colonoscopy / Douglas K. Rex -- New colonoscopic technologies for colorectal cancer screening / Douglas K. Rex -- Screening for CRC using CT colonography / Brooks D. Cash -- Noninvasive screening tests / Nabil Fayad and Thomas F. Imperiale -- Removal of difficult colon polyps / Jerome Waye -- Screening for colorectal cancer in the elderly / Charles J. Kahi -- Chemoprevention / Jeffrey Singerman and Petr Protiva.
  • Overview of Colorectal Cancer / Joseph C. Anderson -- Colorectal Cancer Screening Tests and Recommendations / Don C. Rockey -- CTC Background and Development / Darren Boone -- Indications and Evidence for CTC / Elizabeth G. McFarland -- Performance and Interpretation of CTC / Peter D. Poullos -- Integration of CTC into a CRC Screening Program / Steven Carpenter -- CTC Controversies (Radiation Exposure, Extracolonic Findings, Cost-Effectiveness) / Andrea Laghi, Franco Iafrate -- CTC Pitfalls/Limitations / Donald W. Jensen, Duncan Barlow -- Future Directions/Innovations with CTC (Prepless CTC, Alternative Displays, Computer-Aided Detection) / Farid Dahi, Abraham H. Dachman.
  • Colorectal surgery 2013
    Written for the general surgeon who is called upon to manage diseases and disorders of the large bowel, rectum, and anus, this reference provides advanced, expert guidance on how to avoid complications and achieve the most successful results. Visualize relevant anatomy and techniques more easily with high-quality, full-color line drawings and clinical photos throughout. Zero in on the information you need with key points boxes in every chapter that provide a quick overview of the topic at hand. Get practical, hands-on advice on managing the diseases and disorders you're most likely to encounter. Learn from acknowledged leaders in the field who excel in both academic and clinical areas.
  • Anorectal investigation / Alexis M.P. Schizas and Andrew B. Williams -- Colonoscopy and flexible sigmoidoscopy / Adam Haycock and Siwan Thomas-Gibson -- Inherited bowel cancer / Sue Clark and Andrew Latchford -- Colonic cancer / Robert J.C. Steele -- Rectal cancer / A. Zia Janjua and Brendan J. Moran -- Adjuvant therapy for colorectal cancer / Ganesh Radhakrishna and David Sebag-Montefiore -- Anal cancer / John H. Scholefield -- Diverticular disease / Des Winter -- Ulcerative colitis / Scott R. Kelley and Eric J. Dozois -- Crohn's disease / Mark W. Thompson-Fawcett and Neil J.McC. Mortensen -- Incontinence / Paul-Antoine Lehur and Mark T.C. Wong -- Functional problems and their surgical management / Nicola S. Fearnhead -- Functional problems and their medical management / Anton V. Emmanuel -- Anal fistula : evaluation and management / Peter J. Lunniss and Robin K.S. Phillips -- Minor anorectal conditions / Jit-Fong Lim and Francis Seow-Choen -- Sexually transmitted diseases and the anorectum / Lester Gottesman and Josef A. Shehebar -- Minimally invasive surgery and enhanced recovery programmes in colorectal disease / Ian Jenkins and Robin Kennedy -- Intestinal failure / Carolynne Vaizey and Janindra Warusavitarne.
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    Adenomas -- Early colorectal cancer -- Advanced colorectal cancer -- Other intestinal neoplasms -- Non-neoplastic lesions -- Technical considerations.
  • Anatomy -- Basic techniques in ophthalmic plastic surgery -- Preoperative evaluation -- Anaesthesia -- Instruments -- Entropion -- Ectropion -- Eyelash abnormalities -- Ptosis -- Blepharoplasty -- Eyelid retraction -- Evisceration, enucleation, exenteration -- Anophthalmic socket -- Eyelid reconstruction: eyelid margin closure -- Eyelid reconstruction: anterior lamella -- Eyelid reconstruction: posterior lamella -- Eyelid reconstruction: anterior and posterior lamellae combined -- Miscellaneous conditions.
  • Chapter 1: Epidemiology applied to colposcopy / Mark Schifman, Jose Jeronimo -- Chapter 2: Human papillomaviruses and mechanisms of oncogenesis / Ann Roman, Helena Spartz, Darron R. Brown -- Chapter 3: Human papillomavirus vaccine / Stanley A. Gall -- 4: Cytology -- 4.1 Terminology in cervical cytology: the Bethesda System / Diane Davis Davey -- 4.2 Conventional cytology / Peter A. Drew, Edward J. Wilkinson -- 4.3 Thin-Layer, liquid-based cytology / Juan Felix -- Chapter 5: Adjunctive testing -- 5.1 Human papillomavirus testing / Attila T. Lorincz -- 5.2 Cervical screening with In vivo and in vitro modalities: speculoscopy combined with cytology / Neal M. Lonky -- Chapter 6: Principles and technique of the colposcopic exam / Barbara S. Apgar, Georgory L. Brotzman, Mary M. Rubin -- Chapter 7: Normal transformation zone / Denis M. O'Connor -- Chapter 8: Angiogenesis of cervical neoplasia / Adolf Stafl -- Chapter 9: Abnormal transformation zone / Georgory L Brotzman, Barbara S. Apgar -- Chapter 10: Colposcopic assessment systems -- 10.1 Rubin and Barbo colposcopic assessment system / Mary M. Rubin, Dorothy M. Barbo -- 10.2 Reids colposcopic index / Richard I. Reid -- Chapter 11: Atypical squamous cells / Thomas C. Wright, Jr. -- Chapter 12: Low-grade squamous intraepithelial lesions / Alan G. Waxman -- Chapter 13: High-grade squamous intraepithelial lesions / L. Stuart Massad -- Chapter 14: Squamous cervical cancer / R. Kevin Reynolds -- Chapter 15: Cervical glandular disease: adenocarcinoma in situ and adenocarcinoma / V. Cecil Wright -- Chapter 16: Vagina: normal, premalignant, and malignant / Barbara S. Apgar, Gregory L. Brotzman -- Chapter 17: Non-neoplastic epithelial lesions of the vulva /Lynette J. Margesson -- Chapter 18: Vulvar intraepithelial neoplasia / Alex Ferenczy -- Chapter 19: External genital condyloma / Alex Ferenczy -- Chapter 20: Lower genital tract changes associated with in utero exposure to diethylstilbestrol / Raymond H. Kaufman -- Chapter 21: Colposcopy in pregnancy / David G. Weismiller -- Chapter 22: Human papillomavirus infections in adolescents / Anna-Barbara Moscicki -- Chapter 23: Anal disease / Teresa M. Darragh, J. Michael Berry, Naomi Jay. Joel M. Palefsky -- Chapter 24: Androscopy: examination of the male partner / John L. Pfenninger -- Chapter 25: Psychosocial aspects of colposcopy / Dennis J. Butler, Gregory L. Brotzman -- Chapter 26: Practical therapeutic options for treatment of cervical intraepithelial neoplasia / Mark Spitzer, Gregory L. Brotzman, Barbara S. Apgar -- Chapter 27: Colposcopy: pitfalls and tricks of the trade / Mark Spitzer.
  • Behavioral Assessment and Diagnosis of Disorders of Consciousness / Caroline Schnakers and Steve Majerus -- Prognosis of Patients with Altered State of Consciousness / Marie-Aurélie Bruno, Didier Ledoux, Audrey Vanhaudenhuyse, Olivia Gosseries and Aurore Thibaut, et al. -- Functional Imaging and Impaired Consciousness / Audrey Vanhaudenhuyse, Melanie Boly, Marie-Aurélie Bruno, Olivia Gosseries and Athena Demertzi, et al. -- Multivariate Pattern Recognition Analysis: Brain Decoding / Jessica Schrouff and Christophe L. M. Phillips -- Spectroscopy and Diffusion Tensor Imaging in Disorders of Consciousness / Jean-Flory Luaba Tshibanda, Athena Demertzi and Andrea Soddu -- Electrophysiology and Disorders of Consciousness / Quentin Noirhomme and Rémy Lehembre -- Brain-Computer Interface: A Communication Aid? / Camille Chatelle, Zulay Lugo, Quentin Noirhomme, Bettina Sorger and Dorothee Lulé -- Using Transcranial Magnetic Stimulation to Measure Cerebral Connectivity in Patients with Disorders of Consciousness / Melanie Boly, Olivia Gosseries, Marie-Aurélie Bruno, Mario Rosanova and Marcello Massimini -- Sleep in Disorders of Consciousness / Victor Cologan and Manuel Schabus -- Sensory Stimulation Program / Haibo Di and Caroline Schnakers -- Feasibility of Oral Feeding in Patients with Disorders of Consciousness / Audrey Maudoux, Ingrid Breuskin, Olivia Gosseries, Caroline Schnakers and Audrey Vanhaudenhuyse -- Pharmacological Treatments / Olivia Gosseries, Marie Thonnard and Steven Laureys -- Deep Brain Stimulation / Marie Thonnard -- The Ethics of Managing Disorders of Consciousness / Athena Demertzi, Olivia Gosseries, Marie-Aurélie Bruno, Caroline Schnakers and Audrey Vanhaudenhuyse, et al. -- Future Perspectives of Clinical Coma Science / Steven Laureys and Caroline Schnakers.
  • 1. The Combat Environment: Preparation for Deployment -- 2. Echelons of Combat Casualty Care and Associated Imaging Resources -- 3. Blast and Ballistics: Types, Background, Terminology -- 4. Introduction to Imaging of Penetrating/Perforating Blast and Ballistic Injuries -- 5. Significant Medical Advances on the Battlefield and the Changing Roles of Imaging -- 6. Imaging Thresholds of Salvageability of Life, Limb, and Eyesight -- 7. Imaging Traumatic Brain Injury On and Off the Battlefield -- 8. Chest Imaging in a Battlefield Hospital -- 9. Abdomen and Pelvis Imaging in Iraq -- 10. Skeletal Trauma in Iraq.
  • "Presents recent research developments to aid fighting fungal infections The currently available means of combating fungal infections are still weak and clumsy. The application of fungal genomics offers an unparalleled opportunity to develop novel antifungal drugs. Interestingly, several novel antifungal drug targets have already been identified and validated. However, it is too early to expect any novel antifungal drug as drug discovery programs are still in their infancy. In addition to classical and genomic approaches to drug discovery, traditional knowledge derived from natural products and phytomedicine can provide a multitude of alternative modes of combating fungal infection. This book comprises 20 chapters on various aspects pertaining to fungal diseases in human and animals, their reservoir, fungal pathogenesis, their management and recent advances in their treatment. Issues of antifungal drug toxicity, especially nephrotoxicity, are also discussed. The development of resistance in fungal pathogens, including multidrug resistance and its mechanism, is dealt with in two chapters. Diverse diagnostic approaches to fungal infections are also reviewed. The combinational drug strategies used in combating invasive fungal infections are addressed in detail. The management of pulmonary mycoses in stem cell transplantation is also given special focus. Novel antifungal drugs (synthetic and herbal), fungal vaccines, and metabolic pathways as drug targets are discussed in detail in three different chapters. Subsequently the roles of innate immunity, cytokine therapy and immunomodulators in the treatment of fungal infections are elaborated upon. As novel drug delivery systems have a great potential for modifying the pharmacokinetics of medications, the last chapter takes this fact into consideration in its examination of state-of-the-art delivery systems in controlling fungal infections."--Publisher's website.
  • Targeting of the EGFR as a modulator of cancer chemotherapy / Jose Baselga -- Cyclin dependent kinase inhibitors in combination chemotherapy / Manish A. Shah and Gary K. Schwartz -- Development of protein kinase C and cyclin-dependent kinase inhibitors as potentiators of cytotoxic drug action in leukemia / Steven Grant -- Carboxyamidotriazole, an inhibitor of nonvoltage operated calcium entry : single agent and combination therapy for ovarian carcinoma / Chad M. Michener and Elise C. Kohn -- Targeted alpha particle therapy : a rational approach to drug development in hematologic diseases and solid tumors / John M. Burke, David A. Scheinberg, and Joseph G. Jurcic -- Pharmacologic modulation of fluoropyrimidines : building upon the lessons of the past / Owen A. O'Connor -- Development of inhibitors of HER2 with taxanes : new directions in breast cancer therapy / Shanu Modi, Monica N. Fornier, and Andrew D. Seidman -- Targeting nf-b to increase the activity of cisplatin in solid tumors / Don S. Dizon ... [et al.] -- Combinations of chemotherapy and G3139, an antisense BCL-2 oligonucleotide / Luba Benimetskaya, Sridhar Nami, and C. A. Stein -- Use of animal models to evaluate signal transduction inhibitors as modulators of cytotoxic therapy / Beverly A. Teicher.
  • Overview of combination products -- Ensuring successful combination product development -- Overview of FDA and other regulatory agency expectations -- Resource requirements -- Manufacturing of combination products -- Challenges and pitfalls to avoid with combination products -- Postlaunch compliance requirements -- Agency audits and challenges.
  • Comprising contributions from leading lipidologists from around the world, this book presents the latest and most comprehensive knowledge on the different options for combination therapy of dyslipidemia, and includes discussion of future therapies that are currently in late stages of clinical evaluation. Dyslipidemia is a leading cause of cardiovascular morbidity and mortality and most patients with this condition fail to achieve adequate control of their serum lipid levels with monotherapy. However, recent US and European guideline recommendations, based on randomized, controlled trials, fail to discuss combination therapy options for patients with dyslipidemia. Statins remain the mainstay of drug therapy for hyperlipidemia and chapters in this book specifically examine the role of add-on therapy with different agents modulating the different lipid fractions in the blood, e.g. bile acid sequestrants, fibric acid derivatives (fibrates), omega-3 fatty acids (fish oils), inhibitors of Niemann-Pick C1 like 1 (NPC1L1) protein, cholesteryl ester transfer protein (CETP), apolipoprotein B-100 and microsomal triglyceride transfer protein (MTP), and the emerging proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors. There is additional discussion of the role of non-drug therapy options such as nutraceuticals, functional foods and lipoprotein apheresis. The book also discusses the combination of antihypertensive drugs with lipid-lowering drugs in the management of cardiovascular risk in patents with dyslipidemia.
  • For over 30 years, the stepped care approach has been used in the management and treatment of hypertension. This approach advocates the use of initial monotherapy to reach the desired blood pressure, and the subsequent use of additional drugs with complementary modes of action, until the target BP is achieved. However, current control rates for hypertension suggest that such an approach may be outdated and no longer effective in the management of hypertension. Clinical trials have shown that more than 50% of patients require a combination of drug therapies to achieve their target BP. Some proponents of combination therapy have argued that the risk of adverse side effects and non-compliance will be lower than that compared to monotherapy, which initially requires higher doses to be administered to be effective. Consequently, there have been increasing calls of the necessity for a much more combined approach in the treatment of hypertension. Adding to this, Combination Therapy in Hypertension will cover current control rates of blood pressure worldwide, the benefits of monotherapy and combination therapy, examine the effectiveness, risk of adverse effects, compliance, and cost of the available therapies and will also include information on relevant outcome studies.
  • Combinatorial chemistry. Part [A]-B pt. [A]-B 1996, 2003.
    pt. B, 2003 ScienceDirect
  • In this fourth edition of Combined Scintigraphic and Radiographic Diagnosis of Bone and Joint Diseases, the text has been thoroughly amended, updated, and partially rearranged to reflect the latest advances. In addition to discussing the role of pinhole imaging in the range of disorders previously covered, the new edition pays detailed attention to the novel diagnostic use of gamma correction pinhole bone scan in a broad spectrum of skeletal disorders, including physical, traumatic, and sports injuries, infectious and non-infectious bone diseases, benign and malignant bone tumors, and soft tissue diseases. A large number of state of the art pinhole scans and corroborative CT, MRI, and/or ultrasound images are presented side by side. The book has been enlarged to encompass various new topics, including occult fractures; cervical sprain and whiplash trauma; bone marrow edema; microfractures of trabeculae; evident, gaping, and stress fractures; and differential diagnosis. This new edition will be essential reading for practitioners and researchers in not only nuclear medicine but also radiology, orthopedic surgery, and pathology.
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    The problem -- Demand for a surgical/medical workforce -- Surgical supply : residents, the future surgeons -- Constraints to supply : pertinent issues -- Calculating physician supply : the model : assumptions, relevant parameters, and the algorithm -- Orthopedic surgery -- Cardiothoracic surgery -- Otolaryngology -- Obstetrics and gynecology -- General surgery -- Neurosurgery -- Urology -- The last hurdle : the Balanced Budget Act of 1997 and graduate medical education funding -- Is there a solution? : numerical projections, and improving physicians' productivity -- Challenges and consequences.
  • Common cold 2009
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    Generalized disorders -- Respiratory disorders -- Cardiovascular disorders -- Gastrointestinal disorders -- Renal disorders -- Acid-base and electrolyte disorders -- Hematologic disorders -- Neurologic disorders -- Endocrine disorders -- Skin disorders -- Musculoskeletal disorders.
  • 1.Introduction -- 2.The Cervical Spine -- 3.The Shoulder -- 4.The Elbow -- 5.The Hand and Wrist -- 6.The Fingers -- 7.The Lumbosacral Spine -- 8.The Hip -- 9.The Knee -- 10.The Ankle -- 11.The Foot -- 12.Common Pediatric Musculoskeletal Problems -- 13.The Acutely Painful, Swollen Joint -- 14.Musculoskeletal Radiology -- 15.Splinting and Soft Tissue Issues -- 16.Pre-Participation Evaluation -- Appendix -- Index.
  • What is dementia? -- Signposts : what to look for and when to seek help -- Finding help -- Preparing for a visit to the doctor -- Making the most of the doctor's visit -- The seven common senses of dementia care -- Caring for the caregiver -- Dementia medications -- Alternative therapies in dementia -- Alcohol and other substances -- Mood issues in dementia -- Psychosis -- Dealing with problem behaviors in dementia -- Legal and financial matters -- Selecting level of care -- Looking ahead : the later stages.
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    An orientation -- Basics of quality improvement -- Advance care planning -- Preventing, assessing, and treating pain -- Assuring comfort -- Caring for caregivers -- Continuity and transfers -- Chronic care: heart and lung failure -- Nursing home quality: pressure ulcers -- Improving care for people with advanced dementia and their families -- Improving intensive care units -- Building a palliative care program -- Hospice program quality -- End-of-life care, spiritual support, and bereavement -- Beyond quality improvement: policy improvement.
  • Introduction & basics -- Topics in hypothesis testing -- The data set TRIAL -- The one-sample t-test -- The two-sample t-test -- One-way ANOVA -- Two-way ANOVA -- Repeated measures analysis -- The crossover design -- Linear regression -- Analysis of covariance -- The Wilcoxon signed-rank test -- The Wilcoxon rank-sum test -- The Kruskal-Wallis test -- The binomial test -- The Chi-square test -- Fisher's exact test -- McNemar's test -- The Cochran-Mantel-Haenszel test -- Logistic regression -- The log-rank test -- The Cox proportional hazards model -- Exercises.
  • 1. Assessing preoperative cardiac risk in patient undergoing non-cardiac surgery -- 2. Management of preoperative bleeding disorders, intraoperative coagulopathy -- 3. Preoperative nutritional assessment/intervention -- 4. Transfusion reactions -- 5. Asymptomatic carotid bruits -- 6. General operating room precautions -- Section 2: Trauma -- 7. Initial assessment & resuscitation of the trauma patient -- 8. Head trauma -- 9. Management of the difficult airway -- 10. Penetrating neck trauma -- 11. Penetrating chest trauma -- 12. Penetrating abdominal trauma -- 13. Blunt abdominal trauma -- 14. Pelvic fractures -- 15. Traumatic hematuria -- 16. Knee pain -- 17. Shoulder pain -- 18. Hip fractures -- 19. Extremity fractures -- 20. Burns -- Section 3: Vascular problems -- 21. Chronic lower extremity ischemia -- 22. The acute cold leg -- 23. Myocardial infarction -- 24. Abdominal aortic aneurysm -- Section 4: Endocrine disorders -- 25. Solitary thyroid nodule and cancer -- 26. Cushing's Syndrome -- 27. Hyperthyroidism -- 28. Hypercalcemia -- 29. Insulinoma -- 30. Zollinger Ellison Syndrome -- 31. Surgical hypertension -- Section 5: Abdomen -- 32. Acute pancreatitis -- 33. Chronic pancreatitis -- 34. Small bowel obstruction -- 35. Ischemic bowel -- 36. Crohn's disease -- 37. Ulcerative colitis -- 38. Appendicitis -- 39. Acute abdomen -- 40. Diverticulitis -- 41. Large bowel obstruction -- 42. Colon cancer -- 43. Rectal cancer -- 44. Anal cancer -- 45. Anorectal pain -- 46. Hematemesis -- 47. Lower gastrointestinal hemorrhage -- 48. Cholelithiasis, incidental and symptomatic -- 49. Jaundice -- 50. Liver mass -- 51. Peptic ulcer disease -- 52. Dysphagia -- 53. Rectal bleeding -- 54. Inguinal hernia -- 55. Portal hypertension -- 56. Gastroesophageal reflux -- 57. Carcinoid tumors --- 58. Indications for renal transplantation -- 59. Indications, evaluation and allocation for liver transplantation --- 60. Melanoma -- Section 6: Pediatrics -- 61. Hypertrophic pyloric stenosis -- 62. Jaundice in the pediatric patient -- 63. Pediatric abdominal masses -- 64. Esophageal atresia/tracheoesophageal fistula -- 65. Intussusception -- 66. Hirschsprung's disease -- 67. Necrotizing enterocolitis -- Section 7: Urology -- 68. Hematuria -- 69. Nephrolithiasis -- 70. Prostatism -- 71. Testicular masses -- 72. Urinary tract infections -- 73. Painful scrotum -- Section 8: Gynecology -- 74. Acute pelvic pain -- 75. Evaluation of the adnexal mass -- 76. Pelvic inflammatory diseases -- Section 9: Thoracic problems -- 77. Solitary pulmonary nodules -- 78. Pleural effusions -- 79. Acute respiratory distress syndrome -- 80. Nosocomial pneumonia -- Section 10: Breast disorders -- 81. Palpable breast mass -- 82. Abnormal mammogram -- 83. Invasive breast cancer -- 84. Nipple discharge -- 85. Breast pain -- 86. Ductal carcinoma in-situ -- Section 11: Head and neck disorders -- 87. Parotid mass -- 88. Evaluation of suspicious neck mass -- Section 12: On-call crises -- 89. Epistaxis -- 90. Diabetic ketoacidosis -- 91. Oliguria -- 92. Postoperative fever -- 93. Hypercalcemic crisis -- 94. Postoperative chest pain -- Section 13: Critical care -- 95. Management of cardiac arrhythmias -- 96. Ventilator management -- 97. Hypoxia and pulmonary embolism -- 98. Hypotension in the postoperative patient -- Cancer screening guidelines.
  • Cardiac Clearance for Non-Cardiac Surgery -- Preoperative Evaluation of Bleeding -- Managing Patient's Medications (Diabetes, Beta Blockers, NSAIDS, Anticoagulants) -- The Carotid Bruit -- DVT Prophylaxis -- Initial Trauma Assessment and Resuscitation -- Head Trauma -- Management of the Difficult Airway -- Penetrating Neck Trauma -- Penetrating Chest Trauma -- Penetrating Abdominal Trauma -- Blunt Abdominal Trauma -- Pelvic Fractures -- Traumatic Hematuria -- Extremity Fractures -- Burns -- Chronic Lower Extremity Ischemia -- Algorithmic Approach to the Acute Cold Leg -- Myocardial Infarction -- Abdominal Aortic Aneurysm -- Dialysis Access -- Thyroid Nodules and Malignancy -- Cushing?s Syndrome -- Hyperthyroidism -- Hypercalcemia -- Insulinoma -- Gastrinoma -- Surgical Hypertension: Evaluation and Treatment -- Incidentalomas -- Upper Gastrointestinal Hemorrhage -- Dysphagia -- Esophageal Cancer -- Gastroesophageal Reflux -- Acute Pancreatitis -- Chronic Pancreatitis -- Small Bowel Obstruction -- Ulcer Disease and Helicobacter Pylori -- Ischemic Bowel -- Crohn's Disease -- Ulcerative Colitis -- Acute Appendicitis -- Diverticulitis -- Large Bowel Obstruction -- Colon Cancer -- Lower Gastrointestinal Hemorrhage -- Genetic Predisposition to Colorectal Cancer -- Rectal Cancer -- Anal Cancer -- Anorectal Pain- Rectal Bleeding -- Rectal Bleeding -- Jaundice -- Liver Mass -- Portal Hypertension -- Carcinoid Disease -- Inguinal Hernia -- Abdominal Wall Defects -- Indications for Renal Transplantation -- Indications for Liver Transplantation and Pre-transplant Evaluation -- Palpable Breast Mass -- Abnormal Mammogram -- Invasive Breast Cancer -- Nipple Discharge -- Ductal Carcinoma in Situ -- Genetic Predisposition to Breast Cancer -- Melanoma -- Solitary Pulmonary Nodules -- Evaluation of the Suspicious Neck Mass -- Hypertrophic Pyloric Stenosis -- Jaundice in the Pediatric Patient -- Pediatric Abdominal Masses -- Esophageal Atresia/Tracheoesophageal Fistula -- Intussusception -- Hirschsprung?s Disease -- Necrotizing Enterocolitis -- Hematuria -- Testicular Mass -- Painful Scrotum -- Acute Gynecologic Pelvic Pain -- Evaluation and Management of Adnexal Masses -- Pelvic Inflammatory Diseases -- Postoperative Glucose Management -- Oliguria -- Postoperative Fever -- Postoperative Chest Pain -- Necrotizing Soft Tissue Infections -- Systemic Inflammatory Response Syndrome (SIRS) and Sepsis.
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  • Commonsense reasoning 2006
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  • Addressing peers -- General public -- Decision makers.
  • 1. Revisiting Models -- Paradigm Change for Science Communication: Commercial Science Needs a Critical Public / Martin W. Bauer, p. 7-25 -- European Trends in Science Communication / Michel Claessens, p. 27-38 -- Words and Figures of the Public: the Misunderstanding in Scientific Communication / Joëlle Le Marec and Igor Babou, p. 39-54 -- Representation and Deliberation: New Perspectives on Communication Among Actors in Science and Technology Innovation / Giuseppe Pellegrini, p. 55-69 -- Medialization of Science as a Prerequisite of Its Legitimization and Political Relevance / Hans Peter Peters, Harald Heinrichs, Arlena Jung, Monika Kallfass and Imme Petersen, p. 71-92 -- On and about the Deficit Model in an Age of Free Flow / Bernard Schiele, p. 93-117 -- Towards an Analytical Framework of Science Communication Models / Brian Trench, p. 119-135 -- 2. Crossing Boundaries -- Before and After Science: Science and Technology in Pop Music, 1970-1990 / Massimiano Bucchi and Andrea Lorenzet, p. 139-150 -- The More, the Earlier, the Better: Science Communication Supports Science Education / Cheng Donghong and Shi Shunke, p. 151-163 -- Hollywood Knowledge: Communication Between Scientific and Entertainment Cultures / David A. Kirby, p. 165-180 -- Situating Science in the Social Context by Cross-Sectoral Collaboration / Jenni Metcalfe, Michelle Riedlinger and Anne Pisarski, p. 181-197-- 3. Developing Strategies -- From Science Communication to Knowledge Brokering: the Shift from 'Science Push' to 'Policy Pull' / Alex T. Bielak, Andrew Campbell, Shealagh Pope, Karl Schaefer and Louise Shaxson, p. 201-226 -- Science Advocacy: Challenging Task, Difficult Pathways / Toss Gascoigne, p. 227-241 -- The Epistemic Jumble of Sustainable Development / Yves Jeanneret, p. 243-257 -- In Search of Dialogue: Staging Science Communication in Consensus Conferences / Maja Horst, p. 259-274 -- So Where's the Theory? On the Relationship between Science Communication Practice and Research / Steve Miller, p. 275-287 -- From Democratization of Knowledge to Bridge Building between Science, Technology and Society / Lise Santerre, p. 289-300 -- Bringing Science to the Public / Jan Riise.
  • Diagnosis and staging -- Primary treatment -- Communication within the context of multidisciplinary care -- Explaining follow-up -- Progression and terminal -- Explaining research -- Complementary and alternative medicines and integrative oncology.
  • In contrast to traditional approaches of mainstream psycholinguists, the authors of 'Communicating with One Another' approach spontaneous spoken discourse as a dynamic process, rich with structures, patterns, and rules other than conventional grammar and syntax.
  • Communication disorders in a multicultural and global society / Dolores E. Battle -- African American and other Blacks with communication disorders / Dolores E. Battle -- Communication disorders in Asian and Pacific American cultures / Li-Rong Lilly Cheng -- Communication disorders in the Middle East and Arab American populations / Freda Wilson -- Communication disorders in Native American and world wide indigenous cultures / Carol Westby, Ella Inglebret -- Hispanic and Latino cultures in the United States and Latin America / Hortencia Kayser -- Multilingual speech and language development and disorders / Helen Grech, Sharynne McLeod -- Neurogenic disorders of speech, language, cognition-communication, and swallowing / Constance Dean Qualls -- Cultural diversity and fluency disorders / Tommie L. Robinson Jr. -- International and intercultural aspects of voice and voice disorders / Marla Behlau, Thomas Murray -- Multicultural aspects of hearing loss / Zenobia Bagli -- Assessment of multicultural and international clients / Toya Wyatt -- Intervention for multicultural and international clients / Priscilla Nellum-Davis, Tachelle Banks -- Multicultural and international research : past, present, and future / Constance Dean Qualls.
  • Background Theories and Main Systems of Analysis of Communication in Cognitive-Behavioral Therapy / Michela Rimondini -- Assessment Stage: Data Gathering and Structuring the Interview / Francesca Moretti -- Building the Working Alliance in Brief Psychotherapies / Hanneke De Haes -- Providing Information and Involving the Patient in the Therapeutic Process / Francesca Moretti -- Nonverbal Communication in Clinical Contexts / Lidia Del Piccolo -- Communication in Depressive States / Franco Baldini -- Interpersonal Vicious Cycles in Anxiety Disorders / Francesco Mancini -- Cognitive-Behavioral Family Interventions in Psychosis / Elizabeth Kuipers -- Learner-Centered Interactive Methods for Improving Communication Skills / Michela Rimondini -- Quantitative Methods for the Analysis of Verbal Interactions in Psychotherapy / Maria Angela Mazzi -- Qualitative Methods for the Analysis of Verbal Interactions in Psychotherapy / Svein Bergvik.
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    Defining and understanding communication -- Communicate -- Orientation and opportunity -- Mindful presence -- Family -- Openings -- Relating -- Team -- Communicating self-care needs.
  • Around the world, the number of internationally mobile medical professionals is steadily increasing, posing potential difficulties for the good communication with patients and colleagues that is vital to satisfactory outcomes and personal professional success. Communication Skills for Foreign and Mobile Medical Professionals is an evidence-based communication resource book designed for all medical professionals who work in foreign countries, cultures, and languages. It offers a wealth of insights into doctor-patient communication, structured around the different phases of the consultation.
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  • Respiratory system -- Ophthalmology -- Ear conditions -- Central nervous system -- Women's health -- Gastroenterology -- Dermatology -- Musculoskeletal conditions -- Paediatrics -- Specific product requests.
  • The Jacksonville, Florida, experience / J. Benjamin Warner -- Indicators as a structural framework for social change / Charlotte Kahn -- Indicators in action : the use of sustainability indicators in the city of Santa Monica / Genevieve Bertone ... [et al.] -- A measure and method to assess subjective community quality of life / M. Joseph Sirgy and Don Rahtz -- Perception and evaluation of the quality of life in Florence, Italy / Filomena Maggino -- City of Winnipeg quality-of-life indicators / Peter Hardi and László Pintér -- Sustainable Seattle : the case of the prototype sustainability indicators project / Meg Holden -- Using community indicators to improve the quality of life for children : the Sacramento County children's report card / Nancy Findeisen -- Living in a post-apartheid city : a baseline survey of quality of life in Buffalo City / Robin Richards and Ellen Kamman -- Making community indicators accessible through the Census Information Center : Howard University, portals to the community, and the New American University / Rodney D. Green ... [et al.] -- Quality indicators for progress : a guide to community quality-of-life assessments / Marian Chambers and David Swain.
  • Diagnosis and treatment of community acquired pneumonia - the German perspective -- Detection of respiratory bacterial pathogens -- Viral pathogens and epidemiology, detection, therapy and resistance -- Resistance in Streptococcus pneumoniae -- Influenza -- Pathogenesis of Chlamydophila pneumoniae infections - epidemiology, immunity, cell biology, virulence factors -- Legionnaires' disease and its agent Legionella pneumophila -- Pathogenesis of Streptococcus pneumoniae infections: adaptive immunity, innate immunity, cell biology, virulence factors -- Pathogenesis of Mycoplasma pneumoniae infections: adaptive immunity, innate immunity, cell biology, and virulence factors -- Community-acquired pneumonia: paving the way towards new vaccination concepts.
  • What Is Community-Based Participatory Research? -- Background Preparation for the CBPR Process -- Beginning Partnerships with Communities -- Finding Common Ground Within the Partnership -- Sustaining the Partnership -- Evaluating the Partnership and Enhancing Future Successes.
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    [v.1.] Introductory booklet -- [v. 2.] Health component -- [v.3.] Education component -- [v.4.] Livelihood component -- [v.5.] Social component -- [v.6.] Empowerment component -- [v.7.] Supplementary booklet.
  • Conceptual perspectives on the co-occurrence of mental and physical disease : diabetes and depression as a model / E.B. Fisher, J.C.N. Chan, S. Kowitt, H. Nan, N. Sartorius, B. Oldenburg -- Public health perspectives on the co-occurrence of non-communicable diseases and common mental disorders / B. Oldenburg, A. O'Neil, F. Cocker -- Counting all the costs : the economic impact of co-morbidity / D. McDaid, A.L. Park -- Difficulties facing the provision of care for multimorbidity in low-income countries / D. Beran -- Depression, diabetes and dementia / J.D. Rosenblat, R.B. Mansur, D.S. Cha, A. Baskaran, R.S. McIntyre -- Cardiovascular disease and severe mental illness / R.I.G. Holt -- Multiple comorbidities in people with eating disorders / P. Monteleone, F. Brambilla -- Anxiety and related disorders and physical illness / C. Kariuki-Nyuthe, D.J. Stein -- Cancer and mental illness / D. Lawrence, K.J. Hancock, S. Kisely -- Infectious diseases and mental health / N. Müller -- Physical diseases and addictive disorders : associations and implications / A.J. Gordon, J.W. Conley, J.M. Gordon -- The role of general practitioners and family physicians in the management of multimorbidity / P. Boeckxstaens, J. De Maeseneer, A. De Sutter -- Training physicians at the undergraduate and postgraduate levels about co-morbidity / A. Cushing, S. Evans -- The dialogue on diabetes and depression African nursing training programme : a collaborative training initiative to improve the recognition and management of diabetes and depression in Sub-Saharan Africa / H.L. Millar, L. Cimino, A.S. van der Merwe -- The challenge of developing person-centred services to manage co-morbid mental and physical illness / L. Gask -- Prevention of comorbid mental and physical disorders / C. Hosman.
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    v. 1. Anatomy, biochemistry, physiology and related subjects.--v.2. Pharmacology, microbiology, general pathology and related subjects.
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    v. 1. Anatomy, biochemistry, physiology and related subjects.--v. 2. Pharmacology, microbiology, general pathology and related subjects.
  • An introduction to psychiatry -- Functional neuroanatomy -- Neuropharmacology -- Neuroimaging -- Basic psychology -- Social and transcultural aspects of psychiatry -- Neuropsychology -- Genetics in relation to psychiatry -- Research methods, statistics and evidence-based practice -- Clinical assessment: interviewing and examination -- Clinical psychopharmacology -- Psychological therapies -- Organic disorders -- Misuse of, and dependence on, alcohol and other drugs -- Schizophrenia and related disorders -- Mood disorder -- Neurotic, stress-related and somatoform disorders -- Eating disorders -- Personality disorders -- Learning disability -- Psychiatric disorders in childhood and adolescence -- Old-age psychiatry -- Suicide and self-harm -- Psychiatry in general medical settings -- The relationship between crime and psychiatry -- Legal and ethical aspects of psychiatry.
  • 1. Introduction / Piper M. Treuting, Suzanne M. Dintzis, Kathleen S. Montine -- 2. Phenotyping / Cory Brayton, Piper M. Treuting -- 3. Necropsy and Histology / Sue Knoblaugh, Julie Randolph-Habecker, Steve Rath -- 4. Mammary Gland / Robert D. Cardiff, Kimberly H. Allison -- 5. Skeletal System / Christopher Jerome, Benjamin Hoch -- 6. Nose, Sinus, Pharynx, and Larynx / Jack R. Harkema, Stephan A. Carey, James G. Wagner, Suzanne M. Dintzis, Denny Liggitt -- 7. Oral Cavity and Teeth / Piper M. Treuting, Thomas H. Morton Jr. -- 8. Salivary Glands / Piper M. Treuting, Suzanne M. Dintzis -- 9. Respiratory / Carlos Jose Suarez, Suzanne M. Dintzis, Charles W. Frevert -- 10. Cardiovascular / Michael A. Laflamme, Manu M. Sebastian, Bernard S. Buetow -- 11. Upper Gastrointestinal Tract / Piper M. Treuting, Mark A. Valasek, Suzanne M. Dintzis -- 12. Lower Gastrointestinal Tract / Piper M. Treuting, Suzanne M. Dintzis -- 13. Liver and Gallbladder / Arlin B. Rogers, Renee Z. Dintzis -- 14. Pancreas / Suzanne M. Dintzis, Denny Liggitt -- 15. Endocrine System / Krista Marie DuBray La Perle, C. Diana Jordan -- 16. Urinary System / Piper M. Treuting, Jolanta Kowalewska -- 17. Female Reproductive System / Mara H. Rendi, Atis Muehlenbachs, Rochelle L. Garcia, Kelli L. Boyd -- 18. Male Reproductive System / Sue Knoblaugh, Lawrence True -- 19. Hematopoietic and Lymphoid Tissues / Michael Linden, Jerrold M. Ward, Sindhu Cherian -- 20. Nervous System / Catherine E. Hagan, Brad Bolon, C. Dirk Keene -- 21. Special Senses: Eye / Piper M. Treuting, Rachel Wong, Daniel C. Tu, Isabella Phan -- 22. Special Senses: Ear / Piper M. Treuting, Suzanne M. Dintzis -- 23. Skin and Adnexa / John P. Sundberg, Lillian B. Nanney, Philip Fleckman, Lloyd E. King.
  • This volume addresses not only a series of key topics in the discipline of veterinary pharmacology and therapeutics that will be of interest to those researching and treating animal disease, but also emphasising the comparative aspects of the subject and the interface with human health and disease.
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    v. 1. Sources of free energy -- v. 2. Free energy and biological function -- v. 3-5. Constituents of life -- v. 6. Cells and organisms -- v. 7. Supplementary volume. [and Topical subject index, volumes I-VII]
  • Recent trends in health care across the United States and internationally have emphasized a novel approach that consists in comparing the effectiveness and efficacy of treatment interventions with a patient-centered emphasis (i.e., evidence-based health care), while ensuring cost constraints, maximizing benefits, and minimizing risks. In this book, experts in comparative effectiveness and efficacy research and analysis for practice (CEERAP) in health care in general address a range of topical issues. The emphasis is on implications for endodontics and nursing, both of which are considered in a series of detailed chapters. Commonalities and differences among CEERAP, utility-based and logic-based analysis and decision-making, and evidence-based and patient-centered practice are defined and discussed. The book concludes by examining applications for CEERAP in developing patient-centered optimal treatment interventions for the next decade.
  • Despite tremendous recent advances in the treatment of most malignancies, there remain several critical questions for each cancer. This particularly true for the surgical management of solid-organ malignancies. Comparative effectiveness is a relatively new term which encompasses the age-old concepts of how best to treat cancer patients. Comparative effectiveness is defined as the direct comparison of healthcare interventions to determine which work best for which patients when considering the benefits and risks. The Institute of Medicine has defined comparative effectiveness research (CER) as the generation and synthesis of evidence that compares the benefits and harms of alternative methods to prevent, diagnose, treat, and monitor a clinical condition or to improve the delivery of care. CER is certainly best done with well-conducted randomized controlled trials. Unfortunately, clinical trials are not always feasible owing to the impracticality of conducting the trial, the considerable cost, and the time required to complete the trial. These challenges are even more pronounced with respect to surgical treatment. Thus alternative approaches may need to be considered in order to address pressing questions in the care of the oncology patient. These approaches may include well-conducted retrospective cohort studies from cancer registries and other data sources, decision and cost-effectiveness analyses, and other novel methodologies. This book lays out the current critical questions for each major malignancy and proposes approaches to gain answers to these pressing questions.
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    v. 1. Glandular hormones -- v. 2. pt. 1. Invertebrate hormones -- pt. 2. Tissue hormones.
  • Comparative genomics v. 1-2, 2007
    Springer Protocols
    v. 2, 2007 Springer Protocols
    v. 1. Genome visualization and annotation ; Sequence alignments ; Identification of conserved sequences and biases in codon usage ; Identification and structural characterization of noncoding RNAs -- v. 2. Comparative analysis of domain and protein families ; Orthologs, synteny, and genome evolution ; Experimental analysis of whole genomes : analysis of copy number and sequence polymorphisms.
  • This book provides an evolutionary conceptual framework for comparative genomics, with the ultimate objective of understanding the loss and gain of genes during evolution, the interactions among gene products, and the relationship between genotype, phenotype and the environment. The many examples in the book have been carefully chosen from primary research literature based on two criteria: their biological insight and their pedagogical merit. The phylogeny-based comparative methods, involving both continuous and discrete variables, often represent a stumbling block for many students entering the field of comparative genomics. They are numerically illustrated and explained in great detail. The book is intended for researchers new to the field, i.e., advanced undergraduate students, postgraduates and postdoctoral fellows, although professional researchers who are not in the area of comparative genomics will also find the book informative.
  • Introduction : the broad horizons of comparative genomics / James R. Brown -- Advances in next-generation DNA sequencing technologies / Michael L. Metzker -- Large scale phylogenetic reconstruction / Bernard M.E. Moret -- Comparative genomics of viruses using bioinformatics tools / Chris Upton and Elliot J. Lefkowitz -- Archaebacteria and the prokaryote-to-eukaryote transition (and the role of mitochondria therein) / William Martin, Tal Dagan, and Katrin Henze -- Comparative genomics of invertebrates / Takeshi Kawashima ... [et al.] -- Comparative vertebrate genomics / James W. Thomas -- Gaining insight into human population-specific selection pressure / Michael R. Barnes -- Comparative genomics in drug discovery / James R. Brown -- Comparative genomics and the development of novel antimicrobials / Diarmaid Hughes -- Comparative genomics and the development of antimalarial and antiparasitic therapeutics / Emilio F. Merino, Steven A. Sullivan, and Jane M. Carlton -- Comparative genomics in AIDS research / Philippe Lemey, Koen Deforche, and Anne-Mieke Vandamme -- Detailed comparisons of cancer genomes / Timon P.H. Buys ... [et al.] -- Comparative cancer epigenomics / Alice N.C. Kuo ... [et al.] -- G protein-coupled receptors and comparative genomics / Steven M. Foord -- Comparative toxicogenomics in mechanistic and predictive toxicology / Joshua C. Kwekel, Lyle D. Burgoon, and Tim R. Zacharewski -- Comparative genomics and crop improvement / Michael Francki and Rudi Appels -- Domestic animals : a treasure trove for comparative genomics / Leif Andersson.
  • 1. Variable lymphocyte receptor-based adaptive immunity in the Agnathan Sea Lamprey / Marion J. Parsons, Justin T.H. Chan, Heng Sun, and Götz R.A. Ehrhardt -- 2. Immunoglobulin genes in tetrapods / Yi Sun and Yaofeng Zhao -- 3. The immunoglobulin genes of bats / J.E. Butler, Nancy Wertz, and Michelle L. Baker -- 4. Marsupial and monotreme immunoglobulin genetics / Robert D. Miller and Victoria L. Hansen -- 5. Organization of the immunoglobulin heavy- and light-chain loci in the rat / Peter M. Dammers, Jacobus Hendricks, Peter Terpstra, Nicolaas A. Bos, and Frans G.M. Kroese -- 6. Generation of the antibody repertoire in rabbits : role of gut-associated lymphoid tissues / Kari M. Severson and Katherine L. Knight -- 7. The immunoglobulin genes of domestic swine / J.E. Butler and Nancy Wertz -- 8. Bovine immunoglobulin genetics : a phylogenetic perspective / Yfke Pasman and Azad K. Kaushik -- 9. Informatics tools for immunoglobulin gene sequence analysis / Helena Hazanov, Miri Michaeli, Gitit Lavy-Shahaf, and Ramit Mehr.
  • This new volume provides a concise overview of the most basic and exciting chapters of comparative medicine with regards to physiology and function in healthy individuals. The book includes core concepts in anatomy and physiology in human and animal models, which are key to understanding comparative medicine and to making contributions to research in this area. While writing this book, the authors were in constant interdisciplinary dialogue. They aim to contribute to improvements in quality of life for human and animal patients.
  • An introduction to fasting, starvation, and food limitation / Marshall D. McCue -- A history of modern research into fasting, starvation, and inanition / Jean-Hervé Lignot and Yvon LeMaho -- Starvation in rotifers : physiology in an ecological context / Kevin L. Kirk -- Drosophila as a model for starvation : evolution, physiology, and genetics / Alen G. Gibbs and Lauren A. Reynolds -- Metabolic transitions during feast and famine in spiders / Johannes Overgaard and Tobias Wang -- Adaptation of the physiological, endocrine, and digestive system functions to prolonged food deprivation in fish / Nadav Bar and Helene Volkoff -- Starvation in subterranean species versus surface-dwelling species : crustaceans, fish, and salamanders / Frédéric Hervant -- Physiological responses to starvation in snakes : low energy specialists / Marshall D. McCue, Harvey B. Lillywhite, and Steven J. Beaupre -- Cardiovascular circuits and digestive function of intermittent-feeding sauropsids / Rike Campen and Matthias Starck -- Thermoregulatory adaptations to starvation in birds / Esa Hohtola -- Fasting in birds : general patterns and the special case of endurance flight / Susanne Jenni-Eiermann and Lukas Jenni -- Tissue-specific mass changes during fasting : the protein turnover hypothesis / Ulf Bauchinger and Scott R. McWilliams -- Seasonal changes in body mass and energy balance in wild small mammals / Xueying Zhang, Xinyu Liu, and Dehua Wang -- Changes in form and function of the gastrointestinal tract during starvation : from pythons to rats / Jehan-Hervé Lignot -- Changes in fatty acid composition during starvation in vertebrates : mechanisms and questions / Edwin R. Price and Teresa G. Valencak -- Physiological responses to fasting in bats / Miriam Ben-Hamo, Agustí Muñoz-Garcia, and Berry Pinshow -- Muscle protein and strength retention by bears during winter fasting and starvation / Hank Harlow -- Seasonal starvation in northern white-tailed deer / Duane E. Ullrey -- Fasting physiology of the pinnipeds : the challenges of fasting while maintaining high energy expenditure and nutrient delivery for lactation / Cory D. Champagne ... [et al.] -- The use and application of stable isotope analysis to the study of starvation, fasting, and nutritional stress in animals / Kent A. Hatch -- Fearing the danger point : the study and treatment of human starvation in the United Kingdom and India, c. 1880-1974 / Kevin Grant -- Quantitative physiology of human starvation : adaptations of energy expenditure, macronutrient metabolism, and body composition / Kevin D. Hall -- Alternate day fasting : effects on body weight and chronic disease risk in humans and animals / Krista A. Varady -- Horizons in starvation research/ Marshall D. McCue.
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    Leading scientists and science writers reflect on the life-changing, perspective-changing, new science of human goodness.
  • Competition and variation in natural languages : the case for case / Mengistu Amberber and Helen de Hoop -- Some participants are more equal than others : case and the composition of arguments in Kuuk Thaayorre / Alice Gaby -- Head marking and dependent marking of grammatical relations in Yurakaré / Rik van Gijn -- Case pattern splits, verb types and construction competition / Andrej L. Malchukov -- Limits to case--a critical survey of the notion / Andrew Spencer and Ryo Otoguro -- Case as feature checking and the status of predicate initial languages / Lisa deMena Travis -- The case of Basque : an accusative analysis for an ergative system / Mario van de Visser -- Noun phrase resolution : the correlation between case and ambiguity / Peter de Swart -- Changes in case marking in NP : from Old English to Middle English / Cynthia L. Allen -- The on-line resolution of subject-object ambiguities with and without case-marking in Dutch : evidence from event-related brain potentials / Monique Lamers -- Differential subject marking in Amharic / Mengistu Amberber -- Differential case-marking in Hindi / Helen de Hoop and Bhuvana Narasimhan.
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  • Complementary & Alternative Medicine for Prostate and Urologic Health is designed to capture and clinically review the comprehensive database of clinical research articles that support and do not support the utilization of a variety of dietary supplements and other complementary medicines that physicians are exposed to in their daily practice. This is a critical distinction between this book and any other Complementary & Alternative Medicine (CAM) books published to date. Each section of the book provides an easy to reference guide into the topic of interest for the individual that works in urology. The various sub-specialty groups in urology are adequately represented, which allows for a physician to rapidly and thoroughly investigate their topic of interest regardless of whether it is fertility, bladder cancer, or prostate disease. Rather than having to sort through the now thousands of articles published yearly on CAM in medicine, this volume focuses first on the specialty and secondarily how it compares to the overall CAM literature. Each chapter includes a summary page that will allow the physician a rapid review of the subject with a patient, colleague or student.
  • A context for thinking about complementary and alternative medicine and ethics / Lois Snyder -- Complementary and alternative medicine: history, definitions, and what is it today? / Richard J. Carroll -- Complementary and alternative medicine: the physician's ethical obligations / Wayne Vaught -- Advising patients about complementary and alternative medicine / Arti Prasad and Mariebeth B. Velásquez -- Patient and medical education on complementary and alternative medicine: sorting it out / Catherine Leffler -- Legal and risk management in complementary and alternative medicine / Michael H. Cohen -- Whose evidence, which methods? Ethical challenges in complementary and alternative medicine research / Jon Tilburt.
  • Introduction -- Prevalence, cost, and patterns of use -- Contemporary approaches to evidence of treatment effectiveness : a context for CAM research -- Need for innovative designs in CAM (and conventional medicine) -- State of the emerging evidence -- An ethical framework for CAM research, practice, and policy -- Integration of CAM and conventional medicine -- Educational programs in CAM -- Dietary supplements -- Conclusion.
  • Botanical and marine oils for treatment of arthritis -- Prolotherapy for chronic musculoskeletal pain -- Soy and cognition in the aging population -- Valerian and other CAM botanicals in treatment of sleep disturbances -- Botanicals and nutrition in the treatment of epilepsy -- Ginkgo biloba extract in prevention of age-associated diseases in elderly population -- Policosanol to manage dyslipidemia in older adults -- Health promoting benefits of chamomile in the elderly population -- Bamboo extract in the prevention of diabetes and breast cancer -- Cranberry and other dietary supplements for the treatment of urinary tract infections in aging women -- Black cohosh: chemopreventive and anticancer potential -- Integrating comprehensive and alternative medicine into stroke -- Socioeconomic aspects of the use of complementary and alternative medicine -- Noni (Morinda citrifolia) fruit as a functional food and dietary supplement for an aging population -- Botanical treatment for polycystic ovary syndrome -- Eggs and health: nutrient sources and supplement carriers -- Berries and cancer -- Flavonoids and cardiovascular health -- Ibogaine and the treatment of opiate addiction -- The potential of caffine for the inhibition of cognitive decline in the aged -- Five or more servings of fruit and vegetables each day for better health! -- Medicinal uses of vinegar -- Health-promoting effects of grape bioactive phytochemicals -- Isoflavones made simple - agonist activity for the beta-type estrogen receptor may mediate their health benefits -- Signal therapy: propolis and pepper extracts as cancer therapeutics -- Health benefits of traditional culinary and medicinal Mediterranean plants -- Quercetin: a potential complementary and alternative cancer therapy.
  • Aesthetics and aging : a new paradigm -- Preoperative evaluation -- Operative technique -- The postoperative period and management of complications -- Case studies.
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    Energy techniques as a way of returning healing to health care / Carol M. Davis -- Psychoneuroimmunology : the bridge to the coexistence of two paradigms / Carol M. Davis -- Quantum physics and systems theory : the science behind complementary and alternative therapies / Carol M. Davis -- Advances in the science of energy medicine : vibration, photons, and the zero point field / Carol M. Davis -- Therapeutic massage and rehabilitation / Janet Kahn -- Craniosacral therapy / Deborah A. Giaquinto-Wahl -- Myofascial release : the missing link in traditional treatment / John F. Barnes -- Complete decongestive therapy / Barbara Funk -- The Ida Rolf method of structural integration / Judith E. Deutsch -- T'ai chi : choreography of body and mind / Jennifer M. Bottomley -- Biofeedback : connecting the body and mind / Jennifer M. Bottomley -- Yoga therapeutics : an ancient practice in a 21st century setting / Matthew J. Taylor -- The Alexander technique / Diane Zuck -- Feldenkrais method in rehabilitation : using functional integration and awareness through movement to explore new possibilities / James Stephens -- Pilates rehabilitation / Brent Anderson -- Reiki : an alternative and complementary healing therapy / Sangeeta Singg -- Qi gong for health and healing / Jennifer M. Bottomley -- Magnets : what is the evidence of efficacy? / Neil I. Spielholz -- Acupuncture and acupuncture-like therapeutics in physical therapy / Patrick J. LaRiccia, Mary Lou Galantino, and Kerri Sowers -- Therapeutic touch / Ellen Zambo Anderson -- Distance healing / Susan Morrill Ramsey -- Biomedical applications of low-energy lasers / G. Kesava Reddy.
  • Unique ready reference for all complementary medicine, massage,therapy and manual therapy practitioners and students alerting them to 'red flag' symptoms which should be referred for Western medical investigation or emergency medical treatment. When can a patient be safely reassured and when do they need further investigation or treatment? 'Red flags' are clinical signs that suggest a patient needs prompt investigation and treatment for a potentially dangerous situation. Therapists increasingly find themselves working alongside conventionally trained doctors and nurses and it is vital for them to understand conventional medical diagnoses, symptoms and treatments and, crucially, to recognise warning signs of serious disease. This is essential in order to be a safe practitioner. Clare Stephenson's The Complementary Therapist's Guide to Red Flags and Referrals meets this need by providing an easily accessible reference to 'red flag'symptoms, designed especially for therapists. It offers guidance on how best to respond to those symptoms and signs of disease which can be readily discerned through routine history taking and basic examination of the body. The guidance is in language which is accessible to therapists, and clear advice is offered on when to refer patients to conventional medicine practitioners and how to communicate with doctors when making a referral. Clinical syndromes which merit rapid response are summarised for ease of reference.
  • It is imperative that doctors know how to speak the language of business when communicating with insurance companies, hospital administrators, bankers, accountants and other advisors. Like any business, doctors will need to have marketing and branding strategies that will create advantages and differentiation as the practice of medicine becomes increasingly competitive. This book offers suggestions for developing a practice that is both unique and attractive to new and existing patients, and also to other providers. Additionally it helps to identify your practice's strengths and strategize how to best showcase your areas of expertise by providing examples and analyzing the skills of other practicing physcians. The Complete Business Guide for a Successful Medical Practice provides a roadmap for physicians to be not only good clinical doctors but also good businessmen and businesswomen. It will help doctors make a difference in the lives of their patients as well as sound financial decisions for their practice.
  • The Practice of Grant Writing -- The ABCs of Grants -- A Foundation Primer -- A Corporation Primer -- A Government Primer -- An Individual Donor Primer -- You Can Find It Online -- You Can Find It Offline -- Narrowing Your Prospects -- Sow Before You Reap -- Testing the Waters -- Planning for Success, Now and Tomorrow -- The Parts of a Grant Proposal -- Selling Your Project -- Dollars and Cents -- The Cover Letter and Executive Summary -- Repute and Tribute -- Putting It All Together -- Other Types of Applications -- Waiting for and Receiving the Verdict -- Reporting on Success -- Advice for Individual Grant Seekers -- Working as a Freelance Grant Writer -- The Business Side of Freelancing.
  • This book describes key knowledge concepts, skills and up-to-date algorithms pertaining to common emergencies that can take place in a pediatric office, including: seizures, anaphylaxis and shock, and diabetic ketoacidosis. The authors supported by peer review from top specialists in Pediatric Emergency Medicine at the Baylor College of Medicine offer the first comprehensive educational resource on pediatric office emergency preparedness devoted exclusively to the practicing primary care health care provider and his/her team. During emergencies, providers and their staff are called on to.
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  • This book provides up-to-date guidance on the diagnosis and treatment of the most important complex fractures of the limbs, including fractures of the proximal and distal humerus, fractures and dislocations of the elbow, fractures of the distal radius, pelvis, acetabulum, distal femur, proximal tibia, tibial pilon, calcaneus and osteoporotic knee fractures. The most complex articular fractures are analyzed, soft tissue coverage is reviewed, and the management of open fractures and nonunions is described and illustrated. Other chapters consider damage control management and immediate bone fixation in the polytrauma patient, skeletal reconstruction and rehabilitation of complex fractures of the limbs. The book offers guidance to orthopaedic surgeons on which treatment options afford the best preservation of fully functional joints around the fractured bone. With this goal in mind, the authors have developed strategies that can restore full articular function of the limbs in both the short and the long term. Complex Fractures of the Limbs will be an invaluable aid to orthopaedic surgeons in treating patients with this very common and important clinical problem.
  • v. 2 Future Med
    Volume 1. Breast cancer -- High-risk breast lesions / Vance Sohn -- Surgical management of ductal carcinoma in situ / Rosalinda Alvarado -- Regional lymph node metastases in breast cancer / Sarah DeSnyder -- Neoadjuvant/adjuvant therapy for breast cancer / Sarah DeSnyder -- Nonductal malignancies / Sarah DeSnyder -- Management of high-risk breast cancer syndromes / Rosalinda Alvarado -- Reconstruction following breast surgery / Steve Lee & Daniel E. Abbott -- Endocrine malignancies -- Well-differentiated thyroid cancer / Steve Lee & Daniel E. Abbott -- Multiple endocrine neoplasia / Paxton Dickson -- Adrenal pathology and approaches to resection / Daniel E. Abbott -- Melanoma -- Margins in melanoma / Genevieve Boland -- Sentinel lymph node biopsy in melanoma / Genevieve Boland -- In-transit disease and regional therapy / Vance Sohn -- Soft-tissue sarcoma -- Retroperitoneal sarcoma / Alex Haynes -- Adjuvant/neoadjuvant therapy for sarcoma / Christina L. Roland -- Esophageal cancer -- EMR, RFA and argon plasma coagulation for treatment of Barrett's esophagus and early adenocarcinoma / Amanda Cooper -- Distal esophageal tumors / Maria C. Russell -- Squamous cell versus adenocarcinoma of the esophagus / Christina L. Roland -- Index. Volume 2. Gastric cancer -- Gastric adenocarcinoma / Maria Citarella Russell -- Small bowel cancer -- Small bowel neoplasms / Paxton Dickson -- Colorectal cancer -- Management of rectal cancer / Genevieve Boland -- Hereditary colorectal cancer syndromes / Christina Bailey -- Reconstruction after low rectal resections and pelvic exenteration / Amanda Cooper -- Hepatobiliary cancer -- Cholangiocarcinoma / Daniel E. Abbott -- Hepatic metastases / Genevieve Boland -- Resection and ablation techniques for hepatic lesions / Steve Lee & Daniel E. Abbott -- Resection versus transplantation for hepatocellular carcinoma / Christina L. Roland -- Pancreatic cancer -- Pancreatic cystic neoplasms / Robert E. Roses -- Pancreatic adenocarcinoma / Daniel E. Abbott -- Neuroendocrine tumors of the pancreas / Alex Haynes -- Conditions affecting the pancreaticobiliary system / Vance Sohn -- Peritoneal malignancy -- Peritoneal mesothelioma / Vance Sohn -- Index.
  • Biomedical robotics and biomechatronics -- Complex virtual technology in medicine -- Information and communication technology in medicine -- Complex technology in rehabilitation -- Cognitive neuroscience and technology -- Complex bioinformatics.
  • Comprised exclusively of clinical cases covering complex primary and revision total knee arthroplasty, this concise, practical casebook will provide orthopedic surgeons with the best real-world strategies to properly manage the more complicated forms of knee replacement they may encounter. Each chapter is a case that opens with a unique clinical presentation, followed by a description of the diagnosis, assessment and management techniques used to treat it, as well as the case outcome and clinical pearls and pitfalls. Cases included illustrate different management strategies for primary knee arthroplasty, including the varus and valgus knee, flexion contracture and extra-articular deformity, as well as periprosthetic infection and revision total knee arthroplasty, including deficient extensor mechanism, periprosthetic femur fracture and ligamentous instability. Pragmatic and reader-friendly, Complex Primary and Revision Total Knee Arthroplasty: A Clinical Casebook will be an excellent resource for orthopedic surgeons confronted with a challenging knee joint replacement.
  • An overview of the translational dilemma and the need for translational systems biology of inflammation / Yoram Vodovotz and Gary An -- Part I: Complex systems methods and applications. Translational equation-based modeling / Gilles Clermont ; Agent-based modeling in translational systems biology / Scott Christley and Gary An ; Analysis of heart rate variability / Patrick R. Norris ; Analysis of ventilatory pattern variability / Thomas E. Dick [and seven others] -- Part II. Translational modeling of sepsis and trauma. Disorder of systemic inflammation in sepsis and trauma: a systems perspective / Kent R. Zettel II and Timothy R. Billiar ; Multi-scale equation-based models: insights for inflammation and physiological variability / Jeremy D. Scheff ; Integrating data driven and mechanistic models of the inflammatory response in sepsis and trauma / Nabil Azhar [and five others] ; In silico trials and personalized therapy for sepsis and trauma / Yoram Vodovotz, John Bartels, and Gary An -- Part III: Translational modeling of wound healing. Disorder of localized inflammation in wound healing: a systems perspective / Sashwati Roy, Amitava Das, and Chandan K. Sen ; Equation-based models of wound healing and collective cell migration / Julia Arciero and David Swigon ; Agent-based models of wound healing / Jordan R. Stern [and three others] -- Part IV: Translational modeling of host-pathogen interactions. Modeling host-pathogen interactions in necrotizing enterocolitis / Julia Arciero, Jared Barber, and Moses Kim ; Modeling host-vector-pathogen immuno-inflammatory interactions in malaria / Yoram Vodovotz [and nine others] -- Part V: Future perspectives : translation to implementation. The rationale and implementation of translational systems biology as a new paradigm for the study of inflammation / Gary An and Yoram Vodovotz -- Index.
  • Complexities in Colorectal Surgery: Decision-Making and Management provides a unique, modern, practical guide that covers the strategic evaluation, specific approaches, and detailed management techniques utilized by expert Colorectal Surgeons caring for patients with complex problems whether they result from underlying colorectal disease or from complications arising from previous surgical therapy. The text is formatted as both a "how-to" manual as well as an algorithm-based guide allowing the reader to understand the thought process behind the proposed treatment strategies. By making use of evidence-based recommendations, each chapter will include not only diagnostic and therapeutic guidelines, but also a narrative by the author on his/her operative technical details and perioperative "tips and tricks" that they utilize in the management of these complex surgical challenges. This test includes chapters on the assessment of risk and nutritional intervention methods utilized to minimize perioperative complications. In addition, sections on medical and surgical therapies for abdominal, pelvic and anorectal disease are incorporated. Moreover, the technical challenges of managing complications resulting from the original or subsequent operations is addressed. The underlying focus throughout the text is to provide pragmatic and understandable solutions that can be readily implemented by surgeons of varying experience to successfully treat complex colorectal problems. The text also goes beyond the technical aspects of Colorectal Surgery and includes special sections highlighting the essence of a surgeon. These include chapters describing the importance of the first encounter, building patient rapport, and demonstrating confidence and competence while showing humility and avoiding arrogance. Additionally, aspects involving the medical-legal, ethical, and economic challenges confronting surgeons are covered.
  • Ability to learn from errors is an essential aspect of the quest to improve treatment quality and patient safety. This book consists of 33 cases in anesthesiology that are based on real life situations and illuminate avoidable complications and mishaps. The cases are presented in a novel manner in that they are embedded within narratives. The reader comes to each case cold, without any clue as to the content, and each case comprises a narrative and a factual component that are interwoven. The narrative parts provide the reader with information and tips regarding the clinical problems and tasks that the protagonist must face and try to solve. The idea is to engage the reader emotionally while reading and to entertain him or her while learning. All cases conclude with short debriefing sections which include possible strategies to prevent similar errors or mishaps.
  • How can one best master a rupture of the posterior capsule during cataract surgery? How should one operate on a dropped nucleus? What is the ideal management for a subluxated intraocular lens? If you are seeking answers to these and similar questions, then this is the book for you. Every surgeon is afraid of complications, but while complications cannot be entirely avoided, it is possible to learn to master them. This practical handbook clearly explains how to manage the various complications that may arise during cataract surgery. It provides the surgeon with clear instructions on how best to proceed in the manner of a cookbook, by first describing the ingredients (equipment) and preparation (planning) and then providing step by step descriptions of technique with the aid of numerous helpful color illustrations and several accompanying surgical videos. Surgical pearls and pitfalls are highlighted. Using this book, the reader will become a better and more complete cataract surgeon, well equipped to cope with the full range of potential complications.
  • Summary contents: Pharmacology -- Vasoactive drugs -- Cardiac drugs -- Adjunct therapy -- Anesthetic drugs -- Anesthetic adjuncts -- Miscellaneous drugs and related topics -- General anesthesia -- Preanesthetic assessment -- Anesthetic management issues -- Ancillary topics -- Regional anesthesia and pain management -- Actue and chronic pain management -- Cardiothoracic and vascular surgery -- Thoracic surgery -- Vascular surgery -- Cardiovascular device therapy -- Physiologic imbalance and coexisting disease -- Coexisting disease and altered states -- Equipment and monitoring -- Anesthetic equipment -- Ancillary systems -- Monitoring devices -- Pediatrics and neonatology -- Perioperative management -- Coexisting disease and altered states -- Surgery-related and other issues -- Neurosurgery, ophthalmology, ENT -- Neurosurgery -- Ophthalmology -- Ear, nose, and throat -- Other surgical subspecialties -- Obstetrics and gynecology -- General surgery -- Urologic surgery -- Orthopedic surgery -- Special topics -- Postanesthesia care unit -- Diganostic or therapeutic intervention -- Medicolegal aspects. 1. Vasodilator Drugs -- 2. Vasopressors: Vasoconstrictor Drugs -- 3. Inotropic Drugs -- 4. Chronotropic Drugs -- 5. Drugs Affecting the Renin-Angiotensin System -- 6. Phosphodiesterase Inhibitors -- 7. Digitalis -- 8. Anticholinergics -- 9. Adenosine -- 10. Class I Antiarrhythmic Drugs: Ventricular Proarrhythmia -- 11. Class II Antiarrhythmic Drugs: β-Blockers-Heart Block or Bradycardia -- 12. Class III Antiarrhythmic Drugs: Potassium Channel Blockers -- 13. Class IV Antiarrhythmic Drugs: Calcium Channel Blockers -- 14. Disorders of Potassium Balance -- 15. Magnesium -- 16. Perioperative Fluid Management -- 17. Volatile Anesthetics: Organ Toxicity -- 18. Nitrous Oxide: Neurotoxicity -- 19. Intrathecal Opiates -- 20. Barbiturates: Porphyrias -- 21. Ketamine -- 22. Nonbarbiturate Anesthetics -- 23. Succinylcholine -- 24. Nondepolarizing Neuromuscular Relaxants -- 25. Antihistamines: H1 - and H2 -Blockers -- 26. α2 -Adrenoreceptor Agonists -- 27. Anaphylaxis and Anaphylactoid Reactions -- 28. Antibiotics -- 29. Antidepressants -- 30. Chemotherapeutic Agents -- 31. Chemical Dependency: Opioids -- 32. Chemical Dependency: Nonopioids -- 33. Reversal Agents: Naloxone and Flumazenil -- 34. Steroids -- 35. Antiemetic Drugs -- 36. Preanesthetic Evaluation: False-Positive Tests -- 37. Preanesthetic Evaluation: Inadequate or Missing Test Result -- 38. Cardiac Risk Assessment -- 39. Herbals and Alternative Medicine -- 40. Difficult Airway: Cannot Ventilate, Cannot Intubate -- 41. Difficult Airway: Opiate-Induced Muscle Rigidity -- 42. Unstable Cervical Spine, Atlantoaxial Subluxation -- 43. Dental Injuries -- 44. Laryngeal and Tracheal Injury -- 45. Pulmonary Aspiration -- 46. Bronchospasm -- 47. Perioperative Hypoxia -- 48. Patients with Seizure Disorders -- 49. Blood and Blood Products: Transfusion Reaction -- 50. Blood and Blood Products: Hepatitis and HIV -- 51. Nosocomial Infections: Bacterial Pneumonia -- 52. Postobstruction Pulmonary Edema -- 53. Latex Reactions in Health Care Personnel -- 54. Spinal Anesthesia: Post-Dural Puncture Headache -- 55. Local Anesthetic Neurotoxicity: Cauda Equina Syndrome -- 56. Local Anesthetic Systemic Toxicity -- 57. Spinal Hematoma -- 58. Infectious Complications of Central Neuraxial Block -- 59. Epidural Anesthesia: Unintended Intrathecal Injection -- 60. Epidural Anesthesia: Unintended Subdural Injection -- 61. Interscalene Nerve Block: Potential Severe Complications -- 62. Supraclavicular and Infraclavicular Block: Pneumothorax -- 63. Celiac Plexus Block: Side Effects and Complications -- 64. Psoas Compartment Block: Potential Complications -- 65. Side Effects of Neuraxial Opioids -- 66. Complications in Orthopedic Outpatients Not Receiving Peripheral Nerve Blocks -- 67. Anticoagulants and Peripheral Nerve Block -- 68. Chronic Nonsteroidal Anti-inflammatory Drug Use -- 69. Opioid Tolerance -- 70. Continuous Nerve Blocks: Perineural Local Anesthetic Infusion -- 71. Persistent Paresthesia -- 72. Anticoagulation Initiation and Reversal for Cardiac Surgery -- 73. Hemodilution and Blood Conservation -- 74. Troubleshooting Common Problems during Cardiopulmonary Bypass -- 75. Bleeding after Cardiac Surgery -- 76. Perioperative Myocardial Ischemia and Infarction -- 77. Perioperative Hypertension -- 78. Postoperative Pulmonary Hypertension -- 79. Perioperative Tachyarrhythmias -- 80. Tachyarrhythmias with Ventricular Preexcitation -- 81. Long QT Syndromes and Ventricular Arrhythmias -- 82. Bradyarrhythmias -- 83. Adverse Neurologic Sequelae: Peripheral Nerve Injury -- 84. Adverse Neurologic Sequelae: Central Neurologic Impairment -- 85. Postoperative Acute Renal Failure -- 86. Postoperative Respiratory Failure -- 87. Major Organ System Dysfunction after Cardiopulmonary Bypass -- 88. Fast-Track Cardiac Surgery -- 89. Hypercoagulable States: Thrombosis and Embolism -- 90. One-Lung Ventilation -- 91. Mediastinal Masses -- 92. Complications after Pneumonectomy -- 93. Carotid Endarterectomy -- 94. Thoracic Aortic Aneurysm -- 95. Abdominal Aortic Aneurysm Repair -- 96. Peripheral Vascular Surgery -- 97. Patients with Cardiac Rhythm Management Devices -- 98. Mechanical Assist Devices -- 99. Hyperglycemia and Diabetic Ketoacidosis -- 100. Hypothermia -- 101. Hyperthermia -- 102. Angioedema and Urticaria -- 103. Disorders of Water Homeostasis: Hyponatremia and Hypernatremia -- 104. Metabolic Acidosis and Alkalosis -- 105. Adrenal Insufficiency -- 106. HIV Infection and AIDS -- 107. Hypothyroidism: Myxedema Coma -- 108. Hyperthyroidism: Thyroid Storm -- 109. Sarcoidosis -- 110. Perioperative Management of Dialysis-Dependent Patients -- 111. Perioperative Care for Pa tients with Hepatic Insufficiency (Cirrhosis) -- 112. Porphyrias -- 113. Acute Pancreatitis -- 114. Autonomic Hyperreflexia -- 115. Perioperative Management of Patients with Muscular Dystrophy -- 116. Myasthenic Disorders -- 117. Parkinson's Disease -- 118. Alzheimer's Disease -- 119. Sepsis, Systemic Inflammatory Response Syndrome, and Multiple Organ Dysfunction Syndrome -- 120. Perioperative Care of Immunocompromised Patients -- 121. Thermally Injured Patients -- 122. Complications from Toxic Ingestion -- 123. Pipeline Source Failure -- 124. Flowmeters -- 125. Proportioning Systems -- 126. Oxygen Flush Valve -- 127. Anesthesia Circuit -- 128. Vaporizers -- 129. Carbon Dioxide Absorbers -- 130. Mechanical Ventilators -- 131. Scavenging Systems -- 132. Humidifiers -- 133. Intravenous Drug Delivery Systems -- 134. Patient Warming Systems -- 135. Rapid Fluid and Blood Delivery Systems -- 136. Surgical Diathermy and Electrocautery -- 137. Electrical Safety -- 138. Fires in the Operating Room -- 139. Laser Complications -- 140. Pulse Oximetry -- 141. Inspiratory and Expiratory Gas Monitoring -- 142. Transesophageal Echocardiography -- 143. Arterial Blood Pressure Monitoring -- 144. Central Venous Pressure Monitoring -- 145. Pulmonary Artery Pressure Monitoring -- 146. Intracranial Pressure Monitoring -- 147. Pediatric Laryngospasm -- 148. Difficult Pediatric Airway -- 149. Anesthetic Complications of Fetal Surgery: EXIT Procedures -- 150. Postoperative Apnea in Infants -- 151. Intraoperative Cardiac Arrest -- 152. Sedation of Pediatric Patients -- 153. Muscle Relaxants -- 154. Delayed Emergence in Pediatric Patients -- 155. Postintubation Croup -- 156. Postobstruction Pulmonary Edema in Pediatric Patients -- 157. Hypoxemia -- 158. Perioperative Aspiration Pneumonitis -- 159. Postoperative Nausea and Vomiting -- 160. Upper Respiratory Tract Infection -- 161. Latex Allergy -- 162. Malignant Hyperthermia -- 163. Hypoglycemia and Hyperglycemia -- 164. Pulmonary Hypertension -- 165. Hypothermia in Pediatric Patients -- 166. Cardiomyopathies -- 167. Anterior Mediastinal Mass -- 168. Air Emboli -- 169. Complications of Massive Transfusion -- 170. Perioperative Psychological Trauma -- 171. Emergence Agitation -- 172. Adenotonsillectomy -- 173. Ophthalmic Problems and Complications -- 174. Intracranial Hypertension -- 175. Venous Air Embolism -- 176. Posterior Fossa Surgery -- 177. Pituitary Tumors: Diabetes Insipidus -- 178. Intracranial Aneurysms: Rebleeding -- 179. Intracranial Aneurysms: Vas ospasm and Other Issues -- 180. Arteriovenous Malformation: Normal Perfusion Pressure Breakthrough -- 181. Pediatric Neurosurgery -- 182. Head Injury -- 183. Spinal Cord Injury -- 184. Corneal Injury -- 185. Open Globe Injury -- 186. Retrobulbar Block -- 187. Laryngoscopy and Microlaryngoscopy -- 188. Foreign Body Aspiration -- 189. Hypertensive Disorders of Pregnancy -- 190. Preterm Labor -- 191. Fetal Intrauterine Surgery -- 192. Fetal Distress -- 193. Antepartum Hemorrhage -- 194. Postpartum Hemorrhage -- 195. Pulmonary Aspiration in the Parturient -- 196. Embolic Events of Pregnancy -- 197. Peripartum Neurologic Complications -- 198. Postpartum Headache Other Than Post-Dural Puncture Headache -- 199. Nonobstetric Surgery during Pregnancy -- 200. Cardiopulmonary Bypass in Pregnancy -- 201. Postoperative Hepatic Dysfunction -- 202. Surgery in the Morbidly Obese -- 203. Complications of Carcinoid Tumors -- 204. Complications of Thyroid Surgery -- 205. Complications of Adrenal Surgery -- 206. Complications of Trauma Surgery -- 207. Complications of Laparoscopic Surgery -- 208. Postoperative Urinary Retention -- 209. Intraoperative Penile Erection -- 210. Complications of Transurethral Surgery -- 211. Complications of Radical Urologic Surgery -- 212. Complications of Lithotripsy -- 213. Autonomic Dysreflexia -- 214. Complications of Deliberate Hypotension: Visual Loss -- 215. Fat Embolism Syndrome -- 216. Thromboembolic Complications -- 217. Methylmethacrylate -- 218. Extremity Tourniquets -- 219. Complications of Spinal Surgery -- 220. Postoperative Respiratory Insufficiency -- 221. Postoperative Peripheral Neuropathy -- 222. Delayed Emergence -- 223. Postoperative Delirium -- 224. Intractable Nausea and Vomiting -- 225. Unanticipated Hospital Admission and Readmission -- 226. Uncontrolled Pain -- 227. Hemodynamic Instability -- 228. Anesthesia for Electroconvulsive Therapy -- 229. Cardioversion -- 230. Radiation Oncology -- 231. Embolization Procedures -- 232. Catheter Ablation for Arrhythmias -- 233. Magnetic Resonance Imaging -- 234. Misidentification of a Patient -- 235. Syringe Swaps -- 236. Quality Assurance -- 237. Cost Containment -- 238. Alleged Malpractice -- 239. The Hostile-Combative Patient -- 240. Awareness under Anesthesia -- 241. Adverse Outcomes: Withheld Information or Misinformation -- 242. Patient Confidentiality -- 243. Do-Not-Resuscitate Orders in the Operating Room -- 244. The Jehovah's Witness Patient.
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  • Section I. Acute Surgical Complications -- Preoperative Evaluation / Marcy Neuburg -- Acute Emergencies in the Dermatology Office / Darrell J. Fader -- Nerve Injury / Shawn Allen and Roberta Sengelmann -- Hemorrhagic Complications in Cutaneous Surgery / Hugh M. Gloster -- Wound Infections / Gregory John Fulchiero and Elizabeth M. Billingsley -- Prophylaxis for Wound Infections and Endocarditis / Michelle Pipitone and Hugh M. Gloster -- Dehiscence and Necrosis / Ross M. Campbell and Raymond G. Dufresne -- Section II. Chronic Surgical Complications -- Hypertrophic Scars and Keloids / A. Paul Kelly -- Free Margin Distortion / Sumaira Z. Aasi and David Leffell -- Scar Revision and Camouflage / Tri H. Nguyen -- Miscellaneous Complications / Mary E. Maloney and Nathaniel J. Jellinek -- Section III. Complications of Cosmetic Procedures -- Preoperative Cosmetic Consultation and Psychological Complications of Cosmetic Surgery / Evan C. Jones and Dee Anna Glaser -- Complications of Ablative and Nonablative Lasers and Light Sources / Elizabeth L. Tanzi and Tina S. Alster -- Complications of Dermabrasion and Chemical Peeling Procedures / Chris Harmon and Betty Davis -- Complications of Liposuction / J. Barton Sterling and C. William Hanke -- Complications of Soft Tissue Fillers / Steven C. Bernstein -- Complications of Botulinum Toxin / Deborshi Roy and Neil S. Sadick -- Complications of Sclerotherapy / Girish S. Munavalli and Robert A. Weiss -- Complications of Facelifting Procedures / Greg S. Morganroth, Hayes B. Gladstone and Isaac M. Neuhaus.
  • The book provides cutting-edge knowledge on how to avoid and manage complications resulting from laser surgery, photodynamic therapy, hair transplantation, chemical peeling, dermabrasion, leg vein treatments, temporary fillers, permanent fillers, botulinum toxin, liposuction, blepharoplasty, facelifts and ancillary facial cosmetic surgery procedures, skin cancer surgery/Mohs micrographic surgery, reconstructive surgery, electrosurgery, cryosurgery, nail surgery, and contact dermatitis in dermatologic surgery. The preparation of the patient, psychosocial issues, and anesthesia complications for all procedures are also covered.
  • "This book presents up-to-date recommendations for the prevention, diagnosis, and management of complications in endodontic surgical procedures, based on the best available scientific evidence. Common risks such as wound healing impairment, infection, and bleeding are discussed, and specific complications related to endodontic surgery, such as maxillary sinus involvement and damage to adjacent neurovascular structures, are reviewed. For each step of endodontic surgical procedures, surgical goals and possible outcomes are reviewed. Preoperative, intraoperative, and postoperative risk factors for complications are identified, and treatment options presented. Helpful decision-making algorithms, tables, and flow charts complement the reader-friendly text."--Publisher's website.
  • Part 1: General topics -- Anesthesia complications in head and neck surgery / Errol P. Lobo, Francesca Pellegrini, and Elisabetta Pusceddu -- Nutritional management in head and neck cancer / Marc D. Coltrera -- Wound healing / Bradley A. Schiff -- Postoperative infection / Rebecca E. Fraioli and Jonas T. Johnson -- Medical complications of head and neck surgery / Joshua S. Adler and Andrew D. Auerbach -- Complications of pediatric head and neck surgery / Andrew F. Inglis, Jr., and Mark A. Richardson -- Complications of geriatric head and neck surgery / Eric M. Genden -- Endocrine complications of head and neck surgery / Mimi I. Hu and Steven I. Sherman -- Ophthalmic and orbital complications of head and neck surgery / Chistopher I. Zoumalan ... [et al.] -- Neurosurgical complications / Ivan H. El-Sayed, Hazem Mohammad Ali Saleh, and Michael W. McDermott -- Complications in interventional neuroradiology of the head and neck / Lee H. Monsein and Christopher F. Dowd -- Head and neck surgical fires / Mark E. Bruley -- Quality of care and patient safety / Robert M. Wachter -- Complications of radiation therapy / Laura Ellen Millender -- Chemotherapy in head and neck cancer / Missak Haigentz, Jr. -- Pain management for head and neck surgery / Tracey Straker -- Postoperative dysphagia / Timothy M. McCulloch, Haskins Kashima, and Michelle Ciucci -- Palliative medicine and end-of-life care / Francine Rainone -- Quality of life in head and neck cancer / Shatul L. Parikh and Amy Y. Chen -- Part 2: Salivary glands, oral cavity, and oropharynx -- Complications of surgery of the salivary glands / M. Boyd Gillespie and David W. Eisele -- Complications of surgery of the parapharyngeal space / Eric Jason Moore and Kerry D. Olsen -- Complications of lip surgery / Mark G. Shrime ... [et al.] -- Complications of surgery of the oral cavity / Jay O. Boyle and Vincent Reid -- Dental complications / Brian L. Schmidt -- Complications of cleft lip and palate surgery / Jennifer L. Rhodes and David Alan Staffenberg -- Temporomandibular joint surgery / M. Anthony Pagrel -- Complications of surgery of the oropharynx / Karen T. Pitman -- Complications of tonsillectomy and adenoidectomy / Thomas J. Ow and Sanjay R. Parikh -- Complications of sleep surgery / Eric J. Kezirian -- Part 3: Larynx, trachea, and hypopharynx -- Complications of endoscopy: rigid and flexible / Mark S. Courey -- Complications of percutaneous gastrostomy / Rohan R. Walvekar and Robert L. Ferris -- Complications of intubation and emergency airway management / M. Boyd Gillespie, Brian Craig, and Stephen F. Dierdorf -- Complications of laryngeal surgery / Richard V. Smith -- Complications of tracheostomy and tracheal surgery / Ivan H. El-Sayed, Amol M. Bhatki, and Nissim Khabie -- Complications of hypopharyngectomy and hypopharyngeal reconstruction / Adam S. Jacobson and Eric M. Genden -- Part 4: Neck, thyroid, and parathyroid -- Complications of surgery of the neck / Wayne M. Koch -- Complications of endoscopic neck surgery / Susan K. Anderson and David J. Terris -- Complications of surgery of the carotid artery / Bruce A. Perler -- Complications of thyroid surgery / Christine G. Gourin and David W. Eisele -- Complications of parathyroid surgery / Lisa A. Orloff -- Part 5: Nose, paranasal sinuses, and aesthetic surgery -- Complications of nasal surgery and epistaxis management / Alexis H. Jackman and Marvin P. Fried -- Complications of surgery of the paranasal sinuses / Amol M. Bhatki and Andrew N. Goldberg -- Complications of rhinoplasty / David W. Kim and M. Jafer Ali -- Complications of maxillectomy / Jarrod Little and Jeffrey M. Bumpous -- Complications of transsphenoidal hypophysectomy / Karen A. Kölln and Brent A. Senior -- Complications of maxillofacial trauma surgery / David M. Saito and Andrew H. Murr -- Complications of facial rejuvenation surgery / Corinne Elisabeth Horn and J. Regan Thomas -- Injury of the facial nerve / Holger G. Gassner and Kris S. Moe -- Complications of chemical peels, dermabrasion, and laser resurfacing / F. Brian Gibson and Stephen W. Perkins -- Complications of facial implants / Jonathan M. Sykes -- Part 6: Skull base and ear -- Complications of anterior skull-base surgery / Dennis H. Kraus, Mark H. Bilsky, and Jerry Lin -- Complications of lateral skull-base surgery / Frank R. Lin and John K. Niparko -- Complications of acoustic neuroma surgery / C. Y. Joseph Chang, Brian S. Wang, and Steven W. Cheung -- Complications of surgery of the vestibular system / Timothy E. Hullar -- Complications of tympanomastoidectomy / Ronald A. Hoffman -- Complications of ear surgery / Joseph G. Feghali ... [et al.] -- Complications of cohlear implanation / Lawrence R. Lustig -- Complications of congenital aural atresia and external auditory canal surgery / Paul R. Lambert -- Complications of otoplasty / Matthew B. Zavod, Theodore Chen, and Peter A. Adamson -- Part 7: Reconstructive surgery -- Complications of pedicled myocutaneous flaps / Francisco J. Civantos and James L. Netterville -- Complications of local facial flaps / Matthew Ashbach, Craig S. Murakami, and Mark S. Zimbler -- Complications of free-tissue transfer / Steven J. Wang, Theodoros N. Teknos, and Douglas B. Chepeha -- Complications of skin, cartilage, and bone grafts / Vicente A. Resto and Daniel G. Deschler.
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  • "This reference provides practical information on complications encountered during and after surgical procedures. It covers preoperative, intra-operative, and postoperative events such as organ transplant, amputations, nerve and fracture repair, and skin grafting. The author offers detailed guidance and techniques to recognize and control complications in the operating room, emergency ward, and intensive care unit. It includes surgical sub-specialties such as critical care, endocrine, cardiothoracic, vascular, burns and wound healing, orthopedic, pediatric, and transplants. The new edition has been revised and reorganized to include nine new chapters and an update of the remaining chapters"--Provided by publisher.
  • Pathogenesis and Evolution of Liver Fibrosis: Cirrhosis or Cirrhoses? -- Natural History of Cirrhosis -- Prediction of Complications of Cirrhosis: Molecular Biomarkers -- Predictors of Clinical Complications of Cirrhosis -- Non-Invasive Markers of Fibrosis in the Assessment of Cirrhosis -- Diagnosis of cirrhosis: Imaging -- Measurement of Portal Pressure and Transjugular Liver Biopsy -- Reversal of Cirrhosis -- Esophageal Varices: Primary and Secondary Prophylaxis -- Acute Variceal Bleeding -- Gastric and Ectopic Varices -- Portal Hypertensive Gastropathy and Gastric Antral Vascular Ectasia (GAVE) -- Ascites and Refractory Ascites Arun Sanyal -- Hyponatremia in Cirrhosis -- Hepatorenal syndrome -- Hepatic Encephalopathy -- Cirrhotic Cardiomyopathy: Pathogenic Mechanisms and Management Strategies -- Hepatopulmonary syndrome -- Portopulmonary Hypertension -- Portal Vein Thrombosis -- Coagulation Disorders in Patients with Cirrhosis -- Hepatocellular Carcinoma -- Cholangiocarcinoma -- Bacterial Infections in Patients with Cirrhosis -- Acute-on-Chronic Liver failure (ACLF) -- Liver support systems -- Liver Transplantation -- Assessment and management of the patient with cirrhosis undergoing surgery -- Promoting a Healthy Lifestyle, Managing Hyperlipidemia, Diabetes Mellitus, Hypertension and Immunizations in Patients with Cirrhosis -- Malnutrition in Patients with Cirrhosis -- Bone disease in Patients with Cirrhosis -- The Economic Cost of Cirrhosis -- Delivering Quality Care to Patients with Cirrhosis: A Practical Guide for Clinicians -- Quality of life issues for patients with cirrhosis -- Palliative Care in Cirrhosis -- Ethical Issues in End Stage Liver Disease: A Framework for Assessment and the Challenges.
  • Written and edited by leading international authorities in the field, this book provides an in-depth review of knowledge of complications of CSF shunting, with emphasis on prevention, identification, and management. It covers the full range of shunt-related complications and the various associated adverse consequences that remain common despite significant improvements in imaging techniques and therapeutic methods. The chapters are organized into three parts: introduction, complications of extrathecal CSF shunt devices, and complications of endoscopy. In addition to providing clinicians and investigators with the most pertinent current evidence, the book looks forward to future areas of hydrocephalus research and to innovative therapeutic philosophies. This comprehensive reference book will be an ideal source for neurosurgeons seeking both basic and more sophisticated information and procedures relating to the complications associated with CSF shunting. It will also contribute in overcoming the problem of lack of knowledge of basic fluid dynamics and workings of the shunts ? knowledge that is essential for optimal care of hydrocephalic patients.
  • Complications of Female Incontinence and Pelvic Reconstructive Surgery reviews the prevention, evaluation and management of complications arising from female pelvic surgery. Potential complications of both routine and specialized female pelvic procedures such as transvaginal slings, cystocele and rectocele repairs, urethral diverticulectomy, and transvaginal mesh repairs are reviewed. The chapters are divided by procedure allowing the reader to easily find what they are looking for. Images and figures of methods of evaluation and repair of these complications are included throughout. The volume is organized based on the specific types of surgeries performed and the user is able to look up the type of surgery performed and immediately find all of the potential complications and their treatments. This text will serve as a comprehensive guide and reference allowing the surgeon quick and ready access to information about the complications of female pelvic surgery.
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  • Physiology of laparoscopy and pneumoperitoneum -- Anesthesia and management of anesthetic complications of laparoscopic urological surgery -- Metabolic and renal complications and immunologic implications of laparoscopic urologic surgery -- Positional and neuromuscular complications of laparoscopic and robotic urologic surgery -- Vascular complications in laparoscopic and robotic urologic surgery -- Urinary and urologic complications of laparoscopic and robotic urologic procedures -- Visceral and gastrointestinal complications of laparoscopic and robotic urologic surgery -- Complications of robotic-assisted laparoscopic surgery: iatrogenic and doulogenic -- Complications of laparoscopic and robotic adrenal surgery -- Complications of laparoscopic radical nephrectomy and nephroureterectomy -- Complications of laparoscopic donor nephrectomy -- Complications of laparoscopic partial nephrectomy -- Complications of robotic partial nephrectomy -- Complications of laparoscopic retroperitoneal lymph node dissection -- Complications of laparoscopic and robotic pyeloplasty -- Complications of laparoscopic and robotic ureteral surgery -- Complications of robotic prostatectomy -- Methods and maneuvers for improving functional outcomes during robotic radical prostatectomy -- Complications of laparoscopic and robotic-assisted radical cystectomy -- Complications of laparoscopic and robotic reconstructive procedures for urinary incontinence and pelvic organ prolapse -- Complications of single port laparoscopic and robotic surgery -- Complications of ablative renal procedures -- Complications of laparoscopic and robotic pediatric urologic surgery -- Medicolegal aspects of minimally invasive urologic surgery.
  • 1.2 million myocardial infarctions occurred last year in the U.S., and 480,000 patients died following complications of infarction. Now, you can detect and treat the many complications associated with myocardial infarction in time to save many more patients. This title in the brand-new Clinical Diagnostic Imaging Atlas Series offers you authoritative guidance from a well-known cardiologist and imaging expert about when and how to perform the latest diagnostic imaging tests, interpret the results, and effectively treat the emergency. Detailed discussions of hot topics, full-color illustrations, and a DVD of procedural video clips, animations, and downloadable image libraries help you provide fast, appropriate treatment for each challenging case you face. Offers detailed advice on when and how to screen for the most prevalent but often difficult-to-diagnose complications of myocardial infarction to help you improve care and increase survival rates. Discusses the hottest topics in myocardial infarction, including cardiogenic shock ₅ left ventricle remodeling ₅ thrombi ₅ right ventricle infarction ₅ free wall rupture ₅ false aneurysms ₅ tamponade ₅ ventricular septal rupture ₅ papillary muscle rupture ₅ and more that prepare you to better diagnose and manage whatever you see. Presents 70 fully illustrated case presentations with teaching points that make information easy to understand and digest. Addresses the advantages and limitations of chest radiology, transthoracic and transesophageal echocardiography, cardiac CT, MR, angiography, and nuclear cardiology techniques so you can quickly determine the best imaging approach. Includes supporting evidence and current AHA/ACC guidelines for more accurate interpretations of your imaging findings. Uses a consistent, easy-to-follow chapter format that includes topic overview, an outline of imaging/diagnostic options, and case-based examples to make reference easy. Provides more than 400 full-color illustrations for expert visual guidance. Includes a bonus DVD containing hundreds of video clips of techniques and animations that show you what to look for and how to proceed as well as downloadable image libraries for use in electronic presentations.
  • Introduction / Samuel M. Butman -- Complications of the Medications / Paul E. Nolan and Toby C. Trujillo -- Groin Complications / Raghunandan Kamineni and Samuel M. Butman -- Complications of Plain Old Balloon Angioplasty / David P. Lee -- Coronary Guidewire Complications / Antonio J. Chamoun and Barry F. Uretsky -- Complications Related to Coronary Stenting / Samuel M. Butman -- Complications of Atherectomy Devices / Gurpreet Baweja, Ashish Pershad, Richard R. Heuser and Samuel M. Butman -- The No-Reflow Phenomenon / H. M. Omar Farouque and David P. Lee -- Early versus Late Complications / Albert W. Chan and Christopher J. White -- Complications of Radiation Exposure and Therapy / William L. Ballard -- Complications of Closure Devices / Raghunandan Kamineni and Samuel M. Butman -- Legal Complications of Percutaneous Coronary Procedures / Peter Akmajian -- Cardiac Arrest and Resuscitation During Percutaneous Coronary Interventions / Karl B. Kern and Hoang M. Thai -- Adverse Event Reporting: Physicians, Manufacturers, and the Food and Drug Administration / Eva B. Manus.
  • Regional anesthesia safety / John W.R. McIntyre -- Outcome studies comparing regional and general anesthesia / Gabriella Iohom and George Shorten -- Avoiding complications in regional anesthesia / Richard W. Rosenquist -- Local anesthetic toxicity / David L. Brown -- Mechanisms of neurologic complications with peripheral nerve blocks / Alain Borgeat, Stephan Blumenthal, and Admir Hadžić -- Complications of ophthalmic regional anesthesia / Robert C. (Roy) Hamilton -- Complications of paravertebral, intercostal nerve blocks, and interpleural analgesia / Nirmala R. Abraham Hidalgo and F. Michael Ferrante -- Complications of brachial plexus anesthesia / Brendan T. Finucane and Ban C.H. Tsui -- Complications associated with spinal anesthesia / Pekka Tarkkila -- Complications of epidural blockade / Ciaran Twomey and Ban C.H. Tsui -- Complications of other peripheral nerve blocks / Guido Fanelli, Andrea Casati, and Daniela Ghisi -- Complications of intravenous regional anesthesia / Dominic A. Cave and Barry A. Finegan -- The evidence-based safety of pediatric regional anesthesia and complications / Lynn M. Broadman and Ryan A. Holt -- Complications of obstetric regional anesthesia / Paul J. O'Connor -- Complications of catheter techniques / Per H. Rosenberg -- Regional anesthesia complications related to acute pain management / Narinder Rawal -- Complications of regional anesthesia in chronic pain therapy / Philip W.H. Peng and Vincent W.S. Chan -- Major neurologic injury following central neural blockade / David J. Sage and Steven J. Fowler -- Regional anesthesia and infection / Terese T. Horlocker and Denise J. Wedel -- Regional anesthesia in the presence of neurologic disease / Andrea Kattula, Giuditta Angelini, and George Arndt --Evaluation of neurologic injury following regional anesthesia / Quinn H. Hogan, Lloyd Hendrix, and Safwan Jaradeh -- Cae studies of regional anesthesia / William F. Urmey -- International morbidity studies on regional anesthesia. Complications associated with regional anesthesia: an American Society of Anesthesiologists' closed claims analysis / Lorri A. Lee and Karen B. Domino. Complications of regional anesthesia leading to medical legal action in Canada / Kari G. Smedstad. Neurologic complications of regional anesthesia in the Nordic countries / Nils Dahlgren. Medicolegal claims: summary of an Australian study / Alber H. Santora. Regional anesthesia morbidity study: France / Yves Auroy and Dan Benhamou -- Medicolegal aspects of regional anesthesia / Albert H. Santora.
  • "Complications of Urologic Surgery: Prevention and Management, 4th Edition, by Samir S. Taneja, MD, is a urology resource that presents current management strategies - with an emphasis on prevention - for the most effective patient care. Recognized leaders in the field address both office-based complications as well as common and uncommon surgical complications arising from open and minimally invasive urologic surgery, to equip you to handle a wide range of situations. Best of all, this resource includes a companion website featuring the complete text of the book, along with case studies, multiple choice questions, and more, for convenient reference and review."--BOOK JACKET.
  • The volume presents current material on the key neurobiological and genetic elements in an individual's susceptibility to drug dependence as well as the processes by which some individuals proceed from casual drug use to drug dependence. Chapters describe and explain the neurobiological mechanisms of drug use and drug addiction. The development and use of animal models to study neurochemical, molecular and cellular brain mechanisms are described and illustrated. Other chapters discuss the effects of drug use on memory, decision-making, and the developing brain (especially in adolescents).
  • Volume 3, Intervention for Addictions, provides chapters on psychosocial treatments, pharmacological treatments, provision of health care to addicted individuals, prevention, and public policy issues. Basically, this volume contains the practical application of the information in Volumes 1 and 2. Overall, this volume provides a detailed picture of the myriad of science-based interventions available for the treatment of addiction. With the expanding growth of neurobiological research newer and more effective pharmacological treatments should be available on the near horizon.
  • Introduction -- Basic Notions on Mobility Function -- Introduction -- Components of Motor Apparatus -- Command and Control -- Spinal Functions -- Introduction -- Spinal Stabilization -- Cervical Spine and the Eye/Head Servomechanism -- Thoracic Spine and Respiratory Dynamics -- Thoracic Spine and Respiratory Dynamics -- Locomotion -- Introduction -- The Two Aspects of Locomotion -- Prehension -- Introduction -- Wrist/Hand Complex -- Humero-Radio-Ulnar Complex -- Cleido-Scapulo-Humeral Complex -- Conclusion -- Eye Mobility -- Introduction -- Three Specific Features Important to Understand -- Conclusion -- Facial Mimic -- Introduction -- Facial Superior Orbital Floor -- Facial Inferior Buccal Floor -- Masticatory Function -- Introduction -- Movements of TMJ -- Control of Mandibular Posture -- Speaking and Swallowing -- Introduction -- The Aero-Digestive Cross Way -- Swallowing -- Phonation -- Bladder and Rectum Incontinences -- Introduction -- Technical Problems and Solutions -- Command and Control -- Ejaculation and Orgasm -- Introduction -- Technical Problems af Copulation -- Motor Of Inference: The Orgasm -- Conclusions.
  • The temporal bone -- Middle ear cavity -- Middle ear contents -- Middle ear compartments -- The mastoid -- Facial Nerve -- The eustachian tube.
  • This book presents unique cases of congenital heart disease (CHD) lesions, both corrected and non-corrected, and provides a thorough overview of the diagnostic tools available. It stresses the importance of taking an appropriate history and performing a suitable physical examination, and goes on to describe electrocardiography, chest X-ray, echocardiography, computed tomography, cardiovascular magnetic resonance imaging, and catheterization to ensure the reader has the best possible guidance in the diagnosis and management of adult CHD. Comprehensive Approach to Adult Congenital Heart Disease offers an extensive account of patients and their diagnostic and treatment modalities from first presentation to latest follow-up. Consequently, this invaluable resource provides a forum for all cardiologists, cardiology trainees and medical professionals seeking further opportunities to immerse themselves in the fascinating and ever-evolving field of adult CHD.
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    Narrow band imaging : historical background and basis for its development / Shigeaki Yoshida -- An introduction to high resolution endoscopy and narrowband imaging / Kazuhiro Gono -- Getting started with high resolution endoscopy and narrowband imaging / Ajay Bansal, Prateek Sharma -- Detection of superficial cancer in the oropharyngeal and hypopharyngeal mucosal sites and the value of NBI at qualitative diagnosis / Manabu Muto, Atsushi Ochiai, Shigeaki Yoshida -- Magnifying endoscopic diagnosis of tissue atypia and cancer invasion depth in the area of pharyngo-esophageal squamous epithelium by NBI enhanced magnification image : IPCL pattern classification / Haruhiro Inoue, Makoto Kaga, Yoshitaka Sato, Satoshi Sugaya, Shin-ei Kudo -- Applications of NBI HRE and preliminary data : Barrett's esophagus and adenocarcinoma / Wouter Curvers, Paul Fockens, Jacques Bergman -- Clinical application of magnification endoscopy with NBI in the stomach and the duodenum / Kenshi Yao, Takashi Nagahama, Fumihito Hirai, Suketo Sou, Toshiyuki Matsui, Hiroshi Tanabe, Akinori Iwashita, Philip Kaye, Krish Ragunath -- Magnifying endoscopy with narrow NBI in the diagnosis of superficial gastric neoplasia and its application for ESD / Mitsuru Kaise, Takashi Nakayoshi, Hisao Tajiri -- Optical chromoeodoscopy using NBI during screening colonoscopy : its usefulness and application / Yasushi Sano, Shigeaki Yoshida -- The significance of NBI observation for inflammatory bowel diseases / Takayuki Matsumoto, Tetsuji Kudo, Mitsuo Iida -- Pharynx and esophagus atlas -- Stomach atlas -- Small intestine atlas -- Colon atlas.
  • Neuroanatomy / Jose Rafols, Gregory P. Van Stavern, and Marchello Cherchi -- Vascular diseases of the nervous system / Mark K. Borsody, Renee Bailey Van Stavern -- Seizures and epilepsy / Stephan Schuele -- Disorders of myelination / Rana Zabad -- Tumors of the nervous system / Jeffrey Raizer -- Headache and pain disorders / Jan Lewis Brandes and Susan Roberson -- Behavioral neurology and psychiatry / Randall Benson ... [et al.] -- Movement disorders / Aleksander Videnovic -- Diseases of the nerves / Jeffrey Allen -- Diseases of the muscles / Huned Patwa and Hajime Tokuno -- Infections of the nervous system / Mahmoud Rayes and Alexandros Tselis -- Development and metabolic diseases of the nervous system / Alexander Bassuk -- Systemic diseases affecting the nervous system / Casey Dunn, Jeff Wiese, and Joe Tarsia.
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    Introduction -- WHO Recommendations -- 1. Background -- 2. Anatomy of the female pelvis and natural history of cervical cancer -- 3. Health promotion: prevention, health education and counselling -- Practice sheet 1. Health education -- Practice sheet 2. Frequently asked questions (FAQs) about cervical cancer -- Practice sheet 3. How to involve men in preventing cervical cancer -- Practice sheet 4. Counselling -- Practice sheet 5. How to use male and female condoms -- 4. Screening for cervical cancer -- Practice sheet 6. Obtaining informed consent -- Practice sheet 7. Taking a history and performing a pelvic examination -- Practice sheet 8. Taking a Pap smear -- Practice sheet 9. Collecting samples for HPV DNA testing -- Practice sheet 10. Visual screening methods -- 5. Diagnosis and management of precancer -- Practice sheet 11. Colposcopy, punch biopsy and endocervical curettage -- Practice sheet 12. Cryotherapy -- Practice sheet 13. Loop electrosurgical excision procedure (LEEP) -- Practice sheet 14. Cold knife conization -- 6. Management of invasive cancer -- Practice sheet 15. Hysterectomy -- Practice sheet 16. Pelvic teletherapy -- Practice sheet 17. Brachytherapy -- 7. Palliative care -- Practice sheet 18. Pain management -- Practice sheet 19. Home-based palliative care -- Practice sheet 20. Managing vaginal discharge and fistulae at home -- Annex 1. Universal precautions for infection prevention -- Annex 2. The 2001 Bethesda system -- Annex 3. How is a test's performance measured? -- Annex 4. Flowcharts for follow-up and management of patients according to screen results -- Annex 5. Standard management of cervical precancer -- Annex 6. Cervical cancer treatment by stage -- Annex 7. Sample documents -- Annex 8. Treatment of cervical infections and pelvic inflammatory disease (PID) -- Annex 9. How to make Monsel's paste -- Glossary.
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  • Sect. I: Essential renal anatomy and physiology -- Sect. II: Investigation of renal disease -- Sect. III: Fluid and electrolyte disorders -- Sect. IV: Glomerular disease -- Sect. V: Diabetic nephropathy -- Sect. VI: Hypertension -- Sect. VII: Pregnancy and renal disease -- Sect. VIII: Hereditary and congenital diseases of the kidney -- Sect. IX: Infectious diseases and the kidney -- Sect. X: Urologic disorders -- Sect. XI: Tubulointerstitial and vascular diseases -- Sect. XII: Geriatric nephrology -- Sect. XIII: Renal disease and cancer -- Sect. XIV: Acute kidney injury -- Sect. XV: Drug therapy in kidney disease -- Sect. XVI: Chronic kidney disease and the uremic syndrome -- Sect. XVII: Dialytic therapies -- Sect. XVIII: Transplantation.
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    The cell : basic structure and function / Magnus von Knebel Doeberitz and Nicolas Wentzensen -- Basic cytogenetics and the role of genetics in cancer development / Alain Verhest and Pierre Heimann -- Cytologic screening programs / Luiz M. Collac̦o and Lucilia Zardo -- Diagnostic quality assurance in cytopathology / Marluce Bibbo and Catherine M. Keebler -- Evaluation of the sample in smears and liquid-based preparations / Marluce Bibbo and Joseph F. Nasuti -- The Bethesda system for reporting cervical cytology / Ritu Nayar, David C. Wilbur, and Diane Solomon -- Microbiology, inflammation, and viral infections / Prabodh K. Gupta and Cindy McGrath -- Benign proliferative reactions, intraepithelial neoplasia, and invasive cancer of the uterine cervix / G. Peter Vooijs, Anniek J.M. van Aspert-van Erp, and Johan Bulten -- Glandular lesions of the uterine cervix / David C. Wilbur -- Endometrial lesions, unusual tumors, and extrauterine cancer / Terence J. Colgan and C. Meg McLachlin -- Vulva, vagina, and anus / Fadi W. Abdul-Karim, Theresa M. Somrak, and Bin Yang -- Peritoneal washings and ovary / Marluce Bibbo, Moira D. Wood, and Brendan T. Fitzpatrick -- Respiratory tract / William W. Johnston and Craig E. Elson -- Alimentary tract (esophagus, stomach, small intestine, colon, rectum, anus, biliary tract) / Simon Bergman and Kim R. Geisinger -- Urinary tract / Marluce Bibbo and William H. Kern -- Central nervous system / Sandra H. Bigner and Alicia L. Carter -- Eye / Kiran F. Narsinh, Diane B. Mandell, and Ben J. Glasgow -- Cytology of soft tissue, bone, and skin / Oscar Lin and Maureen F. Zakowski -- Pleural, peritoneal, and pericardial effusions / Bernard Naylor -- Fine-needle aspiration biopsy techniques / William J. Frable -- Imaging techniques / Christopher R.B. Merritt -- Salivary glands and rare head and neck lesions / Edneia M. Tani and Lambert Skoog -- Thyroid / Hugo Galera-Davidson and Ricardo González-Cámpora -- Lymph nodes : cytomorphology and flow cytometry / Nancy A. Young and Tahseen Al-Saleem -- Breast / Reda S. Saad and Jan F. Silverman -- Mediastinum / Wai-Kuen Ng -- Kidneys, adrenals, and retroperitoneum / Ruth L. Katz and Savitri Krishnamurthy -- Liver and pancreas / Grace C.H. Yang and Liang-Che Tao -- Pediatric tumors / Jose A. Schalper -- Effects of therapy on cytologic specimens / Larry F. Kluskens -- Cytopreparatory techniques / Catherine M. Keebler and Michael Facik -- Light optical microscopy / Peter H. Bartels -- Virtual microscopy / Katharina Glatz-Krieger -- Automation in cervical cytology / David C. Wilbur and Marluce Bibbo -- Immunocytochemistry / Mamatha Chivukula and David J. Dabbs -- Molecular techniques / Lukas Bubendorf, Hans Jürgen Grote, and Kari Syrjänen.
  • In the newly updated edition of Comprehensive Cytopathology, a team of international experts provides criteria and techniques in diagnosis, testing, and new insights in cytology. This accessible guide to diagnostic investigation and screening is ideal for daily laboratory use, taking a systematic approach to helping you understand major diagnostic criteria as well as the pitfalls and limitations of cytology. Quickly find the answers you need through a consistent chapter structure.Realize every possibility. Appropriate histopathological correlations and a consideration of the possible differential diagnosis accompany the cytological findings.
  • Safely and effectively treat a full range of skin disorders with Comprehensive Dermatologic Drug Therapy, 3rd Edition! This trusted dermatology reference provides concise, complete, up-to-date guidance on today's full spectrum of topical, intralesional, and systemic drugs. Dr. Steven E. Wolverton and a team of leading international experts clearly explain what drugs to use, when to use them, and what to watch out for. Prescribe with confidence thanks to quick-access summaries of indications/contraindications, dosage guidelines, drug interactions, drug monitoring guidelines, adverse effects, and treatment protocols.Assess your knowledge and prepare for certification or recertification with more than 800 review questions and answers throughout the book.Contain costs and meet patient expectations with purchase information provided for major drugs.Quickly evaluate drug options for each disease discussed using a highly detailed, disease-specific index.
  • Comprehensive Guide to Education in Anesthesia is the first single-source volume on the current practice of teaching and learning in this specialty which has long been at the forefront of innovation in medical education. It is edited by one of the great anesthesiology educators in the United States and brings together contributions from leading educators from across the US covering all aspects of anesthesiology education, from medical school and post-graduate training to board certification and continuing medical education. Topics include best educational practices, closed claim analysis, giving feedback to superiors, residency and fellowship training and requirements, maintenance of certification, the role of simulation, interacting with other specialties, community and global outreach, and more. The book conveys the unique nature of the specialty and is aimed at medical students contemplating a career in anesthesiology, residents and fellows, educators, and administrators.
  • This comprehensive guide answers commonly asked questions about neurosurgical conditions related to brain and spinal cord. Comprehensive Guide to Neurosurgical Conditions fills the gap which arises after a diagnosis is made on the loved one, explaining the basics of neurosurgical diseases and their management. Comprehensive Guide to Neurosurgical Conditions, looks at the Neurosurgical team, the Intensive Care Unit and the basic as well as the emergency neurosurgical procedures in a comprehensive and concise matter. Comprehensive Guide to Neurosurgical Conditions, which is part of a book set including Emergency Approaches to Neurosurgical Conditions, delves into different kinds of brain surgeries, tumors and the management of stroke in chapters written by reputed neurosurgeons worldwide, to help the physicians, the patients and their families cope with all aspects of neurosurgery.
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  • Basic science -- Fertilization and embryogenesis: meiosis, fertilization, implantation, embryonic development, sexual differentiation -- Reproductive genetics: gene structure, mutation, molecular tools, types of inheritance, counseling issues, oncogenes -- Reproductive anatomy: gross and microscopic, clinical correlations -- Reproductive endocrinology: neuroendocrinology, gonadotropins, sex steroids, prostaglandins, ovulation, menstruation, hormone assay -- Evidence-based medicine and clinical epidemiology -- Medical-legal risk management -- Comprehensive evaluation of the female -- History, physical examination, and preventive health care: general, gynecologic, and psychosocial history and examination, health care maintenance, disease prevention -- The interaction of medical diseases and female physiology -- Emotional aspects of gynecology: depression, anxiety, PTSD, eating disorders, substance abuse, "difficult" patients, sexual function, rape, intimate partner violence, and grief -- Endoscopy: hysteroscopy and laparoscopy: indications, contraindications and complications -- General gynecology -- Congenital abnormalities of the female reproductive tract: anomalies of the vagina, cervix, uterus, and adnexa -- Pediatric and adolescent gynecology: gynecologic examination, infections, trauma, pelvic mass, precocious puberty -- Family planning: contraception, sterilization, and pregnancy termination -- Menopause and care of the mature woman: endocrinology, consequences of estrogen deficiency, effects of hormone replacement therapy, and treatment regimens -- Breast diseases: diagnosis and treatment of benign and malignant disease -- Spontaneous and recurrent abortion: etiology, diagnosis, treatment -- Ectopic pregnancy: etiology, pathology, diagnosis, management, fertility prognosis -- Benign gynecologic lesions: vulva, vagina, cervix, uterus, oviduct, ovary, ultrasound imaging of pelvic structures -- Endometriosis: etiology, pathology, diagnosis, management -- Anatomic defects of the abdominal wall and pelvic floor: abdominal and inguinal hernias, cystocele, urethrocele, enterocele, rectocele, uterine and vaginal prolapse: diagnosis and management -- Urogynecology: physiology of micturition, voiding dysfunction, urinary incontinence, urinary tract infections, and painful bladder syndrome -- Anal incontinence: diagnosis and management -- Infections of the lower and upper genital tracts: vulva, vagina, cervix, toxic shock syndrome, endometritis, and salpingitis -- Preoperative counseling and management: woman evaluation, informed consent, infection prophylaxis, and avoidance of complications -- Postoperative counseling and management: fever, respiratory, cardiovascular, thromboembolic, urinary tract, gastrointestinal, wound, and operative site complications; neurologic injury; psychological sequelae -- Gynecologic oncology -- Molecular oncology in gynecologic cancer: immunologic response, cytokines, oncogenes, and tumor suppressor genes -- Principles of radiation therapy and chemotherapy in gynecologic cancer: basic principles, uses, and complications -- Intraepithelial neoplasia of the lower genital tract (cervix, vulva): etiology, screening, diagnostic techniques, management -- Malignant diseases of the cervix: microinvasive and invasive carcinoma: diagnosis and management -- Neoplastic diseases of the vulva: lichen sclerosus, intraepithelial neoplasia, Paget's disease, and carcinoma -- Malignant diseases of the vagina: intraepithelial neoplasia, carcinoma, sarcoma -- Neoplastic diseases of the uterus: endometrial hyperplasia, endometrial carcinoma, and sarcoma: diagnosis and management -- Neoplastic diseases of the ovary: screening, benign and malignant epithelial and germ cell neoplasms, sex-cord stromal tumors -- Fallopian tube and primary peritoneal cancer: causes, diagnosis, natural history, and treatment -- Gestational trophoblastic disease: hydatidiform mole, nonmetastatic and metastatic gestational trophoblastic tumor: diagnosis and management -- Reproductive endocrinology and infertility -- Primary and secondary dysmenorrhea, premenstrual syndrome, and premenstrual dysphoric disorder: etiology, diagnosis, management -- Abnormal uterine bleeding: ovulatory and anovulatory dysfunctional uterine bleeding: management of acute and chronic excessive bleeding -- Primary and secondary amenorrhea and precocious puberty: etiology, diagnostic evaluation, management -- Hyperprolactinemia, galactorrhea, and pituitary adenomas: etiology, differential diagnosis, natural history, management -- Hyperandrogenism: physiology, etiology, differential diagnosis, management -- Infertility: etiology, diagnostic evaluation, management, prognosis.
  • Part I. General aspects of alcohol toxicity, consumption, and disease -- Part II. Damage/disease: -- General aspects of pathology -- Organ damage -- Cells, pathways, interactions, processes -- Part III. Selective methods used in alcohol research -- Index.
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    v.1, Systems intervention ; v.2, Syndromes & special areas ; v.3, Extended applications & issues ;
  • Analytical techniques -- General aspects of iodine sources and intakes in the diet, main routes of iodine metabolism and metabolic roles -- Pathological aspects of iodine deficiency -- Prevention and treatment of iodine deficiency disorders -- Damage and disease due to iodine toxicity -- Radiodine in the non-iodine deficient subject -- Other causes of hypothyroidism -- Geographical aspects of iodine deficiency disorders.
  • Nationally recognized experts equip the reader with practical, actionable guidance on all of the challenges faced every day in hospital medicine, making it easier to provide optimal care for every patient in an efficiently managed unit.
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    1. A Short History of the Study of Hypertension -- 2. Blood Pressure in Westernized and Isolated Populations -- 3. Regional Differences in Blood Pressure in Developed Countries -- 4. Early-Life Influences on Blood Pressure -- 5. Blood Pressure and the Risks of Cardiovascular Disease and Stroke -- 6. Lifestyle and Blood Pressure -- 7. Dietary Fats and Blood Pressure --8. Effects of Dietary Patterns -- 9. Renovascular Hypertension: Pathophysiology and Evaluation of Renal Function -- 10. Left Ventricular Physiology and Pathophysiology in Hypertension --11. Hemodynamics of Hypertension --12. The Arterial System in Human Hypertension -- 13. Resistance Vessels in Hypertension -- 14. The Endothelium in Hypertension: Assessment and Clinical Aspects of Micro- and Macrovascular Function -- 15. Vascular Remodeling and Rarefaction in Hypertension -- 16. The RhoA/Rho-Kinase Signaling Pathway in Vascular Smooth Muscle Contraction: Biochemistry, Physiology, and Pharmacology -- 17. Matrix Metalloproteinases and the Extracellular Matrix -- 18. Cell Membranes (Blood Cell and Platelet Membranes in Human Essential Hypertension) -- 19. Arterial and Venous Function in Hypertension -- 20. Sodium Pumps -- 21. Platelet and Coagulation Abnormalities -- 22. Role of Cytokines and Inflammation in Hypertension -- 23. Role of the Kidney in Hypertension -- 24. The Baroreflex in the Pathogenesis of Hypertension -- 25. Central Nervous System Control of Blood Pressure -- 26. Aldosterone and Other Steroids -- 27. The Renin-Angiotensin System in the Pathophysiology of Essential Hypertension -- 28. The Endothelin System -- 29. Nitric Oxide -- 30. Reactive Oxygen Species, Oxidative Stress, and Vascular Biology in Hypertension -- 31. Natriuretic Peptides -- 32. Other Peptide and Related Systems including Substance P, Calcitonin Gene-Related Peptide, and Serotonin -- 33. Multiple Roles of Eicosanoids in Blood Pressure Regulation -- 34. Role of Sex Steroids in Hypertension -- 35. Genetic Approaches to Hypertension: Relevance to Human Hypertension -- 36. Monogenic Forms of Human Hypertension -- 37. Therapeutic Potential of Systemic Gene Transfer Strategy for Hypertension and Cardiovascular Disease -- 38. Pathophysiology of Obesity-Induced Hypertension and Target Organ Damage -- 39. Exercise and Hypertension -- 40. Electrolyte Intake and Human Hypertension -- 41. Alcohol Intake and Blood Pressure -- 42. Psychosocial Stress and Hypertension -- 43. Overview of Assessment and Investigation of Hypertension: A Pragmatic Practical Approach -- 44. Blood Pressure Measurement -- 45. Out-of-Office Blood Pressure Monitoring -- 46. Cardiologic Investigation of the Hypertensive Patient -- 47. The Effects of Hypertension on the Structure of Human Resistance Vessels -- 48. The Brain in Hypertension -- 49. Kidney Disease and Hypertension -- 50. Hypertensive Heart Disease -- 51. The Eye in Hypertension -- 52. Hypertension in Children and Adolescents -- 53. Hypertension in the Elderly -- 54. Hypertension in Pregnancy -- 55. Insulin Resistance and Diabetes in Hypertension -- 56. Hypertension in Renal Failure -- 57. Hypertension in Racial and Ethnic Minorities -- 58. Hyperadrenergic and Labile Hypertension -- 59. Resistant Hypertension -- 60. Perioperative Hypertension: Preparing the Hypertensive Patient for Anesthesia for Surgery -- 61. Hypertension in the Context of Acute Myocardial Infarction and Percutaneous Coronary Interventions -- 62. Hypertension in Patients with Concomitant Cardiac Disorders -- 63. Hypertensive Urgencies and Emergencies -- 64. Renovascular Hypertension -- 65. Proteinuria -- 66. Renin-Secreting Tumors and Other Renin-Secreting States -- 67. Primary Hyperaldosteronism and Other Forms of Mineralocorticoid Hypertension -- 68. Glucocorticoid Hypertension -- 69. Cushing's Syndrome and Human Glucocorticoid Hypertension -- 70. Oral Contraceptives, Hormone Replacement Therapy, and Hypertension -- 71. Drug-Induced Hypertension -- 72. Catecholamines, Pheochromocytoma, and Hypertension: Genomic Insights -- 73. Nonadrenal Endocrine Hypertension -- 74. Coarctation of the Aorta -- 75. Hypertension Due to Central Nervous System Dysfunction -- 76. Sleep Apnea and Hypertension -- 77. Diuretics -- 78. Beta Blockers in Hypertension -- 79. Calcium Antagonists -- 80. Angiotensin-Converting Enzyme Inhibitors -- 81. Angiotensin II Receptor Blockers -- 82. Alpha Adrenoreceptor Antagonists -- 83. Centrally Acting Agents -- 84. Vasodilators -- 85. Novel Drug Treatments for Hypertension -- 86. Fixed Low-Dose Antihypertensive Therapy -- 87. Interactions Between Antihypertensive Drugs and Other Medications -- 88. Lipid-Lowering Therapy -- 89. Antithrombotic Therapy in Hypertension -- 90. Control of Blood Glucose and Insulin Resistance -- 91. Target Blood Pressure in Hypertension Treatment: The J-shaped Curve Controversy -- 92. Adherence, Quality of Life, Cost Effectiveness, and the Role of the Pharmacist -- 93. Nonpharmacologic Management of Hypertension -- 94. Multidisciplinary Management of Hypertension and the Role of the Nurse -- 95. World Health Organization/International Society of Hypertension (WHO/ISH): Hypertension Guidelines and Statements -- 96. Treatment Guidelines: The United States JNC7 -- 97. The 2003 Guidelines for the Management of Hypertension of the European Society of Hypertension and European Society of Cardiology -- 98. Treatment Guidelines: The Developing World.
  • Part One. Lipid testing -- Atherosclerosis and clinical atherosclerosis -- From cholesterol to lipoproteins and apolipoproteins -- Lipid testing -- Lipid profiles -- Lipid testing and prediction of coronary heart disease -- Lipid risk factors in prediction of coronary heart disease - is any one factor best? -- Part Two. Lipid management -- Goals of lipid management -- Cholesterol lowering and prevention of CHD -- Cholesterol goals in current guidelines -- Lipid management in clinical practice -- Drugs for lipid management -- Diabetic dyslipidaemia -- LDL apheresis -- Lipid-modifying agents under development.
  • v. 1. Global perspective / volume editor, Peter D. Kennewell -- v. 2. Strategy and drug research / volume editor, Walter H. Moos -- v. 3. Drug discovery technologies / volume editor, Hugo Kubinyi -- v. 4. Computer-assisted drug design / volume editor, Jonathan S. Mason -- v. 5. ADME-Tox approaches / volume editors, Bernard Testa and Han van de Waterbeemd -- v. 6. Therapeutics areas I: central nervous system, pain, metabolic syndrome, urology, gastrointestinal and cardiovascular / volume editor, Michael Williams -- v. 7. Therapeutic areas II: cancer, infectious diseases, inflammation & immunology and dermatology / volume editors, Jacob J. Plattner & Manoj C. Desai -- v. 8. Case histories and cumulative subject index / volume editors, John B. Taylor & David J. Triggle.
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    v. 1. General principles / volume editor, Peter D. Kennewell -- v. 2. Enzymes & other molecular targets / volume editor, Peter G. Sammes -- v. 3. Membranes & receptors / volume editor, John C. Emmett -- v. 4. Quantitative drug design / volume editor, Christopher A. Ramsden -- v. 5. Biopharmaceutics / volume editor, John B. Taylor -- v. 6. Cumulative subject index & drug compendium / volume editor, Colin J. Drayton.
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  • Anatomy -- Physiology -- Pathology and radiology -- Neurology -- Neurosurgery -- Critical care -- Glossary of abbreviations.
  • 1. What is a Hospitalist? -- 2. Pediatric Hospitalists: Efficiency and Quality of Care -- 3. Hospitalist Models of Care: Organization and Compensation -- 4. Quality of Care and Patient Satisfaction -- 5. Patient Safety and Medical Errors in Pediatric Hospitals -- 6. Infection Control for Pediatric Hospitals -- 7. Evidence-Based Medicine -- 8. Clinical Practice Guidelines -- 9. Approach to the Hospitalized Patient and Family -- 10. Hospitalist as Patient Advocate -- 11. Spiritual Care of the Hospitalized Child and Family -- 12. Pediatric Palliative, End-of-Life, and Bereavement Care -- 13. Transitions of Care in Hospitalized Children -- 14. Medical Consultation and Co-management -- 15. Transport Medicine for Hospitalists -- 16. Finances -- 17. Discharge planning, follow-up, payer relations, utilization management, home care -- 18. Ethics -- 19. Legal Issues: risk management, malpractice -- 20. Clinical Research -- 21. Protection of Patients, Research Subjects, and Confidentiality / IRBs and HIPPA -- 22. Medical Education; Inpatient Medical Education -- 23. Professional Organizations -- 24. Future Development of the Field -- 25. Abdominal Mass -- 26. Abdominal Pain -- 27. Acidosis -- 28. Altered Mental Status -- 29. Chest Pain -- 30. Cyanosis -- 31. Diarrhea -- 32. FTT -- 33. Fever -- 34. GI Bleeding -- 35. Hypertension -- 36. Hypoglycemia -- 37. Hyoptension/ Shock -- 38. Hypoxemia -- 39. Irritability/Intractable Crying -- 40. Limp/Joint Swelling -- 41. Lymphandenopathy/Adenitis -- 42. Mouth Pain/Lesions -- 43. Neck Pain -- 44. Petechiae/Purpura -- 45. Respiratory Distress (Wheezing, Stridor, SOB, Cough, Tachypnea) -- 46. Syncope -- 47. Vomiting -- 48. Delivery room medicine (NALS, premies, Apgars) -- 49. Term newborn (newborn screen, hips, hearing, hep B) -- 50. Birth Injury -- 51. Congenital anomalies -- 52. Respiratory Distress/TTN -- 53. Congenital and Perinatal Infections/Sepsis -- 54. Hypoglycemia, IDM -- 55. Hyperbilirubinemia -- 56. Neonatal abstinence/withdrawal -- 57. Dehydration -- 58. Electrolyte abnormalities (Na, K, Ca, Mg) -- 59. Antimicrobial Agents -- 60. Fever -- 61. FUO -- 62. Fever and Rash -- 63. CNS Infections -- 64. URTI -- 65. Neck and Oral Cavity Infections -- 66. Middle RTI and Bronchiolitis -- 67. Pneumonia -- 68. GI Infections -- 69. UTI -- 70. Bone, Joint, Soft-Tissue Infections -- 71. Catheter-related infections -- 72. HIV -- 73. Immunocompromised host -- 74. Apnea, ALTE, OSA -- 75. Asthma -- 76. Aspiration -- 77. BPD -- 78. Cystic Fibrosis -- 79. Airway Foreign Body -- 80. PFTs, and other tests of resp physiology -- 81. The Cardiac Exam -- 82. Approach to ECGs -- 83. Congenital Heart Disease -- 84. Endocarditis -- 85. Myocarditis/Cardiomyopathies -- 86. Pericarditis -- 87. Acute Rheumatic Fever -- 88. Diabetes Mellitus -- 89. Thyroid Disorders -- 90. Hypopituitarism/DI -- 91. Disorders of Calcium Metabolism -- 92. Adrenal Disorders -- 93. Biliary Disease -- 94. Constipation/encopresis -- 95. Gastritis and Ulcer Disease -- 96. Gastric emptying disorders -- 97. Hepatic Disorders -- 98. Inflammatory Bowel Disease -- 99. Malnutrition -- 100. Pancreatitis -- 101. Feeding Issues -- 102. Kawasaki Disease -- 103. Henoch Schonlein Purpura -- 104. Juvenile Dermatomyositis -- 105. Juvenile Rheumatoid Arthritis -- 106. Postinfectious Arthridites -- 107. Systemic Lupus Erythematosus -- 108. Acute renal failure -- 109. Chronic renal insufficiency/failure -- 110. Glomerulonephritis -- 111. Hemolytic Uremic Syndrome -- 112. Interstitial Nephritis -- 113. Nephrotic Syndrome -- 114. Renal Tubular Acidosis -- 115. Renal Vein Thrombosis -- 116. Anemia -- 117. Sickle Cell Anemia -- 118. Neutropenia -- 119. Thrombocytopenia -- 120. Disorders of Coagulation and Thrombosis -- 121. Transfusion Medicine and Blood Products -- 122. Emergencies -- 123. Initial care/management of common tumors -- 124. Fever and neutropenia, other complications of chemotherapy/radiation -- 125. Issues surrounding bone marrow transplant patients (GVHD) -- 126. Seizure disorders and status epilepticus -- 127. Headache -- 128. Weakness/hypotonia -- 129. Stroke and aneurysms -- 130. Common chromosomal disorders -- 131. Hyperammonemia (urea cycle defects) -- 132. Hypoglycemia -- 133. Metabolic acidosis -- 134. Anaphylaxis -- 135. Medication allergies and desensitization -- 136. Immunodeficiencies -- 137. IVIG -- 138. Gen: obstruction -- 139. Gen :abdominal Pain/Acute Abd -- 140. Gen: hernias -- 141. Gen: trauma -- 142. ENT -- 143. Neurosurgery -- 144. Ophtho -- 145. Orthopedics -- 146. Plastics: burns -- 147. Thoracic: Pneumothorax, Pneumomediastinum, Chest tubes -- 148. Urology -- 149. Physical Exam Findings: lumps and bumps -- 150. Purpura -- 151. Vesicles and Bullae -- 152. Psoriasis -- 153. Vascular Anomalies -- 154. Scabies and Lice -- 155. Atopic Dermatitis -- 156. Cellulitis and Erysipelas -- 157. Staphylococcal Scalded Skin Syndrome -- 158. Ecthyma Gangrenosum -- 159. Drug-associated Skin Rashes -- 160. Erythema Mulitforme -- 161. Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis -- 162. Skin Diseases in Immunosuppressed Hosts -- 163. Erythrodermolysis Bullosa -- 164. Transplacentally Acquired Dermatoses of the Newborn -- 165. Depression -- 166. Suicide -- 167. Somataform disorders, diff dx of depression in hospitalized children -- 168. Agitation in hospitalized children -- 169. New onset psychosis -- 170. Eating Disorders -- 171. Sexually Transmitted Diseases -- 172. Menstrual Disorders: DUB, Amenorrhea, Menorrhagia -- 173. Shaken baby syndrome -- 174. Use of imaging/testing ₆ skeletal survey, ophtho exam, CT -- 175. Injuries, signs/symptoms concerning for non-accidental trauma -- 176. Munchausen-by-proxy syndrome -- 177. Legal issues -- 178. Stabilization of poisoned patients -- 179. OTC and Diabetic Agents -- 180. Chemical Exposures -- 181. Lead and other metals, Chelation -- 182. Drugs of Abuse -- 183. Withdrawal syndromes -- 184. Burns, Smoke Inhalation, Carbon Monoxide -- 185. Heat Disorders -- 186. Hypothermia, Cold Disorders -- 187. Drowning, Near Drowning -- 188. Animal Bites, Rabies, Human Bites -- 189. Envenomations -- 190. Infant Botulism -- 191. Nuclear/Biological/Chemical Terrorism -- 192. Introduction: Definitions -- 193. Special approach to Complex Care Children -- 194. Common reasons for admission -- 195. Technology: enterostomy tubes, vascular access, shunts -- 196. DNR and other special issues -- 197. Sedation and Pain Management -- 198. Patient Preparation for Imaging -- 199. LP -- 200. Cath urine -- 201. ABG -- 202. IV -- 203. intraosseous -- 204. CVL -- 205. UAL, UVL -- 206. Phlebotomy -- 207. Trach change -- 208. Intubation -- 209. Noninvasive Ventilation -- 210. Thoracentesis -- 211. Paracentesis -- 212. Arthrocentesis -- 213. VP shunt check -- 214. VP tap -- 215. Gross/Fine Motor, Social, Language.
  • This book brings you a state-of-the-art comprehensive review on every clinical condition encountered in pediatric nephrology in one concise, clinically focused text. International experts provide you with the latest on epidemiology, diagnosis, investigations, management, and prognosis for a full range of pediatric kidney disorders. A full-color, highly visual, meticulously crafted format, makes this material remarkably easy for you to access and apply.
  • Since the first edition of this book was published in 2004, the management of congenital heart disease has continued to evolve at a rapid pace. Not only have new operations been developed and expanded, such as the intra/extracardiac conduit Fontan and the double root translocation for corrected transposition, but in addition, diagnostic methods-particularly cardiac CT and MRI-have been dramatically transformed. Understanding of the genetic basis of congenital heart disease and the embryology of cardiac development has progressed even more rapidly. What has not changed is that optimal.
  • Skull base anatomy and CSF rhinorrhea / A. Lam, E. Holbrook -- Pathophysiology of iatrogenic and traumatic skull base injury / S.T. Gray, A.W. Wu -- Grafting materials in skull base reconstruction / K.K. Prickett, S.K. Wise -- Free graft techniques in skull base reconstruction / J.Y. Ting, R. Metson -- Nasoseptal flap / C.D. Pinheiro-Neto -- Sphenopalatine-derived pedicled flaps / J.D. Suh, A.G. Chiu -- Anteriorly based pedicled flaps for skull base reconstruction / J.C. Meier, B.S. Bleier -- Pedicled extranasal flaps in skull base reconstruction / G.G. Kim ... [et al.] -- Microvascular free flaps in skull base reconstruction / M.W. Herr, D.T. Lin -- Spontaneous cerebrospinal fluid leak and management of intracranial pressure / Z.M. Soler, R.J. Schlosser -- Endoscopic reconstruction of frontal, cribiform, and ethmoid skull base defects / R.J. Harvey -- Chin : planum, tubercular, sellar, and clival defects / C.C. Wei, J.N. Palmer -- Quality control approach to cerebrospinal fluid leaks / C.H. Snyderman, P.A. Gardner -- Postoperative care following skull base reconstruction / V.R. Ramakrishnan, A. Waziri -- Complications of skull base reconstruction / M. Chaaban, B.A. Woodworth -- Prevention and management of complications after treatment for skull base tumors : a multidisciplinary approach / J.W. Jang, A.W. Chan -- Novel techniques and the future of skull base reconstruction / J.C. Meier, B.S Bleier.
  • Part I. Psychiatric Relevance and Implications of AIDS Psychiatry -- History of AIDS Psychiatry: A Biopsychosocial Approach-Paradigm and Paradox -- HIV/AIDS at 25: History, Epidemiology, Clinical Manifestations, and Treatment -- Psychoneuroimmunology and HIV -- Epidemiology of Psychiatric Disorders Associated with HIV and AIDS -- Sociocultural Factors Influencing the Transmission of HIV/AIDS in the United States: AIDS and the Nation's Prisons -- Part II. Comprehensive AIDS Psychiatric Assessment -- A Biopsychosocial Approach to Psychiatric Consultation in Persons with HIV and AIDS -- Neuropsychological Evaluation -- Part III. Psychiatric Disorders and HIV Infection -- Substance Use Disorders - The Special Role in HIV Transmission -- Mood Disorders -- HIV-Associated Neurocognitive Disorders -- Anxiety Disorders -- Psychotic Disorders and Severe Mental Illness -- The Role of Personality in HIV Risk Behaviors: Implications for Treatment -- Part IV. Unique Psychiatric Manifestations of HIV Infection -- Distress in Persons with HIV and AIDS -- Insomnia and HIV: A Biopsychosocial Approach -- Fatigue and HIV -- Unique Manifestations of HIV-Associated Dementia -- Suicide -- Part V. Neuropathologic Manifestations of HIV Infection -- HIV and the Central Nervous System -- Neurological Complications of HIV in the Spinal Cord and Peripheral Nervous System -- Part VI. Risk Behaviors, HIV Transmission, and Adherence -- The Role of Psychiatric Disorders in HIV Transmission and Prevention -- Psychiatric Aspects of Adherence to Medical Care and Treatment for HIV/AIDS -- Homelessness and HIV Risk and Prevention -- Part VII. AIDS Psychiatry through the Life Cycle -- Childhood and Adolescence -- Young Adulthood and Serodiscordant Couples -- Older Age and HIV Infection -- Part VIII. AIDS Psychiatric Treatment and Psychotherapeutic Modalities -- Psychiatric Interventions -- Social Service Interventions -- Nursing Support -- Palliative and Spiritual Care of Persons with HIV and AIDS -- Special Settings: Psychiatric Facilities, Nursing Homes, Correctional Facilities, and Homeless Outreach -- Psychopharmacologic Treatment Issues in AIDS Psychiatry -- Part IX. AIDS Psychiatry and Comorbid Medical Conditions -- Hepatitis C and HIV Coinfection -- HIV-Associated Nephropathy, End-Stage Renal Disease, Dialysis, and Kidney Transplant -- Endocrine Comorbidities in Persons with HIV -- Lipodystrophy, Metabolic Disorders, and Cardiovascular Disorders in Persons with HIV -- Overview of HIV-Associated Comorbidities -- Part X. Ethical and Health Policy Aspects of AIDS Psychiatry -- Burnout, Occupational Hazards, and Health Care Workers with HIV -- End-of-Life Issues -- Ethical Issues, Advance Directives, and Surrogate Decision-Making -- Health Services and Policy Issues in AIDS Psychiatry.
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  • Part I. Introduction to simulation -- Part II. Simulation modalities and technologies -- Part III. Simulation for healthcare disciplines -- Part IV. Professional development in simulation -- Part V. Program development in simulation -- Appendices -- Index.
  • Pt. 1. Medical approaches -- Pt. 2. Interventional approaches: anatomy and physiology of pain -- Pt. 3. Interventional approaches: neural blockade and neurolysis blocks -- Pt. 4. Interventional approaches: neuromodulation -- Pt. 5. Integrative approaches.
  • This book provides all the state-of-the-art coverage you need on both operative and non-operative treatments for different clinical pathologies of the aging spine. Dr. James Yue and a team of talented, pioneering orthopedic surgeons and neurosurgeons cover hot topics like minimally invasive fusion, dynamic stabilization, state-of-the-art intraspinous and biologic devices, and more, in print. Master the very latest techniques and technologies through detailed step-by-step surgical instructions, tips, and pearls. Stay current on the state-of-the-art in intraspinous and biologic devices-such as Stent (Alphatec) and Optimesh Spineology; thoracic techniques-kyphoplasty, vertebroplasty, and spacers; and conservative treatment modalities-including injection therapies, acupuncture, and yoga. Make expert-guided decisions on techniques and device selection using the collective clinical experience of pioneering editors and contributors. Identify the advantages and disadvantages for the full range of available microsurgical and endoscopic techniques for management of cervical, thoracic, and lumbar spine pathology-minimally invasive fusion, reconstruction, decompression, and dynamic stabilization.
  • This 2nd Edition delivers in-depth, clinically focused coverage of all aspects of vascular surgery in an exceptionally well-designed single reference. Each disease chapter follows the same consistent format, for quick consultation and better comprehension. The revised 2nd Edition features several new chapters, increased endovascular treatment coverage, and updated data from the latest trials, bringing you the newest advances from the field. More than 1,000 photographs, line drawings and tables-including many revised illustrations now in color-depict key concepts and procedures. With its practical user friendly approach-and online access through Expert Consult functionality-this resource offers convenient access to complete guidance.
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    Psychiatry by the dumpster -- H2O under the bridge -- A Greek tragedy -- With any luck -- Eternity drive -- Onychophagia.
  • This book introduces the reader to modern computational and statistical tools for translational epigenomics research. Over the last decade, epigenomics has emerged as a key area of molecular biology, epidemiology and genome medicine. Epigenomics not only offers us a deeper understanding of fundamental cellular biology, but also provides us with the basis for an improved understanding and management of complex diseases. From novel biomarkers for risk prediction, early detection, diagnosis and prognosis of common diseases, to novel therapeutic strategies, epigenomics is set to play a key role in the personalized medicine of the future. In this book we introduce the reader to some of the most important computational and statistical methods for analyzing epigenomic data, with a special focus on DNA methylation. Topics include normalization, correction for cellular heterogeneity, batch effects, clustering, supervised analysis and integrative methods for systems epigenomics. This book will be of interest to students and researchers in bioinformatics, biostatistics, biologists and clinicians alike. Dr. Andrew E. Teschendorff is Head of the Computational Systems Genomics Lab at the CAS-MPG Partner Institute for Computational Biology, Shanghai, China, as well as an Honorary Research Fellow at the UCL Cancer Institute, University College London, UK.
  • Computational biology 2010
    Springer Protocols
    Sequencing and genome assembly using next-generation technologies -- RNA structure prediction -- Normalization of gene-expression microarray data -- Prediction of transmembrane topology and signal peptide given a protein's amino acid sequence -- Protein structure modeling -- Template-based protein structure modeling -- Automated protein NMR structure determination in solution -- Computational tools in protein crystallography -- 3-D structures of macromolecules using single-particle analysis in eman -- Computational design of chimeric protein libraries for directed evolution -- Mass spectrometric protein identification using the global proteome machine -- Unbiased detection of posttranslational modifications using mass spectrometry -- Protein quantitation using mass spectrometry -- Modeling experimental design for proteomics -- A functional proteomic study of the Trypanosoma brucei nuclear pore complex: An informatic strategy -- Inference of signal transduction networks from double causal evidence -- Reverse engineering gene regulatory networks related to quorum sensing in the plant pathogen pectobacterium atrosepticum -- Parameter inference and model selection in signaling pathway models -- Genetic algorithms and their application to in silico evolution of genetic regulatory networks.
  • This greatly expanded 2nd edition provides a practical introduction to - data processing with Linux tools and the programming languages AWK and Perl- data management with the relational database system MySQL, and- data analysis and visualization with the statistical computing environment R for students and practitioners in the life sciences. Although written for beginners, experienced researchers in areas involving bioinformatics and computational biology may benefit from numerous tips and tricks that help to process, filter and format large datasets. Learning by doing is the basic concept of this book. Worked examples illustrate how to employ data processing and analysis techniques, e.g. for - finding proteins potentially causing pathogenicity in bacteria, - supporting the significance of BLAST with homology modeling, or- detecting candidate proteins that may be redox-regulated, on the basis of their structure. All the software tools and datasets used are freely available. One section is devoted to explaining setup and maintenance of Linux as an operating system independent virtual machine. The author's experiences and knowledge gained from working and teaching in both academia and industry constitute the foundation for this practical approach.
  • Identification of Relevant Genes from Microarray Experiments based on Partial Least Squares Weights: Application to Cancer Genomics -- Geometric Biclustering and Its Applications to Cancer Tissue Classification Based on DNA Microarray Gene Expression Data -- Statistical Analysis on Microarray Data: Selection of Gene Prognosis Signatures -- Agent-Based Modeling of Ductal Carcinoma In Situ: Application to Patient-Specific Breast Cancer Modeling -- Multicluster Class-Based Classification for the Diagnosis of Suspicious Areas in Digital Mammograms -- Analysis of Cancer Data Using Evolutionary Computation -- Analysis of Population-Based Genetic Association Studies Applied to Cancer Susceptibility and Prognosis -- Selected Applications of Graph-Based Tracking Methods for Cancer Research -- Recent Advances in Cell Classification for Cancer Research and Drug Discovery -- Computational Tools and Resources for Systems Biology Approaches in Cancer -- Laser Speckle Imaging for Blood Flow Analysis -- The Challenges in Blood Proteomic Biomarker Discovery.
  • An overview of the computational analyses and discovery of transcription factor binding sites -- Components and mechanisms of regulation of gene expression -- Regulatory regions in DNA: promoters, enhancers, silencers, and insulators -- Three-dimensional structures of DNA-bound transcriptional regulators -- Identification of promoter regions and regulatory sites -- Motif discovery using expectation maximization and Gibbs' sampling -- Probabilistic approaches to transcription factor binding site prediction -- The motif tool assessment platform (MTAP) for sequence-based transcription factor binding site prediction tools -- Computational analysis of ChIP-seq data -- Probabilistic peak calling and controlling false discovery rate estimations in transcription factor binding site mapping from ChIP-seq -- Sequence analysis of chromatin immunoprecipitation data for transcription factors -- Inferring protein-DNA interaction parameters from SELEX experiments -- Kernel-based identification of regulatory modules -- Identification of transcription factor binding sites derived from transposable element sequences using ChIP-seq -- Target gene identification via nuclear receptor binding site prediction -- Computing chromosome conformation -- Large-scale identification and analysis of C-proteins -- Evolution of cis-regulatory sequences in drosophila -- Regulating the regulators: modulators of transcription factor activity -- Annotating the regulatory genome -- Computational identification of plant transcription factors and the construction of the plant TFDB database -- Practical computational methods for regulatory genomics: a cisGRN-lexicon and cisGRN-browser for gene regulatory networks -- Reconstructing transcriptional regulatory networks using three-way mutual information and Bayesian networks -- Computational methods for analyzing dynamic regulatory networks
  • This book focuses on applications of compound library design and virtual screening to expand the bioactive chemical space, to target hopping of chemotypes to identify synergies within related drug discovery projects or to repurpose known drugs, to propose mechanism of action of compounds, or to identify off-target effects by cross-reactivity analysis. Both ligand-based and structure-based in silico approaches, as reviewed in this book, play important roles for all these applications. Computational chemogenomics is expected to increase the quality and productivity of drug discovery and lead.
  • Computational biology: are we there yet? / Gary Peltz -- Statistical theory in QTL mapping / Benjamin Yakir, Anne Pisanté, and Ariel Darvasi -- Haplotype-based computational genetic analysis in mice / Jianmei Wang and Gary Peltz -- Haplotype structure of the mouse genome / Jianmei Wang ... [et al.] -- SNP discovery and genotyping: methods and applications / Jun Wang ... [et al.] -- Genetic and genomic approaches to complex lung disease using mouse models / Michael J. Holtzman, Edy Y. Kim, and Jeffrey D. Morton -- Murine models of osteoporosis / Robert F. Klein -- Murine models of substance and alcohol dependence: unraveling genetic complexities / Kim Cronise and John C. Crabbe -- Murine models of alcoholism: from QTL to gene / Chris Downing, Beth Bennett, and Thomas E. Johnson -- HLA polymorphism and disease susceptibility / -- Henry A. Erlich -- Asthma genetics: a case study / William Cookson.
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  • Recent advances in development of sequencing technology has resulted in a deluge of genomic data. In order to make sense of this data, there is an urgent need for algorithms for data processing and quantitative reasoning. An emerging in silico approach, called computational genomic signatures, addresses this need by representing global species-specific features of genomes using simple mathematical models. This text introduces the general concept of computational genomic signatures, and it reviews some of the DNA sequence models which can be used as computational genomic signatures. The text takes the position that a practical computational genomic signature consists of both a model and a measure for computing the distance or similarity between models. Therefore, a discussion of sequence similarity/distance measurement in the context of computational genomic signatures is presented. The remainder of the text covers various applications of computational genomic signatures in the areas of metagenomics, phylogenetics and the detection of horizontal gene transfer.
  • "Preface Computational biofluiddynamics addresses a diverse family of problems involving fluid flow inside and around living organisms, organs and tissue, biological cells, and other biological materials. Numerical methods combine aspects of computational mechanics, fluid dynamics, computational physics, computational chemistry and biophysics into an integrated framework that couples a broad range of scales. The goal of this edited volume is to provide a comprehensive, rigorous, and current introduction into the fundamental concepts, mathematical formulation, alternative approaches, and predictions of computational hydrodynamics of capsules and biological cells. The book is meant to serve both as a research reference and as a teaching resource. Scope The numerical methods discussed in the following eight chapters cover a broad range of possible formulations for simulating the motion of rigid particles (platelets) and the flow-induced deformation of liquid capsules and cells enclosed by viscoelastic membranes. Although some of the physical problems discussed in different chapters are similar or identical, the repetition is desirable in that solutions produced by different numerical approaches can be compared and the efficiency of alternative formulations can be assessed. The consistency of the results validates the procedures and offers several alternatives"--Provided by publisher.
  • Bioinformatic Tools for the Search of Disease-Associated Variations / Stefan Coassin, Anita Kloss-Brandstätter and Florian Kronenberg -- Cloud Computing / Bringing Computational Power to Medical Genetics / Lukas Forer, Sebastian Schönherr, Hansi Wei€ensteiner, Günther Specht and Florian Kronenberg, et al. -- High-Throughput Characterization and Comparison of Microbial Communities / Bettina Halwachs, Gregor Gorkiewicz and Gerhard G. Thallinger -- Microarray Meta-Analysis: From Data to Expression to Biological Relationships / Julia Feichtinger, Gerhard G. Thallinger, Ramsay J. McFarlane and Lee D. Larcombe -- Analysis of Labeled Quantitative Mass Spectrometry Proteomics Data / Florian Paul Breitwieser and Jacques Colinge -- Lipidomics, Mass Spectrometry, and Bioinformatics / Jürgen Hartler, Harald C. Köfeler, Christopher J. O. Baker, Ravi Tharakan and Gerhard G. Thallinger -- Protein Sequence-Structure-Function-Network Links Discovered with the ANNOTATOR Software Suite: Application to ELYS/Mel-28 / Georg Schneider, Westley Sherman, Durga Kuchibhatla, Hong Sain Ooi and Fernanda L. Sirota, et al. -- 3D Structure and Drug Design / Kristina Djinović-Carugo and Oliviero Carugo -- Integrating Biomolecular and Clinical Data for Cancer Research: Concepts and Challenges / Pornpimol Charoentong, Hubert Hackl, Bernhard Mlecnik, Gabriela Bindea and Jerome Galon, et al. -- Applied Data Mining: From Biomarker Discovery to Decision Support Systems / M. Osl, M. Netzer, S. Dreiseitl and C. Baumgartner -- Network-Based Methods for Computational Diagnostics by Means of R / Laurin A. J. Mueller, Matthias Dehmer and Frank Emmert-Streib.
  • This new volume of Methods in Enzymology continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers computational prediction RNA structure and dynamics, including such topics as computational modeling of RNA secondary and tertiary structures, riboswitch dynamics, and ion-RNA, ligand-RNA and DNA-RNA interactions.Continues the legacy of this premier serial with quality chapters authored by leaders in the field Covers computational methods and applications in RNA structure and dynamics.
  • Principles of model building : an experimentation-aided approach to development of models for signaling networks / Ambhighainath Ganesan and Andre Levchenko -- Integrated inference and analysis of regulatory networks from multi-level measurements / Christopher S. Poultney, Alex Greenfield, and Richard Bonneau -- Swimming upstream : identifying proteomic signals that drive transcriptional changes using the interactome and multiple "-omics" datasets / Shao-shan Carol Huang and Ernest Fraenkel -- A framework for modeling the relationship between cellular steady-state and stimulus-responsiveness / Paul M. Loriaux and Alexander Hoffmann -- Stochastic modeling of cellular networks / Jacob Stewart-Ornstein and Hana El-Samad -- Quantifying traction stresses in adherent cells / Casey M. Kraning-Rush ... [et al.] -- CellOrganizer : image-derived models of subcellular organization and protein distribution / Robert F. Murphy -- Spatial modeling of cell signaling networks / Ann E. Cowan ... [et al.] -- Stochastic models of cell protrusion arising from spatiotemporal signaling and adhesion dynamics / Erik S. Welf and Jason M. Haugh -- Nonparametric variable selection and modeling for spatial and temporal regulatory networks / Anil Aswani ... [et al.] -- Quantitative models of the mechanisms that control genome-wide patterns of animal transcription factor binding / Tommy Kaplan and Mark D. Biggin -- Computational analysis of live cell images of the Arabidopsis thaliana plant / Alexandre Cunha ... [et al.] -- Multi-scale modeling of tissues using CompuCell3D / Maciej H. Swat ... [et al.] -- Multiscale model of fibrin accumulation on the blood clot surface and platelet dynamics / Zhiliang Xu ... [et al.].
  • This volume, 'Computational Models of the Auditory System', will have as its unifying theme a systems approach where the focus will be on studies whose intent is to contribute to the big picture of hearing.
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  • Pt. 1. Pharmacological-based models of addiction -- pt. 2. Neurocomputational models of addiction -- pt. 3. Economic-based models of addiction.
  • Empirical pharmacokinetics -- Numerical methods for PK parameter estimation -- Physiological aspects on pharmacokinetics -- Modelling the distribution process -- PK/PD modelling.
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  • Computational systems biology 2009
    Springer Protocols
    Part 1. Network components -- 1. Identification of cis-regulatory elements in gene co-expression networks using A-GLAM / Leonardo Mariño-Ramírez ... [et al.] -- 2. Structure-based Ab initio prediction of transcription factor-binding sites / L. Angela Liu and Joel S. Bader -- 3. Inferring protein-protein interactions from multiple protein domain combinations / Simon P. Kanaan ... [et al.] -- 4. Prediction of protein-protein interactions: a study of the co-evolution model / Itai Sharon, Jason V. Davis, and Golan Yona -- 5. Computational reconstruction of protein-protein interaction networks: algorithms and issues / Eric Franzosa, Bolan Linghu, and Yu Xia -- 6. Prediction and integration of regulatory and protein-protein interactions / Duangdao Wichadakul, Jason McDermott, and Ram Samudrala -- 7. Detecting hierarchical modularity in biological networks / Erzsebet Ravasz -- Part 2. Network inference -- 8. Methods to reconstruct and compare transcriptional regulatory networks / M. Madan Babu, Benjamin Lang, and L. Aravind -- 9. Learning global models of transcriptional regulatory networks from data / Aviv Madar and Richard Bonneau -- 10. Inferring molecular interactions pathways from eQTL data / Imran Rashid, Jason McDermott, and Ram Samudrala -- 11. Methods for the inference of biological pathways and networks / Roger E. Bumgarner and Ka Yee Yeung -- Part 3. Network dynamics -- 12. Exploring pathways from gene co-expression to network dynamics / Huai Li, Yu Sun, and Ming Zhan -- 13. Network dynamics / Herbert M. Sauro -- 14. Kinetic modeling of biological systems / Haluk Resat, Linda Petzold, and Michel F. Pettigrew -- 15. Guidance for data collection and computational modelling of regulatory networks / Adam Christopher Palmer, and Keith Edward Shearwin -- Part 4. Function and evolutionary systems biology -- 16. Maximum likelihood method for reconstruction of the evolution of eukaryotic gene structure / Liran Carmel, ... [et al.] -- 17. Enzyme function prediction with interpretable models / Umar Syed and Golan Yona -- 18. Using evolutionary information to find specificity-determining and co-evolving residues / Grigory Kolesov and Leonid A. Mirny -- 19. Connecting protein interaction data, mutations, and disease using bioinformatics / Jake Y. Chen, Eunseog Youn, and Sean D. Mooney -- 20. Effects of functional bias on supervised learning of a gene network model / Insuk Lee and Edward M. Marcotte -- Part 5. Computational infrastructure for systems biology -- 21. Comparing algorithms for clustering of expression data: how to assess gene clusters / Golan Yona, William Dirks, and Shafquat Rahman -- 22. Bioverse API and web application / Michal Guerquin ... [et al.] -- 23. Computational representation of biological systems / Zach Frazier ... [et al.] -- 24. Biological network inference and analysis using SEBINI and CABIN / Ronald Taylor and Mudita Singhal.
  • Introducing computational systems biology / Roland Eils, Andres Kriete -- Structural systems biology : modeling interactions and networks for systems studies / Robert B. Russell, Gordana Apic, Olga Kalinina, Leonardo Trabuco, Matthew J. Betts, Qianhao Lu -- Understanding principles of the dynamic biochemical networks of life through systems biology / Hans V. Westerhoff, Fei He, Ettore Murabito, Frederic Cremazy, Matteo Barberis -- Biological foundations of signal transduction, systems biology and aberrations in disease / Ursula Klingmuller, Marcel Schilling, Sofia Depner, Lorenza A. D'Alessandro -- Complexities in quantitative systems analysis of signaling networks / Christina Kiel, Luis Serrano -- Gene networks : estimation, modeling, and simulation / Seiya Imoto, Hiroshi Matsuno, Satoru Miyano -- Reconstruction of metabolic network from genome information and its structural and functional analysis / Hong-Wu Ma, An-Ping Zeng -- Standards, platforms, and applications / Stanley Gu, Herbert Sauro -- Databases, standards, and modeling platforms for systems biology / Juergen Eils, Elena Herzog, Baerbel Felder, Christian Lawerenz, Roland Eils -- Computational models for circadian rhythms : deterministic versus stochastic approaches / Jean-christophe Leloup, Didier Gonze, Albert Goldbeter -- Top-down dynamical modeling of molecular regulatory networks / Reinhard Laubenbacher, Pedro Mendes -- Discrete gene network models for understanding multicellularity and cell reprogramming : from network structure to attractor landscapes landscape / Joseph Xu Zhou, Xiaojie Qiu, Aymeric Fouquier D'Herouel, Sui Huang -- Stochastic simulations of cellular processes : from single cells to colonies / John Cole, Mike J. Hallock, Piyush Labhsetwar, Joseph R. Peterson, John E. Stone, Zaida Luthey-Schulten -- Advances in machine learning for processing and comparison of metagenomic data / Jean-Luc Bouchot, William L. Trimble, Gregory Ditzler, Yemin Lan, Steve Essinger, Gail Rosen -- Systems biology of infectious diseases and vaccines / Helder I. Nakaya -- From cell behavior to tissue deformation : computational modeling and simulation of early animal embryogenesis with the mecagen platform / Julien Delile, Ren Doursat, Nadine Peyriras -- Developing a systems biology of aging / Andres Kriete, Mathieu Cloutier -- Morphometric analysis of tissue heterogeneity in glioblastoma multiforme -- Applications in cancer research : mathematical models of apoptosis / Stefan M. Kallenberger, Stefan Legewie, Roland Eils.
  • Functional Genomics and Molecular Networks Gene Expression Regulations in Complex Diseases: Down Syndrome as a Case Study / Marie-Claude Potier and Isabelle Rivals -- Reconstructing Models from Proteomics Data / Lysimachos Zografos, Andrew J. Pocklington and J. Douglas Armstrong -- Using Chemical Kinetics to Model Neuronal Signalling Pathways / Lukas Endler, Melanie I. Stefan, Stuart J. Edelstein and Nicolas Le Novère -- Breakdown of Mass-Action Laws in Biochemical Computation / Fidel Santamaria, Gabriela Antunes and Erik De Schutter -- Spatial Organization and Diffusion in Neuronal Signaling / Sherry-Ann Brown, Raquell M. Holmes and Leslie M. Loew -- The Performance (and Limits) of Simple Neuron Models: Generalizations of the Leaky Integrate-and-Fire Model / Richard Naud and Wulfram Gerstner -- Multi-compartmental Models of Neurons / Upinder S. Bhalla -- Noise in Neurons and Other Constraints / A. Aldo Faisal -- Methodological Issues in Modelling at Multiple Levels of Description / Kevin Gurney and Mark Humphries -- Virtues, Pitfalls, and Methodology of Neuronal Network Modeling and Simulations on Supercomputers / Anders Lansner and Markus Diesmann -- Co-operative Populations of Neurons: Mean Field Models of Mesoscopic Brain Activity / David T. J. Liley, Brett L. Foster and Ingo Bojak -- Cellular Spacing: Analysis and Modelling of Retinal Mosaics / Stephen J. Eglen -- Measuring and Modeling Morphology: How Dendrites Take Shape / Todd A. Gillette and Giorgio A. Ascoli -- Axonal Growth and Targeting / Duncan Mortimer, Hugh D. Simpson and Geoffrey J. Goodhill -- Encoding Neuronal Models in SBML / Sarah M. Keating and Nicolas Le Novère -- NeuroML / Padraig Gleeson, Volker Steuber, R. Angus Silver and Sharon Crook -- XPPAUT / Bard Ermentrout -- NEST by Example: An Introduction to the Neural Simulation Tool NEST / Marc-Oliver Gewaltig, Abigail Morrison and Hans Ekkehard Plesser.
  • Computational Toxicology: Methods and Applications for Risk Assessment is an essential reference on the translation of computational toxicology data into information that can be used for more informed risk assessment decision-making. This book is authored by leading international investigators who have real-world experience in relating computational toxicology methods to risk assessment. Key topics of interest include QSAR modeling, chemical mixtures, applications to metabolomic and metabonomic data sets, toxicogenomic analyses, applications to REACH informational strategies and much more. With a free companion website featuring an image bank from the book and web links for further research and reading, this authoritative reference is your complete guide to computational toxicology methods and applications to risk assessment. Authored by leading international researchers engaged in cutting-edge applications of computational methods for translating complex toxicological data sets into useful risk assessment information. Incorporates real-world examples of how computational toxicological methods have been applied to advance the science of risk assessment Provides the framework necessary for new technologies and fosters common vocabularies and principles upon which the effects of new chemical entities should be compared.
  • Basic principles of computed tomography physics and technical considerations / Kyongtae T. Bae and Bruce R. Whiting -- Magnetic resonance imaging principles and applications / Mark A. Brown and Richard C. Semelka -- Interventional computed tomography / Charles T. Burke, Matthew A. Mauro, and Paul L. Molina -- Neck / Franz J. Wippold II -- Thorax: techniques and normal anatomy / Fernando R. Gutierrez, Santiago Rossi, and Sanjeev Bhalla -- Mediastinum / Alvaro Huete-Garin and Stuart S. Sagel -- Lung / Stuart S. Sagel -- Pleura, chest wall, and diaphragm / David S. Gierada and Richard M. Slone -- Heart and pericardium / Pamela K. Woodard ... [et al.] -- Normal abdominal and pelvic anatomy / Dennis M. Balfe, Brett Gratz, and Christine Peterson -- Gastrointestinal tract / Cheri L. Canon -- Liver / Jay P. Heiken, Christine O. Menias, and Khaled Elsayes -- The biliary tract / Franklin N. Tessler and Mark E. Lockhart -- Spleen / David M. Warshauer -- The pancreas / Desiree E. Morgan and Robert J. Stanley -- Abdominal wall and peritoneal cavity / Jay P. Heiken, Christine O. Menias, and Khaled Elsayes -- Retroperitoneum / David M. Warshauer, Joseph K. T. Lee, and Harish Patel -- The kidney and ureter / Mark E. Lockhart, J. Kevin Smith, and Philip J. Kenney -- The adrenal glands / Suzan M Goldman and Philip J. Kenney -- Pelvis / Julia R. Fielding -- Computed tomography of thoracoabdominal trauma / Paul L. Molina ... [et al.] -- Musculoskeletal system / Robert Lopez-Ben, Daniel S. Moore, and D. Dean Thornton -- The spine / Zoran Rumboldt, Mauricio Castillo, and J. Keith Smith -- Pediatric applications / Marilyn J. Siegel.
  • Heart -- Aorta, arch vessels, and great veins -- Pulmonary arterial disease -- Mediastinum -- Airways -- Focal lung disease -- Lung cancer -- Diffuse lung disease -- Pleura, chest wall, and diaphragm.
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  • Computer-assisted surgery is a growing sub-discipline of orthopaedic surgery. This book offers a comprehensive presentation of scientific work and clinical experience including new technologies like individual templating in unicompartmental and total knee arthoplasty based on computer-assisted design technology. Computer-assisted surgery involves not only total knee and total hip arthroplasty, but also trauma, sports and revision surgery. In this edition we have added sections on 3D fluoroscopy-based spinal surgery as well as 3D fluoroscopy-based trauma surgery. Even in total hip surgery, navigation systems offer exciting new aspects, and the clinical benefit of navigation in total knee arthroplasties has now been demonstrated. We believe that this textbook will be of interest to those new to this specific field, while also providing an update for experienced users. An added benefit is the international character of this textbook, including experiences from Switzerland, Israel, the United States and the German-speaking countries.
  • Computer methods. Part A-C pt. A-B, C, 2009, 2011.
    pt. B, 2009 ScienceDirect
    pt. C, 2011 ScienceDirect
  • The major progress in computer vision allows us to make extensive use of medical imaging data to provide us better diagnosis, treatment and predication of diseases. Computer vision can exploit texture, shape, contour and prior knowledge along with contextual information from image sequence and provide 3D and 4D information that helps with better human understanding. Many powerful tools have been available through image segmentation, machine learning, pattern classification, tracking, reconstruction to bring much needed quantitative information not easily available by trained human specialists. The aim of the book is for both medical imaging professionals to acquire and interpret the data, and computer vision professionals to provide enhanced medical information by using computer vision techniques. The final objective is to benefit the patients without adding to the already high medical costs.
  • Architectural distortion is an important and early sign of breast cancer, but because of its subtlety, it is a common cause of false-negative findings on screening mammograms. Screening mammograms obtained prior to the detection of cancer could contain subtle signs of early stages of breast cancer, in particular, architectural distortion. This book presents image processing and pattern recognition techniques to detect architectural distortion in prior mammograms of interval-cancer cases. The methods are based upon Gabor filters, phase portrait analysis, procedures for the analysis of the angular spread of power, fractal analysis, Laws' texture energy measures derived from geometrically transformed regions of interest (ROIs), and Haralick's texture features. With Gabor filters and phase-portrait analysis, 4,224 ROIs were automatically obtained from 106 prior mammograms of 56 interval-cancer cases, including 301 true-positive ROIs related to architectural distortion, and from 52 mammograms of 13 normal cases. For each ROI, the fractal dimension, the entropy of the angular spread of power, 10 Laws' texture energy measures, and Haralick's 14 texture features were computed. The areas under the receiver operating characteristic (ROC) curves obtained using the features selected by stepwise logistic regression and the leave-one-image-out method are 0.77 with the Bayesian classifier, 0.76 with Fisher linear discriminant analysis, and 0.79 with a neural network classifier. Free-response ROC analysis indicated sensitivities of 0.80 and 0.90 at 5.7 and 8.8 false positives (FPs) per image, respectively, with the Bayesian classifier and the leave-one-image-out method. The present study has demonstrated the ability to detect early signs of breast cancer 15 months ahead of the time of clinical diagnosis, on the average, for interval-cancer cases, with a sensitivity of 0.8 at 5.7 FP/image. The presented computer-aided detection techniques, dedicated to accurate detection and localization of architectural distortion, could lead to efficient detection of early and subtle signs of breast cancer at pre-mass-formation stages.
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    Scheduling and preparing for the exam -- Conquering the CCS -- Managing time -- CCS versus reality -- Scoring -- Sample cases.
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