Lane Medical Library

Books

B

  • Digital
    Jennifer Tryggvi Blundo.
    This dissertation investigated the role of biomechanics in two physiological systems, the heart and bone. Biomechanics motivates the study and characterization of how cells sense external forces and convert these signals into an intracellular response in a process called mechanotransduction. Three independent studies were designed with the goal of applying mechanical forces that mimic the in vivo microenvironment of either the heart or bone. The aim of these studies was to better under the mechanisms driving cellular processes, including cardiac myocyte differentiation and osteoblast mechanotransduction. The first study presents the design and implementation of tissue engineering approach to stem cell-based myocardial therapy. Three dimensional engineered heart tissue was formed by suspending human embryonic stem cell-derived cardiac myocytes isolated from beating embryoid bodies in a soluble extracellular matrix, and an in vitro mechanical conditioning regimen was applied at physiological levels of myocardial strain. The viability of the engineered stem cell tissue was monitored in vitro and in vivo for up to 8 weeks using molecular imaging of reporter gene activity. The application of cyclic mechanical strain in vitro resulted in cellular alignment along the axis of strain and an elongated cellular morphology with a high nuclear to cytoplasmic ratio, typical of neonatal cardiac myocytes, as well as increased expression of cardiac troponin I, in comparison to static controls. Analysis of the in vitro and in vivo bioluminescence imaging data demonstrated the viability of engineered heart tissue constructs; however, histology results showed immature cells within the implanted constructs, suggesting an inability of the stem cell-derived cardiac precursors to maintain a cardiac phenotype in vivo, as well the inherent inefficiency of the beating embryoid body method to identify and isolate cardiac myocyte precursors. The functional shortcomings exhibited by the embryoid body-based differentiation of embryonic stem cell-derived cardiac myocytes in the first study motivated further refinement of cardiac myocyte differentiation techniques. Therefore, the second study executed the design and fabrication of a microelectromechanical platform to study the role of electrical and mechanical stimulation in cardiac myocyte differentiation. The fabrication process used a combination of soft lithography and traditional microfabrication techniques to pattern thin film metal electrodes on an elastomeric polymer membrane. The completed device enabled coupled characterization and imaging of cardiac myocytes precursors, and the ability to assess the range of mechanical forces, up to 10% equibiaxial strain, that may induce or maintain a cardiac fate. Electrical continuity was demonstrated under static conditions but not under strain, and improvements in metal deposition and adhesion could address this performance defect. Beating clusters containing human embryonic stem cell-derived cardiac myocytes were plated on fabricated membranes, uncoated and coated with Matrigel, and cell viability was monitored using contrast microscopy. The third study transitioned to a different mechanical model of physiological forces, which was the application of oscillatory fluid flow-mediated fluid shear stress generated by the loading and unloading of bone. Specifically, the role of focal adhesion kinase, a protein tyrosine kinase recruited at focal adhesions and a major mediator of integrin signaling pathways, was studied in osteoblast mechanotransduction. The biochemical and transcriptional response of focal adhesion kinase mutant osteoblasts to physiological levels of shear stress induced by oscillatory fluid flow was impaired as measured by prostaglandin E2 release and cyclooxygenase-2 gene expression. Restoration of focal adhesion kinase expression with site-specific mutations at two tyrosine phosphorylation sites demonstrated that phosphorylation events play a role in prostaglandin release following oscillatory fluid flow. In conclusion, the role of mechanical forces, including the effect of cyclic mechanical strain in human embryonic stem cell-derived cardiac myocyte tissue engineering and the fluid shear stress-induced response of focal adhesion kinase mutant osteoblasts, was successfully demonstrated and quantified in this dissertation.
  • Digital
    Kemal Levi.
    The outermost layer of human skin, the stratum corneum (SC), is subject daily to variable ambient moisture and temperature conditions as well as application of potentially damaging cleansing agents. The inevitable results of these exposures are "tightness" of the skin which is directly related to the buildup of tensile residual drying stresses in the SC layer. In this work, we first describe the application of the substrate curvature technique to quantitatively measure the magnitude of these stresses and their relationship to selected drying environments and times. The SC drying stresses were observed to be very sensitive to the relative humidity and temperature of the drying environment as well as harshness of the chemical treatment. There was a strong correlation with the SC drying stresses and the chemical potential of water in the drying environment. The evolution of drying stresses in SC is discussed in relation to the effects of hydration and damage caused by chemical treatments on the underlying SC structure. We also describe the application of the substrate curvature technique to characterize stresses in occlusive topical coatings. We then extend the substrate curvature technique to measure the combined effects of the coating applied to human stratum corneum (SC) where the overall drying stresses may have contributions from the coating, the SC and the interaction of the coating with the SC. We show how these separate contributions in the coating and SC layers can be differentiated. Using this methodology, we characterize the effect of a range of moisturizing treatments on the drying stresses in human stratum corneum. Following moisturizer treatment, the SC was observed to have distinctive stress profiles with drying time depending on the effectiveness of the treatment. The stress values of specimens treated with the humectant moisturizers were observed to increase and stabilize after a few hours in the drying environment where they remained relatively constant until the end of exposure to the drying environment whereas the stress values of specimens treated with the emollient treatments were observed to rise rapidly to a peak stress value and relax to a final stress value. The effect of moisturizing treatments on the SC drying stresses was rationalized in terms of SC water loss and the chemical state of the SC components. Finally, we employ a fracture mechanics approach to understand the implications of the drying stresses in SC as a mechanical driving force for damage propagation (e.g. cracking and chapping) in the tissue. The crack driving force G was found for several cracking configurations and compared with the intercellular delamination energy, Gc, which is a property of the tissue that provides a measure of the resistance to cracking. Using this approach, we demonstrate how damaging treatments enhance and moisturizing treatments alleviate the propensity for dry skin damage.
  • Digital
    Mark R. Pitkin.
    Springer2010
  • Digital
    Edward C. Benzel.
    Thieme MedOne Neurosurgery2014
  • Digital
    R.N. Miftahof, H.G. Nam.
    Springer2013
  • Digital
    by Tien Tuan Dao, Marie-Christine Ho Ba Tho.
    Wiley2014
    Chapter 1. Biomechanics of the musculoskeletal system -- Chapter 2. Modeling of biomedical data uncertainty -- Chapter 3. Knowledge modeling in biomechanics of the musculoskeletal system -- Chapter 4. Clinical applications of biomechanical and knowledge-based models -- Chapter 5. Software and tools for knowledge modeling and reasoning/interference.
  • Digital
    Lisa A. Eaton, Seth C. Kalichman, editors.
    Springer2014
    Three decades into the epidemic, a great deal is known about HIV and its transmission, more people are living with the disease, and the virus is no longer seen as a death sentence. But new people continue to be infected with HIV each year, making prevention strategies that are medically effective and behaviorally engaging as urgent a priority as ever. Biomedical Advances in HIV Prevention: Social and Behavioral Perspectives assembles the latest improvements, barriers to implementation, and possibilities for--and challenges to--future progress. Innovations such as pre-exposure prophylaxis (antiretroviral regimens for the high-risk uninfected) and treatment as prevention (early use of ART to reduce infectiousness of new patients) are examined, as are current findings on ongoing prevention and treatment concerns. Contributors illuminate the complex realities entailing adherence, pointing out technological, behavioral, and cultural roadblocks as well as opportunities to significantly reduce infection rates.
  • Digital
    Thomas Jue, editor.
    Springer2010
    Protein Structure Prediction / Patrice Koehl -- Molecular Modeling of Biomembranes: A How-to Approach / Allison N. Dickey and Roland Faller -- Introduction to Electron Paramagnetic Resonance Spectroscopy / Marcin Brynda -- Theory and Applications of Biomolecular NMR Spectroscopy / James B. Ames -- FRET and Its Biological Application as a Molecular Ruler / Jie Zheng -- Introduction to Modern Techniques in Mass Spectrometry / Caroline S. Chu and Carlito B. Lebrilla -- Transmission Electron Microscopy and Computer-Aided Image Processing for 3D Structural Analysis of Macromolecules / Dominik J. Green and R. Holland Cheng -- Raman Spectroscopy of Living Cells / Tyler Weeks and Thomas Huser.
  • Digital
    Jaroslav Šebestík, Milan Reiniš, Jan Ježek.
    Springer2012
    Introduction -- Chemistry and structure of dendrimers. Definition of terms and nomenclature ; Sugar code (glyc code) ; Classes of peptide-, glyco, and glycopeptide dendrimers ; The dendritic state and dendritic effects ; Synthesis of dendrimers : convergent and divergent approaches ; Purification and characterization of dendrimers ; Dendrimeric libraries ; Dendrimers in catalysis -- Dendrimers and their biological and therapeutic applications. Dendrimers and solubility ; Biocompability and toxicity of dendrimers ; Dendrimers in nanoscience and nanotechnology ; Dendrimers in drug delivery ; Dendrimers in gene delivery ; Dendrimers and bacteria ; Dendrimers and viruses ; Dendrimers and parasites ; Cancer ; Diagnostics, lectin detection and cell-cell interactions ; Dendrimers as biosensors and imaging tools ; Dendrimers regulating in intracellular signaling pathways ; Vaccines and immunomodulation ; Dendrimers in neurodegenerative diseases ; Conclusions and perspectives. .
  • Digital
    Mohammed Shahid ... [et al.], editors.
    Springer2010
  • Digital
    Edward Klees and H. Robert Horvitz.
    ProQuest Ebook Central2012
    Issues to consider when negotiating a consulting agreement -- What constitutes consulting? -- Scope of services -- Cash compensation -- Shares, stock options, and taxes -- Confidentiality obligations -- IP rights -- Noncompetition -- Time commitment -- Term and termination -- Multiple relationships with one company -- Start-up issues -- Other clauses -- Use of consulting entity.
  • Digital
    edited by Sandra R. [i.e. S.] Eaton, Gareth R. Eaton, and Lawrence J. Berliner.
    Springerpt. A, 2004
    Springerpt. B, 2004
    Pt. A. Free radicals, metals, medicine, and physiology -- Pt. B. Methodology, instrumentation, and dynamics.
  • Digital
    Aly A. Farag.
    Cambridge2014
    Overview of biomedical image analysis -- Overview of two-dimensional signals and systems -- Biomedical imaging modalities -- Random variables -- Random processes -- Basics of random fields -- Probability density estimation by linear models -- Basics of topology and computational geometry -- Geometric features extraction -- Variational approaches and level sets -- Segmentation -- statistical approach -- Segmentation -- variational approach -- Basics of registration -- Variational methods for shape registrations -- Statistical models of shape and appearance.
  • Digital
    Carlos Reyes-Aldasoro.
    Wiley2015
    As its title suggests, this innovative book has been written for life scientists needing to analyse their data sets, and programmers, wanting a better understanding of the types of experimental images life scientists investigate on a regular basis. Each chapter presents one self-contained biomedical experiment to be analysed. Part I of the book presents its two basic ingredients: essential concepts of image analysis and Matlab. In Part II, algorithms and techniques are shown as series of 'recipes' or solved examples that show how specific techniques are applied to a biomedical experiments like Western Blots, Histology, Scratch Wound Assays and Fluoresence. Each recipe begins with simple techniques that gradually advance in complexity. Part III presents some advanced techniques for the generation of publication quality figures. The book does not assume any computational or mathematical expertise.
  • Digital
    [edited by] Joo Hwee Lim, Sim Heng Ong, Wei Xiong.
    Wiley2015
    Overview of biomedical image understanding methods / Wei Xiong, Jierong Cheng, Ying Gu, Shimiao Li and Joo Hwee Lim -- Medical image segmentation and its application in cardiac MRI / Dong Wei, Chao Li and Ying Sun -- Retinal vascular measurements with VAMPIRE / Emanuele Trucco, Andrea Giachetti, Lucia Ballerini, Devanjali Relan, Alessandro Cavinato and Tom MacGillivray -- Analyzing cell and tissue morphologies using pattern recognition algorithms / Hwee Kuan Lee, Yan Nei Law, ChaoHui Huang and Choon Kong Yap -- 3D nonrigid image registration by Parzenwindow based normalized mutual information / Rui Xu, YenWei Chen, Shigehiro Morikawa and Yoshimasa Kurumi -- 2D/3D image registration for endovascular abdominal aortic aneurysm (AAA) repair / Shun Miao and Rui Liao -- Motion tracking in medical images / Chuqing Cao, Chao Li and Ying Sun -- Blood smear analysis and malaria infection detection from blood cell images / Wei Xiong, SimHeng Ong, Joo Hwee Lim, Jierong Cheng and Ying Gu -- Liver tumor segmentation using SVM framework and pathology characterization / Jiayin Zhou, Yanling Chi, Weimin Huang, Wei Xiong, Wenyu Chen, Jimin Liu and Sudhakar K. Venkatesh -- Benchmarking lymph node metastasis classification for gastric cancer staging / Su Zhang, Chao Li, Shuheng Zhang, Lifang Pang and Huan Zhang -- The use of knowledge in biomedical image analysis / Florence Cloppet -- Active shape model for contour detection of anatomical structure / Huiqi Li and Qing Nie.
  • Digital
    edited by Reiner Salzer.
    Wiley2012
    Evaluation of spectroscopic images -- Evaluation of tomographic data -- X-ray imaging -- Computed tomography -- Magnetic resonance tomography -- Toward a 3D view of cellular architecture: correlative light microscopy and electron tomography -- Tracer imaging -- Fluorescent imaging -- Infrared and Raman spectroscopic imaging -- Coherent anti-strokes Raman scattering microscopy -- Biomedical sonography -- Acoustic microscopy for biomedical applications.
  • Digital/Print
    Edward H. Shortliffe, editor; James J. Cimino, associate editor.
    Digital : Springer2006
    Print2006
  • Digital
    Cimino, James J.; Shortliffe, Edward H.
    Springer2014
    Biomedical Informatics: Computer Applications in Health Care and Biomedicine meets the growing demand of practitioners, researchers, educators, and students for a comprehensive introduction to key topics in the field and the underlying scientific issues that sit at the intersection of biomedical science, patient care, public health, and information technology (IT). This 4th edition reflects the remarkable changes in both computing and health care that continue to occur and the exploding interest in the role that IT must play in care coordination and the melding of genomics with innovations in clinical practice and treatment. New chapters have been introduced on the health information infrastructure, consumer health informatics, telemedicine, translational bioinformatics, clinical research informatics, and health IT policy, while the others have all undergone extensive revisions, in many cases with new authors. The organization and philosophy are unchanged, focusing on the science of information and knowledge management and the role of computers and communications in modern biomedical research, health, and health care. Emphasizing the conceptual basis of the field rather than technical details, it provides an introduction and extensive bibliography so that readers can comprehend, assess, and utilize biomedical informatics and health IT. The volume focuses on easy-to-understand examples, a guide to additional literature, chapter summaries, and a comprehensive glossary with concise definitions of recurring terms for self-study or classroom use.
  • Digital
    Michael F. Ochs, John T. Casagrande, Ramana V. Davuluri, editors.
    Springer2010
  • Digital
    edited by Ashutosh Tiwari, Murugan Ramalingam, Hisatoshi Kobayashi, Anthony P.F. Turner.
    Wiley2012
    Application of the collagen as biomaterials / Kwangwoo Nam and Akio Kishida -- Biological and medical significance of nanodimensional and nanocrystalline calcium orthophosphates / Sergey V. Dorozhkin -- Layer-by-layer (LbL) thin film : from conventional to advanced biomedical and bioanalytical applications / Wing Cheung -- Polycaprolactone based nanobiomaterials / Narendra K. Singh and Pralay Maiti -- Bone substitute materials in trauma and orthopedic surgery properties and use in clinic / Esther M.M. Van Lieshout -- Surface functionalized hydrogel nanoparticles / Mehrdad Hamidi, Hajar Ashrafi, and Amir Azadi -- Utility and potential application of nanomaterials in medicine / Ravindra P. Singh [and others] -- Gold nanoparticle-based electrochemical biosensors for medical applications / Ulku Anik -- Impedimetric DNA sensing employing nanomaterials / Manel del Valle and Alessandra Bonanni -- Bionanocomposite matrices in electrochemical biosensors / Ashutosh Tiwari, Atul Tiwari -- Biosilica-nonocomposites-nanobiomaterials for biomedical engineering and sensing applications / Nikos Chaniotakis, Raluca Buiculescu -- Molecularly imprinted nanomaterial-based highly sensitive and selective medical devices / Bhim Bali Prasad and Mahavir Prasad Tiwari -- Immunosensors for diagnosis of cardiac injury / Swapneel R. Deshpande [and others] -- Ground-breaking changes in mimetic and novel nanostructured composites for intelligent-, adaptive-, and in vivo-responsive drug delivery therapies / Dipak K. Sarker -- Progress of nanobiomaterials for theranostic systems / Dipendra Gyawali [and others] -- Intelligent drug delivery systems for cancer therapy / Mousa Jafari [and others] -- The evolution of abdominal wall reconstruction and the role of nonobiotecnology in the development of intelligent abdominal wall mesh / Cherif Boutros, Hany F. Sobhi, and Nader Hanna -- Poly(polyol sebacate)-based elastomeric nanobiomaterials for soft tissue engineering / Qizhi Chen -- Electrospun nanomatrix for tissue regeneration / Debasish Mondal and Ashutosh Tiwari -- Conducting polymer composites for tissue engineering scaffolds / Yashpal Sharma, Ashutosh Tiwari, and Hisatoshi Kobayashi -- Cell patterning technologies for tissue engineering / Azadeh Seidi and Murugan Ramalingam.
  • Digital
    edited by Sarah J. Hurst.
    Springer Protocols2011
    Biomedical nanotechnology / Sarah J. Hurst -- Multiplexed detection of oligonucleotides with biobarcoded gold nanoparticle probes / Jae-Seung Lee -- Molecular detection of biomarkers and cells using magnetic nanoparticles and diagnostic magnetic resonance / Jered B. Haun ... [et al.] -- Real-time quantum dot tracking of single proteins / Jerry C. Chang and Sandra J. Rosenthal -- Titanium dioxide nanoparticles in advanced imaging and nanotherapeutics / Tijana Rajh, Nada M. Dimitrijevic, and Elena A. Rozhkova -- Surface modification and biomolecule immobilization on polymer spheres or biosensing applications / Chris R. Taitt ... [et al.] -- Multivalent conjugation of peptides, proteins, and DNA to semiconductor quantum dots / Duane E. Prasuhn, Kimihiro Susumu, and Igor L. Medintz -- Single snO2 nanowire-based microelectrode / Jun Zhou ... [et al.] -- Biosensing using nanoelectromechanical systems / Ashish Yeri and Di Gao -- Nano "Fly Paper" technology for the capture of circulating tumor cells / Shutao Wang, Gwen E. Owens, and Hsian-Rong Tseng -- Polymeric nanoparticles for photodynamic therapy / Young-Eun Koo Lee and Raoul Kopelman -- Hydrogel templates for the fabrication of homogeneous polymer microparticles / Ghanashyam Acharya ... [et al.] -- Antibacterial application of engineered bacteriophage nanomedicines : antibody-targeted, chloramphenicol prodrug loaded bacteriophages for inhibiting the growth of staphylococcus aureus bacteria / Lilach Vaks and Itai Benhar -- Viruses as nanomaterials for drug delivery / Dustin Lockney, Stefan Franzen, and Steven Lommel -- Applications of carbon nanotubes in biomedical studies / Hongwei Liao ... [et al.] -- Electrospun nanofibrous scaffolds for engineering soft connective tissues / Roshan James ... [et al.] -- Peptide amphiphiles and porous biodegradable scaffolds for tissue regeneration in the brain and spinal cord / Rutledge G. Ellis-Behnke and Gerald E. Schneider -- Computational simulations of the interaction of lipid membranes with DNA-functionalized gold nanoparticles / One-Sun Lee and George C. Schatz -- Cytotoxic assessment of carbon nanotube interaction with cell cultures / Hanene Ali-Boucetta, Khuloud T. Al-Jamal, and Kostas Kostarelos -- Nanoparticle toxicology : measurements of pulmonary hazard effects following exposures to nanoparticles / Christie M. Sayes, Kenneth L. Reed, and David B. Warheit -- Nanoparticle therapeutics : FDA approval, clinical trials, regulatory pathways, and case study / Aaron C. Eifler and C. Shad Thaxton -- Legislating the laboratory? Promotion and precaution in a nanomaterials company / Robin Phelps and Erik Fisher -- Navigating the patent landscapes for nanotechnology : english gardens or tangled grounds / Douglas J. Sylvester and Diana M. Bowman -- Scientific entrepreneurship in the materials and life science industries / Jose Amado Dinglasan, Darren J. Anderson, and Keith Thomas -- Applying the marketing mix (5 Ps) to bionanotechnology / Michael S. Tomczyk -- Managing the "Known Unknowns" : theranostic cancer nanomedicine and informed consent / Fabrice Jotterand and Archie A. Alexander.
  • Digital
    Kevin Bretonnel Cohen, Dina Demner-Fushman.
    ProQuest Ebook Central2014
    Biomedical Natural Language Processing" is a comprehensive tour through the classic and current work in the field. It discusses all subjects from both a rule-based and a machine learning approach, and also describes each subject from the perspective of both biological science and clinical medicine. The intended audience is readers who already have a background in natural language processing, but a clear introduction makes it accessible to readers from the fields of bioinformatics and computational biology, as well. The book is suitable as a reference, as well as a text for advanced courses in biomedical natural language processing and text mining.
  • Digital
    edited by Brian J.-F. Wong, Justus Ilgner.
    Springer2016
    Contemporary laser surgical procedures in the head and neck -- Advanced therapeutic concepts of light therapy -- Photodynamic therapy -- Optical diagnostics: introduction.
  • Digital
    Seward B. Rutkove.
    Springer2016
    Foreword -- PART 1: Basic considerations -- 1. So do you really want to pursue research? -- 2. What's in store: The brighter side of medical research -- 3. What's in store: The darker side of medical research -- 4. One degree of separation -- 5. Choosing and working with a mentor -- 6. Identifying a research niche you can call your own -- 7. Useful Definitions -- PART 2: Research Foundations and Structures -- 8. The Institutional Review Board: Do's, Don'ts, and Nevers... -- 9. Animal Care and Use Committees -- 10. Research beyond humans and vertebrates -- 11. Hiring Research Staff -- 12. Strategy and Tactics: Running a Successful Laboratory -- 13. Everything you ever wanted to know about collaboration Part 3: Successful Paper and Grant Writing -- 14. Writing a successful research paper. I -- Up to the point of submission -- 15. Writing a successful research paper. II -- Revising, resubmitting, and post-acceptance tasks -- 16. Funding: An overview -- 17. Where to apply for funding: making the right choices -- 18. Writing a winning grant application -- 19. Grant budgeting -- 20. Grant writing: Pearls and lumps of coal -- 21. Research Training, Fellowship, and Career grants -- 22. Grant review from the inside -- 23. Interpreting your reviews -- 24. To resubmit or not resubmit and how to do it -- Part 4: Good presentations, conferencing, networking, and other useful tools -- 25. The art of good presentation -- 26. Effective conferencing -- 27. Networking in the 21st century -- 28. Conflicts of interest -- 29. Scientific conduct and misconduct: what is right and proper, what is not, and what is somewhere in the middle -- 30. Article review and reading: being efficient and as thorough as you need to be -- 31. Patents -- 32. Working with industry -- Part 5: Career choices and life lessons -- 33. Jobs in biomedical science: seeking, landing, and changing -- 34. Academic Promotion and Titles -- 35. On being a mentor -- 36. Yardsticks of success -- 37. Research Life Lesson #1: Everything takes longer than you think, so plan for it -- 38. Research life lesson #2: A person's research is endlessly important to them -- 39. Research Life lesson #3: Balance, timing, cycles and seeing the big picture -- 40. Research Life Lesson #4: Your career is an ultramarathon, not a sprint -- 41. Conclusion: Nothing satisfies like meaningful work -- Acknowledgements.
  • Digital
    edited by Ray K. Iles, Suzanne M. Docherty, Stephen Butler.
    ProQuest Ebook Central2012
    Chapter 1. Anatomy and physiology of major organ systems -- Chapter 2. Pathophysiology -- Chapter 3. Clinical cell biology and genetics -- Chapter 4. Cellular pathology -- Chapter 5. Clinical chemistry -- Chapter 6. Medical microbiology -- Chapter 7. Clinical immunology -- Chapter 8 Haematology and transfusion science -- Chapter 9. Professional practice and biomedical science.
  • Digital
    Joseph V. Tranquillo.
    Atypon2014
    Biomedical Signals and Systems is meant to accompany a one-semester undergraduate signals and systems course. It may also serve as a quick-start for graduate students or faculty interested in how signals and systems techniques can be applied to living systems. The biological nature of the examples allows for systems thinking to be applied to electrical, mechanical, fluid, chemical, thermal and even optical systems. Each chapter focuses on a topic from classic signals and systems theory: System block diagrams, mathematical models, transforms, stability, feedback, system response, control, time and frequency analysis and filters. Embedded within each chapter are examples from the biological world, ranging from medical devices to cell and molecular biology. While the focus of the book is on the theory of analog signals and systems, many chapters also introduce the corresponding topics in the digital realm. Although some derivations appear, the focus is on the concepts and how to apply them. Throughout the text, systems vocabulary is introduced which will allow the reader to read more advanced literature and communicate with scientist and engineers. Homework and Matlab simulation exercises are presented at the end of each chapter and challenge readers to not only perform calculations and simulations but also to recognize the real-world signals and systems around them.
  • Digital
    Fernando Bello, P.J. "Eddie" Edwards (eds.).
    Springer2008
  • Digital
    Phillip Weinfurt.
    Atypon2010
    Evaluating biomedical technology poses a significant challenge in light of the complexity and rate of introduction in today's healthcare delivery system. Successful evaluation requires an integration of clinical medicine, science, finance, and market analysis. Little guidance, however, exists for those who must conduct comprehensive technology evaluations. The 3Q Method meets these present day needs. The 3Q Method is organized around 3 key questions dealing with 1) clinical and scientific basis, 2) financial fit and 3) strategic and expertise fit. Both healthcare providers (e.g., hospitals) and medical industry providers can use the Method to evaluate medical devices, information systems and work processes from their own perspectives. The book describes the 3Q Method in detail and provides additional suggestions for optimal presentation and report preparation.
  • Print
    edited by Adele E. Clarke, Laura Mamo, Jennifer Ruth Fosket, Jennifer R. Fishman, Janet K. Shim.
    Biomedicalization : technoscientific transformations of health, illness, and U.S biomedicine / Adele E. Clarke, Janet K. Shim, Laura Mamo, Jennifer Ruth Fosket, and Jennifer R. Fishman -- Charting (bio)medicine and (bio)medicalization in the United States, 1890/present / Adele E. Clarke, Jennifer Ruth Fosket, Laura Mamo, Jennifer R. Fishman, and Janet K. Shim -- From the rise of medicine to biomedicalization : U.S. healthscapes and iconography, circa 1890/present / Adele E. Clarke -- Gender and medicalization and biomedicalization theories / Elianne Riska -- Fertility, Inc. : consumption and subjectification in U.S. lesbian reproductive practices / Laura Mamo -- The body as image : an examination of the economic and political dynamics of magnetic resonance imaging and the construction of difference / Kelly Joyce -- The stratified biomedicalization of heart disease : expert and lay perspectives on racial and class inequality / Janet K. Shim -- Marking populations and persons at risk : molecular epidemiology and environmental health / Sara Shostak -- Surrogate markers and surrogate marketing in biomedicine : the regulatory etiology and commercial progression of "ethnic" drug development / Jonathan Kahn -- The making of Viagra : the biomedicalization of sexual dysfunction / Jennifer R. Fishman -- Bypassing blame : bariatric surgery and the case of biomedical failure / Natalie Boero -- Breast cancer risk as disease : biomedicalizing risk / Jennifer Ruth Fosket -- Biopsychiatry and the informatics of diagnosis : governing mentalities / Jackie Orr.
  • Digital/Print
    edited by Lester Packer.
    Digital : ScienceDirect1982
    Print1982
  • Digital/Print
    edited by Lester Packer.
    Digital : ScienceDirect1982
    Print1982
  • Digital/Print
    edited by Sidney Fleischer, Becca Fleischer.
    Digital : ScienceDirect1983
    Print1983
  • Digital/Print
    edited by Sidney Fleischer, Becca Fleischer.
    Digital : ScienceDirect1983
    Print1983
  • Digital/Print
    edited by Sidney Fleischer, Becca Fleischer.
    Digital : ScienceDirect1983
    Print1983
  • Digital/Print
    edited by Sidney Fleischer, Becca Fleischer.
    Digital : ScienceDirect1986
    Print1986
  • Digital/Print
    edited by Sidney Fleischer, Becca Fleischer.
    Digital : ScienceDirect1986
    Print1986
  • Digital/Print
    edited by Lester Packer.
    Digital : ScienceDirect1986
    Print1986
  • Digital/Print
    edited by Sidney Fleischer, Becca Fleischer.
    Digital : ScienceDirect1988
    Print1988
  • Digital/Print
    edited by Sidney Fleischer, Becca Fleischer.
    Digital : ScienceDirect1988
    Print1988
  • Digital/Print
    edited by Sidney Fleischer, Becca Fleischer.
    Digital : ScienceDirect1989
    Print1989
  • Digital/Print
    edited by Sidney Fleischer, Becca Fleischer.
    Digital : ScienceDirect1989
    Print1989
  • Digital/Print
    edited by Sidney Fleischer, Becca Fleischer.
    Digital : ScienceDirect1989
    Print1989
  • Digital/Print
    edited by Sidney Fleischer, Becca Fleischer.
    Digital : ScienceDirect1989
    Print1989
  • Digital/Print
    edited by Sidney Fleischer, Becca Fleischer.
    Digital : ScienceDirect1990
    Print1990
  • Digital/Print
    edited by Sidney Fleischer, Becca Fleischer.
    Digital : ScienceDirect1990
    Print1990
  • Digital
    edited by Anthony R. White, Michael Aschner, Lucio G. Costa, Ashley I. Bush.
    ScienceDirect2017
    Biometals and Alzheimer's disease / Alexandra I. Mot, Peter J. Crouch -- Copper in Alzheimer's disease / Rosanna Squitti, Maricarla Ventriglia, Mariacristina Siotto, Carlo Salustri -- The role of selenium in neurodegenerative diseases / Bárbara R. Cardoso, Dominic J. Hare, Ashley I. Bush -- Does HFE genotype impact macrophage phenotype in disease process and therapeutic response? / Anne M. Nixon, James R. Connor -- Chemical elements and oxidative status in neuroinflammation / Michela Ferraldeschi, Silvia Romano, Maria C. Buscarinu, Arianna Fornasiero, Rosella Mechelli, Benedetta Cerasoli, Anna Pino, Sonia Brescianini, Carlo Mattei, Maria A. Stazi, Alessandro Alimonti, Marco Salvetti, Giovanni Ristori -- Metals and neuroinflammation / Stephen C. Bondy -- Metals and prions / David R. Brown -- Manganese and neurodegeneration / Dinamene Marques Dos Santos, Michael Aschner, Ana P. Marrielha Dos Santos -- Zinc in autism / Stefanie Grabrucker, Andreas M. Grabrucker -- Metals and motor neuron disease / Per M. Roos -- Metals and Lysosomal storage disorders / Henna Kontinnen, Katarína Lejavová, Tarja Malm, Katja M Kanninen -- Developmental exposure to metals and its contribution to age-related neurodegeneration / Lucio G. Costa -- Metal biology associated with Huntington's disease / Terry Jo V. Bichell, Timothy C. Halbesma, K. Grace Tipps, Aaron B. Bowman -- Metal-binding to Amyloid-ss peptide / Melisa Del Barrio, Valentina Borghesani, Christelle Hureau, Peter Faller -- Metals and mitochondria in neurodegeneration / Germán Plascencia-Villa, Miguel José- Yacamán, George Perry -- Metal transporters in neurodegeneration / Hong Jiang -- Metal imaging in the brain / David C. Dorman -- Metalloregulation of protein clearance / Alejandra Ramírez Muñoz, Mark A. Greenough, Ashley I. Bush, Carlos M. Opazo -- Metals and autophagy in neurotoxicitiy / Peng Su, Michael Aschner, Jingyuan Chen, Wenjing Luo -- An overview of multifunctonal metal chelators as potential treatments for neurodegenerative diseases / Frank W. Lewis, David Tétard -- Abnormal function of metalloprotein underlies most neurodegenerative diseases / Katja M. Kanninen, Anthony R. White.
  • Digital
    edited by Matteo Santin, Gary Phillips.
    Wiley2012
    1. History of miomimetic, bioactive and bioresponse biomaterials -- 2. Soft tissue structure and functionality -- 3. Hard tissue structure and functionality -- 4. Biomedical applications of biomimetic polymers: the phosphorylcholine-containing polymers -- 5. Biomimetic, bioresponsive, and bioactive materials: integrating materials with tissue -- 6. Ceramics -- 7. Biofunctional biomaterials of the future.
  • Digital
    edited by João F. Mano.
    Wiley2012
    Examples of natural and nature-inspired materials. Biomaterials from marine-origin biopolymers / Tiago H Silva, Ana R C Duarte, Joana Moreira-Silva, João F Mano, Rui L Reis -- Hydrogels from protein engineering / Midori Greenwood-Goodwin, Sarah C Heilshorn -- Collagen-based biomaterials for regenerative medicine / Christophe Helary, Abhay Pandit -- Silk-based biomaterials / Silvia Gomes, Isabel B Leonor, João F Mano, Rui L Reis, David L Kaplan -- Elastin-like macromolecules / Rui R Costa, Laura Martin, João F Mano, Jose C Rodriguez-Cabello -- Biomimetic molecular recognition elements for chemical sensing / Justyn Jaworski -- Surface aspects. Biology lessons for engineering surfaces for controlling cell-material adhesion / Ted T Lee, Andres J Garcia -- Fibronectin fibrillogenesis at the cell-material interface / Marco Cantini, Patricia Rico, Manuel Salmeron-Sanchez -- Nanoscale control of cell behavior on biointerfaces / E Ada Cavalcanti-Adam, Dimitris Missirlis -- Surfaces with extreme wettability ranges for biomedical applications / Wenlong Song, Natalia M Alves, João F Mano -- Bio-inspired reversible adhesives for dry and wet conditions / Aranzazu del Campo, Juan Pedro Fernandez-Blazquez -- Lessons from sea organisms to produce new biomedical adhesives / Elise Hennebert, Pierre Becker, Patrick Flammang -- Hard and mineralized systems. Interfacial forces and interfaces in hard biomaterial mechanics / Devendra K Dubey, Vikas Tomar -- Nacre-inspired biomaterials / Gisela M Luz, João F Mano -- Surfaces inducing biomineralization / Natalia M Alves, Isabel B Leonor, Helena S Azevedo, Rui L Reis, João F Mano -- Bioactive nanocomposites containing silicate phases for bone replacement and regeneration / Melek Erol, Jasmin Hum, Aldo R Boccaccini -- Systems for the delivery of bioactive agents. Biomimetic nanostructured apatitic matrices for drug delivery / Norberto Roveri, Michele Iafisco -- Nanostructures and nanostructured networks for smart drug delivery / Carmen Alvarez-Lorenzo, Ana M Puga, Angel Concheiro -- Progress in dendrimer-based nanocarriers / Joaquim M Oliveira, João F Mano, Rui L Reis -- Lessons from nature in regenerative medicine. Tissue analogs by the assembly of engineered hydrogel blocks / Shilpa Sant, Daniela F Coutinho, Nasser Sadr, Rui L Reis, Ali Khademhosseini -- Injectable -forming scaffolds for tissue engineering / Da Yeon Kim, Jae Ho Kim, Byoung Hyun Min, Moon Suk Kim -- Biomimetic hydrogels for regenerative medicine / Iris Mironi-Harpaz, Olga Kossover, Eran Ivanir, Dror Seliktar -- Bio-inspired 3d environments for cartilage engineering / Jose Luis Gomez Ribelles -- Soft constructs for skin tissue engineering / Simone S Silva, João F Mano, Rui L Reis.
  • Digital
    edited by Murugan Ramalingam, Xiumei Wang, Guoping Chen, Peter Ma, and Fu-Zhai Cui.
    Wiley2013
    1. Biomimetic polysaccharides and derivatives for cartilage tissue regeneration -- 2. Biomimetic synthesis of self-assembled mineralized collagen-based composites for bone tissue engineering -- 3. Biomimetic mineralization of hydrogel biomaterials for bone tissue engineering -- 4. Biomimetic nanofibrous scaffolds for bone tissue engineering applications -- 5. Bioactive polymers and nanobiomaterials composites for bone tissue engineering -- 6. Strategy for a biomimetic paradigm in dental and craniofacial tissue engineering -- 7. Strategies to prevent bacterial adhesion on biomaterials -- 8. Nanostructured selenium- a novel biologically-inspired material for antibacterial medical device applications -- 9. Hydroxyapatite-biodegradable polymer nanocomposite microspheres toward injectable cell scaffold -- 10. Biomimetic ECM scaffolds prepared from cultured cells -- 11. Design and synthesis of phoreactive polymers for biomedical applications -- 12. The emerging applications of graphene oxide and graphene in tissue engineering -- 13. Biomimetic preparation and morphology control of mesoporous silica -- 14. Biomimetic materials for engineering stem cells and tissues.
  • Digital
    edited by Gordana Vunjak-Novakovic, Department of Biomedical Engineering and Department of Medicine, Columbia University, New York, NY, USA, Kursad Turksen, Sprott Centre for Stem Cell Research, Ottawa Hospital Research Institute, Ottawa, ON, Canada.
    Springer Protocols2014
    Derivation and network formation of vascular cells from human pluripotent stem cells -- High-throughput cell aggregate culture for stem cell chondrogenesis -- Microfluidic device to culture 3D in vitro human capillary networks -- Multifunction co-culture model for evaluating cell-cell interactions -- Multiwell plate tools for controlling cellular alignment with grooved topography -- Bioreactor cultivation of anatomically shaped human bone grafts -- Determining the role of matrix compliance in the differentiation of mammary stem cells -- Conjugation of proteins to polymer chains to create multivalent molecules -- An assay to quantify chemotactic properties of degradation products from extracellular matrix -- Biomimetic strategies incorporating enzymes into CaP coatings mimicking the in vivo environment -- Fabrication of biofunctionalized, cell-laden macroporous 3D PEG hydrogels as bone marrow analogs for the cultivation of human hematopoietic stem and progenitor cells -- Extracellular matrix mimetic peptide scaffolds for neural stem cell culture and differentiation -- The delivery and evaluation of RNAi therapeutics for heterotopic ossification pathologies -- Mimicking bone microenvironment for directing adipose tissue-derived mesenchymal stem cells into osteogenic differentiation -- Cultivation of human bone-like tissue from pluripotent stem cell-derived osteogenic progenitors in perfusion bioreactors.
  • Digital
    Wei Huang.
    Nature has been evolving unparalleled molecular designs with extraordinary activity, simplicity, efficiency, and durability. The process of biomimicry takes inspiration from Nature. In this dissertation, I focused on the development of functional analogues of natural peptides and protein polymers for several applications that continue to challenge the biomedical field. Five applications were discussed: The first three sections focus on bioactive peptides that are generally shorter than 50 amino acids. The goal was to preserve the bioactivity of the natural peptides while reducing their natural sensitivity to proteases and fast in vivo clearance. The last two sections focus on developing protein polymer-based hydrogels. The goal was to generate biomimicking scaffolds for tissue regenerations. (i) Poly-N-substituted glycines, or peptoids, provide a biostable scaffold that can display a great diversity of side chains in highly tunable sequences via facile solid-phase synthesis. Current chemotherapeutics in oncology are often limited by side effect profiles and selection for drug resistance. Herein, I present a library of anticancer peptoids that mimic the cationic, amphipathic structural features of host defense peptides and explore their structure-activity relationship, and killing mechanisms. Several peptoids were found with broad cytotoxicity against cancer cells as well as the ability to overcome multidrug resistance. An initial in vivo study with a primary, orthotopic human breast cancer xenotransplantation model demonstrated anticancer efficacy of one of the studied peptoids. (ii) Cell-penetrating peptides have found numerous applications in biology and medicine as molecular transporters. We developed a library of cationic, amphipathic peptoids as a novel class of transporters and investigated the relationships between their structures, cellular uptake efficiency, and the associated cytotoxicity. Both guanidinium heads and bulky, aromatic hydrophobic residues were found to render the cationic, amphipathic constructs more permeable. Moreover, different internalization mechanisms were observed for peptoid transporters with distinct structures. One peptoid was identified as a promising transporter with excellent cellular uptake efficiency and low cytotoxicity. (iii) Bombesin (BBN) peptide can bind with high affinity and specificity to the GRP receptors (GRPR) which are upregulated invasive prostate cancer. BBN(7-14) provides a promising basis for developing radiometallated diagnostic or therapeutic radiopharmaceuticals to target GRPR positive prostate cancer. I report a design of a 4-arm PEG-based platform with multivalent BBN(7-14) for targeted delivery to the GRPR positive prostate cancer. The PEG-BBN conjugates displayed comparable tumor uptake as the free BBN while having both a lower liver uptake and higher tumor-to-blood ratio in a biodistribution study. (iv) Regenerative medicine is in need of bioactive extracellular matrix-like scaffolds that can interact with cells and allow tissue regeneration in a well-controlled manner. Via "controlled cloning", matrix metalloproteases (MMP) degradation sites were built into multiple sites along a protein polymer that can be enzymatically crosslinked into a previously established non-bioactive hydrogel systems. The incorporation of MMP degradation sites greatly improved cell infiltration into the hydrogel. (v) Lastly, a novel in situ forming hybrid, biomimetic hydrogel comprising bioactive recombinant protein polymers, hyaluronic acid (HA) and polyethylene glycol (PEG) was developed. In a preliminary study, this hydrogel was found to be biocompatible and bioactive, which opens up future studies with this hydrogel system.
  • Digital
    edited by Luca Monticelli, Emppu Salonen.
    Springer Protocols2012
    Ab Initio, density functional theory, and semi-empirical calculations / Mikael P. Johansson, Ville R.I. Kaila, and Dage Sundholm -- Ab Initio molecular dynamics / Kari Laasonen -- Introduction to QM/MM simulations / Gerrit Groenhof -- Computational enzymology / Alessio Lodola and Adrian J. Mulholland -- QM and QM/MM simulations of proteins / Thomas Steinbrecher and Marcus Elstner -- Classical molecular dynamics in a nutshell / Susanna Hug -- Enhanced sampling algorithms / Ayori Mitsutake, Yoshiharu Mori, and Yuko Okamoto -- Force fields for classical molecular dynamics / Luca Monticelli and D. Peter Tieleman -- Polarizable force fields / Hanne S. Antila and Emppu Salonen -- Electrostatics interactions in classical simulations / G. Andres Cisneros, Volodymyr Babin, and Celeste Sagui -- Introduction to best practices in free energy calculations / Michael R. Shirts and David L. Mobley -- Recipes for free energy calculations in biomolecular systems / Mahmoud Moradi [and others] -- Molecular docking methodologies / Andrea Bortolato [and others] -- Simulation studies of the mechanism of membrane transporters / Giray Enkavi [and others] -- Molecular dynamics simulations of lipid bilayers : simple recipe of how to do it / Hector Martinez-Seara and Tomasz Rog -- Simulations of lipid monolayers / Svetlana Baoukina and D. Peter Tieleman -- Simulating DNA by molecular dynamics : aims, methods, and validation / Nicolas Foloppe, Marc Gueroult, and Brigitte Hartmann -- Simulation of carbohydrates, from molecular docking to dynamics in water / Nicolas Sapay, Alessandra Nurisso, and Anne Imberty -- Systematic methods for structurally consistent coarse-grained models / W.G. Noid -- Martini coarse-grained force field / Xavier Periole and Siewert-Jan Marrink -- Multiscale molecular modeling / Matej Praprotnik and Luigi Delle Site -- Coarse-grained models for protein folding and aggregation / Philippe Derreumaux -- Elastic network models : theoretical and empirical foundations / Yves-Henri Sanejouand -- Introduction to dissipative particle dynamics / Zhong-Yuan Lu and Yong-Lei Wang -- Multiscale molecular dynamics simulations of membrane proteins / Syma Khalid and Peter J. Bond -- Vesicles and vesicle fusion : coarse-grained simulations / Julian C. Shillcock.
  • Digital
    edited by Carole Aimé, Centre National de la Recherche Scientifique, Paris, France, Thibaud Coradin, Centre National de la Recherche Scientifique, Paris, France.
    Wiley2018
    What Are Bionanocomposites? / Agathe Urvoas, Marie Valerio-Lepiniec, Philippe Minard, Cordt Zollfrank -- Molecular Architecture of Living Matter. Nucleic Acids / Enora Prado, Mónika Ádok-Sipiczki, Corinne Nardin -- Lipids / Carole Aimé, Thibaud Coradin -- Carbohydrates / Mirjam Czjzek -- Proteins / Stéphane Romero, François-Xavier Campbell-Valois -- Functional Biomolecular Engineering. Nucleic Acid Engineering / Enora Prado, Mónika Ádok-Sipiczki, Corinne Nardin -- Protein Engineering / Agathe Urvoas, Marie Valerio-Lepiniec, Philippe Minard -- The Composite Approach. Inorganic Nanoparticles / Carole Aimé, Thibaud Coradin -- Hybrid Particles / Nikola Ž Knežević, Laurence Raehm, Jean-Olivier Durand -- Biocomposites from Nanoparticles / Carole Aimé, Thibaud Coradin -- Applications. Optical Properties / Cordt Zollfrank, Daniel Opdenbosch -- Magnetic Bionanocomposites / Wei Li, Yuehan Wu, Xiaogang Luo, Shilin Liu -- Mechanical Properties of Natural Biopolymer Nanocomposites / Biqiong Chen -- Bionanocomposite Materials for Biocatalytic Applications / Sarah Christoph, Francisco M Fernandes -- Nanocomposite Biomaterials / Gisela Solange Alvarez, Martín Federico Desimone -- A Combination of Characterization Techniques / Carole Aimé, Thibaud Coradin.
  • Digital
    Brian Michael Trantow.
    The ability of organic chemists to design and synthesize functional molecules has revolutionized the ways in which we can probe biological systems. From catalysts capable of releasing bioactive molecules from bioinactive precursors to oligomers that enable or enhance the uptake of molecules across cell membrane and cell wall barriers, the work described herein emphasizes the power of designing for function. These new tools allow for control over the location of many biologically relevant molecules, including drugs, probes, imaging agents, metabolic modulators, and pesticides, with ramifications for a variety of biochemical, agricultural, and medicinal applications. Chapter 1 reviews the development of selective catalysts designed for use in biological systems. The catalysts have primarily been used for bioconjugations, expanding the classical repertoire of bioconjugation techniques to allow for selective chemistries at many more functional groups than was traditionally possible. Emerging strategies for imaging in biological systems using transition metal catalysis are also reviewed, as are transition metal-based catalytic therapeutics. The synthesis and evaluation of a novel bioorthogonal ruthenium catalyst designed for release of biologically active molecules from inactive precursors is the focus of Chapter 2. Although the challenges associated with using transition metals in biological systems are apparent, creative design ultimately led to the development of a useful bioorthogonal catalyst / substrate pair. This system allows for real-time visualization of transition metal catalysis to generate a biologically active compound that releases photons when it encounters its intracellular enzyme target. Chapters 3 and 4 detail the synthesis and application of molecular transporter scaffolds. Chapter 3 introduces a novel organocatalytic ring-opening oligomerization of guanidinylated cyclic carbonates to access molecular transporter scaffolds in 1 step. This strategy allows for rapid access to molecular transporters of varying lengths. In addition, the synthesis allows for concomitant probe or drug attachment and the carbonate-based backbones of the resulting transporters are biodegradable on a timescale allowing for cellular uptake and intracellular degradation. The ability of molecular transporters to cross not only cell membranes, but also cell walls, is discussed in Chapter 4. These studies focused on the delivery of small molecules and proteins across the algal cell wall and cell membrane barriers using D-octaarginine-based molecular transporters. With this method, it was shown that fluorescein-octaarginine conjugates were able to cross these barriers in a variety of algal species from the class Chlorophyceae, although several species showed no uptake or only cell surface staining. It was also shown in the algal model organism Chlamydomonas reinhardtii that octaarginine-protein conjugates could cross the cell wall and cell membrane barriers to deliver a functional protein to the intracellular algal space.
  • Digital
    edited by Rajesh Krishna and Lawrence Yu.
    Springer2008
  • Digital/Print
    edited by Daniel Herschlag.
    Digital : ScienceDirectpt. A, 2009
    Digital : ScienceDirectpt. B, 2009
  • Digital
    Sean Damien Gates.
    The work presented herein is concerned with the development of biophysical methodology designed to address pertinent questions regarding the behavior and structure of select pathogenic agents. Two distinct studies are documented: a shock tube analysis of endospore-laden bio-aerosols and a correlated AFM/NanoSIMS study of the structure of vaccinia virus. An experimental method was formulated to analyze the biological and morphological response of endospores to gas dynamic shock waves. A novel laser diagnostic system was implemented to provide time resolved data concerning the structural decomposition of endospores in shock-heated flows. In addition, an ex situ methodology combining viability analysis, flow cytometry and scanning electron microscopy was employed to both assess the biological response of the endospore to the shock event, as well as to provide complementary data regarding the structural state of the treated endospore. This methodology was implemented to model the shock wave induced response of a variety of Bacillus endospores. The results are subsequently synthesized into a theoretical framework to be employed in modeling the interaction of endospore-laden bio-aerosols with blast waves. An analytical method combining atomic force microscopy (AFM) and nanometer-scale secondary ion mass spectrometry (NanoSIMS) was developed to examine the spatial localization and depth distribution of specific biological elements in viral systems. This methodology was implemented to analyze the distribution of 13C labeled fatty acids as well as 15N labeled thymidine in individual nanometer sized vaccinia viral particles. Based upon the 13C and 15N signals, three-dimensional depth-resolved data regarding the architecture and localization of the virion lipid membrane and the nucleoprotein complex was generated. In addition, this methodology was employed to provide direct correlation of architectural and chemical data for isolated sub-viral structures. The technique and results presented herein represent a novel tool for the structural and chemical study of both intact viral particles as well as specifically targeted sub-viral elements.
  • Digital
    Jonathan D. Dinman, editor.
    Springer2013
    When quantum mechanics was first proposed a century ago, nobody could have anticipated how deeply it would affect our lives. Today, we are connected and powered through devices whose existence is predicated on the basic principles of this strange physics. Not even the biological sciences have escaped its reach. As scientists query the deepest mysteries of the living world, the physical scales probed and the types of questions asked are increasingly blurring the lines between biology and physics. The hybrid field of biophysics represents the new frontier of the 21st century. The ribosome has been at the heart of three Nobel Prizes. Understanding its essential nature and how it interacts with other proteins and nucleic acids to control protein synthesis has been one of the central foundations in our understanding of the biology at the molecular level. With the advent of atomic scale structures, methods to visualize and separate individual molecules, and the computational power to model the complex interactions of over a million atoms at once, our understanding of how gene expression is controlled at the level of protein translation is now deeply ensconced in the biophysical realm. This book provides a premier resource to a wide audience, whether it be the general reader seeking a broad view of the field, a clinician interested in the role of protein translation in human disease, the bench researcher looking for state-of-the-art technologies, or computational scientists involved in cutting edge molecular modeling.
  • Print
    John T. Edsall, Jeffries Wyman.
    Status: Not Checked OutLane Catalog Record
  • Digital
    Alan Cooper.
    Knovel2012
    1. Biological molecules -- 2. Spectroscopy -- 3. Mass spectrometry -- 4. Hydrodynamics -- 5. Thermodynamics and interactions -- 6. Kinetics -- 7. Chromatography and electrophoresis -- 8. Imaging -- 9. Single molecules.
  • Digital
    Engelbert Buxbaum
    Springer2011
  • Digital
    edited by Ewa K. Paluch.
    ScienceDirect2015
  • Digital/Print
    edited by John J. Correia, H. William Detrich, III.
    Digital : ScienceDirect2008
    Print2008
  • Digital/Print
    edited by John Correia and H. William Detrich, III.
    Digital : ScienceDirect2008
    Print2008
  • Digital
    Allewell, Norma M.
  • Digital
    Linda O. Narhi, editor.
    Springer2013
    This book can be used to provide insight into this important application of biophysics for those who are planning a career in protein therapeutic development, and for those outside this area who are interested in understanding it better. The initial chapters describe the underlying theory, and strengths and weaknesses of the different techniques commonly used during therapeutic development. The majority of the chapters discuss the applications of these techniques, including case studies, across the product lifecycle from early discovery, where the focus is on identifying targets, and screening for potential drug product candidates, through expression and purification, large scale production, formulation development, lot-to-lot comparability studies, and commercial support including investigations.
  • Digital/Print
    Mark C. Leake, editors.
    Digital : Springer2016
    Print2016
    The biophysics of infection / Mark C. Leake -- Single-molecule observation of DNA replication repair pathways in E. coli / Adam J.M. Wollman, Aisha H. Syeda, Peter McGlynn and Mark C. Leake -- Investigating the swimming of microbial pathogens using digital holography / K.L. Thornton, R.C. Findlay, P.B. Walrad and L.G. Wilson -- What is the 'minimum inhibitory concentration' (mic) of pexiganan acting on escherichia coli?--a cautionary case study / Alys K. Jepson, Jana Schwarz-Linek, Lloyd Ryan, Maxim G. Ryadnov and Wilson C.K. Poon -- Evolution of drug resistance in bacteria / B. Waclaw -- Using biophysics to monitor the essential protonmotive force in bacteria / Mei-Ting Chen and Chien-Jung Lo -- The Type I restriction enzymes as barriers to horizontal gene transfer: determination of the DNA target sequences recognised by livestock-associated methicillin-resistant Staphylococcus aureus clonal complexes 133/ST771 and 398 / Kai Chen, Augoustinos S. Stephanou, Gareth A. Roberts, John H. White, Laurie P. Cooper, Patrick J. Houston, Jodi A. Lindsay and David T.F. Dryden -- Biomechanical analysis of infectious biofilms / David Head -- Designing a single-molecule biophysics tool for characterising DNA damage for techniques that kill infectious pathogens through DNA damage effects / Helen Miller, Adam J.M. Wollman and Mark C. Leake -- Bacterial surfaces: front lines in host-pathogen interaction / Jane E. King and Ian S. Roberts -- Biophysical approaches to bacterial gene regulation by riboswitches / Cibran Perez-Gonzalez, Jonathan P. Grondin, Daniel A. Lafontaine and J. Carlos Penedo -- Bugs on a slippery plane / Dmitri O. Pushkin and Martin A. Bees -- Transcription regulation and membrane stress management in enterobacterial pathogens / Nan Zhang, Goran Jovanovic, Christopher McDonald, Oscar Ces, Xiaodong Zhang and Martin Buck -- How biophysics may help us understand the flagellar motor of bacteria which cause infections / Matthew A.B. Baker -- Mechanics of bacterial cells and initial surface colonization / Sebastian Aguayo and Laurent Bozec -- Neutron reflectivity as a tool for physics-based studies of model bacterial membranes / Robert D. Barker, Laura E. McKinley and Simon Titmuss -- Mechanisms of Salmonella typhi host restriction / Stefania Spanò --Insights into biological complexity from simple foundations / L. Albergante, D. Liu, S. Palmer and T.J. Newman -- Force spectroscopy in studying infection / Zhaokun Zhou and Mark C. Leake -- Imaging immunity in lymph nodes: past, present and future / James Butler, Amy Sawtell, Simon Jarrett, Jason Cosgrove, Roger Leigh, Jon Timmis and Mark Coles -- Novel approaches to manipulating bacterial pathogen biofilms: whole-systems design philosophy and steering microbial evolution / Alexandra S. Penn -- Index.
  • Digital
    John Golbeck, Art van der Est, editors.
    Springer2014
    "The volume is intended as an introduction to the physical principles governing the main processes that occur in photosynthesis, with emphasis on the light reactions and electron transport chain. A unique feature of the photosynthetic apparatus is the fact that the molecular structures are known in detail for essentially all of its major components. The availability of this data has allowed their functions to be probed at a very fundamental level to discover the design principles that have guided evolution. Other volumes on photosynthesis have tended to focus on single components or on a specific set of biophysical techniques, and the authors' goal is to provide new researchers with an introduction to the overall field of photosynthesis. The book is divided into sections, each dealing with one of the main physical processes in photosynthetic energy conversion. Each section has several chapters each describing the role that a basic physical property, such as charge or spin, plays in governing the process being discussed. The chapters proceed in an orderly fashion from a quantum mechanical description of early processes on an ultrafast timescale to a classical treatment of electron transfer and catalysis on a biochemical timescale culminating in evolutionary principles on a geological timescale."--Publisher's website.
  • Digital
    Rick Russell, editor.
    Springer2013
    Structured RNAs are everywhere, functioning throughout gene expression with key roles ranging from catalysis to regulation. New functional RNAs are being discovered all the time; in fact, it is now clear that a much greater fraction of eukaryotic genomes is devoted to coding for RNA than protein. Many of these RNAs must traverse complex energy landscapes to find their functional three-dimensional structures. Along the way, they may encounter native and non-native folding intermediates, chaperone proteins, and assemble with partner proteins. This volume, written by experts in the field, discusses the current understanding of the biophysical principles that govern RNA folding, with featured RNAs including the ribosomal RNAs, viral RNAs, and self-splicing introns. In addition to the fundamental features of RNA folding, the central experimental and computational approaches in the field are presented with an emphasis on their individual strengths and limitations, and how they can be combined to be more powerful than any method alone; these approaches include NMR, single molecule fluorescence, site-directed spin labeling, structure mapping, comparative sequence analysis, graph theory, course-grained 3D modeling, and more. This volume will be of interest to professional researchers and advanced students entering the field of RNA folding.
  • Digital
    edited by Ilina Singh, Walter P. Sinnott-Armstrong, Julian Savulescu.
    OSO2013
    Foreword / Philip Campbell -- Contributors -- Introduction : deviance, classification, and bioprediction / Ilina Singh and Walter P. Sinnott-Armstrong -- Behavioral biomarkers : what are they good for? : toward the ethical use of biomarkers / Matthew Baum and Julian Savulescu -- Bioprediction in youth justice / Charlotte K. Walsh -- The inclusion of biological risk factors in violence risk assessments / John Monahan -- Bioprediction in criminal cases / Christopher Slobogin -- The limits of legal use of neuroscience / Colin Campbell and Nigel Eastman -- Rethinking the implications of discovering biomarkers for biologically based criminality / Paul Root Wolpe -- MAOA and the bioprediction of antisocial behavior : science fact and science fiction / Joshua W. Buckholtz and Andreas Meyer-Lindenberg -- Genetic biomarker research of callous-unemotional traits in children : implications for the law and policymaking / Essi Viding and Eamon McCrory -- The neural code for intentions in the human brain / John-Dylan Haynes -- Biomarkers : potentials and challenges / Michael Rutter -- Neuroimaging-based automatic classification of schizophrenia / Vince D. Calhoun and Mohammad R. Arbabshirani -- Index.
  • Digital
    edited by Iris Hunger, Vladan Radosavljevic, Goran Belojevic, Lisa D. Rotz.
    Springer2013
    The terrorist use of diseases as bioweapons has been one of the major security concerns in recent years, particularly after the anthrax letter attacks in the USA in 2001. This uncertain threat of intentional outbreaks of diseases exists side by side with the constantly changing very real threat from diseases, epidemics and pandemics as recently illustrated by the H1N1 influenza pandemic, SARS, and H5N1 bird influenza events. This publication contains case studies on the public health planning for (un)usual disease outbreaks for 11 large and small countries with a focus on South Eastern Europe. In many countries, military entities traditionally play an important role in emergency response to disease outbreaks. In smaller countries, very little exists, however, in terms of specific biopreparedness efforts (in both the military and civilian area), which is at least partly due to a relatively low bioterrorism threat perception, and serious resource constraints. The uncertainty associated with the bioterrorism threat makes public health preparedness planning for such events politically and financially very difficult. The similarity of responding to bioterrorism events and natural disease outbreaks from a public health point of view suggests the merit of looking at biopreparedness as a part of overall health emergency planning, not as a separate effort.
  • Digital
    Maika G. Mitchell.
    ScienceDirect2017
    Innovation is added value to a known process. Bioprinting: Techniques and Risks for Regenerative Medicine aims to stimulate a scientifically grounded, interdisciplinary, multiscale debate and exchange of ideas using the techniques described in the book. 3D printing and additive manufacturing evolved from within the field of Cell Biology will have the ability to recreate cells queried from large amounts of phenotypic and molecular data. Stem Cell biologists, biotechnologists and material engineers, as well as graduate students will greatly benefit from the practical knowledge and case examples provided throughout this book.
  • Digital
    [edited] by Che J. Connon.
    Wiley2017
    Bioprocessing for cell based therapies -- Structured methodology for process development in scalable stirred tank bioreactors platforms -- The effect of scale-up on cell phenotype : compatibility testing to optimize bioreactor usage and manufacturing strategies -- The scale-up of human mesenchymal stem cell expansion and recovery -- Challenges of scale-up of cell separation and purification techniques -- Fundamental points to consider in the cryopreservation and shipment of cells for human application -- Short-term storage of cells for application in cell-based therapies -- Cell therapy in practice.
  • Digital
    by Juan M Bilbao, Robert E Schmidt.
    Springer2015
    Peripheral nerve analysis is a challenging task for pathologists, given the advent of new diagnoses and techniques of analysis and the impact of molecular genetics. This book presents a simple, logical method for constructing a differential diagnosis based on pathology and clinical presentation. It also provides advice on the selection of ancillary molecular, immunohistochemical and genetic techniques to establish a definitive diagnosis. Clear, authoritative guidance is offered on diagnosis of the full range of neuropathies with the aid of a wealth of high-quality color photomicrographs and electron micrographs. The pathologist will benefit greatly from the identification of a variety of artifacts and normal structures occasionally encountered in nerve biopsies that need to be distinguished from specific pathologic alterations. This user-friendly, practical text will be an invaluable aid in achieving the most specific diagnosis possible.
  • Digital
    Cyril Fisher, Elizabeth A. Montgomery, Khin Thway.
    Ovid2016
    Biopsy techniques, diagnostic methods, and reporting -- Benign and intermediate fibrosing lesions -- Cellular benign and intermediate lesions of fibroblasts and myofibroblasts -- Cutaneous spindle cell lesions -- Intra-abdominal spindle cell lesions -- Smooth muscle tumors -- Myofibroma, myopericytic tumors, myoepithelioma, and myofibroblastoma -- Tumors of specialized lower genital tract mesenchyme -- Benign nerve sheath tumors -- Spindle cell sarcomas -- Epithelioid tumors of soft tissue -- Soft tissue lesions with clear or granular cells -- Pleomorphic soft tissue tumors -- Small round cell tumors -- Benign adipose tissue lesions -- Liposarcoma -- Superficial vascular lesions and mimics of vascular lesions -- Deep vascular lesions -- Osteochondroid lesions of soft tissue -- Superficial myxoid lesions -- Deep myxoid lesions -- Plexiform soft tissue tumors -- Soft tissue tumors with giant cells.
  • Digital
    Jonathan I. Epstein, MD, Professor of Pathology, Urology and Oncology, The Reinhard Professor of Urological Pathology, Director of Surgical Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland, Victor E. Reuter, MD, Attending Pathologist and Member, Memorial Sloan Kettering Cancer Center, Professor of Pathology and Laboratory Medicine, Weill Medical College of Cornell University, New York, New York, Mahul B. Amin, MD, Profesor and Chairman Emeritus, Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Professor of Pathology and Laboratory Medicine, UCLA David Geffen School of Medicine, Visiting Professor, Urology, USC Keck School of Medicine, Los Angeles, California, Visiting Professor, Pathology & Immunology, Baylor College of Medicine, Houston, Texas.
    Ovid2017
    Normal bladder anatomy and variants of normal histology -- Flat urothelial lesions -- Papillary urothelial neoplasms and their precursors -- Urothelial neoplasms with inverted growth patterns -- Invasive urothelial carcinoma -- Histologic variants of urothelial carcinoma -- Conventional morphologic, prognostic, and predictive factors and reporting of bladder cancer -- Glandular lesions -- Squamous lesions -- Cystitis -- Mesenchymal tumors and tumor-like lesions -- Miscellaneous non-tumors & tumors -- Secondary tumors of the bladder -- Urinary tract cytopathology.
  • Digital
    Stuart J. Schnitt, Laura C. Collins.
    Ovid2018
    Normal anatomy and histology -- Reactive, inflammatory, and nonproliferative lesions -- Intraductal proliferative lesions : usual ductal hyperplasia, atypical ductalhyperplasia, and ductal carcinoma in situ -- Columnar cell lesions and flat epithelial atypia -- Lobular carcinoma in situ and atypical lobular hyperplasia -- Fibroepithelial lesions -- Adenosis and sclerosing lesions -- Papillary lesions -- Microinvasive carcinoma -- Invasive breast cancer -- Spindle cell lesions -- Vascular lesions -- Other mesenchymal lesions -- Miscellaneous rare lesions -- Nipple disorders -- Male breast lesions -- Breast lesions in children and adolescents -- Axillary lymph nodes -- Treatment effects -- Specimen processing, evaluation, and reporting.
  • Digital
    Matthew J. Schniederjan.
    Ovid2018
    Benign cysts and selected developmental anomalies -- Inflammatory and infectious lesions -- Diffuse gliomas -- Other astrocytomas -- Ependymal tumors -- Other gliomas -- Neuronal and mixed glioneuronal tumors -- Sellar and suprasellar lesions -- Meningeal lesions -- Embryonal tumors -- Choroid plexus tumors -- Pineal region tumors -- Cranial and spinal nerve tumors -- Vascular malformations -- Germ cell tumors -- Hematolymphoid neoplasms -- Select tumors of indeterminate or mesenchymal differentiation -- Metastases -- Intraoperative consultation -- General approach and differential diagnosis.
  • Digital
    Michael S. Torbenson, Professor of Pathology, Senior Associate Consultant, Division of Anatomic Pathology, Mayo Clinic, Rochester, Minnesota.
    Ovid2015
    General approach to biopsy assessment -- General approach to biopsy reports -- The almost normal liver biopsy -- Liver injury patterns -- Acute and chronic viral hepatitis -- Other infections of the liver -- Granulomatous disease -- Drug effects -- Fatty liver disease -- Autoimmune hepatitis -- Biliary tract disease and cholestatic liver disease -- Pediatric cholestatic liver disease -- Vascular disease -- Transplant pathology -- Iron overload disease -- Wilson disease and other genetic diseases -- Liver disease in systemic conditions -- Pediatric benign and malignant tumors -- Adult benign and malignant mesenchymal tumors -- Benign and malignant hepatocellular tumors -- Benign and malignant biliary tumors -- Other tumors of the liver.
  • Digital
    Scott Boerner, MD, FRCPC, Director, Cytopathology, University Health Network, Associate Professor, Department of Laboratory Medicine and Pathobiology, University of Toronto, Ontario, Canada, Sylvia L. Asa, MD, PhD, Senior Scientist, Department of Pathology, University Health Network, Professor, Department of laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.
    Ovid2017
    The normal thyroid -- The classification of thyroid pathology -- The cytologic approach to diagnosis of thyroid pathology : technical aspects -- The histologic biopsy of thyroid : technical aspects -- Ancillary tools in thyroid diagnosis -- Cystic lesions -- Inflammatory and lymphoid lesions -- Papillary lesions -- Follicular lesions -- Solid and trabecular lesions -- Squamoid, spindle, and giant-cell lesions -- Small cell lesions.
  • Digital
    edited by Avraham Rasooly and Keith E. Herold.
    Springer Protocolsv. 1, 2009
    Springer Protocolsv. 2, 2009
    V. 1. Optical-based detectors. Pt. I. Optical-based detectors. Surface plasmon resonance and surface plasmon field-enhanced fluorescence spectroscopy for sensitive detection of tumor markers / Yusuke Arima ... [et al.] -- Surface plasmon resonance biosensor for biomolecular interaction analysis based on spatial modulation phase detection / Xiang Ding, Fangfang Liu, and Xinglong Yu -- Array-based spectral SPR biosensor: analysis of mumps virus infection / Jong Seol Yuk and Kwon-Soo Ha -- Optical biosensors based on photonic crystal surface waves / Valery N. Konopsky and Elena V. Alieva -- Surface plasmon resonance biosensing / Marek Piliarik, Hana Vaisocherová, and Jiří Homola -- Label-free detection with the resonant mirror biosensor / Mohammed Zourob ... [et al.] -- Label-free detection with the liquid core optical ring resonator sensing platform / Ian M. White ... [et al.] -- Reflectometric interference spectroscopy / Guenther Proll ... [et al.] -- Phase sensitive interferometry for biosensing applications / Digant P. Davé -- Label-free serodiagnosis on a grating coupler / Thomas Nagel, Eva Ehrentreich-Förster, and Frank F. Bier -- Pt. II. Indirect detectors. CCD camera detection of HIV infection / John R. Day -- Integrating waveguide biosensor / Shuhong Li ... [et al.] -- Detection of fluorescence generated in microfluidic channel using in-fiber grooves and in-fiber microchannel sensors / Rudi Irawan and Swee Chuan Tjin -- Multiplex integrating waveguide sensor: SignalyteTM-II / Shuhong Li ... [et al.] -- CCD based fiber-optic spectrometer detection / Rakesh Kapoor -- V. 2. Electrochemical and mechanical detectors, lateral flow and ligands for biosensors. Pt. I. Mechanical detectors. A set of piezoelectric biosensors using cholinesterases / Carsten Teller ... [et al.] -- Piezoelectric biosensors for aptomer-protein interaction / Sara Tombelli ... [et al.] -- Piezoelectric quartz crystal resonators applied for immunosensing and affinity interaction studies / Petr Skládal -- Biosensors based on cantilevers / Mar Alvarez ... [et al.] -- Piezoelectric-excited millimeter-sized cantilever biosensors / Raj Mutharasan -- Pt. II. Electrochemical detectors. Preparation of screen-printed electrochemical immunosensors for estradiol, and their application in biological fluids / Roy M. Pemberton and John P. Hart -- Electrochemical DNA biosensors: protocols for intercalator-based detection of hybridization in solution and at the surface / Kagan Kerman, Mun'delanji Vestergaard, and Eiichi Tamiya -- Electrochemical biosensor technology: application to pesticide detection / Ilaria Palchetti, Serena Laschi, and Marco Mascini -- Electrochemical detection of DNA hybridization using micro and nanoparticles / María Teresa Castañeda, Salvador Alegret, and Arben Merkuçi -- Electrochemical immunosensing using micro and nanoparticles / Alfredo de la Escosura-Muñiz ... [et al.] -- Methods for the preparation of electrochemical composite biosensors based on gold nanparticles / A. González-Cortés, P. Yáñez-Sedeño, and J.M. Pingarrón -- Pt. III. Lateral flow. Immunochromatographic lateral flow strip tests / Gaiping Zhang, Junqing Guo, Xuannian Wang -- Liposome-enhanced lateral-flow assays for the sandwich-hybridization detection of RNA / Katie A. Edwards and Antje J. Baeumner -- Rapid prototyping of lateral flow assays / Alexander Volkov ... [et al.] -- Lateral flow colloidal gold-based immunoassay for pesticide / Shuo Wang, Can Zhang, and Yan Zhang -- Pt. IV. Ligands. Synthesis of a virus electrode for measurement of prostate specific membrane antigen / Juan E. Diaz ... [et al.] -- Simple luminescence detector for capillary electrophoresis / Antonio Segura-Carretero, Jorge F. Fernández-Sánchez, and Alberto Fernández-Gutiérrez -- Optical system design for biosensors based on CCD detection / Douglas A. Christensen and James N. Herron --A simple portable electroluminescence illumination-based CCD detector / Yordan Kostov ... [et al.] -- Fluoroimmunoassays using the NRL array biosensor / Joel P. Golden and Kim E. Sapsford -- Biosensors technologies: acousto-optic tunable filter-based hyperspectral and polarization images for fluorescence and spectroscopic imaging / Neelam Gupta -- Photodiode-based detection system for biosensors / Yordan Kostov -- Photodiode array on-chip biosensor for the detection of E. coli O157:H7 pathogenic bacteria / Joon Myong Song and Ho Taik Kwon -- DNA analysis with a photo-diode array sensor / Hideki Kambara and Guohua Zhou -- Miniaturized and integrated fluorescence detectors for microfluidic capillary electrophoresis devices / Toshihiro Kamei -- Photomultiplier tubes in biosensors / Yafeng Guan -- In vivo bacteriophage display for the discovery of novel peptide-based tumor-targeting agents / Jessica R. Newton and Susan L. Deutscher -- Biopanning of phage displayed peptide libraries for the isolation of cell-specific ligands / Michael J. McGuire, Shunzi Li, and Kathlynn C. Brown -- Biosensor detection systems: engineering stable, high-affinity bioreceptors by yeast surface display / Sarah A. Richman, David M. Kranz, and Jennifer D. Stone -- Antibody affinity optimization using yeast cell surface display / Robert W. Siegel -- Using RNA aptamers and the proximity ligation assay for the detection of cell surface antigens / Supriya S. Pai and Andrew D. Ellington -- In vitro selection of protein-binding DNA aptamers as ligands for biosensing applications / Naveen K. Navani, Wing Ki Mok, and Yingfu Li -- Pt. V. Protein and DNA preparation. Immobilization of biomolecules onto silica and silica-based surfaces for use in planar array biosensors / Lisa C. Shriver-Lake, Paul T. Charles, and Chris R. Taitt -- Rapid DNA amplification using a battery-powered thin-film resistive thermocycler / Keith E. Herold ... [et al.].
  • Digital
    edited by Zeynep Altintas.
    Wiley2018
    General introduction to biosensors and recognition receptors -- Biomarkers in health care -- The use of nanomaterials and microfluidics in medical diagnostics -- SPR-based biosensor technologies in disease detection and diagnostics -- Piezoelectric-based biosensor technologies in disease detection and diagnostics -- Electrochemical-based biosensor technologies in disease detection and diagnostics -- MEMS-based cell counting methods -- Lab-on-a-chip platforms for disease detection and diagnosis -- Applications of quantum dots in biosensors and diagnostics -- Applications of molecularly imprinted nanostructures in biosensors and diagnostics -- Smart nanomaterial's : applications in biosensors and diagnostics -- Applications of magnetic nanomaterial's in biosensors and diagnostics -- Graphene applications in biosensors and diagnostics -- Optical biosensors and applications to drug discovery for cancer cases -- Biosensors for detection of anticancer drug-DNA interactions.
  • Digital
    edited by Ashutosh Tiwari and Anthony P.F. Turner.
    Wiley2014
    "This book provides detailed review chapters on a range of nanostructures such as nanoparticles, nanowires, nanotubes, nanoribbons, nanorods, nanobelts and nanosheets in the construction of biosensors with set applications of biosensors nanotechnology for biological and chemical analyses, food safety industry, biomedical diagnostics, clinical detection, and environmental monitoring. The authors provide a comprehensive view of cutting-edge research on advanced materials for healthcare technology and applications. The book is written for scientists, researchers, and clinicians from diverse backgrounds across chemistry, physics, materials science and engineering, medical science, pharmacy, biotechnology, and biomedical engineering"--Provided by publisher.
  • Digital
    editors, Kerry B. Barker, Sandeep M. Menon, Ralph B. D'Agostino, Sr., Siyan Xu, Bo Jin.
    TandFonline2017
    1. Biosimilars for drug development : the time is now! / Bo Jin, Sandeep M. Menon, Kerry B. Barker, and Ralph B. D'Agostino -- 2. From isolation to integration : a systems biology approach for the discovery of therapeutic targets and biomarkers / Attila Seyhan and Claudio Carini -- 3. Immunogenicity of biological products : current perspectives and future implications / Candida Fratazzi, Attila Seyhan, and Claudio Carini -- 4. Interchangeability between biosimilar and innovator drug products / Bo Jin, Sandeep M. Menon, Kerry B. Barker, and Steven Ye Hua -- 5. Bridging a new biological product with its reference product / Jianfun (David) Li and Jin Xu -- 6. Accounting for covariate effect to show noninferiority in biosimilars / Siyan Xu, Kerry B. Barker, Sandeep M. Menon, and Ralph B. D'Agostino -- 7. Novel method in inference of equivalence in biosimilars / Siyan Xu, Steven Ye Hua, Ronald Menton, Kerry B. Barker, Sandeep M. Menon, and Ralph B. D'Agostino -- 8. Multiplicity adjustments in testing for bioequivalence / Steven Ye Hua, Siyan Xu, and Ralph B. D'Agostino -- 9. Bayesian methods to assess bioequivalence and biosimilarity with case studies / Steven Ye Hua, Siyan Xu, Kerry B. Barker, Shan Mei Liao, and Shujie Li -- 10. Average inferiority measure and standardized margins to address the issues in biosimilar trials / Gang Li and Weichung Joe Shih -- 11. Bayesian methods for design and analysis of noninferiority trials / Mani Lakshminarayanan and Fanni Natanegara.
  • Digital
    Andrew W. Mulcahy, Jakub P. Hlavka, Spencer R. Case.
    "The Biologics Price Competition and Innovation Act (BPCIA), enacted as part of the 2010 Patient Protection and Affordable Care Act (ACA), authorized the U.S. Food and Drug Administration (FDA) to create a new regulatory approval pathway for biosimilars, which are biologic drugs that are very similar to already approved "reference" biologics in terms of potency, safety, and efficacy, but are manufactured by different companies. In the seven years since the ACA, many drug manufacturers worked to push new biosimilars through development and FDA review. As of July 2017, there were three marketed biosimilars and two more that were approved by the FDA but not yet marketed. BPCIA's shorter, lower-cost biosimilar approval pathway was designed to introduce competition among biologic manufacturers. This Perspective estimates potential future savings from biosimilars in the United States, summarizes the experience to date with the first marketed biosimilar in the United States, and discusses key policy issues surrounding biosimilars. We estimate that biosimilars will reduce direct spending on biologic drugs by $54 billion from 2017 to 2026, or about 3 percent of total estimated biologic spending over the same period, with a range of $24 to $150 billion. While our estimate uses recent data and transparent assumptions, we caution that actual savings will hinge on industry and regulatory decisions as well as potential policy changes to strengthen the biosimilar market"--Publisher's description.
  • Digital
    Jean-Louis Prugnaud, Jean-Hugues Trouvin, editors.
    Springer2013
    Biologicals' Characteristics / K. Ho and J.-H. Trouvin -- From the Biosimilar Concept to the Marketing Authorisation / M. Pavlovic and J.-L. Prugnaud -- Immunogenicity / J.-L. Prugnaud -- Substitution and Interchangeability / J.-L. Prugnaud -- G-CSFs: Onco-Hematologist's Point of View / D. Kamioner -- The Oncologist's Point of View / C. Chouaïd -- Biosimilars: Challenges Raised by Biosimilars: Who is Responsible for Cost and Risk Management? / F. Megerlin.
  • Digital
    edited by Cheng Liu, K. John Morrow Jr.
    Wiley2017
    The history of therapeutic monoclonal antibodies / Regis Sodoyer -- Structure, classification and naming of therapeutic monoclonal antibodies / Zhinan Xia -- Mechanism of action for therapeutic antibodies / Yu Zhou and James D. Marks -- Therapeutic monoclonal antibodies and their targets / Maurizio Chiriva-Internati, et al -- Antibody post-translational modifications / Roy Jefferis -- The pharmacology, pharmacokinetics, and pharmacodynamics of antibodies / Ningning Xu, Meimei Liu, Margaret Liu -- Monoclonal antibodies : applications in clinical oncology / Jeanene ("Gigi") Robison -- Development of biosimilar rituximab and clinical experience / Reena Nair -- Monoclonal antibodies for infectious diseases / Steven J. Projan -- Monoclonal antibodies for musculoskeletal, CNS, and other diseases / Junming Yie and Tao Wu -- Manufacture of recombinant therapeutic proteins using chinese hamster ovary cells in large-scale bioreactors : history, methods and perspectives / Florian M. Wurm and Maria De Jesus -- Process development / Samuel D. Stimple and David W. Wood -- Biosimilars and biobetters : impact on biopharmaceutical manufacturing and CMOs / Ronald A. Rader -- Cell line and cell culture development for biosimilar antibody drug manufacturing / Jianguo Yang -- Product analysis of biosimilar antibodies / Weidong Jiang, Scott Liu and Ziyang Zhong -- Bioanalytical development / Rafiq Islam -- Preclinical and clinical development of biosimilar antibodies / João Eurico Fonseca and João Gonçalves -- Regulatory issues / Clarinda Islam -- Legal considerations / K. Lance Anderson, Jennifer R. Moore Meline, and Jonathan D. Ball -- ADCC enhancement technologies for next generation therapeutic antibodies / Cheng Liu and Su Yan -- Biosimilar antibody half-life : engineering for optimal performance / K. John Morrow, Jr -- Technologies for antibody drug conjugation / Patrick G. Holder and David Rabuka.
  • Digital
    Erik Mosekilde, Olga Sosnovtseva, Amin Rostami-Hodjegan, editors.
    Springer2012
  • Digital
    Alan Booth, Susan M. McHale, Nancy S. Landale, editors.
    Springer2011
    "Genes and environment. Biology and behavior. Nature and nurture. The terminology may be clear-cut, but the processes themselves are far from simple: unlike the direct cause-and-effect dichotomies of past frameworks, researchers now recognize these family-based connections as multifaceted, transactional, and emergent. [This book] aims at illuminating a multiplicity of approaches and methodologies for studying family dynamics, to match the complex interplay of physiological factors, environmental challenges, and behavioral adaptations that characterize family life and development. Chapters illustrate physical and social influences on parenting, childhood, adolescence, fertility, and family formation, providing analytical frameworks for understanding key areas such as family behavior, health, development, and adaptation to contextual stressors."--Book jacket.
  • Digital
    Annemarie Surlykke, Paul E. Nachtigall, Richard R. Fay, Arthur N. Popper, editors.
    Springer2014
    1. Biosonar of Bats and Toothed Whales: An Overview / Annemarie Surlykke and Paul E. Nachtigall -- 2. Sonar Signals of Bats and Toothed Whales / Brock (M. B.) Fenton, Frants H. Jensen, Elisabeth K. V. Kalko, and Peter L. Tyack -- 3. Production of Biosonar Signals: Structure and Form / Whitlow W. L. Au and Roderick A. Suthers -- 4. Sound Intensities of Biosonar Signals from Bats and Toothed Whales / Magnus Wahlberg and Annemarie Surlykke -- 5. Hearing During Echolocation in Whales and Bats / Paul E. Nachtigall and Gerd Schuller -- 6. Localization and Classification of Targets by Echolocating Bats and Dolphins / James A. Simmons, Dorian Houser, and Laura Kloepper -- 7. On-Animal Methods for Studying Echolocation in Free-Ranging Animals / Mark Johnson -- 8. Analysis of Natural Scenes by Echolocation in Bats and Dolphins / Cynthia F. Moss, Chen Chiu, and Patrick W. Moore -- 9. Echolocation in Air and Water / Peter Teglberg Madsen and Annemarie Surlykke.
  • Print
    Wayne W. Daniel.
    Status: Not Checked OutLane Catalog Record
  • Print
    Geoffrey R. Norman, David L. Streiner.
    Status: Not Checked OutLane Catalog Record
    The nature of data and statistics -- Analysis of variance -- Regression and correlation -- Nonparametric statistics -- Reprise.
  • Digital
    Christophe Lalanne, Mounir Mesbah.
    ScienceDirect2017
    1. Language elements -- 2. Simple descriptive statistics -- 3. Measures of association, comparison of means or proportions -- 4. Correlation, linear regression -- 5. Logistic regression -- 6. Survival curves, cox regression -- Appendix A. Introduction to SAS studio -- Appendix B. Introduction to SAS Macro -- Appendix C. Introduction to SAS IML.
  • Digital
    Daryl S. Paulson.
    Springer2008
  • Digital
    Francesco Sardanelli, Giovanni Di Leo.
    Springer2009
  • Print
    contributors: A. L. Delaunois ... [et al.].
    Status: Not Checked OutLane Catalog Record
  • Digital/Print
    edited by Ramkrishna Sen.
    Digital : Springer2010
    Print2010
  • Digital
    Gloria Soberón-Chávez, editor.
    Springer2011
    Biosurfactants: A General Overview / Gloria Soberón-Chávez and Raina M. Maier -- Rhamnolipids: Detection, Analysis, Biosynthesis, Genetic Regulation, and Bioengineering of Production / Ahmad Mohammad Abdel-Mawgoud, Rudolf Hausmann, Francois Lépine, Markus M. Müller and Eric Déziel -- Surfactin and Other Lipopeptides from Bacillus spp. / Philippe Jacques -- Serrawettins and Other Surfactants Produced by Serratia / Tohey Matsuyama, Taichiro Tanikawa and Yoji Nakagawa -- Trehalolipids / Zongze Shao -- Mannosylerythritol Lipids: Microbial Production and Their Applications / J. Arutchelvi and M. Doble -- Sophorolipids / Inge N. A. Van Bogaert and Wim Soetaert.
  • Digital
    Fong Tian Wong.
    Polyketide synthases (PKSs) are multi-functional enzymes, which synthesize natural products known as polyketides. These complex molecules have a diverse range of medicinal properties. Biosynthetic engineering of the multi-modular PKSs is attractive due to their modularity and colinearity, which, if understood at the molecular level, could allow for the efficient and predictable regioselective chemical manipulation of polyketides. A minimum combination of a [beta]-ketosynthase (KS), an acyltransferase (AT), and an acyl carrier protein (ACP) is required for the assembly of acyl-CoA precursors into complex polyketide products. This work will focus on AT domains, which are the primary gatekeepers for stepwise incorporation of acyl-CoA building blocks into a growing polyketide chain. In our initial investigations, protein interactions between AT, ACP and flanking AT linkers from a prototypical multimodular 6-deoxyerythronolide B synthase (DEBS) were systematically explored, guided by recent high-resolution structures. Our results indicate that N/C terminal linkers of the modular DEBS AT domain contributed to both efficiency and specificity of transacylation. Representative DEBS AT3 and AT6 domains were also observed to have greater than 10-fold AT specificities for their cognate ACP substrates as compared to other ACPs in the DEBS PKS. In comparison, there is only modest discrimination for its native ACP by the standalone AT from the "AT-less" disorazole synthase (DSZS). These "AT-less" multimodular PKS lack AT domains in their modular assembly, and instead, transacylation is supplied by a trans-acting discrete AT. With its higher transacylation activity for DEBS ACPs compared to their natural ATs (> 40-fold), DSZS AT presents new opportunities for regioselective modification of a polyketide backbone and thus prompting further structural and biochemical investigations. Towards the analysis of DSZS AT, we report crystal structures of trans-acting AT resolved at 1.51 Å, and that of its acetate complex at 1.35 Å resolution. Comprehensive alanine-scanning mutagenesis of its native ACP1 substrate also identified a conserved Asp45 residue on the ACP for AT interactions. This conserved residue is proposed to contribute to the observed AT promiscuity. Supplementing in silico protein docking with these results, a model for DSZS AT and ACP interactions was derived. Working towards high-resolution structural characterization of this interface, we developed a novel strategy for covalently cross-linking and purifying a catalytically relevant DSZS AT-ACP complex. Finally, trans complementation of methylmalonyl CoA specific DEBS modules was also accomplished in vitro with DSZS AT for malonyl CoA incorporation. From our investigations, we have gained new insights into the protein-protein interactions that play a major role in the efficient biosynthesis of structurally complex polyketides. These results also reveal important considerations and opportunities for biosynthetic engineering within the multi-functional assembly lines.
  • Print
    George R. Pettit.
    Status: Not Checked OutLane Catalog Record
  • Digital
    Gail Baura.
  • Digital
    Mauro Bologna, editor.
    Springer2012
    Central Nervous System Tumors / Paolo Aloisi, Francesco Martella, Davide Cerone and Giampiero Porzio -- Head and Neck Tumours / Keith D. Hunter and Robert Bolt -- Thyroid Cancer / Laura D. Locati, Angela Greco, Maria Grazia Borrello, Maria Luisa Carcangiu and Paolo Bossi, et al. -- Targeted Therapies for Non-small-Cell Lung Cancer / Giulio Metro and Lucio Crinò -- Non-Hodgkin's Lymphomas / Roberta Zappasodi and Massimo Di Nicola -- Leukemias / Lia Ginaldi and Massimo De Martinis -- Breast Cancer / Nadia Rucci, Luca Ventura and Anna Teti -- Oesophago-Gastric Cancer / Alex M. Reece-Smith, Simon L. Parsons and Sue A. Watson -- Colorectal Cancer / David N. Church, Rachel Susannah Midgley and David J. Kerr -- Hepatocellular Carcinoma / Yasunori Minami and Masatoshi Kudo -- Biomarkers for Prognosis and Molecularly Targeted Therapy in Renal Cell Carcinoma / Laura S. Schmidt -- Bladder Cancer / Andrea Tubaro, Daniele Santini, Cosimo De Nunzio, Alice Zoccoli and Michele Iuliano -- Biomarkers in Prostate Cancer / Mauro Bologna and Carlo Vicentini -- Ovarian Cancer / Jessica Wangui Oribabor, Allison Ambrosio, Cesar M. Castro and Michael J. Birrer -- Uterine Cancer: The Influence of Genetics and Environment on Cell Cycling Pathways in Cancer / Annekathryn Goodman, Leslie S. Bradford and Leslie A. Garrett -- Biotargets in Sarcomas: The Past, Present, and a Look into the Future / Vivek Subbiah and Razelle Kurzrock -- Melanoma and Other Skin Cancers / Kim H. T. Paraiso, Jobin K. John and Keiran S. M. Smalley -- Molecular Pathology of Cancer Metastasis: Suggestions for Future Therapy / Adriano Angelucci and Edoardo Alesse -- Current and Future Developments in Cancer Therapy Research: miRNAs as New Promising Targets or Tools / Marilena V. Iorio, Patrizia Casalini, Claudia Piovan, Luca Braccioli and Elda Tagliabue.
  • Digital
  • Digital
  • Digital
  • Digital
    Rodney J.Y. Ho, Milo Gibaldi.
    Wiley2013
    Introduction to biopharmaceuticals -- Distinctions of biologic versus small molecule platforms in drug development -- Financing biologic drug development -- Application of biotechnology in drug discovery and early development -- Large-scale production of recombinant proteins -- Clinical pharmacology, toxicology, and therapeutic dosage & response -- Clinical evaluation and regulatory approval & enforcement of biopharmaceuticals -- Pharmacoeconomics and drug pricing / Garrison -- Antibodies and derivatives -- Hematopoietic growth and coagulation factors -- Cytokines and interferons -- Hormones -- Enzymes -- Vaccines / Hu, Ho -- Other biopharmaceutical products -- Advances in personalized medicine : pharmacogenetics in drug therapy -- Gene and cell therapy -- Pharmacoeconomics, outcome, and health technology assessment research in drug development -- Summary and future prospects.
  • Digital
    CRCnetBasev. 29, 2005
  • Digital
    Alfonso Barbarisi (ed.) ; in collaboration with Paolo Bechi, Paolo Innocenti, Carlo Alberto Redi, Francesco Rosso ; foreword by Enrico De Antoni.
    Springer2011
  • Digital
    edited by I.W. Fong and Kenneth Alibek.
    Springer2009
    Anthrax : a disease and a weapon / Kenneth Alibek, Catherine Lobanova and Serguei Popov -- Plague as a biological weapon / David T. Dennis -- Tularemia and bioterrorism / Lisa Hodges and Robert L. Penn -- Melioidosis and Glanders as possible biological weapons / David Allan Brett Dance -- Smallpox as a weapon for bioterrorism / J. Michael Lane -- Hemorrhagic Fever viruses as biological weapons / Allison Groseth ... [et al.] -- Botulism as a potential agent of bioterrorism / Thomas P. Bleck -- Ricin : a possible, noninfectious biological weapon / Maor Maman and Yoav Yehezkelli -- Bioterrorism alert for health care workers / Theodore J. Cieslak, George W. Christopher and Edward M. Eitzen -- The economics of planning and preparing for bioterrorism / Martin I. Meltzer.
  • Digital
    Martin Grassberger, Ronald A. Sherman, Olga S. Gileva, Christopher M.H. Kim, Kosta Y. Mumcuoglu, editors.
    Springer2013
    Biotherapy, an introduction / John C.T. Church -- Maggot therapy / Ronald A. Sherman, Kosta Y. Mumcuoglu, Martin Grassberger and Tarek I. Tantawi -- Hirudotherapy / Olga S. Gileva and Kosta Y. Mumcuoglu -- Apitherapy -- Bee venom therapy / Christopher M.H. Kim -- Apitherapy -- the use of honeybee products / Theodore Cherbuliez -- Ichthyotherapy / Martin Grassberger and Ronald A. Sherman -- Helminth therapy / David E. Elliott, David I. Pritchard, and Joel V. Weinstock -- Phage therapy / Elizabeth M. Kutter, Guram Gvasalia, Zemphira Alavidze and Erin Brewster -- Animal-assisted therapy: benefits and challenges / Mary Cole and Maureen Howard -- Equine-assisted therapy: an overview / Nina Ekholm Fry -- Canine olfactory detection of human disease / Claire Guest.
  • Digital/Print
    edited by Michael L. Johnson, Jo M. Holt and Gary K. Ackers.
    Digital : ScienceDirectpt. A, 2009
    Digital : ScienceDirectpt. B, 2009
    Digital : ScienceDirectpt. C, 2011
    Digital : ScienceDirectpt. D, 2011
  • Digital/Print
    edited by Lester Packer.
    Digital : ScienceDirect1995
    Print1995
  • Digital/Print
    edited by Lester Packer.
    Digital : ScienceDirect1995
    Print1995
  • Digital
    Robert J. Roselli, Kenneth R. Diller.
    Springer2011
    Part I. Fundamentals of How People Learn (HPL) -- Introduction to HPL Methodology -- Part II. Fundamental Concepts in Biotransport -- Fundamental Concepts in Biotransport -- Modeling and Solving Biotransport Problems -- Part III. Biofluid Transport -- Rheology of Biological Fluids -- Macroscopic Approach for Biofluid Transport -- Shell Balance Approach for One Dimensional Biofluid Transport -- General Microscopic Approach for Biofluid Transport -- Part IV. Bioheat Transport -- Heat Transfer Fundamentals -- Macroscopic Approach to Bioheat Transport -- Shell Balance Approach for 1-D Bioheat Transport -- General Microscopic Approach for Bioheat Transport -- Section V. Biological Mass Transport -- Mass Transfer Fundamentals -- Macroscopic Approach to Biomass Transport -- Shell Balance Approach for 1-D Biomass Transport -- General Microscopic Approach for Biomass Transport.
  • Digital
    edited by Carlos A. Zarate, Jr. and Husseini K. Manji.
    Springer2009
  • Digital
    Kostas N. Fountoulakis.
    Springer2015
    This book examines in detail the diagnostic approach to manic depressive (bipolar) illness, with special reference to the borderline zones with unipolar depression and schizoaffective disorder. Among other diagnostic issues considered are mixed episodes (often misdiagnosed by psychiatrists), rapid cycling, and the confusion with personality disorders. Within the context of diagnosis and understanding of the dynamics of bipolar disorder, temperament, character, and personality are all extensively discussed. Neurocognitive deficit and disability are covered, as are elements of evolutionary biology and behavior. With regard to treatment, the major focus is on evidence-based therapy, with reference to the results of randomized controlled trials and meta-analyses; in addition, contemporary guidelines and future trends are examined. Careful consideration is also given to the psychosocial treatment approach and issues relating to societal and economic costs and burdens.
  • Digital
    edited by Jair C. Soares, The University of Texas Health Science Center in Houston, TX, USA, and Allan H. Young, Kings College London, London, UK.
    Cambridge2016
    Over the past two decades, driven by the enormous public health importance of bipolar disorder, research initiatives have begun to elucidate the pathophysiology of this prevalent and debilitating condition. These research initiatives have led to breakthroughs in our understanding of causation, and now promise to foster the development of novel treatments. This new edition presents contributions from the leaders at the forefront of these areas of research, and includes chapters on the groundbreaking advances in the fields of genetics, neuroimaging, neuropsychopharmacology, oxidative stress and neuronal resilience, inflammatory mechanisms, psychosocial factors, childhood onset and late-life bipolar disorder, and many other important areas. Throughout, the therapeutic implications and potential of this new understanding are emphasized. This will be essential reading for those interested in the neurobiology of mental illness, and will be of interest to mental health practitioners more generally. -- Provided by publisher.
  • Digital
    edited by Gordon Parker.
    Cambridge2012
    Introduction to the second edition -- Bipolar disorder in historical perspective / Edward Shorter -- The bipolar spectrum / James Phelps -- Defining and measuring bipolar II disorder / Gordon Parker -- Bipolar II disorder in context : a review of epidemiology, disability and economic burden / George Hadjipavlou, David J. Bond and Lakshmi N. Yatham -- Comorbid conditions associated with bipolar II disorder / Gordon Parker -- Is bipolar II disorder increasing in prevalence? / Gordon Parker and Kathryn Fletcher -- Personality styles associated with bipolar II disorder / Kathryn Fletcher -- Distinguishing bipolar II disorder from personality-based states of emotional dysregulation / Joel Paris -- The neurobiology of bipolar II disorder / Emre Bora and Christos Pantelis -- The role of antidepressants in managing bipolar II disorder / Joseph F. Goldberg -- Current status of mood stabilisers in the management of bipolar II disorder / George Hadjipavlou, David J. Bond and Lakshmi Yatham -- The use of atypical antipsychotic drugs in bipolar II disorder / Eduard Vieta and Nuria Cruz -- The role of fish oil in managing bipolar II disorder / Anne-Marie Rees and Gordon Parker -- Psychological interventions for bipolar II disorder / Vijaya Manicavasagar and David Gilfillan -- The role of wellbeing plans in managing bipolar II disorder / Margo Orum -- The trajectory of illness experienced by those with bipolar II disorder / Tessa Cleradin -- Clinical models for managing bipolar II disorder : model 1 / Gordon Parker -- Clinical models for managing bipolar II disorder : model 2 / Terence A. Ketter and Po W. Wang -- Management commentary / Darryl Bassett -- Management commentary / Michael Berk -- Management commentary / Sophia Frangou -- Management commentary / Mark Frye -- Management commentary / S. Nassir Ghaemi -- Management commentary / Michael Gitlin and David Miklowitz -- Management commentary / Joseph F. Goldberg -- Management commentary / Guy M. Goodwin -- Management commentary / Andrew A. Nierenberg -- Management commentary / Robert M. Post -- Management commentary / Michael E. Thase -- Management commentary / Eduard Vieta -- Management commentary / Allan H. Young -- Rounding up and tying down / Gordon Parker.
  • Digital
    Denys N. Wheatley.
    Springer2012
    Written with disarming honesty by a long-term sufferer of bipolar disorder, with more than half a century's experience of intervention and treatment, this highly personal volume traces the effectiveness of a therapy modality for mental illness that has gained much ground in the past two decades: art. The author began to use art, and in particular doodling, from 1998 as a way of externalizing his feelings. Its expressiveness, accessibility and energy-efficiency was ideally suited to the catatonia he experienced during the bouts of depression that are a feature of bipolar disorder, while as the low moods lifted and his energy surged, he completed more ambitious and elaborate works. As well as being highly eclectic, Wheatley's assembled oeuvre has afforded him both insights and therapeutic intervention into his condition, once deemed highly debilitating and taboo, but much more socially accepted now that well known sufferers such as Stephen Fry have recounted their experiences of the condition. After an opening account of how the images were generated, the volume reproduces a 'gallery' of selected work, and then offers an extended epilogue analyzing the art's connections with the disorder as well as the author's assessment of how each attempt at visual self-expression was, for him, a therapeutic intervention. Wheatley, a cell biologist who has enjoyed a full career in cancer research, has had no formal training in art, yet his haunting pictures, many of them resembling life forms, are brought to life by his perceptive, self-aware commentary. This book will be of interest to psychologists and psychiatrists among the wider medical profession as well as people suffering from any form of bipolar disorder whatever the severity.
  • Digital
    series eds. Axel Schmidt, Stefan H.E. Kaufmann, Manfred H. Wolff.
    Springer2005-16.
    Infectious diseases remain a substantial drain on human well-being and economies despite the availability of modern drugs. New pathogens emerge and known pathogens change their geographical distribution and their susceptibility to the available drugs. An understanding of the structure and function of infectious disease pathogens is a major scientific challenge with important potential applications. This monograph series provides up-to-date information on the latest developments in infectious disease research. The multi-authored volumes cover basic biology and biochemistry of pathogens as well as applied medical aspects and implications for public health and policy.-- Excerpted from publisher notes.
  • Digital
    edited by G. Di Giovanni, V. Di Matteo, E. Esposito.
    Springer2009
  • Print
    Cecilia Van Hollen.
    Status: Not Checked OutLane Catalog Record
    Prologue : into the well and out again -- Birth in the age of AIDS -- India responds to the epidemic -- "The HIV test is like an immunization" : scenes from prenatal HIV counseling -- "I don't need my husband's permission?" : women's views on HIV/AIDS and decisions about prenatal testing -- HIV/AIDS and the gendering of stigma -- To birth or not to birth? : constraints and pragmatics in HIV-positive women's childbearing decisions -- HIV-positive women give birth : deception and determination -- Breast or bottle? : HIV-positive women's responses to global health policy on infant feeding -- Creating a storm : activists' hopes and mothers' fears -- Epilogue : memory boxes.
  • Digital/Print
    [S. J. Ventura].
    Digital1995
    Print1995
  • Digital
    Roland E. Kontermann, editor.
    Springer2011
    "The concept of using bispecific antibodies for cancer therapy by retargeting immune effector cells was developed more than 25 years ago. However, initial clinical studies were rather disappointing mainly due to low efficacy, severe side effects and the immunogenicity of the bispecific antibodies. A deeper understanding of effector cell biology and especially developments in the field of antibody engineering has led to the generation of new classes of bispecific antibodies capable of circumventing many of these obstacles. Furthermore, new applications were established for bispecific antibodies, such as pre-targeting strategies in radioimmunotherapy and dual targeting approaches in order to improve binding, selectivity and efficacy. In this book, the different means of generating bispecific antibodies are described, with an emphasis on recombinant formats, and information on the various applications of bispecific antibodies, e.g. in cellular cancer immunotherapy, radioimmunotherapy and pretargeting strategies, but also on emerging applications such as dual targeting strategies, i.e., the simultaneous inhibition of two targets (cytokines, receptors, etc.) are provided. This book is intended for a broad readership in the field of antibody engineering, mainly from the pharmaceutical and biotechnology sector, but also including academic researchers working in this field."--Publisher's website.
  • Digital
    Francesco Saverio De Ponte, editor ; foreword by Giorgio Iannetti.
    Springer2012
    1. Introduction / Robert E. Marx -- 2. Pharmacology: Mechanism of Action of Bisphosphonates / Angelina De Sarro and Letteria Minutoli -- 3. Use of Bisphosphonates in Oncology / Giuseppe Altavilla, Grazia Marabello, Chiara Tomasello and Vincenzo Pitini -- 4. Use of Bisphosphonates in Hematology / Caterina Musolino and Alessandro Allegra -- 5. Use of Bisphosphonates in Osteoporosis / Angelina De Sarro and Letteria Minutoli -- 6. Biomorphology in BIONJ: Anatomy and Histology / Giuseppina Cutroneo -- 7. Etiopathogenesis and Clinical Aspects of BIONJ / Santino Ferrara, Laura Vuolo, Annamaria Colao and Luigi Califano -- 8. Instrumental Diagnosis / Silvio Mazziotti, Achille Mileto, Michele Gaeta, Giorgio Ascenti, Ignazio Salamone, Carmela Visalli and Alfredo Blandino -- 9. Microbiological Aspects of Osteonecrosis of the Jaw / Stefania Leuci, Marco Friscia and Michele Davide Mignogna -- 10. Prevention and the Role of the Dentist / Giacomo Oteri -- 11. Conservative Treatment: Oxygen-Ozone Therapy / Alessandro Agrillo -- 12. Conservative Treatment: LASER (Biostimulation and Minimally Invasive Surgical Treatment) / Paolo Vescovi -- 13. Minimally Invasive Surgical Treatment / Claudio Marchetti, Gian Andrea Pelliccioni, Filippo Moretti, Francesco Saverio De Ponte, Giuseppe Lombardo and Carla Nava -- 14. Major Surgery in BIONJ / Luciano Catalfamo, Carla Nava, Giuseppe Lombardo and Francesco Saverio De Ponte -- 15. BRONJ: The Future / Salvatore L. Ruggiero.
  • Print
    Damon Tweedy, M.D.
    Status: Not Checked OutLane Catalog Record
    When Tweedy began medical school, he envisioned a bright future where his segregated, working-class background would become irrelevant. Instead he found himself grappling with race, bias, and the unique health problems of black Americans, and met a professor who bluntly questioned whether he belonged in medical school. In examining the complex ways in which both black doctors and patients must navigate the difficult and often contradictory terrain of race and medicine, he illustrates the complex social, cultural, and economic factors at the root of most health problems in the black community.
  • Digital
    edited by Cheryl T. Lee and David P. Wood.
    Springer2010
  • Digital
    Alan J. Wein, Karl-Erik Andersson, Marcus J. Drake, Roger R. Dmochowski, editors.
    Springer2014
    Bladder Dysfunction in the Adult: The Basis for Clinical Management succinctly describes all that the healthcare professional needs to know when treating lower urinary tract symptoms. The book describes how to assess and treat every group of patients likely to be affected with bladder problems, and the underlying mechanisms responsible. Women with stress incontinence, men with enlarged prostates, people with neurological disease and the elderly are all discussed in particular detail. For all professionals treating or learning to treat patients with urinary storage or voiding problems, the concise presentation and thorough coverage provides treatment recommendations and clear explanations. Authored by recognized experts in their respective fields, Bladder Dysfunction in the Adult: The Basis for Clinical Management is a comprehensive resource that allows the reader to develop the knowledge, understanding, and confidence to deal with the many clinical challenges of bladder dysfunction.
  • Digital
    Jørgen Nordling, Jean-Jacques Wyndaele, Joop P. van de Merwe, Pierre Bouchelouche, Mauro Cervigni, Magnus Fall, editors.
    Springer2013
    Historical Perspective / Philip M. Hanno M.D., M.P.H. -- Epidemiology / Mirja Ruutu M.D., Ph.D., F.E.B.U., Mikael Leppilahti MD, PhD -- Diagnostic Criteria, Classification and Nomenclature for Bladder Pain Syndrome / Joop P. van de Merwe MD, PhD, Jørgen Nordling MD, Dr.med.Sci, FEBU -- Part I: Pathophysiology -- Clinical Pathophysiology and Molecular Biology of the Urothelium and the GAG Layer / Gianfranco Tajana, Mauro Cervigni -- Mast Cell and Bladder Pain Syndrome / Kirsten Bouchelouche M.D., D.M.Sc., Pierre Bouchelouche M.D. -- Neurophysiology of Pelvic Pain Mechanisms / Jean-Jacques Wyndaele M.D., D.Sci., Ph.D., Silvia Malaguti M.D. -- Syndromes Associated with Bladder Pain Syndrome as Clues to its Pathogenesis / John W. Warren M.D., Joop P. van de Merwe M.D., Ph.D. -- Part II: Clinical Presentations -- Bladder Pain Syndrome: Clinical Presentation / John Hughes M.B.B.S., F.R.C.A., F.F.P.M.R.C.A. -- Pelvic Floor Dysfunction in Bladder Pain Syndrome / Mauro Cervigni M.D., Franca Natale M.D. -- Psychosocial Risk Factors and Patient Outcomes for Bladder Pain Syndrome / Dean A. Tripp Ph.D., J. Curtis Nickel M.D., F.R.C.S.C. -- Bladder Pain Syndrome and Sexuality / Jennifer Yonaitis Fariello M.S.N., C.R.N.P., Kristene E. Whitmore M.D. -- Part III: Diagnosis -- Symptoms of Bladder Pain Syndrome / John W. Warren M.D., Philip M. Hanno M.D., M.P.H. -- Clinical Evaluation and Diagnosis of Bladder Pain Syndrome / Jennifer Yonaitis Fariello M.S.N., C.R.N.P., Kristene E. Whitmore M.D. -- Urine Biomarkers and Bladder Pain Syndrome / Pierre Bouchelouche M.D., Kirsten Bouchelouche M.D., DMSc. -- Cystoscopy and Hydrodistension in the Diagnosis of Bladder Pain Syndrome / Andrey Zaytsev M.D., Ph.D., Magnus Fall M.D., Ph.D. -- Biopsy Retrieval, Tissue Handling, Morphology, and Histopathological Characteristics / Christina Kåbjörn-Gustafsson, Ralph Peeker -- Urodynamics in BPS / Paul P. Irwin M.Ch., F.R.C.S.I(Urol), Claus Riedl M.D. -- Complementary and Alternative Medical Treatments of Bladder Pain Syndrome / Z. Chad Baxter M.D., Helen R. Levey D.O., M.P.H. -- Diet and Its Role in Bladder Pain Syndrome and Comorbid Conditions / Justin I. Friedlander, Barbara Shorter, Robert M. Moldwin -- Physiotherapy / Amy Rejba Hoffmann M.S.N., Hina M. Sheth M.S., P.T., O.C.S., M.T.C. -- Oral Therapy for Bladder Pain Syndrome Directed at the Bladder / Philip M. Hanno M.D., M.P.H. -- Pain Treatment in Bladder Pain Syndrome / John Hughes M.B.B.S., F.R.C.A., F.F.P.M.R.C.A., Salma Mohammed M.B.B.S., F.R.C.A. -- Intravesical Therapy / Mauro Cervigni M.D., Arndt van Ophoven M.D., Ph.D. -- Hydrodistention, Transurethral Resection and Other Ablative Techniques in the Treatment of Bladder Pain Syndrome / Magnus Fall M.D., Ph.D., Jørgen Nordling M.D., Dr. Med. Sci., F.E.B.U., Ralph Peeker -- Botulinum Toxin Treatment in Bladder Pain Syndrome / Paul P. Irwin M.Ch., F.R.C.S.I. (Urol), Paulo Dinis Oliveria M.D., Ph.D. -- Neurostimulation for Bladder Pain Syndrome / Dominique El-Khawand M.D., Kristene E. Whitmore -- Bladder Augmentation, Urinary Diversion and Cystectomy in Patients with Bladder Pain Syndrome / Jørgen Nordling, Magnus Fall, Ralph Peeker -- Part V: Patient Perspective -- A Patient Perspective / Jane M. Meijlink BA Hons -- Exploratory Research on the Social Costs and Care for Patients with Bladder Pain Syndrome / Loredana Nasta, Simone Montagnoli, Maria Avolio.
  • Digital
    Vinata B. Lokeshwar, Axel S. Merseburger, Stefan H. Hautmann, editors.
    Springer2011
  • Digital
    Ignacio Blanco.
    ScienceDirect2017
    Alpha-1 antitrypsin deficiency -- Serpins and serpinopathies -- Alpha-1 antitrypsin biology -- Alpha-1 antitrypsin gene, genetic heritage, phenotypes, and genotypes -- Alpha-1 antitrypsin deficiency -- Alpha-1 antitrypsin deficiency -- Genetic epidemiology -- Laboratory diagnosis -- Clinical diagnosis -- Liver disease associated with Alpha-1 antitrypsin deficiency -- Respiratory manifestations of the Alpha-1 antitrypsin deficiency -- Other diseases associated with Alpha-1 antitrypsin deficiency -- Clinical management and treatment of lung disease -- Registries and patients' associations -- Current research and future perspectives.
  • Digital
    Anthony M.J. Bull, Jon Clasper, Peter F. Mahoney, editors.
    Springer2016
    Part 1. Basic Science and Engineering -- 1. The fundamentals of blast physics -- 2. Biomechanics in blast -- 3. Behaviour of materials -- 4. Blast Loading of Cells -- 5. Biological Tissue Response -- Part 2. Weapon Effects and the Human -- 6. Blast Injury Mechanism -- Section 3. Principles of Investigating and Modelling Blast and Blast Mitigation -- 7. The examination of post-blast scenes -- 8. Clinical Forensic Investigation of the 2005 London Suicide Bombings -- 9. Modelling the blast environment and relating this to clinical injury- Experience from the 7/7 Inquest -- 10. The mortality review panel: a report on the deaths on operations of UK Service personnel 2002-2013 -- 11. Physical Models- Tissue Simulants.-12. Physical Models- Organ models for primary blast -- 13. In Vivo Models of blast injury -- 14. Modelling Blast brain injury -- 15. Military wound ballistics base study: Development of a Skull/Brain Model -- 16. Surrogates of human injury -- 17. Computational methods in continuum mechanics -- 18. Energised fragments: bullets and fragment simulating projectiles -- Part 4. Applications of blast injury research: Solving clinical problems -- 19. Coagulopathy and inflammation: an overview of blast effects -- 20. Foot and Ankle Blast Injuries -- 21. Traumatic Amputation -- 22. Testing and development of mitigation systems for tertiary blast -- 23. Pelvic blast injury -- 24. Behind Armour blunt trauma (BABT) -- 25. Blast Injury to the Spine -- 26. Primary Blast Lung Injury -- 27. Regional effec ts of explosive devices: The neck -- 28. Optimising the anatomical coverage provided by military body Armour systems -- 29. Blast injuries of the Eye -- 30. Hearing damage through blast -- 31. Peripheral Nerve Injuries.
  • Digital
    Heinz Mehlhorn, Kevin S.W. Tan, Hisao Yoshikawa, editors.
    Springer2012
    The stages of blastocystis have been known for 101 years. However, many facts are still disputed, e.g. even the question whether it is a true pathogen or a commensal present in sometimes life-threatening diarrheas.The present book evaluates in chapters contributed by renowned researchers the latest findings on: landmarks in the discovery of blastocystis; epidemiology, transmission and zoonotic potential; morphology of human and animal blastocystis isolates; clinical aspects of blastocystis infections; behavioral decision analysis: what makes us sick?; blastocystis-host interactions; molecular approaches on the systematical position; genetic polymorphism; blastocystis from a statistical point of view; diarrheas due to different agents of disease; zoonotic diseases in comparison. As such, this book provides a broad range of information for people working in this field, for physicians and veterinarians who are confronted with clinical cases, teachers, students and technical staff members in the fields of microbiology, parasitology and diagnostic methods -- P. [4] of cover.
  • Digital/Print
    Robert J. Kurman, Lora Hedrick Ellenson, and Brigitte M. Ronnett (eds.).
    Digital : Springer2011
    Print2011
  • Digital
    Eyal Sheiner, editor.
    Springer2011
    Clinical Approach to Pregnancy-Related Bleeding -- Early Pregnancy Loss -- Ectopic Pregnancy -- Vaginal Bleeding and Gestational Trophoblastic Disease -- Gynecological Cancer During Pregnancy -- Vaginal Bleeding and Preterm Delivery -- Placental Abruption -- Placenta Previa and Placenta Accreta -- Vasa Previa -- Uterine Rupture -- Postpartum Hemorrhage -- Coagulopathy and Pregnancy -- Anesthesia and Intensive Care Management of Bleeding During Pregnancy.
  • Digital
    Blessed, G.; Stern, Y.
  • Digital
    Blessed, G.; Stern, Y.
  • Digital
    Dédée F. Murrell, editor.
    Springer2015
  • Print
    edited by Manfred Horstmanshoff, Helen King, and Claus Zittel.
    Physiologia from Galen to Jacob Bording / Vivian Nutton -- Physiological analogies and metaphors in explanations of the Earth and the cosmos / Liba Taub -- The reception of the Hippocratic treatise On glands / Elizabeth Craik -- Between atoms and humours. Lucretius' didactic poetry as a model of integrated and bifocal physiology / Fabio Tutrone -- Losing ground. The disappearance of attraction from the kidneys / Michael R. McVaugh -- The art of the distillation of 'spirits' as a technological model for human physiology. The cases of Marsilio Ficino, Joseph Duchesne and Francis Bacon / Sergius Kodera -- The body is a battlefield. Conflict and control in seventeenth-century physiology and political thought / Sabine Kalff -- Herman Boerhaave's neurology and the unchanging nature of physiology / Rina Knoeff -- The anatomy and physiology of mind. David Hume's vitalistic account / Tamás Demeter -- More than a fading flame. The physiology of old age between speculative analogy and experimental method / Daniel Schäfer -- Suffering bodies, sensible artists. Vitalist medicine and the visualising of corporeal life in Diderot / Tomas Macsotay -- Blood, clotting and the four humours / Hans L. Haak -- An issue of blood. The healing of the woman with the haemorrhage (Mark 5.24b-34; Luke 8.42b-48; Matthew 9.19-22) in early medieval visual culture / Barbara Baert, Liesbet Kusters and Emma Sidgwick -- The nature of the soul and the passage of blood through the lungs. Galen, Ibn al-Nafis, Servetus, İtaki, ʹAṭṭār / Rainer Brömer -- Sperm and blood, form and food. Late medieval medical notions of male and female in the embryology of Membra / Karine van 't Land -- The music of the pulse in Marsilio Ficino's Timaeus commentary / Jacomien Prins -- 'For the life of a creature is in the blood' (Leviticus 17:11). Some considerations on blood as the source of life in sixteenth-century religion and medicine and their interconnections / Catrien Santing -- White blood and red milk. Analogical reasoning in medical practice and experimental physiology (1560-1730) / Barbara Orland -- The "Body without Skin" in the Homeric poems / Valeria Gavrylenko -- Sweat. Learned concepts and popular perceptions, 1500-1800 / Michael Stolberg -- Of the fisherman's net and skin pores. Reframing conceptions of the skin in medicine 1572-1714 / Mieneke te Hennepe -- Vision and vision disorders. Galen's physiology of sight / Véronique Boudon-Millot -- Early modern medical thinking on vision and the camera obscura. V.F. Plempius' Ophthalmographia / Katrien Vanagt -- The Tertium comparationis of the Elementa physiologiae. Johann Gottfried von Herder's conception of "Tears" as mediators between the sublime and the actual bodily physiology / Frank W. Stahnisch -- From doubt to certainty. Aspects of the conceptualisation and interpretation of Galen's natural pneuma / Julius Rocca -- Metabolisms of the soul. The physiology of Bernardino Telesio in Oliva Sabuco's Nueva filosofía de la naturaleza del hombre (1587) / Marlen Bidwell-Steiner -- "Ful of Rapture". Maternal vocality and melancholy in Webster's Duchess of Malfi / Marion A. Wells -- The sleeping musician. Aristotle's vegetative soul and Ralph Cudworth's plastic nature / Diana Stanciu.
  • Digital
    [edited by] Anna Porwit, Jeffrey McCullough, Wendy N. Erber.
    ScienceDirect2011
    ClinicalKey2011
    1. Normal blood cells -- 2. Normal bone marrow cells: development and cythology -- 3. Normal bone marrow histology -- 4. Regulation of hematopoiesis -- 5. Pathology of the marrow: general considerations and infections/reactive conditions -- 6. Investigation and classification of anemia -- 7. Abnormalities of the red cell membrane -- 8. Erythroenzyme disorders -- 9. Abnormalities of the structure and synthesis of hemoglobin -- 10. Acquired hemolytic anemia -- 11. Iron deficiency anemia, anemia with chronic disorders and iron overload -- 12. Macrocytic anemia -- 13. Aplastic anemia and pure red cell aplasia -- 14. Sideroblastic anemia -- 15. Congenital dyserythropoietic anemias -- 16. Abnormalities in leukocyte morphology and number -- 17. Disorders of phagocyte function -- 18. Acute myeloid leukemias -- 19. Acute lymphoblastic leukemia/lymphoma and mixed phenotype acute leukemias -- 20. Myelodysplastic syndromes -- 21. Molecular studies in myeloproliferative and myelodysplastic/myeloproliferative neoplasms -- 22. Erythrocytosis and polycythemia -- 23. Essential thrombocythemia and primary myelofibrosis -- 24. Chronic myelogenous leukemia -- 25. Myeloproliferative neoplasms and eosinophilia -- 26. Systemic mastocytosis -- 27. Myelodysplastic/myeloproliferative neoplasms -- 28. The chronic lymphoid leukemias -- 29. Lymphoma -- 30. Abnormalities in immunoglobulin synthesizing cells -- 31. Hemostasis : principles of investigation -- 32. Disorders affecting megakaryocytes and platelets : inherited conditions -- 33. Acquired disorders affecting megakaryocytes and platelets -- 34. Inherited disorders of coagulation -- 35. Acquired bleeding disorders -- 36. Natural anticoagulants and thrombophilia -- 37. Blood groups on red cells, platelets and neutrophils -- 38. Transfusion medicine for pathologists -- 39. Histocompatibility : HLA and other systems.
  • Digital
    Richard T. Maziarz, Susan Slater.
    Springer2011
    Overview of hematopoietic stem cell transplantation -- The business of cellular therapy and hematopoietic stem cell transplantation -- Stem cell sources -- Pre-transplant evaluation -- Conditioning regimens -- Supportive care -- Nutrition -- Infection prophylaxis -- Graft-versus-host disease prophylaxis -- Transfusion medicine -- Antithrombotic guidelines -- Engraftment -- Follow-up care -- Infectious complications -- Acute graft-versus-host disease -- Chronic graft-versus-host disease -- Oral complications -- Gastrointestinal complications -- Pulmonary complications -- Cardiovascular complications -- Acute kidney injury -- Thrombotic microangiopathies -- Graft failure -- Post-transplant relapse -- Palliative care -- Survivorship.
  • Digital
    Richard T. Maziarz, Susan Schubach Slater, editors.
    Springer2015
  • Digital
    edited by Bipin N. Savani.
    Wiley2014
    Introduction / Bipin N. Savani -- Overview : transplant data and increasing numbers of long-term survivors / Jakob R. Passweg and Helen Baldomero -- Long-term transplant clinic setup / Andre Tichelli ... [et al.] -- Late effects after allogeneic hematopoietic stem cell transplantation / Sairah Ahmed and Yago Nieto -- Late effects after autologous hematopoietic stem cell transplantation / Sairah Ahmed and Yago Nieto -- Graft-versus-host disease and late effects after hematopoetic stem cell transplantation / Gerard Socie -- Prominent role of allied health professionals (nurse practitioners, physician assistants, others) in long term follow-up after hematopoietic stem cell transplantation / Catherine E. Lucid -- Screening and prevention guidelines for hematopoietic cell transplant survivors / Navneet S. Majhail and j. Douglas Rizzo -- Secondary malignancies : prevalence, screening, prevention, and management guidelines / Paolo F. Caimi and Hillard M. Lazarus -- Cutaneous chronic graft-versus-host disease / Attilio Olivieri ... [et al.] -- Anti-infective prophylaxis, immunization and prevention of recurrent infectious complications in long-term survivors / John P. Galvin and Jayesh Mehta -- Seasonal virus infections : prevention and management guidelines / Gaurav Trikha and John R. Wingard -- Exposure to family members : infections and recent live vaccinations / Brian G. Engelhardt and James E. Crowe, Jr. -- Late pulmonary complications after allogeneic hematopietic stem cell transplantation : bronchiolitis obliterans syndrome (BOS) and organizing pneumonia (OP) / Lee Gazourian ... [et al.] -- Post-transplantation bone disease : prevalence, monitoring, prevention and management guidelines / Andre Tichelli and Alicia Rovo -- Ocular complications : prevalence, monitoring, prevention, and management guidelines / Andre Tichelli and Alicia Rovo -- Oral complications in hematopoietic stem cell transplantation survivors : monitoring and management / Andrea L. Utz and Shubhada Jagasia -- Fertility issues, contraception, and pregnancy outcome in long-term survivors / Alicia Rovo ... [et al.] -- Follow-up of children after hematopoietic stem cell transplantation : growth and development / Kristina K. Hardy ... [et al.] -- Posttransplant diabetes mellitus : monitoring, prevention, and management guidelines / Prathima Jasti, Shichun Bao, and Shubhada Jagasia -- Thyroid disease : monitoring and mangement guidelines / M. Kathleen Figaro ... [et al.] -- Special issues related to female long-term survivors / Melissa A. Merideth ... [et al.] -- Cardiac and vascular complications in long-term survivors after hematopoietic stem cell transplantation / Alicia Rovo and Andre Tichelli -- Hyperlipidemia : prevalence, monitoring, management, interactions with immunosuppressive agents and follow-up / Dara L. Eckerle Mize, Shubhada Jagasia, and Jeffrey B. Boord -- Hypertension management in long-term survivors / Imad Abboud -- Gastrointestinal complications of hematopoietic cell transplantation / Preet Bagi ... [et al.] -- Hepatic complications of hematopoietic stem cell transplantation / Niharika Samala ... [et al.] -- Monitoring and management of hepatitis B, hepatitis C, and HIV infection before and after transplantation / Keith Luckett and Stephen Dummer -- Prevention and management of renal complications in long-term survivors / Michael Dickenmann and Joerg P. Halter -- Immunosuppressive agents and monitoring in long-term survivors / Paul Shaughnessy and Helen Leather -- Nutritional assessments and nutritional supplementation for long-term transplant survivors : multivitamins, vitamin D, Calcium, antioxidants, and minerals / Lauren Zatarain ... [et al.] -- Daily routines and guidelines : driving, infection isolation, masks, food/diet, activities, exercise, pets, sun exposures, and others / Angela M. Woods -- Caregivers of long-term survivors / Elizabeth Wulff-Burchfield -- Health-related quality of life in adult and pediatric survivors of hematopoietic stem cell transplantation / Margaret Bevans and Lori Wiener -- Prevalent psychosocial adjustment issues nd solutions : lifestyle and social challenges / Katrina M. Stokes -- Patient's perspective : concepts of long-term survivor support groups and their roles / Michael W. Brown -- Appendix 1 NMDP/Be the match posttransplant guidelines resources / Darlene Haven -- Appendix 2 Long-term follow-up calendar / Andre Tichelli ... [et al.] -- Appendix 3 Commonly used transplant-related medications in long-term survivors / Melissa Logue.
  • Print
    Tibor J. Greenwalt, Edwin A. Steane, section editors.
    Status: Not Checked OutLane Catalog Record
  • Digital
    edited by Sukriti Nag.
    Springer Protocols2011
    Morphology and properties of brain endothelial cells -- Morphology and properties of pericytes -- Morphology and properties of astrocytes -- The blood-cerebrospinal fluid barrier: Structure and functional significance -- The blood-retinal barrier: Structure and functional significance -- The blood-nerve barrier: Structure and functional significance -- Detection of multiple proteins in intracerebral vessels by confocal microscopy -- Multiparametric magnetic resonance imaging and repeated measurements of blood-brain barrier permeability to contrast agents -- Detection of brain pathology by magnetic resonance imaging of iron oxide micro-particles -- Measuring the integrity of the human blood-brain barrier using magnetic resonance imaging -- Assessing blood-cerebrospinal fluid barrier permeability in the rat embryo -- Detection of blood-nerve barrier permeability by magnetic resonance imaging -- Isolation of human brain endothelial cells and characterization of lipid raft-associated proteins by mass spectroscopy -- Analysis of mouse brain microvascular endothelium using laser capture microdissection coupled with proteomics -- Molecular and functional characterization of P-glycoprotein in vitro -- Methods to study glycoproteins at the blood-brain barrier using mass spectrometry -- Novel models for studying the blood-brain and blood-eye barriers in drosophila -- Zebrafish model of the blood-brain barrier: Morphological and permeability studies -- Methods to assess pericyte-endothelial cell interactions in a coculture model -- Isolation and properties of an in vitro human outer blood-retinal barrier model -- Isolation and properties of endothelial cells forming the blood-nerve barrier -- Treatment of focal brain ischemia with viral vector-mediated gene transfer -- Blood-brain barrier disruption in the treatment of brain tumors -- Integrated platform for brain imaging and drug delivery across the blood-brain barrier -- Targeting the choroid plexus-CSF-brain nexus using peptides identified by phage display.
  • Print
    edited by Ruth Lyck, Gaby Enzmann.
    Status: Not Checked OutLane Catalog Record
    Within the central nervous system (CNS) the constantly changing blood stream is separated from the CNS parenchyma by the blood brain barrier (BBB) restricting passage to selected immune cells. Under pathological conditions, however, viruses, bacteria, parasites and autoaggressive immune cells can penetrate the barrier and contribute to CNS inflammation. The BBB actively contributes to neuroinflammation by presentation of chemokines, expression of cell adhesion molecules and alteration of barrier properties. As such, understanding the role of the BBB under healthy and pathological conditions is essential for the development of new drugs to efficiently combat inflammatory diseases of the CNS. This book presents a comprehensive collection of reviews that focus on the role of the BBB. Experts in the field share their insight on structural, topological and functional properties of the BBB. They elaborate on pathophysiological changes of the inflamed BBB such as permeability, transporter proteins and alterations in microRNAs and cytokine profile. Additional chapters on multiple sclerosis and bacterial meningitis provide in depth information on significant neuroinflammatory diseases. The selection is complemented by a review on the current understanding of the BBB as signaling hub in tumor pathogenesis in the brain.
  • Print
    edited by Lodovico Balducci, William Ershler, Giovanni de Gaetano.
    Status: Not Checked OutLane Catalog Record
  • Digital
  • Digital
    Abraham Noordergraaf.
    Springer2011
    pt. 1. Synoptic reviews of thinking in circulatory physiology -- pt. 2. Circulatory sub-systems -- pt. 3. Impedance defined flow and the closed loop.
  • Digital
    Michel E. Safar, Michael F. O'Rourke, Edward D. Frohlich, editors.
    Springer2014
    Part I. Blood Pressure: Basic Concepts of Steady and Pulsatile Arterial Hemodynamics -- 1. Arterial Stiffness, Wave Reflection, Wave Amplification: Basic Concepts, Principles of Measurement and Analysis in Humans / Michael F. O'Rourke, Caroline O'Brien, and Thomas Weber -- 2. Large Arteries, Microcirculation, and Mechanisms of Hypertension / Harry A.J. Struijker-Boudier -- 3. Direct Measurement of Local Arterial Stiffness and Pulse Pressure / Luc M. Van Bortel, Tine De Backer, and Patrick Segers --4. Ventricular-Arterial Coupling and Mechanism of Wave Reflections / Julio A. Chirinos and Patrick Segers -- 5. Determination of Systemic and Regional Arterial Structure and Function / Pierre Boutouyrie, Laurent Macron, Elie Mousseaux, and Stéphane Laurent -- 6. Animal Models for Studies of Arterial Stiffness / Patrick Lacolley, Simon N. Thornton, and Yvonnick Bezie -- 7. Elastin, Calcium and Age-Related Stiffening of the Arterial Wall / Jeffrey Atkinson -- 8. Genetic and Cellular Aspects of Arterial Stiffness / Athanase Benetos, Abraham Aviv, Patrick Lacolley, Michel E. Safar, and Véronique Regnault -- Part II. Blood Pressure and Sodium Balance: Pathophysiological Mechanisms and Cardiovascular Risk -- 9. Mechanical Stress and the Arterial Wall / Ernesto L. Schiffrin, Alain Tedgui, and Stephanie Lehoux -- 10. Pulsatile Stress, Arterial Stiffness, and Endothelial Function / Robinson Joannidès, Jérémy Bellien, and Christian Thuillez -- 11. Hypoxia, Arterial Blood Pressure, and Microcirculation / Jean-Jacques Mourad, Jean-Sébastien Silvestre, and Bernard I. Lévy -- 12. The Reality of Aging Viewed from the Arterial Wall / Majd AlGhatrif and Edward G. Lakatta -- 13. Emerging Aspects of Angiotensin Biology and Their Potential Role in the Vasculature / Richard N. Re and Julia L. Cook -- 14. Arterial Stiffness and the Sympathetic Nervous System / Gianfranco Parati and Paolo Salvi -- 15. Oxidative Stress and Hypertension / Jing Wu and David G. Harrison -- 16. Heart Failure with Preserved Ejection Fraction / Scott L. Hummel -- 17. Structural Alterations in Arterial Stiffness: Role of Arterial Fibrosis / Javier Díez -- 18. Salt and Multiorgan Damage in Hypertension: Vascular Stiffening and Cardiorenal Structural Dysfunction Responses / Edward D. Frohlich -- 19. Preventive Lessons from Hypertension and Myocardial Infarction: Treating Asymptomatic Individuals to Lower the Risk for Subsequent Cardiovascular Events / Marc A. Pfeffer -- Part III. Hypertension: Evaluation of Cardiovascular Risk and Organ Damage -- 20. Value of Brachial and Central Blood Pressure for Predicting Cardiovascular Events / Stanley S. Franklin, Carmel M. McEniery, John R. Cockcroft, and Ian B. Wilkinson -- 21. Predictive Value of Arterial Stiffness for Cardiovascular Events / Stéphane Laurent, Pierre Boutouyrie, and Francesco Mattace Raso -- 22. Heart Rate, Synchrony and Arterial Hemodynamics / Alberto P. Avolio, Mark Butlin, and Isabella Tan -- 23. Pulse Pressure Amplification and Arterial Stiffness in Middle Age / Alberto P. Avolio, Mark Butlin, and Athanase D. Protogerou -- 24. Arterial Stiffness, Central Blood Pressure and Cardiac Remodelling: From Cardiac Hypertrophy to Heart Failure / Mary J. Roman and Richard B. Devereux -- 25. The Relationship Between Aortic Stiffness, Microvascular Disease in the Brain and Cognitive Decline: Insights into the Emerging Epidemic of Alzheimer's Disease / Angelo Scuteri, Jonathan Stone, and Michael F. O'Rourke -- 26. Arterial Stiffness and Risk in Various Cardiovascular Diseases / Charalambos Vlachopoulos, Dimitrios Terentes- Printzios, Kenji Takazawa, and Christodoulos Stefanadis -- 27. Large Artery Remodeling and Chronic Kidney Disease / Marie Briet, Michel Delahousse, Gérard London, Stéphane Laurent, and Pierre Boutouyrie -- 28. Arterial Changes in Renal Transplantation / Sola Aoun Bahous, Serge Korjian, Yazan Daaboul, Jacques Blacher, and Michel E. Safar -- 29. Arterial Stiffness, Central Blood Pressure and Coronary Heart Disease / Piotr Jankowski, Jacques Blacher, and Thomas Weber -- Part IV. Clinical Involvement: Role of Age, Sex, Inflammatory and Metabolic Alterations -- 30. Modifications of Blood Pressure Profiles in the Very Old: Role of Frailty and Comorbidities / Athanase Benetos, Sylvie Gautier, and Michel E. Safar -- 31. Arterial Stiffness and Amplification in the Very Old / Athanase Benetos, Ghassan Watfa, Paolo Salvi, and Patrick Lacolley -- 32. Hypertension in Men and Women: Is It Different? / Harold Smulyan and Bruno Pannier -- 33. Obesity, Metabolic Syndrome, Diabetes and Smoking / Isabel Ferreira, Roel J.J. van de Laar, and Coen D.A. Stehouwer -- 34. Glucose, Insulin and Potential Strategies of Vascular Stiffening / Guanghong Jia, Annayya R. Aroor, Gerald A. Meininger, and James R. Sowers -- 35. Arterial Stiffness in Chronic Inflammation / Kaisa M. Mäki-Petäjä, Carmel M. McEniery, Stanley S. Franklin, and Ian B. Wilkinson -- Part V. Stratifications of Cardiovascular Risk and Therapeutic Consequences on Arterial Stiffness and Wave Reflections -- 36. Outcome-Driven Thresholds for Pulse Pressure on Office and Out-of-the-Office Blood Pressure Measurement / Yumei Gu, Lucas S. Aparicio, Yanping Liu, Kei Asayama, Tine W. Hansen, Teemu J. Niiranen, José Boggia, Lutgarde Thijs, and Jan A. Staessen -- 37. Properties of Central Arteries in Populations of Different Ethnicity: Ethnicity and Central Arteries / Augustine Nonso Odili, Yumei Gu, and Jan A. Staessen -- 38. Changing Concepts on the Role of Blood Pressure Reduction in Stroke Prevention with the Focus on β-Blocking Agents / Ji-Guang Wang, Feng-Hua Ding, Li-Hua Li, and Yan Li -- 39. Decreasing Arterial Stiffness and/or Wave Reflections Independently of Mean Arterial Pressure: Effect of Antihypertensive Drugs (Part 1) / Hélène Beaussier, Stéphane Laurent, and Pierre Boutouyrie -- 40. Decreasing Arterial Stiffness and/or Wave Reflections Independently of Mean Arterial Pressure: Effect of Non-antihypertensive Drugs (Part 2) / Hélène Beaussier, Stéphane Laurent, and Pierre Boutouyrie -- 41. Blood Pressure Variability: Measurements, Influential Factors, Prognosis and Therapy / Yi Zhang, Davide Agnoletti, Alexandra Yannoutsos, Michel E. Safar, and Jacques Blacher -- 42. Nitrate: The Ideal Drug Action for Isolated Systolic Hypertension in Elderly? / Xiong J. Jiang and Michael F. O'Rourke -- 43. De-stiffening Strategy, Sodium Balance, and Blockade of the Renin-Angiotensin System / Athanase D. Protogerou, Michel E. Safar, Gerard E. Plante, and Jacques Blacher -- 44. Long-Term Effects of Calcium Channel Blockers on Central and Peripheral Arteries / Yoshio Matsui and Michael F. O'Rourke -- 45. Exercise Training for the Modification of Arterial Stiffness and Wave Reflections / Julian W. Sacre and Bronwyn A. Kingwell.
  • Digital
    William B. White, editor.
    Springer2016
  • Print
    by Åke Rieger and Sten-Otto Liljedahl.
    -- Changes in blood volume and plasma proteins after bleeding and immediate substitution with physiologic saline, dog plasma and dog albumin in the splenectomized dog / Å. Rieger -- 3. Changes in blood volume and plasma proteins after bleeding and immediate substitution with Macrodex. Rheomacrodex and Physiogel in the splenectomized dog / Å. Rieger -- 4. Importance of thoracic duct lymph in restitution of plasma volume and plasma proteins after bleeding and immediate substitution in the splenectomized dog / S -- O. Liljedahl and Å. Rieger.
  • Print
    American Heart Association ; editor, Mary Fran Hazinski ; senior managing editor, S. Lynn Hunter-Wilson ; special contributors, Janet Butler [and others] ; BLS Subcommittee 2010-2011, Robert A. Berg [and others].
    Status: Not Checked OutLane Catalog Record
    General concepts -- BLS/CPR basics for adults -- Automated external defibrillator for adults and children 8 years of age and older -- BLS/CPR for children from 1 year of age to puberty -- BLS/CPR for infants -- Automated external defibrillator for infants and for children from 1 to 8 years of age -- CPR with an advanced airway -- Mouth-to-mouth breaths -- Rescue breathing -- Relief of choking -- Appendix -- Recommended reading.
  • Digital
    Peter J. Hotez, MD, PhD, Baylor College of Medicine.
    ProQuest Ebook Central2016Limited to 3 simultaneous users
    In 2011, Dr. Peter J. Hotez relocated to Houston to launch Baylor's National School of Tropical Medicine. He was shocked to discover that a number of neglected diseases often associated with developing countries were widespread in impoverished Texas communities. Despite the United States' economic prowess and first-world status, an estimated 12 million Americans living at the poverty level currently suffer from at least one neglected tropical disease, or NTD. Hotez concluded that the world's neglected diseases-which include tuberculosis, hookworm infection, lymphatic filariasis, Chagas disease, and leishmaniasis-are born first and foremost of extreme poverty. In this book, Hotez describes a new global paradigm known as "blue marble health," through which he asserts that poor people living in wealthy countries account for most of the world's poverty-related illness. By crafting public policy and relying on global partnerships to control or eliminate some of the world's worst poverty-related illnesses, Hotez believes, it is possible to eliminate life-threatening disease while at the same time creating unprecedented opportunities for science and diplomacy.
  • Digital
    Laura M. Segal, Anne De Biasi, Dara Alpert Lieberman, Genny Olson, Vinu Ilakkuvan.
    All Americans should have the opportunity to be as healthy as they can be. Every community should be safe from threats to its health. All individuals and families should have a high level of services that protect, promote and preserve their health, regardless of who they are or where they live. To realize these goals, the incoming Administration and Congress should make improving health a top priority. There is nothing more valuable to the nation than the health and vitality of the American people. Experts have identified top strategies and approaches for ways the public health and health systems can work better -- which is important, but far from sufficient. Where we live, learn, work and play can have a bigger impact on health than medical care alone. Working together, the public health, healthcare and social service systems can achieve a much stronger collective impact. Moving forward, we must build partnerships and leverage assets across the health system, mental and behavioral health systems, social and public services, the private sector and communities to work together toward the common aim of a Healthier America.
  • Print
    Frank W. Drislane ... [et al.].
    Status: Not Checked OutLane Catalog Record
    The neurologic examination -- Neurologic investigations -- The approach to coma and altered consciousness -- Neuro-ophthalmology -- The approach to weakness -- The sensory system -- Dizziness, vertigo, and syncope -- Ataxia and gait disorders -- Urinary and sexual dysfunction -- Headache and facial pain -- Aphasia and other disorders of higher cortical function -- Dementia -- Sleep disorders -- Vascular disease -- Seizures -- Movement disorders -- Head trauma -- Systemic and metabolic disorders -- Central nervous system tumors -- Demyelinating diseases of the central nervous system -- Infections of the nervous system -- Disorders of the spinal cord -- The peripheral nervous system -- Disorders of the neuromuscular junction and skeletal muscle -- Pediatric neurology.
  • Print
    Tamara Callahan, Aaron B. Caughey.
    Status: Not Checked OutLane Catalog Record
  • Print
    Bradley S. Marino, Katie S. Fine.
    Status: Not Checked OutLane Catalog Record
    Emergency management : evaluation of the critically ill or injured child -- Poisoning, burns, and injury prevention -- Cardiology -- Development -- Dermatology -- Endocrinology -- Fluid, electrolyte, and pH management -- Gastroenterology -- Genetic disorders -- Hematology -- Immunology, allergy, and rheumatology -- Infectious disease -- Neonatology -- Nephrology and urology -- Neurology -- Nutrition -- Oncology -- Ophthalmology -- Orthopedics -- Pulmonology -- Adolescent medicine.
  • Print
    Michael J. Murphy, Ronald L. Cowan ; faculty advisor, Lloyd I. Sederer.
    Status: Not Checked OutLane Catalog Record
    Psychotic disorders -- Mood disorders -- Anxiety disorders -- Personality disorders -- Substance-related disorders -- Eating disorders -- Disorders of childhood and adolescence -- Cognitive disorders -- Miscellaneous disorders -- Special clinical settings -- Antipsychotics -- Antidepressants and somatic therapies -- Mood stabilizers -- Anxiolytics -- Miscellaneous medications -- Major adverse drug reactions -- Psychological theory and psychotherapy -- Legal issues.
  • Print
    Seth J. Karp, James P.G. Morris ; questions and answers provided by Stanley Zaslau.
    Status: Not Checked OutLane Catalog Record
  • Digital
    editor-in-chief, William R. Jarnagin ; associate editors, Jacques Belghiti ... [et al.] ; editor emeritus, Leslie H. Blumgart.
    ScienceDirect2012
    Comprehensive and complete, Blumgart's Surgery of the Liver, Pancreas and Biliary Tract - edited by Dr. William R. Jarnagin and a team of experts- delivers the comprehensive, cutting-edge guidance you need to achieve optimal outcomes in surgery of the liver, biliary tract, and pancreas. Edited by a panel of experts and featuring contributions by many leading authorities, this 2-volume reference brings you the latest information on pathology, diagnostics, surgery, and non-operative intervention all in one source. At www.expertconsult.com you can not only access the complete contents online, but also an abundance of detailed illustrations and step-by-step procedural video clips from the Memorial Sloan Kettering video library that show you how to perform key procedures step by step. Glean all essential, up-to-date, need-to-know information in one comprehensive reference that provides extensive coverage of pathology, diagnostics, surgery, and non-operative intervention as well as hepatobiliary and pancreatic surgery. Deepen your understanding of surgical anatomy to help with diagnosis, surgical operation, interventional radiology, and endoscopy.
  • Digital
    editor-in-chief, William R. Jarnigan ; associate editors, Peter J. Allen, William C. Chapman, Michael I. D'Angelica, Ronald P. DeMatteo, Richard Kinh Gian Do, Jean-Nicolas Vauthey ; editor emeritus, Leslie H. Blumgart.
    ScienceDirect2017
    ClinicalKey2017
  • Digital
    Michael P. Cancro, editor.
    Springer2010
  • Digital
    edited by Reinhold Munker, Gerhard C. Hildebrandt, Hillard M Lazarus, Kerry Atkinson.
    Cambridge2013
    Machine generated contents note: Preface; Part I. Basic Science: 1. Hematopoietic cell transplantation: past, present and future Reinhold Munker; 2. Basic science Reinhold Munker and Kerry Atkinson; Part II. Hematologic Malignancies: 3. Therapeutic decision making in BMT/SCT for acute myeloid leukemia Reinhold Munker, Gerhard C. Hildebrandt and Kerry Atkinson; 4. Therapeutic decision making in BMT/SCT for acute lymphoblastic leukemia Reinhold Munker, Vishwas Sakhalkar, Hillard M. Lazarus and Kerry Atkinson; 5. Therapeutic decision making in BMT/SCT for chronic myeloid leukemia and other myeloproliferative syndromes Reinhold Munker, Hillard M. Lazarus and Kerry Atkinson; 6. Therapeutic decision making in BMT/SCT for chronic lymphatic leukemia Nebu Verghese Koshy, Reinhold Munker, Hillard M. Lazarus and Kerry Atkinson; 7. Therapeutic decision making in BMT/SCT for myelodysplasia Carolina Escobar, Reinhold Munker and Kerry Atkinson; 8. Hematopoietic cell transplantation for non-Hodgkin lymphoma Saurabh Chhabra and Ginna G. Laport; 9. Therapeutic decision making in BMT/SCT for Hodgkin lymphoma Reinhold Munker, Hillard M. Lazarus and Kerry Atkinson; 10. Therapeutic decision making in hematopoietic stem cell transplantation for multiple myeloma Reinhold Munker, Oscar F. Ballester, Hillard M. Lazarus and Kerry Atkinson; 11. Therapeutic decision making in SCT for amyloidosis Reinhold Munker, Hillard M. Lazarus and Kerry Atkinson; Part III. Solid Tumors: 12. Therapeutic decision making in BMT/SCT for nonseminomatous germ cell tumor of testis (NSGCT) Reinhold Munker, Hillard M. Lazarus and Kerry Atkinson; 13. Therapeutic decision making in BMT/SCT for renal cell cancer Richard Childs and Reinhold Munker; 14. Therapeutic decision making in BMT/SCT for soft tissue sarcomas Reinhold Munker, Vishwas Sakhalkar, Hillard M. Lazarus and Kerry Atkinson; Part IV. Nonmalignant Disorders: 15. Therapeutic decision making in BMT/SCT for severe aplastic anemia Reinhold Munker, Anna Locasciulli and Kerry Atkinson; 16. Therapeutic decision making in BMT/SCT for congenital immunodeficiencies Vishwas Sakhalkar, Reinhold Munker and Kerry Atkinson; 17. Therapeutic decision making in BMT/SCT for hemoglobinopathies Shalini Shenoy, Reinhold Munker and Kerry Atkinson; 18. Hematopoietic stem cell transplantation for inborn errors of metabolism and neurodegenerative disorders Robert F. Wynn, Jaap J. Boelens and Muhammad A. Saif; 19. Therapeutic decision making in BMT/SCT for autoimmune disorders Reinhold Munker; 20. Cellular therapy Hans-Jochem Kolb, Kerry Atkinson and Reinhold Munker; Part V. Practical Aspects and Procedures: 21. Practical aspects and procedures, including conditioning protocols and haploidentical transplantation Reinhold Munker, Hillard M. Lazarus and Kerry Atkinson; 22. Umbilical cord blood as alternative allogeneic graft source: clinical banking and transplant outcomes Mary J. Laughlin and Reinhold Munker; Part VI. Complications: 23. Pathobiology of graft-versus-host disease Pavan Reddy; 24. Diagnosis and treatment of graft-versus-host-disease Daniel R. Couriel; 25. Management and prophylaxis of infections after BMT/SCT Nicholas Barber and Alison G. Freifeld; 26. Organ-related and miscellaneous complications Gerhard C. Hildebrandt, Reinhold Munker, Ullrich Duffner, Daniel Wolff, Michael Stadler, Tina Dietrich, Klemens Angstwurm, Amanda Sun, Binu Nair, Hillard M. Lazarus and Kerry Atkinson; Part VII. The BMT/SCT Pharmacopoeia: 27. The BMT/SCT pharmacopoeia Jill Comeau, Reinhold Munker and Kerry Atkinson; Part VIII. HLA-Testing and Laboratory Medicine: 28. HLA-testing and laboratory medicine Nicholas R. DiPaola, Reinhold Munker and Kerry Atkinson; Appendix: guide to the internet and literature databases relevant for bone marrow and stem cell transplantation; Index.
  • Digital
    Gregory Schwaid.
    ScienceDirect2017
    Board Review in Preventive Medicine and Public Health prepares physicians for their initial and recertification board exams in the related specialties of preventive, occupational and aerospace medicine. Formatted in a question and answer based style that imitates material on specialty exams, each question is linked to a detailed answer. The book contains over 640 question and answer sets covering areas such as general public health, health management, health law, community health, infectious disease, clinical preventive medicine, occupational medicine, aerospace medicine, environmental medicine, correctional (prison) medicine, emergency preparedness, epidemiology and biostatistics. The book is an essential board preparation for physicians with a background in the fields of preventive medicine, occupational medicine, and aerospace medicine. It is also useful for medical students, public health students and those wishing to gain an understanding of the key points in these fields.
  • Digital
    Rachel Prentice.
    ProQuest Ebook Central2013Limited to 1 simultaneous users
    In Bodies in Formation, anthropologist Rachel Prentice enters surgical suites increasingly packed with new medical technologies to explore how surgeons are made in the early twenty-first century.
  • Digital
    Jianqing Wang, Qiong Wang.
    Wiley2013
    Introduction to Body Area Communications -- Electromagnetic Characteristics of the Human Body -- Electromagnetic Analysis Methods -- Body Area Channel Modeling -- Modulation/Demodulation -- Body Area Communication Performance -- Electromagnetic Compatibility Considerations -- Summary and Future Challenges.
  • Digital
    edited by Henry C. Lukaski.
    TandFonline2017
    Body composition in perspective / Henry Lukaski -- Assessment of human body composition : methods and limitations / Hannes Gatterer, Kai Schenk, and Martin Burtscher -- Assessment of muscle mass / Donald Dengel, Christiana J Raymond, and Tyler Bosch -- Hydration status and performance / Ronald Maughan and Susan Shirreffs -- Physical activity on growth and development of youth / Robert Malina and Manuel J. Coelho e Silva -- Anthropometry in physical performance and health / Arthur Stewart and Tim Ackland -- Physical activity and adipose tissue redistribution in obese adults / Brittany P. Hammond, Andrea M. Brennan, and Robert Ross -- Physical activity and body composition changes in overweight and obese children / Scott Going, Jennifer Bea, and Joshua Farr -- Body composition changes with training : methodological implications / Luis Sardinha and Diana Santos -- Endurance athletes / Jordan Moon and Kristina Kendall -- Speed, power and strength athletes / David David Fukuda, Jeffery Stout, and Jay Hoffman -- Weight-sensitive sports / Analiza Silva, Diana Santos, and Catarina Matias -- Military / Karl Friedl -- Body composition and public safety : the industrial athlete / Paul Davis and Mark Abel -- Dietary protein and physical training effects on body composition and physical performance / Michaela C Devries, Sara Y Oikawa, and Stuart Phillips -- Supplements, body composition and performance / Karl Friedl -- Diet and exercise approaches for reversal of exercise-associated amenorrhea / Lynn Cialdella Kam and Melinda Manore.
  • Digital
    volume editors, C.V. Mobbs, P.R. Hof.
    Karger2010
    Contribution of adipose tissue to health span and longevity / Huffman, D.M., Barzilai, N. -- Obesity paradox during aging / Chapman, I.M. -- Central control of food intake in aging / Kmiec, Z. -- Changes in food intake and its relationship to weight loss during advanced age / McDonald, R.B., Ruhe, R.C. -- Changes in body composition in response to challenges during aging in rats / Wolden-Hanson, T. -- New haystacks reveal new needles : using Caenorhabditis elegans to identify novel targets for ameliorating body composition changes during human aging / Wolkow, C.A. -- Sarcopenia : prevalence, mechanisms, and functional consequences / Berger, M.J., Doherty, T.J. -- mTOR signaling as a target of amino acid treatment of the age-related sarcopenia / D'Antona, G., Nisoli, E. -- Mitochondrial theory of aging in human age-related sarcopenia / Parise, G., De Lisio, M. -- Exercise as a calorie restriction mimetic : implications for improving healthy aging and longevity / Huffman, D.M. -- Clinical, cellular and molecular phenotypes of aging bone / Syed, F.A. ... [et al.].
  • Digital
    J. Peter Rubin [and others].
    ClinicalKey2013
    Introduction: Body contouring surgery - a fifty year perspective -- Patient safety in body contouring -- Liposuction of the upper extremities -- Brachioplasty with bicipital groove scar -- Brachioplasty - the double ellipse technique -- Brachioplasty with liposuction resection -- Limited scar brachioplasty -- Fat grafting to the breast -- Ultrasound-assisted breast reduction -- Combined abdominal contouring and mastopexy -- Breast reshaping using autologous tissues after massive weight loss -- Combined abdominoplasty and breast enlargement by autologous tissue transfer or transabdominal implant placement -- Mammaplasty with L-shaped scar -- Breast reshaping after massive weight loss: Autologous tissue techniques -- Breast reshaping after massive weight loss, implant based -- Liposuction of upper back/bra rolls -- Transverse upper body lift -- Upper body lift with lateral excision -- Aesthetic classification of the abdomen -- Anatomy of the abdominal wall and aesthetic classification -- Lipomyosculpture -- Classic abdominoplasty with adhesion tension sutures -- Lipoabdominoplasty with previous flap resection -- Reverse abdominoplasty -- Endoscopic plication techniques for the treatment of abdominal contour -- High lateral tension abdominoplasty -- Fleur-de-lis abdominoplasty including mons contouring -- Panniculectomy in patients with super obesity -- Lipoabdominoplasty -- Umbilicoplasty -- Combining abdominal contouring with hernia repair -- Liposuction of the abdomen and trunk -- Belt lipectomy/circumferential abdominoplasty -- Progressive tension sutures in abdominoplasty -- Transverse medial thigh lift -- Vertical medial thigh lift with liposuction -- Short vertical scar medial thigh lift -- Autologous gluteal augmentation with mid-pedicle superior pole perforator flaps -- Liposuction and circumferential lower truncal dermatolipectomy -- Gluteal contouring and rejuvenation -- Buttock implants -- Buttock contouring with liposuction and fat injection -- Liposuction of the lower extremities and leg reshaping with fat -- Calf and thigh implants -- Lipoplasty - history and principles -- Tumescent local anesthesia for liposuction -- Treatment of liposuction complications -- Fat grafting in body contouring surgery -- Minimal scar breast augmentation using autologous fat grafting -- Principles of new invasive modalities -- Ultrasonic liposuction -- High intensity focused ultrasound and non-invasive body contouring -- Mesotherapy for body contouring and cellulite -- Describing the deformities -- Psychological and nutritional evaluation -- Staging and combining procedures.
  • Digital
    [edited by] David L. Coy, Eugene Lin, Jeffrey P. Kanne.
    McGraw-Hill eBook Library2015
    The physics of computed tomography -- CT radiation dose and management -- Contrast administration -- Mediastinum -- Lung -- Airways -- Pleura, diaphragm, and chest wall -- Heart and thoracic aorta -- Liver and biliary -- Pancreas -- Kidneys, ureters, and bladder -- Adrenal glands -- Spleen -- Gastrointestinal tract -- Peritoneum and peritoneal spaces -- Retroperitoneum, vessels, and nodes -- Pelvis -- Trauma.
  • Digital
    edited by Katharine A. Phillips.
    Oxford Medicine Online2017
  • Digital
    Felice Eugenio Agrò, editor.
    Springer2013
    The administration of intravenous fluids is one of the most common and important therapeutic practices in the treatment of surgical, medical and critically ill patients. The international literature accordingly contains a vast number of works on fluid management, yet there is still confusion as to the best options in the various situations encountered in clinical practice.The purpose of this volume is to help the decision-making process by comparing different solution properties describing their indications, mechanisms of action and side-effects according to physiologic body water distribution, electrolytic and acid-base balance, and to clarify which products available on the market represent the best choice in different circumstances. The book opens by discussing in detail the concepts central to a sound understanding of abnormalities in fluid and electrolyte homeostasis and the effect of intravenous fluid administration. In the second part of the monograph, these concepts are used to explain the advantages and disadvantages of solutions available on the market in different clinical settings. Body Fluid Management: From Physiology to Therapy will serve as an invaluable decision-making guide, including for those who are not experts in the subject.
  • Print
    John Robb, University of Cambridge, Oliver J.T. Harris, University of Cambridge.
    Status: Not Checked OutLane Catalog Record
    This book is a long-term history of how the human body has been understood in Europe from the Palaeolithic to the present day, focusing on specific moments of change. Developing a multi-scalar approach to the past, and drawing on the work of an interdisciplinary team of experts, the authors examine how the body has been treated in life, art and death for the last 40,000 years. Key case-study chapters examine Palaeolithic, Neolithic, Bronze Age, Classical, Medieval, Early Modern and Modern bodies. What emerges is not merely a history of different understandings of the body, but a history of the different human bodies that have existed. Furthermore, the book argues, these bodies are not merely the product of historical circumstance, but are themselves key elements in shaping the changes that have swept across Europe since the arrival of modern humans.
  • Digital/Print
    Mieczyslaw Pokorski, editor.
    Digital : Springer2015
    Print2015
    The dynamics of body metabolism are changed in the disease process and interact with physical activity. The alteration of metabolism and its consequences raise the need for simple and reliable methods for assessment of body composition. The chapters aim to investigate various interacting components converging on metabolic changes in lung and muscle tissues taking into consideration the drug effects. The effects of exercise and nutritional status are dealt with at a great extent.
  • Digital
    Jeonhee Jang.
    TandFonline2015
    Body reshaping for health and beauty -- A first look at the meridian system in TCM -- Who can benefit from this treatment? -- Body posture and homeostasis -- Six body types -- Anatomical approach type M1, M2, M3 -- Muscle meridian therapy and skin cutaneous therapy -- Treatment methods -- Specific clinical cautions and application.
  • Digital
    edited by Jeffery S. Orringer, Jeffrey S. Dover, Murad Alam.
    ClinicalKey2016
    Improve your technique, treat patients with confidence, and obtain optimal results using today's most advanced body shaping treatments with guidance from Body Shaping: Skin, Fat and Cellulite, a volume in the Procedures in Cosmetic Dermatology Series. Renowned cosmetic dermatologists-Drs. Orringer, Alam, and Dover-provide you with procedural how-to's and step-by-step advice on proper techniques, pitfalls, and tricks of the trade, equipping you to successfully incorporate the very latest for skin tightening, fat reduction, and sculpting procedures into your busy practice!
  • Digital
    Scott H. Faro, Feroze B. Mohamed, editors.
    Springer2010
    Principles of functional MRI -- fMRI scanning methodologies -- Experimental design and data analysis for fMRI -- Challenges in fMRI and its limitations -- Clinical challenges of fMRI -- Brain mapping for neurosurgery and cognitive neuroscience -- fMRI of memory in aging and dementia -- fMRI of language systems: methods and applications -- fMRI Wada test: prospects for presurgical mapping of language and memory -- Cognitive neuroscience applications -- Neuroanatomical atlas.
  • Digital
    Felix Bronner, Mary C. Farach-Carson, (eds.).
    Springer2009
  • Digital
    Felix Bronner, Mary C. Farach-Carson, and Helmtrud I. Roach (eds.).
    Springer2010
    Genetic and epigenetic aspects of bone development -- Tissue interactions in long bone development -- The epiphyseal growth plate -- Hedgehog signaling in growth plate and bone development -- Role of microRNA in skeleton development -- FGF/FGFR signaling in skeletal dysplasias -- The role of hypoxia-induced factors -- BMP signaling in skeletogenesis -- Wnt signaling in bone development -- Development of the craniofacial complex -- Dentin and bone: similar collagenous mineralized tissues -- Evolution of bone proteins -- Osteogenesis imperfect -- Fibrodysplasia ossificans progressive: developmental implications of a novel metamorphogene -- Bone-mineral homeostasis and associated pathologies -- Interrelationship between bone and other tissues: brain-bone axis and bone-adipo axis -- Mechanobiology of bone development and computational simulations.
  • Digital
    edited by Werner Zimmerli.
    Wiley2015
    Microbiology of bone and joint infections -- Pharmacokinetics and pharmacodynamics of antibiotics in bone -- Preclinical models of infection in bone and joint surgery -- Native joint arthritis in children -- Native joint arthritis -- Septic arthritis of axial joints -- Periprosthetic joint infection : general aspects -- Periprosthetic joint infection after total hip and knee arthroplasty -- Periprosthetic joint infection after shoulder arthroplasty -- Periprosthetic joint infection after elbow arthroplasty -- Periprosthetic joint infection after ankle arthroplasty -- Osteomyelitis : classification -- Osteomyelitis in children -- Acute osteomyelitis in adults -- Subacute osteomyelitis : tuberculous and brucellar vertebral osteomyelitis -- Chronic osteomyelitis in adults -- Diabetic foot osteomyelitis -- Osteomyelitis of the jaws -- Implant-associated osteomyelitis of long bones -- Implant-associated vertebral osteomyelitis -- Postoperative sternum osteomyelitis.
  • Digital
    edited by Hans-Jörg Oestern, Otmar Trentz, Selman Uranues.
    Springer2014
    All European countries, including those that have recently joined the European Union or are candidates for membership, currently show a clear trend towards an increasing number of accidental injuries. This holds true for a range of injuries, including accidents among the elderly, sports injuries, and trauma due to traffic accidents. The increase in the number of injuries is accompanied by rising expectations among patients, who anticipate good functional results even after serious injuries. Despite these developments, trauma surgery is not yet established as an independent field in all European countries. Against this background, there is a clear need for a book that covers the state of the art in trauma surgery. This volume, which focuses on bone and joint injuries orthopedic trauma is intended to help to meet this need. It will also serve to harmonize the practice of trauma surgery within the European Union and to prepare for the UEMS EBSQ trauma surgery.
  • Print
    by Leonard W. Ely and John Francis Cowan.
  • Digital
    edited by Andrew L. Folpe, Carrie Y. Inwards.
    ClinicalKey2010
    Bone and Soft Tissue Pathology: A Volume in the Diagnostic Pathology Series, by Andrew L. Folpe, MD and Carrie Y. Inwards, MD, packs today's most essential bone and soft tissue pathology know-how into a compact, high-yield format! The book's pragmatic, well-organized approach, complemented by abundant full-color, high-quality illustrations and at-a-glance tables, makes it easy to access the information you need to quickly and accurately identify pathology specimens. Best of all, Expert Consult functionality provides online access to the full text of the book, downloadable illustrations for your personal use, and more. The result is a practical, affordable reference for study and review as well as for everyday clinical practice. Includes access to the complete contents online, fully searchable, downloadable illustrations for your personal use, and more, allowing you to consult the text a quick, convenient manner. Reviews normal histology before examining abnormal findings, enabling you to conveniently compare their characteristics in one place at one time. Covers both neoplastic and non-neoplastic conditions of bone and soft tissue to equip you to meet a wide range of diagnostic challenges. Uses a consistent, user-friendly format to explore each entity's clinical features, pathologic features (gross and microscopic), ancillary studies, differential diagnoses, and prognostic and therapeutic considerations ... making it easy to locate specific information on a particular entity. Features abundant boxes and tables throughout that enhance the presentation and accessibility of the material. Offers nearly 1,000 full-color, high-quality illustrations that demonstrate the key features of a wide variety of pathologic lesions to facilitate greater accuracy in identification of specimens.
  • Digital
    [editor], Andrew E. Horvai ; radiology editor, Thomas Link.
    ClinicalKey2012
    "Save time identifying and diagnosing pathology specimens with High Yield Bone and Soft Tissue Pathology, edited by Drs. Andrew Horvai and Thomas Link. Part of the High-Yield Pathology Series, this title is designed to help you review the key pathologic features of bone and soft-tissue malformations, recognize the classic look of each disease, and quickly confirm your diagnosis. Its templated format, excellent color photographs, concise bulleted text, and authoritative content will help you accurately identify more than 160 discrete disease entities. Online access to complete text, image bank, and more at www.expertconsult.com makes this an ideal reference for on-the-go pathologists."--Publisher's website.
  • Digital
    [edited by] Dominique Heymann.
    ClinicalKey2015
    Epidemiology of primary bone tumors and economical aspects of bone metastases -- Tumor: bone interactions: there is no place like bone -- Stem cell niches in the bone: bone marrow organ and their significance for hematopoietic and non-hematopoietic cancer -- Deregulation of osteoblast differentiation in primary bone cancers -- Contribution of osteoclasts to the bone: tumor niche -- Involvement of osteocytes in cancer bone niche -- Role of mesenchymal stem cells in bone cancer; initiation, propagation and metastasis -- Gap junction in bone remodeling and in primary bone tumors: osteosarcoma and Ewing sarcoma -- Macrophages and pathophysiology of bone cancers -- Cytokines and bone cancers -- Technical aspects: how do we best prepare bone samples for proper histological analysis? -- Bone remodeling markers and bone cancer -- Cancer stem cells in representative bone tumors: osteosarcoma, Ewing sarcoma and metastases from breast and prostate carcinomas -- Homeobox genes from the Dlx family and bone cancers -- MicroRNA implication in therapeutic resistance and metastatic dissemination of bone-associated tumors -- Hypoxia and angiogenesis: from primary tumor to bone metastasis -- Modeling osteosarcoma: in vitro and in vivo approaches -- Stemness markers of osteosarcoma -- Molecular pathology of osteosarcoma -- Gene and proteomic profiling of osteosarcoma -- Ewing sarcoma family of tumors -- Biology of Ewing sarcoma -- Osteoclast-rich lesions of bone: a clinical and molecular overview -- Markers for bone sarcomas -- Margins and bone tumors: what are we talking about? -- Cytogenetics of bone tumors -- Genetic aspects of bone tumors -- Cytogenetic and molecular genetic alterations in bone tumors -- Genetics of giant cell tumors of bone -- Mammalian models of bone sarcomas -- Zebrafish models for studying bone cancers: mutants, transgenic fish and embryos -- Imaging of bone sarcomas -- New therapeutic targets in Ewing sarcoma: from pre-clinical proof-of-concept to clinical trials -- Therapeutic approaches for bone sarcomas -- Chondrosarcoma of bone: diagnosis and therapy -- Apoptosis and drug resistance in malignant bone tumors -- Giant cell tumors of bone -- EMT process in bone metastasis -- Histopathology of skeletal metastases -- Disseminated tumor cells in bone marrow of cancer patients -- MicroRNA-mediated regulation of bone metastasis formation: from primary tumors to skeleton -- Myeloma and osteoclast relationship -- In vivo models used in studies of bone metastases -- Interventional radiologic techniques in management of bone tumors -- Diagnosis of bone metastases in urological malignancies : an update -- Pre-clinical molecular imaging of "the seed and the soil" in bone metastasis -- Mechanisms and management of bone cancer pain -- Bone cancer: current opinion in palliative care -- Involvement of sympathetic nerves in bone metastasis -- Pain control with palliative radiotherapy in patients with bone metastases -- Cellular and molecular actions of bisphosphonates -- The use of nitrogen-bisphosphonates to capture the potent anti-tumor arsenal of human peripheral blood [gamma delta] T cells for the treatment of bone cancer metastasis -- Systemic treatment of bone metastases in castration-resistant prostate cancer (CRPC): pre-clinical to clinical point of view -- A multi-targeted approach to treating bone metastases -- Bone metastases in prostate cancer: pathophysiology, clinical complications, actual treatment, and future directions -- Bone-targeted agents and skeletal-related events in breast cancer patients with bone metastases -- Bone metastases : current status of bone-targeted treatments -- Bone metastases, clinical trials II: zoledronic acid and denosumab in the prevention of bone metastases.
  • Digital
    edited by Dominique Heymann.
    ScienceDirect2010
    Chapter 1. Epidemiology of Primary Bone Tumors and Economical Aspects of Bone Metastases / Esther I. Hauben, Pancras C.W. Hogendoorn -- Chapter 2. Tumor-Bone Cell Interactions in Bone Metastases / Pierrick G.J. Fournier, Lauren K. Dunn, Gregory A. Clines, Theresa A. Guise -- Chapter 3. Early Bone Metastasis-Associated Molecular and Cellular Events / Philippe Clézardin -- Chapter 4. Regulation of Osteoblast Differentiation and Bone Cancers by Wnt and PTH Signaling Pathways / Julia Billiard, John A. Robinson, Ramesh A. Bhat, Bheem M. Bhat, Richard J. Murrills, Peter V.N. Bodine -- Chapter 5. Osteoclast Differentiation and Function / Luis Filgueira -- Chapter 6. Immunoregulation of Osteoclast Differentiation in Multiple Myeloma Bone Disease / Maria Grano, Giacomina Brunetti, Silvia Colucci -- Chapter 7. Facts and Hypothesis on Osteolytic Lesions Related to Normal and Tumoral Epithelial Dental Cell Differentiation / Blandine Ruhin, Frédéric Lézot, Aymann Bouattour, Sonia Ghoul-Mazgar, Ariane Berdal, Vianney Descroix -- Chapter 8. The Role of the Interleukin-6 Family of Cytokines in Bone Remodeling and Bone Cancer / Frédéric Blanchard, Emmanuelle David, Bénédicte Brounais -- Chapter 9. Proteases and Therapeutic Approaches of Bone Tumors / Velasco C. Ruiz, Y. Fortun, D. Heymann, M. Padrines -- Chapter 10. Bone Remodeling Markers and Bone Cancer / Markus J. Seibel -- Chapter 11. Cytogenetic and Molecular Genetic Alterations in Bone Tumors / Suvi Savola, Tom Böhling, Sakari Knuutila -- Chapter 12. Cytogenetics of Bone Tumors / Jiyun Lee, Mallory Martin, Shibo Li -- Chapter 13. Genetic Aspects of Bone Tumors / Shamini Selvarajah, Maria Zielenska, Jeremy A. Squire, Paul C. Park -- Chapter 14. Proteomics of Bone Cancer / Stephanie Byrum, Eric R. Siegel, Sudeepa Bhattacharyya, Larry J. Suva -- Chapter 15. Genomic and Proteomic Profiling of Osteosarcoma / Tsz-Kwong Man, Pulivarthi H. Rao, Ching C. Lau -- Chapter 16. Molecular Pathology of Osteosarcoma / Walter C. Bell, Gene P. Siegal -- Chapter 17. Technical Aspects: How Do We Best Prepare Bone Samples for Proper Histological Analysis? / Daniel Chappard -- Chapter 18. Osteoclast-rich Lesions of Bone: A Clinical and Molecular Overview / Adrienne M. Flanagan, Roberto Tirabosco, Panagiotis D. Gikas -- Chapter 19. Recent Advances in the Biology of Bone Tumors and New Diagnostic Tools / Gonzague de Pinieux, Corinne Bouvier -- Chapter 20. Ewing's Sarcoma Family of Tumors / Joseph D. Khoury -- Chapter 21. The Histopathology of Skeletal Metastases / Ping Tang, David G. Hicks -- Chapter 22. Interventional Radiologic Techniques and their Contribution to the Management of Bone Tumors / Robert G. Jones, Eric J. Heffernan, Faisal Rashid, Peter L. Munk -- Chapter 23. Imaging of Bone Metastases / Nieroshan Rajarubendra, Nathan Lawrentschuk -- Chapter 24. Diagnosis of Skeletal Metastases in Malignant Extraskeletal Cancers / Holger Schirrmeister, Coskun Arslandemir -- Chapter 25. Pain Control with Palliative Radiotherapy in Bone Metastases / Alysa Fairchild, Amanda Hird, Edward Chow -- Chapter 26. Mechanisms and Management of Bone Cancer Pain / Ma'ann C. Sabino, Denis R. Clohisy -- Chapter 27. Malignant Skeletal Pain: Mechanisms and Potential Therapeutic Opportunities / Monica Herrera, Juan Miguel Jimenez-Andrade, Marina Vardanyan, Patrick W. Mantyh -- Chapter 28. Animal Models of Malignant Primary Bone Tumors and Novel Therapeutic Approaches / Julie Rousseau, François Lamoureux, Gaëlle Picarda, François Gouin, Valérie Trichet, Françoise Rédini -- Chapter 29. In vivo Models Used in Studies of Bone Metastases / Ingunn Holen, Michelle A. Lawson -- Chapter 30. Cytokine Gene Therapy in Bone Remodeling / Carl D. Richards, David Smyth -- Chapter 31. Non-surgical Treatment of Chondrosarcoma: Current Concepts and Future Perspectives / Eric L. Staals, Emanuela Palmerini, Stefano Ferrari, Mario Mercuri -- Chapter 32. Mechanistic Role of RANKL in Cancer-induced Bone Diseases and Development of a Targeted Therapy to Inhibit this Pathway / William C. Dougall -- Chapter 33. Chondrosarcoma of Bone: Diagnosis and Therapy / Arne Streitbuerger, Jendrik Hardes, Georg Gosheger -- Chapter 34. Current Status of Immunotherapy for Osteosarcoma and its Future Trends / Kanji Mori, Kosei Ando, Yoshitaka Matsusue, Dominique Heymann -- Chapter 35. Bisphosphonates, Bone Health and the Clinical Biology of Bone Metastases from Breast Cancer / Alexander H.G.Paterson -- Chapter 36. A Multi-targeted Approach to Treating Bone Metastases / Robert D. Loberg, Kenneth J. Pienta -- Chapter 37. Bone Metastases of Prostatic Cancer: Pathophysiology, Clinical Complications, Actual Treatment and Future Directions / Sara De Dosso, Fernanda G. Herrera, Dominik R. Berthold -- Chapter 38. Apoptosis and Drug Resistance in Malignant Bone Tumors / Udo Kontny.
  • Digital
    Sydney Lou Bonnick, Lori Ann Lewis.
    Springer2013
    An introduction to conventions in densitometry -- Densitometry techniques -- Skeletal anatomy in densitometry -- Performing a DXA PA lumbar spine, proximal femur, or forearm DXA study -- Radiation safety in x-ray densitometry -- Quality control procedures -- The importance of precision -- Using absolute risk to predict fracture risk in clinical practice -- An overview of osteoporosis -- Interpretation of bone densitometry data -- Less than perfect scan images -- Pediatric densitometry -- VFA imaging, femoral morphometry, and hip structural analysis -- Body composition analysis.
  • Digital
    Sydney Lou Bonnick ; foreword by Paul D. Miller.
    Springer2010
    Densitometry techniques -- Skeletal anatomy in densitometry -- Statistical overview for the non-statistician densitometrist -- Quality control -- Radiation safety in x-ray densitometry -- Bone density data among technologies and manufacturers -- Selecting patients for bone mass measurements : clinical guidelines -- Selecting patients for bone mass measurements : self-assessment indices -- Diagnosing ostoporosis -- Predicting fracture risk -- Monitoring changes in bone density -- Secondary causes of osteoporosis -- New applications for DXA -- Reporting densitometry --FDA-approved densitometry devices..
  • Print
    by Harold G. Jacobson. Assisted by Robert H. Freiberger, [et. al.]
    Status: Not Checked OutLane Catalog Record
  • Digital
    Reiner Bartl, Christoph Bartl ; with a contribution by Andrea Baur-Melnyk and Tobias Geith.
    Springer2017
  • Digital
    Gordon L. Klein, editor.
    Springer2014
  • Digital
    Ellen B. Fung, Laura K. Bachrach, Aenor J. Sawyer, editors.
    Springer2016
    1. Rationale for bone health assessment in childhood and adolescence -- 2. Tools for measuring bone in children and adolescents -- 3. Dual-energy X-Ray absorptiomery technology -- 4. Indications for DXA in children and adolescents -- 5. Acquisition of DXA in children and adolescents -- 6. Analysis and evaluation of DXA in children and adolescents -- 7. Reporting DXA results for children and adolescents -- 8. DXA evaluation of infants and toddlers -- 9. DXA in children with special needs -- 10. Bone mineral density as a predictor of vertebral fractures in children and adolescents -- 11. Lessons learned from clinical research using QCT, pQCT, and HR-pQCT -- 12. Evaluation of fracture without known trauma: use of DXA in differential diagnosis -- 13. What's next in the field of bone health in pediatrics? Research considerations -- Appendix A -- Appendix B -- Appendix C -- Appendix D -- Index.
  • Digital
    Theofilos Karachalios, editor.
    Springer2014
    What is the optimal design and fixation of the implants we use for orthopedic reconstructions? What is the gold standard for the management of patients requiring implants? Is there scope for improvement still further? Huge efforts have been made both by research scientists in orthopedics and the implant industry to furthering the options available for arthroplasty without necessarily considering the cost-effectiveness of this research to clinical outcomes. It has also become apparent that theoretical and laboratory studies do not always match the results of long-term clinical studies of which there regretfully few of sufficient quality. The Editor and his carefully chosen selection of contributors critically evaluate data from basic science, experimental in vivo and in vitro biological and mechanical models, autopsy specimens and long-term clinical studies to answer these questions. Bone-Implant Interface in Orthopedic Surgery: Basic Science to Clinical Applications focuses on the bone-orthopedic implant interface in general and will be useful both for the novice who seeks a quick introduction to this specific topic and for more experienced surgeons who seek an in depth critical review of current practices.
  • Digital
    edited by Meral Beksac.
    Springer Protocols2014
    Reporter Gene Technologies for Imaging Cell Fates in Hematopoiesis / Sophie Kusy and Christopher H. Contag -- Flow Cytometry for Hematopoietic Cells / Daniela S. Krause, Michelle E. DeLelys, and Frederic I. Preffer -- Isolation and Characterization of Mesenchymal Stem Cells / Sedat Odabas, A. Eser Elçin, and Y. Murat Elçin -- Methods for Functional Analysis of Stem Cells / Michelle Escobedo-Cousin, J. Alejandro Madrigal, and Aurore Saudemont -- An Overview of HLA Typing for Heamatopoietic Stem Cell Transplantation / Katy Latham, Ann-Margaret Little, and J. Alejandro Madrigal -- HLA Typing with Sequence-Specific Oligonucleotide Primed PCR (PCR-SSO) and Use of the Luminex Technology / Klara Dalva and Meral Beksaç -- Sequence Based Typing of HLA: An Improved Group Specific Full Length Gene Sequencing Approach / Christina E.M. Voorter, Fausto Palusci, and Marcel G.J. Tilanus -- Molecular Typing Methods for Minor Histocompatibility Antigens / Eric Spierings -- Natural Killer Cells and Killer-cell Immunoglobulin-like Receptor Polymorphisms: Their Role in Hematopoietic Stem Cell Transplantation / Jennifer Schellekens, Katia Gagne, and Steven G.E. Marsh -- Methods of Detection of Immune Reconstitution and T Regulatory Cells by Flow Cytometry / Richard Charles Duggleby and J. Alejandro Madrigal -- Molecular Methods Used for Detection of Minimal Residual Disease Following Hematopoietic Stem Cell Transplantation in Myeloid Disorders / Ahmet H. Elmaagacli -- Molecular Methods for Detection of Minimal Residual Disease Following Transplantation in Lymphoid and Plasma Cell Disorders / Paolo Corradini and Cristiana Carniti -- Molecular Methods for Detection of Invasive Fungal Infections and Mycobacteria and Their Clinical Significance in Hematopoietic Stem Cell Transplantation / Pinar Yurdakul and Sule Colakoglu -- Post-transplant Monitoring of Chimerism by Lineage-specific Analysis / Sandra Preuner and Thomas Lion -- Urinary Proteomics Employing Capillary Electrophoresis Coupled to Mass Spectrometry in The Monitoring Of Patients After Stem Cell Transplantation / Eva M. Weissinger, William Mullen, and Amaya Albalat.
  • Digital
    Dimitra Anagnostou, Estella Matutes, editors.
    Springer2012
    1. New Insights in the Development of Human B Lymphocytes / Bianca Blom -- 2. The Aging Lymphocyte / Hector F. Valenzuela, Rita B. Effros -- 3. The Bone Marrow Microenvironment and Its Impact in Acute and Chronic B Cell Malignancies / Jan A. Burger -- 4. The Expanding Diagnostic Role of Flow Cytometry in Bone Marrow Studies of Patients with Lymphomas and Plasma Cell Disorders / Anna Porwit -- 5. The Application of Molecular Techniques on Bone Marrow Trephines / Falko Fend, Leticia Quintanilla-Martínez -- 6. Residual Disease Assessment and Its Role in Monitoring Lymphoid and Plasma Cell Neoplasms / Konnie M. Hebeda -- 7. Reporting of Bone Marrow Lymphoid Infiltrates / Yi-Hua Chen, LoAnn Peterson -- 8. Janus-Faced Lymphoid Infiltrates / Dimitra Anagnostou -- 9. Singularities in Pediatric Bone Marrow Lymphoid Processes / Sophia L. Yohe, Robert W. McKenna -- 10. Bone Marrow Involvement in Primary Mature B and T Cell Leukemias / Ayoma D. Attygalle -- 11. A Step Forward in the Diagnosis of B-Cell Lymphomas in the Bone Marrow / Ahmet Dogan, Mine Hekimgil -- 12. New Insights in Waldenström's Macroglobulinemia / Meletios A. Dimopoulos, Evangelos Terpos -- 13. Bone Marrow in Hodgkin Lymphoma and Mimickers / Stefano A. Pileri, Elena Sabattini -- 14. Misleading Features of Bone Marrow Involvement by Peripheral T-Cell Lymphomas / Philippe Gaulard, Sylvia Hoeller -- 15. Systemic Mastocytosis Associated with Lymphoproliferative Disorders (SM-AHNMD) / Hans-Peter Horny, Karl Sotlar, Peter Valent.
  • Digital
    Lia Angela Moulopoulos, Vassilis Koutoulidis.
    Springer2015
    MRI provides the best means of imaging the bone marrow directly and of non-invasively assessing its composition. Normal age-related bone marrow changes, alterations related to red marrow reconversion, and pathological bone marrow processes generally conform to certain patterns that reflect the underlying marrow changes and can be clearly recognized on MR images. In addition to conventional pulse sequences, advanced MRI techniques such as Dynamic Contrast-Enhanced MRI and Diffusion-Weighted Imaging depict marrow changes at the microvascular and cellular level respectively. This book provides radiologists with in-depth information on the MRI appearances of normal, abnormal and treated marrow following a structured, pattern-based approach. MRI findings for various diseases that affect the bone marrow, particularly those of a malignant nature, are presented in detail. MRI pattern recognition not only offers a systematic approach to image interpretation and diagnosis but also has prognostic implications with regard to some disease entities. Each chapter includes a wealth of high-quality images, together with Key Points summarizing the most important information. In addition to radiologists, practitioners with an interest in hematology and oncology will find this textbook-atlas to be a valuable resource for the latest, clinically relevant advances in bone marrow imaging.
  • Print
    Barbara J. Bain, David M. Clark, Bridget S. Wilkins.
    Status: Not Checked OutLane Catalog Record
    The normal bone marrow -- Special techniques applicable to bone marrow diagnosis -- Infection and reactive changes -- Acute myeloid leukaemia, mixed phenotype acute leukaemia, the myelodysplastic syndromes, and histiocytic neoplasms -- Myeloproliferative and myelodysplastic/myeloproliferative neoplasms and related conditions -- Lymphoproliferative disorders -- Plasma cell neoplasms -- Disorders of erythropoiesis, granulopoiesis and thrombopoiesis -- Miscellaneous disorders -- Metastatic tumours -- Diseases of bone.
  • Digital
    Felix Bronner, Mary C. Farach-Carson, Helmtrud I. Roach, editor[s].
    Springer2012
    Parathyroid Hormone and Parathyroid-Hormone-Related Protein: Normal Function, Diseases, and Emerging Therapeutics / Ling Qin and Nicola C. Partridge -- Vitamin D: Normal Function, Metabolism, Diseases, and Emerging Therapeutics / René St-Arnaud and Marie B. Demay -- Gonadal Hormones, Diseases, and Emerging Therapeutics / Faryal S. Mirza, Liam Zakko and Pamela Taxel -- Thyroid and Thyroid Hormone: Normal Function, Diseases, Disorders, Emerging Therapeutics / Paula H. Stern -- Pituitary Hormones and the Pathophysiology of Osteoporosis / Manasi Agrawal, Shitij Arora, Graziana Colaianni, Li Sun and Jameel Z. Iqbal, [et al.] -- Calcitonin: Its Physiological Role and Emerging Therapeutics / Jillian Cornish, Dorit Naot and T. John Martin -- Glucocorticoids, Inflammation, and Bone / Kong Wah Ng and T. John Martin -- Diseases of Energy and Lipid Metabolism and Bone: Emerging Therapeutics / Sumithra K. Urs and Clifford J. Rosen -- Diseases of Mineral Metabolism and Bone: Emerging Therapeutics for Postmenopausal Osteoporosiss / Paul D. Miller -- Renal Diseases and Bone: Emerging Therapeutics / Nancy S. Krieger and David A. Bushinsky -- Wasting Diseases and Metabolic Impact on Bone: Emerging Therapeutics and Treatment Options / Linda A. DiMeglio -- Paget's Disease of Bone: Pathogenesis and Treatment / Frederick R. Singer and G. David Roodman -- Bone Loss in Space Flight and Countermeasures /; Adrian D. LeBlanc, Elisabeth R. Spector and Victor S. Schneider --; Osteoimmunology: Relation to Disease and Therapy /; M. Neale Weitzmann and Roberto Pacifici -- Bone and the Ear / Kathleen C. Horner -- Bone and the cAMP Signaling Pathway: Emerging Therapeutics / Paul M. Epstein -- Nervous System Diseases, Disorders, and Bone: Emerging Therapeutics and Treatment Options / Mary F. Barbe and Steven N. Popoff.
  • Digital
    edited by Dimitrios Kardamakis, Vassilios Vassiliou and Edward Chow.
    Springer2009
    Focusing on the field of metastatic bone disease, this volume: describes the molecular and cellular mechanisms involved in the formation of bone metastases, comments on the role of angiogenesis, and, deals with various aspects of imaging modalities applied for the detection and evaluation of bone metastases.
  • Digital
    Dimitrios Kardamakis, Vassilios Vassiliou, Edward Chow, editors.
    Springer2014
    The second edition of this book serves both as an introductory and reference book focusing on the field of metastatic bone disease. Featuring contributions from experts in the field, this volume describes the molecular and cellular mechanisms involved in the formation of bone metastases, presents the newer advances made in the understanding of the clinical picture and symptoms of patients, analyses the role of bone markers in research and clinical practice and deals with all aspects of imaging modalities applied for the detection and evaluation of bone metastases. Moreover, the use of all available treatment methods, such as radiotherapy, surgery and systemic treatments for the management of patients with metastatic bone disease is discussed in detail. Overall this volume presents a thorough overview of all aspects of metastatic bone disease and provides a comprehensive and concise information resource for researchers, oncologists, orthopaedic surgeons and clinicians dealing with patients with metastatic bone disease.
  • Digital
    Anja Rose Scholze.
    Astrocytes constitute a major cell population in the brain with a myriad of essential functions, yet we know remarkably little about the signaling pathways and mechanisms that direct astrocyte maturation. To explore the signals regulating astrocyte development, we prospectively purified and cultured immature postnatal rodent astrocytes. We identified fibroblast growth factors (FGFs) and bone morphogenetic proteins (BMPs) as robust trophic factors for immature astrocytes. We showed that astrocytes respond directly to BMPs via phosphorylation of the smad1/5/8 pathway. In vitro, BMP signaling promoted immature astrocytes to adopt multiple characteristics of mature astrocytes, including a more process-bearing morphology, aquaporin-4 (AQP4) and S100 [beta] immunoreactivity, limited proliferation, and strong downregulation of epidermal growth factor receptor (EGFR). In vivo, activation of the smad1/5/8 pathway in astrocytes was seen during early postnatal development, but inhibition of astrocyte proliferation was not observed. These insights can aid in the further dissection of mechanisms and pathways controlling astrocyte biology and development.
  • Digital/Print
    edited by Slobodan Vukicevic, Kuber T. Sampath.
    Digital : Springer2006
    Print2008
  • Print
    edited by Slobodan Vukicevic, Kuber T. Sampath.
    Status: Not Checked OutLane Catalog Record
    Historical perspective of bone morphogenetic proteins -- The systems biology of bone morphogenetic proteins -- Embryonic skeletogenesis and craniofacial development -- BMP and BMP regulation: structure and function -- Novel in vitro assay models to study osteogenesis and chondrogenesis for human skeletal disorders -- Toward advanced therapy medicinal products (ATMPs) combining bone morphogenetic proteins (BMP) and cells for bone regeneration -- BMP signaling in articular cartilage repair and regeneration: potential therapeutic opportunity for osteoarthritis -- BMPs in orthopaedic medicine: promises and challenges -- Osteogrow: a novel graft substitute for orthopedic reconstruction -- Biology of spine fusion and application of osteobiologics in spine surgery -- BMPs in dental medicine: promises and challenges -- Bone morphogenetic protein-7 and its role in acute kidney injury and chronic kidney failure -- Bone morphogenetic protein signaling in pulmonary arterial hypertension -- BMP signaling in fibrodysplasia ossificans progressiva, a rare genetic disorder of heterotopic ossification -- The central role of BMP signaling in regulating iron homeostasis -- BMPs in inflammation -- Physiological and pathological consequences of vascular BMP signaling -- Bone morphogenetic proteins in the initiation and progression of breast cancer.
  • Digital
    Jasvir S. Khurana, editor.
    Springer2009
    Bone structure, development and bone biology -- Structure and function of joints -- Biomechanics: part I -- Biomechanics: part II -- Laboratory in orthopedic practice -- Genetics and molecular biology of bone and soft tissue tumors -- Grossing of bone and soft tissue (common specimens and procedures) -- Bone histomorphometry and undecalcified sections -- Radiology of the musculoskeletal system -- Skeletal trauma and common orthopedic problems -- Surgical pathology of bone infections -- Arthropathies -- Surgical pathology of prosthetic materials -- Osteoporosis and metabolic bone disease -- Inherited and dysplastic conditions of the skeleton -- Musculoskeletal neoplasms: an introduction -- Medical management of sarcomas -- Radiation therapy for sarcomas -- Surgical pathology of bone tumors and tumor-like lesions -- Tumors of soft tissue.

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