Lane Medical Library

Books

B

  • Digital
    [edited by] Carol D. Berkowitz.
    ProQuest Ebook Central2011
    Section I. Primary care : skills and concepts -- Section II. Health maintenance and anticipatory guidance -- Section III. Acute and emergent problems -- Section IV. Head, neck, and respiratory system -- Section V. Hematologic disorders -- Section VI. Cardiovascular system -- Section VII. Genitourinary disorders -- Section VIII. Orthopedic disorders -- Section IX. Gastrointestinal disorders -- Section X. Neurologic disorders -- Section XI. Dermatologic disorders -- Section XII. The new morbidity -- Section XIII. Chronic diseases of childhood and adolescence.
  • Digital
    [edited by] Lalit Bajaj, Simon Hambidge, Ann-Christine Nyquist, Gwendolyn Kerby.
    ScienceDirect2011
  • Print
    editors, Bruce M. Koeppen, Bruce A. Stanton.
    Status: Not Checked OutLane Catalog Record
    Principles of cell function -- Homeostasis of body fluids -- Signal transduction, membrane receptors, second messengers, and regulation of gene expression -- The nervous system: introduction to cells and systems -- Generation and conduction of action potentials -- Synaptic transmission -- The somatosensory system -- The special senses -- Organization of motor function -- Higher functions of the nervous system -- The autonomic nervous system and its central control -- Sketetal muscle physiology -- Cardiac muscle -- Smooth muscle -- Overview of circulation -- Elements of cardiac function -- Properties of the vasculature -- Regulaiton of the heart and vasculature -- Integrated control of the cardiovascular system -- Structure and function of the respiratory system -- Mechanical properties of the lung and chest wall: static and dynamic -- Ventilation (V̇), perfusion (Q̇), and V̇/Q̇ relationships -- Oxygen and carbon dioxide transport -- Control of respiration -- Nonrespiratory functions of the lung -- Functional anatomy and general principles of regulation in the gastrointestinal tract -- The cephalic, oral, and esophageal phases of the integrated response to a meal -- The gastric phase of the integrated response to a meal -- The small intestinal phase of the integrated response to a meal -- The colonic phase of the integrated response to a meal -- Transport and metabolic functions of the liver -- Elements of renal function -- Solute and water transport along the nephron: tubular function -- Control of body fluid osmolality and volume -- Potassium, calcium, and phosphate homeostasis -- Role of the kidneys in the regulation of acid-base balance -- Introduction to the endocrine system -- Hormonal regulation of energy metabolism -- Hormonal regulation of calcium and phosphate metabolism -- The hypothalamus and pituitary gland -- The thyroid gland -- The adrenal glands -- The male and female reproductive systems.
  • Digital
    editors, Bruce M. Koeppen, Bruce A. Stanton.
    ClinicalKey2018
    Principles of cell and membrane function -- Homeostasis : volume and composition of body fluid compartments -- Signal transduction, membrane receptors, second messengers, and regulation of gene expression -- The nervous system : introduction to cells and systems -- Generation and conduction of action potentials -- Synaptic transmission -- The somatosensory system -- The special senses -- Organization of motor function -- Integrative functions of the nervous system -- The autonomic nervous system and its central control -- Skeletal muscle physiology -- Cardiac muscle -- Smooth muscle -- Overview of circulation -- Elements of cardiac function -- Properties of the vasculature -- Regulation of the heart and vasculature -- Integrated control of the cardiovascular system -- Introduction to the respiratory system -- Static lung and chest wall mechanics -- Dynamic lung and chest wall mechanics -- Ventilation, perfusion, and ventilation/perfusion relationships -- Oxygen and carbon dioxide transport -- Control of respiration -- Nonphysiological functions of the lung : host defense and metabolism -- Functional anatomy and general principles of regulation in the gastrointestinal tract -- The cephalic, oral, and esophageal phases of the integrated response to a meal -- The gastric phase of the integrated response to a meal -- The small intestinal phase of the integrated response to a meal -- The colonic phase of the integrated response to a meal -- Transport and metabolic functions of the liver -- Elements of renal function -- Solute and water transport along the nephron : tubular function -- Control of body fluid osmolality and volume -- Potassium, calcium, and phosphate homeostasis -- Role of the kidneys in the regulation of acid-base balance -- Introduction to the endocrine system -- Hormonal regulation of energy metabolism -- Hormonal regulation of calcium and phosphate metabolism -- The hypothalamus and pituitary gland -- The thyroid gland -- The adrenal gland -- The male and female reproductive systems.
  • Digital
    Jeffrey J. Peterson.
    Ovid2018
    "Berquist's Musculoskeletal Imaging Companion is a practical quick-reference guide to the radiologic diagnosis of musculoskeletal disorders. It presents over 1500 large, clear images of common diseases, disorders, and injuries, accompanied by succinct, bulleted "key facts" about the clinical and imaging features of each condition. Chapters cover all anatomic regions and disease entities, imaging of orthopaedic appliances and prostheses, and detailed protocols for all current imaging modalities. The book demonstrates the utility of multiple modalities in specific situations and recommends the best, most cost-effective approach"--Provided by publisher.
  • Digital
    Gary D. Stoner, Navindra P. Seeram, editors.
    Springer2011
    Experimental investigations in the past 10-15 years have provided convincing evidence of the cancer preventive potential of berries. Berries and their components have been shown to reduce the malignant properties of cancer cells in culture by influencing genes associated with cancer development. In addition, diets containing freeze-dried berries have been shown to prevent cancer in animals, and recent data indicate that they also exhibit cancer preventive effects in humans.
  • Digital
    Committee on the Learning Health Care System in America ; Mark Smith, Robert Saunders, Leigh Stuckhardt, J. Michael McGinnis, editors.
  • Digital
    editors, Rahul Jandial, Steven R. Garfin ; associate editors, Christopher Ames [and others].
    ScienceDirect2012
    ClinicalKey2012
    Cervical disk herniation : anterior cervical diskectomy and fusion versus arthroplasty / Mir H. Ali, Frank M. Phillips -- Multilevel anterior cervical diskectomy and fusion : bone-grafting options / Sheeraz A. Qureshi, Andrew C. Hecht, Scott D. Boden -- Ossification of the posterior longitudinal ligament : anterior versus posterior approach / Garrick W. Cason, Edward R. Anderson III, Harry N. Herkowitz -- Minimally invasive approaches to thoracic disk herniations / Alfred T. Ogden, Michael G. Kaiser, Richard G. Fessler -- Lumbar disk herniation with mild neurological deficit : microdiskectomy versus conservative treatment / Kelli L. Crabtree, Paul M. Arnold -- Cervical spondylosis-spinal stenosis : laminoplasty versus laminectomy and fusion / Yu-Po Lee, Niraj Patel, Steven R. Garfin -- Lumbar degenerative disk disease : fusion versus artificial disk / Michael F. Duffy, Jack E. Zigler -- Degenerative spondylolisthesis with radicular pain : decompression only versus decompression and fusion / Tuan V. Nguyen, Robert A. McGuire Jr. -- Asymptomatic intradural Schwannoma : surgery versus radiosurgery versus observation / Christopher E. Mandigo, Paul C. McCormick -- Pseudotumor : transoral versus posterior fusion / Daniel M. Sciubba ... [et al.] -- Odontoid fracture in the elderly : odontoid screws versus posterior fusion / Harvey E. Smith, Scott D. Daffner, Alexander R. Vaccaro -- C1-C2 fusion : transarticular screws versus Harms procedure / Thomas J. Kesman, Bradford L. Currier -- Multilevel cervical corpectomy : anterior-only versus circumferential instrumentation / Andrew J. Schoenfeld, Christopher M. Bono -- Cervical jumped facets and incomplete neurological deficit : closed reduction versus urgent surgery / Michael A. Finn, Paul A. Anderson -- Laminectomy across cervico thoracic junction : fusion versus non fusion / Timothy E. Link, Rahul Jandial, Volker K.H. Sonntag -- Vertebral metastases : ventral and dorsal approach versus lateral -- Extracavitary transpedicular approach / John H. Shin, Edward C. Benzel -- Degenerative scoliosis: anterior and posterior fusion versus posterior fusion / Krishna Gumidyala, Sigurd Berven -- Sagittal imbalance: multiple Smith-Petersen osteotomies versus pedicle substraction osteotomies / Jamal McClendon ... [et al.] -- -- L1-S1 fusion: extending to T12 and pelvis and when to include L5-S1 anterior grafting / Steven Mardjetko -- High-grade spondylolisthesis : reduction and fusion versus in situ fusion / Matthew B. Maserati, Christopher I. Shaffrey, Adam S. Kanter.
  • Digital
    Rachel E. Golden, Charles B. Collins, Shayna D. Cunningham, Emily N. Newman, Josefina J. Card.
    Springer2013
    Introduction -- Overview of Structural Interventions to Decrease Injection Drug-Use Risk -- Overview of Structural Interventions to Decrease Noncommercial Sex Risk -- Overview of Structural Interventions to Decrease Commercial Sex Risk -- Overview of Structural Interventions to Increase Voluntary Counseling and Testing (VCT) and Antiretroviral Therapy (ART) -- Conclusion.
  • Print
    Status: Not Checked OutLane Catalog Record
  • Print
    Status: Not Checked OutLane Catalog Record
  • Digital
    Bruce L. Gewertz, Dave C. Logan.
    Springer2015
  • Digital
    edited by Sir Sabaratnam Arulkumaran.
    Cambridge2016
    "An understanding of when and how to intervene is the key to good obstetric care. This textbook is an encompassing reference covering all the essential information relating to childbirth; it offers clear practical guidance on all aspects of labour and delivery. Written by well-known leading experts, each chapter offers a modern authoritative review of best practice. The evidence base decribed will help to optimize outcome through appropriate clinical management and justifiable intervention. Whilst this is an ideal textbook for those training and taking examinations in labour ward practice, it offers all those caring for the woman in labour a modern, evidence-based approach which will help them understand, recognize and deliver the best possible clinical care. The importance of team working, prioritizing, and the organization of maternity care receive appropriate emphasis with clear guidance and practical advice"--Provided by publisher.
  • Print
    Friedman, Yali.
    Status: Not Checked OutLane Catalog Record
  • Digital
    editor, Bruce Ovbiagele.
    Future Med2014
    Best practices in neurological care / Bruce Ovbiagele -- Epilepsy / Omotola A. Hope & Jeremy Lankford -- Parkinson's disease / Jori Fleisher & Nabila Dahodwala -- Neuromuscular diseases / Hajime Tokuno, Pooia Fattahi & Huned S. Patwa -- Dementia / Liana G. Apostolova -- Headache / Charles C. Flippen II -- Brain tumor management / Seema Nagpal, Scott G. Soltys, Gordon Li, Griffith Harsh & Lawrence Recht -- Neuroinfectious diseases / David Croteau -- Stroke / Shelly Ozark, Diana Goodman & Christine Holmstedt -- Multiple sclerosis / Lily Jung Henson -- Evidence-based therapies in neurologic rehabilitation / Bruce H. Dobkin & Andrew Dorsch -- Neurocritical care / Paul Vespa & Vikas Grover -- Palliative care in neurology / Eli L. Diamond & Alan C. Carver -- Index.
  • Print
    edited by Jodie A. Trafton, William P. Gordon.
    Status: Not Checked OutLane Catalog Record
    v. 1. Neuropsychiatric disorders -- v. 2. Other medical disorders -- v. 3. [without special title].
  • Digital/Print
    Marco Fioroni, Tamara Dworeck, Francisco Rodriguez-Ropero.
    Digital : Springer2014
    Print2014
    β-barrel outer membrane channel proteins (OMP) have great potential as robust and flexible models or components in nanotechnology. Over the last decade biotechnological techniques allowed to expand the natural characteristics of OMPs by modifying their geometry and properties without affecting the overall protein structure and stability. The present book is oriented towards a broad group of readers including graduate students and advanced researchers. The β-barrel structure serviceability for the nano-material design will be its chief topic giving a general introduction to the field of OMP based nano-component development as well as the state of the art of the involved research. On the example of the E. coli FhuA the transformation of an OMP into a tailored nano-channel to be adapted to a non-biological synthetic (i.e. polymer) environment, rendering it competitive with artificial non-biological nano-pores will be outlined specifically the design of a set of protein nano-channels with tailored geometry (diameter, length), conductance and functionality will be reported as a case study. In order to make this book a valuable source of information for both biotechnologists and other scientists interested in bio-nanotechnology an overview of the different steps involved in the nano-channel protein design and production will be reported. The scientific strategy from concept design, theoretical considerations, genetic engineering and large scale production, to system assembly and biophysical characterization with an overview on technological applications including membrane/polymersome technology, will be described.
  • Digital
    edited by R. Willenheimer, E. Erdmann.
    HighWire2009
  • Digital
    [edited by] Bernhelm Booss-Bavnbek, Beate Klösgen, Jesper Larsen, Flemming Pociot, Erik Renström.
    Springer2011
    pt. 1. Systems biology approach to [beta]-cells -- pt. 2. Imaging and sensors -- pt. 3. Genetics and proteomics -- pt. 4. Physiological, pharmaceutical and clinical applications and perspectives -- pt. 5. Mathematical modelling and numerical simulation.
  • Digital
    editors, Jame Abraham, James L. Gulley, Carmen J. Allegra.
    Ovid2014
    Head and neck cancer -- Non-small cell lung cancer -- Small cell lung cancer -- Esophageal cancer -- Gastric cancers -- Biliary tract cancers -- Primary cancers of the liver -- Colorectal cancer -- Pancreatic cancer -- Anal cancer -- Other gastrointestinal tumors -- Breast cancer -- Renal cell cancer -- Prostate cancer -- Bladder cancer -- Testicular carcinoma -- Ovarian cancer -- Endometrial cancer -- Cervical cancer -- Vulvar cancer -- Sarcomas and malignancies of the bone -- Skin cancers and melanoma -- Acute leukemia -- Chronic lymphoid leukemias -- Chronic myeloid leukemia -- Chronic myeloproliferative neoplasms -- Multiple myeloma -- Non-Hodgkin lymphoma -- Hodgkin lymphoma -- Hematopoietic cell transplantation -- Carcinoma of unknown primary -- Central nervous system tumors -- Endocrine tumors -- Hematopoietic growth factors -- Infectious complications in oncology -- Oncologic emergencies and paraneoplastic syndromes -- Psychopharmacologic management in oncology -- Management of emesis -- Medical nutrition therapy -- Pain and palliative care -- Central venous access device -- Procedures in medical oncology -- Diagnosis-driven individualization of cancer care -- Basic principles of radiation oncology -- Clinical genetics -- Anticancer agents.
  • Digital
    Ritu Nayar, David C. Wilbur, editors.
    Springer2015
    This book offers clear, up-to-date guidance on how to report cytologic findings in cervical, vaginal and anal samples in accordance with the 2014 Bethesda System Update. The new edition has been expanded and revised to take into account the advances and experience of the past decade. A new chapter has been added, the terminology and text have been updated, and various terminological and morphologic questions have been clarified. In addition, new images are included that reflect the experience gained with liquid-based cytology since the publication of the last edition in 2004. Among more than 300 images, some represent classic examples of an entity while others illustrate interpretative dilemmas, borderline cytomorphologic features or mimics of epithelial abnormalities. The Bethesda System for Reporting Cervical Cytology, with its user-friendly format, is a must have for pathologists, cytopathologists, pathology residents, cytotechnologists, and clinicians.
  • Digital
    Syed Z. Ali, Edmund S. Cibas, editors.
    Springer2010
  • Digital
    edited by Gerd Gigerenzer and J.A. Muir Gray.
    ProQuest Ebook Central2011
    Health literacy : is the patient the problem? -- Launching the century of the patient / Gerd Gigerenzer and J.A. Muir Gray -- When misinformed patients try to make informed health decisions / Wolfgang Gaissmaier and Gerd Gigerenzer -- Reducing unwarranted variation in clinical practice by supporting clinicians and patients in decision making / Albert G. Mulley, Jr., and John E. Wennberg -- Do patients want shared decision making and how is this measured? / Martin Hañrter and Daniela Simon -- Health illiteracy : roots in research -- Health research agendas and funding / David E. Nelson -- Reporting of research : are we in for better health care by 2020? / Holger Schanemann, Davina Ghersi, Julia Kreis, Gerd Antes, and Jean Bousquet -- Medical journals can be less biased / J.A. Muir Gray -- What is needed for better health care : better systems, better patients or both? / Markus A. Feufel, Gerd Antes, Johann Steurer, Gerd Gigerenzer, J.A. Muir Gray, Marjukka MÃñkelÃñ, Albert G. Mulley, Jr., David E. Nelson, Jay Schulkin, Holger Schanemann, John E. Wennberg, and Claudia Wild -- Health illiteracy : spread to the public -- Statistical illiteracy in doctors / Odette Wegwarth and Gerd Gigerenzer -- Statistical illiteracy in journalism : are its days numbered? / Bruce Bower -- Improving health care journalism / Holger Wormer -- Barriers to health information and building solutions / Talya Miron-Shatz, Ingrid Mahlhauser, Bruce Bower, Michael Diefenbach, Ben Goldacre, Richard S.W. Smith, David Spiegelhalter, and Odette Wegwarth -- Health care 2020 -- How can better evidence be delivered? / Norbert Donner-Banzhoff, Hilda Bastian, Angela Coulter, Glyn Elwyn, Gunther Jonitz, David Klemperer, and Wolf-Dieter Ludwig -- The drug facts box : making informed decisions about prescription drugs possible / Lisa M. Schwartz and Steven Woloshin -- Reengineering medical education / David A. Davis -- The chasm between evidence and practice : extent, causes, and remedies / Richard S.W. Smith -- The future of diagnostics : from optimizing to satisficing / Henry Brighton -- Direct-to-consumer advertising : status quo and suggestions to enhance the delivery of independent medication information / Wolf-Dieter Ludwig and Gisela Schott -- How will health care professionals and patients work together in 2020? : a manifesto for change / Ralph Hertwig, Heather Buchan, David A. Davis, Wolfgang Gaissmaier, Martin Harter, Kai Kolpatzik, France LÃgarÃ, Norbert Schmacke, and Holger Wormer.
  • Digital
    Bruce Guthrie, Alexander Thompson, Siobhan Dumbreck, Angela Flynn, Phil Alderson, Moray Nairn, Shaun, Treweek, and Katherine Payne.
    1. Background to the project -- 2. Initial work examining how three exemplar guidelines accounted for multimorbidity -- The applicability of evidence used to inform clinical guideline treatment recommendations -- 4. Comparing treatments in terms of absolute benefit -- 5. Including a temporal dimension in model-based cost-effectiveness analysis: an application to the use of statins in primary prevention of cardiovascular disease -- 6. Quantifying the impact of multimorbidity in a model-based cost-effectiveness analysis -- 7. Summary and conclusions.
  • Digital
    Ulrich Dobrindt, Jörg H. Hacker, Catharina Svanborg, editors.
    Springer2013
    E. coli as an All-Rounder: The Thin Line Between Commensalism and Pathogenicity / Andreas Leimbach, Jörg Hacker, Ulrich Dobrindt -- What Distinguishes Highly Pathogenic Staphylococci from Medium- and Non-pathogenic? / Ralf Rosenstein, Friedrich Götz -- Microevolution of Pseudomonas aeruginosa to a Chronic Pathogen of the Cystic Fibrosis Lung / Michael Hogardt, Jürgen Heesemann -- Lactobacillus: Host-Microbe Relationships / John O'Callaghan, Paul W. O'Toole -- Bacterial Moonlighting Proteins and Bacterial Virulence / Brian Henderson, Andrew Martin -- Symbionts and Pathogens: What is the Difference? / Vicente Pérez-Brocal, Amparo Latorre, Andrés Moya -- Ecology and Physiology of the Intestinal Tract / Michael Blaut -- The Gut Microflora and Its Variety of Roles in Health and Disease / Julia-Stefanie Frick, Ingo B. Autenrieth -- Host-Recognition of Pathogens and Commensals in the Mammalian Intestine / Oriana Rossi, Peter van Baarlen, Jerry M. Wells -- Contribution of the Intestinal Microbiota to Human Health: From Birth to 100 Years of Age / Jing Cheng, Airi M. Palva, Willem M. de Vos.
  • Digital
    edited by Leonid Padyukov.
    ScienceDirect2014
    Between the Lines of Genetic Code lays out methodologies and tools for the measurement and evaluation of gene-gene and gene-environment studies and gives perspective on the future of this discipline. The book begins by defining terms for interaction studies, describing methodologies, and critically assessing the viability of current study designs and the possibilities for integrating designs. It then provides recent applications data with case studies in rheumatoid arthritis, multiple sclerosis, myositis and other complex human diseases. Last, it examines current studies and directions for future applications in patient care. Recent multivariate studies show that gene-gene and gene-environment interactions can explain significant variances in inheritance that have previously been undetectable in univariate analysis. These links among genes and between genes and their environments during the development of diseases may serve as important hints for understanding pathogenic mechanisms and for developing new tools for prognosis, diagnosis, and treatment of various diseases. Systematically integrates methods of defining and detecting gene interactions to provide an overview of the field. Critically analyzes current methods and tools to aid researchers in integrating gene interaction studies Includes examples of current biomedical applications and presents current research expected to shape clinical research in the near future.
  • Digital
    Ted Wilson, Norman J. Temple, editors.
    Springer2016
    Part 1: Introduction to Beverages -- How Beverages Impact Health and Nutrition -- A Brief History of Human Beverage Consumption: Pre-History to the Present -- Part 2: Health Effects of Coffee, Tea, Wine, Alcohol, and Juices -- Coffee consumption and its impact on health -- Health Benefits of Tea Consumption -- What are the Health Implications of Alcohol Consumption?- Nonalcoholic Components of Wine and Atherosclerotic Cardiovascular Disease -- Cranberry Juice: Effects on Health -- Citrus Juices Health Benefits -- Part 3: Health Effects of Milk: Dairy, Soy and Breast -- Effect of Cow's Milk on Human Health -- Are soy-milk products viable alternatives to cow's milk?- Human Milk and Infant Formula: Nutritional Content and Health Benefits -- Part 4: Beverage Health Effects on Energy Balance, Diabetes, and in Older Adults.-Beverages, satiation, satiety, and energy balance -- Beverage Considerations for Persons with Metabolic Syndrome and Diabetes Mellitus -- Oral Nutritional Supplementation Using Beverages for Older Adults -- Part 5: Health Effects of Sports Drinks, Energy Drinks and Water -- Sports Beverages for Optimizing Physical Performance -- Energy Drinks: the Elixirs of Our Time -- The Nutritional Value of Bottled Water -- Part 6: Marketing of Soft Drinks and Effects of Beverage Sweeteners -- Marketing of Soft Drinks to Children and Adolescents: Why we Need Government Policies -- Sugar in Beverages: Effects on Human Health -- High fructose corn syrup use in beverages: Composition, manufacturing, properties, consumption, and health effects -- Part 7: Beverage Mechanics: Color, Taste, Labeling, and Ingredient Function -- The crucial role of color in the perception of beverages -- Functions of Common Beverage Ingredients -- Labeling Requirements for Beverages in the United States -- Part 8: What is the Future of What We Will Chose to Drink?- Beverage Trends Affect Future Nutritional Health Impact.
  • Digital
    A. George Awad, Lakshmi N.P. Voruganti, editors.
    Springer2016
    Part I:Basic and Conceptual Issues -- Schizophrenia and it's sequelae -- Issues that slowed progress in the assessment of health-related quality of life in schizophrenia -- Social cognition and health-related quality of life in schizophrenia -- Conceptual issues in cultural adaptation and the role of culture in assessment of health-related quality of life in schizophrenia -- Part II:Methodological Issues -- A review of quality of life assessment measures in schizophrenia -- limitations and future developments -- a review -- Assessment of burden of care and quality of life of caregivers in schizophrenia -- Electronic technology and advances in assessment of outcomes -- Modern psychometric approaches to analysis of scales for health-related quality of life -- Part III:Beyond Assessment of Quality of Life in Schizophrenia -- Health-related quality of life as an outcome and mediator of other outcomes -- Using routine quality of life assessment to improve effectiveness of community mental health care -- Quality of life assessments in the development and clinical trials of new antipsychotics -- pharmaceutical industry perspective -- Quality of life and health-costs -- the feasibility of cost-utility analysis in schizophrenia -- Health-related quality of life in schizophrenia: health policy and resource allocation -- Beyond assessment of quality of life in schizophrenia: cultural, clinical and research perspectives from India -- a case study -- Part IV:Reinventing Quality of Life in Schizophrenia -- Concluding remarks and future challenges.
  • Digital
    Cliff Atkinson
    ProQuest Safari2007
    A guide to using Microsoft PowerPoint describes how to use storytelling techniques to create effective business presentations.
  • Print
    Jacqueline Benjamin.
    Status: Not Checked OutLane Catalog Record
  • Digital
    George Ellis and Mark Solms.
    Cambridge2017
    1. Introduction -- 2. The mind and the brain -- 3. Hierarchy, modularity, and development -- 4. Claims of innate modularity -- 5. The mind and emotions -- 6. A realistic view of evolution, development, and emotions -- 7. Conclusion -- Appendix. Language infinities -- References -- Index.
  • Digital
    Committee on the Diagnostic Criteria for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome, Board on the Health of Select Populations, Institute of Medicine of the National Academies.
    NAP2015
    "Myalgic encephalomyelitis (ME) and chronic fatigue syndrome (CFS) are serious, debilitating conditions that affect millions of people in the United States and around the world. ME/CFS can cause significant impairment and disability. Despite substantial efforts by researchers to better understand ME/CFS, there is no known cause or effective treatment. Diagnosing the disease remains a challenge, and patients often struggle with their illness for years before an identification is made. Some health care providers have been skeptical about the serious physiological - rather than psychological - nature of the illness. Once diagnosed, patients often complain of receiving hostility from their health care provider as well as being subjected to treatment strategies that exacerbate their symptoms. eyond Myalgic Encephalomyelitis/Chronic Fatigue Syndrome proposes new diagnostic clinical criteria for ME/CFS and a new term for the illness - systemic exertion intolerance disease (SEID). According to this report, the term myalgic encephalomyelitis does not accurately describe this illness, and the term chronic fatigue syndrome can result in trivialization and stigmatization for patients afflicted with this illness. Beyond Myalgic Encephalomyelitis/Chronic Fatigue Syndrome stresses that SEID is a medical - not a psychiatric or psychological - illness. This report lists the major symptoms of SEID and recommends a diagnostic process.One of the report's most important conclusions is that a thorough history, physical examination, and targeted work-up are necessary and often sufficient for diagnosis. The new criteria will allow a large percentage of undiagnosed patients to receive an accurate diagnosis and appropriate care. Beyond Myalgic Encephalomyelitis/Chronic Fatigue Syndrome will be a valuable resource to promote the prompt diagnosis of patients with this complex, multisystem, and often devastating disorder; enhance public understanding; and provide a firm foundation for future improvements in diagnosis and treatment"--Publisher's description.
  • Digital
    This book captures the lessons learned from a variety of sectors: multi-sector planning, civil-military coordination, global health, communications, community, animal health, logistics, private sector, and travel and tourist--synthesizing key themes and lessons learned. Based on literature reviews conducted by technical specialists, each chapter identifies the most salient characteristics and lessons learned. Not surprisingly, many cross-cutting themes and lessons learned related to pandemic preparedness emerged.
  • Digital
    Robert J. Thompson.
    OSO2014
    Preface -- 1. American Higher Education in the Twenty-First Century -- 2. Emerging Adulthood: A Developmental Science Perspective -- 3. Personal Epistemology -- 4. Empathy -- 5. Identity and the Process of Self-Authorship -- 6. Campus Culture: Developing the Capacities to Constructively Engage Difference -- 7. Providing a Formative Undergraduate Liberal Education.
  • Print
    edited by Gesa E. Kirsch and Liz Rohan ; with a foreword by Lucille M. Schultz.
    Status: Not Checked OutLane Catalog Record
    Introduction: The role of serendipity, family connections, and cultural memory in historical research / Gesa E. Kirsch and Liz Rohan -- The accidental archivist : embracing chance and confusion in historical scholarship / David Gold -- Being on location : serendipity, place, and archival research / Gesa E. Kirsch -- Getting to know them : concerning research into four early women writers / Christine Mason Sutherland -- Making connections / Alicia Nitecki -- Traces of the familiar : family archives as primary source material / Wendy B. Sharer -- The biography of a graveyard / Ronald R. Stockton -- In a treeless landscape : a research narrative / Kathleen Wider -- My grandfather's trunk / Barry Rohan -- Colonial memory, colonial research : a preamble to a case study / Victor Villanueva -- Unbundling : archival research and Japanese American communal memory of U.S. Justice Department internment, 1941-45 / Gail Y. Okawa -- Mississippi on my mind / W. Ralph Eubanks -- Dreaming Charles Eastman : cultural memory, autobiography, and geography in indigenous rhetorical histories / Malea Powell -- Cultural memory and the lesbian archive / Kate Davy -- "I see dead people" : archive, crypt, and an argument for the researcher's sixth sense / Elizabeth (Betsy) Birmingham -- Stitching and writing a life / Liz Rohan -- When two stories collide, they catch fire / Anca Vlasopolos -- Stumbling in the archives : a tale of two novices / Lisa Mastrangelo and Barbara L'Eplattenier.
  • Digital
    Sharyl J. Nass, Laura A. Levit, and Lawrence O. Gostin, editors ; Committee on Health Research and the Privacy of Health Information, the HIPAA Privacy Rule, Board on Health Sciences Policy, Board on Health Care Services.
    ProQuest Ebook Central2009
    Introduction -- The value and importance of health information privacy -- The value, importance, and oversight of health research -- HIPAA, the privacy rule, and its application to health research -- Effect of the HIPAA privacy rule on health research -- A new framework for protecting privacy in health research.
  • Digital
  • Print
    Status: Not Checked OutLane Catalog Record
  • Digital
    Gandhy Pierre-Louis.
    Epithelial cells sometimes display polarity along the axis orthogonal to the apicobasal axis -- a phenomenon referred to as planar cell polarity (PCP). This polarization biases organization of the cytoskeleton, and is required for a range of fundamental processes including, but not limited to, oriented cell division, polarized function of cilia, and the control of collective cell migration events during development. Consequently, deregulation or dysfunction of PCP genes has been linked to disorders including deafness as a result of misorientation of inner ear cells, neural tube closure defects because of a failure to execute convergent & extension, and tumor invasiveness. Despite having identified some of the key proteins required to achieve PCP, much is still unknown about their molecular functions. Evolutionarily conserved proteins, known as the core PCP proteins, are distributed asymmetrically within wing epithelial cells and form complexes within the proximal or distal cortical domains. Here, we demonstrate that these diametrically opposed complexes participate in a bi-directional negative feedback loop that simultaneously produces their asymmetric distribution within cells and reinforces the orientation of polarity to neighbors by transmitting polarity information intercellularly. We found that one of the core PCP proteins, Prickle (Pk), is important for negative feedback as it is required to mediate the exclusion of distal and proximal complexes from the plasma membrane during acquisition of asymmetry. Moreover, we found that the level of Pk is regulated by the Cullin1 (Cul1)/SkpA/Supernumerary limbs (Slimb) E3 ubiquitin ligase complex. Our observations lead us to believe that loss of, or excess, Pk perturbs PCP signaling through the disruption of feedback. Ultimately, these results highlight an underlying molecular mechanism for the generation of planar polarity. Finally, the approaches presented in this monograph can further help elucidate the molecular functions of the other core PCP proteins.
  • Print
    José Ma. López Piñero [and others].
    tomo 1. Libros y folletos, 1475-1600 -- tomo 2. Libros y folletos, 1601-1700 -- tomo 3. Libros y folletos, 1701-1800 -- tomo 4. Libros y folletos, 1801-1850 -- tomo. 5. Libros y folletos, 1851-1900. ... tomo. 9. Bibliometría de las revistas, 1736-1950.
  • Print
    by Theodore C. Ruch ... with an introduction by John F. Fulton ...
    Status: Not Checked OutLane Catalog Record
    pt. 1. Anatomy, embryology & quantitative morphology; physiology, pharmacology & psychobiology; primate phylogeny & miscellanea.
  • Digital/Print
    Hoff, Ebbe Curtis; Greenbaum, Leon J.
    Digital : Google BooksFulltext (v. 1 1948)
    Digital : Google BooksFulltext (v. 3 1966)
  • Print
    by Harry Hoogstraal ; with the editorial assistance of Anna L. Gahin and Alice Djigounian, and the NAMRU-3 Medical Zoology Department Bibliographic Staff.
    Status: Not Checked OutLane Catalog Record
    v. 1-4. Bibliography of ticks and tickborne diseases from Homer (about 800 B.C.) to 31 December 1969 -- v. 5, pt. I. Bibliography of ticks and tickborne diseases from Homer (about 800 B.C.) to 31 December 1973 -- v. 5, pt. II. Bibliography of ticks and tickborne diseases from Homer (about 800 B.C.) to 31 December 1976 -- v. 7. Bibliography of ticks and tickborne diseases from Homer (about 800 B.C.) to 31 December 1981.
  • Digital/Print
    Center for Minority Group Mental Health Programs.
    Digital : HathiTrust1972
  • Digital/Print
    Digital : HathiTrust1978
  • Print
    Baur, J.
    Volume 1. Journals / compiled by J. Baur ... [et al.].
  • Digital
    edited by Douglas T. Carrell, Catherine Racowsky, Peter N. Schnegel, Bradley J. Van Voorhis.
    Springerv. 1, 2009
  • Digital
    Catherine Racowsky, Peter N. Schlegel, Bart C. Fauser, Douglas T. Carrell, editors.
    Springerv. 2, 2011
    Autoimmunity and Female Infertility: Fact vs. Fiction -- Minimal Stimulation IVF -- Current Understanding of Anti-Müllerian Hormone -- The Role of Obesity in Reproduction -- Endometrial Receptivity in Natural and Controlled Ovarian-Stimulated Cycles -- Current Understanding of Mullerian-Inhibiting Substance -- Evidence-Based Use of Progesterone During IVF -- Monozygotic Twinning and Perinatal Outcomes -- Multiple Pregnancy Vanishing Twin Syndrome -- The Effect of Cancer Therapies on Sperm: Current Guidelines -- Environmental Insults on Spermatogenesis -- Sperm DNA Damage: Causes and Guidelines for Current Clinical Practice -- The Emerging Role of the Sperm Epigenome and its Potential Role in Development -- ART and Epigenetic Disorders: Should We Be Concerned? -- Novel Approaches of Sperm Selection for ART: The Role of Objective Biochemical Markers of Nuclear and Cytoplasmic Integrity and Sperm Function -- The Role of the Oocyte in Remodeling of Male Chromatin and DNA Repair: Are Events During the Zygotic Cell Cycle of Relevance to ART? -- Proteomic/Metabolomic Analysis of Embryos: Current Status for Use in ART -- Ultrasound-Guided Embryo Transfer -- IMSI as a Valuable Tool for Sperm Selection During ART -- Thoughts on IMSI.
  • Digital
    Peter N. Schlegel, Bart C. Fauser, Douglas T. Carrell, Catherine Racowsky, editors.
    Springerv. 3, 2013
    Part I: Male Infertility -- 1. Supplements to Enhance Male Fertility / Peter N. Schlegel -- 2. Poor Quality Ejaculate Sperm: Do the Data Support the Use of Testis Sperm? / Robert D. Oates -- 3. The Aging Male and Impact on Offspring / Timothy G. Jenkins, Kenneth I. Aston, and Douglas T. Carrell -- 4. Testosterone Replacement Therapy in Men: Effects on Fertility and Health / Peter T.K. Chan -- Part II: Female Infertility -- 5. A Practical Approach to Recent Advancesin Ovarian Reserve Testing / Benjamin Leader and Valerie L. Baker -- 6. Maternal Age and Oocyte Aneuploidy: Lessons Learned from Trisomy 21 / Stephanie L. Sherman, Emily G. Allen, and Lora J.H. Bean1 -- 7. Fertility Preservation for Cancer Patients / Suneeta Senapati and Clarisa R. Gracia -- 8. Reproductive Surgery and Computer-Assisted Laparoscopy: The New Age of Subspecialty Surgery Is Here / Shane T. Lipskind and Antonio R. Gargiulo -- Part III: Assisted Reproduction Techniques -- 9. Advances in Systems for Embryo Culture / Roberta Maggiulli, Lisa Dovere, Filippo Ubaldi and Laura Rienzi -- 10. Patient-Tailored Approaches to Ovarian Stimulation in ART / Theodora C. van Tilborg, Frank J.M. Broekmans, Helen L. Torrance and Bart C. Fauser -- 11. Cryopreserved Oocyte Banking: Its Prospects and Promise / Kathryn J. Go, Zsolt Peter Nagy, and Ching-Chien Chang -- 12. Reproductive Tourism / Raphael Ron-El -- Part IV: Evolving Controversies in Contemporary Reproductive Medicine -- 13. Intrauterine Insemination: An Ineffective Treatment / Erica B. Johnstone and Jessie Dorais -- 14. IUI Is a Valuable and Cost-Effective Therapy for Most Couples / Lobke M. Moolenaar, Bradley J. Van Voorhis and Fulco van der Veens -- 15. Vitrification of Human Oocytes and Embryos: An Overview / Juergen Liebermann -- 16. Should We Eliminate Fresh Embryo Transfer from ART? / Daniel J. Kaser, Maria Assens, and Catherine Racowsky -- 17. ICSI Is a Revolutionary Treatment of Male Infertility That Should Be Employed Discriminately and Further Studied / Douglas T. Carrell -- 18. The Need for Long-Term Follow-Up of Children Conceived Through ICSI / Rachel Weinerman, Kurt T. Barnhart, and Suleena Kansal Kalra -- 19. Popularity of ICSI / Gianpiero D. Palermo, Queenie V. Neri, Trina Fields and Zev Rosenwaks -- Part V: Clinical Research Design -- Cohort Designs: Critical Considerations for Reproductive Health.
  • Digital
    Douglas T. Carrell, Peter N. Schlegel, Catherine Racowsky, Luca Gianaroli.
    Springer2015
    Now in its fourth volume, the Biennial Review of Infertility brings together the most up-to-date research and clinical information on male and female infertility, emerging assisted reproductive techniques and evolving controversies in reproductive medicine. An impressive panel of contributors presents cutting-edge information in a clear and well-balanced manner. Volume 4 discusses hot topics in contemporary reproductive medicine, including stem cell technologies for male infertility, the current state of ovarian tissue cryopreservation and time-lapse video microscopy of embryos. The expanded section on controversies allows for point/counterpoint discussion between experts with differing opinions on topics like eSET and the use and role of dietary supplements in IVF cycles. Created to provide an ongoing appraisal of current knowledge, the Biennial Review of Infertility stimulates communication amongst all clinicians and researchers working to help couples resolve their infertility.
  • Digital
    edited by Ron Waksman and John A. Ormiston.
    Wiley2012
    Bifurcation classifications / V. Legrand -- Provisional / T. Lefevre -- The Nordic experience / J.F. Lassen -- Crush & mini-crush / J.R. Galassi [and others] -- Simultaneous kissing stent (SKS) technique : a contemporary review / S.K. Sharma & J. Sweeny -- Stenting for left main coronary artery bifurcation lesions / S.J Park & Younh-Hak Park -- IVUS & new imaging / S.J Park -- Drug-eluting balloons and bifurcations, a new future? / Pieter Stella [and others] -- Percutaneous coronary intervention for bifurcation lesions : bench testing and the real world / J. Ormiston, Mark Webster & Bruce Webber -- Bifurcation & stent thrombosis / Ron Waksman & Michael Mahmoudi -- Bifurcation angles during the cardiac cycle : the role of 4-dimensional detection of coronary bifurcation by MDCT / M.A. Costa [and others] -- OCT in coronary bifurcations / Evelyn Regar [and others] -- Bifurcation quantitative coronary angiography / A.J. Lansky, Vivan Ng -- Evaluation of a dedicated everolimus coated side branch access (SBA) system -- W.J. van der Giessen [and others] -- Trireme / A. Abizaid and Ricardo Costa -- Petal stent / J. Ormiston, Frederic De Vroey, Mark Webster -- The sideguard sidebranch stent / Eberhard Grube -- XIENCETM side branch access system for the treatment of bifurcation lesions (XIENCE SBA) / David Rizik & Gary Idelchik -- The spherical balloon : a new PTCA balloon to optimize provisional side branch T stenting technique in coronary bifurcation treatment / Remo Albiero -- AXXESS stent / S. Verheye & Brett Trauthen.
  • Print
    Viktor Mayer-Schönberger and Kenneth Cukier.
    Explores the idea of big data, which refers to our newfound ability to crunch vast amounts of information, analyze it instantly, and draw profound and surprising conclusions from it.
  • Digital
    written and edited by Lee W. Janson, Marc E. Tischler.
    AccessMedicine2012 [2018 update]
    Section I. The Basic Molecules of Life -- 1. Amino acids and proteins -- 2. Carbohydrates -- 3. Lipids -- 4. Nucleosides, nucleotides -- Section II. Functional biochemistry -- 5. Enzymes and amino acid metabolism -- 6. Carbohydrate metabolism -- 7. Lipid metabolism -- 8. Membranes -- 9. DNA/RNA function and protein synthesis -- Section III. Applied biochemistry -- 10. Metabolism and vitamins/minerals / Maria L. Valencik and Cynthia C. Mastick -- 11. The Digestive system / Kshama Jaiswal -- 12. Muscles and cell motility / Darren Campbell -- 13. Connective tissue and bone / Jacques Kerr -- 14. Blood / Matthew Porteus -- 15. The Immune system / Eric L. Greidinger, Leonard M. Miller -- 16. The Cardiovascular system / Ralph Shohet, John A. Burns -- 17. The respiratory system / Howard Huang -- 18. The Urinary system / Armando J. Lorenzo -- 19. The Nervous system / Kathryn Beck-Yoo -- 20. The Reproductive system / Catrina Bubier -- Section IV. Appendices -- Appendix I. Biochemical Basis of Diseases -- Appendix II. Biochemical Methods -- Appendix III. Organic Chemistry Primer.
  • Digital/Print
    [edited by] Giuseppe Borzellino, Claudio Cordiano.
    Digital : Springer2008
    Print2008
  • Digital
    edited by Joseph M. Herman, Timothy M. Pawlik, Charles R. Thomas, Jr.
    Springer2014
    The second edition of this book is intended as a definitive text on biliary tract and gallbladder cancers. Specifically, it will serve as a single-source reference on the current knowledge base for the multidisciplinary management of such cancers and thus covers epidemiological, surgical, radiotherapy, and chemotherapy approaches. Akey feature is the demonstration of the impact of cutting-edge technical knowledge on treatment; for example, interventional radiology techniques, novel surgical approaches, and image-guided radiation therapy are all extensively discussed. Diagnosis is also considered in detail, with coverage of novel serum biomarkers, pathologic staging, molecular profiling, and the full range of current and emerging imaging strategies. Further chapters are devoted to epidemiology, the role of growth factor pathways and signal transduction, and histopathology and molecular pathogenesis. Experienced practitioners in a range of specialties will find this amply illustrated book to be an invaluable source of information on the newest diagnostic and treatment techniques in biliary tract and gallbladder cancer, yet it is also sufficiently concise to offer an introduction to the field for students and community practitioners.
  • Digital/Print
    edited by Maria Teresa Giardi, Giuseppina Rea, Bruno Berra.
    Digital : Springer2010
    Print2010
    The Nutra-Snacks project : basic research and biotechnological programs on nutraceutics / Giuseppina Rea ... [et al.] -- Overview of diet-gene interactions and the example of xanthophylls / Barbara Demmig-Adams and William W. Adams III -- Therapeutic potential of dietary polyphenols against brain ageing and neurodegenerative disorders / Giovanni Scapagnini, Calogero Caruso, and Vittorio Calabrese -- Plant phenolics in the prevention and treatment of cancer / Klaus W.J. Wahle ... [et al.] -- Endogenous antioxidants and radical scavengers / Angela Maria Rizzo ... [et al.] -- A nutritional strategy for reducing disease and obesity risks / Teresa Lavecchia ... [et al.] -- Dietary phytochemicals and human health / Justyna Krzyzanowska, Anna Czubacka, and Wieslaw Oleszek -- Bioactive compounds from northern plants / Anja Hohtola -- Nutraceutical use of garlic sulfur-containing compounds / Eleftherios Touloupakis and Demetrios F. Ghanotakis -- Genetic engineering to enhance crop-based phytonutrients (nutraceuticals) to alleviate diet-related diseases / Autar K. Mattoo ... [et al.] -- Perspective for the use of genetic transformants in order to enhance the synthesis of the desired metabolites : engineering chloroplasts of microalgae for the production of bioactive compounds / Udo Johanningmeier and Dirk Fischer -- Biological elicitors of plant secondary metabolites : mode of action and use in the production of nutraceutics / Simone Ferrari -- Hairy root cultures for secondary metabolites production / Laura Pistelli ... [et al.] -- Plant tissue culture : an opportunity for the production of nutraceuticals / Mariella Lucchesini and Anna Mensuali-Sodi -- Plant cell cultures : bioreactors for industrial production / Barbara Ruffoni ... [et al.] -- Determination of the antioxidants' ability to scavenge free radicals using biosensors / Montserrat Cortina-Puig ... [et al.] -- Biosensors for the determination of phenolic metabolites / Simona Carmen Litescu, Sandra Eremia, and Gabriel Lucian Radu -- Methods for the determination of antioxidant capacity in food and raw materials / Simona Carmen Litescu, Sandra Eremia, and Gabriel Lucian Radu -- Analytical methods for the extraction and identification of secondary metabolite production in 'in vitro' plant cell cultures / Alessandra Bertoli ... [et al.] -- Biosensors for functional food safety and analysis / Teresa Lavecchia, Arianna Tibuzzi, and Maria Teresa Giardi -- Biosensors for secondary metabolites, two case studies : ochratoxin A and microcystin / Monica Campàs, Beatriz Prieto-Simón And Régis Rouillon -- Biosensors as analytical tools in food fermentation industry / Lise Barthelmebs ... [et al.] -- An overview of the functional food market : from marketing issues and commercial players to future demand from life in space / Francesca Vergari, Arianna Tibuzzi, and Giovanni Basile -- Legislation on nutraceuticals and food supplements a comparison between regulations in USA and EU / Roberto Giunta, Giovanni Basile, and Arianna Tibuzzi.
  • Digital
    [edited by] Julian Jones and Alexis G. Clare.
    Wiley2012
    The unique nature of glass / Alexis G. Clare -- Melt derived bioactive glass / Matthew D. O'Donnell -- Sol-gel derived glasses for medicine / Julian R. Jones -- Phosphate glasses / Delia S. Brauer -- The structure of bioactive glasses and their surfaces / Alastair N. Cormack -- Bioactive borate glasses / Steven B. Jung -- Glass-ceramics / Wolfram H'land -- Bioactive glass- and glass-ceramic coatings / Enrica Vern -- Composites containing bioactive glass / Aldo R. Boccaccini and Qi-Zhi Chen -- Inorganic-organic sol-gel hybrids / Yuki Shirosaki [and others] -- Dental applications of glasses / Leena Hupa and Antti Yli-Urpo -- Bioactive glass as synthetic bone grafts and scaffolds for tissue engineering / Julian R. Jones -- Glasses for radiotherapy / Delbert E. Day.
  • Print
    Dario Floreano, Claudio Mattiussi.
  • Digital
    Salomon Joseph Trujillo.
    The priorities of a climbing legged robot are to maintain a grasp on its climbing surface and to climb efficiently against the force of gravity. Climbing robots are especially susceptible to thermal overload during normal operation, due to the need to oppose gravity and to frequently apply internal forces for clinging. These priorities guided us to develop optimal climbing behaviors under thermal constraints. These behaviors in turn profoundly constrain the choice of gait regulation methods. We propose a novel algorithm: "travel-based" gait regulation that varies foot detachment timing, effectively modifying stride length and frequency in order to maintain gait phasing, subject to kinematic and stability constraints. A core feature of the algorithm is "travel, " a new metric that plays a similar role to relative phasing. The method results in linear equations in terms of travel, leading to straightforward tests for local and global convergence when, for example, disturbances such as foot slippage cause departures from the nominal phasing. We form recurrence maps and use eigenvalue and singular value decomposition to examine local convergence of gaits. To examine global convergence, we implemented a computational geometry technique in high-order spaces. Our travel-based algorithm benefits from a compact code size and ease of implementation. We implemented the algorithm on the RiSE and Stickybot III robots as well as a virtual hexapod in a physics simulator. We demonstrated quickly converging gaits on all platforms as well as gait transitions on Stickybot III and the virtual hexapod.
  • Digital
    edited by Anthony B. Brennan, Chelsea M. Kirschner.
    Wiley2014
    ECM-inspired chemical cues : biomimetic molecules and techniques of immobilization / Roger Y. Tam, Shawn C. Owen and Molly S. Shoichet -- Dynamic materials mimic developmental and disease changes in tissues / Matthew G. Ondeck and Adam J. Engler -- The role of mechanical cues in regulating cellular activities and guiding tissue development / Liming Bian -- Contribution of physical forces to the design of biomimetic tissue substitutes / M. Ermis, E.T. Baran, T. Dursun, E. Antmen and V. Hasirci -- Cellular responses to engineered bio-inspired topographic cues / Chelsea M. Kirschner, James F. Schumacher and Anthony B. Brennan -- Engineering the mechanical and growth factor signaling roles of fibronectin fibrils / Christopher A. Lemmon -- Biologic scaffolds composed of extracellular matrix as a natural material for wound healing / Stephen Badylak -- Bio-inspired integration of natural materials / Albino Martins, Marta Alves da Silva, Ana Costa-Pinto, Rui L. Reis and Nuno M. Neves -- Bio-inspired design of skin replacement therapies / Dennis P. Orgill -- Epithelial engineering: from sheets to branched tubes / Hye Young Kim and Celeste M. Nelson -- A biomimetic approach toward the fabrication of epithelial-like tissue / Meng Xu and Hongjun Wang -- Nano- and micro-structured ECM and biomimetic scaffolds for cardiac tissue engineering / Quentin Jallerat, John M. Szymanski and Adam W. Feinberg -- Cardiovascular biomaterials / Elaine L. Lee and Joyce Y. Wong -- Evaluation of bio-inspired materials for mineralized tissue regeneration using type I collagen reporter cells / Lisa T. Kuhn, Emily Jacobs, and A. Jon Goldberg -- Learning from tissue equivalents : biomechanics and mechanobiology / David D. Simon and Jay D. Humphrey -- Mimicking the hematopoietic stem cell niche by biomaterials approaches / Eike Müller, Michael Ansorge, Carsten Werner and Tilo Pompe -- Engineering immune responses to allografts / Anthony W. Frei and Cherie L. Stabler -- Immunomimetic materials / Jamal S. Lewis and Benjamin G. Keselowsky.
  • Digital
    Naomi Kato, Shinji Kamimura, eds.
    Springer2008
    Biological aspects of locomotive mechanisms and behaviors of animals while swimming and flying -- Hydrodynamics of swimming and flying -- Biomimetic swimming or flying robots -- Sports science.
  • Digital
    edited by Vladimir Uversky, Yuri Lyubchenko.
    ScienceDirect2014
    Bio-Nanoimaging: Protein Misfolding & Aggregation provides a unique introduction to both novel and established nanoimaging techniques for visualization and characterization of misfolded and aggregated protein species. The book is divided into three sections covering: - Nanotechnology and nanoimaging technology, including cryoelectron microscopy of beta(2)-microglobulin, studying amyloidogensis by FRET; and scanning tunneling microscopy of protein deposits - Polymorphisms of protein misfolded and aggregated species, including fibrillar polymorphism, amyloid-like protofibrils, and insulin olig.
  • Digital
    edited by Debasis Bagchi, Manashi Bagchi, Hiroyoshi Moriyama, Fereidoon Shahidi.
    Wiley2013
    Nanotechnology / Hiroshi Muramatsu, Jun'ichi Wakayama, Kazumi Tsukamoto, Shigeru Sugiyama -- Applications of NMR to Biomolecular Systems of Interactions: An Overview / Shinya Hanashima, Yoshiki Yamaguchi -- Applications in Enhancing bioavailability and Controlling Pathogens. Bioavailability and Delivery of Nutraceuticals and Functional Foods Using Nanotechnology / Hailong Yu, Qingrong Huang -- Encapsulation of Bioactive Compounds in Micron/Submicron-Sized Dispersions Using Microchannel Emulsification or High-Pressure Homogenization / Marcos A Neves, Isao Kobayashi, Henelyta S Ribeiro, Katerina B Fujiu -- Nanometric-Size Delivery Systems for Bioactive Compounds for the Nutraceutical and Food Industries / Francesco Donsi, Mariarenata Sessa, Giovanna Ferrari -- Nanoemulsion Technology for Delivery of Nutraceuticals and Functional-Food Ingredients / Luz Sanguansri, Christine M Oliver, Fernando Leal-Calderon -- Nanotechnology and Nonpolar Active Compounds in Functional Foods: An Application Note / Philip J Bromley -- Safety, Toxicology and Regulatory Aspects. How Standards Inform the Regulation of Bio-nanotechnology / Martha E Marrapese -- FDA and Nanotech: Baby Steps Lead to Regulatory Uncertainty / Raj Bawa -- Toxicity and Environmental Risks of Nanomaterials: An Update / Paresh C Ray, Anant Kumar Singh, Dulal Senapati, Zhen Fan, Hongtao Yu -- Nanoparticle-Lung Interactions and Their Potential Consequences for Human Health / Craig A Poland, Martin J D Clift -- Future Directions in Bio-Nanotechnology Bio-Nanotechnology: A Journey Back to the Future / Debasis Bagchi, Manashi Bagchi, Hiroyoshi Moriyama, Fereidoon Shahidi.
  • Digital
    edited by Om V. Singh.
    Wiley2017
    "Provide the insights of bio-pigmentation and molecular mechanisms of microbial biosynthesis of pigments. The new avenues of bio-pigments as sustainable resources to overcome from chemically synthesized pigments under safety net will be established"--Provided by publisher.
  • Print
    edited by Zsuzsanna Bösze.
  • Digital
    edited by John A. Milner, Donato F. Romagnolo ; forewords by David S. Alberts, Maria Lluria-Prevatt, Scott M. Lippman.
    Springer2010
    Monitoring the burden of cancer in the United States -- Cancer biology and nutrigenomics -- Cellular cancer processes and their molecular targets -- Nutrigenetics: the relevance of polymorphisms -- Diet and epigenetics -- Nutrient signaling-protein kinase to transcriptional activation -- Dietary energy balance, calorie restriction, and cancer prevention -- Fiber and microbially generated active components -- Gut microbiota, probiotics, prebiotics and colorectal cancer -- Meats, protein and cancer -- Saturated fatty acids and cancer -- Conjugated linoleic acid and cancer -- Cancer and n-3PUFAs: the translational connection -- n-6 polyunsaturated fatty acids and cancer -- Carotenoids -- Vitamin A -- Vitamin D and cancer chemoprevention -- Folate -- Selenium -- Calcium and cancer -- Iron and cancer -- Zinc in cancer development and prevention -- Cruciferous vegetables, isothiocyanates, indoles, and cancer prevention -- Garlic and cancer prevention -- Mammary and prostate cancer chemoprevention and mechanisms of action of resveratrol and genistein in rodent models -- Cancer prevention by catechins, flavonols, and procyanidins -- Mechanisms of action of isoflavones in cancer prevention -- The anticarcinogenic properties of culinary herbs and spices -- Cancer prevention with berries: role of athocyanins -- Pomegranate -- Alcohol and cancer: biological basis -- Aryl hydrocarbon receptor-mediated carcinogenesis and modulation by dietary xenobiotic and natural ligands -- Opportunities and challenges for communicating food and health relationships to American consumers.
  • Digital
    Blanca Hernandez-Ledesma and Miguel Herrero.
    Wiley2014
  • Digital
    Ronald Ross Watson, Sherma Zibadi, editors.
    Springer2013
    The role of Bioactive Dietary Factors and Plant Extracts in Preventive Dermatology provides current and concise scientific appraisal of the efficacy of foods, nutrients, herbs, and dietary supplements in preventing dermal damage and cancer as well as improving skin health. This important new volume reviews and presents new hypotheses and conclusions on the effects of different bioactive foods and their components derived particularly from vegetables, fruits, and herbs. Primary emphasis is on treatment and prevention of dermal damage focusing on skin cancers with significant health care costs and mortality. Bioactive Dietary Factors and Plant Extracts in Preventive Dermatology brings together expert clinicians and researchers working on the different aspects of supplementation, foods, and plant extracts and nutrition and skin health. Their expertise provides the most current knowledge in the field and will serve as the foundation for advancing future research.
  • Digital/Print
    Feridoun Karimi-Busheri, editor.
    Digital : Springer2015
    Print2015
    1. Integration, networking, and global biobanking in the age of new biology -- 2. The future of biobanking: a conceptual look at how biobanks can respond to the growing human biospecimen needs of researchers -- 3. Sustainability of biobanks in the future -- 4. Biobanking: the future of cell preservation strategies -- 5. Biobanking for personalized medicine -- 6. A global view of breast tissue banking -- 7. Biobanking of cerebrospinal fluid for biomarker analysis in neurological diseases -- 8. Biobanking in the twenty-first century: driving population metrics into biobanking quality -- 9. Challenges in developing a cancer oriented-biobank: experience from a 17 year-old cancer biobank in Sao Paulo, Brazil -- 10. China biobanking -- 11. Establishing an iso-compliant modern cancer-biobank in a developing country: a model for international cooperation -- 12. Nursing and biobanking -- 13. A data-centric strategy for modern biobanking -- 14. The importance of quality patient advocacy to biobanks: a lay perspective from Independent Cancer Patients Voice (ICPV), based in United Kingdom -- Index.
  • Digital
    Christian Lenk, Judit Sándor, Bert Gordijn, editors.
    Springer2011
    Pt. I. Biobanks, tissue research and the public. Public trust and public bodies : the regulation of the use of human tissue for research in the United Kingdom / Julie Kent, Ruud ter Meulen -- Biobanks and research : scientific potential and regulatory challenge / Bernice S. Elger, Nikola Biller-Andorno -- A sense of entitlement : individual vs. public interest in human tissue / Nils Hoppe -- Social aspects of biobanking : beyond the public/private distinction and inside the relationship between the body and identity / Federico Neresini -- Pt. II. The rights of donors and patients. One sample, one share! A proposal to redress an inequity with equity / Jasper Adriaan Bovenberg -- Research on human biological materials : what consent is needed, and when / Eugenijus Gefenas, Vilius Dranseika, Asta Cekanauskaite, Jurate Serepkaite -- Reconsidering consent and biobanking / Emma Bullock, Heather Widdows -- What's wrong with forensic uses of biobanks? / Claudio Tamburrini -- Pt. III. Regulation of tissue research. A unified European approach on tissue research and biobanking? A comparison / Katharina Beier, Christian Lenk -- Ireland and the United Kingdom's approaches to regulation of research involving human tissue / Elizabeth Yuko, Adam McAuley, Bert Gordijn -- Legal and ethical aspects of biobanks for research in the European-Mediterranean area / Renzo Pegoraro, Allesandra Bernardi, Fabrizio Turoldo -- The circulation of human body parts and products : when exclusive property rights mask the issue of access / Florence Bellivier, Christine Noiville -- Anonymity and privacy in biobanking / Judit Sándor, Petra Bárd.
  • Digital
    Amy Rosenberg, Barthélemy Demeule, editors.
    Springer2015
  • Digital
    Robert B. Heimann and Hans D. Lehmann.
    Wiley2015
  • Digital
    Oscar John Abilez.
    Cardiovascular disease affects more than 70 million Americans and is the number one cause of mortality in the United States. Because the regenerative capacity of cardiac tissue is limited, human pluripotent stem cells (hPSC) have emerged as a potential source for cellular-based therapies. However, for these therapies to be effective, sufficient amounts of differentiated cells must be produced, these cells must be identified and sorted, and, upon implantation, arrhythmias must be avoided. In this dissertation, I describe the biochemical control of hPSC for their directed differentiation into cardiomyocytes, electrical control for electrophysiology-based cell sorting, and optogenetic control for temporal synchronization. For future therapy, the in vivo application of optical stimulation could allow immediate, precise, and specific synchronization of efficiently derived and purified hPSC-CM with patient cardiac rates and rhythms. This, in turn, would significantly reduce the chance of arrhythmias arising from implanted hPSC-CM, and, therefore, contribute towards establishing a safe and effective cell-based therapy.
  • Digital
    Jawahar L. Mehta, Naranjan S. Dhalla, editors.
    Springer2013
    Angiogenesis plays a key role in human physiology and pathophysiology. While necessary for tissue growth and development, uncontrolled angiogenesis plays a role in the progression of certain tumors as well as atherosclerosis. Lack of angiogenesis may be the basis of myocardial ischemia and stroke. Knowledge on the mechanisms of angiogenesis is growing very rapidly, and may lead to important drugs for therapy of a variety of clinical disorders. Experts from around the world have contributed a vast array of data on different aspects of angiogenesis in this volume edited by Professors Mehta and Dhalla. This information will be of immense help to basic scientists, clinicians and those involved in drug development.
  • Digital/Print
    Abhijit Chakrabarti.
    Digital : Springer2015
    Print2015
    Consists of critical reviews and original research papers from the 2014 International Symposium on the "Biochemical Role of Eukaryotic Cell Surface Macromolecules". Topics covered include: · neurochemical and biochemical analysis of cell surface glycoconjugates · membrane skeletal organization · GPCRs and other receptors · biophysical approaches to study membrane interactions · glycoconjugate metabolism · dysregulation · molecular mechanisms involved in cell-cell and cell-matrix interaction · glycans in infectious and neurological diseases · cancer and glycosyltransferases as drug targets.
  • Digital/Print
    Perumana R. Sudhakaran, Avadhesha Surolia, editors.
    Digital : Springer2012
    Print2012
    Glycomics: An Overview of the Complex Glycocode / Garima Gupta and Avadhesha Surolia -- Structural Glycomic Approaches to Molecular Recognition Events on Cell Surfaces / Koichi Kato -- ISCSM2011 Chondroitin Sulfate E-type Structure at Tumor Cell Surface Is Involved in Experimental Metastasis / Kazuyuki Sugahara and Shuji Mizumoto -- Chondroitin Sulfate-Specific Novel Hydrolase in Human / Shuhei Yamada -- Identification of Endothelial Cell Surface Carbohydrate-Binding Receptors by Carbohydrate Ligand Mimicry Peptides / Michiko N. Fukuda -- Lysosomal Enzyme Sorting Receptors - Where Did They First Appear in the Animal Kingdom? / Suryanarayanaraju Vegiraju, Suresh Koduru and Siva Kumar Nadimpalli -- Endoplasmic Reticulum-Targeted Bcl-2 Inhibitable Mitochondrial Fragmentation Initiates ER Stress-Induced Cell Death / B. C. Bhavya, Deepa Indira, Mahendra Seervi, Jeena Joseph and Praveen K. Sobhan, et al. -- Interactions Between Caveolin-1 and Sphingolipids, and Their Functional Relevance / Sandro Sonnino, Simona Prioni, Vanna Chigorno and Alessandro Prinetti -- Cell Membrane Repair Pathway Involves Sensing of Dynamics of Caveolae and Caspase-1 / Saumya S. Srivastava and M. V. Krishnasastry -- Angiogenic Response of Endothelial Cells to Fibronectin / V. B. S. Kumar, R. I. Viji, M. S. Kiran and Perumana R. Sudhakaran -- Lactosylceramide Synthase as a Therapeutic Target to Mitigate Multiple Human Diseases in Animal Models / Subroto Chatterjee and Nezar Alsaeedi -- Advanced FRET Methodologies: Protein-Lipid Selectivity Detection and Quantification / Fábio Fernandes, Manuel Prieto and Luís M. S. Loura -- Mechanism of GPCR-Directed Autoantibodies in Diseases / Hamiyet Unal, Rajaganapathi Jagannathan and Sadashiva S. Karnik -- Role of Membrane Cholesterol in Leishmanial Infection / Amitabha Chattopadhyay and Md. Jafurulla -- How Intact Is the Basement Membrane? Role of MMPs / S. Asha Nair, Sankar Jagadeeshan, Ramachandran Indu, Perumana R. Sudhakaran and M. R. Pillai -- Apoptosis of Breast Cancer Cells: Modulation of Genes for Glycoconjugate Biosynthesis and Targeted Drug Delivery / Subhash Basu, Rui Ma, Joseph R. Moskal, Manju Basu and Sipra Banerjee -- Altered Expression of Sialidases in Human Cancer / Taeko Miyagi, K. Takahashi, S. Moriya, K. Hata and K. Yamamoto, et al. -- Poly-ADP-Ribosylation of Vascular Endothelial Growth Factor and Its Implications on Angiogenesis / S. Binu, S. J. Soumya, V. B. S. Kumar and Perumana R. Sudhakaran -- Sphingolipid-Binding Domain in the Serotonin1A Receptor / Amitabha Chattopadhyay, Yamuna Devi Paila, Sandeep Shrivastava, Shrish Tiwari and Pushpendra Singh, et al. -- Withanolide D, Carrying the Baton of Indian Rasayana Herb as a Lead Candidate of Antileukemic Agent in Modern Medicine / Susmita Mondal, Saptarshi Roy, Rita Maity, Asish Mallick and Rajender Sangwan, et al. -- Engineered Glucose to Generate a Spectroscopic Probe for Studying Carbohydrate Biology / Ashish Tripathi, Vibha Singh, K. G. Aishwarya, Gopala Krishna Aradhyam and Srinivas Hotha -- Changes in Sialic Acid Content of Jelly Coat in Pesticide-Exposed Frog Eggs and Their Influence on Fertilization / H. P. Gurushankara, S. V. Krishnamurthy and V. Vasudev.
  • Digital/Print
    Jeremy M. Berg, John L. Tymoczko, Lubert Stryer ; Web content by Neil D. Clarke.
    Digital : NCBI Bookshelf2002
    Print2002
  • Print
    Todd A. Swanson, Sandra I. Kim, Marc J. Glucksman.
    Status: Not Checked OutLane Catalog Record
  • Print
    John W. Pelley, Edward F. Goljan.
    Status: Not Checked OutLane Catalog Record
    Carbohydrates, lipids, and amino acids : metabolic fuels and biosynthetic precursors -- Proteins and enzymes -- Membrane biochemistry and signal transduction -- Nutrition -- Generation of energy from dietary fuels -- Carbohydrate metabolism -- Lipid metabolism -- Nitrogen metabolism -- Integration of metabolism -- Nucleotide synthesis and metabolism -- Organization, synthesis, and repair of DNA -- Gene expression -- DNA technology -- Common laboratory values.
  • Print
    David E. Metzler ; in association with Carol M. Metzler ; designed and illustrated by David J. Sauke.
    Status: Not Checked OutLane Catalog Record
  • Print
    Golder N. Wilson.
    Status: Not Checked OutLane Catalog Record
    High Yield Facts -- DNA Structure, Replication and Repair -- Gene Expression and Regulation -- Acid-base equilibria, amino acids, and protein structure -- Protein Structure/Function -- Carbohydrate Metabolism -- Bioenergetics and Energy Metabolism -- Lipid, Amino Acid and Nucleotide Metabolism -- Vitamins and Minerals -- Hormones and Integrated Metabolism -- Inheritance Mechanisms/Risk Calculations -- Genetic and Biochemical Diagnosis.
  • Print
    Golder N. Wilson ; cytogenetic contribution by Vijay Tonk.
    Status: Not Checked OutLane Catalog Record
  • Digital
    Tsugikazu Komoda, Toshiyuki Matsunaga.
    ScienceDirect2015
  • Digital/Print
    edited by Dennis E. Vance and Jean E. Vance.
    Digital : ScienceDirect2008
    Print2008
    Functional roles of lipids in membranes / William Dowhan, Mikhail Bogdanov, and Eugenia Mileykovskaya -- Lipid modifications of proteins / Anant K. Menon -- Fatty acid and phospholipid metabolism in prokaryotes / Charles O. Rock -- Lipid metabolism in plants / Katherine M. Schmid and John B. Ohlrogge -- Oxidation of fatty acids in eukaryotes / Horst Schulz -- Fatty acid synthesis in eukaryotes / Hei Sook Sul and Stuart Smith -- Fatty acid desaturation and chain elongation in mammals / Makoto Miyazaki and James N. Ntambi -- Phospholipid biosynthesis in eukaryotes / Dennis E. Vance and Jean E. Vance -- Ether-linked lipids and their bioactive species / Thomas M. McIntyre, Fred Snyder, and Gopal K. Marathe -- Lipid metabolism in adipose tissue / Ann V. Hertzel ... [et al.] -- Phospholipases / David C. Wilton -- The eicosanoids : cyclooxygenase, lipoxygenase, and epoxygenase pathways / William L. Smith and Robert C. Murphy -- Sphingolipids / Alfred H. Merrill, Jr. -- Cholesterol biosynthesis / Laura Liscum -- Metabolism and function of bile acids / Luis B. Agellon -- Lipid assembly into cell membranes / Dennis R. Voelker -- Lipoprotein structure / Ana Jonas and Michael C. Phillips -- Assembly and secretion of triacylglycerol-rich lipoproteins / Jean E. Vance and Khosrow Adeli -- Dynamics of lipoprotein transport in the circulatory system / Christopher J. Fielding and Phoebe E. Fielding -- Lipoprotein receptors / Wolfgang J. Schneider -- Lipids and atherosclerosis / Ira Tabas.
  • Digital
    Ricardo Jorge Gelpi, Alberto Boveris, Juan José Poderoso, editors.
    Springer2016
    Introduction -- Section 1 GENERAL ASPECTS: 1 The concept of oxidative stress after 30 years -- 2 Evolution of atmospheric oxygen and oxygen metabolism -- 3 Mitochondria as origin of cellular oxidative stress -- 4 Biochemistry and physiology of mtNOS -- 5 Biochemistry of nitrogen reactive species -- 6 Biochemistry of nitro fatty acids -- 7 Mammalian adaptation to life at high altitude -- 8 Metabolic syndrome and oxidative stress in rat pancreas -- 9 Progesterone prevents mitochondrial dysfunction and oxidative stress in the spinal cord of wobbler mice -- 10 Mitochondrial transfer by intercellular nanotubes -- Section 2 CARDIOVASCULAR: 11 Role of Oxidative Stress in Subcellular Defects in Ischemic Heart Disease -- 12 Regulation of protein nitrosylation by Trx1 -- 13 Inhibition of adenylyl cyclase type 5 increases longevity and healthful aging through oxidative stress protection -- 14 Antioxidant supplementation in elderly cardiovascular patients -- 15 Rupture of redox homeostasis in a model of pulmonary artery -- 16 Mitochondrial reactive oxygen species triggered by the cardiac renin-angiotensin-aldosterone system -- 17 Mitochondrial complex I inactivation and increased autooxidation after ischemia-reperfusion in the stunned heart -- 18 Oxidized LDL and atherogenesis -- 19 Reactive oxygen species and cyclooxygenase products in the regulation of blood flow in small vessels -- 20 Thioredoxin-1 attenuates postischemic ventricular and mitochondrial dysfunctions -- 21 Nitro-arachidonic acid reduces the damaged area in rat myocardial infarction -- 22 Inhaled particulate matter and myocardial dysfunction -- Section 3 NEURODEGENERATION AND NEURONAL FUNCTION: 23 Effect of lipoic acid in the triple transgenic mouse model of Alzhaimer's disease -- 24 Neurovascular coupling mediated by NO in the hippocampus -- 25 Protection from neurodegeneration: signaling and mitocondrial regulation -- 26 Oxidative stress and neurodegeneration -- 27 Oxidative stress, metabolic syndrome and Alzheimerþs disease -- 28 Systemic oxidative stress in patients with neurodegenerative diseases -- Section 4 CANCER: 29 Oxygen metabolism and oxidative stress in cancer cells -- 30 Mitochondrial biogenesis is required for survival and propagation of cancer cells -- 31 Tumor immunology & immunotherapy in patients -- 32 Oncogene-induced Nrf2 repression as adaptive response of cancer cells to acquire a pro-oxidant state favoring cell survival and in vivo tumor growth -- 33 Mitochondrial dynamics regulate oxidative metabolism in Leydig tumor cells -- Index.
  • Digital
    Mary Ann Asson-Batres, Cécile Rochette-Egly, editors.
    Springer2014
    A role for vitamin A in living organisms has been known throughout human history. In the last 100 years, the biochemical nature of vitamin A and its active derivative, retinoic acid, its physiological impact on growth processes and the essential details of its mechanism of action have been revealed by investigations carried out by researchers using vertebrate and more recently invertebrate models to study a multiplicity of processes and conditions, encompassing embryogenesis, postnatal development to old age. A wealth of intercellular interactions, intracellular signaling systems and molecular mechanisms have been described and the overall conclusion is that retinoic acid is essential for life. This book series, with chapters authored by experts in every aspect of this complex field, unifies the knowledge base and mechanisms currently known in detailed, engaging, well-illustrated, focused chapters that synthesize information for each specific area. In view of the recent explosion in this field, it is timely to publish a contemporary, comprehensive, book series recapitulating the most exciting developments in the field and covering fundamental research in molecular mechanisms of vitamin A action, its role in physiology, development and continued well-being and the potential of vitamin A derivatives and synthetic mimetics to serve as therapeutic treatments for cancers and other debilitating human diseases. VOLUME I: Here, we present the first volume of a multi-volume series on Retinoic Acid Signaling that will cover all aspects of this broad and diverse field. One aim of Volume I is to present a compilation of topics related to the biochemistry of nuclear retinoic acid receptors, from their architecture when bound to DNA and associated with their coregulators to their ability to regulate target gene transcription. A second aim is to provide insight into recent advances that have been made in identifying novel targets and non-genomic effects of retinoic acid. Volume I is divided into ten chapters contributed by prominent experts in their respective fields. Each chapter starts with the history of the area of research. Then, the key findings that contributed to development of the field are described, followed by a detailed look at key findings and progress that are being made in current, ongoing research. Each chapter is concluded with a discussion of the relevance of the research and a perspective on missing pieces and lingering gaps that the author recommends will be important in defining future directions in vitamin A research.
  • Digital
    Mary Ann Asson-Batres, Cecile Rochette-Egly, editors.
    Springer2016
    Carotenoids and retinoids: nomenclature, chemistry, and analysis / Earl H. Harrison, Robert W. Curley Jr. -- Functions of intracellular retinoid binding-proteins / Joseph L. Napoli -- Vitamin A transport and cell signaling by the retinol-binding protein receptor stra6 / Noa Noy -- Vitamin A absorption, storage and mobilization / William S. Blaner, Yang Li, Pierre-Jacques Brun, Jason J. Yuen, Seung-Ah Lee [and others] -- Retinoic acid synthesis and degradation / Natalia Y. Kedishvili -- Cellular retinoic acid binding proteins: genomic and non-genomic functions and their regulation / Li-Na Wei -- Non-classical transcriptional activity of retinoic acid / Noa Noy -- Vitamin A as pkc co-factor and regulator of mitochondrial energetics / Ulrich Hammerling -- Vitamin A and vision / John C. Saari.
  • Digital
    Gottfried Schmalz, Dorthe Arenholt-Bindslev.
    Springer2009
  • Digital
    Greg T. Hermanson.
    ScienceDirect2013
    Bioconjugate Techniques, 3rd Edition, is the essential guide to the modification and cross linking of biomolecules for use in research, diagnostics, and therapeutics. It provides highly detailed information on the chemistry, reagent systems, and practical applications for creating labeled or conjugate molecules. It also describes dozens of reactions, with details on hundreds of commercially available reagents and the use of these reagents for modifying or crosslinking peptides and proteins, sugars and polysaccharides, nucleic acids and oligonucleotides, lipids, and synthetic polymers. *Offers a one-stop source for proven methods and protocols for synthesizing bioconjugates in the lab *Provides step-by-step presentation makes the book an ideal source for researchers who are less familiar with the synthesis of bioconjugates *Features full color illustrations *Includes a more extensive introduction into the vast field of bioconjugation and one of the most thorough overviews of immobilization chemistry ever presented.
  • Digital
    edited by Sonny S. Mark.
    Springer Protocols2011
    Site-specific labeling of proteins for single-molecule FRET measurements using genetically encoded ketone functionalities / Edward A. Lemke -- Enzymatically catalyzed conjugation of a biodegradable polymer to proteins and small molecules using microbial transglutaminase / Ahmed Besheer [and others] -- Synthesis of drug/dye-incorporated polymer-protein hybrids / Sukanta Dolai [and others] -- Dye/DNA conjugates as multiple labels for antibodies in sensitive fluorescence immunoassays / Qin Zhang, Shengchao Zhu, and Liang-Hong Guo -- Chemoselective modification of viral proteins bearing metabolically introduced "clickable" amino acids and sugars / Partha S. Banerjee and Isaac S. Carrico -- Preparation of peptide and other biomolecular conjugates through chemoselective ligations / Mathieu Galibert [and others] -- New fluorescent substrates of microbial transglutaminase and its application to peptide tag-directed covalent protein labeling / Noriho Kamiya and Hiroki Abe -- Covalent conjugation of poly(ethylene glycol) to proteins and peptides : strategies and methods / Anna Mero [and others] -- Extending the scope of site-specific cysteine bioconjugation by appending a prelabeled cysteine tag to proteins using protein trans-splicing / Tulika Dhar, Thomas Kurpiers, and Henning D. Mootz -- Polyethylenimine bioconjugates for imaging and DNA delivery in vivo / Andrea Masotti and Francesco Pampaloni -- Synthesis of a glycomimetic oligonucleotide conjugate by 1,3-dipolar cycloaddition / Gwladys Pourceau [and others] -- Site-specific DNA labeling by staudinger ligation / Samuel H. Weisbrod, Anna Baccaro, and Andreas Marx -- Improved cellular uptake of antisense peptide nucleic acids by conjugation to a cell-penetrating peptide and a lipid domain / Takehiko Shiraishi and Peter E. Nielsen -- Synthesis of oligonucleotide-peptide conjugates for biomedical and technological applications / Anna Avino [and others] -- Amphiphilic DNA block copolymers : nucleic acid-polymer hybrid materials for diagnostics and biomedicine / Jan Zimmermann [and others] -- Chemically selective liposome surface glyco-functionalization / Hailong Zhang, Yong Ma, and Xue-Long Sun -- Bioconjugation using mutant glycosyltransferases for the site-specific labeling of biomolecules with sugars carrying chemical handles / Boopathy Ramakrishnan [and others] -- Lipid-core-peptide system for self-adjuvanting synthetic vaccine delivery / Mariusz Skwarczynski and Istvan Toth -- Coupling carbohydrates to proteins for glycoconjugate vaccine development using a pentenoyl group as a convenient linker / Qianli Wang and Zhongwu Guo -- Conjugation of LPS-derived oligosaccharides to proteins using oxime chemistry / Joanna Kubler-Kielb -- Site-specific chemical modification of a glycoprotein fragment expressed in yeast / Junpeng Xiao and Thomas J. Tolbert -- On-resin convergent synthesis of a glycopeptide from HIV gp120 containing a high mannose type N-linked oligosaccharide / Rui Chen and Thomas J. Tolbert -- Design and synthesis of novel functional lipid-based bioconjugates for drug delivery and other applications / Rupa R. Sawant and Vladimir P. Torchilin -- Chemical functionalization and bioconjugation strategies for atomic force microscope cantilevers / Magnus Bergkvist and Nathaniel C. Cady -- Chemoselective protein and peptide immobilization on biosensor surfaces / Edith H.M. Lempens, Brett A. Helms, and Maarten Merkx -- Fabrication of dynamic self-assembled monolayers for cell migration and adhesion studies / Nathan P. Westcott and Muhammad N. Yousaf -- DNA detection using functionalized conducting polymers / Jadranka Travas-Sejdic [and others] -- Preparation and dynamic patterning of supported lipid membranes mimicking cell membranes / Stefan Kaufmann, Karthik Kumar, and Erik Reimhult -- Enzyme immobilization on reactive polymer films / Ana L. Cordeiro [and others] -- Characterization of protein-membrane binding interactions via a microplate assay employing whole Liposome Immobilization / Matthew D. Smith and Michael D. Best -- Bioconjugated phospholipid polymer biointerface with nanometer-scaled structure for highly sensitive immunoassays / Kazuki Nishizawa, Madoka Takai, and Kazuhiko Ishihara -- Purification, functionalization, and bioconjugation of carbon nanotubes / John H.T. Luong [and others] -- Functional integration of membrane proteins with nanotube and nanowire transistor devices / Aleksandr Noy [and others] -- Single-step conjugation of antibodies to quantum dots for labeling cell surface receptors in mammalian cells / Gopal Iyer, Jianmin Xu, and Shimon Weiss -- Practical strategy for constructing nanodrugs using carbon nanotubes as carriers / Wei Wu and Xiqun Jiang -- Design and synthesis of biofunctionalized metallic/magnetic nanomaterials / Eun-Kyung Lim [and others].
  • Digital/Print
    Stefanos Zenios, Josh Makower, Paul Yock.
    Digital : ProQuest Safari2010
    Print2010
    Stage 1. Needs finding -- 1.1. Strategic focus -- 1.2. Observation and problem identification -- 1.3. Need statement development -- Stage 2. Needs screening -- 2.1. Disease state fundamentals -- 2.2. Treatment options -- 2.3. Stakeholder analysis -- 2.4. Market analysis -- 2.5. Needs filtering -- Stage 3. Concept generation -- 3.1. Ideation and brainstorming -- 3.2. Concept screening -- Stage 4. Concept selection -- 4.1. Intellectual property basics -- 4.2. Regulatory basics -- 4.3. Reimbursement basics -- 4.4. Business models -- 4.5. Prototyping -- 4.6. Final concept selection -- Stage 5. Development strategy and planning -- 5.1. Intellectual property strategy -- 5.2. Research and development strategy -- 5.3. Clinical strategy -- 5.4. Regulatory strategy -- 5.5. Quality and process management -- 5.6. Reimbursement strategy -- 5.7. Marketing and stakeholder strategy -- 5.8. Sales and distribution strategy -- 5.9. Competitive advantage and business strategy -- Stage 6. Integration -- 6.1. Operating plan and financial model -- 6.2. Business plan development -- 6.3. Funding sources -- 6.4. Licensing and alternate pathways.
  • Print
    editors, Paul G. Yock, Stefanos Zenios, Joshua Makower, Todd J. Brinton, Uday N. Kumar, F.T. Jay Watkins ; principal writer, Lyn Denend ; specialy editor, Thomas M. Krummel ; web editor, Christina Kurihara.
    Status: Not Checked OutLane Catalog Record
    "This step-by-step guide to medical technology innovation, now in full color, has been rewritten to reflect recent trends of industry globalization and value-conscious healthcare. Written by a team of medical, engineering, and business experts, the authors provide a comprehensive resource that leads students, researchers, and entrepreneurs through a proven process for the identification, invention, and implementation of new solutions. Case studies on innovative products from around the world, successes and failures, practical advice, and end-of-chapter 'Getting Started' sections encourage readers to learn from real projects and apply important lessons to their own work. A wealth of additional material supports the book, including a collection of nearly 100 videos created for the second edition, active links to external websites, supplementary appendices, and timely updates on the companion website at ebiodesign.org. Readers can access this material quickly, easily, and at the most relevant point in the text from within the ebook"--Provided by publisher.
  • Digital
    David G. Nicholls, Stuart J. Ferguson.
    ScienceDirect2013
    Extensively revised, the fourth edition of this highly successful book takes into account the many newly determined protein structures that provide molecular insight into chemiosmotic energy transduction, as well as reviewing the explosive advances in 'mitochondrial physiology'-the role of the mitochondria in the life and death of the cell. Covering mitochondria, bacteria and chloroplasts, the fourth edition of Bioenergetics provides a clear and comprehensive account of the chemiosmotic theory and its many applications. The figures have been carefully designed to be memorable and to convey the key functional and mechanistic information. Written for students and researchers alike, Bioenergetics is the most well-known, current and respected text on chemiosmotic theory and membrane bioenergetics available. Chapters are now divided between three interlocking sections: basic principles, structures and mechanisms, and mitochondrial physiology. Covers new advances in the structure and mechanism of key bioenergetic proteins, including complex I of the respiratory chain and transport proteins.Details cellular bioenergetics, mitochondrial cell biology and signal transduction, and the roles of mitochondria in physiology, disease and aging.Offers readers clear, visual representation of structural concepts through full colour figures throughout the book.
  • Digital/Print
    Penefsky, Harvey S.; Schäfer, Günter.
    Digital : Springer2008
    Print2008
    Diversity of the heme-copper superfamily in Archaea: insights from genomics and structural modeling / James Hemp, Robert B. Gennis -- Structure of Photosystems I and II / Petra Fromme, Ingo Grotjohann -- Microbial rhodopsins: scaffolds for ion pumps, channels, and sensors / Johann P. Klare, Igor Chizhov, Martin Engelhard -- Life close to the thermodynamic limit: how methanogenic Archaea conserve energy / Uwe Deppenmeier, Volker Müller -- ATP synthesis by decarboxylation phosphorylation / Peter Dimroth, Christoph von Ballmoos -- The three families of respiratory NADH dehydrogenases / Stefan Kerscher ... [et al.] -- Hydrogenases and H+-reduction in primary energy conservation / Paulette M. Vignais -- A structural perspective on mechanism and function of the cytochrome bc1 complex / Carola Hunte ... [et al.] -- Regulatory mechanisms of proton-translocating FoF1-ATP synthase / Boris A Feniouk, Masasuke Yoshida.
  • Digital
    edited by Suresh C. Sikka, Wayne J.G. Hellstrom.
    ScienceDirect2017
    Bioenvironmental Issues Affecting Men's Reproductive and Sexual Health is structured into two parts related to men's reproductive and sexual health with eight sections designed to enable a logical flow of such knowledge. The book is focused on the biology of key organs involved in male reproduction and the environmental influences affecting their functions with particular emphasis on clinical aspects. Individual chapters within the book range from basic to translational aspects, but all hold clinical relevance. This is an essential reference for those working and learning in the field of human reproduction, reproductive toxicology and environmental influences on reproductive and sexual health.
  • Print
    F. M. Kamm.
    Rescuing Ivan Ilych -- Conceptual issues related to ending life -- Problems with "assisted suicide -- Four-step arguments for physician-assisted suicide and euthanasia -- Some arguments by Velleman concerning suicide and assisted suicide -- Brody on active and passive euthanasia -- A note on dementia and advance directives -- Brain death and spontaneous breathing -- Using human embryos for biomedical research -- Ethical issues in using and not using human embryonic stem cells -- Ronald Dworkin's views on abortion -- Creation and abortion short -- McMahan on the ethics of killing at the margins of life -- Some conceptual and ethical issues in Munchausen Syndrome by Proxy -- Genes, justice, and obligations to future people -- Moral status, personal Identity, and substitutability -- What is and is not wrong with enhancement? -- Health and equity -- Health and equality of opportunity -- Is it morally permissible to discontinue nontutile use of a scarce resource? -- Aggregation, allocating scarce resources, and discrimination against the disabled -- Rationing and the disabled -- Learning from bioethics -- The philosopher as insider and outsider -- Theory and analogy in law and philosophy -- Types of relations between theory and practice -- Understanding, justifying, and finding oneself.
  • Print
    by Barry R. Furrow, Professor of Law and Director, Health Law Program, Drexel University; Thomas L. Greaney, Chester A. Myers Professor of Law and Co-Director, Center for Health Law Studies, Saint Louis University; Sandra H. Johnson, Professor Emerita of Law and Health Care Ethics, Center for Health Law Studies, Saint Louis University School of Law; Timothy Stolzfus Jost, Robert L. Willett Family Professor of Law, Washington and Lee University; Robert L. Schwartz, Senor Visiting Professor, University of California Hastings College of the Law, Weihofen Professor of Law Emeritus, University of New Mexico.
    An introduction to the study of ethics and ethical theories -- Reproduction and birth -- Legal issues in human genetics -- Organ transplantation and the determination of death -- Life and death decisions -- Medically assisted dying -- -- Regulation of research involving human subjects -- Population health and public health.
  • Digital
    Insoo Hyun, Case Western Reserve University.
    Cambridge2013
    "This book provides a sophisticated yet accessible account of emerging trends in stem cell research and their accompanying ethical issues"-- Provided by publisher.
  • Print
    by Sarah Ferber.
    Introduction -- Bioethics as scholarship -- Language, narrative and rhetoric in bioethics -- Euthanasia, the Nazi analogy and the slippery slope -- Heredity, genes and reproductive politics -- Human experimentation -- Thalidomide.
  • Print
    series editors, James F. Childress ... [et al.].
    Status: Not Checked OutLane Catalog Record
  • Digital/Print
    Gianfranco Donelli, editor.
    Digital : Springer2015
    Print2015
    The aim of this book is to provide readers with a wide overview of the main healthcare-associated infections caused by bacteria and fungi able to grow as biofilm. The recently acquired knowledge on the pivotal role played by biofilm-growing microorganisms in healthcare-related infections has given a new dynamic to detection, prevention and treatment of these infections in patients admitted to both acute care hospitals and long-term care facilities. Clinicians, hygienists and microbiologists will be updated by leading scientists on the state-of-art of biofilm-based infections and on the most innovative strategies for prevention and treatment of these infections, often caused by emerging multidrug-resistant biofilm-growing microorganisms.
  • Digital/Print
    Gianfranco Donelli, editor.
    Digital : Springer2015
    Print2015
    The aim of this book is to provide readers with a wide overview of the main healthcare-associated infections caused by bacteria and fungi able to grow as biofilm. The recently acquired knowledge on the pivotal role played by biofilm-growing microorganisms in healthcare-related infections has given a new dynamic to detection, prevention and treatment of these infections in patients admitted to both acute care hospitals and long-term care facilities. Clinicians, hygienists and microbiologists will be updated by leading scientists on the state-of-art of biofilm-based infections and on the most innovative strategies for prevention and treatment of these infections, often caused by emerging multidrug-resistant biofilm-growing microorganisms.
  • Digital
    Thomas Bjarnsholt, Peter Østrup Jensen, Claus Moser, Niels Høiby, editors.
    Springer2011
    There has been an increasing interest and emphasis on the sessile bacterial lifestyle biofilms since it was discovered that the vast majority of the total microbial biomass exists as biofilms. Leeuwenhoek first described the aggregation of bacteria in 1677, but it was only recently recognized as being important in chronic infection. In 1993, the American Society for Microbiology (ASM) recognized that the biofilm mode of growth was relevant to microbiology. This book covers both the evidence for biofilms in many chronic bacterial infections as well as the problems facing these infections such as diagnostics, pathogenesis, treatment regimes, and in vitro and in vivo models for studying biofilms. This is the first scientific book on biofilm infections, with chapters written by world- renowned scientists and clinicians. The intended audience of this book includes scientists, teachers at the university level, as well as clinicians.
  • Digital
    edited by Iqbal Ahmad, Fohad Mabood Husain.
    Wiley2017
    Biofilms : an introduction and significance in plant and soil health -- Role of PGPR in biofilm formations and its importance in plant health -- Concept of mono and mixed biofilms and their role in soil and in plant association -- Bacillus biofilms and their role in plant health -- Biofilm formation by Psedumonas spp. and their significance in biocontrol -- Quorum sensing mechanisms in rhizosphere biofilms -- Biofilm formation and quorum sensing in the rhizosphere -- The significance of fungal biofilms in association with plants and soils -- Chemical nature of biofilm matrix and its significance -- Root exudates : composition and impact on plant-microbe interaction -- Biochemical and molecular mechanism in biofilm studies in plant associated bacteria -- Techniques in studying biofilms and their characterization : microscopy to advanced imaging systems in vitro and in situ -- Gene expression and enhanced antimicrobial resistance in biofilms -- In vitro assessment of biofilm formation by soil and plant associated microorganisms -- Biotic and abiotic factors affecting biofilm in vitro and in the rhizosphere -- The ecological significance of soil associated biofilms and stress management -- Developed biofilm-based microbial ameliorators for bioremediating degraded ecosystems and the environment -- Bioremediation and biofilm in soil and plant root association -- Biofilms for remediation of heavy metals and xenobiotic compounds : a technical review -- Plant pathogenic bacteria : role of quorum sensing and biofilm in disease development -- Plant pathogenic bacteria biofilm instigation and its control measures -- Application of biofilm and quorum sensing inhibitors in food protection and safety -- Biofilm inhibition by natural products of marine origin and their environmental application -- Biofilm formation by enteric pathogens on plants and its impact on human health -- Role of in silico studies in designing QS/antibiofilm agents for controlling biofouling and plant diseases.
  • Digital
    Diana Marie Proctor.
    This thesis is concerned with understanding the biogeography of the human oral microbiota, defining the types and extent of spatial patterns observed in the communities of the oral cavity, as well as the underlying causal mechanisms governing those patterns. First, I provide an overview of spatial ecology and, in a review, discuss how applying the context, principles and methods of spatial ecology to the study of the human microbiota will enable us as a field to move beyond the descriptive statistics that have dominated our biogeographic surveys since the time of Leeuwenhoek (Chapter 1). Second, I review extant literature surveying the biogeography of the human microbiome, of all major body site habitats, providing a critical review that yields insight into the limitations of existing biogeographic surveys (Chapter 2). Third, I identify an ecological gradient that structures the microbial communities that inhabit the exposed surfaces of teeth and which runs between the front of the mouth and its back (Chapter 3). This is the first demonstration of an ecological gradient, that is not a successional gradient, in the human oral cavity, a departure from previous reports that communities are categorically distinct from one another, varying simply by tooth number or tooth class. Fourth, I demonstrate that the anterior to posterior ecological gradient observed for supragingival communities is shared by communities inhabiting multiple tissues, including the alveolar mucosa, keratinized gingiva, and buccal mucosa, highlighting the importance of examining multiple spatial scales in studies of the human microbiota (Chapter 4). Fifth, I tested the hypothesis that reduced salivary flow homogenizes the observed spatial structure of microbial communities (Chapter 5). This is the first demonstration that, in healthy humans, salivary flow mechanistically drives the segregation of human oral microbial communities, maintaining the spatial architecture of bacterial communities across teeth in healthy humans. Taken together, these studies provide novel insight into the biogeography of the human oral microbiota, and how it pertains to human health and disease.
  • Print
    compiled by Geraldine Rhoades Beckford.
    Status: Not Checked OutLane Catalog Record
    "Presents biographical information on physicians of African ancestry who practiced in the United States or taught those who practiced in the U.S. between 1800 and 1920. Features more than 3,000 entries that provide the physician's birth and death dates, place of practice, medical school and year of graduation, birthplace, parents, spouse, and children. Includes a geographical index"--Provided by publisher.
  • Digital
    D. Lynn Loriaux, MD, PhD.
    Wiley2016
  • Digital/Print
    Errol C Friedberg, University of Texas Southwestern Medical Center at Dallas, USA ; foreword by Sydney Brenner.
    Digital : World Scientific2014
    Print2014
    Growing up in Brooklyn -- The essential Paul Berg -- College and World War II -- Western Reserve University -- Copenhagen -- Washington University, St. Louis -- Discovering transfer RNA -- Stanford University and its refurbished Department of Biochemistry -- Transcription and translation : new directions -- Making recombinant DNA : the first faltering steps -- Making recombinant DNA : a major breakthrough -- EcoRI restriction endonuclease : a major breakthrough -- "Coincidence is the word we use when we can't see the levers and pulleys" -- Yet another Stanford contribution -- An historic meeting in Hawaii -- The recombinant DNA controversy -- A momentous Gordon Research Conference -- Making recombinant molecules with frog DNA -- The controversy heats up -- Asilomar II -- The dissenters : a different point of view -- The aftermath -- Legislative and revisionist challenges to recombinant DNA -- Asilomar II : lessons learned -- The Nobel Prize in chemistry -- Commercializing the technology -- Life goes on -- The "retirement" years -- Public policy issues : and other interests -- Personal challenges.
  • Digital
    edited by Jonathan M. Keith.
    Springer Protocolsv. 1, 2008
    Springer Protocolsv. 2, 2008
    v. 1. Data, sequence analysis, and evolution -- v. 2. Structure, function, and applications.
  • Digital
    Venkatarajan Subramanian Mathura and Pandjassarame Kangueane, [editors].
    Springer2009
  • Digital
    edited by M.H. Fulekar.
    Springer2009
  • Digital
    David Edwards, Jason E. Stajich, David Hansen, editors.
    Springer2009
    DNA Sequence Databases / David Edwards, David Hansen and Jason E. Stajich -- Sequence Comparison Tools / Michael Imelfort -- Genome Browsers / Sheldon McKay and Scott Cain -- Predicting Non-coding RNA Transcripts / Laura A. Kavanaugh and Uwe Ohler -- Gene Prediction Methods / William H. Majoros, Ian Korf and Uwe Ohler -- Gene Annotation Methods / Laurens Wilming and Jennifer Harrow -- Regulatory Motif Analysis / Alan Moses and Saurabh Sinha -- Molecular Marker Discovery and Genetic Map Visualisation / Chris Duran, David Edwards and Jacqueline Batley -- Sequence Based Gene Expression Analysis / Lakshmi K. Matukumalli and Steven G. Schroeder -- Protein Sequence Databases / Terry Clark -- Protein Structure Prediction / Sitao Wu and Yang Zhang -- Classification of Information About Proteins / Amandeep S. Sidhu, Matthew I. Bellgard and Tharam S. Dillon -- High-Throughput Plant Phenotyping - Data Acquisition, Transformation, and Analysis / Matthias Eberius and José Lima-Guerra -- Phenome Analysis of Microorganisms / Christopher M. Gowen and Stephen S. Fong -- Standards for Functional Genomics / Stephen A. Chervitz, Helen Parkinson, Jennifer M. Fostel, Helen C. Causton and Susanna-Assunta Sanson, et al. -- Literature Databases / J. Lynn Fink -- Advanced Literature-Mining Tools / Pierre Zweigenbaum and Dina Demner-Fushman -- Data and Databases / Daniel Damian -- Programming Languages / John Boyle.
  • Digital
    edited by William T. Loging.
    Cambridge2016
    "Computational biology drives discovery through its use of high-throughput informatics approaches. This book provides a road map of the current drug development process and how computational biology approaches play a critical role across the entire drug discovery pipeline. Through the use of previously unpublished, real-life case studies the impact of a range of computational approaches are discussed at various phases of the pipeline. Additionally, a focus section provides innovative visualisation approaches, from both the drug discovery process as well as from other fields that utilise large datasets, recognising the increasing use of such technology. Serving the needs of early career and more experienced scientists, this up-to-date reference provides an essential introduction to the process and background of drug discovery, highlighting how computational researchers can contribute to that pipeline"--Provided by publisher.
  • Digital
    edited by Richard S. Larson, the University of New Mexio, Albuqerque, NM, USA.
    Springer Protocols2012
    Cell perturbation screens for target identification by RNAi / Kubilay Demir and Michael Boutros -- Using functional genomics to identify drug targets : a Dupuytren's disease example / Mirela Sedic, Sandra Kraljevic Pavelic, and Karlo Hock -- Functional characterization of human genes from exon expression and RNA interference results / Dorothea Emig [and others] -- Barcode sequencing for understanding drug-gene interactions / Andrew M. Smith [and others] -- High-throughput sequencing of the methylome using two-base encoding / Christina A. Bormann Chung -- Applications and limitations of in silico models in drug discovery / Ahmet Sacan, Sean Ekins, and Sandhya Kortagere -- Compound Collection Preparation for Virtual screening / Cristian G. Bologa and Tudor I. Oprea -- Mapping between databases of compounds and protein targets / Sorel Muresan, Markus Sitzmann, and Christopher Southan -- Predictive cheminformatics in drug discovery : statistical modeling for analysis of micro-array and gene expression data / N. Sukumar, Michael P. Krein, and Mark J. Embrechts -- Advances in nuclear magnetic resonance for drug discovery / Laurel O. Sillerud and Richard S. Larson -- Human ABC transporter ABCG2 in cancer chemotherapy : drug molecular design to circumvent multidrug resistance / Toshihisa Ishikawa [and others] -- Protein interactions : mapping interactome networks to support drug target discovery and selection / Javier De Las Rivas and Carlos Prieto -- Linking variants from genome-wide association analysis to function via transcriptional network analysis / Benjamin J. Keller, Sebastian Martini, and Viji Nair -- Models of excitation-contraction coupling in cardiac ventricular myocytes / M. Saleet Jafri -- Integration of multiple ubiquitin signals in proteasome regulation / Marta Isasa, Alice Zuin, and Bernat Crosas.
  • Print
    Jonathan Pevsner.
    Status: Not Checked OutLane Catalog Record
    Access to sequence data and literature information -- Pairwise sequence alignment -- Basic local alignment search tool (BLAST) -- Advanced database searching -- Multiple sequence alignment -- Molecular phylogeny and evolution -- Bioinformatic approaches to ribonucleic acid (RNA) -- Gene expression : microarray data analysis -- Protein analysis and proteomics -- Protein structure -- Functional genomics -- Completed genomes -- Completed genomes : viruses -- Completed genomes : bacteria and archaea -- The eukaryotic chromosome -- Eukaryotic genomes : fungi -- Eukaryotic genomes : from parasites to primates -- Human genome -- Human disease.
  • Digital
    Frederick Marcus.
    Springer2008
  • Digital
    Kevin Byron, New Jersey Institute of Technology, Newark, USA, Katherine G. Herbert, Montclair State University, New Jersey, USA, Jason T.L. Wang, New Jersey Institute of Technolog, Newark, USA.
    TandFonline2017
    Chapter 1. Overview of bioinformatics databases -- Chapter 2. Biological data cleaning -- Chapter 3. Biological data integration -- Chapter 4. Biological data searching -- Chapter 5. Biological data mining -- Chapter 6. Biological network inference -- Chapter 7. Cloud-based biological data processing.
  • Digital
    edited by Cathy H. Wu, Chuming Chen.
    Springer Protocols2011
    Protein bioinformatics databases and resources -- A guide to UniProt for protein scientists -- Interpro protein classification -- Reactome knowledgebase of human biological pathways and processes -- eFIP: A tool for mining functional impact of phosphorylation from literature -- A tutorial on protein ontology resources for proteomic studies -- Structure-guided rule-based annotation of protein functional sites in UniProt knowledgebase -- Modeling mass spectrometry-based protein analysis -- Protein identification from tandem mass spectra by database searching -- LC-MS data analysis for differential protein expression detection -- Protein identification by spectral networks analysis -- Software pipeline and data analysis for ms/ms proteomics: The trans-proteomic pipeline -- Analysis of high-throughput ELISA microarray data -- Proteomics databases and repositories -- Preparing molecular interaction data for publication -- Submitting proteomics data to PRIDE using PRIDE converter -- Automated data integration and determination of posttranslational modifications with the protein inference engine -- An integrated top-down and bottom-up strategy for characterization of protein isoforms and modifications -- Phosphoproteome resource for systems biology research -- Protein-centric data integration for functional analysis of comparative proteomics data -- Integration of proteomic and metabolomic profiling as well as metabolic modeling for the functional analysis of metabolic networks -- Time series proteome profiling.
  • Digital
    editor: Bairong Shen.
    Springer2013
    The book introduces the bioinformatics tools, databases and strategies for the translational research, focuses on the biomarker discovery based on integrative data analysis and systems biological network reconstruction. With the coming of personal genomics era, the biomedical data will be accumulated fast and then it will become reality for the personalized and accurate diagnosis, prognosis and treatment of complex diseases. The book covers both state of the art of bioinformatics methodologies and the examples for the identification of simple or network biomarkers. In addition, bioinformatics software tools and scripts are provided to the practical application in the study of complex diseases. The present state, the future challenges and perspectives were discussed. The book is written for biologists, biomedical informatics scientists and clinicians, etc.
  • Digital
    edited by David Posada.
    Springer Protocols2009
    Similarity searching using BLAST / Kit J. Menlove, Mark Clement, and Keith A. Crandall -- Gene orthology assessment with OrthologID / Mary Egan ... [et al.] -- Multiple alignment of DNA sequences with MAFFT / Kazutaka Katoh, George Asimenos, and Hiroyuki Toh -- SeqVis : a tool for detecting compositional heterogeneity among aligned nucleotide sequences / Lars Sommer Jermiin ... [et al.] -- Selection of models of DNA evolution with jModelTest / David Posada -- Estimating maximum likelihood phylogenies with PhyML / Stéphane Guindon ... [et al.] -- Trees from trees : construction of phylogenetic supertrees using clann / Christopher J. Creevey and James O. McInerney -- Detecting signatures of selection from DNA sequences using datamonkey / Art F.Y. Poon, Simon D.W. Frost, and Sergei L. Kosakovsky Pond -- Recombination detection and analysis using RDP3 / Darren P. Martin -- CodonExplorer : an interactive online database for the analysis of codon usage and sequence composition / Jesse Zaneveld ... [et al.] -- Genetic code prediction for metazoan mitochondria with GenDecoder / Federico Abascal, Rafael Zardoya, and David Posada -- Computational gene annotation in new genome assemblies using GeneID / Enrique Blanco and Josep F. Abril -- Promoter analysis : gene regulatory motif identification with A-GLAM / Leonardo Mariño-Ramírez ... [et al.] -- Analysis of genomic DNA with the UCSC Genome Browser / Jonathan Pevsner -- Mining for SNPs and SSRs using SNPServer, dbSNP and SSR taxonomy tree / Jacqueline Batley and David Edwards -- Analysis of transposable element sequences using CENSOR and RepeatMasker / Ahsan Huda and I. King Jordan -- DNA sequence polymorphism analysis using DnaSP / Julio Rozas.
  • Digital
    Naiara Rodríguez-Ezpeleta, Michael Hackenberg, Ana M. Aransay, editors.
    Springer2012
    Overview of sequencing technology platforms / Samuel Myllykangas, Jason Buenrostro, and Hanlee P. Ji -- Applications of high-throughput sequencing / Rodrigo Goya, Irmtraud M. Meyer, and Marco A. Marra -- Computational infrastructure and basic data analysis for high-throughput sequencing / David Sexton -- Base-calling for bioinformaticians / Mona A. Sheikh and Yaniv Erlich -- De novo short-read assembly / Douglas W. Bryant Jr. and Todd C. Mockler -- Short-read mapping / Paolo Ribeca -- DNA-protein interaction analysis (ChIP-Seq) / Geetu Tuteja -- Generation and analysis of genome-wide DNA methylation maps / Martin Kerick, Axel Fischer, and Michal-Ruth Schweiger -- Differential expression for RNA sequencing (RNA-Seq) data : mapping, summarization, statistical analysis, and experimental design / Matthew D. Young ... [et al.] -- MicroRNA expression profiling and discovery / Michael Hackenberg -- Dissecting splicing regulatory network by integrative analysis of CLIP-Seq data / Michael Q. Zhang -- Analysis of metagenomics data / Elizabeth M. Glass and Folker Meyer -- High-throughput sequencing data analysis software : current state and future developments / Konrad Paszkiewicz and David J. Studholme.
  • Digital
    Darren R. Flower, Matthew N. Davies, Shoba Ranganathan, editors.
    Springer2010
  • Digital
    edited by Bernd Mayer.
    Springer Protocols2011
    [Publisher-supplied data] Presenting an area of research that intersects with and integrates diverse disciplines, including molecular biology, applied informatics, and statistics, among others, Bioinformatics for Omics Data: Methods and Protocols collects contributions from expert researchers in order to provide practical guidelines to this complex study. Divided into three convenient sections, this detailed volume covers central analysis strategies, standardization and data-management guidelines, and fundamental statistics for analyzing Omics profiles, followed by a section on bioinformatics approaches for specific Omics tracks, spanning genome, transcriptome, proteome, and metabolome levels, as well as an assortment of examples of integrated Omics bioinformatics applications, complemented by case studies on biomarker and target identification in the context of human disease. Written in the highly successful Methods in Molecular Biology series format, chapters contain introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and accessible, Bioinformatics for Omics Data: Methods and Protocols serves as an ideal guide to scientists of all backgrounds and aims to convey the appropriate sense of fascination associated with this research field.
  • Print
    Darren R. Flower.
    Status: Not Checked OutLane Catalog Record
    Vaccines : their place in history -- Vaccines : need and opportunity -- Vaccines : how they work -- Vaccines : data and databases -- Vaccines : data driven prediction of binders, epitopes, and immunogenicity -- Vaccines : structural approaches -- Vaccines : computational solutions.
  • Digital
    edited by Gavin J. Gordon.
    Springer2009
    The emergence of bioinformatics : historical perspective, quick overview and future trends / Christos A. Ouzounis -- The statistical design and interpretation of microarray experiments / Kevin K. Dobbin and Richard M. Simon -- Whole-genome analysis of cancer / Steven A. Enkemann ... [et al.] -- Bioinformatics approaches to the analysis of the transcriptome of animal models of cancer / Mark J. Hoenerhoff ... [et al.] -- Significance of aberrant expression of miRNAs in cancer cells / George A. Calin ... [et al.] -- Proteomic methods in cancer research / Scot Weinberger and Egisto Boschetti -- Comprehensive genomic profiling for biomarker discovery for cancer detection, diagnostics and prognostics / Xiaofeng Zhou ... [et al.] -- Gene expression profiling of the leukemias : oncogenesis, drug responsiveness, and prediction of clinical outcome / Lars Bullinger, Hartmut Dohner, and Jonathon R. Pollack -- Personalized medicine in the clinical management of colorectal cancer / Anthony El-Khoueiry and Heinz Josef Lenz -- PIK3CA gene alterations in human cancers / Sérgia Velho, Carla Oliveira, and Raquel Seruca.
  • Digital
    editors, Arthur Gruber, Alan M. Durham, Chuong Huynh, and Hernado A. del Portillo.
    NCBI Bookshelf2008
    "This book is intended to serve both as a textbook for short bioinformatics courses and as a base for a self-teaching endeavor. "--Introduction.
  • Print
    Jorge L. Contreras and A. James Cuticchia, editors.
    "The book begins with an overview of the evolving bioinformatics field then explores legal issues surrounding the software tools that enable large-scale computational biology, including procurement and licensing of commercial software systems, in-house and contracted software development and issues surrounding open source software. Legal issues associated with software tools for large-scale computational biology are examined, including procurement and licensing of commercial software systems, in-house and contracted software development, and open source software." -- [Publisher-supplied data]
  • Digital
    editor: Xiangdong Wang.
    Springer2013
    Clinical Bioinformatics in Human Proteomics Research / Duojiao Wu, Haihao Li -- Proteomics Defines Protein Interaction Network of Signaling Pathways / Shitao Li -- Protein Function Microarrays: Design, Use and Bioinformatic Analysis in Cancer Biomarker Discovery and Quantitation / Jessica Duarte, Jean-Michel Serufuri, Nicola Mulder -- Proteomics and Cancer Research / Elena Lopez Villar -- Toward Development of Novel Peptide-Based Cancer Therapeutics: Computational Design and Experimental Evaluation / Elena Pirogova, Taghrid Istivan -- Advances in Proteomic Methods / Xianyin Lai -- Clinical and Biomedical Mass Spectrometry: New Frontiers in Drug Developments and Diagnosis / Ákos Végvári, Melinda Rezeli -- Disease Biomarkers: Modelling MR Spectroscopy and Clinical Applications / Luis Martí-Bonmati -- Processing of Mass Spectrometry Data in Clinical Applications / Dario Di Silvestre, Pietro Brunetti, Pier Luigi Mauri -- Bioinformatics Approach for Finding Target Protein in Infectious Disease / Hemant Ritturaj Kushwaha, Indira Ghosh -- Identification of Network Biomarkers for Cancer Diagnosis / Jiajia Chen, Luonan Chen -- Software Development for Quantitative Proteomics Using Stable Isotope Labeling / Xin Huang, Shi-Jian Ding -- Clinical Translation of Protein Biomarkers Integrated with Bioinformatics / Xu Yang, Juanjuan Zhou, Chaoqin Du -- Proteomic Approaches for Urine Biomarker Discovery in Bladder Cancer / Ming-Hui Yang, Yu-Chang Tyan -- Antibody Microarrays and Multiplexing / Jerry Zhou, Larissa Belov, Nicola Armstrong -- Proteomics in Anaesthesia and Intensive Care Medicine / Ornella Piazza, Giuseppe De Benedictis.
  • Digital
    Ion Măndoiu, Raj Sunderraman, Alexander Zelikovsky (eds.).
    Springer2008
  • Digital
    Pandjassarame Kangueane.
    Springer2009
  • Digital
    Minoru Taya, Makoto Mizunami, Shûhei Nomura, Elizabeth Van Volkenburgh.
    Cambridge2016
    From experts in engineering and biology, this is the first book to integrate sensor and actuator technology with bioinspired design.
  • Digital
    edited by C.M. Pradier, Y.J. Chabal.
    ScienceDirect2011
    IR spectroscopy has become without any doubt a key technique to answer questions raised when studying the interaction of proteins or peptides with solid surfaces for a fundamental point of view as well as for technological applications. Principle, experimental set ups, parameters and interpretation rules of several advanced IR-based techniques; application to biointerface characterisation through the presentation of recent examples, will be given in this book. It will describe how to characterise amino acids, protein or bacterial strain interactions with metal and oxide surfaces, by using infrared spectroscopy, in vacuum, in the air or in an aqueous medium. Results will highlight the performances and perspectives of the technique. Description of the principles, expermental setups and parameter interpretation, and the theory for several advanced IR-based techniques for interface characterisation. Contains examples which demonstrate the capacity, potential and limits of the IR techniques. Helps finding the most adequate mode of analysis. Contains examples. Contains a glossary by techniques and by keywords.
  • Digital
    edited by Nathan Brown.
    Wiley2012
  • Digital
    edited by Stephan Sudowe, Angelika B. Reske-Kunz.
    Springer Protocols2012
    Comparison between Agrobacterium-mediated and direct gene transfer using the gene gun / Caixia Gao and Klaus K. Nielsen -- Transient gene expression in epidermal cells of plant leaves by biolistic DNA delivery / Shoko Ueki [and others] -- Transformation of nuclear DNA in meristematic and embryogenic tissues / Mulpuri Sujatha and K.B.R.S. Visarada -- Biolistic DNA delivery to leaf tissue of plants with the non-vacuum gene gun (handygun) / Anssi L. Vuorinen [and others] -- Handgun-mediated inoculation of plants with viral pathogens for mechanistic studies / Victor Gaba, Moshe Lapidot, and Amit Gal-On -- Biolistics-based gene silencing in plants using a modified particle inflow gun / Kevin M. Davies [and others] -- Biolistic transformation of Caenorhabditis elegans / Meltem Isik and Eugene Berezikov -- Improved vectors for selection of transgenic Caenorhabditis elegans / Annabel A. Ferguson [and others] -- Biolistic transformation of Brugia Malayi / Tarig B. Higazi and Thomas R. Unnasch -- Biolistic transfection of human embryonic kidney (HEK) 293 cells / Xiongwei Li [and others] -- Biolistic transfection of tumor tissue samples / Kandan Aravindaram, Shu-Yi Yin, and Ning-Sun Yang -- Biolistic transfection of freshly isolated adult ventricular myocytes / David F. Steele, Ying Dou, and David Fedida -- Biolistic transfection of neurons in organotypic brain slices / John A. O'Brien and Sarah C.R. Lummis -- Biolistic DNA delivery to mice with the low pressure gene gun / Meng-Chi Yen and Ming-Derg Lai -- Chemokine overexpression in the skin by biolistic DNA delivery / Ahmad Jalili -- Enhancement of gene gun-induced vaccine-specific cytotoxic T-cell response by administration of chemotherapeutic drugs / Steve Pascolo -- Dendritic cell-specific biolistic transfection using the Fascin gene promoter / Yvonne Hohn, Stephan Sudowe, and Angelika B. Reske-Kunz -- Particle-mediated administration of plasmid DNA on corneas of BALB/c mice / Dirk Bauer [and others] -- Optimizing particle-mediated epidermal delivery of an influenza DNA vaccine in ferrets / Eric J. Yager [and others] -- Methods for monitoring gene gun-induced HBV and HCV-specific immune responses in mouse models / Gustaf Ahlen, Matti Sallberg, and Lars Frelin -- Gene gun immunization to combat malaria / Elke S. Bergmann-Leitner and Wolfgang W. Leitner -- Identification of T cell epitopes of Mycobacterium tuberculosis with biolistic DNA vaccination / Toshi Nagata and Yukio Koide -- Biolistic DNA vaccination against trypanosoma infection / Marianne Bryan, Siobhan Guyach, and Karen A. Norris -- Biolistic DNA vaccination against melanoma / Julia Steitz and Thomas Tuting -- Biolistic DNA vaccination against cervical cancer / Michal Smahel -- Efficiency of biolistic DNA vaccination in experimental type I allergy / Verena Raker [and others] -- Safety assessment of biolistic DNA vaccination / Barbara Langer [and others] -- DiOlistics: delivery of fluorescent dyes into cells / Nyssa Sherazee and Veronica A. Alvarez -- Protein antigen delivery by gene gun-mediated epidermal antigen incorporation (EAI) / Sandra Scheiblhofer [and others].
  • Digital
    Livio Luzi ; in collaborazione con Roberto Codella ... [et al.].
    Springer2010
  • Digital
    Alan L. Melnick.
    Springer2008
    Emergency preparedness for the primary care physician -- Biological terrorism -- Chemical terrorism -- Radiological terrorism -- Mental health and terrorism -- The primary care physician's role in supporting the public health response to biological, chemical, and radiological terrorism.
  • Digital
    edited by Trygve O. Tollefsbol.
    Springer Protocols2013
    Cell Senescence Culturing Methods / Huaping Chen, Yuanyuan Li, and Trygve O. Tollefsbol -- Digital Image Analysis of Cells Stained with the Senescence-Associated b-Galactosidase Assay / Liran I. Shlush and Sara Selig -- Analysis of Biomarkers of Caloric Restriction in Aging Cells / Yuanyuan Li and Trygve O. Tollefsbol -- Cell Sorting of Young and Senescent Cells / Graeme Hewitt, Thomas von Zglinicki, and Joã̃o F. Passos -- Studying the Replicative Life Span of Yeast Cells / David A. Sinclair -- Methods for Creating Mutations in C. elegans That Extend Lifespan / Dayong Wang, Min Cao, Jessica Dinh, and Yuqing Dong -- Aging Studies in Drosophila Melanogaster / Yaning Sun, Jason Yolitz, Cecilia Wang, Edward Spangler, Ming Zhan, and Sige Zou -- The Use of Calorie Restriction Mimetics to Study Aging / Munehiro Kitada and Daisuke Koya -- Using Somatic-Cell Nuclear Transfer to Study Aging / Satoshi Kishigami, Ah Reum Lee, and Teruhiko Wakayama -- Induction of Cellular Senescence by Oncogenic RAS / Romi Gupta and Narendra Wajapeyee -- Methods of Cellular Senescence Induction Using Oxidative Stress / Zhe Wang, Dandan Wei, and Hengyi Xiao -- Methods of Testing Pharmacological Drugs Effects on Aging and Life Span in Mice / Vadimir N. Anisimov, Irina G. Popovich, and Mark A. Zabezhinski -- Mitochondria-Targeted Antiaging Gene Therapy with Adeno-associated Viral Vectors / Dejia Li and Dongsheng Duan -- Real-Time Bioluminescence Functional Imaging for Monitoring Tissue Formation and Regeneration / Nadav Bleich Kimelman, Ilan Kallai, Dmitriy Sheyn, Wafa Tawackoli, Zulma Gazit, Gadi Pelled, and Dan Gazit -- Exometabolomic Mapping of Caenorhabditis elegans: A Tool to Noninvasively Investigate Aging / Robert J. Mishur, Jeffrey A. Butler, and Shane L. Rea -- Detecting Polymorphisms in Human Longevity Studies: HLA Typing and SNP Genotyping by Amplicon Sequencing / Gilberto Vargas-Alarcón and Carmina Flores-Domı́nguez -- Gel Electrophoresis-Based Proteomics of Senescent Tissues / Steven Carberry and Kay Ohlendieck -- Single-Cell Semiconductor Sequencing / Andrea B. Kohn, Tatiana P. Moroz, Jeffrey P. Barnes, Mandy Netherton, and Leonid L. Moroz -- Application of DNA Microarray Technology to Gerontological Studies / Kiyoshi Masuda, Yuki Kuwano, Kensei Nishida, and Kazuhito Rokutan -- Epigenetic Biomarker to Determine Replicative Senescence of Cultured Cells / Carmen M. Koch and Wolfgang Wagner -- Single-Neuron Transcriptome and Methylome Sequencing for Epigenomic Analysis of Aging / Leonid L. Moroz and Andrea B. Kohn
  • Digital
    [edited by] Roger Härtl, Lawrence J. Bonassar.
    Thieme MedOne Neurosurgery2017
    Although there have been significant advancements in minimally invasive spinal surgery techniques in the last few decades, optimal outcomes for chronic low back pain remain elusive. A number of promising clinical trials have been conducted using tissue engineering and biological interventions for disc degeneration. Written by renowned innovators, this is the first book that covers implementation of these groundbreaking approaches for disc disease. The text begins with key fundamentals including anatomy and physiology, pathophysiology, imaging and biomechanics to delineate healthy versus diseas.
  • Digital
    volume editors, W.P. Kaschka, D. Rujescu.
    Karger2016
    Global suicide / Varnik, P.; Wasserman, D -- Suicidal ideation, suicide attempts and completed suicide in adolescents : neurobiological aspects / Sarchiapone, M.; D'Aulerio, M.; Iosue, M -- Serotonergic and noradrenergic neurotransmitter systems in suicide / Dwivedi, Y -- GABA, depression and suicide / Pabba, M.; Sibille, E -- Genetics of suicidal behavior / Giegling, I.; Rujescu, D -- Gene-environment interaction studies in suicidal behaviour / Mandelli, L.; Serretti, A -- Epigenetics of suicidal behaviour / Turecki, G -- Neurocognitive processes and decision making in suicidal behaviour / Richard-Devantoy, S.; Courtet, P -- Electroencephalographic risk markers of suicidal behaviour / Hodgkinson, S.; Steyer, J.; Kaschka, W.P.; Jandl, M -- Neuroimaging of suicidal behavior / Jollant, F -- Inflammation and suicidal behavior / Postolache, T.T.; Manalai, P.; Brenner, L.A.; Brundin, L -- The contributions of lithium and clozapine for the prophylaxis and treatment of suicidal behavior / Müller-Oerlinghausen, B.; Lewitzka, U -- Challenges for future research and closing remarks / Rujescu, D.; Kaschka, I.N.; Kaschka, W.P.
  • Digital/Print
    Vasilis Vasiliou, Samir Zakhari, Helmut K. Seitz, Jan B. Hoek, editors.
    Digital : Springer2015
    Print2015
    In recent years, a significant amount of research has emerged connecting the link between alcohol and cancer. The field has rapidly advanced, especially since the complex connection between alcohol and cancer has several unique sub areas that are being investigated and this volume gives a comprehensive overview of these advancements.
  • Digital
    Jo C. Neill, Jayashri Kulkarni, editors.
    Springer2011
  • Digital
    volume editors, T. Banaschewski, L.A. Rohde.
    Karger2008
    Attention-deficit/hyperactivity disorder / Coghill, D., Rohde, L.A., Banaschewski, T. -- Autism / Moura, P.J., Lombroso, P.J., Mercadante, M.T. -- Brain model for pediatric bipolar disorder / Pavuluri, M.N., Bogarapu, S.P. -- Neurobiology of depression in childhood and adolescence / Bark, C., Resch, F. -- The neurobiological basis of anxiety in children and adolescents / Grados, M.A. -- Obsessive-compulsive disorder in childhood / Rosário, M.C. ... [et al.] -- Neurobiological background of tic disorders / Roessner, V., Rothenberger, A. -- Schizophrenia in children and adolescents / Remschmidt, H. -- Eating disorders / Fleitlich-Bilyk, B., Lock, J. -- Conduct disorder / Popma, A., Vermeiren, R. -- Substance use disorders in adolescence / Szobot, C.M., Bukstein, O. -- Molecular genetics in child psychiatry / Stringaris, A.K., Asherson, P. -- Recent developments in neuropsychological models of childhood psychiatric disorders / Willcutt, E.G. ... [et al.] -- Electrophysiology in child psychiatric disorders / Banaschewski, T., Brandeis, D. -- Neuroimaging in child psychiatry / Durston, S.
  • Digital
    edited by Ken Ishii and Choon Kit Tang
    ScienceDirect2014
    Biological DNA Sensor defines the meaning of DNA sensing pathways and demonstrates the importance of the innate immune responses induced by double stranded DNA (dsDNA) through its influencing functions in disease pathology and immune activity of adjuvants for vaccines. Though discussed in specific subsections of existing books, dsDNA and its immunogenic properties has never received the complete treatment given in this book. Biological DNA Sensor approaches the impact of dsDNA's immunogenicity on disease and vaccinology holistically. It paints a complete and concise picture on the topic so you can understand this area of study and make more informed choices for your respective research needs. Chapters are authored by researchers who are renowned for their research focus, ensuring that this book provides the most complete views on the topics. Multi-authored by a distinguished panel of world-class expertsIdeal source of information for those wanting to learn about DNA sensingProvides in-depth explanations of DNA sensing pathways and the innate immune system, bridging the gap between them
  • Digital
    Takemi Otsuki, Yasuo Yoshioka, Andrij Holian, editors.
    Springer2016
    This volume examines our current understanding of the biological effects of fibrous and particulate substances, including discussions on nanoparticles. It offers comprehensive information on the latest insights into the immunological effects of various irritants on the human body. Readers will benefit from the contributing authors' diverse perspectives and extensive discussions of key issues, which include molecular alterations of the immune system and autoimmune diseases in connection with asbestos and silica, among others. The chapters also discuss recommendations, practical methods, and nanosafety science in situations involving exposure to nanotoxic substances. Edited in collaboration with the Japanese Society for Hygiene, this book provides up-to-date information on the immunological effects of nanotoxic substances to researchers interested in environmental and occupational health. Presenting a number of recent concepts and findings in the field, it enables readers to gain a comprehensive knowledge of health problems caused by environmental fibrous and particulate substances.
  • Print
    edited by Madeleine F. Barnothy.
    Status: Not Checked OutLane Catalog Record
  • Digital
    ANSI2009Click fulltext button, Click guest acess (upper right) and Search for standard number 10993-1
  • Digital
    ANSI2006Click fulltext button, Click guest acess (upper right) and Search for standard number 10993-2
  • Digital
    ANSI2003Click fulltext button, Click guest acess (upper right) and Search for standard number 10993-3
  • Digital
    ANSI2009Click fulltext button, Click guest acess (upper right) and Search for standard number 10993-5
  • Digital
    ANSI2010Click fulltext button, Click guest acess (upper right) and Search for standard number 10993-13
  • Digital
    Lana Lau.
    A majority of biological microscopy investigations involve the focusing of visible light with conventional lenses. Fluorescence microscopy is one of the most widely used tools in biology but its resolution has historically suffered from the diffraction limit to about 200 nm laterally and 800 nm axially. In the past decade, this resolution problem has been overcome by the rapidly emerging field of super-resolution microscopy. The first demonstrated super-resolution technique, STimulated Emission Depletion (STED) Microscopy, is the topic of this Dissertation. This Dissertation has two primary areas of focus: the design optimization of a STED microscope, covered in Chapters 2-4, and its application to super-resolution imaging in cells and tissues, covered in Chapters 4-6. Chapter 2 describes the STED apparatus and experimental methods used. This chapter covers the guiding principles behind the design of a STED microscope, which forms a basis for understanding the logic underlying the homebuilt STED microscope which was constructed for this research. This STED microscope has a typical resolution of approximately 60 nm (full-width-at-half-maximum) or 25 nm (sigma) and has the sensitivity to image single fluorophores. In Chapter 3, a framework for evaluating and optimizing STED performance in the presence of several key tradeoffs is presented. Chapter 4 describes both developments in STED Microscopy required to utilize far-red-emitting dyes and the challenges associated with performing super-resolution imaging in intact Drosophila tissue. In Chapter 5, the optimization of labeling density revealed the 9-fold symmetry of a centriole protein structure, an important organelle in cell development. In Chapter 6, Huntingtin protein aggregates are resolved beyond the diffraction limit in a cell model of the neurodegenerative Huntington's disease.
  • Digital/Print
    edited by A.L. Burlingame.
    Digital : ScienceDirect2005
    Print2005
  • Digital
    edited by Ali Khademhosseini, Kahp-Yang Suh, Mohammed Zourob.
    Springer Protocols2010
    RNA and DNA microarrays / S.C. Sealfon and T.T. Chu -- Aptamer arrays / E. Baldrich -- Oligonucleotide microarrays for identification of microbial pathogens and detection of their virulence-associated or drug-resistance determinants / D.V. Volokhov ... [et al.] -- Protein microarrays printed from DNA microarrays / O. Stoevesandt, M. He and M.J. Taussig -- Lithographically defined two- and three-dimensional tissue microarrays / E.W. Gomez and C.M. Nelson -- Ratiometric lectin microarray analysis of the mammalian cell surface glycome / K.L. Hsu ... [et al.] -- Cell microarrays based on hydrogel microstructures for the application to cell-based biosensor / W.G. Koh -- Fabrication of bacteria and virus microarrays based on polymeric capillary force lithography / P.J. Yoo -- 3D polymer scaffold arrays / C.G. Simon, Jr. ... [et al.] -- PDMS microfluidic capillary systems for patterning proteins on surfaces and performing miniaturized immunoassays / M. Pla-Roca and D. Juncker -- Merging photolithography and robotic protein printing to create cellular microarrays / J.Y. Lee and A. Revzin -- Generation of protein and cell microarrays on functionalized surfaces / Y.S. Choi and C.S. Lee -- Microprinting of liver micro-organ for drug metabolism study / R.C. Chang ... [et al.] -- Microcontact printing / Y. Xie and X. Jiang -- Micromolding for the fabrication of biological microarrays / A.L. Galloway ... [et al.] -- Progress report on microstructured surfaces based on chemical vapor deposition / Y. Elkasabi and J. Lahann -- Methods for forming human microvascular tubes in vitro and measuring their macromolecular permeability / G.M. Price and J. Tien -- Microarray bioinformatics / R.P. Loewe and P.J. Nelson
  • Digital
    edited by Edgar Wingender.
    ProQuest Ebook Central2011
    It was suggested some years ago that Petri nets might be well suited to modeling metabolic networks, overcoming some of the limitations encountered by the use of systems employing ODEs (ordinary differential equations). Much work has been done since then which confirms this and demonstrates the usefulness of this concept for systems biology. Petri net technology is not only intuitively understood by scientists trained in the life sciences, it also has a robust mathematical foundation and provides the required degree of flexibility. As a result it appears to be a very promising approach to mode.
  • Digital
    Andrew Hodgkiss.
    Oxford Medicine Online2016
    Biological Psychiatry of Cancer and Cancer Treatment provides the reader with expert guidance on how to prevent, detect and manage the 'organic' psychiatric disorders experienced by people with cancer.
  • Print
    Sarah Franklin.
    Status: Not Checked OutLane Catalog Record
    Sarah Franklin explores the history and future of in vitro fertilization (IVF) thirty-five years and five million babies after its initial success as a form of technologically-assisted human reproduction.
  • Digital
    Barnali Chaudhuri, Inés G. Muñoz, Shuo Qian, Volker S. Urban, editors.
    Springer2017
    Sample and Buffer preparation for SAXS -- Considerations for sample preparation using size-exclusion chromatography -- How to analyze and present SAS data for publication -- Designing and Performing Biological Solution Small-Angle Neutron Scattering Contrast Variation Experiments on Multi-component Assemblies -- SAS-based structural modeling and model validation -- Structural Characterization of Highly Flexible Proteins by Small-Angle Scattering -- What can we learn from wide-angle solution scattering? -- SAS-based studies of protein fibrillation -- High Resolution Distance Distributions Determined by X-ray and Neutron Scattering -- A successful combination: coupling SE-HPLC with SAXS -- Applications of SANS to study membrane protein systems -- Hybrid applications of solution scattering to aid structural biology -- A practical guide to iSPOT modeling: An integrative structural biology platform -- Small angle scattering for pharmaceutical applications: From drugs to drug delivery system.
  • Digital
    Ronald F. van Vollenhoven.
    Springer2016
    Disease overview -- General treatment aspects -- Overview of biologic therapies -- Cytokine inhibitors -- B-cell directed therapy -- T-cell directed therapy -- Novel biologics and small molecules with biologic-like effects -- Strategies for the optimal use of biologic agents in rheumatoid arthritis -- Considerations for special patient populations -- Conclusions and future outlook.
  • Digital
    [edited by] James P. Stannard, James L. Cook, Lisa A. Fortier.
    Thieme-Connect2015
    US definitions, current use, and FDA stance on use of platelet-rich plasma in sports medicine / Knut Beitzel, Donald Allen, John Apostolakos, Ryan P. Russell, Mary Beth McCarthy, Gregory J. Gallo, Mark P. Cote, and Augustus D. Mazzocca -- European definitions, current use, and EMA stance of platelet-rich plasma in sports medicine / Stefano Fiorentino, Alice Roffi, Giuseppe Filardo, Maurilio Marcacci, and Elizaveta Kon -- FDA regulation of adult stem cell therapies as used in sports medicine / Mary Ann Chirba, Berkley Sweetapple, Charles P. Hannon, and John A. Anderson -- Cellular chondroplasty : a new technology for joint regeneration / Mary Murphy and Frank Barry -- Autologous-conditioned serum : evidence for use in the knee / David D. Frisbie -- Role of platelet-rich plasma in articular cartilage injury and disease / Randy Mascarenhas, Bryan M. Saltzman, Lisa A. Fortier, and Brian J. Cole -- Use of platelet-rich plasma for patellar tendon and medial collateral ligament injuries : best current clinical practice / Isabel Andia and Nicola Maffulli -- Can platelet-rich plasma enhance anterior cruciate ligament and meniscal repair? / Ian D. Hutchinson, Scott A. Rodeo, Gabriel S. Perrone, Martha M. Murray -- How should we evaluate outcomes for use of biologics in the knee? / Christopher M. LaPrade, Evan W. James, Robert F. LaPrade, Lars Engebretsen -- Biologics used in bone healing / Brett D. Crist and Gregory J. Della Rocca -- Clinical decision making for use of biologics in orthopaedic practice / James L. Cook and James P. Stannard.
  • Digital
    Ivan D. Montoya, editor.
    Springer2016
    Introduction -- PART I: Vaccines: Introduction -- Nicotine -- Cocaine -- Heroin -- Metamphetamine -- PART II: Monoclonal antibodies: Introduction -- Cocaine -- Metamphetamine -- PCP -- PART III: Enzymes: Introduction -- Butyrylcholinesterase -- Cocaine Esterase -- PART IV: New strategies to optimize the development of biologics: Adenovirus based vaccines -- Nanotechnology based vaccines -- Protein Nanoparticles -- DNA Scaffolded Vaccines -- Single Hapten Conjugate Therapeutic Vaccine -- Vaccine Adjuvants -- Laser Adjuvant -- Peptide Conjugates & Cytokine Adjuvants -- T. brucei: A Platform for Immunization -- Vaccines for SUDs and HIV infection -- New Monoclonal Antibodies -- Protein Engineered for Controlled Duration of Action -- PART V: Ethical aspects of biologics to treat SUDs.
  • Print
    Ludwig von Bertalanffy.
    Status: Not Checked OutLane Catalog Record
  • Digital
    edited by Ajaykumar Vishwakarma, Jeffrey M. Karp.
    ScienceDirect2017
    I. Biology of stem cell niches and molecular mechanisms -- The need to study, mimic, and target stem cell niches -- Harnessing the biology of stem cells' niche -- Pluripotent stem cell microenvironment -- Regulation of hematopoietic stem cell dynamics by molecular niche signaling -- HSC niche: regulation of mobilization and homing -- Neuronal stem cells niches of the brain -- Cardiovascular stem cell niche -- Intestinal epithelial Lgr5+ stem cell niche and organoids -- The epithelial stem cell niche in skin -- The satellite cell niche in skeletal muscle -- The cancer stem cell niche -- Cellular senescence and stem cell niche -- Biochemical and physical cues in the stem cell niche directing cell fate -- Matrix chemistry controlling stem cell behavior -- Matrix growth factor and surface ligand presentation -- Effects of matrix mechanical forces and geometry on stem cell behavior -- Wettability effect on stem cell behavior -- Fluid flow control of stem cells with investigation of mechanotransduction pathways -- Hypoxia regulation of stem cell: mechanisms, biological properties, and applications -- III. Designing smart biomaterials to mimic and control stem cell niche -- Polymer design and development -- Design and development of ceramics and glasses -- Surface functionalization of biomaterials -- Biofunctional hydrogels for three-dimensional stem cell culture -- Technologies to engineer cell substrate mechanics in hydrogels -- Micro- and nanosurface patterning technologies -- Self-assembled nanostructures (SANs) -- Biometric nanofibers as artificial stem cell niche -- IV. Bioengineering strategies to model synthetic stem cell niches -- Employing microfluidic devices to induce concentration gradients -- Engineering niches for embryonic and induced pluripotent stem cells -- Engineering niches for cardiovascular tissue regeneration -- Engineering niches for blood vessel regeneration -- Engineering niches for bone tissue regeneration -- Engineering vascular niche for bone tissue regeneration -- Engineering niches for cartilage tissue regeneration -- Engineering niches for stem and progenitor cell differentiation into immune cells -- Engineering niches for skin and wound healing -- Designing stem cell niche for liver development and regeneration -- Engineering the niche for intestinal regeneration.
  • Digital
    edited by Alan Trounson, Californian Institute for Regenerative Medicine, San Francisco, CA, USA, Roger Gosden, Center for Reproductive Medicine and Infertility, Weill Medical College of Cornell University, New York, NY, USA, Ursula Eichenlaub-Ritter, Faculty of Biology, Institute of Gene Technology/Microbiology, University of Bielefeld, Bielefeld, Germany.
    Cambridge2013
    Insights into the amphibian egg to understand the mammalian oocyte / Kei Miyamoto and John B. Gurdon -- Ontogeny of the mammalian ovary / Anne Grete Byskov and Claus Yding Andersen -- Gene networks in oocyte meiosis / Swapna Mohan and Paula E. Cohen -- Follicle formation and oocyte death / Melissa E. Pepling -- The early stages of follicular growth / Alain Gougeon -- Follicle and oocyte developmental dynamics / Aaron J.W. Hsueh and Kazuhiro Kawamura -- Mouse models to identify genes throughout oogenesis / Jia Peng, Qinglei Li, and Martin M. Matzuk -- Structural basis for oocyte-granulosa cell interactions / Ursula Eichenlaub-Ritter and Carlos Plancha -- Differential gene expression mediated by oocyte-granulosa cell communication / Saiichi Furukawa and Koji Sugiura -- Hormones and growth factors in the regulation of oocyte maturation / Marco Conti -- Getting into and out of oocyte maturation / Hayden Homer -- Chromosome behavior and spindle formation in mammalian oocytes / Heide Schatten and Qing-Yuan Sun -- Transcription, accumulation, storage, recruitment, and degradation of maternal mRNA in mammalian oocytes / Santhi Potireddy, Dasari Amarnath, and Keith E. Latham -- Setting the stage for fertilization: transcriptome and maternal factors / Boram Kim and Scott A. Coonrod -- Egg activation: initiation and decoding of Ca² signaling / John Carroll and Karl Swann -- In vitro growth and differentiation of oocytes / Hang Yin and Roger Gosden -- Metabolism of the follicle and oocyte in vivo and in vitro / Helen M. Picton and Karen E. Hemmings -- Improving oocyte maturation in vitro / Jeremy G. Thompson and Robert B. Gilchrist -- Human genes modulating primordial germ cell and gamete formation / Valerie L. Baker, Ruth Lathi, and Renee A. Reijo Pera -- In vitro differentiation of germ cells from stem cells / Fumihiro Sugawa, Karin Hübner, and Hans R. Schöler -- Parthenogenesis and parthenogenetic stem cells / Tiziana A.L. Brevini and Fulvio Gandolfi -- Epigenetic consequences of somatic cell nuclear transfer and induced pluripotent stem cell reprogramming / Jose Cibelli, Victoria L. Mascetti, and Roger A. Pedersen -- Primate and human somatic cell nuclear transfer / Rita P. Cervera and Shoukhrat Mitalipov -- Gene expression in human oocytes / Gayle M. Jones and David S. Cram -- Omics as tools for oocyte selection / Marc-André Sirard and Isabelle Gilbert -- The legacy of mitochondrial DNA / Helen A.L. Tuppen, Mary Herbert, and Doug M. Turnbull -- Relative contribution of advanced age and reduced follicle pool size on reproductive success: the quantity-quality enigma / Frank Broekmans and Madeleine Dólleman -- Cellular origin of age-related aneuploidy in mammalian oocytes / Ursula Eichenlaub-Ritter and Roger Gosden -- Alterations in the gene expression of aneuploidy oocytes and associated cumulus cells / Dagan Wells -- Transgerational risks by exposure in utero / Miguel A. Velazquez and Tom P. Fleming -- Obesity and oocyte quality / Rebecca L. Robker and Robert J. Norman -- Safety of ovarian stimulation / Dominic Stoop, Ellen Anckaert, and Johan Smitz -- Oocyte epigenetics and the risks for imprinting disorders associated with assisted reproduction / Serge McGraw and Jacquetta M. Trasler -- Genetic basis for primary ovarian insufficiency / Luca Persani, Stephanie Sherman, and Lawrence Nelson -- Polar body screening for aneuploidy in human oocytes / Luca Gianaroli, M. Cristina Magli, and Anna P. Ferraretti -- Cryopreservation of oocytes / Alan Trounson and Laura Rienzi -- Transplantation of ovarian tissue or immature oocytes to preserve and restore fertility in humans / Sherman Silber, Natalie Barbey, and David Silber.
  • Digital/Print
    edited by C. Yan Cheng.
    Digital : Springer2013
    Print2013
    Regulation of permeability across the blood-brain barrier / Alexander S. Easton -- Drug transporters at brain barriers : expression and regulation by neurological disorders / Tamima Ashraf ... [et al.] -- The blood-retina barrier : tight junctions and barrier modulation / Matthew Campbell and Peter Humphries -- The inner blood-retinal barrier : molecular structure and transport biology / Ken-Ichi Hosoya and Masanori Tachikawa -- Endothelial and epithelial barriers in graft-versus-host disease / Sam C. Nalle and Jerrold R. Turner -- Structure and regulation of intestinal epithelial tight junctions : current concepts and unanswered questions / Andrei I. Ivanov -- Polarity protein complex scribble/Lgl/Dlg and epithelial cell barriers / Wen-Hui Su ... [et al.] -- The blood-biliary barrier, tight junctions, and human liver diseases / Nikki P. Lee -- The blood-follicle barrier (BFB) in disease and in ovarian function / Michelle K.Y. Siu and C. Yan Cheng -- Physiology and pathophysiology of the epithelial barrier of the female reproductive tract : role of ion channels / Hsiao Chang Chan ... [et al.] -- The blood-epididymis barrier and human male fertility / Øvemie Dubø and Daniel G. Cyr -- Blood-tissue barriers : morphofunctional and immunological aspects of the blood-testis and blood-epididymal barriers / Luiz R. França ... [et al.] -- Gap junctions and blood-tissue barriers / Michelle W.M. Li, Dolores D. Mruk, and C. Yan Cheng -- Transcriptional regulation of cell adhesion at the blood-testis barrier and spermatogenesis in the testis / Wing-Yee Lui and C. Yan Cheng -- C-Src and c-Yes are two unlikely partners of spermatogenesis and their roles in blood-testis barrier dynamics / Xiang Xiao ... [et al.] -- Role of P-glycoprotein at the blood-testis barrier on adjudin distribution in the testis : a revisit of recent data / Linlin Su ... [et al.] -- The apical ectoplasmic specialization-blood-testis barrier functional axis is a novel target for male contraception / Ka-Wai Mok ... [et al.].
  • Digital
    edited by Kerry Atkinson.
  • Print
    Weinberg, Robert A.
    Status: Not Checked OutLane Catalog Record
    Thoroughly updated and incorporating the most important advances in the fast-growing field of cancer biology, This book is a textbook for students studying the molecular and cellular bases of cancer at the undergraduate, graduate, and medical school levels. The principles of cancer biology are presented in an organized, cogent, and in-depth manner. The clarity of writing, supported by an extensive full-color art program and numerous pedagogical features, makes the book accessible and engaging. The information unfolds through the presentation of key experiments that give readers a sense of discovery and provide insights into the conceptual foundation underlying modern cancer biology. Besides its value as a textbook, this book is a useful reference for individuals working in biomedical laboratories and for clinical professionals. Every copy of the book comes with an updated DVD-ROM containing the book's art program, a selection of movies, audio file mini-lectures, Supplementary Sidebars, and a Media Guide.
  • Print
    edited by Victor Ginsburg and Phillips Robbins.
    Status: Not Checked OutLane Catalog Record
  • Digital
    Timothy Wang, James G. Fox, Andrew S. Giraud, editors.
    Springer2009
  • Print
    edited by Ann M. Budy.
    Status: Not Checked OutLane Catalog Record
  • Digital
    Ryozo Nagai, Scott L. Friedman, Masato Kasuga, editors.
    Springer2009
    I. Overview. -- Krüppel-like Factors: Ingenious Three Fingers Directing Biology and Pathobiology / Ryozo Nagai, Ichiro Manabe and Toru Suzuki -- II. Molecular Control of Krüppel-like Factor Function. -- Molecular Structures of Krüppel-like Factors / Toshio Nagashima, Fumiaki Hayashi, Takashi Umehara and Shigeyuki Yokoyama -- Krüppel-like Factor Proteins and Chromatin Dynamics / Navtej S. Buttar, Gwen A. Lomberk, Gaurang S. Daftary and Raul A. Urrutia -- Co-regulator Interactions in Krüppel-like Factor Transcriptional Programs / Richard C. M. Pearson, Briony H. A. Jack, Stella H. Y. Lee, Alister P. W. Funnell and Merlin Crossley -- III. Krüppel-like Factors in Development and Differentiation. -- Developmental Expression of Krüppel-like Factors / Yizeng Yang and Jonathan P. Katz -- Expanded Role for EKLF/KLF1 Within the Hematopoietic Lineage / James J. Bieker -- Roles of Krüppel-like Factors in Lymphocytes / Kensuke Takada, Kristin A. Hogquist and Stephen C. Jameson -- Krüppel-like Factors in Gastrointestinal Tract Development and Differentiation / Marie-Pier Tétreault and Jonathan P. Katz -- Gene Interactions Between Krüppel-like Factors in Development / Joyce A. Lloyd -- Krüppel-like Factors in Stem Cell Biology / Masatsugu Ema, Satoru Takahashi and Yoshiaki Fujii-Kuriyama -- IV. Krüppel-like Factors in Organ Function and Disease. -- Krüppel-like Factors and the Liver / Goutham Narla and Scott L. Friedman -- Role of Krüppel-like Factor 15 in Adipocytes / Wataru Ogawa, Hiroshi Sakaue and Masato Kasuga -- Krüppel-like Factors in the Heart / Daiji Kawanami, Saptarsi M. Haldar and Mukesh K. Jain -- Krüppel-like Factors in the Vascular Endothelium / Guillermo García-Cardeña and Guadalupe Villarreal -- Krüppel-like Factors KLF2, KLF4, and KLF5: Central Regulators of Smooth Muscle Function / Christopher W. Moehle and Gary K. Owens -- Krüppel-like Factors in Cancers / Vincent W. Yang -- V. Diagnostic and Therapeutic Applications of Krüppel-like Factors. -- Krüppel-like Factors KLF6 and KLF6-SV1 in the Diagnosis and Treatment of Cancer / Analisa DiFeo, Goutham Narla and John A. Martignetti -- Drug Development and Krüppel-like Factors / Ichiro Manabe and Ryozo Nagai.
  • Digital
    Gregory J. Atkins, Sandra Amor, Jean M. Fletcher, Kingston H.G. Mills.
    Cambridge2012
    "Multiple sclerosis is the most common debilitating neurological disease in people under the age of forty in the developed world. Many publications cover medical and clinical approaches to the disease; however, The Biology of Multiple Sclerosis provides a clear and concise up-to-date overview of the scientific literature on the various theories of MS pathogenesis. Covering the main elements of scientific research into multiple sclerosis, the book contains chapters on the neuropathology of the disease as well as an account of the most extensively used animal model experimental autoimmune encephalomyelitis. The book contains chapters regarding the role of viruses in the development of multiple sclerosis. Viruses have long been implicated and chapters on animal models based on virus infection, as well as their possible role in the etiology of MS, are included. Of interest to MS researchers, the book is written to also be of value to postgraduate and medical students"-- Provided by publisher.
  • Digital
    meeting organized by Terri Grodzicker, Robert Martenssen, David Stewart, and Bruce Stillmann.
    Cold Spring Harb Lab Press2012
    "Plants are integral to human well being, and many species have been domesticated for more than 10,000 years. Evidence of plant scientific investigation and classification can be found in ancient texts from cultures around the world (Chinese, Indian, Greco-Roman, Muslim, etc.), whereas early modern botany can be traced to the late 15th and early 16th centuries in Europe. During the past several decades, plant biology has been revolutionized first by molecular biology and then by the genomic era. The model organism Arabidopsis thaliana has proved to be an invaluable tool for investigation into fundamental processes in plant biology, many of which share commonalities with animal biology. Plant-specific processes from reproduction to immunity and second messengers have also yielded to extensive investigation. With the genomes of more than 30 plant species now available and many more planned in the near future, the impact on our understanding of plant evolution and biology continues to grow. Our increased ability to engineer plant species to a variety of ends may provide novel solutions to ensure adequate and reliable food production and renewable energy even as climate change impacts our environment. The decision to focus the 2012 Symposium on plant science reflected the enormous research progress achieved in recent years and was intended to provide a broad synthesis of the current state of the field, setting the stage for future discoveries and application. This is the first Symposium in this historic series that focused exclusively on the botanical sciences. The Symposium spanned a broad range of areas of investigation including genetics, biochemistry, molecular and cell biology, developmental biology, physiology, and population/evolution studies at levels ranging from the single cell to the entire organism and from single genes to genomes; plant-specific processes and pathways featured broadly throughout the meeting. Effort was made to balance fundamental biological discoveries with applications relevant to societal well being including improved crops, fuel, and habitat"--Page xv.
  • Digital
    Héctor M. Alvarez, editor.
    Springer2010
    Systematics of Members of the Genus Rhodococcus (Zopf 1891) Emend Goodfellow et al. 1998: The Past, Present and Future / Volker Gűrtler and Robert J. Seviour -- The Rhodococcal Cell Envelope: Composition, Organisation and Biosynthesis / Iain C. Sutcliffe, Alistair K. Brown and Lynn G. Dover -- Genomes and Plasmids in Rhodococcus / Michael J. Larkin, Leonid A. Kulakov and Christopher C. R. Allen -- Central Metabolism of Species of the Genus Rhodococcus / Héctor M. Alvarez -- Adaptation of Rhodococcus to Organic Solvents / Carla C. C. R. de Carvalho -- Catabolism of Aromatic Compounds and Steroids by Rhodococcus / Katherine C. Yam, Robert van der Geize and Lindsay D. Eltis -- Catabolism of Nitriles in Rhodococcus / Ludmila Martínková, Miroslav Pátek, Alicja Barbara Veselá, Ondřej Kaplan and Bronislava Uhnáková, et al. -- The Desulfurization Pathway in Rhodococcus / Ting Ma -- Application of Rhodococcus in Bioremediation of Contaminated Environments / Maria S. Kuyukina and Irena B. Ivshina -- Physiology, Biochemistry, and Molecular Biology of Triacylglycerol Accumulation by Rhodococcus / Héctor M. Alvarez and Alexander Steinbüchel -- Rhodococcus Biosurfactants: Biosynthesis, Properties, and Potential Applications / Maria S. Kuyukina and Irena B. Ivshina -- Phytopathogenic Strategies of Rhodococcus fascians / Elisabeth Stes, Marcelle Holsters and Danny Vereecke -- Rhodococcus equi and Its Pathogenic Mechanisms / José A. Vázquez-Boland, Michal Letek, Ana Valero-Rello, Patricia González and Mariela Scortti, et al.
  • Digital/Print
    edited by James C. Whisstock and Phillip I. Bird.
    Digital : ScienceDirect2011
    Print2011
  • Digital
    Dov Zipori.
    Springer2009
  • Digital
    Tamás Rőszer.
    Springer2012
    This book fills in a gap in the NO literature. Recent progress in the field of NO-biology shows that NO is generated within distinct cell compartments, including specific plasma membrane regions, mitochondria, chloroplasts, peroxisomes, the Golgi-complex and intracellular membrane systems. NO synthesis plays specific roles in these compartments and, in turn, cell organelles also control intracellular NO levels. This monograph focuses on the roles played by the subcellular NO-signaling microdomains in the prokaryote-, fungus-, plant- and animal cells and shows how NO behaves as an intracellular signal in distinct cellular environments. This monograph also provides a summary of our knowledge on how NO synthesis came through evolution to be associated with organelles and subcellular compartments. Promotes the novel ideas that some functions of NO and its associations with subcellular units have been conserved during the evolution of the cell. A special chapter is dedicated to the biomedical relevance of subcellular NO synthesis, and this chapter also discusses the evidence that altered compartmentalization of NO-producing enzymes causes disease.
  • Digital/Print
    edited by Marlene A. DeLuca, William D. McElroy.
    Digital : ScienceDirect1986
    Print1986
  • Digital/Print
    edited by Miriam M. Ziegler, Thomas O. Baldwin.
    Digital : ScienceDirect2000
    Print2000
  • Digital
    edited by Christian E. Badr.
    Springer Protocols2014
    Bioluminescence imaging : basics and practical limitations / Christian E. Badr -- Extraction and quantification of adenosine triphosphate in mammalian tissues and cells / Junji Chida and Hiroshi Kido -- Neuronal network imaging in acute slices using Ca2+ sensitive bioluminescent reporter / Ludovic Tricoire and Bertrand Lambolez -- Gaussia luciferase-based mycoplasma detection assay in mammalian cell culture / M. Hannah Degeling ... [et al.] -- Split gaussia luciferase for imaging ligand-receptor binding / Kathryn E. Luker and Gary D. Luker -- Video-rate bioluminescence imaging of protein secretion from a living cell / Takahiro Suzuki and Satoshi Inouye -- Bioluminescence reporter gene-based detection of microRNAs / Hae Young Ko, Young Sik Lee, and Soonhag Kim -- Monitoring of transcriptional dynamics of HIF and NFKB activities / Miguel A.S. Cavadas and Alex Cheong -- Real-time bioluminescent tracking of cellular population dynamics / Dan Close ... [et al.] -- Fabrication of bioluminescent capsules and live-cell imaging / Sung Bae Kim -- Bioluminescent imaging of spontaneously occurring tumors in immunocompetent ODD-luciferase bearing transgenic mice / Scott J. Goldman and Shengkan Jin -- Blood-based assay with secreted gaussia luciferase to monitor tumor metastasis / Hiroshi Yamashita, Dan T. Nguyen, and Euiheon Chung -- Bioluminescence imaging of fungal biofilm development in live animals / Greetje Vande Velde ... [et al.] -- Bioluminescent imaging of bacteria during mouse infection / Jonathan M. Warawa and Matthew B. Lawrenz -- Cell-based bioluminescence screening assays / Romain J. Amante and Christian E. Badr -- Bioluminescence-based monitoring of virus vector- mediated gene transfer in mice / Casey A. Maguire -- Simultaneous in vivo monitoring of regulatory and effector T lymphocytes using secreted gaussia luciferase, firefly luciferase, and secreted alkaline phosphatase / Grant K. Lewandrowski ... [et al.] -- Multiplex functional bioluminescent reporters using gaussia luciferase fused to epitope tags in an immunobinding assay / Sjoerd van Rijn, Thomas Würdinger, and Jonas Nilsson -- Noninvasive in vivo monitoring of extracellular vesicles / Charles P. Lai, Bakhos A. Tannous, and Xandra O. Breakefield -- In vitro and in vivo demonstrations of fluorescence by unbound excitation from luminescence (FUEL) / Joe Dragavon ... [et al.].
  • Digital
    edited by Feng Wang.
    Springer2008
  • Digital
    Christoph W. Turck, editor.
    Springer2008.
  • Digital
    edited by Sudhir Srivastava, PH. D, MPH.
    Wiley2017
    Nuts and bolts of biomarker research / Sharmistha Ghosh and Sudhir Srivastava -- Cancer genome methylation : biology, biomarker and therapeutic opportunities / Shashwat Sharad, Taduru Sreenath, Shiv Srivastava, and Albert Dobi -- Microrna biomarkers for early detection of cancer / Wendy Wang, Matthew R. Young, and Sudhir Srivastava -- Inflammation and cancer / Pamela L. Beatty, Sandra Cascio, and Olivera J Finn -- Exosomes : a valuable biomedical tool in biomarker discovery and development / Jocelyn Lee, Sharmistha Ghosh, and Sudhir Srivastava -- Epithelial-to-mesenchymal transition (EMT) : clinical implications / Elisa CWoodhouse and Suresh Mohla -- Breast cancer / Benjamin A. Katchman, Christos Patriotis, and Karen S Anderson -- Ovarian cancer / Christos Patriotis, Archana Simmons, Karen H. Lu, Robert C. Bast, Jr, and Steven J. Skates -- Esophageal cancer biomarkers / Yanxin Luo, Kishore Guda, Sanford Markowitz, Amitabh Chak, Andrew M Kaz, and William M Grady -- Predictive biomarkers for therapy in adenocarcinoma of the upper digestive tract / Heath D Skinner, Qiongrong Chen, Elena Elimova, Roopma Wadhwa, Shumei Song, and Jaffer A Ajani -- Pancreatic cancer / Sam CWang and Peter J Allen -- Colon cancer / Paul DWagner -- Prognosis and predictive biomarkers for colorectal cancer / Upender Manne, Balananda-Dhurjati Kumar Putcha, Temesgen Samuel, and Sudhir Srivastava -- Early detection of lung cancer / Mohamed Hassanein, Melinda C. Aldrich, Stephen A. Deppen, Karl E. Krueger, Eric L. Grogan, and Pierre P. Massion -- Commonalities in lung cancer and COPD / Malgorzata Wojtowicz and Eva Szabo -- Prostate cancer / Jacob Kagan, Ian M. Thompson, and Daniel W. Chan -- Improving the clinical validity of biomarker research in cancer detection / David F. Ransohoff -- Cancer overdiagnosis, ramifications and research strategies / Barbara K. Dunn and Barnett S. Kramer -- Predictive markers and driver genes from treatment trials : potential utility for early diagnosis / Brian S. Sorg, Sarfraz Memon, Kelly Y. Kim, Aniruddha Ganguly, Tracy Lively, James Tricoli, Magdalena Thurin, Lokesh Agrawal, Tawnya C. McKee, Barbara A. Conley, and J. Milburn Jessup -- Statistical consideration in predictive and prognostic markers / Fei Ye and Yu Shyr -- Clinical validation of molecular biomarkers in translational medicine / Harry B. Burke and William E. Grizzle -- Cancer biomarker assays : performance standards / Anna K Fuzery and Daniel W. Chan -- Bioethics and cancer biomarker research / Nathan Nobis, William Grizzle, and Stephen Sodeke -- Colon cancer screening / Molly Perencevich, Jennifer Inra, and Sapna Syngal.
  • Digital
    Uttam Garg, Laurie D. Smith.
    ScienceDirect2017
    1. Introduction to laboratory diagnosis and biomarkers in inborn error of metabolism -- 2. Amino acids disorders -- 3. Organic acid disorders -- 4. Disorders of mitochondrial fatty acid β-oxidation -- 5. Urea cycle and other disorders of hyperammonemia -- 6. Newborn screening -- 7. Carbohydrate disorders -- 8. Mitochondrial disorders -- 9. Lysosomal storage disorders: mucopolysaccharidoses -- 10. Lysosomal storage disorders: sphingolipidoses -- 11. Peroxisomal disorders: clinical and biochemical laboratory aspects -- 12. Disorders of purine and pyrimidine metabolism -- 13. Biomarkers for the study of catecholamine and serotonin genetic diseases -- 14. Cerebral creatine deficiency syndromes -- 15. Congenital disorders of glycosylation -- 16. Disorders of vitamins and cofactors -- 17. Disorders of trace metals -- Index.
  • Digital
    edited by Charles L. Edelstein.
    ScienceDirect2011
    Chapter 1. Characteristics of an Ideal Biomarker of Kidney Diseases / Michael R. Bennett, Prasad Devarajan -- Chapter 2. Statistical Considerations in Analysis and Interpretation of Biomarker Studies / Chirag R. Parikh, Heather Thiessen Philbrook -- Chapter 3. The Role of Metabolomics in the Study of Kidney Diseases and in the Development of Diagnostic Tools / Uwe Christians, Jeska Albuisson, Jost Klawitter, Jelena Klawitter -- Chapter 4. The Role of Proteomics in the Study of Kidney Diseases and in the Development of Diagnostic Tools / Uwe Christians, Stephanie McCrery, Jost Klawitter, Jelena Klawitter -- Chapter 5. Biomarkers in Acute Kidney Injury / Charles L. Edelstein, Sarah Faubel -- Chapter 6. Biomarkers in Kidney Transplantation / Alkesh Jani -- Chapter 7. Cystatin C as a Biomarker in Kidney Disease / Anders Grubb -- Chapter 8. Biomarkers of Renal Cancer / Naveen S. Vasudev, Rosamonde E. Banks -- Chapter 9. Urinary Proteomics and Candidate Biomarker Discovery for Diabetic Nephropathy / Michael L. Merchant, Jon B. Klein -- Chapter 10. Biomarkers in Glomerular Disease / John M. Arthur, Milos N. Budisavljevic, Michael G. Janech -- Chapter 11. Biomarkers in Preeclampsia / Ana Sofia Cerdeira, S. Ananth Karumanchi.
  • Digital
    Fausto Rodriguez, Cheng-Ying Ho.
    Springer2016
    Introduction -- Special Techniques -- Biobanking and Regulations -- Public Databases -- Biomarkers applied to specific tumor types -- Conclusions.
  • Digital
    Filipe Palavra, Flávio Reis, Daniela Marado, Armando Sena, editors.
    Springer2015
    Inflammation biomarkers and cardiometabolic risk -- Cardiovascular disease -- Diabetes mellitus and metabolic syndrome -- Ischemic stroke -- Chronic kidney disease -- Immune-mediated inflammatory rheumatic diseases -- Cardiometabolic risk, inflammation and neurodegenerative disorders.
  • Digital
    edited by Charles L. Edelstein.
    ClinicalKey2017
    Chapter 1: Characteristics of an Ideal Biomarker of Kidney Diseases / M.R Bennett aand P. Devarajan -- Chapter 2: Statistical Considerations in Analysis and Interpretation of Biomarker Studies / C.R. Parikh and H. Theissen Philbrook -- Chapter 3: The Role of Metabolomics in the Study of Kidney Diseases and in the Development of Diagnostic Tools / U. Christians, J. Klawitter, J. Klepacki and J. Klawitter -- Chapter 4: The Role of Proteomics in the Study of Kidney Diseases and in the Development of Diagnostic Tools / U. Christians, J. Klawitter, J. Klepacki and J. Klawitter -- Chapter 5: Cystatin C as a Multifaceted Biomarker in Kidney Disease and Its Role in Defining "Shrunken Pore Syndrome" / A. Grubb -- Chapter 6: Biomarkers in Acute Kidney Injury / C.L. Edelstein -- Chapter 7: Biomarkers of Extra-Renal Complications of AKI / S. Faubel -- Chapter 8: Biomarkers in Kidney Transplantation / S. Jain and A. Jani -- Chapter 9: Biomarkers of Renal Cancer / N.S. Vasudev and R.E. Banks -- Chapter 10: Proteomics and Advancements in Urinary Biomarkers of Diabetics Kidney Disease / M.L. Merchant and J.B. Klein -- Chapter 11: Biomarkers of Cardiovascular Risk in Chronic Kidney Disease / Z.H. Endre and R.J. Walker -- Chapter 12: Diagnostic and Prognostic Biomarkers in Autosomal Dominant Polycystic Kidney Disease / G. Fick-Brosnahan and B.Y. Reed -- Chapter 13: Biomarkers in Glomerular Disease / J.M. Arthur, E. Elnagar and N. Karakala -- Chapter 14: Biomarkers in Preeclampsia / S.A. Karamanchi.
  • Digital/Print
    edited by Willis A. Wood, Scott T. Kellogg.
    Digital : ScienceDirect1988
    Print1988
  • Digital
    edited by Michael E. Himmel.
    Springer Protocols2012
    Challenges for assessing the performance of biomass degrading biocatalysts / Michael E. Himmel, Stephen R. Decker, and David K. Johnson -- Overview of computer modeling of cellulose / Malin Bergensträhle-Wohlert and John W. Brady -- Imaging cellulose using atomic force microscopy / Shi-You Ding and Yu-San Liu -- Preservation and preparation of lignocellulosic biomass samples for multi-scale microscopy analysis / Bryon S. Donohoe, Peter N. Ciesielski, and Todd B. Vinzant -- Coherent raman microscopy analysis of plant cell walls / Yining Zeng, Michael E. Himmel, and Shi-You Ding -- Immunological approaches to plant cell wall and biomass characterization : glycome profiling / Sivakumar Pattathil [and others] -- Immunological approaches to plant cell wall and biomass characterization : immunolocalization of glycan epitopes / Utku Avci, Sivakumar Pattathil, and Michael G. Hahn -- Method to evaluate biomass accessibility in wet state based on thermoporometry / Bon-Wook Koo and Sunkyu Park -- Cellulase processivity / David B. Wilson and Maxim Kostylev -- Simple method for determining specificity of carbohydrate-binding modules for purified and crude insoluble polysaccharide substrates / Oren Yaniv [and others] -- Bacterial cadherin domains as carbohydrate binding modules : determination of affinity constants to insoluble complex polysaccharides / Milana Fraiber [and others] -- Affinity electrophoresis as a method for determining substrate-binding specificity of carbohydrate-active enzymes for soluble polysaccharides / Sarah Moraïs, Raphael Lamed, and Edward A. Bayer -- Single-molecule tracking of carbohydrate-binding modules on cellulose using fluorescence microscopy / Yu-San Liu, Shi-You Ding, and Michael E. Himmel -- Bioprospecting metagenomics for new glycoside hydrolases / Jack Gilbert [and others] -- Anaerobic high-throughput cultivation method for isolation of thermophiles using biomass-derived substrates / Scott D. Hamilton-Brehm [and others] -- Assessing the protein concentration in commercial enzyme preparations / William S. Adney [and others] -- Reducing the effect of variable starch levels in biomass recalcitrance screening / Stephen R. Decker [and others] -- Analysis of transgenic glycoside hydrolases expressed in plants : T. reesei CBH I and A. cellulolyticus EI / Roman Brunecky [and others] -- Structural characterization of the heteroxylans from poplar and switchgrass / Koushik Mazumder [and others] -- Laser microdissection and genetic manipulation technologies to probe lignin heterogeneity and configuration in plant cell walls / Oliver R.A. Corea [and others] -- Lignin-degrading enzyme activities / Yi-ru Chen, Simo Sarkanen, and Yun-Yan Wang.
  • Digital
    edited by Véronique Migonney.
    Wiley2014
    History of biomaterials / Véronique Migonney -- Definitions / Véronique Migonney -- Materials used in biomaterial applications / Géraldine Rohman -- Biocompatibility and norms / Véronique Migonney -- Bioactive polymers and surfaces: a solution for implant devices / Véronique Migonney -- Functionalization of biomaterials and applications / Céline Falentin-Daudre -- Biomaterial structures for anterior cruciate ligament replacement / Cédryck Vaquette -- Animal models for orthopedic applications of tissue engineering / Véronique Viateau, Adeline Decambron, Mathieu Manassero -- Ceramic materials for dental prostheses / Amélie Mainjot -- Dental adhesives / Mathieu Derbanne, Stéphane Le Goff, Jean-Pierre Attal -- Glass ionomer cements: application in pediatric dentistry / Elisabeth Dursun, Stéphane Le Goff, Jean-Pierre Attal -- List of authors.
  • Digital
    edited by Peter X. Ma, University of Michigan.
    Cambridge2014
    Knovel2014
    "Written by world-leading experts, this book focusses on the role of biomaterials in stem cell research and regenerative medicine. Emphasising basic principles and methodology, it covers stem cell interactions, fabrication technologies, design principles, physical characterisation and biological evaluation, across a broad variety of systems and biomaterials. Topics include: stem cell biology, including embryonic stem cells, IPS, HSC and progenitor cells; modern scaffold structures, including biopolymer, bioceramic, micro- and nanofiber, ECM and biohydrogel; advanced fabrication technologies, including computer-aided tissue engineering and organ printing; cutting-edge drug delivery systems and gene therapy techniques; medical applications spanning hard and soft tissues, the cardiovascular system and organ regeneration. With a contribution by Nobel laureate Shinya Yamanaka, this is a must-have reference for anyone in the field of biomaterials, stem cell biology and engineering, tissue engineering and regenerative medicine"--Provided by publisher.
  • Digital
    edited by Kinam Park.
    ScienceDirect2013
    Part I Fundamentals of biomaterials for cancer therapeutics; 1 Introduction to biomaterials for cancer therapeutics; 1.1 Introduction; 1.2 Biomaterials used in cancer therapeutics; 1.3 Materials used in anticancer formulations; 1.4 Conclusion and future trends; 1.5 References; 2 Cancer cell biology; 2.1 Introduction; 2.2 Public perception and misunderstanding of cancer cell activity; 2.3 The 'War on Cancer'; 2.4 The genetic basis of cancer; 2.5 Cancer interface with the environment; 2.6 Cancer cells as moving targets; 2.7 Conclusion and future trends; 2.8 References; 3 Targeted drug delivery for cancer therapy; 3.1 Introduction; 3.2 Current paradigm; 3.3 Challenges to current paradigm; 3.4 Conclusion and future trends; 3.5 References; Part II Synthetic vaccines, proteins, and polymers for cancer therapeutics; 4 Chemical synthesis of carbohydrate-based vaccines against cancers; 4.1 Introduction; 4.2 Semi-synthetic vaccines; 4.3 Fully synthetic vaccines; 4.4 Conclusion and future trends; 4.5 References; 5 Generating functional mutant proteins to create highly bioactive anticancer biopharmaceuticals; 5.1 Introduction; 5.2 Artificial proteins for cancer therapy; 5.3 How to create functional mutant proteins as beneficial therapeutics; 5.4 Mutant TNF(alpha) for cancer therapy; 5.5 Conclusion and future trends; 5.6 Sources of further information and advice; 5.7 References; 6 Polymer therapeutics for treating cancer; 6.1 Introduction; 6.2 Polyamines and polyamine analogs; 6.3 Polymeric P-glycoprotein (Pgp) inhibitors; 6.4 Conclusion and future trends; 6.5 Acknowledgment; 6.6 References; Part III Theranosis and drug delivery systems for cancer therapeutics; 7 Nanotechnology for cancer screening and diagnosis; 7.1 Introduction; 7.2 Nanotechnology for cancer diagnosis; 7.3 Nanotechnology-based biosensing platforms; 7.4 Nanotechnology for biosensing -- early detection of cancer; 7.5 Nanotechnology for cancer imaging; 7.6 Concerns with using nanomaterials; 7.7 Conclusion and future trends; 7.8 References; 8 Synergistically integrated nanomaterials for multimodal cancer cell imaging; 8.1 Introduction; 8.2 Nanomaterial-based multifunctional imaging probes; 8.3 Nanoparticles with exogenous imaging ligands; 8.4 Nanoparticles with endogenous contrast; 8.5 Cocktail injection; 8.6 Conclusion; 8.7 References; 9 Hybrid nanocrystal as a versatile platform for cancer theranostics; 9.1 Introduction; 9.2 Imaging modality; 9.3 Developing theranostic systems; 9.4 Hybrid nanocrystal as theranostic platform; 9.5 Conclusion; 9.6 Acknowledgment; 9.7 References; 10 Embolisation devices from biomedical polymers for intra-arterial occlusion and drug delivery in the treatment of cancer; 10.1 Introduction; 10.2 Biomedical polymers and embolisation agents; 10.3 Particulate embolisation agents; 10.4 Drug-eluting embolisation beads; 10.5 Polymer structure, form and property relationships; 10.6 Experience with drug-eluting embolisation beads; 10.7 Conclusions and future trends; 10.8 Acknowledgement; 10.9 References; 11 Small interfering RNAs (siRNAs) as cancer therapeutics; 11.1 Introduction; 11.2 Prerequisites for siRNAs cancer therapeutics; 11.3 Delivery systems of anticancer siRNAs; 11.4 Current challenges for clinical trials; 11.5 Conclusion; 11.6 Acknowledgement; 11.7 References; 12 Reverse engineering of the low temperature-sensitive liposome (LTSL) for treating cancer; 12.1 Introduction; 12.2 What is reverse engineering?; 12.3 Investigating the thermal-sensitive liposome's performance-in-service; 12.4 Defining the function of the liposome; 12.5 Component design: mechanism of action; 12.6 Selecting the most appropriate material when designing the Dox-LTSL; 12.7 Analysis of materials performance in the design; 12.8 Specification sheet; 12.9 Production; 12.10 Prototypes; 12.11 Further development; 12.12 Conclusion and future trends; 12.13 Acknowledgements; 12.14 References; 13 Gold nanoparticles (GNPs) as multifunctional materials for cancer treatment; 13.1 Introduction; 13.2 Physical properties of gold nanoparticles; 13.3 Surface chemistry of GNPs; 13.4 GNPs as vehicles for drug delivery; 13.5 GNPs in biomedical imaging and theranostics; 13.6 GNPs as radiosensitizing agents; 13.7 Challenges in the development of GNPs as therapeutic agents; 13.8 Conclusion and future trends; 13.9 Acknowledgments; 13.10 Bibliography; 14 Multifunctional nanosystems for cancer therapy; 14.1 Introduction; 14.2 Design of multifunctional nanosystems; 14.3 Illustrative examples of multifunctional nanosystems for tumor-targeted therapies; 14.4 Polymeric nanosystems; 14.5 Lipid nanosystems; 14.6 Hybrid nanosystems; 14.7 Regulatory and clinical perspectives; 14.8 Conclusions; 14.9 References; Part IV Biomaterial therapeutics and cancer cell interaction; 15 Biomaterial strategies to modulate cancer; 15.1 Introduction; 15.2 Understanding cancer with biomaterials; 15.3 Molecular markers for cancer; 15.4 Biomaterials for cancer therapy; 15.5 Conclusion; 15.6 References; 16 3D cancer tumor models for evaluating chemotherapeutic efficacy; 16.1 Introduction; 16.2 Efforts to fight cancer; 16.3 Preclinical drug evaluation in cellular and animal models; 16.4 In vivo environment; 16.5 2D vs 3D culture systems; 16.6 3D tumor models; 16.7 Methods to culture multicellular tumor spheroids; 16.8 Conclusion; 16.9 References; 17 Nanotopography of biomaterials for controlling cancer cell function; 17.1 Introduction;17.2 The influence of surface topography and roughness of PLGA on cancer cells: creation of nanoscale PLGA surfaces; 17.3 The influence of nanoscale PLGA topographies on surface wettability and surface free energy; 17.4 The influence of PLGA nanotopographies on protein adsorption; 17.5 The impact of PLGA surface nanopatterns on cancer cell functions; 17.6 The impact of nanopatterns and LBL monolayers on cell functions; 17.7 Conclusions; 17.8 References; Index.
  • Digital
    editors S. Rodil, A. Almaguer, K. Anselme, J. Castro.
    Cambridge2012
  • Digital
    volume editor, Sanjukta Deb.
    Karger2015
    Biomaterials in relation to dentistry / Deb, S. -- Polymer therapeutics in relation to dentistry / Rojo, L., Deb, S . -- Biological impact of bioactive glasses and their dissolution products / Hoppe, A., Boccaccini, A.R. -- Organic-inorganic composites toward biomaterial application / Miyazaki, T., Sugawara-Narutaki, A., Ohtsuki, C. -- New advanced materials for high performance at the resin-dentine interface / Toledano, M., Osorio, R. -- Nanobiomaterial coatings in dentistry / Choi, A.H., Cazalbou, S., Ben-Nissan, B. -- The effect of titanium surface modifications on dental implant osseointegration / Annunziata, M., Guida, L. -- Global gene expression analysis for the assessment of nanobiomaterials / Hanagata, N. -- Membranes for periodontal regeneration -- a material perspective / Bottino, M.C., Thomas, V. -- Biomaterials in the reconstruction of the oral and maxillofacial region / Ayoub, A., Al-Fotawei, R.
  • Digital
    Shuko Suzuki, Yoshito Ikada.
    Springer2012
    1. Introduction -- 2. Biological Events Associated with Surgical Operation -- 3. Bioabsorbable Polymers -- 4. Sealants (Adhesives) to Prevent Bleeding -- 5. Barriers to Prevent Tissue Adhesion -- 6. Devices for Bone Fixation -- 7. Growth Factors for Promoting Wound Healing -- 8. Sutures for Wound Closure -- 9. Conclusions.
  • Digital
    Antonio Merolli, Thomas J. Joyce, (eds.) ; foreword by Frédéric Schuind.
    Springer2009
  • Digital
    edited by Susmita Bose, Amit Bandyopadhyay, Roger Narayan.
    Wiley2013
    This volume is a collection of 15 research papers from the Next Generation Biomaterials and Surface Properties of Biomaterials symposia which took place during the Materials Science & Technology 2012 Conference & Exhibition (MS & T'12) in Pittsburgh, Pennsylvania.
  • Digital
    edited by Susmitya Bose, Amit Bandyopadhyay Roger Narayan.
    Wiley2014
    This volume is a collection of research papers from the Next Generation Biomaterials and Surface Properties of Biomaterials symposia which took place during the Materials Science & Technology 2013 Conference & Exhibition (MS&T'13) in Montréal, Quebec, Canada.
  • Digital
    KwonSoo Chun.
    While coronary heart diseases are considered the most deadly medical conditions in terms of overall deaths per year, orthopedic maladies are the costliest. One of the most prevalent orthopedic conditions is low back pain, which stems from degenerative tissue changes within the spinal column and associated spinal cord and peripheral nerve injuries. Treatment successes in conservative and surgical treatment are mixed, although the rates of spine surgery have dramatically increased over the past decade. Surgical treatment is considered a last resort, and of all the surgical approaches, spinal fusion is the most common for the treatment of low back pain. Since spinal fusion has been in use in the clinic for several decades now, results of long-term retrospective clinical reviews are now becoming available. Some of these studies have shown that spinal fusion may induce secondary injuries such as adjacent tissue regeneration, which may require additional surgical treatment. To overcome some of these complications, posterior dynamic stabilization has been introduced as an alternative to fusion surgery. Posterior dynamic stabilization is still considered mostly experimental and the majority of spine companies with ambitions in this field have not yet settled on particular design goals and implant concepts. A significant hurdle for entry to the market for such devices is the lack of understanding of what the ideal function of the device is, and how the implants should interact with the spinal column. The objective of this thesis was to evaluate the functionality of posterior dynamic stabilization depending on patient conditions such as mobility and body mass and to suggest efficient rigidities of the dynamic device when considering patients' characteristics. This study is divided into three specific aims. The purpose of the first aim was to investigate the significant influence of a patient's spinal kinematics on dynamic stabilization. The patients were divided by segmental range of motion (L3-L4) into two groups (hyper-mobility and hypo-mobility) and finite element (FE) models were generated for these respective groups. This study showed that patient characteristics such as mobility produced different spinal kinematics after dynamic stabilization and demonstrated that the effectiveness of dynamic stabilization was increased when the mechanical properties of the device were changed in response to patient characteristics. The purpose of the second aim was to evaluate the stabilization devices in relation to patients' body mass and spinal mobility, testing the effects of dynamic stabilization devices of varying levels of rigidity. Based on analyzed results of the spinal mobility at the diseased level (L4-L5), the hyper-mobility patients were divided into three groups, based on severity. Depending on the body mass in the hyper-mobility patients, the patients were divided into three groups. The findings of the study demonstrated the significant influence of patients' body mass and mobility on spinal kinematics after dynamic stabilization. The purpose of the third aim was to investigate the effect of implant rigidity on spinal kinematics utilizing a cadaveric tissue model. This in-vitro study was designed to validate the biomechanical influence of physiological loading after dynamic stabilization. The results of this in-vitro study showed that patients' characteristics change spinal segmental motion and different implant rigidities of the dynamic stabilization device also produce varying spinal kinematics depending on patients' conditions. Through these in-vitro tests, this thesis readdresses the importance of considering patient characteristics in the design of appropriate devices for spinal stabilization, and to select the right implants for the right patient population.
  • Digital
    Elizabeth Choe Yu.
    Cardiomyopathies are diseases of the myocardium resulting in heart failure, arrhythmia, and sudden death. Cardiomyopathies represent a major cause of morbidity and mortality in all age groups and recent application of human genomic technologies has revealed thousands of gene mutations that cause inherited and sporadic cardiomyopathies. Many mutations in the beta-cardiac myosin heavy chain (beta-MHC) gene, which encodes the motor that powers ventricular contraction, have been identified to cause inherited cardiomyopathies, including dilated cardiomyopathy (DCM). However, the molecular mechanisms by which these mutations alter the force generation and kinetic properties of the myosin molecule have not been elucidated. As a result, there are no available therapies targeted toward treating the underlying cause of these diseases to date. We have successfully adapted a system to produce recombinant human cardiac myosin motor domain, known as subfragment-1 (S1), using a mammalian myoblast cell line. This technique has allowed us to obtain significant quantities of highly purified recombinant human beta-cardiac myosin S1 for in-depth functional analyses of wild type and DCM-causing mutants. Characterization of biomechanical properties of DCM causing human beta-cardiac S1 demonstrated that DCM mutations results in an overall hypo-contractile state, although the fundamental mechanistic changes that lead to decreased power output vary. In the future, more complex systems can be analyzed by performing assays with regulated thin filaments instead of actin and double-headed myosin motors to gain further insights into the effects of beta-MHC mutations on cardiac myosin function. Furthermore, using emerging induced pluripotent stem cell (iPSC) technology, insights into the effects of these mutations of myosin biomechanical function in vitro can be correlated with their effects on cardiomyocyte function at the cellular level. Further understanding of these mechanisms can guide the search for specific therapeutic targets and lead to the development of small molecules to modulate the effects of the DCM-causing mutations and potentially prevent or reverse this clinically devastating disease.
  • Digital
    Jennifer Lee Hicks.
    Many children with cerebral palsy walk with excessive knee flexion, an inefficient locomotion pattern known as crouch gait that progressively worsens over time without intervention. Patients often receive surgeries to lengthen tight or spastic muscles or to correct bone malalignments, but outcomes are variable and unpredictable. The goals of this dissertation were, first, to objectively identify biomechanical factors that cause a patient to walk with excess knee flexion and, second, to use these factors to predict whether a patient's crouch gait will improve after receiving treatment. We first determined the influence of abnormal bone geometry and crouched gait postures on the function of muscles during walking using a three-dimensional model of the musculoskeletal system. Our analysis revealed that a tibial torsion deformity, a common bone malalignment, reduces the capacity of lower limb muscles to generate extension of the knee and hip joints. Excess tibial torsion may thus be a significant contributor to crouch gait and warrant surgical correction. In addition, our analysis showed that a crouched gait posture markedly reduces the capacity of most lower limb muscles to extend the knee and hip joints. These findings help explain the altered muscle activations, increased energy requirements, and increased joint loading associated with walking in a crouch gait. We also developed a multi-variable linear regression model to estimate how much subjects' crouch gait would change between hospital visits by retrospectively analyzing patients' gait kinematics over time and surgical histories. The regression model was able to explain 49% of the variance in the change in knee flexion between gait visits for the 353 subject-limbs that we analyzed. Further, the regression model classified subject-limbs as 'Improved' or 'Unimproved' with approximately 70% accuracy, which contrasts with the observed improvement rate of 48% among subject-limbs in the study. We further demonstrated that more improvement in crouch gait was expected when subjects had i) adequate hamstrings lengths and velocities, ii) normal tibial torsion, and iii) greater extensor muscle strength, three variables drawn from our knowledge about the biomechanics of crouch gait. This work establishes a new framework--combining biomechanical modeling and statistical analysis--for understanding gait pathology and objectively planning treatment.
  • Digital
    Ghias Kharmanda, Abdelkhalak El Hami.
    Wiley2017
  • Digital
    Dominique G. Poitout, editor.
    Springer2016
    I. Introduction -- II. Biocompatible Materials -- III. Tissue Biomechanics and Histomorphology -- IV. Biomechanics of Bone Growth -- V. Applications of Biomechanical Principles to Orthopedics and Traumatology -- VI. Applications of Biomechanics Principles to Oncology -- VII. Articular Biomechanics.
  • Print
    editor, Hiroshi Wada.
  • Digital
    Mark R. Pitkin.
    Springer2011
    Floating Skeleton Concept -- Sanomechanics -- Biomechanics for Life -- SanomechanicsTM Exercises -- About Forces and Moments in Locomotion -- Sanomechanics for Respiration.
  • Digital
    Jennifer Tryggvi Blundo.
    This dissertation investigated the role of biomechanics in two physiological systems, the heart and bone. Biomechanics motivates the study and characterization of how cells sense external forces and convert these signals into an intracellular response in a process called mechanotransduction. Three independent studies were designed with the goal of applying mechanical forces that mimic the in vivo microenvironment of either the heart or bone. The aim of these studies was to better under the mechanisms driving cellular processes, including cardiac myocyte differentiation and osteoblast mechanotransduction. The first study presents the design and implementation of tissue engineering approach to stem cell-based myocardial therapy. Three dimensional engineered heart tissue was formed by suspending human embryonic stem cell-derived cardiac myocytes isolated from beating embryoid bodies in a soluble extracellular matrix, and an in vitro mechanical conditioning regimen was applied at physiological levels of myocardial strain. The viability of the engineered stem cell tissue was monitored in vitro and in vivo for up to 8 weeks using molecular imaging of reporter gene activity. The application of cyclic mechanical strain in vitro resulted in cellular alignment along the axis of strain and an elongated cellular morphology with a high nuclear to cytoplasmic ratio, typical of neonatal cardiac myocytes, as well as increased expression of cardiac troponin I, in comparison to static controls. Analysis of the in vitro and in vivo bioluminescence imaging data demonstrated the viability of engineered heart tissue constructs; however, histology results showed immature cells within the implanted constructs, suggesting an inability of the stem cell-derived cardiac precursors to maintain a cardiac phenotype in vivo, as well the inherent inefficiency of the beating embryoid body method to identify and isolate cardiac myocyte precursors. The functional shortcomings exhibited by the embryoid body-based differentiation of embryonic stem cell-derived cardiac myocytes in the first study motivated further refinement of cardiac myocyte differentiation techniques. Therefore, the second study executed the design and fabrication of a microelectromechanical platform to study the role of electrical and mechanical stimulation in cardiac myocyte differentiation. The fabrication process used a combination of soft lithography and traditional microfabrication techniques to pattern thin film metal electrodes on an elastomeric polymer membrane. The completed device enabled coupled characterization and imaging of cardiac myocytes precursors, and the ability to assess the range of mechanical forces, up to 10% equibiaxial strain, that may induce or maintain a cardiac fate. Electrical continuity was demonstrated under static conditions but not under strain, and improvements in metal deposition and adhesion could address this performance defect. Beating clusters containing human embryonic stem cell-derived cardiac myocytes were plated on fabricated membranes, uncoated and coated with Matrigel, and cell viability was monitored using contrast microscopy. The third study transitioned to a different mechanical model of physiological forces, which was the application of oscillatory fluid flow-mediated fluid shear stress generated by the loading and unloading of bone. Specifically, the role of focal adhesion kinase, a protein tyrosine kinase recruited at focal adhesions and a major mediator of integrin signaling pathways, was studied in osteoblast mechanotransduction. The biochemical and transcriptional response of focal adhesion kinase mutant osteoblasts to physiological levels of shear stress induced by oscillatory fluid flow was impaired as measured by prostaglandin E2 release and cyclooxygenase-2 gene expression. Restoration of focal adhesion kinase expression with site-specific mutations at two tyrosine phosphorylation sites demonstrated that phosphorylation events play a role in prostaglandin release following oscillatory fluid flow. In conclusion, the role of mechanical forces, including the effect of cyclic mechanical strain in human embryonic stem cell-derived cardiac myocyte tissue engineering and the fluid shear stress-induced response of focal adhesion kinase mutant osteoblasts, was successfully demonstrated and quantified in this dissertation.

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